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1. Design of a Planar Sensor Based on Split-Ring Resonators for Non-Invasive Permittivity Measurement

Author

Mohammad Alibakhshikenari, Bal S. Virdee, Taha A. Elwi, Innocent D. Lubangakene, Renu K. R. Jayanthi, Amer Abbood Al-Behadili, Zaid A. Abdul Hassain, Syed Mansoor Ali, Giovanni Pau, Patrizia Livreri, and Sonia Aïssa

Subjects
split-ring resonator, sensor, complex permittivity, microstrip technology, Chemical technology, TP1-1185
Abstract

The permittivity of a material is an important parameter to characterize the degree of polarization of a material and identify components and impurities. This paper presents a non-invasive measurement technique to characterize materials in terms of their permittivity based on a modified metamaterial unit-cell sensor. The sensor consists of a complementary split-ring resonator (C-SRR), but its fringe electric field is contained with a conductive shield to intensify the normal component of the electric field. It is shown that by tightly electromagnetically coupling opposite sides of the unit-cell sensor to the input/output microstrip feedlines, two distinct resonant modes are excited. Perturbation of the fundamental mode is exploited here for determining the permittivity of materials. The sensitivity of the modified metamaterial unit-cell sensor is enhanced four-fold by using it to construct a tri-composite split-ring resonator (TC-SRR). The measured results confirm that the proposed technique provides an accurate and inexpensive solution to determine the permittivity of materials.

Published
2023
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2. Cooperation of loss of NKX3.1 and inflammation in prostate cancer initiation

Author

Clémentine Le Magnen, Renu K. Virk, Aditya Dutta, Jaime Yeji Kim, Sukanya Panja, Zoila A. Lopez-Bujanda, Andrea Califano, Charles G. Drake, Antonina Mitrofanova, and Cory Abate-Shen

Subjects
Prostate cancer, Cancer initiation, NKX3.1, Inflammation, Differentiation, Medicine, Pathology, RB1-214
Abstract

Although it is known that inflammation plays a critical role in prostate tumorigenesis, the underlying processes are not well understood. Based on analysis of genetically engineered mouse models combined with correlative analysis of expression profiling data from human prostate tumors, we demonstrate a reciprocal relationship between inflammation and the status of the NKX3.1 homeobox gene associated with prostate cancer initiation. We find that cancer initiation in aged Nkx3.1 mutant mice correlates with enrichment of specific immune populations and increased expression of immunoregulatory genes. Furthermore, expression of these immunoregulatory genes is similarly increased in human prostate tumors having low levels of NKX3.1 expression. We further show that induction of prostatitis in Nkx3.1 mutant mice accelerates prostate cancer initiation, which is coincident with aberrant cellular plasticity and differentiation. Correspondingly, human prostate tumors having low levels of NKX3.1 have de-regulated expression of genes associated with these cellular processes. We propose that loss of function of NKX3.1 accelerates inflammation-driven prostate cancer initiation potentially via aberrant cellular plasticity and impairment of cellular differentiation. This article has an associated First Person interview with the first author of the paper.

Published
2018
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3. Measures of Adiposity and Cardiovascular Disease Risk Factors, New York City Health and Nutrition Examination Survey, 2004

Author

R. Charon Gwynn, PhD, Magdalena Berger, MPH, Renu K. Garg, MPH, Elizabeth Needham Waddell, PhD, Robyn Philburn, MPH, and Lorna E. Thorpe, PhD

Subjects
adiposity and cardiovascular disease, heart disease, New York City Health and Nutrition Examination Survey, cardiovascular disease risk factors, Public aspects of medicine, RA1-1270
Abstract

IntroductionBody mass index (BMI) and indicators of central adiposity have been associated with cardiovascular disease (CVD) risk factors, but ambiguity remains about which measure optimally predicts CVD risk and is best suited for different racial/ethnic groups. We sought to characterize excess adiposity among New York City adults and assess the potential associations between multiple adiposity indicators and CVD risk factors, by race/ethnicity.MethodsThe New York City Health and Nutrition Examination Survey (NYC HANES) is a population-based survey of noninstitutionalized New York City adult residents aged 20 years or older. We compared the prevalence of obesity (BMI ≥30 kg/m2), elevated waist circumference (>102 cm for men, >88 cm for women), and elevated waist-to-height ratio (≥0.5) for participants in the 2004 NYC HANES (n = 1,912) and the 2003-2004 National Health and Nutrition Examination Survey (n = 4,075). Logistic regression was used to assess potential associations between each of these indicators of excess adiposity and CVD risk factors (diabetes, impaired fasting glucose, hypertension, and hypercholesterolemia), overall and by race/ethnicity.ResultsThe prevalence of obesity among NYC HANES participants was 26% and of elevated waist circumference was 46%, both significantly lower than national estimates (31% and 52%, respectively), whereas the prevalence of elevated waist-to-height ratio was higher (82% vs 79%). Most measures of excess adiposity were significantly associated with all CVD risk factors. No single measure of excess adiposity emerged as most consistently predictive of CVD risk in the general population or by race/ethnicity.ConclusionNew York City has a lower prevalence of obesity and elevated waist circumference but a higher prevalence of elevated waist-to-height ratio than found nationally. Further investigation into the optimal adiposity measure to predict CVD risk across racial/ethnic populations may be warranted.

Published
2011

8. Improvement in Performance of Ternary Sequence Using Binary Step Size LMS Algorithm

Author

Renu, K., Rajesh Kumar, P., Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Ruediger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Panda, Ganapati, editor, Satapathy, Suresh Chandra, editor, Biswal, Birendra, editor, and Bansal, Ramesh, editor

Published
2019
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11. A MYC and RAS co-activation signature in localized prostate cancer drives bone metastasis and castration resistance

Author

Arriaga, Juan M., Panja, Sukanya, Alshalalfa, Mohammed, Zhao, Junfei, Zou, Min, Giacobbe, Arianna, Madubata, Chioma J., Kim, Jaime Yeji, Rodriguez, Antonio, Coleman, Ilsa, Virk, Renu K., Hibshoosh, Hanina, Ertunc, Onur, Ozbek, Büşra, Fountain, Julia, Jeffrey Karnes, R., Luo, Jun, Antonarakis, Emmanuel S., Nelson, Peter S., Feng, Felix Y., Rubin, Mark A., De Marzo, Angelo M., Rabadan, Raul, Sims, Peter A., Mitrofanova, Antonina, and Abate-Shen, Cory

Published
2020
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12. Performance of Ternary Sequences Using Adaptive Filter

Author

Renu, K., Kumar, P. Rajesh, Angrisani, Leopoldo, Series editor, Arteaga, Marco, Series editor, Chakraborty, Samarjit, Series editor, Chen, Jiming, Series editor, Chen, Tan Kay, Series editor, Dillmann, Ruediger, Series editor, Duan, Haibin, Series editor, Ferrari, Gianluigi, Series editor, Ferre, Manuel, Series editor, Hirche, Sandra, Series editor, Jabbari, Faryar, Series editor, Kacprzyk, Janusz, Series editor, Khamis, Alaa, Series editor, Kroeger, Torsten, Series editor, Ming, Tan Cher, Series editor, Minker, Wolfgang, Series editor, Misra, Pradeep, Series editor, Möller, Sebastian, Series editor, Mukhopadhyay, Subhas Chandra, Series editor, Ning, Cun-Zheng, Series editor, Nishida, Toyoaki, Series editor, Panigrahi, Bijaya Ketan, Series editor, Pascucci, Federica, Series editor, Samad, Tariq, Series editor, Seng, Gan Woon, Series editor, Veiga, Germano, Series editor, Wu, Haitao, Series editor, Zhang, Junjie James, Series editor, Anguera, Jaume, editor, Satapathy, Suresh Chandra, editor, Bhateja, Vikrant, editor, and Sunitha, K.V.N., editor

Published
2018
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14. Metformin Overcomes the Consequences of NKX3.1 Loss to Suppress Prostate Cancer Progression

Author

Papachristodoulou, Alexandros, primary, Heidegger, Isabel, additional, Virk, Renu K., additional, Di Bernardo, Matteo, additional, Kim, Jaime Y., additional, Laplaca, Caroline, additional, Picech, Florencia, additional, Schäfer, Georg, additional, De Castro, Guarionex Joel, additional, Hibshoosh, Hanina, additional, Loda, Massimo, additional, Klocker, Helmut, additional, Rubin, Mark A., additional, Zheng, Tian, additional, Benson, Mitchell C., additional, McKiernan, James M., additional, Dutta, Aditya, additional, and Abate-Shen, Cory, additional

Published
2023
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15. Comparative safety of conjugated estrogens/bazedoxifene versus estrogen/progestin combination hormone therapy among women in the United States: a multidatabase cohort study

Author

Hoffman, Sarah R., primary, Governor, Samuel, additional, Daniels, Kimberly, additional, Seals, Ryan M., additional, Ziyadeh, Najat J., additional, Wang, Florence T., additional, Dai, Dingwei, additional, Mcmahill-Walraven, Cheryl N., additional, Shuminski, Patty, additional, Frajzyngier, Vera, additional, Zhou, Xiaofeng, additional, Shen, Rongjun, additional, Garg, Renu K., additional, Fournakis, Nicole, additional, Lanes, Stephan, additional, and Beachler, Daniel C., additional

Published
2023
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17. Design of a Planar Sensor Based on Split-Ring Resonators for Non-Invasive Permittivity Measurement

Author

Alibakhshikenari, Mohammad, primary, Virdee, Bal S., additional, Elwi, Taha A., additional, Lubangakene, Innocent D., additional, Jayanthi, Renu K. R., additional, Al-Behadili, Amer Abbood, additional, Hassain, Zaid A. Abdul, additional, Ali, Syed Mansoor, additional, Pau, Giovanni, additional, Livreri, Patrizia, additional, and Aïssa, Sonia, additional

Published
2023
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18. Supplementary Tables from NKX3.1 Localization to Mitochondria Suppresses Prostate Cancer Initiation

Author

Papachristodoulou, Alexandros, primary, Rodriguez-Calero, Antonio, primary, Panja, Sukanya, primary, Margolskee, Elizabeth, primary, Virk, Renu K., primary, Milner, Teresa A., primary, Martina, Luis Pina, primary, Kim, Jaime Y., primary, Di Bernardo, Matteo, primary, Williams, Alanna B., primary, Maliza, Elvis A., primary, Caputo, Joseph M., primary, Haas, Christopher, primary, Wang, Vinson, primary, De Castro, Guarionex Joel, primary, Wenske, Sven, primary, Hibshoosh, Hanina, primary, McKiernan, James M., primary, Shen, Michael M., primary, Rubin, Mark A., primary, Mitrofanova, Antonina, primary, Dutta, Aditya, primary, and Abate-Shen, Cory, primary

Published
2023
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19. Data from NKX3.1 Localization to Mitochondria Suppresses Prostate Cancer Initiation

Author

Papachristodoulou, Alexandros, primary, Rodriguez-Calero, Antonio, primary, Panja, Sukanya, primary, Margolskee, Elizabeth, primary, Virk, Renu K., primary, Milner, Teresa A., primary, Martina, Luis Pina, primary, Kim, Jaime Y., primary, Di Bernardo, Matteo, primary, Williams, Alanna B., primary, Maliza, Elvis A., primary, Caputo, Joseph M., primary, Haas, Christopher, primary, Wang, Vinson, primary, De Castro, Guarionex Joel, primary, Wenske, Sven, primary, Hibshoosh, Hanina, primary, McKiernan, James M., primary, Shen, Michael M., primary, Rubin, Mark A., primary, Mitrofanova, Antonina, primary, Dutta, Aditya, primary, and Abate-Shen, Cory, primary

Published
2023
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20. Supplementary Datasets from NKX3.1 Localization to Mitochondria Suppresses Prostate Cancer Initiation

Author

Papachristodoulou, Alexandros, primary, Rodriguez-Calero, Antonio, primary, Panja, Sukanya, primary, Margolskee, Elizabeth, primary, Virk, Renu K., primary, Milner, Teresa A., primary, Martina, Luis Pina, primary, Kim, Jaime Y., primary, Di Bernardo, Matteo, primary, Williams, Alanna B., primary, Maliza, Elvis A., primary, Caputo, Joseph M., primary, Haas, Christopher, primary, Wang, Vinson, primary, De Castro, Guarionex Joel, primary, Wenske, Sven, primary, Hibshoosh, Hanina, primary, McKiernan, James M., primary, Shen, Michael M., primary, Rubin, Mark A., primary, Mitrofanova, Antonina, primary, Dutta, Aditya, primary, and Abate-Shen, Cory, primary

Published
2023
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21. Supplementary Materials and Methods from NKX3.1 Localization to Mitochondria Suppresses Prostate Cancer Initiation

Author

Papachristodoulou, Alexandros, primary, Rodriguez-Calero, Antonio, primary, Panja, Sukanya, primary, Margolskee, Elizabeth, primary, Virk, Renu K., primary, Milner, Teresa A., primary, Martina, Luis Pina, primary, Kim, Jaime Y., primary, Di Bernardo, Matteo, primary, Williams, Alanna B., primary, Maliza, Elvis A., primary, Caputo, Joseph M., primary, Haas, Christopher, primary, Wang, Vinson, primary, De Castro, Guarionex Joel, primary, Wenske, Sven, primary, Hibshoosh, Hanina, primary, McKiernan, James M., primary, Shen, Michael M., primary, Rubin, Mark A., primary, Mitrofanova, Antonina, primary, Dutta, Aditya, primary, and Abate-Shen, Cory, primary

Published
2023
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22. Supplementary Data Index from NKX3.1 Localization to Mitochondria Suppresses Prostate Cancer Initiation

Author

Papachristodoulou, Alexandros, primary, Rodriguez-Calero, Antonio, primary, Panja, Sukanya, primary, Margolskee, Elizabeth, primary, Virk, Renu K., primary, Milner, Teresa A., primary, Martina, Luis Pina, primary, Kim, Jaime Y., primary, Di Bernardo, Matteo, primary, Williams, Alanna B., primary, Maliza, Elvis A., primary, Caputo, Joseph M., primary, Haas, Christopher, primary, Wang, Vinson, primary, De Castro, Guarionex Joel, primary, Wenske, Sven, primary, Hibshoosh, Hanina, primary, McKiernan, James M., primary, Shen, Michael M., primary, Rubin, Mark A., primary, Mitrofanova, Antonina, primary, Dutta, Aditya, primary, and Abate-Shen, Cory, primary

Published
2023
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23. Supplementary Figures from NKX3.1 Localization to Mitochondria Suppresses Prostate Cancer Initiation

Author

Papachristodoulou, Alexandros, primary, Rodriguez-Calero, Antonio, primary, Panja, Sukanya, primary, Margolskee, Elizabeth, primary, Virk, Renu K., primary, Milner, Teresa A., primary, Martina, Luis Pina, primary, Kim, Jaime Y., primary, Di Bernardo, Matteo, primary, Williams, Alanna B., primary, Maliza, Elvis A., primary, Caputo, Joseph M., primary, Haas, Christopher, primary, Wang, Vinson, primary, De Castro, Guarionex Joel, primary, Wenske, Sven, primary, Hibshoosh, Hanina, primary, McKiernan, James M., primary, Shen, Michael M., primary, Rubin, Mark A., primary, Mitrofanova, Antonina, primary, Dutta, Aditya, primary, and Abate-Shen, Cory, primary

Published
2023
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25. Design of a Planar Sensor Based on Split-Ring Resonators for Non-Invasive Permittivity Measurement

Author

Aïssa, Mohammad Alibakhshikenari, Bal S. Virdee, Taha A. Elwi, Innocent D. Lubangakene, Renu K. R. Jayanthi, Amer Abbood Al-Behadili, Zaid A. Abdul Hassain, Syed Mansoor Ali, Giovanni Pau, Patrizia Livreri, and Sonia

Subjects
split-ring resonator, sensor, complex permittivity, microstrip technology
Abstract

The permittivity of a material is an important parameter to characterize the degree of polarization of a material and identify components and impurities. This paper presents a non-invasive measurement technique to characterize materials in terms of their permittivity based on a modified metamaterial unit-cell sensor. The sensor consists of a complementary split-ring resonator (C-SRR), but its fringe electric field is contained with a conductive shield to intensify the normal component of the electric field. It is shown that by tightly electromagnetically coupling opposite sides of the unit-cell sensor to the input/output microstrip feedlines, two distinct resonant modes are excited. Perturbation of the fundamental mode is exploited here for determining the permittivity of materials. The sensitivity of the modified metamaterial unit-cell sensor is enhanced four-fold by using it to construct a tri-composite split-ring resonator (TC-SRR). The measured results confirm that the proposed technique provides an accurate and inexpensive solution to determine the permittivity of materials.

Published
2023
Full Text
View/download PDF

26. Supplementary Data Index from NKX3.1 Localization to Mitochondria Suppresses Prostate Cancer Initiation

Author

Cory Abate-Shen, Aditya Dutta, Antonina Mitrofanova, Mark A. Rubin, Michael M. Shen, James M. McKiernan, Hanina Hibshoosh, Sven Wenske, Guarionex Joel De Castro, Vinson Wang, Christopher Haas, Joseph M. Caputo, Elvis A. Maliza, Alanna B. Williams, Matteo Di Bernardo, Jaime Y. Kim, Luis Pina Martina, Teresa A. Milner, Renu K. Virk, Elizabeth Margolskee, Sukanya Panja, Antonio Rodriguez-Calero, and Alexandros Papachristodoulou

Abstract

List of all supplementary items included with the manuscript.

Published
2023
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27. Supplementary Materials and Methods from NKX3.1 Localization to Mitochondria Suppresses Prostate Cancer Initiation

Author

Cory Abate-Shen, Aditya Dutta, Antonina Mitrofanova, Mark A. Rubin, Michael M. Shen, James M. McKiernan, Hanina Hibshoosh, Sven Wenske, Guarionex Joel De Castro, Vinson Wang, Christopher Haas, Joseph M. Caputo, Elvis A. Maliza, Alanna B. Williams, Matteo Di Bernardo, Jaime Y. Kim, Luis Pina Martina, Teresa A. Milner, Renu K. Virk, Elizabeth Margolskee, Sukanya Panja, Antonio Rodriguez-Calero, and Alexandros Papachristodoulou

Abstract

Detailed materials and methods including references.

Published
2023
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28. Supplementary Figures from NKX3.1 Localization to Mitochondria Suppresses Prostate Cancer Initiation

Author

Cory Abate-Shen, Aditya Dutta, Antonina Mitrofanova, Mark A. Rubin, Michael M. Shen, James M. McKiernan, Hanina Hibshoosh, Sven Wenske, Guarionex Joel De Castro, Vinson Wang, Christopher Haas, Joseph M. Caputo, Elvis A. Maliza, Alanna B. Williams, Matteo Di Bernardo, Jaime Y. Kim, Luis Pina Martina, Teresa A. Milner, Renu K. Virk, Elizabeth Margolskee, Sukanya Panja, Antonio Rodriguez-Calero, and Alexandros Papachristodoulou

Abstract

Supplementary Figures and Figure legends

Published
2023
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29. Supplementary Datasets from NKX3.1 Localization to Mitochondria Suppresses Prostate Cancer Initiation

Author

Cory Abate-Shen, Aditya Dutta, Antonina Mitrofanova, Mark A. Rubin, Michael M. Shen, James M. McKiernan, Hanina Hibshoosh, Sven Wenske, Guarionex Joel De Castro, Vinson Wang, Christopher Haas, Joseph M. Caputo, Elvis A. Maliza, Alanna B. Williams, Matteo Di Bernardo, Jaime Y. Kim, Luis Pina Martina, Teresa A. Milner, Renu K. Virk, Elizabeth Margolskee, Sukanya Panja, Antonio Rodriguez-Calero, and Alexandros Papachristodoulou

Abstract

Datasets reported in the manuscript including gene expression, pathway analyses, and mass spectrometry data.

Published
2023
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30. Supplementary Tables from NKX3.1 Localization to Mitochondria Suppresses Prostate Cancer Initiation

Author

Cory Abate-Shen, Aditya Dutta, Antonina Mitrofanova, Mark A. Rubin, Michael M. Shen, James M. McKiernan, Hanina Hibshoosh, Sven Wenske, Guarionex Joel De Castro, Vinson Wang, Christopher Haas, Joseph M. Caputo, Elvis A. Maliza, Alanna B. Williams, Matteo Di Bernardo, Jaime Y. Kim, Luis Pina Martina, Teresa A. Milner, Renu K. Virk, Elizabeth Margolskee, Sukanya Panja, Antonio Rodriguez-Calero, and Alexandros Papachristodoulou

Abstract

This files contains all of the supplementary tables included in the manuscript.

Published
2023
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31. Data from NKX3.1 Localization to Mitochondria Suppresses Prostate Cancer Initiation

Author

Cory Abate-Shen, Aditya Dutta, Antonina Mitrofanova, Mark A. Rubin, Michael M. Shen, James M. McKiernan, Hanina Hibshoosh, Sven Wenske, Guarionex Joel De Castro, Vinson Wang, Christopher Haas, Joseph M. Caputo, Elvis A. Maliza, Alanna B. Williams, Matteo Di Bernardo, Jaime Y. Kim, Luis Pina Martina, Teresa A. Milner, Renu K. Virk, Elizabeth Margolskee, Sukanya Panja, Antonio Rodriguez-Calero, and Alexandros Papachristodoulou

Abstract

Mitochondria provide the first line of defense against the tumor-promoting effects of oxidative stress. Here we show that the prostate-specific homeoprotein NKX3.1 suppresses prostate cancer initiation by protecting mitochondria from oxidative stress. Integrating analyses of genetically engineered mouse models, human prostate cancer cells, and human prostate cancer organotypic cultures, we find that, in response to oxidative stress, NKX3.1 is imported to mitochondria via the chaperone protein HSPA9, where it regulates transcription of mitochondrial-encoded electron transport chain (ETC) genes, thereby restoring oxidative phosphorylation and preventing cancer initiation. Germline polymorphisms of NKX3.1 associated with increased cancer risk fail to protect from oxidative stress or suppress tumorigenicity. Low expression levels of NKX3.1 combined with low expression of mitochondrial ETC genes are associated with adverse clinical outcome, whereas high levels of mitochondrial NKX3.1 protein are associated with favorable outcome. This work reveals an extranuclear role for NKX3.1 in suppression of prostate cancer by protecting mitochondrial function.Significance:Our findings uncover a nonnuclear function for NKX3.1 that is a key mechanism for suppression of prostate cancer. Analyses of the expression levels and subcellular localization of NKX3.1 in patients at risk of cancer progression may improve risk assessment in a precision prevention paradigm, particularly for men undergoing active surveillance.See related commentary by Finch and Baena, p. 2132.This article is highlighted in the In This Issue feature, p. 2113

Published
2023
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34. Current perspectives on neuroendocrine tumors

Author

Sunil Kumar Verma, Renu Khare, and Devendra Singh

Subjects
cancer, clinical therapy, metastasis, endocrine, Medicine
Abstract

Neoplasms arising from neuroendocrine cells form a heterogeneous group known as neuroendocrine tumors (NETs), which possess both endocrine and neural characteristics. These tumors can occur in various organs throughout the body, with the most prominent sites being the gastrointestinal tract, pancreas, and lungs. Despite their relatively low incidence, NETs have gained significant attention due to their unique biology and clinical behavior. This review intends to provide a widespread gestalt of the present perception of NETs, including their epidemiology, etiology, pathogenesis, classification, clinical presentation, diagnostic modalities, treatment options, and prognosis. Treatment strategies for NETs depend on tumor grade, stage, location, and functional status. Surgical resection remains the pillar of curative treatment for localized disease; on the other hand, systemic therapies take account of targeted therapies like tyrosine kinase inhibitors (TKIs), peptide receptor radionuclide therapy (PRRT), somatostatin analogs, and immunotherapy have shown promising results in advanced cases. In conclusion, this review provides an up-to-date summary of our current knowledge regarding neuroendocrine tumors. Further research is needed to better understand the underlying molecular mechanisms driving tumor development and progression. This will aid in developing novel therapeutic strategies targeting specific pathways involved in NET pathogenesis to improve patient outcomes.

Published
2024
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35. Data from NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma

Author

Panaccione, Alex, primary, Chang, Michael T., primary, Carbone, Beatrice E., primary, Guo, Yan, primary, Moskaluk, Christopher A., primary, Virk, Renu K., primary, Chiriboga, Luis, primary, Prasad, Manju L., primary, Judson, Benjamin, primary, Mehra, Saral, primary, Yarbrough, Wendell G., primary, and Ivanov, Sergey V., primary

Published
2023
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36. Supplemental Figure 6. from NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma

Author

Panaccione, Alex, primary, Chang, Michael T., primary, Carbone, Beatrice E., primary, Guo, Yan, primary, Moskaluk, Christopher A., primary, Virk, Renu K., primary, Chiriboga, Luis, primary, Prasad, Manju L., primary, Judson, Benjamin, primary, Mehra, Saral, primary, Yarbrough, Wendell G., primary, and Ivanov, Sergey V., primary

Published
2023
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37. Supplemental Table 4. from NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma

Author

Panaccione, Alex, primary, Chang, Michael T., primary, Carbone, Beatrice E., primary, Guo, Yan, primary, Moskaluk, Christopher A., primary, Virk, Renu K., primary, Chiriboga, Luis, primary, Prasad, Manju L., primary, Judson, Benjamin, primary, Mehra, Saral, primary, Yarbrough, Wendell G., primary, and Ivanov, Sergey V., primary

Published
2023
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38. Supplemental Figure 1. from NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma

Author

Panaccione, Alex, primary, Chang, Michael T., primary, Carbone, Beatrice E., primary, Guo, Yan, primary, Moskaluk, Christopher A., primary, Virk, Renu K., primary, Chiriboga, Luis, primary, Prasad, Manju L., primary, Judson, Benjamin, primary, Mehra, Saral, primary, Yarbrough, Wendell G., primary, and Ivanov, Sergey V., primary

Published
2023
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39. Supplemental Figure 2. from NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma

Author

Panaccione, Alex, primary, Chang, Michael T., primary, Carbone, Beatrice E., primary, Guo, Yan, primary, Moskaluk, Christopher A., primary, Virk, Renu K., primary, Chiriboga, Luis, primary, Prasad, Manju L., primary, Judson, Benjamin, primary, Mehra, Saral, primary, Yarbrough, Wendell G., primary, and Ivanov, Sergey V., primary

Published
2023
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40. Supplemental Figure 3. from NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma

Author

Panaccione, Alex, primary, Chang, Michael T., primary, Carbone, Beatrice E., primary, Guo, Yan, primary, Moskaluk, Christopher A., primary, Virk, Renu K., primary, Chiriboga, Luis, primary, Prasad, Manju L., primary, Judson, Benjamin, primary, Mehra, Saral, primary, Yarbrough, Wendell G., primary, and Ivanov, Sergey V., primary

Published
2023
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41. Supplemental Figure 5. from NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma

Author

Panaccione, Alex, primary, Chang, Michael T., primary, Carbone, Beatrice E., primary, Guo, Yan, primary, Moskaluk, Christopher A., primary, Virk, Renu K., primary, Chiriboga, Luis, primary, Prasad, Manju L., primary, Judson, Benjamin, primary, Mehra, Saral, primary, Yarbrough, Wendell G., primary, and Ivanov, Sergey V., primary

Published
2023
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42. Supplemental Table 1. from NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma

Author

Panaccione, Alex, primary, Chang, Michael T., primary, Carbone, Beatrice E., primary, Guo, Yan, primary, Moskaluk, Christopher A., primary, Virk, Renu K., primary, Chiriboga, Luis, primary, Prasad, Manju L., primary, Judson, Benjamin, primary, Mehra, Saral, primary, Yarbrough, Wendell G., primary, and Ivanov, Sergey V., primary

Published
2023
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43. Supplemental Table 3. from NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma

Author

Panaccione, Alex, primary, Chang, Michael T., primary, Carbone, Beatrice E., primary, Guo, Yan, primary, Moskaluk, Christopher A., primary, Virk, Renu K., primary, Chiriboga, Luis, primary, Prasad, Manju L., primary, Judson, Benjamin, primary, Mehra, Saral, primary, Yarbrough, Wendell G., primary, and Ivanov, Sergey V., primary

Published
2023
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44. Supplemental Figure 4. from NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma

Author

Panaccione, Alex, primary, Chang, Michael T., primary, Carbone, Beatrice E., primary, Guo, Yan, primary, Moskaluk, Christopher A., primary, Virk, Renu K., primary, Chiriboga, Luis, primary, Prasad, Manju L., primary, Judson, Benjamin, primary, Mehra, Saral, primary, Yarbrough, Wendell G., primary, and Ivanov, Sergey V., primary

Published
2023
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45. Supplemental Table 2. from NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma

Author

Panaccione, Alex, primary, Chang, Michael T., primary, Carbone, Beatrice E., primary, Guo, Yan, primary, Moskaluk, Christopher A., primary, Virk, Renu K., primary, Chiriboga, Luis, primary, Prasad, Manju L., primary, Judson, Benjamin, primary, Mehra, Saral, primary, Yarbrough, Wendell G., primary, and Ivanov, Sergey V., primary

Published
2023
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50. Supplemental Figure 6. from NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma

Author

Sergey V. Ivanov, Wendell G. Yarbrough, Saral Mehra, Benjamin Judson, Manju L. Prasad, Luis Chiriboga, Renu K. Virk, Christopher A. Moskaluk, Yan Guo, Beatrice E. Carbone, Michael T. Chang, and Alex Panaccione

Abstract

DAPT selectively increases cell death in CD133+ Accx11 cells as shown by PE-annexin and 7-AAD double staining. DMSO treatment serves as a control.

Published
2023
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