Search

Your search keyword '"Renner, Tobias J."' showing total 251 results
Start Over Author "Renner, Tobias J."
251 results on '"Renner, Tobias J."'

3. How to e-mental health: a guideline for researchers and practitioners using digital technology in the context of mental health

Author

Seiferth, Caroline, Vogel, Lea, Aas, Benjamin, Brandhorst, Isabel, Carlbring, Per, Conzelmann, Annette, Esfandiari, Narges, Finkbeiner, Marlene, Hollmann, Karsten, Lautenbacher, Heinrich, Meinzinger, Edith, Newbold, Alexandra, Opitz, Ansgar, Renner, Tobias J., Sander, Lasse Bosse, Santangelo, Philip S., Schoedel, Ramona, Schuller, Björn, Stachl, Clemens, Terhorst, Yannik, Torous, John, Wac, Katarzyna, Werner-Seidler, Aliza, Wolf, Sebastian, and Löchner, Johanna

Published
2023
Full Text
View/download PDF

6. Internet-based psychotherapy in children with obsessive-compulsive disorder (OCD): protocol of a randomized controlled trial

Author

Conzelmann, Annette, Hollmann, Karsten, Haigis, Anna, Lautenbacher, Heinrich, Bizu, Verena, App, Rehan, Nickola, Matthias, Wewetzer, Gunilla, Wewetzer, Christoph, Ivarsson, Tord, Skokauskas, Norbert, Wolters, Lidewij H., Skarphedinsson, Gudmundur, Weidle, Bernhard, de Haan, Else, Torp, Nor Christian, Compton, Scott N., Calvo, Rosa, Lera-Miguel, Sara, Alt, Annika, Hohnecker, Carolin Sarah, Allgaier, Katharina, and Renner, Tobias J.

Published
2022
Full Text
View/download PDF

8. Premorbid body weight predicts weight loss in both anorexia nervosa and atypical anorexia nervosa: Further support for a single underlying disorder

Author

Hebebrand, Johannes, primary, Seitz, Jochen, additional, Föcker, Manuel, additional, Viersen, Hanna Preuss‐van, additional, Huss, Michael, additional, Bühren, Katharina, additional, Dahmen, Brigitte, additional, Becker, Katja, additional, Weber, Linda, additional, Correll, Christoph U., additional, Jaite, Charlotte, additional, Egberts, Karin, additional, Romanos, Marcel, additional, Ehrlich, Stefan, additional, Seidel, Maria, additional, Roessner, Veit, additional, Fleischhaker, Christian, additional, Möhler, Eva, additional, Hahn, Freia, additional, Kaess, Michael, additional, Legenbauer, Tanja, additional, Hagmann, Daniela, additional, Renner, Tobias J., additional, Schulze, Ulrike M. E., additional, Thiemann, Ulf, additional, Wessing, Ida, additional, Antony, Gisela, additional, Herpertz‐Dahlmann, Beate, additional, Matthews, Abigail, additional, and Peters, Triinu, additional

Published
2024
Full Text
View/download PDF

10. Age dependency of body mass index distribution in childhood and adolescent inpatients with anorexia nervosa with a focus on DSM-5 and ICD-11 weight criteria and severity specifiers

Author

Engelhardt, Christian, Föcker, Manuel, Bühren, Katharina, Dahmen, Brigitte, Becker, Katja, Weber, Linda, Correll, Christoph U., Egberts, Karin Maria, Ehrlich, Stefan, Roessner, Veit, Fleischhaker, Christian, von Gontard, Alexander, Hahn, Freia, Jenetzky, Ekkehart, Kaess, Michael, Legenbauer, Tanja, Renner, Tobias J., Schulze, Ulrike M. E., Sinzig, Judith, Wessing, Ida, Antony, Gisela, Herpertz-Dahlmann, Beate, Peters, Triinu, and Hebebrand, Johannes

Published
2021
Full Text
View/download PDF

11. Reasons for admission and variance of body weight at referral in female inpatients with anorexia nervosa in Germany

Author

Peters, Triinu, Kolar, David, Föcker, Manuel, Bühren, Katharina, Dahmen, Brigitte, Becker, Katja, Weber, Linda, Correll, Christoph U., Jaite, Charlotte, Egberts, Karin M., Romanos, Marcel, Ehrlich, Stefan, Seidel, Maria, Roessner, Veit, Fleischhaker, Christian, von Gontard, Alexander, Hahn, Freia, Huss, Michael, Kaess, Michael, Legenbauer, Tanja, Renner, Tobias J., Schulze, Ulrike M. E., Sinzig, Judith, Wessing, Ida, Antony, Gisela, Herpertz-Dahlmann, Beate, Gradl-Dietsch, Gertraud, and Hebebrand, Johannes

Published
2021
Full Text
View/download PDF

12. Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture

Author

Davis, Lea K, Yu, Dongmei, Keenan, Clare L, Gamazon, Eric R, Konkashbaev, Anuar I, Derks, Eske M, Neale, Benjamin M, Yang, Jian, Lee, S. Hong, Evans, Patrick, Barr, Cathy L, Bellodi, Laura, Benarroch, Fortu, Berrio, Gabriel Bedoya, Bienvenu, Oscar J, Bloch, Michael H, Blom, Rianne M, Bruun, Ruth D, Budman, Cathy L, Camarena, Beatriz, Campbell, Desmond, Cappi, Carolina, Cardona Silgado, Julio C, Cath, Danielle C, Cavallini, Maria C, Chavira, Denise A, Chouinard, Sylvain, Conti, David V, Cook, Edwin H, Coric, Vladimir, Cullen, Bernadette A, Deforce, Dieter, Delorme, Richard, Dion, Yves, Edlund, Christopher K, Egberts, Karin, Falkai, Peter, Fernandez, Thomas V, Gallagher, Patience J, Garrido, Helena, Geller, Daniel, Girard, Simon L, Grabe, Hans J, Grados, Marco A, Greenberg, Benjamin D, Gross-Tsur, Varda, Haddad, Stephen, Heiman, Gary A, Hemmings, Sian M. J, Hounie, Ana G, Illmann, Cornelia, Jankovic, Joseph, Jenike, Michael A, Kennedy, James L, King, Robert A, Kremeyer, Barbara, Kurlan, Roger, Lanzagorta, Nuria, Leboyer, Marion, Leckman, James F, Lennertz, Leonhard, Liu, Chunyu, Lochner, Christine, Lowe, Thomas L, Macciardi, Fabio, McCracken, James T, McGrath, Lauren M, Mesa Restrepo, Sandra C, Moessner, Rainald, Morgan, Jubel, Muller, Heike, Murphy, Dennis L, Naarden, Allan L, Ochoa, William Cornejo, Ophoff, Roel A, Osiecki, Lisa, Pakstis, Andrew J, Pato, Michele T, Pato, Carlos N, Piacentini, John, Pittenger, Christopher, Pollak, Yehuda, Rauch, Scott L, Renner, Tobias J, Reus, Victor I, Richter, Margaret A, Riddle, Mark A, Robertson, Mary M, Romero, Roxana, Rosàrio, Maria C, Rosenberg, David, Rouleau, Guy A, Ruhrmann, Stephan, Ruiz-Linares, Andres, Sampaio, Aline S, Samuels, Jack, Sandor, Paul, Sheppard, Brooke, Singer, Harvey S, and Smit, Jan H

Subjects
Missing Heritability, Tic Disorders, Neuropsychiatric Disorders, Complex Diseases, Common Snps, Gilles, Family, Brain, Expression, Autism
Published
2013

13. High Loading of Polygenic Risk for ADHD in Children With Comorbid Aggression

Author

Hamshere, Marian L, Langley, Kate, Martin, Joanna, Agha, Sharifah Shameem, Stergiakouli, Evangelia, Anney, Richard JL, Buitelaar, Jan, Faraone, Stephen V, Lesch, Klaus-Peter, Neale, Benjamin M, Franke, Barbara, Sonuga-Barke, Edmund, Asherson, Philip, Merwood, Andrew, Kuntsi, Jonna, Medland, Sarah E, Ripke, Stephan, Steinhausen, Hans-Christoph, Freitag, Christine, Reif, Andreas, Renner, Tobias J, Romanos, Marcel, Romanos, Jasmin, Warnke, Andreas, Meyer, Jobst, Palmason, Haukur, Vasquez, Alejandro Arias, Lambregts-Rommelse, Nanda, Roeyers, Herbert, Biederman, Joseph, Doyle, Alysa E, Hakonarson, Hakon, Rothenberger, Aribert, Banaschewski, Tobias, Oades, Robert D, McGough, James J, Kent, Lindsey, Williams, Nigel, Owen, Michael J, Holmans, Peter, O’Donovan, Michael C, and Thapar, Anita

Subjects
Prevention, Behavioral and Social Science, Human Genome, Genetics, Mental Health, Attention Deficit Hyperactivity Disorder (ADHD), Clinical Research, Brain Disorders, Pediatric, Aetiology, 2.1 Biological and endogenous factors, Mental health, Aggression, Anxiety Disorders, Attention Deficit Disorder with Hyperactivity, Child, Child, Preschool, Comorbidity, Conduct Disorder, Depressive Disorder, Female, Genetic Predisposition to Disease, Genetic Variation, Humans, Male, Multifactorial Inheritance, United Kingdom, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

OBJECTIVE Although attention deficit hyperactivity disorder (ADHD) is highly heritable, genome-wide association studies (GWAS) have not yet identified any common genetic variants that contribute to risk. There is evidence that aggression or conduct disorder in children with ADHD indexes higher genetic loading and clinical severity. The authors examine whether common genetic variants considered en masse as polygenic scores for ADHD are especially enriched in children with comorbid conduct disorder. METHOD Polygenic scores derived from an ADHD GWAS meta-analysis were calculated in an independent ADHD sample (452 case subjects, 5,081 comparison subjects). Multivariate logistic regression analyses were employed to compare polygenic scores in the ADHD and comparison groups and test for higher scores in ADHD case subjects with comorbid conduct disorder relative to comparison subjects and relative to those without comorbid conduct disorder. Association with symptom scores was tested using linear regression. RESULTS Polygenic risk for ADHD, derived from the meta-analysis, was higher in the independent ADHD group than in the comparison group. Polygenic score was significantly higher in ADHD case subjects with conduct disorder relative to ADHD case subjects without conduct disorder. ADHD polygenic score showed significant association with comorbid conduct disorder symptoms. This relationship was explained by the aggression items. CONCLUSIONS Common genetic variation is relevant to ADHD, especially in individuals with comorbid aggression. The findings suggest that the previously published ADHD GWAS meta-analysis contains weak but true associations with common variants, support for which falls below genome-wide significance levels. The findings also highlight the fact that aggression in ADHD indexes genetic as well as clinical severity.

Published
2013

15. Genome-Wide Analysis of Copy Number Variants in Attention Deficit Hyperactivity Disorder: The Role of Rare Variants and Duplications at 15q13.3

Author

Williams, Nigel M, Franke, Barbara, Mick, Eric, Anney, Richard JL, Freitag, Christine M, Gill, Michael, Thapar, Anita, O'Donovan, Michael C, Owen, Michael J, Holmans, Peter, Kent, Lindsey, Middleton, Frank, Zhang-James, Yanli, Liu, Lu, Meyer, Jobst, Nguyen, Thuy Trang, Romanos, Jasmin, Romanos, Marcel, Seitz, Christiane, Renner, Tobias J, Walitza, Susanne, Warnke, Andreas, Palmason, Haukur, Buitelaar, Jan, Rommelse, Nanda, Vasquez, Alejandro Arias, Hawi, Ziarih, Langley, Kate, Sergeant, Joseph, Steinhausen, Hans-Christoph, Roeyers, Herbert, Biederman, Joseph, Zaharieva, Irina, Hakonarson, Hakon, Elia, Josephine, Lionel, Anath C, Crosbie, Jennifer, Marshall, Christian R, Schachar, Russell, Scherer, Stephen W, Todorov, Alexandre, Smalley, Susan L, Loo, Sandra, Nelson, Stanley, Shtir, Corina, Asherson, Philip, Reif, Andreas, Lesch, Klaus-Peter, and Faraone, Stephen V

Subjects
Human Genome, Clinical Research, Mental Health, Genetics, Pediatric, Attention Deficit Hyperactivity Disorder (ADHD), Brain Disorders, Serious Mental Illness, 2.1 Biological and endogenous factors, Aetiology, Adolescent, Attention Deficit Disorder with Hyperactivity, Canada, Causality, Child, Child, Preschool, Female, Gene Dosage, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, In Situ Hybridization, Fluorescence, Inheritance Patterns, Polymorphism, Single Nucleotide, Receptors, Nicotinic, Segmental Duplications, Genomic, United Kingdom, United States, alpha7 Nicotinic Acetylcholine Receptor, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

ObjectiveAttention deficit hyperactivity disorder (ADHD) is a common, highly heritable psychiatric disorder. Because of its multifactorial etiology, however, identifying the genes involved has been difficult. The authors followed up on recent findings suggesting that rare copy number variants (CNVs) may be important for ADHD etiology.MethodThe authors performed a genome-wide analysis of large, rare CNVs (100 kb in size, which segregated into 912 independent loci. Overall, the rate of rare CNVs >100 kb was 1.15 times higher in ADHD case subjects relative to comparison subjects, with duplications spanning known genes showing a 1.2-fold enrichment. In accordance with a previous study, rare CNVs >500 kb showed the greatest enrichment (1.28-fold). CNVs identified in ADHD case subjects were significantly enriched for loci implicated in autism and in schizophrenia. Duplications spanning the CHRNA7 gene at chromosome 15q13.3 were associated with ADHD in single-locus analysis. This finding was consistently replicated in an additional 2,242 ADHD case subjects and 8,552 comparison subjects from four independent cohorts from the United Kingdom, the United States, and Canada. Presence of the duplication at 15q13.3 appeared to be associated with comorbid conduct disorder.ConclusionsThese findings support the enrichment of large, rare CNVs in ADHD and implicate duplications at 15q13.3 as a novel risk factor for ADHD. With a frequency of 0.6% in the populations investigated and a relatively large effect size (odds ratio=2.22, 95% confidence interval=1.5–3.6), this locus could be an important contributor to ADHD etiology.

Published
2012

18. Patients' well-being during the transition period after psychiatric hospitalization to school: insights from an intensive longitudinal assessment of patient–parent–teacher triads.

Author

Finkbeiner, Marlene, Wahl, Lena-Marie, Kühnhausen, Jan, Schmid, Johanna, Hellwig, Leona, Brenner, Vera, Dürrwächter, Ute, Conzelmann, Annette, Kelava, Augustin, Renner, Tobias J., and Gawrilow, Caterina

Subjects
PSYCHIATRIC hospital care, WELL-being, SCHOOL day, SELF-efficacy in teachers, PSYCHIATRIC hospitals
Abstract

Background: The transition period after psychiatric hospitalization back to school is accompanied by various challenges, including a substantial risk for rehospitalization. Self-efficacy and self-control, as transdiagnostic variables and important predictors of coping with school demands, should be crucial factors for successful adaptation processes as well as an overall high well-being during school reentry. The present study therefore investigates how patients' well-being develops during this period, and how it is related to patients' self-control and academic self-efficacy, as well as parents' and teachers' self-efficacy in dealing with the patient. Methods: In an intensive longitudinal design, daily ambulatory assessment measures via smartphone were collected with self-reports from the triadic perspective of 25 patients (Mage = 10.58 years), 24 parents, and 20 teachers on 50 consecutive school days, starting 2 weeks before discharge from a psychiatric day hospital (mean compliance rate: 71% for patients, 72% for parents and 43% for teachers). Patients answered daily questions between five and nine o'clock in the evening about their well-being, self-control, academic self-efficacy and about positive and negative events at school, as well as parents and teachers about their self-efficacy in dealing with the patient. Results: Multilevel modeling revealed that on average, patients' well-being and self-control decreased during the transition period, with trends over time differing significantly between patients. While patients' academic self-efficacy did not systematically decrease over time, it did show considerable intra-individual fluctuation. Importantly, patients experienced higher well-being on days with higher self-control and academic self-efficacy as well as with higher parental self-efficacy. Daily teacher self-efficacy did not show a significant within-person relationship to daily patients' well-being. Conclusions: Well-being in the transition period is related to self-control and self-efficacy of patients and their parents. Thus, addressing patients' self-control and academic self-efficacy, as well as parental self-efficacy, seems promising to enhance and stabilize well-being of patients during transition after psychiatric hospitalization. Trial registration Not applicable, as no health care intervention was conducted. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

20. Multimodal Sensor-Based Identification of Stress and Compulsive Actions in Children with Obsessive-Compulsive Disorder for Telemedical Treatment

Author

Thierfelder, Annika, primary, Primbs, Jonas, additional, Severitt, Bjorn, additional, Hohnecker, Carolin S., additional, Kuhnhausen, Jan, additional, Alt, Annika K., additional, Pascher, Anja, additional, Worz, Ursula, additional, Passon, Helene, additional, Seemann, Jens, additional, Ernst, Christian, additional, Lautenbacher, Heinrich, additional, Holderried, Martin, additional, Kasneci, Enkelejda, additional, Giese, Martin A., additional, Bulling, Andreas, additional, Menth, Michael, additional, Barth, Gottfried M., additional, Ilg, Winfried, additional, Hollmann, Karsten, additional, and Renner, Tobias J., additional

Published
2022
Full Text
View/download PDF

23. Meta-Analysis of Genome-Wide Association Studies of Attention-Deficit/Hyperactivity Disorder

Author

Neale, Benjamin M., Medland, Sarah E., Ripke, Stephan, Asherson, Philip, Franke, Barbara, Lesch, Klaus-Peter, Faraone, Stephen V., Nguyen, Thuy Trang, Schafer, Helmut, Holmans, Peter, Daly, Mark, Steinhausen, Hans-Christoph, Freitag, Christine, Reif, Andreas, Renner, Tobias J., Romanos, Marcel, Romanos, Jasmin, Walitza, Susanne, Warnke, Andreas, Meyer, Jobst, Palmason, Haukur, Buitelaar, Jan, Vasquez, Alejandro Arias, Lambregts-Rommelse, Nanda, Gill, Michael, Anney, Richard J. L., Langely, Kate, O'Donovan, Michael, Williams, Nigel, Owen, Michael, Thapar, Anita, Kent, Lindsey, Sergeant, Joseph, Roeyers, Herbert, Mick, Eric, Biederman, Joseph, Doyle, Alysa, Smalley, Susan, Loo, Sandra, Hakonarson, Hakon, Elia, Josephine, Todorov, Alexandre, Miranda, Ana, Mulas, Fernando, Ebstein, Richard P., Rothenberger, Aribert, Banaschewski, Tobias, Oades, Robert D., Sonuga-Barke, Edmund, McGough, James, Nisenbaum, Laura, Middleton, Frank, Hu, Xiaolan, and Nelson, Stan

Abstract

Objective: Although twin and family studies have shown attention-deficit/hyperactivity disorder (ADHD) to be highly heritable, genetic variants influencing the trait at a genome-wide significant level have yet to be identified. As prior genome-wide association studies (GWAS) have not yielded significant results, we conducted a meta-analysis of existing studies to boost statistical power. Method: We used data from four projects: a) the Children's Hospital of Philadelphia (CHOP); b) phase I of the International Multicenter ADHD Genetics project (IMAGE); c) phase II of IMAGE (IMAGE II); and d) the Pfizer-funded study from the University of California, Los Angeles, Washington University, and Massachusetts General Hospital (PUWMa). The final sample size consisted of 2,064 trios, 896 cases, and 2,455 controls. For each study, we imputed HapMap single nucleotide polymorphisms, computed association test statistics and transformed them to z-scores, and then combined weighted z-scores in a meta-analysis. Results: No genome-wide significant associations were found, although an analysis of candidate genes suggests that they may be involved in the disorder. Conclusions: Given that ADHD is a highly heritable disorder, our negative results suggest that the effects of common ADHD risk variants must, individually, be very small or that other types of variants, e.g., rare ones, account for much of the disorder's heritability. (Contains 3 figures and 3 tables.)

Published
2010
Full Text
View/download PDF

26. Case-Control Genome-Wide Association Study of Attention-Deficit/Hyperactivity Disorder

Author

Neale, Benjamin M., Medland, Sarah, Ripke, Stephan, Anney, Richard J.L., Asherson, Philip, Buitelaar, Jan, Franke, Barbara, Gill, Michael, Kent, Lindsey, Holmans, Peter, Middleton, Frank, Thapar, Anita, Lesch, Klaus-Peter, Faraone, Stephen V., Daly, Mark, Nguyen, Thuy Trang, Schäfer, Helmut, Steinhausen, Hans-Christoph, Reif, Andreas, Renner, Tobias J., Romanos, Marcel, Romanos, Jasmin, Warnke, Andreas, Walitza, Susanne, Freitag, Christine, Meyer, Jobst, Palmason, Haukur, Rothenberger, Aribert, Hawi, Ziarih, Sergeant, Joseph, Roeyers, Herbert, Mick, Eric, and Biederman, Joseph

Published
2010
Full Text
View/download PDF

28. Internet-based cognitive behavioral therapy in children and adolescents with obsessive compulsive disorder: a feasibility study

Author

Hollmann, Karsten, primary, Allgaier, Katharina, additional, Hohnecker, Carolin S., additional, Lautenbacher, Heinrich, additional, Bizu, Verena, additional, Nickola, Matthias, additional, Wewetzer, Gunilla, additional, Wewetzer, Christoph, additional, Ivarsson, Tord, additional, Skokauskas, Norbert, additional, Wolters, Lidewij H., additional, Skarphedinsson, Gudmundur, additional, Weidle, Bernhard, additional, de Haan, Else, additional, Torp, Nor Christan, additional, Compton, Scott N., additional, Calvo, Rosa, additional, Lera-Miguel, Sara, additional, Haigis, Anna, additional, Renner, Tobias J., additional, and Conzelmann, Annette, additional

Published
2021
Full Text
View/download PDF

31. Influence of functional variant of neuronal nitric oxide synthase on impulsive behaviors in humans

Author

Reif, Andreas, Jacob, Christian P., Rujescu, Dan, Herterich, Sabine, Lang, Sebastian, Gutknecht, Lise, Baehne, Christina G., Strobel, Alexander, Freitag, Christine M., Giegling, Ina, Romanos, Marcel, Hartmann, Annette, Rosler, Michael, Renner, Tobias J., Fallgatter, Andreas J., Retz, Wolfgang, Ehlis, Ann-Christine, and Lesch, Klaus-Peter

Subjects
Impulse -- Genetic aspects, Impulse -- Physiological aspects, Impulse -- Research, Genetic variation -- Research, Nitric oxide -- Genetic aspects, Nitric oxide -- Research, Health, Psychology and mental health
Published
2009

32. No Association of Variants of the NPY-System With Obsessive-Compulsive Disorder in Children and Adolescents

Author

Franke, Maximilian, Conzelmann, Annette, Grünblatt, Edna, Werling, Anna M., Spieles, Helen, Wewetzer, Christoph, Warnke, Andreas, Romanos, Marcel, Walitza, Susanne, Renner, Tobias J., University of Zurich, and Renner, Tobias J

Subjects
Cellular and Molecular Neuroscience, 1312 Molecular Biology, 2804 Cellular and Molecular Neuroscience, 610 Medicine & health, 10058 Department of Child and Adolescent Psychiatry, Molecular Biology
Published
2019

38. Common obesity risk alleles in childhood attention-deficit/hyperactivity disorder

Author

Albayrak, Özgür, Pütter, Carolin, Volckmar, Anna-Lena, Cichon, Sven, Hoffmann, Per, Nöthen, Markus M., Jöckel, Karl-Heinz, Schreiber, Stefan, Wichmann, H-Erich, Faraone, Stephen V., Neale, Benjamin M., Herpertz-Dahlmann, Beate, Lehmkuhl, Gerd, Sinzig, Judith, Renner, Tobias J., Romanos, Marcel, Warnke, Andreas, Lesch, Klaus-Peter, Reif, Andreas, Schimmelmann, Benno G., Scherag, André, Hebebrand, Johannes, and Hinney, Anke

Published
2013
Full Text
View/download PDF

39. Genome-wide association study in German patients with attention deficit/hyperactivity disorder

Author

Hinney, Anke, Scherag, André, Jarick, Ivonne, Albayrak, Özgür, Pütter, Carolin, Pechlivanis, Sonali, Dauvermann, Maria R., Beck, Sebastian, Weber, Heike, Scherag, Susann, Nguyen, Trang T., Volckmar, Anna-Lena, Knoll, Nadja, Faraone, Stephen V., Neale, Benjamin M., Franke, Barbara, Cichon, Sven, Hoffmann, Per, Nöthen, Markus M., Schreiber, Stefan, Jöckel, Karl-Heinz, Wichmann, H.-Erich, Freitag, Christine, Lempp, Thomas, Meyer, Jobst, Gilsbach, Susanne, Herpertz-Dahlmann, Beate, Sinzig, Judith, Lehmkuhl, Gerd, Renner, Tobias J., Warnke, Andreas, Romanos, Marcel, Lesch, Klaus-Peter, Reif, Andreas, Schimmelmann, Benno G., and Hebebrand, Johannes

Published
2011
Full Text
View/download PDF

43. Age dependency of body mass index distribution in childhood and adolescent inpatients with anorexia nervosa with a focus on DSM-5 and ICD-11 weight criteria and severity specifiers

Author

Engelhardt, Christian, primary, Föcker, Manuel, additional, Bühren, Katharina, additional, Dahmen, Brigitte, additional, Becker, Katja, additional, Weber, Linda, additional, Correll, Christoph U., additional, Egberts, Karin Maria, additional, Ehrlich, Stefan, additional, Roessner, Veit, additional, Fleischhaker, Christian, additional, von Gontard, Alexander, additional, Hahn, Freia, additional, Jenetzky, Ekkehart, additional, Kaess, Michael, additional, Legenbauer, Tanja, additional, Renner, Tobias J., additional, Schulze, Ulrike M. E., additional, Sinzig, Judith, additional, Wessing, Ida, additional, Antony, Gisela, additional, Herpertz-Dahlmann, Beate, additional, Peters, Triinu, additional, and Hebebrand, Johannes, additional

Published
2020
Full Text
View/download PDF

45. Clinical Characteristics of Inpatients with Childhood vs. Adolescent Anorexia Nervosa

Author

Jaite, Charlotte, Bühren, Katharina Inga, Dahmen, Brigitte, Dempfle, Astrid, Becker, Katja, Correll, Christoph U., Egberts, Karin M., Ehrlich, Stefan, Fleischhaker, Christian, Von Gontard, Alexander, Hahn, Freia, Kolar, David, Kaess, Michael, Legenbauer, Tanja, Renner, Tobias J., Schulze, Ulrike, Sinzig, Judith, Thomae, Ellen, Weber, Linda, Wessing, Ida, Antony, Gisela, Hebebrand, Johannes, Föcker, Manuel, and Herpertz-Dahlmann, Beate

Subjects
Male, Aging, Inpatients, Adolescent, Medizin, lcsh:TX341-641, 610 Medicine & health, Patient Discharge, Article, anorexia nervosa, Hospitalization, BMI, children, outcome, Humans, Female, ddc:610, adolescents, Child, lcsh:Nutrition. Foods and food supply, clinical characteristics, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
Abstract

We aimed to compare the clinical data at first presentation to inpatient treatment of children (&lt, 14 years) vs. adolescents (&ge, 14 years) with anorexia nervosa (AN), focusing on duration of illness before hospital admission and body mass index (BMI) at admission and discharge, proven predictors of the outcomes of adolescent AN. Clinical data at first admission and at discharge in 289 inpatients with AN (children: n = 72, adolescents: n = 217) from a German multicenter, web-based registry for consecutively enrolled patients with childhood and adolescent AN were analyzed. Inclusion criteria were a maximum age of 18 years, first inpatient treatment due to AN, and a BMI &lt, 10th BMI percentile at admission. Compared to adolescents, children with AN had a shorter duration of illness before admission (median: 6.0 months vs. 8.0 months, p = 0.004) and higher BMI percentiles at admission (median: 0.7 vs. 0.2, p = 0.004) as well as at discharge (median: 19.3 vs. 15.1, p = 0.011). Thus, in our study, children with AN exhibited clinical characteristics that have been associated with better outcomes, including higher admission and discharge BMI percentile. Future studies should examine whether these factors are actually associated with positive long-term outcomes in children.

Published
2019
Full Text
View/download PDF

46. Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

Author

Demontis, Ditte, Walters, Raymond K., Martin, Joanna, Mattheisen, Manuel, Als, Thomas D., Agerbo, Esben, Baldursson, Gisli, Belliveau, Rich, Bybjerg-Grauholm, Jonas, Baekvad-Hansen, Marie, Cerrato, Felecia, Chambert, Kimberly, Churchhouse, Claire, Dumont, Ashley, Eriksson, Nicholas, Gandal, Michael, Goldstein, Jacqueline I., Grasby, Katrina L., Grove, Jakob, Gudmundsson, Olafur O., Hansen, Christine S., Hauberg, Mads Engel, Hollegaard, Mads V., Howrigan, Daniel P., Huang, Hailiang, Maller, Julian B., Martin, Alicia R., Martin, Nicholas G., Moran, Jennifer, Pallesen, Jonatan, Palmer, Duncan S., Pedersen, Carsten Bocker, Pedersen, Marianne Giortz, Poterba, Timothy, Poulsen, Jesper Buchhave, Ripke, Stephan, Robinson, Elise B., Satterstrom, F. Kyle, Stefansson, Hreinn, Stevens, Christine, Turley, Patrick, Walters, G. Bragi, Won, Hyejung, Wright, Margaret J., Andreassen, Ole A., Asherson, Philip, Burton, Christie L., Boomsma, Dorret I., Cormand, Bru, Dalsgaard, Soren, Franke, Barbara, Gelernter, Joel, Geschwind, Daniel, Hakonarson, Hakon, Haavik, Jan, Kranzler, Henry R., Kuntsi, Jonna, Langley, Kate, Lesch, Klaus-Peter, Middeldorp, Christel, Reif, Andreas, Rohde, Luis Augusto, Roussos, Panos, Schachar, Russell, Sklar, Pamela, Sonuga-Barke, Edmund J. S., Sullivan, Patrick F., Thapar, Anita, Tung, Joyce Y., Waldman, Irwin D., Medland, Sarah E., Stefansson, Kari, Nordentoft, Merete, Hougaard, David M., Werge, Thomas, Mors, Ole, Mortensen, Preben Bo, Daly, Mark J., Faraone, Stephen V., Borglum, Anders D., Neale, Benjamin M., Albayrak, Ozgur, Anney, Richard J. L., Arranz, Maria Jesus, Banaschewski, Tobias J., Bau, Claiton, Biederman, Joseph, Buitelaar, Jan K., Casas, Miguel, Charach, Alice, Crosbie, Jennifer, Dempfle, Astrid, Doyle, Alysa E., Ebstein, Richard P., Elia, Josephine, Freitag, Christine, Focker, Manuel, Gill, Michael, Grevet, Eugenio, Hawi, Ziarih, Hebebrand, Johannes, Herpertz-Dahlmann, Beate, Hervas, Amaia, Hinney, Anke, Hohmann, Sarah, Holmans, Peter, Hutz, Mara, Ickowitz, Abel, Johansson, Stefan, Kent, Lindsey, Kittel-Schneider, Sarah, Lambregts-Rommelse, Nanda, Lehmkuhl, Gerd, Loo, Sandra K., McGough, James J., Meyer, Jobst, Mick, Eric, Middletion, Frank, Miranda, Ana, Mota, Nina Roth, Mulas, Fernando, Mulligan, Aisling, Nelson, Freimer, Nguyen, T. Trang, Oades, Robert D., O'Donovan, Michael C., Owen, Michael J., Palmason, Haukur, Ramos-Quiroga, Josep Antoni, Renner, Tobias J., Ribases, Marta, Rietschel, Marcella, Rivero, Olga, Romanos, Jasmin, Romanos, Marcel, Rothenberger, Aribert, Royers, Herbert, Sanchez-Mora, Christina, Scherag, Andre, Schimmelmann, Benno G., Schafer, Helmut, Sergeant, Joseph, Sinzig, Judith, Smalley, Susan L., Steinhausen, Hans-Christoph, Thompson, Margaret, Todorov, Alexandre, Vasquez, Alejandro Arias, Walitza, Susanne, Wang, Yufeng, Warnke, Andreas, Williams, Nigel, Witt, Stephanie H., Yang, Li, Zayats, Tetyana, Zhang-James, Yanli, Smith, George Davey, Davies, Gareth E., Ehli, Erik A., Evans, David M., Fedko, Iryna O., Greven, Corina U., Groen-Blokhuis, Maria M., Guxens, Monica, Hammerschlag, Anke R., Hartman, Catharina A., Heinrich, Joachim, Hottenga, Jouke Jan, Hudziak, James, Jugessur, Astanand, Kemp, John P., Krapohl, Eva, Murcia, Mario, Myhre, Ronny, Nolte, Ilja M., Nyholt, Dale R., Ormel, Johan, Ouwens, Klaasjan G., Pappa, Irene, Pennell, Craig E., Plomin, Robert, Ring, Susan, Standl, Marie, Stergiakouli, Evie, St Pourcain, Beate, Stoltenberg, Camilla, Sunyer, Jordi, Thiering, Elisabeth, Tiemeier, Henning, Tiesler, Carla M. T., Timpson, Nicholas J., Trzaskowski, Maciej, van der Most, Peter Johannes, Vilor-Tejedor, Natalia, Wang, Carol A., Whitehouse, Andrew J. O., Zhao, Huiying, Agee, Michelle, Alipanahi, Babak, Auton, Adam, Bell, Robert K., Bryc, Katarzyna, Elson, Sarah L., Fontanillas, Pierre, Furlotte, Nicholas A., Hinds, David A., Hromatka, Bethann S., Huber, Karen E., Kleinman, Aaron, Litterman, Nadia K., McIntyre, Matthew H., Mountain, Joanna L., Northover, Carrie A. M., Pitts, Steven J., Sathirapongsasuti, J. Fah, Sazonova, Olga V., Shelton, Janie F., Shringarpure, Suyash, Tian, Chao, Vacic, Vladimir, Wilson, Catherine H., Demontis, Ditte, Walters, Raymond K., Martin, Joanna, Mattheisen, Manuel, Als, Thomas D., Agerbo, Esben, Baldursson, Gisli, Belliveau, Rich, Bybjerg-Grauholm, Jonas, Baekvad-Hansen, Marie, Cerrato, Felecia, Chambert, Kimberly, Churchhouse, Claire, Dumont, Ashley, Eriksson, Nicholas, Gandal, Michael, Goldstein, Jacqueline I., Grasby, Katrina L., Grove, Jakob, Gudmundsson, Olafur O., Hansen, Christine S., Hauberg, Mads Engel, Hollegaard, Mads V., Howrigan, Daniel P., Huang, Hailiang, Maller, Julian B., Martin, Alicia R., Martin, Nicholas G., Moran, Jennifer, Pallesen, Jonatan, Palmer, Duncan S., Pedersen, Carsten Bocker, Pedersen, Marianne Giortz, Poterba, Timothy, Poulsen, Jesper Buchhave, Ripke, Stephan, Robinson, Elise B., Satterstrom, F. Kyle, Stefansson, Hreinn, Stevens, Christine, Turley, Patrick, Walters, G. Bragi, Won, Hyejung, Wright, Margaret J., Andreassen, Ole A., Asherson, Philip, Burton, Christie L., Boomsma, Dorret I., Cormand, Bru, Dalsgaard, Soren, Franke, Barbara, Gelernter, Joel, Geschwind, Daniel, Hakonarson, Hakon, Haavik, Jan, Kranzler, Henry R., Kuntsi, Jonna, Langley, Kate, Lesch, Klaus-Peter, Middeldorp, Christel, Reif, Andreas, Rohde, Luis Augusto, Roussos, Panos, Schachar, Russell, Sklar, Pamela, Sonuga-Barke, Edmund J. S., Sullivan, Patrick F., Thapar, Anita, Tung, Joyce Y., Waldman, Irwin D., Medland, Sarah E., Stefansson, Kari, Nordentoft, Merete, Hougaard, David M., Werge, Thomas, Mors, Ole, Mortensen, Preben Bo, Daly, Mark J., Faraone, Stephen V., Borglum, Anders D., Neale, Benjamin M., Albayrak, Ozgur, Anney, Richard J. L., Arranz, Maria Jesus, Banaschewski, Tobias J., Bau, Claiton, Biederman, Joseph, Buitelaar, Jan K., Casas, Miguel, Charach, Alice, Crosbie, Jennifer, Dempfle, Astrid, Doyle, Alysa E., Ebstein, Richard P., Elia, Josephine, Freitag, Christine, Focker, Manuel, Gill, Michael, Grevet, Eugenio, Hawi, Ziarih, Hebebrand, Johannes, Herpertz-Dahlmann, Beate, Hervas, Amaia, Hinney, Anke, Hohmann, Sarah, Holmans, Peter, Hutz, Mara, Ickowitz, Abel, Johansson, Stefan, Kent, Lindsey, Kittel-Schneider, Sarah, Lambregts-Rommelse, Nanda, Lehmkuhl, Gerd, Loo, Sandra K., McGough, James J., Meyer, Jobst, Mick, Eric, Middletion, Frank, Miranda, Ana, Mota, Nina Roth, Mulas, Fernando, Mulligan, Aisling, Nelson, Freimer, Nguyen, T. Trang, Oades, Robert D., O'Donovan, Michael C., Owen, Michael J., Palmason, Haukur, Ramos-Quiroga, Josep Antoni, Renner, Tobias J., Ribases, Marta, Rietschel, Marcella, Rivero, Olga, Romanos, Jasmin, Romanos, Marcel, Rothenberger, Aribert, Royers, Herbert, Sanchez-Mora, Christina, Scherag, Andre, Schimmelmann, Benno G., Schafer, Helmut, Sergeant, Joseph, Sinzig, Judith, Smalley, Susan L., Steinhausen, Hans-Christoph, Thompson, Margaret, Todorov, Alexandre, Vasquez, Alejandro Arias, Walitza, Susanne, Wang, Yufeng, Warnke, Andreas, Williams, Nigel, Witt, Stephanie H., Yang, Li, Zayats, Tetyana, Zhang-James, Yanli, Smith, George Davey, Davies, Gareth E., Ehli, Erik A., Evans, David M., Fedko, Iryna O., Greven, Corina U., Groen-Blokhuis, Maria M., Guxens, Monica, Hammerschlag, Anke R., Hartman, Catharina A., Heinrich, Joachim, Hottenga, Jouke Jan, Hudziak, James, Jugessur, Astanand, Kemp, John P., Krapohl, Eva, Murcia, Mario, Myhre, Ronny, Nolte, Ilja M., Nyholt, Dale R., Ormel, Johan, Ouwens, Klaasjan G., Pappa, Irene, Pennell, Craig E., Plomin, Robert, Ring, Susan, Standl, Marie, Stergiakouli, Evie, St Pourcain, Beate, Stoltenberg, Camilla, Sunyer, Jordi, Thiering, Elisabeth, Tiemeier, Henning, Tiesler, Carla M. T., Timpson, Nicholas J., Trzaskowski, Maciej, van der Most, Peter Johannes, Vilor-Tejedor, Natalia, Wang, Carol A., Whitehouse, Andrew J. O., Zhao, Huiying, Agee, Michelle, Alipanahi, Babak, Auton, Adam, Bell, Robert K., Bryc, Katarzyna, Elson, Sarah L., Fontanillas, Pierre, Furlotte, Nicholas A., Hinds, David A., Hromatka, Bethann S., Huber, Karen E., Kleinman, Aaron, Litterman, Nadia K., McIntyre, Matthew H., Mountain, Joanna L., Northover, Carrie A. M., Pitts, Steven J., Sathirapongsasuti, J. Fah, Sazonova, Olga V., Shelton, Janie F., Shringarpure, Suyash, Tian, Chao, Vacic, Vladimir, and Wilson, Catherine H.

Abstract

Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute substantially to ADHD susceptibility, but no variants have been robustly associated with ADHD. We report a genome-wide association meta-analysis of 20,183 individuals diagnosed with ADHD and 35,191 controls that identifies variants surpassing genome-wide significance in 12 independent loci, finding important new information about the underlying biology of ADHD. Associations are enriched in evolutionarily constrained genomic regions and loss-of-function intolerant genes and around brain-expressed regulatory marks. Analyses of three replication studies: a cohort of individuals diagnosed with ADHD, a self-reported ADHD sample and a meta-analysis of quantitative measures of ADHD symptoms in the population, support these findings while highlighting study-specific differences on genetic overlap with educational attainment. Strong concordance with GWAS of quantitative population measures of ADHD symptoms supports that clinical diagnosis of ADHD is an extreme expression of continuous heritable traits.

Published
2019

48. A genetic investigation of sex bias in the prevalence of attention-deficit/hyperactivity disorder

Author

Martin, Joanna, Walters, Raymond K., Demontis, Ditte, Mattheisen, Manuel, Lee, S. Hong, Robinson, Elise, Brikell, Isabell, Ghirardi, Laura, Larsson, Henrik, Lichtenstein, Paul, Eriksson, Nicholas, Werge, Thomas, Mortensen, Preben Bo, Pedersen, Marianne Giørtz, Mors, Ole, Nordentoft, Merete, Hougaard, David M., Bybjerg-Grauholm, Jonas, Wray, Naomi R., Franke, Barbara, Faraone, Stephen V., O'Donovan, Michael, Thapar, Anita, Børglum, Anders D., Neale, Benjamin M., Agee, Michelle, Alipanahi, Babak, Auton, Adam, Bell, Robert K., Bryc, Katarzyna, Elson, Sarah L., Fontanillas, Pierre, Furlotte, Nicholas A., Hinds, David A., Hromatka, Bethann S., Huber, Karen E., Kleinman, Aaron, Litterman, Nadia K., McIntyre, Matthew H., Mountain, Joanna L., Northover, Carrie A.M., Pitts, Steven J., Sathirapongsasuti, J. Fah, Sazonova, Olga V., Shelton, Janie F., Shringarpure, Suyash, Tian, Chao, Tung, Joyce Y., Vacic, Vladimir, Wilson, Catherine H., Albayrak, Özgür, Anney, Richard J. L., Vasquez, Alejandro Arias, Arranz, Maria Jesús, Asherson, Philip, Banaschewski, Tobias, Banaschewski, Tobias J., Bau, Claiton, Biederman, Joseph, Buitelaar, Jan K., Casas, Miguel, Charach, Alice, Cormand, Bru, Crosbie, Jennifer, Dalsgaard, Soeren, Daly, Mark J., Dempfle, Astrid, Doyle, Alysa E., Ebstein, Richard P., Elia, Josephine, Föcker, Manuel, Freitag, Christine, Gelernter, Joel, Gill, Michael, Grevet, Eugenio, Haavik, Jan, Hakonarson, Hakon, Hawi, Ziarih, Hebebrand, Johannes, Herpertz-Dahlmann, Beate, Hervas, Amaia, Hinney, Anke, Hohmann, Sarah, Holmans, Peter, Hutz, Mara, Ickowitz, Abel, Johansson, Stefan, Kent, Lindsey, Kittel-Schneider, Sarah, Kranzler, Henry, Kuntsi, Jonna, Lambregts-Rommelse, Nanda, Langley, Kate, Lehmkuhl, Gerd, Lesch, Klaus-Peter, Loo, Sandra K., McGough, James J., Medland, Sarah E., Meyer, Jobst, Mick, Eric, Middletion, Frank, Miranda, Ana, Mulas, Fernando, Mulligan, Aisling, Nelson, Stan F., Nguyen, T. Trang, Oades, Robert D., Palmason, Haukur, Ramos-Quiroga, Josep Antoni, Reif, Andreas, Renner, Tobias J., Rhode, Luis, Ribasés, Marta, Rietschel, Marcella, Ripke, Stephan, Rivero, Olga, Sánchez-Mora, Cristina, Schachar, Russell, Schäfer, Helmut, Scherag, André, Schimmelmann, Benno G., Sergeant, Joseph, Sinzig, Judith, Smalley, Susan L., Sonuga-Barke, Edmund J.S., Steinhausen, Hans-Christoph, Sullivan, Patrick F., Thompsom, Margaret, Todorov, Alexandre, Waldman, Irwin, Walitza, Susanne, Wang, Yufeng, Warnke, Andreas, Williams, Nigel, Witt, Stephanie H., Yang, Li, Zayats, Tetyana, Zhang-James, Yanli, Agerbo, Esben, Damm Als, Thomas, Bækved-Hansen, Marie, Belliveau, Rich, Cerrato, Felecia, Chambert, Kimberly, Churchhouse, Claire, Dalsgaard, Søren, Dumont, Ashley, Goldstein, Jacqueline, Grove, Jakob, Hansen, Christine S., Engel Hauberg, Mads, Hollegaard, Mads V., Howrigan, Daniel P., Huang, Hailiang, Maller, Julian, Martin, Alicia R., Moran, Jennifer, Pallesen, Jonatan, Palmer, Duncan S., Pedersen, Carsten Bøcker, Poterba, Timothy, Poulson, Jesper Buchhave, Robinson, Elise B., Satterstrom, F. Kyle, Stevens, Christine, and Turley, Patrick

Abstract

Background Attention-deficit/hyperactivity disorder (ADHD) shows substantial heritability and is 2-7 times more common in males than females. We examined two putative genetic mechanisms underlying this sex bias: sex-specific heterogeneity and higher burden of risk in female cases. Methods We analyzed genome-wide autosomal common variants from the Psychiatric Genomics Consortium and iPSYCH Project (20,183 cases, 35,191 controls) and Swedish populationregister data (N=77,905 cases, N=1,874,637 population controls). Results Genetic correlation analyses using two methods suggested near complete sharing of common variant effects across sexes, with rg estimates close to 1. Analyses of population data, however, indicated that females with ADHD may be at especially high risk of certain comorbid developmental conditions (i.e. autism spectrum disorder and congenital malformations), potentially indicating some clinical and etiological heterogeneity. Polygenic risk score (PRS) analysis did not support a higher burden of ADHD common risk variants in female cases (OR=1.02 [0.98-1.06], p=0.28). In contrast, epidemiological sibling analyses revealed that the siblings of females with ADHD are at higher familial risk of ADHD than siblings of affected males (OR=1.14, [95% CI: 1.11-1.18], p=1.5E-15). Conclusions Overall, this study supports a greater familial burden of risk in females with ADHD and some clinical and etiological heterogeneity, based on epidemiological analyses. However, molecular genetic analyses suggest that autosomal common variants largely do not explain the sex bias in ADHD prevalence.

Published
2018

49. Clinical Characteristics of Inpatients with Childhood vs. Adolescent Anorexia Nervosa

Author

Jaite, Charlotte, primary, Bühren, Katharina, additional, Dahmen, Brigitte, additional, Dempfle, Astrid, additional, Becker, Katja, additional, Correll, Christoph U., additional, Egberts, Karin M., additional, Ehrlich, Stefan, additional, Fleischhaker, Christian, additional, von Gontard, Alexander, additional, Hahn, Freia, additional, Kolar, David, additional, Kaess, Michael, additional, Legenbauer, Tanja, additional, Renner, Tobias J., additional, Schulze, Ulrike, additional, Sinzig, Judith, additional, Thomae, Ellen, additional, Weber, Linda, additional, Wessing, Ida, additional, Antony, Gisela, additional, Hebebrand, Johannes, additional, Föcker, Manuel, additional, and Herpertz-Dahlmann, Beate, additional

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results