1. Determinants of biological drug survival in rheumatoid arthritis: evidence from a Hungarian rheumatology center over 8 years of retrospective data
- Author
-
Brodszky V, Bíró A, Szekanecz Z, Soós B, Baji P, Rencz F, Tóthfalusi L, Gulácsi L, and Péntek M
- Subjects
rheumatoid arthritis ,biologicals ,drug survival ,switch ,registry ,Medicine (General) ,R5-920 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Valentin Brodszky,1 Anikó Bíró,1,2 Zoltán Szekanecz,3 Boglárka Soós,3 Petra Baji,1 Fanni Rencz,1,4 László Tóthfalusi,5 László Gulácsi,1 Márta Péntek1,6 1Department of Health Economics, Corvinus University of Budapest, Budapest, , Hungary; 2School of Economics, The University of Edinburgh, Edinburgh, UK; 3Department of Rheumatology, Institute of Medicine, University of Debrecen Faculty of Medicine, Debrecen, Hungary; 4Semmelweis University Doctoral School of Clinical Medicine, Budapest, Hungary; 5Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary; 6Department of Rheumatology, Flór Ferenc County Hospital, Kistarcsa, Hungary Objective: To compare drug survival of biological therapies in patients with rheumatoid arthritis (RA), and analyze the determinants of discontinuation probabilities and switches to other biological therapies.Materials and methods: Consecutive RA patients initiating first biological treatment in one rheumatology center between 2006 and 2013 were included. Log-rank test was used to analyze the differences between the survival curves of different biological drugs. Cox regression was applied to analyze the discontinuation due to inefficacy, the occurrence of adverse events, or to any reasons.Results: A total of 540 patients were included in the analysis. The most frequently used first-line biological treatments were infliximab (N=176, 33%), adalimumab (N=150, 28%), and etanercept (N=132, 24%). Discontinuation of first tumor necrosis factor-alpha (TNF-α) treatment was observed for 347 (64%) patients, due to inefficacy (n=209, 60%), adverse events (n=103, 30%), and other reasons (n=35, 10%). Drug survival rates for TNF-α and non-TNF-α therapies were significantly different, and were in favor of non-TNF-α therapies. Every additional number of treatment significantly increased the risk of inefficacy by 27% (p
- Published
- 2017