312 results on '"Renauld J"'
Search Results
2. Correction: Interleukin-22-deficiency and microbiota contribute to the exacerbation of Toxoplasma gondii-induced intestinal inflammation
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Couturier-Maillard, A, Froux, N, Piotet-Morin, J, Michaudel, C, Brault, L, Le Bérichel, J, Sénéchal, A, Robinet, P, Chenuet, P, Jejou, S, Dumoutier, L, Renauld, J C, Iovanna, J, Huber, S, Chamaillard, M, Quesniaux, V F J, Sokol, H, and Ryffel, B
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- 2019
- Full Text
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3. Biology of Interleukin 9 and its Receptor
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Renauld, J.-C., Houssiau, F., Vink, A., Uyttenhove, C., Warmer, G., Van Snick, J., Gergely, János, editor, Benczúr, M., editor, Erdei, Anna, editor, Falus, A., editor, Füst, Gy., editor, Medgyesi, G., editor, Petrányi, Gy., editor, and Rajnavölgyi, Éva, editor
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- 1993
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4. IL-22 deficiency in donor T cells attenuates murine acute graft-versus-host disease mortality while sparing the graft-versus-leukemia effect
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Couturier, M, Lamarthée, B, Arbez, J, Renauld, J-C, Bossard, C, Malard, F, Bonnefoy, F, Mohty, M, Perruche, S, Tiberghien, P, Saas, P, and Gaugler, B
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- 2013
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5. Interleukin-22 Deficiency Accelerates the Rejection of Full Major Histocompatibility Complex-Disparate Heart Allografts
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Kapessidou, P., Poulin, L., Dumoutier, L., Goldman, M., Renauld, J.-C., and Braun, M.Y.
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- 2008
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6. JAK kinases overexpression promotes in vitro cell transformation
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Knoops, L, Hornakova, T, Royer, Y, Constantinescu, S N, and Renauld, J-C
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- 2008
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7. IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes
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Dumoutier, L, Van Roost, E, Ameye, G, Michaux, L, and Renauld, J-C
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- 2000
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8. Sputum eosinophilia: an early marker of bronchial response to occupational agents
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Vandenplas, O., DʼAlpaos, V., Heymans, J., Jamart, J., Thimpont, J., Huaux, F., Lison, D., and Renauld, J-C.
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- 2009
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9. Interleukin-9
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RENAULD, J, primary and VANSNICK, J, additional
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- 2003
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10. IL-9 promotes anti-Mycobacterium leprae cytotoxicity: involvement of IFNγ
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Finiasz, M. R., Franco, M. C., de la Barrera, S., Rutitzky, L., Pizzariello, G., del Carmen Sasiain, M., Renauld, J.-C., Van Snick, J., and Fink, S.
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- 2007
11. New insights into the role of cytokines in asthma
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Renauld, J-C
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- 2001
12. Cloning of genes coding for antigens recognized by cytolytic T lymphocytes
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DEPLAEN, E, primary, LURQUIN, C, additional, BRICHARD, V, additional, VANDERBRUGGEN, P, additional, RENAULD, J, additional, COULIE, P, additional, SZIKORA, J, additional, WOLFEL, T, additional, VANPEL, A, additional, and BOON, T, additional
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- 1996
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13. A STUDY ON NEOCORTICAL DEVELOPMENT USING IL-9 TRANSGENIC MOUSE
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ISHII, K., RENAULD, J-C., and UYEMURA, K.
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- 1999
14. Interleukin-9
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Renauld, J.‐C, primary, Houssiau, F., additional, Louahed, J., additional, Vink, A., additional, Snick, J. Van, additional, and Uyttenhove, C., additional
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- 1993
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15. IL-12 inhibits in vitro immunoglobulin production by human lupus peripheral blood mononuclear cells (PBMC)
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Houssiau, F. A., Mascart-Lemone, F., Stevens, M., Libin, M., Devogelaer, J.-P., Goldman, M., and Renauld, J.-C.
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- 1997
16. IL-22-induced antimicrobial peptides are key determinants of mucosal vaccine-induced protection against H. pylori in mice
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Moyat, M, Bouzourene, H, Ouyang, W, Iovanna, J., Renauld, J-C, Velin, D, Moyat, D, Ouyang, D, Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), UNISciences, Genentech, Inc., Genentech, Inc. [San Francisco], Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Ludwig Institute for Cancer Research, and UCL - SSS/DDUV - Institut de Duve
- Subjects
0301 basic medicine ,MESH: Th17 Cells ,Pancreatitis-Associated Proteins ,MESH: Mice, Knockout ,Mice ,0302 clinical medicine ,Immunology and Allergy ,MESH: Animals ,MESH: Proteins ,Helicobacter ,Cells, Cultured ,Mice, Knockout ,Mice, Inbred BALB C ,biology ,MESH: Antimicrobial Cationic Peptides ,Interleukin ,Urease ,MESH: Gene Expression Regulation ,3. Good health ,Bacterial vaccine ,Bacterial Vaccines ,030211 gastroenterology & hepatology ,Female ,Antibody ,MESH: Cells, Cultured ,MESH: Interleukins ,Immunology ,MESH: Urease ,MESH: Mice, Inbred BALB C ,Helicobacter Infections ,03 medical and health sciences ,Antigen ,Immunity ,MESH: Mice, Inbred C57BL ,Animals ,Humans ,MESH: Pancreatitis-Associated Proteins ,MESH: Mice ,Antigens, Bacterial ,Mucous Membrane ,MESH: Humans ,Helicobacter pylori ,Interleukins ,MESH: Helicobacter Infections ,Proteins ,MESH: Mucous Membrane ,biology.organism_classification ,Mice, Inbred C57BL ,Disease Models, Animal ,030104 developmental biology ,Mucosal immunology ,Gene Expression Regulation ,biology.protein ,Th17 Cells ,MESH: Helicobacter pylori ,MESH: Disease Models, Animal ,[SDV.IMM.VAC]Life Sciences [q-bio]/Immunology/Vaccinology ,MESH: Female ,MESH: Antigens, Bacterial ,MESH: Bacterial Vaccines ,Antimicrobial Cationic Peptides - Abstract
International audience; Despite the recent description of the mucosal vaccine-induced reduction of Helicobacter pylori natural infection in a phase 3 clinical trial, the absence of immune correlates of protection slows the final development of the vaccine. In this study, we evaluated the role of interleukin (IL)-22 in mucosal vaccine-induced protection. Gastric IL-22 levels were increased in mice intranasally immunized with urease þ cholera toxin and challenged with H. felis, as compared with controls. Flow cytometry analysis showed that a peak of CD4 þ IL-22 þ IL-17 þ Tcells infiltrating the gastric mucosa occurred in immunized mice in contrast to control mice. The inhibition of the IL-22 biological activity prevented the vaccine-induced reduction of H. pylori infection. Remarkably, anti-microbial peptides (AMPs) extracted from the stomachs of vaccinated mice, but not from the stomachs of non-immunized or immunized mice, injected with anti-IL-22 antibodies efficiently killed H. pylori in vitro. Finally, H. pylori infection in vaccinated RegIIIb-deficient mice was not reduced as efficiently as in wild-type mice. These results demonstrate that IL-22 has a critical role in vaccine-induced protection, by promoting the expression of AMPs, such as RegIIIb, capable of killing Helicobacter. Therefore, it can be concluded that urease-specific memory Th17/Th22 cells could constitute immune correlates of vaccine protection in humans.
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- 2017
17. L'ŒUVRE INACHEVÉE DE MARIO CALDERONI
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Renauld, J.-F.
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- 1918
18. QUELQUES UVRES DE PHILOSOPHIE ITALIENNE
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Renauld, J.-F.
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- 1920
19. NOTE SUR LA THÉORIE DE LA VÉRITÉ ET DE LA CONNAISSANCE DANS LES « PROBLEMS OF PHILOSOPHY » DE M. BERTRAND RUSSELL
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Renauld, J.-F.
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- 1922
20. French Intensive Care Society, International congress - Réanimation 2016
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Jaillette, E, Girault, C, Brunin, G, Zerimech, F, Chiche, A, Broucqsault Dedrie, C, Fayolle, C, Minacori, F, Alves, I, Barrailler, S, Robriquet, L, Delaporte, E, Thellier, D, Delcourte, C, Duhamel, A, Nseir, S, Valette, X, Desmeulles, I, Savary, B, Masson, R, Seguin, A, Daubin, C, Sauneuf, B, Verrier, P, Pottier, V, Orabona, M, Samba, D, Viquesnel, G, Lermuzeaux, M, Hazera, P, Hanouz, J, Parienti, J, Du Cheyron, D, Demoule, A, Clavel, M, Rolland Debord, C, Perbet, S, Terzi, N, Kouatchet, A, Wallet, F, Roze, H, Vargas, F, Guérin, C, Dellamonica, J, Jaber, S, Similowski, T, Quenot, J, Binquet, C, Vinsonneau, C, Barbar, S, Vinault, S, Deckert, V, Lemaire, S, Hssain, A, Bruyère, R, Souweine, B, Lagrost, L, Adrie, C, Jung, B, Daurat, A, De Jong, A, Chanques, G, Mahul, M, Monnin, M, Molinari, N, Lheureux, O, Trepo, E, Hites, M, Cotton, F, Wolff, F, Surin, R, Créteur, J, Vincent, J, Gustot, T, Jacobs, F, Taccone, F, Neuville, M, Timsit, J, El Helali, N, Le Monnier, A, Magalhaes, E, Radjou, A, Smonig, R, Soubirou, J, Voiriot, G, Sonneville, R, Bouadma, L, Mourvillier, B, Gélisse, E, Brasseur, A, Roisin, S, De Backer, D, Van Ruychevelt, V, Carlier, E, Piagnerelli, M, Vanhaeverbeek, M, Danguy, C, Biston, P, Au, S, Begot, E, Dalmay, F, Repessé, X, Prat, G, Bouferrache, K, Slama, M, Vieillard Baron, A, Monnet, X, Marik, P, Teboul, J, Jozwiak, M, Richard, C, Chauvet, J, El Dash, S, Delastre, O, Bouffandeau, B, Jusserand, D, Michot, J, Bauer, F, Brazier, F, Mercado, P, Kontar, L, Titeca, D, De Cagny, B, Bacari Risal, G, Riviere, A, Maizel, J, Guillot, C, Le Reun, C, Lampin, M, Sadik, A, Botte, A, Leteurtre, S, Collins, A, Kempeneers, C, Cajgfinger, N, Ohlmann, C, Pouyau, R, Subtil, F, Baudin, F, Massenavette, B, Javouhey, E, Milesi, C, Essouri, S, Liet, J, Afanetti, M, Durand, S, Durand, P, Roze, J, Dupont, D, Cambonie, G, Soyer, B, Rusca, M, Lukaszewicz, A, Crassard, I, Guichard, J, Bresson, D, de la Garanderie, D, Cantier, M, Sabben, C, Louedec, L, Delbosc, S, Journé, C, Ou, P, Klein, I, Chau, F, Lefort, A, Desilles, J, Michel, J, Mazighi, M, Salem, O, Demeret, S, Bolgert, F, Sharshar, T, Grabli, D, Arib, S, Crippa, I, Soummer, A, Engrand, N, Guedin, P, Aldea, S, Cerf, C, Desailly, V, Pasquier, P, Brun, P, Roux, D, Latournerie, G, Kasprzyk, L, Grosjean, V, Latreche, A, Habert, P, Huot, S, Jobin, T, Tesnière, A, Dreyfuss, D, Ricard, J, Mignon, A, Gaudry, S, Laithier, F, Kimmoun, A, Chouihed, T, Albizzati, S, Camenzind, E, Vanhuyse, F, Levy, B, Cour, M, Venet, F, Hernu, R, Demaret, J, Monneret, G, Argaud, L, Dumas, F, Lamhaut, L, Rosencher, J, Pène, F, Varenne, O, Carli, P, Jouven, X, Spaulding, C, Cariou, A, Geri, G, Bonnetain, F, Marijon, E, Empana, J, Mirouse, A, Resche Rigon, M, Mayaux, J, Rabbat, A, Meert, A, Benoit, D, Bruneel, F, Azoulay, E, Dupuis, C, Schwebel, C, Ruckly, S, Goldgran Toledano, D, Marcotte, G, Lafarge, A, Pichereau, C, Theodose, I, Scotto, M, Kemlin, D, Ghrenassia, E, Schlemmer, B, Vimpere, D, Galicier, L, Contou, D, Guérot, E, Grimaldi, D, Ricome, S, Maury, E, Plantefève, G, Dessap, A, Brun Buisson, C, de Prost, N, Dubé, B, Delemazure, J, Dres, M, Rousseau, L, Drouot, X, Diaz, V, Rebollar, Y, Frat, J, Thille, A, Aissa, D, Coquet, P, Ruiz, J, Ferre, F, Hoarau, L, Riu Poulenc, B, Bataille, B, Silva, S, Baudel, J, Bigé, N, Tahiri, J, Dubée, V, Guidet, B, Ait Oufella, H, Jinglun, L, Shen, F, Bailly, S, Leroy, O, Montravers, P, Constantin, J, Dupont, H, Guillemot, D, Lortholary, O, Perrigault, P, Gangneux, J, Razazi, K, Mekontso Dessap, A, Jansen, C, Lecronier, M, Sandrine, V, Mira, J, Blein, S, Marin, N, Rousseau, C, Charpentier, J, Pachot, A, Hraiech, S, Bordes, J, De, L, Mège, J, Forel, J, Guervilly, C, Adda, M, Raoult, D, Papazian, L, Kentish Barnes, N, Cohen Solal, Z, Souppart, V, Kerhuel, L, Haubertin, C, Exbrayat, I, Rozières, E, Argain, A, Suc, A, Vignes, M, Cougot, P, Fourcade, O, Brunel, E, Messika, J, Tubach, F, Dubief, E, Pasquet, B, Guillo, S, Pierron, C, Grimaud, M, Farnoux, C, Maillard, A, Decavèle, M, Prodanovic, H, Idbaih, A, Alentorn, A, Delattre, J, De Montmollin, E, Brule, N, Conrad, M, Dailler, F, Navellou, J, Alves, M, Tonnelier, J, Picard, G, Rogemond, V, Honnorat, J, Marzorati, C, Lebert, C, Perez, P, Citerio, G, Legriel, S, Tripon, S, Mallet, M, Rudler, M, Imbert Bismut, F, Thabut, D, Canet, E, Faguer, S, Moreau, A, Barbier, F, Merceron, S, Guitton, C, Labadie, F, Lemiale, V, Faucher, E, Klouche, K, Chevret, S, Ragot, S, Coudroy, R, Boulain, T, Jamet, A, Mercat, A, Brochard, L, Roux, A, Franchineau, G, Brechot, N, Lebreton, G, Hekimian, G, Nieszkowska, A, Leprince, P, Trouillet, J, Combes, A, Schmidt, M, Barrot, L, Piton, G, Bailey, M, Panwar, R, Belin, N, Belon, F, Patry, C, Grandperrin, M, Chaignat, C, Labro, G, Vivet, B, Capellier, G, Daix, T, Guérin, E, Tavernier, E, Mercier, E, Gissot, V, Vallejo, C, François, B, Ravry, C, Pichon, N, Chapellas, C, Fedou, A, Galy, A, Ploy, M, Barraud, O, Vignon, P, Thooft, A, Conotte, R, Colet, J, Le Dorze, M, Tarazona, V, Brumpt, C, Moins Teisserenc, H, Uhel, F, Azzaoui, I, Gregoire, M, Pangault, C, Dulong, J, Cynober, L, Roussel, M, Le Tulzo, Y, Tarte, K, Demiselle, J, Auchabie, J, Dequin, P, Chudeau, N, Fourrier, F, Grange, S, Piquilloud, L, Lautrette, A, Boyer, S, Letheulle, J, Lerolle, N, Truche, A, Clec'H, C, Zaoui, P, Laurent, V, Toledano, D, Ragey, S, Gros, A, Dumenil, A, Jamali, S, Darmon, M, Chouraqui, M, Dewitte, A, Chastel, B, Carles, P, Fleureau, C, Joannes Boyau, O, Ouattara, A, Joseph, A, Garrouste Orgeas, M, Max, A, Lerin, T, Grégoire, C, Kloeckner, M, Bruel, C, Brochon, S, Philippart, F, Pichot, E, Simons, C, Flint, A, Aubron, C, Bellomo, R, Pilcher, D, Cheng, A, Hegarty, C, Martinelli, A, Howden, B, Reade, M, Mcquilten, Z, Bretonnière, C, Villers, D, Soares, M, Gonzalez, F, Vincent, F, Fauché, C, Gay, S, Skowron, O, Levrat, A, Dorez, D, Foucrier, A, Pease, S, Gauss, T, Paugam, C, Gorham, J, Ameye, L, Paesmans, M, Berghmans, T, Sculier, J, Deras, P, Martinez, O, Latry, P, Capdevila, X, Charbit, J, Jaubert, J, Etiennar, C, Ginoux, L, Sebbah, J, Haouache, H, Dhonneur, G, Cheikh, C, Moussaid, I, Ghazaoui, O, Belkadi, K, El Youssoufi, S, Salmi, S, Pajot, L, Zuber, B, Bedos, J, Dupont, B, Eugène, A, Galateau Sallé, F, Michard, B, Lebas, B, Boivin, A, Guillot, M, Harlay, M, Janssen Langenstein, R, Schenck, M, Ellero, B, Woehl Jaegle, M, Besch, C, Castelain, V, Bachellier, P, Schneider, F, Camus, C, Saliba, F, Goubaux, B, Bonadona, A, Lavayssiere, L, Quinart, A, Barbot, O, Dharancy, S, Delafosse, B, Barraud, H, Galbois, A, Veber, B, Cayot, S, Souche, B, Locher, C, Roux, O, Figorilli, F, Putignano, A, Houssel, P, Francoz, C, Weiss, E, Agarwal, B, Jalan, R, Durand, F, Ghezala, H, Daoudi, R, Kaddour, M, Ghadhoune, H, Rachedi, E, Guissouma, J, Ben Slimene, A, Azzeza, W, Brahmi, H, Elghord, H, Kada, A, Chikh, R, Slimani, R, A. Bouyoucef, K, Regaieg, K, Kamilia, C, Baccouche, N, Turki, O, Chaari, A, Ben, H, Bouaziz, M, Medhioub, F, Zekri, M, Rgieg, K, Bhimada, C, Mounir, B, Lang, E, Welschbillig, S, Perrin, M, Devys, J, Benbernou, S, Mokhtari Djebli, H, Ilies, S, Bouyacoub, K, Azza, A, Zogheib, E, Nader, J, Villeret, L, Guilbart, M, Besserve, P, Caus, T, Mastroianni, C, Santi, F, Hékimian, G, Pascal, L, Chastre, J, Perrier, V, Deniau, B, Klasen, F, Ponthus, J, Ngasseu, P, Amilien, V, Barsam, E, Lehericey, P, Tchir, M, Georger, J, Puech, B, Vandroux, D, Roussiaux, A, Belcour, D, Ferdynus, C, Martinet, O, Jabot, J, Fresco, M, Demeilliers Pfister, G, Merle, V, Brunel, V, Dureuil, B, Leydier, S, Clerc Urmes, I, Lemarie, J, Maigrat, C, Cravoisy Popovic, A, Barraud, D, Nace, L, Gibot, S, Agrinier, N, Bollaert, P, Daban, J, Boutonnet, M, Dumas, G, Falzone, E, Jault, P, Lenoir, B, Makunza, J, Mejeni, N, Mazaud, A, Béague, S, Rousselle, A, Durocher, A, Grinea, A, Bedoui, N, Stoian, A, Baboi, L, Gobert, F, Yonis, H, Tapponier, R, Bruyneel, A, Bonus, T, Cuvelier, G, Machayeckhi, S, Olieuz, S, Legrand, A, Feki, F, Jamoussi, A, Merhebene, T, Braham, E, Ghariani, A, Mezni, F, Slim, L, Khelil, J, Besbes, M, Marchalot, A, Beduneau, G, Carpentier, D, Besnier, E, Gastaldi, G, Abily, J, Beuzelin, M, Nay, M, Mankikian, J, Hervé, V, Soulie, M, Cronier, P, Kantor, E, Federici, L, Gilbert, M, Mezhari, I, Choukroun, G, Marque, S, Coppere, Z, Fulgencio, J, Blayau, C, Pham, T, Djibre, M, Reffienna, M, Lefort, S, Debue, A, Daviaud, F, Cabon, S, Addou, Z, Douah, A, Moussati, M, Belhabiche, K, Aouffen, N, Soulier, S, Mauriat, P, Tafer, N, Mortamet, G, Amaddeo, A, Khirani, S, Fauroux, B, Khanes, G, Liutko, O, Bidnenko, S, Doye, E, Voirin, N, Maucort Boulch, D, Kolev Descamp, K, Aouane, I, Essid, A, Hammami, W, Haegy, I, Bataille, J, Bergounioux, J, Morin, L, Ray, S, Maclaren, G, Nadel, S, Kneyber, M, Peters, M, Jansen, K, De Luca, D, Wilson, C, Schlapbach, L, Tissières, P, Girard, A, Savajols, E, Burguet, A, Semama, D, Litzler Renault, S, Fredj, H, Hassouna, M, Hechmi, Y, Cherif, M, Zouheir, J, Dernane, A, Bouakkaz, F, Taleb, L, Zeddine Mouhsen, A, Lyazidi, A, Richard, J, Mouhsen, A, Harmouchi, M, Rattal, M, Huck, M, Leclerc, T, Donat, N, Cirodde, A, Schaal, J, Masson, Y, Hoffmann, C, Cerland, L, Valentino, R, Chabartier, C, Villain Coquet, L, Ferge, J, Brouste, Y, Mehdaoui, H, Louriz, M, Madani, N, Amlaiky, F, Dendane, T, Abidi, K, Zekraoui, A, Zeggwagh, A, Abouqal, R, Brahim, A, Ferhi, F, Bouslama, M, Benjazia, K, Zeineb, A, Mahassen, D, Cadiet, J, Ferron, M, Prat, V, Erraud, A, Aillerie, V, Mevel, M, Grabherr, A, Chatham, J, Gauthier, C, Lauzier, B, Rozec, B, Joffre, J, Loyer, X, Lavillegrand, J, Zeboudj, L, Laurans, L, Esposito, B, Tedgui, A, Mallat, Z, Wei, C, Kattani, N, Louis, H, Orlowski, S, Tharaux, P, Burban, M, Meyer, G, Olland, A, Yver, B, Toti, F, Schini Kerth, V, Monnier, A, Leborgne, P, Meziani, F, Clavier, T, Paulus, M, Castel, H, Richard, V, Pons, S, Skurnik, D, Six, S, Jaffal, K, 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Faucher, M, Mokart, D, la Mourtada, L, Virgnie, L, Gaudet, A, Parmentier Decrucq, E, De Freitas Caires, N, Dubucquoi, S, Lassalle, P, Mathieu, D, Tapponnier, R, Quintin, L, Pichot, C, Petitjeans, F, Guillon, A, Jouan, Y, Breah, D, Gueugnon, F, Dalloneau, E, Baranek, T, Henry, C, Morello, E, Renauld, J, Pichavant, M, Gosset, P, Courty, Y, Diot, P, Si Tahar, M, Tadié, J, Vuillard, C, La Combe, B, Ponsin, P, Boddaert, G, Grand, B, Baudoin, Y, Bonnet, S, Snouda, S, Abbes, M, Benchiekh, I, Sedghiani, I, Maaroufi, N, Belayachi, J, Debono, L, Auvet, A, Nadal Desbarats, L, Tankovic, J, Dahoumane, R, Oufella, H, Offenstadt, G, Filali, A, Faure, E, Van Grunderbeeck, N, Nigeon, O, Bazus, H, Mallat, J, Thevenin, D, Lempereur Legros, S, Ledoux, D, Nys, M, Clermont, O, Aubry, A, Fernandes, R, Venot, M, Garnaud, C, Cornet, M, Pavese, P, Foroni, L, Boisset, S, le Maubon, D, Abid, M, Ezzouine, H, Edith, C, Sztrymf, B, Brunot, V, Serre, J, Landreau, L, Jean Michel, V, Couturaud, F, Moore, E, Egreteau, P, Boles, J, Herbrecht, J, Kaeuffer, C, Meyer, A, Arfi, K, Lesage, F, Séguret, S, Dupic, L, De Saint Blanquat, L, Baptiste, A, Georges, H, Delannoy, P, Devos, P, Albarracin, D, Ducousso Lacaze, A, Dufour, J, Cabasson, S, Veinstein, A, Chatellier, D, Robert, R, Ha, V, Lau, N, Mimoun, L, Forceville, X, Maamar, A, Chevalier, S, Botoc, V, Rouleau, S, Desachy, A, Calvat, S, Lafon, C, Cracco, C, Temime, J, Molmy, P, Gasan, G, Béranger, A, Chappuy, H, Bertrand, P, Beurton, A, Bodet Contentin, L, Danin, P, Dubois, E, Karaca, Y, Mora, P, Vodovar, D, Desbrosses, Y, Chauchet, A, Daguindau, E, Deconinck, E, Chermak, A, Baron, M, Calvet, L, Sapin, A, Pereira, B, Vettoretti, L, Lacroix, J, Clayton, L, Sabri, E, Bardiaux, L, Tiberghien, P, Hebert, P, Lengliné, E, Socié, G, Borcoman, E, Rusinova, K, Del Galy, A, Mercier, M, Hamel, J, Raveau, T, Moles, M, Clavert, A, Hunault Berger, M, Ifrah, N, Schmidt Tanguy, A, Carreira, S, Lavault, S, Pallanca, O, Morawiec, E, Arnulf, I, D'Humières, T, Carrié, C, Gisbert Mora, C, Bonnardel, E, Biais, M, Hilbert, G, Joannon, T, Marincamp, A, Chiche, J, Ferre, A, Lichtenstein, D, Meziere, G, Gonzalez, C, Hamzaoui, O, Geffriaud, T, Leleu, F, Boissier, F, Cuquemelle, E, Lim, P, Amara, R, Léger, J, Jacob, C, Bouferache, K, Ragot, C, Corradi, L, Maurice, L, Julliand, S, Deho, A, Le Bourgeois, F, Jacquot, A, Valla, F, Letois, F, Salvadori, A, Ottonello, G, Blanot, S, Montmayeur, J, Orliaguet, G, Tarmiz, K, Habas, F, Baleine, J, Lebouhellec, J, Combes, C, Chomton, M, Jouvet, P, Ranchin, B, Macher, M, Gaillot, T, Moine, M, Ageron, F, Jannel, C, Debillon, T, Wroblewski, I, Duprey, M, Jarlier, V, Luyt, C, Longval, T, Schnell, D, Padoin, C, Cohen, Y, Gaies, E, Triki, S, Klouz, A, Moussa, M, Desrumaux, F, May, F, Nguyen, J, Tiercelet, K, Fournier, J, Cherin, M, Kitzis, M, Misset, B, Mathien, C, Poidevin, A, Donatti, L, Mootien, J, Pinto, L, Egard, M, Bodur, G, Barberet, G, Ionescu, C, Ganster, F, Guiot, P, Kuteifan, K, Mpela, A, Chelly, J, Guérin, L, Persichini, R, Hullin, T, Deye, N, Aubertein, P, Paul, M, Bougouin, W, Sandroni, C, Passouant, O, Llitjos, J, Chenevier Gobeaux, C, Batteux, F, Drouet, L, Voicu, S, Henry, P, Dillinger, J, Resiere, D, Dessoy, A, Faivre, V, Damoisel, C, Stiel, L, Galoisy, A, Mauvieux, L, Zobairi, F, Angles Cano, E, Piau, C, Jeannet, R, Feuillard, J, Jolly, L, Boufenzer, A, Carrasco, K, Derive, M, Merdji, H, Belaidouni, N, Toubiana, J, L'Hermitte, Y, Woimant, F, Oppenheim, C, Couvreur, C, Dolveck, F, Devriese, M, Dupeyrat, S, Ray, P, Lefevre, G, Fartoukh, M, Roothaer, N, Carpentier, A, Vaniet, F, Maisonneuve, A, Wiel, E, Canu, S, Hammad, E, Antonini, F, Poirier, M, Vigne, C, Haddam, M, Alingrin, J, Dangers, L, Mangiapan, G, Huet, I, Dhalluin, X, Bautin, N, Quiot, J, De Vecchi, C, Chenivesse, C, Smaoui, M, El Alami, E, Weiss, N, Mochel, F, Galanaud, D, Puybasset, L, Lodey, M, Guiller, E, Vuillaume, C, De Pasquale, F, Demonet, J, Sinnah, F, Dalloz, M, D'Ortho, M, Rouvel Tallec, A, Couret, D, Catan, A, Nativel, B, Planesse, C, Diotel, N, Meilhac, O, Roy Gash, F, Lebard, C, Larbi, A, Gaudin, V, Bonnin, F, Sultan, O, Hoc, C, Mathieu, E, Lapergue, B, Bourdain, F, Caron, M, Parrot, A, Labbe, V, Hafiani, E, Quesnel, C, Genay, S, Décaudin, B, Ethgen, S, Odou, P, Lebuffe, G, Mcquilte, Z, Allaouchiche, B, Verdière, B, Nyunga, M, Banaias, N, Colling, D, Kauv, M, Blondeau, E, Auclin, E, Haw Berlemont, C, Taieb, J, Oudard, S, Morissette, G, Kechaou, W, Litalien, C, Merouani, A, Phan, V, Bouchard, J, Starck, J, Briand, N, Sachs, P, Angoulvant, F, Sommet, J, Holvoet, L, Benkerrou, M, Dreyfus, L, Bordet, F, Touzet, S, Denis, A, Le Coz, J, Chéron, G, Nabbout, R, Patteau, G, Heilbronner, C, Hubert, P, Oualha, M, Crulli, B, Toledano, B, Poirier, N, Vobecky, S, Khouadja, H, Vinet, M, Vinclair, C, Beloncle, F, Radermacher, P, Asfar, P, Coupez, E, Bohé, J, Shinotsuka, C, Caironi, P, Villois, P, Fontana, V, Creteur, J, Pourcine, F, Vong, L, Weyer, C, Akando, B, Abdallah, R, Wetzstein, M, Antier, N, Serroukh, Y, Boudjeltia, K, Joosten, A, Rousseau, A, Delabranche, X, Grunebaum, L, Mootien, Y, Gaci, R, Garric, J, Delbove, A, Darreau, C, Dargent, A, Soudry Faure, A, De Chambrun, M, Demondion, P, Blanchard, J, Chocron, S, Meneveau, N, Corsi, F, Meynieu, P, Repusseau, B, Germain, A, Baudry, G, Hierle, L, Besch, G, Thomas, G, Cassir, N, Dizier, S, Roch, A, Trebbia, G, Govindaradjou, K, Devaquet, J, Picard, C, Parquin, F, Leguen, M, Felten, M, Sage, E, Chapelier, A, Duruisseaux, M, Fleury, J, Antoine, M, Carette, M, Wislez, M, Givel, C, De Margerie Mellon, C, De Kerviler, E, Tandjaoui Lambiotte, Y, Freynet, O, Baux, E, Das, V, Talec, P, Anguel, N, Louis, G, Girerd, N, Tallon, P, Hadchouel Duvergé, A, Salvi, N, Cairet, P, Delacourt, C, Blandine, B, Beraud, L, Lamaziere, A, Lionnet, F, Lehingue, S, D'Journo, X, Jean Marie, F, Thibault, R, Makhlouf, A, Mulliez, A, Dadet, S, Kekstas, G, Preiser, J, Rotovnik, K, Rozalen, I, Kupczyk, K, Krznaric, Z, Cano, N, Pichard, C, Le Roux, B, Jotterand, C, Rooze, S, Moullet, C, Henin, A, Ettori, F, Zemmour, C, Boher, J, Feltry, A, Ben, S, Audibert, J, Conia, A, Gontier, O, Hamrouni, M, Lherm, T, Ouchenir, A, Rétif, J, Proudhom, A, Lagardere, C, Tissot, S, Kalfon, P, Sacre, L, Villa, A, Khadija, A, Garnier, R, Vasset, B, Heinzelman, A, Jouffroy, R, Durand, E, Compagnon, P, Jebri, A, Legout, C, Castot Villepelet, A, Valade, S, Lesieur, O, Delmas, B, Visseaux, B, Cohen, J, Nguyen, L, Morbieu, C, Burdet, C, Lescure, F, Armand Lefevre, L, Yazdanpanah, Y, Houhou Fidouh, N, Cazaux, M, Goff Jérôme, L, Meignin, V, Boutboul, D, Rispail, P, Besnard, N, Ceballos, P, Stoclin, A, Rotolo, F, Wartelle, M, Hicheri, Y, Maillet, S, Chachaty, E, Pignon, J, Bialais, E, Julie, D, Paoloni, L, Wittebolle, X, Hickmann, C, Castanares Zapatero, D, Tordeur, A, Colmant, L, Wittebole, X, Tirone, G, Laterre, P, Ducroux, L, Kemlin, C, Moulton, E, Rosso, C, Le Neindre, A, Mongodi, S, Bouhemad, B, Rodrigues, J, Botteau, C, Waroquier, F, Christiaens, K, Vantrimpont, F, Elkhawand, C, Vermeesh, F, Vermeesh, F., and CITERIO, GIUSEPPE
- Abstract
Determinants of outcome in critically ill patients with hematological malignancy and central neurological failure: data from the TRIAL OH study
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- 2016
21. Complementarity and redundancy of IL-22-producing innate lymphoid cells
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Rankin, LC, Girard-Madoux, MJH, Seillet, C, Mielke, LA, Kerdiles, Y, Fenis, A, Wieduwild, E, Putoczki, T, Mondot, S, Lantz, O, Demon, D, Papenfuss, AT, Smyth, GK, Lamkanfi, M, Carotta, S, Renauld, J-C, Shi, W, Carpentier, S, Soos, T, Arendt, C, Ugolini, S, Huntington, ND, Bez, GT, Vivier, E, Rankin, LC, Girard-Madoux, MJH, Seillet, C, Mielke, LA, Kerdiles, Y, Fenis, A, Wieduwild, E, Putoczki, T, Mondot, S, Lantz, O, Demon, D, Papenfuss, AT, Smyth, GK, Lamkanfi, M, Carotta, S, Renauld, J-C, Shi, W, Carpentier, S, Soos, T, Arendt, C, Ugolini, S, Huntington, ND, Bez, GT, and Vivier, E
- Abstract
Intestinal T cells and group 3 innate lymphoid cells (ILC3 cells) control the composition of the microbiota and gut immune responses. Within the gut, ILC3 subsets coexist that either express or lack the natural cytoxicity receptor (NCR) NKp46. We identified here the transcriptional signature associated with the transcription factor T-bet-dependent differentiation of NCR(-) ILC3 cells into NCR(+) ILC3 cells. Contrary to the prevailing view, we found by conditional deletion of the key ILC3 genes Stat3, Il22, Tbx21 and Mcl1 that NCR(+) ILC3 cells were redundant for the control of mouse colonic infection with Citrobacter rodentium in the presence of T cells. However, NCR(+) ILC3 cells were essential for cecal homeostasis. Our data show that interplay between intestinal ILC3 cells and adaptive lymphocytes results in robust complementary failsafe mechanisms that ensure gut homeostasis.
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- 2016
22. Le principe de proportionnalité, langage commun des cours constitutionnelles
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A. Alen, J. Spreutels, L. Lavrysen, P. Nihoul, E. Peremans, B. Renauld, J. Theunis, W. Verrijdt, Cartabia, M, CARTABIA, MARTA MARIA CARLA, A. Alen, J. Spreutels, L. Lavrysen, P. Nihoul, E. Peremans, B. Renauld, J. Theunis, W. Verrijdt, Cartabia, M, and CARTABIA, MARTA MARIA CARLA
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- 2016
23. Interleukin-22 regulates antimicrobial peptide expression and keratinocyte differentiation to control Staphylococcus aureus colonization of the nasal mucosa
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Mulcahy, M.E., primary, Leech, J.M., additional, Renauld, J-C, additional, Mills, K HG, additional, and McLoughlin, R.M., additional
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- 2016
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24. Donor interleukin-22 and host type I interferon signaling pathway participate in intestinal graft-versus-host disease via STAT1 activation and CXCL10
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Lamarthée, B, primary, Malard, F, additional, Gamonet, C, additional, Bossard, C, additional, Couturier, M, additional, Renauld, J-C, additional, Mohty, M, additional, Saas, P, additional, and Gaugler, B, additional
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- 2016
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25. IL-22BP is produced by eosinophils in human gut and blocks IL-22 protective actions during colitis
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Martin, J C, primary, Bériou, G, additional, Heslan, M, additional, Bossard, C, additional, Jarry, A, additional, Abidi, A, additional, Hulin, P, additional, Ménoret, S, additional, Thinard, R, additional, Anegon, I, additional, Jacqueline, C, additional, Lardeux, B, additional, Halary, F, additional, Renauld, J-C, additional, Bourreille, A, additional, and Josien, R, additional
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- 2016
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- View/download PDF
26. Differential activity of dexamethasone on IL-2-, IL-4-, or IL-9-induced proliferation of murine factor-dependent T cell lines
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Louahed, J., Renauld, J. -C, Jean-Baptiste Demoulin, Baughman, G., Bourgeois, S., Sugamura, K., and Snick, J.
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Immunology ,Immunology and Allergy - Abstract
Mouse helper T cell lines were developed that proliferate permanently without Ag and APCs in response to either IL-2, IL-4, or IL-9, three cytokines whose receptors interact with the IL-2R gamma-chain for signal transduction. Depending on the growth factor, a marked difference was observed regarding the ability of dexamethasone (DEX) to inhibit cell proliferation. In three different cell lines, proliferation induced by IL-2 was completely arrested, while that supported by IL-9 was hardly affected. With IL-4, proliferation was also maintained but less markedly than with IL-9. Although DEX was able to induce apoptosis in these cells, the inhibition of IL-2-induced proliferation was not the result of apoptosis, as this process was equally antagonized by all three factors. Moreover, addition of IL-4 or IL-9 to cultures previously incubated with IL-2 and DEX for several days restored cell proliferation. Finally, autonomous cell variants derived from the factor-dependent cell lines were still protected by IL-4 and IL-9 against growth inhibition by DEX. Together, these results indicate that growth stimulation in the presence of glucocorticoids and inhibition of apoptosis involve distinct aspects of cytokine activities.
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- 1996
27. JAK kinase targeting in hematologic malignancies: a sinuous pathway from identification of genetic alterations towards clinical indications
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Springuel, L., primary, Renauld, J.-C., additional, and Knoops, L., additional
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- 2015
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28. Tumor Necrosis Factor Receptor Signaling in Keratinocytes Triggers Interleukin-24-Dependent Psoriasis-like Skin Inflammation in Mice
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Kumari, S., Bonnet, M. C., Ulvmar, Maria Helena, Wolk, K., Karagianni, N., Witte, E., Uthoff-Hachenberg, C., Renauld, J.-C., Kollias, G., Toftgard, R., Sabat, R., Pasparakis, M., Haase, I., Kumari, S., Bonnet, M. C., Ulvmar, Maria Helena, Wolk, K., Karagianni, N., Witte, E., Uthoff-Hachenberg, C., Renauld, J.-C., Kollias, G., Toftgard, R., Sabat, R., Pasparakis, M., and Haase, I.
- Abstract
Psoriasis is a common chronic inflammatory skin disease with a prevalence of about 2% in the Caucasian population. Tumor necrosis factor (TNF) plays an essential role in the pathogenesis of psoriasis, but its mechanism of action remains poorly understood. Here we report that the development of psoriasis-like skin inflammation in mice with epidermis-specific inhibition of the transcription factor NF-κB was triggered by TNF receptor 1 (TNFR1)-dependent upregulation of interleukin-24 (IL-24) and activation of signal transducer and activator of transcription 3 (STAT3) signaling in keratinocytes. IL-24 was strongly expressed in human psoriatic epidermis, and pharmacological inhibition of NF-κB increased IL-24 expression in TNF-stimulated human primary keratinocytes, suggesting that this mechanism is relevant for human psoriasis. Therefore, our results expand current views on psoriasis pathogenesis by revealing a new keratinocyte-intrinsic mechanism that links TNFR1, NF-κB, ERK, IL-24, IL-22R1, and STAT3 signaling to disease initiation.
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- 2013
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29. La signalisation par le TNFR1 dans les kératinocytes déficients pour NF-κB induit une inflammation cutanée psoriasiforme dépendante de l’IL-24 chez la souris
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Bonnet, M.C., primary, Kumari, S., additional, Ulvmar, M.H., additional, Wolk, K., additional, Karagianni, N., additional, Witte, E., additional, Uthoff-Hachenberg, C., additional, Renauld, J.-C., additional, Kollias, G., additional, Toftgard, R., additional, Sabat, R., additional, Pasparakis, M., additional, and Haase, I., additional
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- 2013
- Full Text
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30. IL-22 is produced by innate lymphoid cells and limits inflammation in allergic airway disease
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Taube, C, Tertilt, C, Gyülveszi, G, Dehzad, N, Kreymborg, K, Schneeweiss, K, Michel, E, Reuter, S, Renauld, J C, Arnold-Schild, D, Schild, H, Buhl, R, Becher, B; https://orcid.org/0000-0002-1541-7867, Taube, C, Tertilt, C, Gyülveszi, G, Dehzad, N, Kreymborg, K, Schneeweiss, K, Michel, E, Reuter, S, Renauld, J C, Arnold-Schild, D, Schild, H, Buhl, R, and Becher, B; https://orcid.org/0000-0002-1541-7867
- Abstract
Interleukin (IL)-22 is an effector cytokine, which acts primarily on epithelial cells in the skin, gut, liver and lung. Both pro- and anti-inflammatory properties have been reported for IL-22 depending on the tissue and disease model. In a murine model of allergic airway inflammation, we found that IL-22 is predominantly produced by innate lymphoid cells in the inflamed lungs, rather than TH cells. To determine the impact of IL-22 on airway inflammation, we used allergen-sensitized IL-22-deficient mice and found that they suffer from significantly higher airway hyperreactivity upon airway challenge. IL-22-deficiency led to increased eosinophil infiltration lymphocyte invasion and production of CCL17 (TARC), IL-5 and IL-13 in the lung. Mice treated with IL-22 before antigen challenge displayed reduced expression of CCL17 and IL-13 and significant amelioration of airway constriction and inflammation. We conclude that innate IL-22 limits airway inflammation, tissue damage and clinical decline in allergic lung disease.
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- 2011
31. Duration of STAT5 activation influences the response of interleukin-2 receptor alpha gene to different cytokines
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VERONIQUE IMBERT, Reichenbach, P., Renauld, J. C., and UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
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Lymphoma ,Hybrid Cells ,Transfection ,Mice ,hemic and lymphatic diseases ,Receptors, Erythropoietin ,STAT5 Transcription Factor ,Animals ,IL-2Ralpha ,Erythropoietin ,STAT5 ,Receptors, Interleukin-9 ,Interleukin-9 ,Receptors, Interleukin-2 ,Receptors, Interleukin ,Thymus Neoplasms ,Milk Proteins ,Recombinant Proteins ,Rats ,DNA-Binding Proteins ,Enzyme Activation ,Gene Expression Regulation ,Trans-Activators ,Cytokines ,Interleukin-2 ,Vanadates ,T-Lymphocytes, Cytotoxic - Abstract
Cytokines and growth factors regulate expression of their target genes via the Janus kinase (Jak)/signal transducers and activators of transcription (STAT) signaling pathway. One of the best characterized targets of STAT is the interleukin-2 receptor-alpha (IL-2Ralpha) gene. Its transcription is controlled by interleukin 2 (IL-2) through STAT5 activation. Using the PC60 cell line, in which the role of STAT5 in the regulation of the murine IL-2Ralpha gene by IL-2 has been elucidated, we have compared the response of this gene to IL-2, interleukin-9 (IL-9) and erythropoietin (Epo). IL-2 and IL-9, but not Epo, stimulate cell surface expression of IL-2Ralpha. This correlates with the fact that IL-2 and IL-9 support long-term STAT5 activation whereas Epo only induces transient activation. In cells treated with vanadate, a protein tyrosine phosphatase (PTP) inhibitor, Epo induces prolonged STAT5 activation and strongly stimulates IL-2Ralpha expression. Our study suggests that by controlling the duration of the STAT activation signal, PTP influences the specificity of cytokine signaling.
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- 1999
32. Interleukin-22 deficiency accelerates the rejection of full major histocompatibility complex-disparate heart allografts.
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Kapessidou, Panayota, Poulin, Lionel, Dumoutier, L, Goldman, Michel, Renauld, J-C, Braun, Michel Y, Kapessidou, Panayota, Poulin, Lionel, Dumoutier, L, Goldman, Michel, Renauld, J-C, and Braun, Michel Y
- Abstract
Interleukin-22 (IL-22) was recently described as an effector cytokine produced by TH17 CD4(+) T lymphocytes that, cooperatively with IL-17, mediates IL-23-driven inflammation. Because there was experimental evidence for the role of IL-17 in acute rejection of vascularized allografts, we undertook the present study to assess the function of IL-22 in the process. There was an early transient expression of IL-22 in C57BL/6 mouse cardiac allografts (2-4 days posttransplantation) transplanted to BALB/c recipients. The main source of IL-22 among infiltrating leukocytes was cells expressing the macrophage/monocyte markers Mac3 and CD11b. T cells and granulocytes present in the rejected graft did not express IL-22. Surprisingly, the absence of IL-22 accelerated the rejection of fully histoincompatible hearts. Histology of rejected organs revealed the presence of intensive intragraft thrombosis and disseminated hemorrhagic necrosis. Taken together, these results demonstrated that IL-22 was not an effector lymphokine in cardiac allograft rejection, but early intragraft expression of the cytokine protected it from rejection., Journal Article, Research Support, Non-U.S. Gov't, info:eu-repo/semantics/published
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- 2008
33. Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia
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Flex, E, Petrangeli, V, Stella, L, Chiaretti, S, Hornakova, T, Knoops, L, Ariola, C, Fodale, V, Clappier, E, Paoloni, F, Martinelli, S, Fragale, A, Sanchez, M, Tavolaro, S, Messina, M, Cazzaniga, G, Camera, A, Pizzolo, G, Tornesello, A, Vignetti, M, Battistini, A, Cavé, H, Gelb, B, Renauld, J, Biondi, A, Constantinescu, S, Foà, R, Tartaglia, M, Gelb, BD, Constantinescu, SN, Tartaglia, M., BIONDI, ANDREA, Flex, E, Petrangeli, V, Stella, L, Chiaretti, S, Hornakova, T, Knoops, L, Ariola, C, Fodale, V, Clappier, E, Paoloni, F, Martinelli, S, Fragale, A, Sanchez, M, Tavolaro, S, Messina, M, Cazzaniga, G, Camera, A, Pizzolo, G, Tornesello, A, Vignetti, M, Battistini, A, Cavé, H, Gelb, B, Renauld, J, Biondi, A, Constantinescu, S, Foà, R, Tartaglia, M, Gelb, BD, Constantinescu, SN, Tartaglia, M., and BIONDI, ANDREA
- Abstract
Aberrant signal transduction contributes substantially to leukemogenesis. The Janus kinase 1 (JAK1) gene encodes a cytoplasmic tyrosine kinase that noncovalently associates with a variety of cytokine receptors and plays a nonredundant role in lymphoid cell precursor proliferation, survival, and differentiation. We report that somatic mutations in JAK1 occur in individuals with acute lymphoblastic leukemia (ALL). JAK1 mutations were more prevalent among adult subjects with the T cell precursor ALL, where they accounted for 18% of cases, and were associated with advanced age at diagnosis, poor response to therapy, and overall prognosis. All mutations were missense, and some were predicted to destabilize interdomain interactions controlling the activity of the kinase. Three mutations that were studied promoted JAK1 gain of function and conferred interleukin (IL)-3-independent growth in Ba/F3 cells and/or IL-9-independent resistance to dexamethasone-induced apoptosis in T cell lymphoma BW5147 cells. Such effects were associated with variably enhanced activation of multiple downstream signaling pathways. Leukemic cells with mutated JAK1 alleles shared a gene expression signature characterized by transcriptional up-regulation of genes positively controlled by JAK signaling. Our findings implicate dysregulated JAK1 function in ALL, particularly of T cell origin, and point to this kinase as a target for the development of novel antileukemic drugs.
- Published
- 2008
34. IL-22-induced antimicrobial peptides are key determinants of mucosal vaccine-induced protection against H. pyloriin mice
- Author
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Moyat, M., Bouzourene, H., Ouyang, W., Iovanna, J., Renauld, J-C, and Velin, D.
- Abstract
Despite the recent description of the mucosal vaccine-induced reduction of Helicobacter pylorinatural infection in a phase 3 clinical trial, the absence of immune correlates of protection slows the final development of the vaccine. In this study, we evaluated the role of interleukin (IL)-22 in mucosal vaccine-induced protection. Gastric IL-22 levels were increased in mice intranasally immunized with urease+cholera toxin and challenged with H. felis, as compared with controls. Flow cytometry analysis showed that a peak of CD4+IL-22+IL-17+T cells infiltrating the gastric mucosa occurred in immunized mice in contrast to control mice. The inhibition of the IL-22 biological activity prevented the vaccine-induced reduction of H. pyloriinfection. Remarkably, anti-microbial peptides (AMPs) extracted from the stomachs of vaccinated mice, but not from the stomachs of non-immunized or immunized mice, injected with anti-IL-22 antibodies efficiently killed H. pylori in vitro. Finally, H. pyloriinfection in vaccinated RegIIIβ-deficient mice was not reduced as efficiently as in wild-type mice. These results demonstrate that IL-22 has a critical role in vaccine-induced protection, by promoting the expression of AMPs, such as RegIIIβ, capable of killing Helicobacter. Therefore, it can be concluded that urease-specific memory Th17/Th22 cells could constitute immune correlates of vaccine protection in humans.
- Published
- 2017
- Full Text
- View/download PDF
35. Oncogenic JAK1 and JAK2-activating mutations resistant to ATP-competitive inhibitors
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Hornakova, T., primary, Springuel, L., additional, Devreux, J., additional, Dusa, A., additional, Constantinescu, S. N., additional, Knoops, L., additional, and Renauld, J.-C., additional
- Published
- 2011
- Full Text
- View/download PDF
36. Antibody production by injection of living cells expressing non self antigens as cell surface type II transmembrane fusion protein
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Nizet, Yannick, primary, Gillet, Laurent, additional, Schroeder, Hélène, additional, Lecuivre, Corinne, additional, Louahed, J., additional, Renauld, J.-C., additional, Gianello, Pierre, additional, and Vanderplasschen, Alain, additional
- Published
- 2011
- Full Text
- View/download PDF
37. CCR8-dependent activation of the RAS/MAPK pathway mediates anti-apoptotic activity of I-309/ CCL1 and vMIP-I.
- Author
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Louahed, Jamila, Struyf, Sofie, Demoulin, Jean-Baptiste, Parmentier, Marc, Van Snick, Jacques, Van Damme, Jo, Renauld, J-C, Louahed, Jamila, Struyf, Sofie, Demoulin, Jean-Baptiste, Parmentier, Marc, Van Snick, Jacques, Van Damme, Jo, and Renauld, J-C
- Abstract
We have previously shown that the CC-chemokine 1-309 (CCL1) protects mouse thymic lymphomas against corticoid-induced apoptosis. Here, we analyzed the signal transduction pathways involved in this activity on BW5147 lymphoma. Inhibition of the CCL1 activity by pertussis toxin suggested the involvement of a G protein-coupled chemokine receptor. The role of CCR8 was supported by the observation that vMIP-I, another CCR8-ligand identified from the genome of a T cell transforming herpes virus, shared CCL1 anti-apoptotic activity. In addition to CCR8, BW5147 cells also expressed the CXCR4 receptor but its ligand, SDF-1 (CXCL12) showed only a modest anti-apoptotic activity. Other chemokines acting on CCR2, CCR4 and CCR5 failed to protect against apoptosis and to induce BW5147 chemotaxis, suggesting that these receptors were not functionally expressed. By contrast, both CCL1 and vMIP-I up-regulated ERK1/2 MAPK phosphorylation in BW5147 cells. Further analysis demonstrated that CCL1 activates the MAPK pathway in CCR8-transfected CHO cells. The implication of this pathway was confirmed by the fact that PD98059, an inhibitor of MEK kinases, as well as a dominant negative isoform of the M-RAS protein specifically blocked the anti-apoptotic activity of CCL1., Journal Article, Research Support, Non-U.S. Gov't, FLWIN, info:eu-repo/semantics/published
- Published
- 2003
38. Interleukin-9 promotes eosinophilic rejection of mouse heart allografts.
- Author
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Poulin, Lionel, Richard, Mélisande, Le Moine, Alain, Kiss, Robert, McKenzie, Andrew, Goldman, Michel, Renauld, J-C, Van Snick, Jacques, Braun, Michel Y, Poulin, Lionel, Richard, Mélisande, Le Moine, Alain, Kiss, Robert, McKenzie, Andrew, Goldman, Michel, Renauld, J-C, Van Snick, Jacques, and Braun, Michel Y
- Abstract
BACKGROUND: Eosinophils participate in allograft rejection when donor-reactive helper T lymphocytes are T-helper type 2 (Th2)-biased. Whereas the involvement of interleukin (IL)-4 and IL-5 in these forms of rejection is well established, the role of IL-9, another Th2-type cytokine promoting eosinophilia, has not been determined. METHODS: We first used real-time polymerase chain reaction to quantify IL-9 mRNA in rejected allografts in a mouse model of fully mismatched heart transplantation in which recipients were devoid of CD8 T cells and developed a Th2 alloimmune response. We then compared allograft survival in wild-type versus IL-9-deficient mice depleted of CD8 T cells. Finally, we compared the fate of major histocompatibility complex class II-mismatched cardiac transplants from wild-type versus IL-9 transgenic donors to determine the influence of IL-9 overexpression within the graft. RESULTS: The Th2 alloimmune response in CD8-deficient mice was associated with the accumulation of IL-9 mRNA in the rejected graft. In IL-9-deficient recipients depleted of CD8 T cells, eosinophil infiltration of heart allografts did not develop, but rejection still occurred. In the major histocompatibility complex class II disparate model, heart allografts from IL-9 transgenic donors were acutely rejected, whereas grafts from wild-type donors did not develop rejection. Acute rejection of IL-9 transgenic hearts was associated with massive eosinophil infiltration and prevented by neutralization of either IL-4 or IL-5. CONCLUSION: IL-9 is critically involved in heart transplant eosinophilia in conjunction with IL-4 and IL-5., Journal Article, Research Support, Non-U.S. Gov't, info:eu-repo/semantics/published
- Published
- 2003
39. IL-22 defines a novel immune pathway of antifungal resistance
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De Luca, A, primary, Zelante, T, additional, D'Angelo, C, additional, Zagarella, S, additional, Fallarino, F, additional, Spreca, A, additional, Iannitti, R G, additional, Bonifazi, P, additional, Renauld, J-C, additional, Bistoni, F, additional, Puccetti, P, additional, and Romani, L, additional
- Published
- 2010
- Full Text
- View/download PDF
40. Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22
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de Moura, P.R., primary, Watanabe, L., additional, Bleicher, L., additional, Colau, D., additional, Dumoutier, L., additional, Lemaire, M.M., additional, Renauld, J.-C., additional, and Polikarpov, I., additional
- Published
- 2009
- Full Text
- View/download PDF
41. Dissection Of The Role Of Il-9/il-9r-pathway In Murine Systemic And Intestinal Anaphylaxis.
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Osterfeld, H.N., primary, Ahrens, R., additional, Wu, D., additional, Forbes, E., additional, Finkelman, F., additional, Renauld, J., additional, and Hogan, S., additional
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- 2009
- Full Text
- View/download PDF
42. Crystal structure of the IL-22/IL-22R1 complex
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Bleicher, L., primary, de Moura, P.R., additional, Watanabe, L., additional, Colau, D., additional, Dumoutier, L., additional, Renauld, J.-C., additional, and Polikarpov, I., additional
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- 2008
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- View/download PDF
43. IL-9/IL-9 receptor signaling selectively protects cortical neurons against developmental apoptosis
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Fontaine, R H, primary, Cases, O, additional, Lelièvre, V, additional, Mesplès, B, additional, Renauld, J-C, additional, Loron, G, additional, Degos, V, additional, Dournaud, P, additional, Baud, O, additional, and Gressens, P, additional
- Published
- 2008
- Full Text
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44. Differential regulation by phorbol myristate acetate of IFN-gamma and IL-4 expression in anti-CD3 stimulated mouse spleen cells
- Author
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Monteyne, P, Renauld, J C, Coutelier, J P, and UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
- Subjects
Antigens, Differentiation, T-Lymphocyte ,Interferon Type II ,CD3 Complex ,Receptors, Antigen, T-Cell ,Gene Expression ,Mice, Inbred Strains ,Blotting, Northern ,Lymphocyte Activation ,Polymerase Chain Reaction ,Antigens, CD3 ,Interferon-gamma ,Mice ,Animals ,Tetradecanoylphorbol Acetate ,Interleukin-4 ,Spleen ,Research Article - Abstract
Expression of messenger RNA (mRNA) specific for two cytokines representative of both Th1 and Th2 cell subtypes, interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) respectively, was analysed in murine spleen cells stimulated in vitro with an anti-CD3 monoclonal antibody (mAb). This stimulation induced predominantly an IFN-gamma message. In contrast, in the presence of phorbol myristate acetate (PMA), the expression of IFN-gamma was decreased whereas the IL-4 message was dramatically enhanced. These results were confirmed by Polymerase Chain Reaction (PCR) analysis and extended to include another T-cell activator [Concanavalin A (Con A)]. The results suggest the existence of a differential pathway of activation for the Th subpopulations or a differential regulation of the T helper lymphokine gene expression by PMA-induced signals.
- Published
- 1992
45. JAK kinases overexpression promotes in vitro cell transformation
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Knoops, L, primary, Hornakova, T, additional, Royer, Y, additional, Constantinescu, S N, additional, and Renauld, J-C, additional
- Published
- 2007
- Full Text
- View/download PDF
46. Divergent roles of IFNs in the sensitization to endotoxin shock by lactate dehydrogenase-elevating virus
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Le-Thi-Phuong, T., primary, Dumoutier, L., additional, Renauld, J.-C., additional, Van Snick, J., additional, and Coutelier, J.-P., additional
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- 2007
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- View/download PDF
47. IL-9 promotes anti-Mycobacterium leprae cytotoxicity: involvement of IFNγ
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Finiasz, M R, primary, Franco, M C, additional, De La Barrera, S, additional, Rutitzky, L, additional, Pizzariello, G, additional, Del Carmen Sasiain, M, additional, Renauld, J-C, additional, Van Snick, J, additional, and Fink, S, additional
- Published
- 2006
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- View/download PDF
48. CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-22
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Nagem, R.A.P., primary, Colau, D., additional, Dumoutier, L., additional, Renauld, J.-C., additional, Ogata, C., additional, and Polikarpov, I., additional
- Published
- 2003
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- View/download PDF
49. IL-12 inhibits in vitro immunoglobulin production by human lupus peripheral blood mononuclear cells (PBMC)
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Houssiau, F A, Mascart, Françoise, Stevens, M, Libin, M, Devogelaer, J.-P., Goldman, Michel, Renauld, J-C, Houssiau, F A, Mascart, Françoise, Stevens, M, Libin, M, Devogelaer, J.-P., Goldman, Michel, and Renauld, J-C
- Abstract
Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by polyclonal B cell activation and by the production of anti-double-stranded (ds) DNA antibodies. Given the inhibitory effects of IL-12 on humoral immune responses, we investigated whether IL-12 displayed such an activity on in vitro immunoglobulin production by SLE PBMC. Spontaneous IgG, IgG1, IgG2, IgG3 and IgM antibody production was dramatically reduced by addition of IL-12. These results were confirmed by Elispot assays detecting IgG- and anti-dsDNA-secreting cells. While IL-6 and TNF titres measured in PBMC supernatants were not modified by addition of IL-12, interferon-gamma (IFN-gamma) titres were up-regulated and IL-10 production down-regulated. Since addition of IFN-gamma did not down-regulate immunoglobulin production and since the inhibitory activity of IL-12 on immunoglobulin synthesis was not suppressed by anti-IFN-gamma antibody, we concluded that the effect of IL-12 on immunoglobulin production was not mediated through IFN-gamma. Our data also argue against the possibility that down-regulation of endogenous IL-10 production was responsible for the effect of IL-12. Thus, inhibition of IL-10 production by IFN-gamma was not accompanied by inhibition of immunoglobulin production, and conversely, restoration of IL-10 production by anti-IFN-gamma antibody did not suppress the inhibitory activity exerted by IL-12 on immunoglobulin production. Taken together, our data indicate that reduction of excessive immunoglobulin and anti-dsDNA antibody production by lupus PBMC can be achieved in vitro by IL-12, independently of IFN-gamma and IL-10 modulation., Journal Article, Research Support, Non-U.S. Gov't, FLWIN, info:eu-repo/semantics/published
- Published
- 1997
50. Oxidative burst in lipopolysaccharide-activated human alveolar macrophages is inhibited by interleukin-9
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Pilette, C., primary, Ouadrhiri, Y., additional, Van Snick, J., additional, Renauld, J-C., additional, Staquet, P., additional, Vaerman, J-P., additional, and Sibille, Y., additional
- Published
- 2002
- Full Text
- View/download PDF
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