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1. Systematic review and meta-analysis of the safety of chloroquine and hydroxychloroquine from randomized controlled trials on malarial and non-malarial conditions

Author

Mayra Souza Botelho, Fernanda Bolfi, Renata Giacomini Occhiuto Ferreira Leite, Mauro Salles Ferreira Leite, Luisa Rocco Banzato, Luiza Teixeira Soares, Thaina Oliveira Felicio Olivatti, Amanda Sampaio Mangolim, Flávia Ramos Kazan Oliveira, Luciana Patrícia Fernandes Abbade, Joelcio Francisco Abbade, Ricardo Augusto Monteiro de Barros Almeida, Julia Simões Corrêa Galendi, Lehana Thabane, and Vania dos Santos Nunes-Nogueira

Subjects
Chloroquine, Hydroxychloroquine, COVID-19, Adverse effects, Safety, Systematic review, Medicine
Abstract

Abstract Background Despite the expectations regarding the effectiveness of chloroquine (CQ) and hydroxychloroquine (HCQ) for coronavirus disease (COVID-19) management, concerns about their adverse events have remained. Objectives The objective of this systematic review was to evaluate the safety of CQ and HCQ from malarial and non-malarial randomized clinical trials (RCTs). Methods The primary outcomes were the frequencies of serious adverse events (SAEs), retinopathy, and cardiac complications. Search strategies were applied to MEDLINE, EMBASE, LILACS, CENTRAL, Scopus, and Trip databases. We used a random-effects model to pool results across studies and Peto’s one-step odds ratio (OR) for event rates below 1%. Both-armed zero-event studies were excluded from the meta-analyses. We used the Grading of Recommendations Assessment, Development, and Evaluation system to evaluate the certainty of evidence. Results One hundred and six RCTs were included. We found no significant difference between CQ/HCQ and control (placebo or non-CQ/HCQ) in the frequency of SAEs (OR: 0.98, 95% confidence interval [CI]: 0.76–1.26, 33 trials, 15,942 participants, moderate certainty of evidence). However, there was a moderate certainty of evidence that CQ/HCQ increases the incidence of cardiac complications (RR: 1.62, 95% CI: 1.10–2.38, 16 trials, 9908 participants). No clear relationship was observed between CQ/HCQ and retinopathy (OR: 1.63, 95% CI: − 0.4–6.57, 5 trials, 344 participants, very low certainty of evidence). Conclusions CQ and HCQ probably do not increase SAEs, with low frequency of these adverse events on malarial and non-malarial conditions. However, they may increase cardiac complications especially in patients with COVID-19. No clear effect of their use on the incidence of retinopathy was observed. Systematic review registration PROSPERO CRD42020177818

Published
2021
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2. Effectiveness of strategies for nutritional therapy for patients with type 2 diabetes and/or hypertension in primary care: protocol of a systematic review of randomised controlled trials

Author

Julia Simões Corrêa Galendi, Renata Giacomini Occhiuto Ferreira Leite, Adriana Lúcia Mendes, and Vania dos Santos Nunes-Nogueira

Subjects
Medicine
Abstract

Introduction Despite the increasing number of drugs available and various guidelines on the management of type 2 diabetes mellitus (T2DM) and hypertension, an expressive number of patients continue with these diseases uncontrolled. Nutrition therapy (NT) plays a fundamental role in the prevention and management of these comorbidities, as well as in the prevention of complications related to them. The objective of this review is to evaluate the effectiveness of NT strategies in the management of patients with T2DM and/or hypertension in primary care. The selected strategies did not substitute pharmaceutical treatment but instead focused on preventing a sedentary lifestyle and stimulating healthy nutrition.Methods and analysis We will perform a systematic review according to Cochrane methodology of randomised controlled trials, wherein patients with T2DM and/or hypertension were allocated into one of the two groups: NT strategy, which may be of dietary quality or energy restriction, and conventional treatment. The primary outcomes will be glycaemic and blood pressure (BP) control, measured by final glycosylated hemoglobin (HbA1c) (%) and BP (mm Hg), respectively. Four general and adaptive search strategies have been created for the Embase, Medline, Latin American and Caribbean Health Sciences Literature (LILACS) and Cochrane Central Register of Controlled Trials (CENTRAL) electronic databases. Two reviewers will independently select eligible studies, assess the risk of bias and extract data from the included studies. Similar outcomes measured in at least two trials will be plotted in the meta-analysis using Review Manager V.5.3. The quality of evidence of the effect estimate of the intervention will be generated according to the Grading of Recommendations Assessment, Development, and Evaluation Working Group.Ethics and dissemination As no primary data collection will be undertaken, formal ethical assessment is not required. We plan to present the results of this systematic review in a peer-reviewed scientific journal, conferences and the popular press.PROSPERO registration number Our systematic review protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) on 20 December 2018 (Registration number CRD42018118117).

Published
2019
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3. Effectiveness of Strategies for Nutritional Therapy for Patients with Type 2 Diabetes and/or Hypertension in Primary Care: A Systematic Review and Meta-Analysis

Author

Julia Simões Corrêa Galendi, Renata Giacomini Occhiuto Ferreira Leite, Luísa Rocco Banzato, and Vania dos Santos Nunes-Nogueira

Subjects
Glycated Hemoglobin, endocrine system diseases, Diabetes Mellitus, Type 2, Primary Health Care, Health, Toxicology and Mutagenesis, Hypertension, Public Health, Environmental and Occupational Health, nutritional and metabolic diseases, Humans, Blood Pressure
Abstract

A central aspect to the management of type 2 Diabetes Mellitus (T2DM) and hypertension is promoting a healthy lifestyle, and nutritional therapy (NT) can support patients achieving glycemic control and blood pressure targets. This systematic review aimed to evaluate the effectiveness of NT in the management of patients with T2DM and/or hypertension in primary care. Primary outcomes were HbA1c, systolic blood pressure (SBP) and diastolic blood pressure (DBP). Thirty-nine studies were included, thirty on T2DM and nine on hypertension. With a moderate quality of evidence, educational/counseling programs and food replacement programs in primary care likely reduce HbA1c on patients with T2DM (mean difference (MD): −0.37, 95% CI: −0.57 to −0.17, 7437 patients, 27 studies; MD: −0.54, 95% CI: −0.75 to −0.32, 440 patients, 2 studies, respectively). Mediterranean diet for T2DM was accessed by one study, and no difference between the groups was found. Educational and counseling programs likely reduce DBP in patients with hypertension (MD: −1.79, 95% CI: −3.46, −0.12, 2840 patients, 9 studies, moderate quality of the evidence), but the effect in SBP was unclear due to risk of bias and imprecision. Nutritional therapy strategies (i.e., educational/counseling programs and food replacement programs) in primary care improved HbA1c in patients with T2DM and DBP in individuals with hypertension.

Published
2022

4. Endocrinologia e Imunologia

Author

Henrique Mota Dias Gabriel da Silva, Paula Gouvêa Abrantes, Fábio Giancoli Jabour, GABRIELA DE PAULA FAGUNDES NETTO, Álvaro Maciel Campos Resende, Rafael Matoso de Oliveira Figueiredo, HUGO DUARTE MASCARENHAS DE CASTRO, Gabriela Carneiro Neves, André Mourão Costa Lima, Danielle Souza Silva, Dhener Gonzaga Abade, Gabriel Cavalcanti de Mello Moura, João Vitor Prado Rodrigues, José Reinaldo Corrêa Roveda, Olívio Marques Brum, Rayan Viana das Chagas, JAQUELINE VASCONCELOS DA SILVA GUSMÃO, Paula schatz de Gusmão Lyra Cavalcanti, CAMILA YANDARA SOUSA VIEIRA DE MELO, Vitor Augusto Pereira de Carvalho, Bruna Cappelli Coutinho, Bruno de Oliveira Vaz Lanza, Abraão Mendes Peixoto, Bruno Lucas de Andrade, Pedro Duarte Moreira Andrade, Vinícius Nunes Soares, Vitória Moraes de Campos Belo, Rodrigo Tavares de Lanna Rocha, João Victor Cota Postali, Larissa Verçosa Tramontina, Pedro Antônio Oliveira Aquino Gusmão, Victor Buchini de Freitas, Beatriz Saez Bragança Rezende, Gabriela Freitas Moreira, Mariana Santos de Andrès Abreu, João Henrique Vilaça Santiago, Gabriela Vaz Campos, Letícia Fogaça Saud, Livia Viana Trevisan, Daniela Vieira e Silva Vitor, Stefani Z Monção, Camilla Caramaschi Vernizzi, Gretha Faber Bortolan, Bárbara Mamede Silva Machado, Marcelo Eduardo Ramos Barbosa, Gabriela da Silva Cervi Machado, Maria Luiza Ricarte Ruggeri, RAFAELA SILVEIRA XIMENES DE SOUZA, Ana Raquel Whitaker Filipe, Carla Rossini Crepaldi, Mila Pontes Ramos Cunha, Eugênia M de Q F B da Silveira, Iris Lopes Veras, Ana Beatriz de Alexandria Leal Vasconcelos, Márcia Gomes Marinheiro Coelho, Fernanda Pimentel de Oliveira, Mateus Sampaio Coelho, Isabela de Araújo Belo Passos, Gabriely de Oliveira, Angel Adriany da Silva, Silvia Regina Seibel de Matos, Gustavo Henrique Sumnienski Bertoldi, Isabela Yurie Yamada, Gabriela Somma Gomes, Sofia Landim Teixeirense Pinheiro, Letícia Elen Carpenedo Frare, Milena Gonçalves Guerreiro, Joanna Lara Castelo Rodrigues, Mary Morioka, Bruna Duz, Julio Soares Curi, Caroline Brand, Cézane Priscila Reuter, Marcos Fonseca Melo, Ana Clara Rosa, Gabriel Araújo Moura Leite, Géssyca Tolomeu de Oliveira, Gustavo Sabec Folgueral, Hygor Cordeiro Fontes, Laila Fernandes da Cunha, Luciana Siuves Ferreira Couto, Victor Miguel Fernandes de Moraes, Vítor Luiz Rocha Rodrigues, Vitória Dias Dos Santos, Leticia Ferreira Santos Brito, Lucas Reis Oliveira, Bianca Santos Melo, Katlhen Cruz Santana, Bruna Passos Santos, Yane Passos de Oliveira, Mariana Moraes Vieira, Maria Beatriz Meneses Melo, João Victor Oliveira Prado, Tássia Virgínia de Carvalho Oliveira, SAMUEL MELO RIBEIRO, Mauro Marques Lopes, Jhennifer Stephanye Venturato Vieira, Gustavo Coutinho Nogueira Pereira, BIANCA RODRIGUES TAVARES, Juliana Vieira Gama, MARCOS ANTÔNIO RIBEIRO MENDES, Ana Carolina de Sousa Andrade, Caroline Souza Araújo, Laís Correa Marques, Maria Nila Sutana de Mendonça, Thainã Medeiros de Souza Andrade, Renata Giacomini Occhiuto Ferreira Leite, Elomar Rezende Moura, Victoria de Andrade Santos, Leticia Rocha Sobral, ryan fernando menezes, Kamille Costa Nunes, Alessandra Vitoria de Menezes Nunes, Julia Alves Santos, Lorena dos Santos Blinofi Cruz, Izabelle de Lourdes Pereira Ribeiro, Halley Ferraro Oliveira, Clara Lopes Lima, Laura de Araujo SOARES, Beatriz Maria Monteiro Souza, Vinícius Fonseca Bernardes, Gustavo Junho Toledo, Helena de Cunha Lopes Lima, Laura Teodoro Campos Faleiros, Mateus Gomes Polo, Rafaela Silveira Ximenes de Souza, Rosinês Padilha da Silva, Liliana Portal Weber, Luísa Santiago Ramos, Ana Clara Resende Rodrigues, Eduarda Viana de Souza, Gabriel Oliveira Souza, Igor Tomoyuki Kamino, Paulo Augusto Carvalho Miranda, Andressa Mendes de Sousa, Myrna Beatriz de Melo Oliveira, Larissa Mota Oliveira, Marcely Juliana Silva de Meneses, Bárbara Cândida Nogueira Piauilino, Carlos Daniel de Sousa Lima, Maria Clara Leal Cortez, Maria Luana de Moura Sousa, Lucas Ferrari da Silva Mendes, Amanda Vitória da Rocha Granja, Maysa Mauriz de Galiza Robatini Ramos, Ramona Dias Horta, Alice Maia Marinho de Andrade, Christian Diego Hernández Camacho, Kittaro Oittavo Moreira Teixeira da Luz, Lucas Henrique de Carvalho Machado, MARIANA NUNES LIMA DIAS, Gabriela Dantas Carvalho, Rayssa Maria de Araújo Carvalho, Klégea Maria Cândido Ramos Carvalho, Rebeca Múálem de Moraes Santos, Guilherme Barroso, Ana Carvalho Kilson, André Mendonça Palhares, Bruno Guerra Paiva, Carlos Augusto Wolmer de Carvalho Rocha, Chiara Giovanna de Paiva Ayres, Cibele Morais da Vitória, Felipe Barros, Gabriel Chaves Rettore Leandro, Gabriela Cordeiro Costa, Giovanna Galantini Silveira, Isabela Galantini Silveira, Isabela Soares Bôa Morte, Isabella Zechlinski Machado, Laura Tomaz Silva, Luiz Francisco Campos Freitas, Luiz Sequeira Fernandes, Luiza de Souza Cabral, Maria Júlia Giraud Mansilha, Mariana Madureira Frois, Mariana Ribeiro Nobre, Nicholas Franco SantAna Medeiros, Rafaela Pessoa Alves Luso, Renata Viana Hoffmann Monteiro Guedes, Stella Assis Guerra, Thaila Bastos Silva da Cruz, Paula Melo Vale, Thaís Toledo Nora, Rachel Calazans de Oliveira Costa, Victor Silame Braga, Vitoria Grecco Collodetti, Júlia Bueno Nascimento Jannotti, Natália Campos Ramos, Juliana Gonzaga Araújo Clark, Ulisses Guimarães Fernandes, Leandro Petronetto Loureiro, Pedro Terra De Martin Galito, Felipe Terra De Martin Galito, Higor Fontana Nicoli, Vinicios Teixeira de Carvalho Soares, Eduarda Maria Cetto Meira, Pedro Flavio Antunes Gallo Pinheiro, Carla Gomes da Silva Lacerda, Ramon Machado Avelar, Nádya Ribeiro Corrêa, João Paulo Pereira Martins, Juliana Aguiar Cavalcante Diniz, Juliana de Assis Pires, Karenn Tavares Kiepper, Maria Carolina Gonçalves Lana, Natália Andrade Lanna, Tatiana Borges Quadros, Matheus Neres Batista, Weberton Dorásio Sobrinho, Joel A S, Eliana A N Veloso, Karolinne Dorneles Dias, Amanda Carolina de Melo Gonçalves, Laura Vilela Buiatte Silva, Carla Azevedo Zaibak, Bianca Vieira de Sousa, Nathálya Faria Alves, Lanna do Carmo Carvalho, Luciano Souza Magalhães, Luana Vilela Matos, Layanne Cintra Soares, Paula Castro Ferreira, Isys de Paula, Letícia Priscila dos Anjos Goulart, Laura Vitória Melo Gomes, Beatriz Cozzer, Ana Clara Gambarini Mello, Lara Gouvêa de Azevedo, Beatriz Teixeira Lodi, Kelly Cristina Mota Braga Chiepe, Gustavo Henrique Silva Sidrim, Marina Oliveira Quinto, Ianca Siqueira Libânio, Paula Luiza Isabella Cruz, Mariana de Fátima Rodrigues da Silva, Letícia de Castro Nascimento, Bárbara Viana Marchesi, Gabriella Rocha Vilela, Renzo Câmara Arreguy, Isabella Almeida Sá, Cíntia Dias Vieira Bemfica, Milena Aguiar de Oliveira, Stefani Zaqué Monção, Débora Silva Ciríaco, Bruna Piassi Guaitolini Vargas, Marina Alvarenga Andrade Siqueira, Júllia Beatriz Araujo Souza, Ana Luiza Almeida Menezes, Beatriz Oliveira Santos, Edson Santana Gois, Eduarda Lavínia Carneiro Santos, João Victor Santos Melo, Leila Maria Lemos Nascimento, Mariana Sattler Lima Medina, Rosa Carolina Santos De Oliveira, Vitória Dias dos Santos, Igor Silva Matias, Aalec Rinhel, Andrei Biliato Colmanetti, Amanda Pita Oliveira, Filipe Abrão Borges Salomão, Guilherme Assis Xavier, Lívia dos Santos Souza, Marcela Mamede Elias, Mateus Nascimento Barbosa Barros, Murilo Pita Oliveira, Paula Cristina Santos Soares, Thales Milhorim da Silva, Ana Theresa Simões Rosa Borges, Maria Luiza Costa Santos, Sophia Mourão Gontijo de Castro, Mariane da Mata Morato Mendes, Eduarda Paula Markus Xavier, Ranieri Alvin Stroher, André Luiz Cezar, Ana Elisa Choucair Hosken Arão, Anna Carlinda Arantes de Almeida Braga, Igor Yury Silva, Gabriela de Alcântara Fonseca, Ariel Eugênio Salgueiro de Almeida, Vitor Medeiros Delgado, Patrícia Oliveira Lima de Macedo, Louyse Jerônimo de Morais, Júlio César Benjamim Moreira Silva, Vitor Rodrigues de Miranda, Bárbara Coelho Pereira, Amanda Barros França, Danielle Ribeiro Duarte, Ana Paula Tobias Antunes, Sophia Avelar Freitas, Priscilla Martins Valadares, Helena Rodrigues de Miranda, Luísa De Luca Felicíssimo, Rafaella Moreira Gonçalves Magalhães, Maria Laura Pires de Carvalho Pereira, Luiza Aguiar Puff, Larissa Chaves Teodoro, Fernanda Gualberto Costa Campos, Tiago Pessoa Mendes, Flávia Chaves Cardoso de Paula, Arthur Andrade Brum, João Pedro Campos Pereira, Fernanda Valcarenghi, Guilherme Amaral Stangherlini, Ana Carolina Porciuncula de Ávila, Murillo Cesar Gionedis, Elise Cristina Reolon de Mello, Ana Carolina Ballardin, Gabriel Michelin De Carli, Rafaela Dresch Pereira, Amanda Marques Coelho, Davidson de Lima Cavassola, Giovanna de Carvalho Meneses Costa, Maria Júlia Ribeiro da Costa, Vinícius Leite Siebra, Bruno Araújo Rocha, Carlos Wesley Ribeiro Pereira, Felipe Gomes da Silva, Francisco Socorro Rocha, Gabriel Melo de Sousa, Jadsonn Souza de Melo, Lorena Terra Campos, Alice Maciel de Lacerda, Artur Moreira Rodrigues, Bárbara Ribeiro Diniz, Bruna Pereira Vilaça, Matheus Álvaro Colbert Câmara, Pedro Alcântara Antunes Lopes, Bárbara Campolina Carvalho e Silva, Bárbara Belloni Perez Couto, Izabella Pereira Chaves, Lucas Pinheiro Costa, Letícia Freitas de Castro Silva, Elisa Pinheiro Weber, Debbie Priscila Weber, Ana Clara Moreira Noronha Fonseca, Bárbara Luiza Klein, Jamile Cássia Gonçalves Aniceto Ferreira, Maria Eduarda Tavares de Oliveira, Maria Fernanda Luz Silva, Kawanny Kennedy de Arruda Batista, Milena Maria da Silva Aguiar, Fabiano dos Santos, Geovani Andriel Alves Martiniano da Silva, Letícia Kelly Melo Santana, Lívia Leandro de Souza Pereira, Maria Eduarda Osório Marafante, Weslley Jonathan Lopes da Penha, PAULA FONTES LELIS, Juliana Souza Martins, Júlia Gatti Ladeia Costa, Ana Laura Martins Marra Magno Lucindo, Gabriella Soares de Souza, Tiago Araújo Monteiro, Estevão Curado Domingues, Leilianny Alencar Secundino Curado, Amanda Holanda de Mesquita, Aline Castro de Almeida, Isabela Araujo Schmidt, Laura Krepk Vieira, Breno Veggi Godinho, Olívia Féres Varela, Lara Bastos Spinelli Pinto, Cecília Barra de Oliveira Hespanhol, Letícia F Soares, Matheus Itaborai de Castro Nogueres, Thais Sette Espósito, Amanda do Carmo Gusmão, Andressa de Araujo Rodrigues, Daniela O W Rodrigues, Patricia Pimenta Nunes, Hellen Louize Pacheco di Firmo, Laiane Cristina De Camargos Silva, Luiza Lacerda Lima, Lara Campos Martins, Luiza Fernandes Rios, Beatriz Campos Garcia, Giovana Campos Garcia, Cecilia Miranda Gonçalves, Gabriella Bretas Alves, Nayla Fernanda de Oliveira Tanus, Gustavo de Moura Campos, Vitória Guerra Melo, Alice Costa Duarte, Isadora Pessoa Coimbra Rabello, Ana Julia Amaral Melo, Maria Carla Silva Teixeira, lara Resende Melgaço, Marielle Caroline Barcelos, Caroline Marinho Simião, Giulia Cazzoletti, Marina Silveira Braga, Luísa Guerra Brandão, Rafael Bessa Fleming, Sophia Filgueiras Vieira, ANA CAROLINA AMORIM OLIVEIRA, Eduarda Santana dos Santos, George Lucas Santos Pereira, Juliana Thalia Souza de Moura, Lara Santana Bastos, Larissa Gusmão Guimarães, Julianne Alves Machado, Maria Ingrid Ferreira Dias Gregório, Luana Pereira da Silva, Ráira Thiele Ribeiro FEITOSA, Sarah Buarque Gomes de Moura, Lívia Maria Alves de Souza, Fabiana Oliveira dos Santos Gomes, Caio Fossalussa da Silva, Anny Isabelly dos Santos Souza, Fabio Franceschini Mitri, João César Guimarães Henriques, Raquel Carmo Araújo, Gabriela de Oliveira Carvalho, Matheus Jannuzzi Moreira de Mendonça, Vitória Aparecida Cunha, and Pamela Andrea Alves Durães

Published
2021
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6. Effectiveness of strategies for nutritional therapy for patients with type 2 diabetes and/or hypertension in primary care: Protocol of a systematic review of randomised controlled trials

Author

Renata Giacomini Occhiuto Ferreira Leite, Julia Simões Corrêa Galendi, Adriana Lúcia Mendes, Vania dos Santos Nunes-Nogueira, and Universidade Estadual Paulista (Unesp)

Subjects
medicine.medical_specialty, hypertension, type 2 diabetes mellitus, MEDLINE, 030209 endocrinology & metabolism, Type 2 diabetes, 03 medical and health sciences, 0302 clinical medicine, systematic review, Protocol, medicine, Humans, Hypoglycemic Agents, 030212 general & internal medicine, Medical nutrition therapy, Intensive care medicine, Antihypertensive Agents, Randomized Controlled Trials as Topic, Sedentary lifestyle, Protocol (science), Primary Health Care, business.industry, General Medicine, medicine.disease, meta-analysis, primary health care, Diabetes and Endocrinology, Systematic review, Diabetes Mellitus, Type 2, Research Design, Meta-analysis, Diet, Healthy, business, nutrition therapy, Systematic Reviews as Topic, Biomedical sciences
Abstract

Made available in DSpace on 2019-10-06T16:46:13Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-09-01 Introduction Despite the increasing number of drugs available and various guidelines on the management of type 2 diabetes mellitus (T2DM) and hypertension, an expressive number of patients continue with these diseases uncontrolled. Nutrition therapy (NT) plays a fundamental role in the prevention and management of these comorbidities, as well as in the prevention of complications related to them. The objective of this review is to evaluate the effectiveness of NT strategies in the management of patients with T2DM and/or hypertension in primary care. The selected strategies did not substitute pharmaceutical treatment but instead focused on preventing a sedentary lifestyle and stimulating healthy nutrition. Methods and analysis We will perform a systematic review according to Cochrane methodology of randomised controlled trials, wherein patients with T2DM and/or hypertension were allocated into one of the two groups: NT strategy, which may be of dietary quality or energy restriction, and conventional treatment. The primary outcomes will be glycaemic and blood pressure (BP) control, measured by final glycosylated hemoglobin (HbA1c) (%) and BP (mm Hg), respectively. Four general and adaptive search strategies have been created for the Embase, Medline, Latin American and Caribbean Health Sciences Literature (LILACS) and Cochrane Central Register of Controlled Trials (CENTRAL) electronic databases. Two reviewers will independently select eligible studies, assess the risk of bias and extract data from the included studies. Similar outcomes measured in at least two trials will be plotted in the meta-analysis using Review Manager V.5.3. The quality of evidence of the effect estimate of the intervention will be generated according to the Grading of Recommendations Assessment, Development, and Evaluation Working Group. Ethics and dissemination As no primary data collection will be undertaken, formal ethical assessment is not required. We plan to present the results of this systematic review in a peer-reviewed scientific journal, conferences and the popular press. PROSPERO registration number Our systematic review protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) on 20 December 2018 (Registration number CRD42018118117). Department of Internal Medicine São Paulo State University (UNESP) Medical School Department of Internal Medicine São Paulo State University (UNESP) Medical School

Published
2019

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