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This study investigates the integration of word-initial fundamental frequency (F0) and voice-onset-time (VOT) in stop voicing categorization for adult listeners with normal hearing (NH) and unilateral cochlear implant (CI) recipients utilizing a bimodal hearing configuration [CI + contralateral hearing aid (HA)]. Categorization was assessed for ten adults with NH and ten adult bimodal listeners, using synthesized consonant stimuli interpolating between /ba/ and /pa/ exemplars with five-step VOT and F0 conditions. All participants demonstrated the expected categorization pattern by reporting /ba/ for shorter VOTs and /pa/ for longer VOTs, with NH listeners showing more use of VOT as a voicing cue than CI listeners in general. When VOT becomes ambiguous between voiced and voiceless stops, NH users make more use of F0 as a cue to voicing than CI listeners, and CI listeners showed greater utilization of initial F0 during voicing identification in their bimodal (CI + HA) condition than in the CI-alone condition. The results demonstrate the adjunctive benefit of acoustic hearing from the non-implanted ear for listening conditions involving spectrotemporally complex stimuli. This finding may lead to the development of a clinically feasible perceptual weighting task that could inform clinicians about bimodal efficacy and the risk-benefit profile associated with bilateral CI recommendation.

The middle-ear system relies on a balance of mass and stiffness characteristics for transmitting sound from the external environment to the cochlea and auditory neural pathway. Phase is one aspect of sound that, when transmitted and encoded by both ears, contributes to binaural cue sensitivity and spatial hearing. The study aims were (i) to investigate the effects of middle-ear stiffness on the auditory brainstem neural encoding of phase in human adults with normal pure-tone thresholds and (ii) to investigate the relationships between middle-ear stiffness-induced changes in wideband acoustic immittance and neural encoding of phase. The auditory brainstem neural encoding of phase was measured using the auditory steady-state response (ASSR) with and without middle-ear stiffness elicited via contralateral activation of the middle-ear muscle reflex (MEMR). Middle-ear stiffness was quantified using a wideband acoustic immittance assay of acoustic absorbance. Statistical analyses demonstrated decreased ASSR phase lag and decreased acoustic absorbance with contralateral activation of the MEMR, consistent with increased middle-ear stiffness changing the auditory brainstem neural encoding of phase. There were no statistically significant correlations between stiffness-induced changes in wideband acoustic absorbance and ASSR phase. The findings of this study may have important implications for understanding binaural cue sensitivity and horizontal plane sound localization in audiologic and otologic clinical populations that demonstrate changes in middle-ear stiffness, including cochlear implant recipients who use combined electric and binaural acoustic hearing and otosclerosis patients.

To report Advanced Bionics (AB) Ultra (V1) and Ultra 3D (V1) cochlear implant (CI) electrode failures and revision speech recognition outcomes for patients at a large CI program.Retrospective case series.Tertiary referral center.Patients receiving Ultra (V1) or Ultra 3D (V1) devices as of September 21, 2021.Failure rate, revision surgery, speech recognition scores.To data, 65 (21.1%) of the 308 implanted devices are known failures, with 63 (20.5%) associated with the recent voluntary field corrective action (FCA). Average time to failure was 2.2 ± 1.1 years. Fifty-two patients (82.5%) elected for revision surgery. Among adults, immediate prerevision scores demonstrated a significant decrease from best-achieved scores with the faulty implant, with mean difference of -15.2% (p = 0.0115) for consonant-nucleus-consonant (CNC) and -27.3% (p0.0001) for AzBio in quiet. By 3 months postactivation of the revised device, CNC (p = 0.9766) and AzBio in quiet (p = 0.9501) scores were not significantly different than best prerevision scores. Overall, 15 of 19 patients regained or improved their best prerevision CNC score. The current trajectory for FCA device failures is approximately 6% per year.Compared to manufacturer reporting, a high number of patients experienced hard failures of the Ultra (V1) and Ultra 3D (V1) devices. Early identification of failures is possibly because of the diligent use of electrical field imaging testing. Most patients affected by the FCA regain or exceed their prefailure speech recognition score as soon as 3 months after revision surgery.

Visual cues are especially vital for hearing impaired individuals such as cochlear implant (CI) users to understand speech in noise. Functional Near Infrared Spectroscopy (fNIRS) is a light-based imaging technology that is ideally suited for measuring the brain activity of CI users due to its compatibility with both the ferromagnetic and electrical components of these implants. In a preliminary step toward better elucidating the behavioral and neural correlates of audiovisual (AV) speech integration in CI users, we designed a speech-in-noise task and measured the extent to which 24 normal hearing individuals could integrate the audio of spoken monosyllabic words with the corresponding visual signals of a female speaker. In our behavioral task, we found that audiovisual pairings provided average improvements of 103% and 197% over auditory-alone listening conditions in −6 and −9 dB signal-to-noise ratios consisting of multi-talker background noise. In an fNIRS task using similar stimuli, we measured activity during auditory-only listening, visual-only lipreading, and AV listening conditions. We identified cortical activity in all three conditions over regions of middle and superior temporal cortex typically associated with speech processing and audiovisual integration. In addition, three channels active during the lipreading condition showed uncorrected correlations associated with behavioral measures of audiovisual gain as well as with the McGurk effect. Further work focusing primarily on the regions of interest identified in this study could test how AV speech integration may differ for CI users who rely on this mechanism for daily communication.

Purpose: Until recently, there has been little investigation on the effects of cochlear implantation on the transmission of acoustic stimuli through the middle-ear system. Recent studies have shown that cochlear implantation decreases low-frequency acoustic absorbance, consistent with a stiffer middle-ear system postsurgery. The objectives of this study are (a) to investigate the time course of changes in acoustic absorbance post–cochlear implantation in the implanted ear and (b) to compare changes in acoustic absorbance between implanted and nonimplanted ears over time. Method: Seventeen adult cochlear implant (CI) recipients within 6 months of device activation participated in this study. Wideband acoustic absorbance was measured in both ears at one to six different time points from pre-implantation up to 6-month postactivation. Analyses examined (a) changes in acoustic absorbance as compared to pre-implantation and (b) differences in acoustic absorbance between implanted and nonimplanted ears over time. Results: Acoustic absorbance in the implanted ear decreased postsurgery for frequencies lower than 1.5 kHz and persisted through at least 6-month postactivation. We also observed that the spectral range of decreased acoustic absorbance in the implanted ear decreased with longer time postsurgery. Differences in acoustic absorbance between implanted and nonimplanted ears occurred over a broad spectral range at the activation time point and persisted through at least 3-month postactivation, though for a narrower spectral range at the later time point. Conclusions: Cochlear implantation increased middle-ear stiffness as indicated by decreased acoustic absorbance of low-frequency acoustic power. The findings of this study are consistent with those of previous studies and may have important implications toward understanding spatial hearing and programming of acoustic components for CI-combined electric and binaural acoustic stimulation patients.

Objective The primary purpose of this study was to examine the effect of acoustic bandwidth on bimodal benefit for speech understanding in pediatric cochlear implant (CI) recipients. Study design Ten children (6-13 years) with CIs utilizing a bimodal hearing configuration participated in this study. Speech understanding was assessed via recorded Pediatric AzBio sentences presented in a 10-talker babble. The CI stimulus was always unprocessed and the low-pass filtered acoustic stimuli were delivered to the non-CI ear with the following cutoff frequencies: 250, 500, 750, 1000, and 1500 Hz. Setting Tertiary referral center. Main outcome measures Sentence recognition in noise for the acoustic-alone, CI-alone, and bimodal listening conditions. Results The primary findings were: (1) children gained significant bimodal benefit with 250 Hz, and (2) children demonstrated no statistically significant additional bimodal benefit with increasing acoustic bandwidth. Conclusions Acoustic bandwidth effects for pediatric CI recipients were significantly different than those documented in the literature for adult CI recipients. Specifically, this group of pediatric CI recipients demonstrated no increases in bimodal benefit with increases in acoustic bandwidth, primarily consistent with a segregation theory of bimodal integration.

OBJECTIVE The objective was to design a questionnaire to identify daily cochlear implant (CI) use habits and barriers to daily CI use and to administer this questionnaire to adult CI users. We hypothesized that recipients who reported a greater number of barriers to daily CI use would show lower daily CI use. STUDY DESIGN Questionnaire. SETTING Academic medical center. PATIENTS Hundred adult CI recipients. MAIN OUTCOME MEASURES Questionnaire responses and amount of CI use per day as measured from the CI software. RESULTS The cochlear implant use questionnaire (CIUQ) was created and responses were obtained from 100 participants. The CIUQ yielded an average overall score of 23 (range, 3-54) out of 100; responses were variable, and CI recipients experienced different barriers to using their CI processor. The CIUQ overall score was significantly correlated with recipients' daily CI use (h/d) (rs = -0.561, p

Purpose Despite the recommendation for cochlear implant (CI) processor use during all waking hours, variability in average daily wear time remains high. Previous work has shown that objective wear time is significantly correlated with speech recognition outcomes. We aimed to investigate the causal link between daily wear time and speech recognition outcomes and assess one potential underlying mechanism, spectral processing, driving the causal link. We hypothesized that increased CI use would result in improved speech recognition via improved spectral processing. Method Twenty adult CI recipients completed two study visits. The baseline visit included auditory perception testing (speech recognition and spectral processing measures), questionnaire administration, and documentation of data logging from the CI software. Participants watched an educational video, and they were informed of the compensation schedule. Participants were then asked to increase their daily CI use over a 4-week period during everyday life. Baseline measures were reassessed following the 4-week period. Results Seventeen out of 20 participants increased their daily CI use. On average, participants’ speech recognition improved by 3.0, 2.4, and 7.0 percentage points per hour of increased average daily CI use for consonant–nucleus–consonant words, AzBio sentences, and AzBio sentences in noise, respectively. Questionnaire scores were similar between visits. Spectral processing showed significant improvement and accounted for a small amount of variance in the change in speech recognition values. Conclusions Improved consistency of processor use over a 4-week period yielded significant improvements in speech recognition scores. Though a significant factor, spectral processing is likely not the only mechanism driving improvement in speech recognition; further research is warranted.

To report our experience for adults undergoing cochlear implantation (CI) for single-sided deafness (SSD).This is a retrospective case series for adults with SSD who underwent CI between January 2013 and May 2021 at our institution. CNC and AzBio speech recognition scores, Tinnitus Handicap Inventory (THI), Speech, Spatial, and Qualities of Hearing Scale (SSQ12), datalogging, and the Cochlear Implant Quality of Life (CIQOL)-10 Global measure were utilized.Sixty-six adults underwent CI for SSD (median 51.3 years, range 20.0-74.3 years), and 57 (86.4%) remained device users at last follow-up. Compared to pre-operative performance, device users demonstrated significant improvement in speech recognition scores and achieved peak performance at six months post-activation for CNC (8.0% increased to 45.6%, p 0.0001) and AzBio in quiet (12.2% increased to 59.5%, p 0.0001). THI was decreased at 6 months post-implantation (58.1-14.6, p 0.0001), with 77% of patients reporting improved or resolved tinnitus. Patients demonstrated improved SSQ12 scores as well as the disease-specific CIQOL-10 Global questionnaire. Duration of deafness was not associated with significant differences in speech recognition performance. Average daily wear time was positively associated with CNC and AzBio scores as well as post-operative CIQOL-10 scores.Herein we present the largest cohort of adult CI recipients with SSD with data on speech recognition scores, tinnitus measures, and SSQ12. Novel insights regarding the correlation of datalogging, duration of deafness, and CI-specific quality of life (CIQOL-10) metrics are discussed. Data continue to support CI as an efficacious treatment option for SSD.IV Laryngoscope, 2022.

To characterize the influence of expanding indications on the profile of adults undergoing cochlear implantation (CI) at a high-volume CI center.Retrospective review.Tertiary referral center.774 adults undergoing CI evaluation from August 2015 to August 2020.Demographics; audiometry; speech recognition; speech, spatial, and qualities of hearing scale (SSQ-12).Of 745 (96.3%) patients qualifying for implantation, 642 (86.6%) pursued surgery. Median age at evaluation was 69 years; 56.3% were men; 88.2% were Caucasian. Median distance to our center was 95 miles. The majority (51.8%) had public insurance (Medicare, Medicaid), followed by private (47.8%) and military (0.4%). Mean PTA, CNC, and AzBio in quiet and noise for the ear to be implanted were 85.2 dB HL, 15.0%, and 19.2% and 3.5%, respectively. Hybrid/EAS criteria were met by 138 (18.5%) CI candidates, and 436 (77.0%) unilateral CI recipients had aidable contralateral hearing for bimodal hearing configurations. Younger age (odds ratio [OR], 0.96; 95% confidence interval, 0.93-0.99) and non-Caucasian race (OR, 6.95; 95% confidence interval, 3.22-14.98) predicted candidacy. Likelihood of surgery increased for Caucasian (OR, 8.08; 95% confidence interval, 4.85-13.47) and married (OR, 2.28; 95% confidence interval, 1.50-3.47) patients and decreased for those with public insurance (OR, 0.45; 95% confidence interval, 0.29-0.69). A lower SSQ-12 score predicted both candidacy and surgery.Despite expansions in criteria, speech understanding remained extremely low at CI evaluation. Younger age and non-Caucasian race predicted candidacy, and Caucasian, married patients with private insurance and lower SSQ scores were more likely to pursue surgery.

This study investigated the number of channels needed for maximum speech understanding and sound quality in 15 adult cochlear implant (CI) recipients with Advanced Bionics (AB) Mid-Scala electrode arrays completely within scala tympani. In experiment I, CI programs used a continuous interleaved sampling (CIS)-based strategy and 4–16 active electrodes. In experiment II, CI programs used an n-of- m strategy featuring 16 active electrodes with either 8- or 12-maxima. Speech understanding and sound quality measures were assessed. For CIS programs, participants demonstrated performance gains using up to 4–10 electrodes on speech measures and sound quality ratings. For n-of- m programs, there was no significant effect of maxima, suggesting 8-maxima is sufficient for this sample's maximum performance and sound quality. These results are largely consistent with previous studies using straight electrode arrays [e.g., Fishman, Shannon, and Slattery (1997). J. Speech Lang. Hear. Res. 40, 1201–1215; Friesen, Shannon, Baskent, and Wang (2001). J. Acoust. Soc. Am. 110, 1150–1163; Shannon, Cruz, and Galvin (2011). Audiol. Neurotol. 16, 113–123; Berg, Noble, Dawant, Dwyer, Labadie, and Gifford (2020). J. Acoust. Soc. Am. 147, 3646–3656] and in contrast with recent studies looking at cochlear precurved electrode arrays [e.g., Croghan, Duran, and Smith (2017). J. Acoust. Soc. Am. 142, EL537–EL543; Berg, Noble, Dawant, Dwuer, Labadie, and Gifford (2019b). J. Acoust. Soc. Am. 145, 1556-1564], which found continuous improvements up to 16 independent channels. These findings suggest that Mid-Scala electrode array recipients demonstrate similar channel independence to straight electrode arrays rather than other manufacturer's precurved electrode arrays.

Clinics are treating a growing number of patients with greater amounts of residual hearing. These patients often benefit from a bimodal hearing configuration in which acoustic input from a hearing aid on 1 ear is combined with electrical stimulation from a cochlear implant on the other ear. The current guidelines aim to review the literature and provide best practice recommendations for the evaluation and treatment of individuals with bilateral sensorineural hearing loss who may benefit from bimodal hearing configurations. Specifically, the guidelines review: benefits of bimodal listening, preoperative and postoperative cochlear implant evaluation and programming, bimodal hearing aid fitting, contralateral routing of signal considerations, bimodal treatment for tinnitus, and aural rehabilitation recommendations.

Objective To report the proportion of subjects successfully fit with combined electroacoustic stimulation (EAS) compared with those with preserved hearing (HP) after cochlear implantation (CI). In addition, to 1) report the trends in HP and EAS fit rates over time and 2) identify and characterize those patients who preferred the electric only condition. Study design Retrospective chart review. Setting Tertiary referral center. Patients Two hundred five postlingually deafened adults with bilateral SNHL and a preoperative low-frequency pure-tone average 80 dB HL or better in the ear to be implanted. Interventions Subjects underwent CI from 2013 to 2018 with routine pre- and postoperative audiometric testing performed at 6- and 12-months. Main outcome measures Percentage of patients fit with EAS, low-frequency pure-tone average, and threshold shift. Results Overall, 141 patients (78.6%) had HP at activation and 42.6% were fit with EAS. Rates of EAS fitting improved from 36.4% in 2013 to 69.0% in 2018. 93.5% of patients had hearing preserved in 2018 compared with 57.9% in 2013. Six patients rejected EAS after a trial period either because of discomfort or poor sound quality. Eight patients had EAS removed because of loss of aidable hearing over time (between activation to 12 mo). Conclusions Despite the high percentages of HP in the literature, EAS may be under-utilized in the adult CI population. Moving toward a universal definition of HP across institutions may better represent the potential for EAS fitting and a clinical measure capable of identifying patients best suited to benefit from EAS.

PurposeThe challenges associated with cochlear implant (CI)–mediated listening are well documented; however, they can be mitigated through the provision of aided acoustic hearing in the contralateral ear—a configuration termedbimodal hearing. This study extends previous literature to examine the effect of acoustic bandwidth in the non-CI ear for music perception. The primary aim was to determine the minimum and optimum acoustic bandwidth necessary to obtain bimodal benefit for music perception and speech perception.MethodParticipants included 12 adult bimodal listeners and 12 adult control listeners with normal hearing. Music perception was assessed via measures of timbre perception and subjective sound quality of real-world music samples. Speech perception was assessed via monosyllabic word recognition in quiet. Acoustic stimuli were presented to the non-CI ear in the following filter conditions: < 125, < 250, < 500, and < 750 Hz, and wideband (full bandwidth).ResultsGenerally, performance for all stimuli improved with increasing acoustic bandwidth; however, the bandwidth that is both minimally and optimally beneficial may be dependent upon stimulus type. On average, music sound quality required wideband amplification, whereas speech recognition with a male talker in quiet required a narrower acoustic bandwidth (< 250 Hz) for significant benefit. Still, average speech recognition performance continued to improve with increasing bandwidth.ConclusionFurther research is warranted to examine optimal acoustic bandwidth for additional stimulus types; however, these findings indicate that wideband amplification is most appropriate for speech and music perception in individuals with bimodal hearing.

This study investigated the number of channels available to cochlear implant (CI) recipients for maximum speech understanding and sound quality for lateral wall electrode arrays-which result in large electrode-to-modiolus distances-featuring the greatest inter-electrode distances (2.1-2.4 mm), the longest active lengths (23.1-26.4 mm), and the fewest number of electrodes commercially available. Participants included ten post-lingually deafened adult CI recipients with MED-EL electrode arrays (FLEX28 and STANDARD) entirely within scala tympani. Electrode placement and scalar location were determined using computerized tomography. The number of channels was varied from 4 to 12 with equal spatial distribution across the array. A continuous interleaved sampling-based strategy was used. Speech recognition, sound quality ratings, and a closed-set vowel recognition task were measured acutely for each electrode condition. Participants did not demonstrate statistically significant differences beyond eight channels at the group level for almost all measures. However, several listeners showed considerable improvements from 8 to 12 channels for speech and sound quality measures. These results suggest that channel interaction caused by the greater electrode-to-modiolus distances of straight electrode arrays could be partially compensated for by a large inter-electrode distance or spacing.

OBJECTIVE: 1) To complete a follow-up investigation of postoperative outcomes for adult cochlear implant (CI) recipients scoring ≥30% Consonant-Nucleus-Consonant (CNC) preoperatively, and 2) to describe the postoperative performance trajectory for this group of higher performing patients. STUDY DESIGN: Retrospective chart review. SETTING: Tertiary referral center. PATIENTS: One hundred four (105 ears) postlingually deafened adults who scored ≥30% CNC word recognition in the ear to be implanted preoperatively. INTERVENTIONS: One hundred four subjects underwent cochlear implantation. MAIN OUTCOME MEASURES: Pre- and postoperative CNC word scores and AzBio sentences in quiet and noise in the ear to be implanted as well as the bilateral-aided condition pre-CI and at 1, 3, 6, and 12 months post-CI. RESULTS: Statistically significant improvement was demonstrated for CNC and AzBio sentences in quiet and noise for the CI alone and bilateral listening conditions. Most improvement was demonstrated by 6-months postoperatively ( p < 0.001) with the exception of AzBio sentences in noise demonstrating improvement within 3 months ( p < 0.001). For patients with preop CNC scores up to 40% (n = 57), all recipients demonstrated either equivocal (n = 17) or statistically significant improvement (n = 40) for CNC word recognition in the CI-alone condition and none demonstrated a significant decrement in the bilateral condition. For patients with preop CNC scores >40% (n = 47, 48 ears), 89.3% (42 patients) demonstrated either equivocal (n = 24, 50%) or statistically significant improvement (n = 19, 39.6%) for CNC word recognition in the CI-only condition and none demonstrated a significant decrement in the bilateral condition. CONCLUSIONS: CI candidates with preoperative CNC word scores higher than conventional CI recipients derive statistically significant benefit from cochlear implantation for both the CI ear and best-aided condition. These data provide further support for the expansion of adult CI candidacy up to at least 40% CNC word recognition preoperatively with consideration given to further expansion possibly up to 60%.

Objectives There are no approved pharmacologic therapies for chronic sensorineural hearing loss (SNHL). The combination of CHIR99021+valproic acid (CV, FX-322) has been shown to regenerate mammalian cochlear hair cells ex vivo. The objectives were to characterize the cochlear pharmacokinetic profile of CV in guinea pigs, then measure FX-322 in human perilymph samples, and finally assess safety and audiometric effects of FX-322 in humans with chronic SNHL. Study designs Middle ear residence, cochlear distribution, and elimination profiles of FX-322 were assessed in guinea pigs. Human perilymph sampling following intratympanic FX-322 dosing was performed in an open-label study in cochlear implant subjects. Unilateral intratympanic FX-322 was assessed in a Phase 1b prospective, randomized, double-blinded, placebo-controlled clinical trial. Setting Three private otolaryngology practices in the US. Patients Individuals diagnosed with mild to moderately severe chronic SNHL (≤70 dB standard pure-tone average) in one or both ears that was stable for ≥6 months, medical histories consistent with noise-induced or idiopathic sudden SNHL, and no significant vestibular symptoms. Interventions Intratympanic FX-322. Main outcome measures Pharmacokinetics of FX-322 in perilymph and safety and audiometric effects. Results After intratympanic delivery in guinea pigs and humans, FX-322 levels in the cochlear extended high-frequency region were observed and projected to be pharmacologically active in humans. A single dose of FX-322 in SNHL subjects was well tolerated with mild, transient treatment-related adverse events (n = 15 FX-322 vs 8 placebo). Of the six patients treated with FX-322 who had baseline word recognition in quiet scores below 90%, four showed clinically meaningful improvements (absolute word recognition improved 18-42%, exceeding the 95% confidence interval determined by previously published criteria). No significant changes in placebo-injected ears were observed. At the group level, FX-322 subjects outperformed placebo group in word recognition in quiet when averaged across all time points, with a mean improvement from baseline of 18.9% (p = 0.029). For words in noise, the treated group showed a mean 1.3 dB signal-to-noise ratio improvement (p = 0.012) relative to their baseline scores while placebo-treated subjects did not (-0.21 dB, p = 0.71). Conclusions Delivery of FX-322 to the extended high-frequency region of the cochlea is well tolerated and enhances speech recognition performance in multiple subjects with stable chronic hearing loss.

Purpose This retrospective study used a cochlear implant registry to determine how performing speech recognition candidacy testing in quiet versus noise influenced patient selection, speech recognition, and self-report outcomes. Method Database queries identified 1,611 cochlear implant recipients who were divided into three implant candidacy qualifying groups based on preoperative speech perception scores (≤ 40% correct) on the AzBio sentence test: quiet qualifying group, +10 dB SNR qualifying group, and +5 dB SNR qualifying group. These groups were evaluated for demographic and preoperative hearing characteristics. Repeated-measures analysis of variance was used to compare pre- and postoperative performance on the AzBio in quiet and noise with qualifying group as a between-subjects factor. For a subset of recipients, pre- to postoperative changes on the Speech, Spatial and Qualities of Hearing Scale were also evaluated. Results Of the 1,611 patients identified as cochlear implant candidates, 63% of recipients qualified in quiet, 10% qualified in a +10 dB SNR, and 27% qualified in a +5 dB SNR. Postoperative speech perception scores in quiet and noise significantly improved for all qualifying groups. Across qualifying groups, the greatest speech perception improvements were observed when tested in the same qualifying listening condition. For a subset of patients, the total Speech, Spatial and Qualities of Hearing Scale ratings improved significantly as well. Conclusion Patients who qualified for cochlear implantation in quiet or background noise test conditions showed significant improvement in speech perception and quality of life scores, especially when the qualifying noise condition was used to track performance.

Individuals with severe to profound hearing loss are likely to present with complex listening needs that require evidence-based solutions. This document is intended to inform the practice of hearing care professionals who are involved in the audiological management of adults with a severe to profound degree of hearing loss and will highlight the special considerations and practices required to optimize outcomes for these individuals.

This study investigated the effects of cochlear implant (CI) electrode array type and scalar location on the number of channels available to CI recipients for maximum speech understanding and sound quality. Eighteen post-lingually deafened adult CI recipients participated, including 11 recipients with straight electrode arrays entirely in scala tympani and 7 recipients with translocated precurved electrode arrays. Computerized tomography was used to determine electrode placement and scalar location. In each condition, the number of channels varied from 4 to 22 with equal spatial distribution across the array. Speech recognition (monosyllables, sentences in quiet and in noise), subjective speech sound quality, and closed-set auditory tasks (vowels, consonants, and spectral modulation detection) were measured acutely. Recipients with well-placed straight electrode arrays and translocated precurved electrode arrays performed similarly, demonstrating asymptotic speech recognition scores with 8–10 channels, consistent with the classic literature. This finding contrasts with recent work [Berg, Noble, Dawant, Dwyer, Labadie, and Gifford. (2019). J. Acoust. Soc. Am. 145, 1556–1564] that found precurved electrode arrays well-placed in scala tympani demonstrate continuous performance gains beyond 8–10 channels. Given these results, straight and translocated precurved electrode arrays are theorized to have less channel independence secondary to their placement farther away from neural targets.

In 2020, the lower age limit for pediatric cochlear implant candidacy was lowered from 12 to 9 months of age. However, audiometric-based criteria for pediatric cochlear implant candidacy have remained unchanged for more than 20 years, requiring bilateral profound sensorineural hearing loss for children less than 2 years and bilateral severe-to-profound sensorineural hearing loss for children 2 years and older. Despite the static audiometric criteria, there is an increasing literature base demonstrating significant benefits for pediatric cochlear implant recipients who exceed current Food and Drug Administration-labeled indications for cochlear implantation.

Cochlear implantation with acoustic hearing preservation is becoming increasingly prevalent allowing cochlear implant (CI) users to combine electric and acoustic stimulation (EAS) in the implanted ears. Despite a growing EAS population, our field does not have definitive guidance regarding EAS technology optimization and the majority of previous studies investigating hearing aid (HA) and cochlear implant (CI) programming for EAS listeners have been mixed. Thus, the purpose of this exploratory study was to explore the effects of various EAS crossover frequencies-defined as the low-frequency (LF) CI cutoff-relative to the underlying spiral ganglion (SG) characteristic frequency associated with the most distal or apical electrode in the array. Speech recognition in semi-diffuse noise and subjective estimates of listening difficulty were measured for 15 adult CI recipients with acoustic hearing preservation in three listening conditions: 1) CI-alone, 2) bimodal (CI+HA), and best-aided EAS (CIHA+HA). The results showed no effect of LF CI cutoff for any of the three listening conditions such that there was no trend for increased performance or less subjective listening difficulty across LF CI cutoffs, referenced to underlying SG-place frequency. Consistent with past studies, the current results were also consistent with significant speech recognition and subject listening difficulty benefits for both bimodal (CI+HA) and best-aided EAS (CIHA+HA) as compared to CI-alone listening as well as significant additional benefits for best-aided EAS (CIHA+HA) compared to bimodal hearing (CI+HA). Future studies are necessary to investigate the efficacy of SG-place-based fittings for i) large samples of experienced EAS listeners for whom perceptual adaptation has occurred to the frequency mismatch provided by standard CI frequency allocations, and ii) EAS users at or close to CI activation as place-based approaches may ultimately yield greater outcomes, particularly for newly activated CI users for whom SG-place-based approaches may afford a steeper trajectory to performance asymptote.

Objective. The cochlear implant is a neural prosthesis designed to directly stimulate auditory nerve fibers to induce the sensation of hearing in those experiencing severe-to-profound hearing loss. After surgical implantation, audiologists program the implant’s external processor with settings intended to produce optimal hearing outcomes. The likelihood of achieving optimal outcomes increases when audiologists have access to tools that objectively present information related to the patient’s own anatomy and surgical outcomes. This includes visualizations like the one presented here, termed the activation region overlap image, which is designed to decrease subjectivity when determining amounts of overlapping stimulation between implant electrodes. Approach. This visualization uses estimates of electric field strength to indicate spread of neural excitation due to each electrode. Unlike prior visualizations, this method explicitly defines regions of nerves receiving substantial stimulation from each electrode to help clinicians assess the presence of significant overlapping stimulation. A multi-reviewer study compared this and an existing technique on the consistency, efficiency, and optimality of plans generated from each method. Statistical significance was evaluated using the two-sided Wilcoxon rank sum test. Main results. The study showed statistically significant improvements in consistency (p –12), efficiency (p −15), and optimality (p −5) when generating plans using the proposed method versus the existing method. Significance. This visualization addresses subjectivity in assessing overlapping stimulation between implant electrodes, which currently relies on reviewer estimates. The results of the evaluation indicate the provision of such objective information during programming sessions would likely benefit clinicians in making programming decisions.

This study investigated the number of channels required for asymptotic speech recognition for ten pediatric cochlear implant (CI) recipients with precurved electrode arrays. Programs with 4–22 active electrodes were used to assess word and sentence recognition in noise. Children demonstrated significant performance gains up to 12 electrodes for continuous interleaved sampling (CIS) and up to 22 channels with 16 maxima. These data are consistent with the latest adult CI studies demonstrating that modern CI recipients have access to more than 8 independent channels and that both adults and children exhibit performance gains up to 22 channels.

Purpose There is a growing body of literature that suggests a linkage between impaired auditory function, increased listening effort, and fatigue in children and adults with hearing loss. Research suggests this linkage may be associated with hearing loss–related variations in diurnal cortisol levels. Here, we examine variations in cortisol profiles between young adults with and without severe sensorineural hearing loss and examine associations between cortisol and subjective measures of listening effort and fatigue. Method This study used a repeated-measures, matched-pair design. Two groups ( n = 8 per group) of adults enrolled in audiology programs participated, 1 group of adults with hearing loss (AHL) and 1 matched control group without hearing loss. Salivary cortisol samples were collected at 7 time points over a 2-week period and used to quantify physiological stress. Subjective measures of listening effort, stress, and fatigue were also collected to investigate relationships between cortisol levels, perceived stress, and fatigue. Results Subjective ratings revealed that AHL required significantly more effort and concentration on typical auditory tasks than the control group. Likewise, complaints of listening-related fatigue were more frequent and more of a problem in everyday life for AHL compared to the control group. There was a significant association between subjective ratings of listening effort and listening-related fatigue for our AHL, but not for the control group. In contrast, there was no significant difference in cortisol measures between groups, nor were there significant associations between cortisol and any subjective measure. Conclusions Young AHL experience more effortful listening than their normal hearing peers. This increased effort is associated with increased reports of listening-related fatigue. However, diurnal cortisol profiles were not significantly different between groups nor were they associated with these perceived differences.

Objective The objectives of this study were to assess the effectiveness of various measures of speech understanding in distinguishing performance differences between adult bimodal and bilateral cochlear implant (CI) recipients and to provide a preliminary evidence-based tool guiding clinical decisions regarding bilateral CI candidacy. Design This study used a multiple-baseline, cross-sectional design investigating speech recognition performance for 85 experienced adult CI recipients (49 bimodal, 36 bilateral). Speech recognition was assessed in a standard clinical test environment with a single loudspeaker using the minimum speech test battery for adult CI recipients as well as with an R-SPACE 8-loudspeaker, sound-simulation system. All participants were tested in three listening conditions for each measure including each ear alone as well as in the bilateral/bimodal condition. In addition, we asked each bimodal listener to provide a yes/no answer to the question, "Do you think you need a second CI?" Results This study yielded three primary findings: (1) there were no significant differences between bimodal and bilateral CI performance or binaural summation on clinical measures of speech recognition, (2) an adaptive speech recognition task in the R-SPACE system revealed significant differences in performance and binaural summation between bimodal and bilateral CI users, with bilateral CI users achieving significantly better performance and greater summation, and (3) the patient's answer to the question, "Do you think you need a second CI?" held high sensitivity (100% hit rate) for identifying likely bilateral CI candidates and moderately high specificity (77% correct rejection rate) for correctly identifying listeners best suited with a bimodal hearing configuration. Conclusions Clinics cannot rely on current clinical measures of speech understanding, with a single loudspeaker, to determine bilateral CI candidacy for adult bimodal listeners nor to accurately document bilateral benefit relative to a previous bimodal hearing configuration. Speech recognition in a complex listening environment, such as R-SPACE, is a sensitive and appropriate measure for determining bilateral CI candidacy and also likely for documenting bilateral benefit relative to a previous bimodal configuration. In the absence of an available R-SPACE system, asking the patient whether or not s/he thinks s/he needs a second CI is a highly sensitive measure, which may prove clinically useful.

OBJECTIVE: The objective of this study was to investigate the effects of signal processing strategy on speech understanding and auditory function for adult cochlear implant (CI) users with a focus on the effects of sequential versus paired stimulation. DESIGN: Within-subjects, repeated measures design was utilised to compare performance between processing strategies and stimulation type on various measures of auditory function and subjective sound quality. Testing with subsequent strategies was completed after a total familiarisation time of two weeks. STUDY SAMPLE: Ten post-lingually deafened adult CI users were recruited from a clinical population. Participants had a minimum of 13 months CI experience. Ages ranged from 25–78 years. All participants had long-term experience with the optima strategy; eight with sequential stimulation and two with paired stimulation. RESULTS: We found no statistically significant effect of processing strategy. We observed an effect of stimulation type with sequential stimulation yielding significantly higher performance than paired stimulation for speech understanding in quiet and in noise, and subjective estimates of sound quality. No significant differences were noted across strategy or stimulation for music perception, spectral resolution or temporal resolution. CONCLUSIONS: Many patients utilise paired stimulation – the default stimulation type in the clinical software; however, sequential stimulation yielded significantly higher outcomes on multiple measures.

Preserved low-frequency acoustic hearing in cochlear implant (CI) recipients affords combined electric-acoustic stimulation (EAS) that could improve access to low-frequency acoustic binaural cues and enhance spatial hearing. Such benefits, however, could be undermined by interactions between electrical and acoustical inputs to adjacent (spectral overlap) or distant (binaural interference) cochlear places in EAS. This study simulated EAS in normal-hearing listeners, measuring interaural time difference (ITD) and interaural level difference (ILD) discrimination thresholds for a low-frequency noise (simulated acoustic target) in the presence or absence of a pulsatile high-frequency complex presented monotically or diotically (simulated unilateral or bilateral electric distractor). Unilateral distractors impaired thresholds for both cue types, suggesting influences of both binaural interference (which appeared more consistently for ITD than ILD) and physical spectral overlap (for both cue types). Reducing spectral overlap with an EAS gap between 1 and 3 kHz consistently improved binaural sensitivity. Finally, listeners displayed significantly lower thresholds with simulated bilateral versus unilateral electric stimulation. The combined effects revealed similar or better thresholds in bilateral full spectral overlap than in unilateral EAS gap conditions, suggesting that bilateral implantation with bilateral acoustic hearing preservation could allow for higher tolerance of spectral overlap in CI users and improved binaural sensitivity over unilateral EAS.

Individuals with bilateral cochlear implants (BiCIs) rely mostly on interaural level difference (ILD) cues to localize stationary sounds in the horizontal plane. Independent automatic gain control (AGC) in each device can distort this cue, resulting in poorer localization of stationary sound sources. However, little is known about how BiCI listeners perceive sound in motion. In this study, 12 BiCI listeners’ spatial hearing abilities were assessed for both static and dynamic listening conditions when the sound processors were synchronized by applying the same compression gain to both devices as a means to better preserve the original ILD cues. Stimuli consisted of band-pass filtered (100–8000 Hz) Gaussian noise presented at various locations or panned over an array of loudspeakers. In the static listening condition, the distance between two sequentially presented stimuli was adaptively varied to arrive at the minimum audible angle, the smallest spatial separation at which the listener can correctly determine whether the second sound was to the left or right of the first. In the dynamic listening condition, participants identified if a single stimulus moved to the left or to the right. Velocity was held constant and the distance the stimulus traveled was adjusted using an adaptive procedure to determine the minimum audible movement angle. Median minimum audible angle decreased from 17.1° to 15.3° with the AGC synchronized. Median minimum audible movement angle decreased from 100° to 25.5°. These findings were statistically significant and support the hypothesis that synchronizing the AGC better preserves ILD cues and results in improved spatial hearing abilities. However, restoration of the ILD cue alone was not enough to bridge the large performance gap between BiCI listeners and normal-hearing listeners on these static and dynamic spatial hearing measures.

Objective To create and validate a Spanish sentence test for evaluation of speech understanding of Spanish-speaking listeners with hearing loss or cochlear implants (CI). Study design Two thousand sentences were recorded from two male and two female speakers. The average intelligibility of each sentence was estimated as the mean score achieved by five listeners presented with a five-channel cochlear implant simulation. The mean scores of each sentence were used to construct 42 lists of 20 sentences with similar mean scores. List equivalency was then validated by presenting all lists to 10 CI users and in a 2-list comparison in a clinical setting to 38 CI patients. Setting Tertiary referral center. Patients Normal-hearing listeners (n = 5), CI users in a research study (n = 10), and CI patients (n = 38) in routine clinical follow-up. Intervention Multiple sentence lists from a newly minted speech perception test. Main outcome measures List intelligibility and equivalence across sentence lists. Results Forty-two lists of sentences were equivalent when all lists were presented in random order to 10 adult CI recipients. The variability of scores observed on lists presented to the same listener in the same condition was captured using a binomial distribution model based on a 40-item list for 38 adult implant recipients. Conclusion The Spanish AzBio Sentence Test includes 42 lists of 20 sentences. These sentences are roughly equivalent in terms of overall difficulty and confidence limits have been provided to assess the significance of variability in list scores observed within or across conditions. These materials will be of benefit when assessing native Spanish speakers in both research and clinical settings.

The reduction in spectral resolution by cochlear implants oftentimes requires complementary visual speech cues to aid in understanding. Despite substantial clinical characterization of auditory-only speech outcome measures, relatively little is known about the audiovisual integrative abilities that most cochlear implant (CI) users rely on for daily speech comprehension. In this study, we tested audiovisual integration in 63 CI users and 69 normal-hearing (NH) controls using the McGurk and sound-induced flash illusions. This study is the largest to-date measuring the McGurk effect in this population and the first to test the sound-induced flash illusion. When presented with conflicting audiovisual speech stimuli (i.e., the phoneme “ba” dubbed onto the viseme “ga”), we found that 55 CI users (87%) reported a fused percept of “da” or “tha” on at least one trial. However, overall, we found that CI users experienced the McGurk effect less often than controls—a result that was concordant with results with the sound-induced flash illusion where the pairing of a single circle flashing on the screen with multiple beeps resulted in fewer illusory flashes for CI users. While illusion perception in these two tasks appears to be uncorrelated among CI users, we identified a negative correlation in the NH group. Because neither illusion appears to provide further explanation of variability in CI outcome measures, further research is needed to determine how these findings relate to CI users’ speech understanding, particularly in ecological listening conditions that are naturally multisensory.

Purpose Electric and acoustic stimulation (EAS) with preserved hearing in the implanted ear provides benefit for speech understanding, spatial hearing, and quality of life in adults. However, there is limited research on EAS outcomes in children. The aims of this study were to estimate the magnitude of EAS-related benefit on speech understanding in children with preserved acoustic hearing and to determine what role acoustic interaural time difference (ITD) sensitivity may have on said EAS benefit. Methods Six children with acoustic hearing preservation and 20 children with normal hearing (NH) were recruited to participate. Speech recognition was assessed via an eight-loudspeaker array with speech presented from one loudspeaker at 0 degree and restaurant noise from all other loudspeakers (45-315 degrees). ITD thresholds were measured for a 250-Hz signal presented acoustically via insert earphones. Results Only one EAS listener demonstrated significant benefit from bilateral acoustic hearing as compared with acoustic hearing from a single ear. ITD thresholds were poor in the range of 302 to 1000+ ms and were considerably poorer than ITD thresholds for the NH group. Conclusion These data suggest that children with acoustic hearing preservation may not exhibit initial EAS benefit for speech recognition in semi-diffuse noise; however, because none exhibited a decrement in performance with bilateral acoustic stimulation, EAS fittings are recommended to provide binaural acoustic access allowing for EAS adaptation to binaural cues over time. Future research should address the emergence of EAS benefit, binaural cue sensitivity, and the role of EAS experience in children and adults.

Objective Encourage adaptation of a standardized format for reporting hearing preservation outcomes in cochlear implantation (CI). Study design Retrospective chart review. Setting Tertiary referral center. Patients One hundred seventy-eight postlingually deafened adults with bilateral SNHL and a preoperative low-frequency pure-tone average (LFPTA) 80 dB HL or better at 125, 250, and 500 Hz in the ear to be implanted. Interventions Subjects underwent unilateral CI from 2013 to 2019 at a large referral center. Pre- versus postoperative LPFTA was used to generate a scattergram. Main outcomes measures Pre- versus postoperative activation LPFTA, percentage of patients fit with electric and acoustic stimulation, scattergram plot. Results Average postoperative LFPTA was 68.6 dB HL (range 18-68) compared with 48.7 dB (range 5-80), preoperatively. At activation, the average LFPTA shift at CI activation was 20.5 dB HL (range 0-60) and 83.5% (n = 137) patients had hearing preserved, of whom 41.6% were fit with electric and acoustic stimulation throughout the study period. The scattergram successfully illustrates the distribution and number of patients with their respective audiometric outcomes. Conclusions The scattergram developed for reporting hearing outcomes in clinical trials is highly adaptable to reporting hearing preservation results in cochlear implant surgery. It represents a transparent and accessible option for reporting outcomes that can be used as a consistent format to allow for interstudy comparison and future meta-analysis.

Cochlear implants consist of an implanted array of electrodes and passive electronics and an external processor designed to directly stimulate auditory nerve fibers to induce the sensation of hearing in those who have experienced hearing loss caused by problems in the inner ear. After surgical implantation, audiologists program the processor with settings intended to produce optimal hearing outcomes. The likelihood of optimal outcomes increases when audiologists are provided with tools that assist them in making objective decisions based on the patient’s own anatomy and surgical placement of the array. A visualization tool currently in use, called distance-versus-frequency (DVF)curves, can be used to estimate channel interactions between electrodes. Although the information presented is objective, an audiologist’s decisions are subject to their own estimations applied to this visualization. In this paper, we present a new visualization technique designed to remove the subjectivity of visually assessing channel interactions between electrodes. Preliminary results show plans generated using this method are more consistent and are rated as optimal more often than those generated using DVF curves.

BACKGROUND: Mutations in the TMPRSS3 gene, although rare, can cause high frequency hearing loss with residual hearing at low frequencies. Several previous studies have reported cochlear implant (CI) outcomes for adults with TMPRSS3 mutation with mixed results. Although some studies have suggested that TMPRSS3 is expressed in spiral ganglion cells, it remains unclear if previously reported poor CI outcomes in this population were secondary to long durations of deafness or to the effects of the TMPRSS3 mutation. To date, no studies in the literature have reported CI outcomes for children with TMPRSS3 mutation treated with CI. OBJECTIVE: The current case series aimed to describe outcomes for three children with sloping hearing loss caused by TMPRSS3 mutation who underwent bilateral CI. STUDY DESIGN: Case series. SETTING: Academic medical center. PATIENTS: Three children (3–4 yr) with TMPRSS3 mutation and normal sloping to profound high frequency hearing loss. INTERVENTIONS: CI and electric acoustic stimulation (EAS). MAIN OUTCOME MEASURES: Outcome measures were residual hearing thresholds, speech recognition scores, and electrode placement determined via intraoperative CT imaging. RESULTS: All three children maintained residual acoustic hearing and received benefit from EAS. Mean change in low-frequency pure-tone average was 17 dB. Mean postoperative word and sentence recognition scores in the bilateral EAS condition were 80 and 75%, respectively. CONCLUSIONS: Results indicate that CI with EAS is an appropriate treatment for children with TMPRSS3 genetic mutation. Pediatric results from this case series show more favorable CI outcomes than are currently reported for adults with TMPRSS3 mutation suggesting that the intervention may be time sensitive.

Purpose Spatially separating speech and background noise improves speech understanding in normal-hearing listeners, an effect referred to as spatial release from masking (SRM). In cochlear implant (CI) users, SRM has often been demonstrated using asymmetric noise configurations, which maximize benefit from head shadow and the potential availability of binaural cues. In contrast, SRM in symmetrical configurations has been minimal to absent in CI users. We examined the interaction between two types of maskers (informational and energetic) and SRM in bimodal and bilateral CI users. We hypothesized that SRM would be absent or “negative” using symmetrically separated noise maskers. Second, we hypothesized that bimodal listeners would exhibit greater release from informational masking due to access to acoustic information in the non-CI ear. Method Participants included 10 bimodal and 10 bilateral CI users. Speech understanding in noise was tested in 24 conditions: 3 spatial configurations (S 0 N 0 , S 0 N 45&315 , S 0 N 90&270 ) × 2 masker types (speech, signal-correlated noise) × 2 listening configurations (best-aided, CI-alone) × 2 talker gender conditions (different-gender, same-gender). Results In support of our first hypothesis, both groups exhibited negative SRM with increasing spatial separation. In opposition to our second hypothesis, both groups exhibited similar magnitudes of release from informational masking. The magnitude of release was greater for bimodal listeners, though this difference failed to reach statistical significance. Conclusions Both bimodal and bilateral CI recipients exhibited negative SRM. This finding is consistent with CI signal processing limitations, the audiologic factors associated with SRM, and known effects of behind-the-ear microphone technology. Though release from informational masking was not significantly different across groups, the magnitude of release was greater for bimodal listeners. This suggests that bimodal listeners may be at least marginally more susceptible to informational masking than bilateral CI users, though further research is warranted.

PURPOSE OF REVIEW: This review describes speech perception and language outcomes for children using bimodal hearing (cochlear implant (CI) plus contralateral hearing aid) as compared to children with bilateral CIs and contrasts said findings with the adult literature. There is a lack of clinical evidence driving recommendations for bimodal versus bilateral CI candidacy and as such, clinicians are often unsure about when to recommend a second CI for children with residual acoustic hearing. Thus the goal of this review is to identify scientific information that may influence clinical decision making for pediatric CI candidates with residual acoustic hearing. RECENT FINDINGS: Bilateral CIs are considered standard of care for children with bilateral severe-to-profound sensorineural hearing loss. For children with aidable acoustic hearing—even in just the low frequencies—an early period of bimodal stimulation has been associated with significantly better speech perception, vocabulary, and language development. HA audibility, however, is generally poorer than that offered by a CI resulting in interaural asymmetry in speech perception, head shadow, as well as brainstem and cortical activity and development. Thus there is a need to optimize “two-eared” hearing while maximizing a child’s potential with respect to hearing, speech, and language while ensuring that we limit asymmetrically driven auditory neuroplasticity. A recent large study of bimodal and bilateral CI users suggested that a period of bimodal stimulation was only beneficial for children with a better-ear pure tone average (PTA) ≤ 73 dB HL. This 73-dB-HL cutoff applied even to children who ultimately received bilateral CIs. SUMMARY: Though we do not yet have definitive guidelines for determining bimodal versus bilateral CI candidacy, there is increasing evidence that 1) bilateral CIs yield superior outcomes for children with bilateral severe-to-profound hearing loss and, 2) an early period of bimodal stimulation is beneficial for speech perception and language development, but only for children with better-ear PTA ≤ 73 dB HL. For children with residual acoustic hearing, even in just the low-frequency range, rapid sequential bilateral cochlear implantation following a trial period with bimodal stimulation will yield best outcomes for auditory, language, and academic development. Of course, there is also an increasing prevalence of cochlear implantation with acoustic hearing preservation allowing for combined electric and acoustic stimulation even following bilateral implantation.

International audience; Importance Cochlear implants are a treatment option for individuals with severe, profound, or moderate sloping to profound bilateral sensorineural hearing loss (SNHL) who receive little or no benefit from hearing aids; however, cochlear implantation in adults is still not routine.Objective To develop consensus statements regarding the use of unilateral cochlear implants in adults with severe, profound, or moderate sloping to profound bilateral SNHL.Design, Setting, and Participants This study was a modified Delphi consensus process that was informed by a systematic review of the literature and clinical expertise. Searches were conducted in the following databases: (1) MEDLINE In-Process & Other Non-Indexed Citations and Ovid MEDLINE, (2) Embase, and (3) the Cochrane Library. Consensus statements on cochlear implantation were developed using the evidence identified. This consensus process was relevant for the use of unilateral cochlear implantation in adults with severe, profound, or moderate sloping to profound bilateral SNHL. The literature searches were conducted on July 18, 2018, and the 3-step Delphi consensus method took place over the subsequent 9-month period up to March 30, 2019.Main Outcomes and Measures A Delphi consensus panel of 30 international specialists voted on consensus statements about cochlear implantation, informed by an SR of the literature and clinical expertise. This vote resulted in 20 evidence-based consensus statements that are in line with clinical experience. A modified 3-step Delphi consensus method was used to vote on and refine the consensus statements. This method consisted of 2 rounds of email questionnaires and a face-to-face meeting of panel members at the final round. All consensus statements were reviewed, discussed, and finalized at the face-to-face meeting.Results In total, 6492 articles were identified in the searches of the electronic databases. After removal of duplicate articles, 74 articles fulfilled all of the inclusion criteria and were used to create the 20 evidence-based consensus statements. These 20 consensus statements on the use of unilateral cochlear implantation in adults with SNHL were relevant to the following 7 key areas of interest: level of awareness of cochlear implantation (1 consensus statement); best practice clinical pathway from diagnosis to surgery (3 consensus statements); best practice guidelines for surgery (2 consensus statements); clinical effectiveness of cochlear implantation (4 consensus statements); factors associated with postimplantation outcomes (4 consensus statements); association between hearing loss and depression, cognition, and dementia (5 consensus statements); and cost implications of cochlear implantation (1 consensus statement).Conclusions and Relevance These consensus statements represent the first step toward the development of international guidelines on best practices for cochlear implantation in adults with SNHL. Further research to develop consensus statements for unilateral cochlear implantation in children, bilateral cochlear implantation, combined electric-acoustic stimulation, unilateral cochlear implantation for single-sided deafness, and asymmetrical hearing loss in children and adults may be beneficial for optimizing hearing and quality of life for these patients.

Background Microphone location has been shown to influence speech recognition with a microphone placed at the entrance to the ear canal yielding higher levels of speech recognition than top-of-the-pinna placement. Although this work is currently influencing cochlear implant programming practices, prior studies were completed with previous-generation microphone and sound processor technology. Consequently, the applicability of prior studies to current clinical practice is unclear.Purpose To investigate how microphone location (e.g., at the entrance to the ear canal, at the top of the pinna), speech-source location, and configuration (e.g., omnidirectional, directional) influence speech recognition for adult CI recipients with the latest in sound processor technology.Research Design Single-center prospective study using a within-subjects, repeated-measures design.Study Sample Eleven experienced adult Advanced Bionics cochlear implant recipients (five bilateral, six bimodal) using a Naída CI Q90 sound processor were recruited for this study.Data Collection and Analysis Sentences were presented from a single loudspeaker at 65 dBA for source azimuths of 0°, 90°, or 270° with semidiffuse noise originating from the remaining loudspeakers in the R-SPACE array. Individualized signal-to-noise ratios were determined to obtain 50% correct in the unilateral cochlear implant condition with the signal at 0°. Performance was compared across the following microphone sources: T-Mic 2, integrated processor microphone (formerly behind-the-ear mic), processor microphone + T-Mic 2, and two types of beamforming: monaural, adaptive beamforming (UltraZoom) and binaural beamforming (StereoZoom). Repeated-measures analyses were completed for both speech recognition and microphone output for each microphone location and configuration as well as sound source location. A two-way analysis of variance using mic and azimuth as the independent variables and output for pink noise as the dependent variable was used to characterize the acoustic output characteristics of each microphone source.Results No significant differences in speech recognition across omnidirectional mic location at any source azimuth or listening condition were observed. Secondary findings were (1) omnidirectional microphone configurations afforded significantly higher speech recognition for conditions in which speech was directed to ± 90° (when compared with directional microphone configurations), (2) omnidirectional microphone output was significantly greater when the signal was presented off-axis, and (3) processor microphone output was significantly greater than T-Mic 2 when the sound originated from 0°, which contributed to better aided detection at 2 and 6 kHz with the processor microphone in this group.Conclusions Unlike previous-generation microphones, we found no statistically significant effect of microphone location on speech recognition in noise from any source azimuth. Directional microphones significantly improved speech recognition in the most difficult listening environments.

BACKGROUND: Despite improvements in cochlear implant (CI) technology, pediatric CI recipients continue to have more difficulty understanding speech than their typically hearing peers in background noise. A variety of strategies have been evaluated to help mitigate this disparity, such as signal processing, remote microphone technology, and microphone placement. Previous studies regarding microphone placement used speech processors that are now dated, and most studies investigating the improvement of speech recognition in background noise included adult listeners only. PURPOSE: The purpose of the present study was to investigate the effects of microphone location and beamforming technology on speech understanding for pediatric CI recipients in noise. RESEARCH DESIGN: A prospective, repeated-measures, within-participant design was used to compare performance across listening conditions. STUDY SAMPLE: A total of nine children (aged 6.6 to 15.3 years) with at least one Advanced Bionics CI were recruited for this study. DATA COLLECTION AND ANALYSIS: The Basic English Lexicon Sentences and AzBio Sentences were presented at 0° azimuth at 65-dB SPL in +5 signal-to-noise ratio noise presented from seven speakers using the R-SPACE system (Advanced Bionics, Valencia, CA). Performance was compared across three omnidirectional microphone configurations (processor microphone, T-Mic 2, and processor + T-Mic 2) and two directional microphone configurations (UltraZoom and auto UltraZoom). The two youngest participants were not tested in the directional microphone configurations. RESULTS: No significant differences were found between the various omnidirectional microphone configurations. UltraZoom provided significant benefit over all omnidirectional microphone configurations (T-Mic 2, p = 0.004, processor microphone, p < 0.001, and processor microphone + T-Mic 2, p = 0.018) but was not significantly different from auto UltraZoom (p = 0.176). CONCLUSIONS: All omnidirectional microphone configurations yielded similar performance, suggesting that a child’s listening performance in noise will not be compromised by choosing the microphone configuration best suited for the child. UltraZoom (adaptive beamformer) yielded higher performance than all omnidirectional microphones in moderate background noise for adolescents aged 9 to 15 years. The implications of these data suggest that for older children who are able to reliably use manual controls, UltraZoom will yield significantly higher performance in background noise when the target is in front of the listener.

Several cues are used to convey musical emotion, the two primary being musical mode and musical tempo. Specifically, major and minor modes tend to be associated with positive and negative valence, respectively, and songs at fast tempi have been associated with more positive valence compared to songs at slow tempi (Balkwill and Thompson, 1999; Webster and Weir, 2005). In Experiment I, we examined the relative weighting of musical tempo and musical mode among adult cochlear implant (CI) users combining electric and contralateral acoustic stimulation, or “bimodal” hearing. Our primary hypothesis was that bimodal listeners would utilize both tempo and mode cues in their musical emotion judgments in a manner similar to normal-hearing listeners. Our secondary hypothesis was that low-frequency (LF) spectral resolution in the non-implanted ear, as quantified via psychophysical tuning curves (PTCs) at 262 and 440 Hz, would be significantly correlated with degree of bimodal benefit for musical emotion perception. In Experiment II, we investigated across-channel spectral resolution using a spectral modulation detection (SMD) task and neural representation of temporal fine structure via the frequency following response (FFR) for a 170-ms /da/ stimulus. Results indicate that CI-alone performance was driven almost exclusively by tempo cues, whereas bimodal listening demonstrated use of both tempo and mode. Additionally, bimodal benefit for musical emotion perception may be correlated with spectral resolution in the non-implanted ear via SMD, as well as neural representation of F0 amplitude via FFR – though further study with a larger sample size is warranted. Thus, contralateral acoustic hearing can offer significant benefit for musical emotion perception, and the degree of benefit may be dependent upon spectral resolution of the non-implanted ear.

Objectives This systematic review is designed to (a) describe measures used to quantify vocal development in pediatric cochlear implant (CI) users, (b) synthesize the evidence on prelinguistic vocal development in young children before and after cochlear implantation, and (c) analyze the application of the current evidence for evaluating change in vocal development before and after cochlear implantation for young children. Investigations of prelinguistic vocal development after cochlear implantation are only beginning to uncover the expected course of prelinguistic vocal development in children with CIs and what factors influence that course, which varies substantially across pediatric CI users. A deeper understanding of prelinguistic vocal development will improve professionals' abilities to determine whether a child with a CI is exhibiting sufficient progress soon after implantation and to adjust intervention as needed. Design We systematically searched PubMed, ProQuest, and CINAHL databases for primary reports of children who received a CI before 5 years 0 months of age that included at least one measure of nonword, nonvegetative vocalizations. We also completed supplementary searches. Results Of the 1916 identified records, 59 met inclusion criteria. The included records included 1125 total participants, which came from 36 unique samples. Records included a median of 8 participants and rarely included children with disabilities other than hearing loss. Nearly all of the records met criteria for level 3 for quality of evidence on a scale of 1 (highest) to 4 (lowest). Records utilized a wide variety of vocalization measures but often incorporated features related to canonical babbling. The limited evidence from pediatric CI candidates before implantation suggests that they are likely to exhibit deficits in canonical syllables, a critical vocal development skill, and phonetic inventory size. Following cochlear implantation, multiple studies report similar patterns of growth, but faster rates producing canonical syllables in children with CIs than peers with comparable durations of robust hearing. However, caution is warranted because these demonstrated vocal development skills still occur at older chronological ages for children with CIs than chronological age peers with typical hearing. Conclusions Despite including a relatively large number of records, the evidence in this review regarding changes in vocal development before and after cochlear implantation in young children remains limited. A deeper understanding of when prelinguistic skills are expected to develop, factors that explain deviation from that course, and the long-term impacts of variations in vocal prelinguistic development is needed. The diverse and dynamic nature of the relatively small population of pediatric CI users as well as relatively new vocal development measures present challenges for documenting and predicting vocal development in pediatric CI users before and after cochlear implantation. Synthesizing results across multiple institutions and completing rigorous studies with theoretically motivated, falsifiable research questions will address a number of challenges for understanding prelinguistic vocal development in children with CIs and its relations with other current and future skills. Clinical implications include the need to measure prelinguistic vocalizations regularly and systematically to inform intervention planning.

OBJECTIVE Quantify the relationship between average hours of processor use per day and measures of speech recognition in post-lingually deafened adults with cochlear implants. SETTING Cochlear implant (CI) program at a tertiary medical center. PATIENTS Three hundred adult (mean age = 64, 130 women) CI users were included. MAIN OUTCOME MEASURES Correlation analyses were completed for CI-aided speech recognition (Consonant-Nucleus-Consonant [CNC] monosyllables and AzBio sentences) at approximately 12 months post-implantation and average hours of processor use per day, which was extracted from the CI programming software. RESULTS Average processor use was 10.2 hours per day (range, 0.1-22.7), and average speech recognition scores were 49.9 and 61.7% for CNC and AzBio sentence recognition, respectively. We found a strong, significant correlation between hours of processor use per day and consonant-nucleus-consonant (CNC) word recognition (rs = 0.61, p