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How does competence (specifically, vocational competence and social competence) affect the chance of a new graduate who discloses his impairment to enter the job market, compared to his counterpart who does not disclose his impairment? To answer this question, we adopt a resume-based experimental audit study, in which we use an artificial application package (CV & cover letter) to apply for real jobs.

In the Netherlands demands on IT support in healthcare organizations are increasing. New visions on healthcare focus on patient-centered healthcare, where mutual consultation among healthcare professionals in the network becomes a standard process. Recent governmental regulations prescribe that patients must be able to access personal health records. IT flexibility is needed to allow organizations to meet new demands. In this study, we focus on Conceptual Independence (CI) be-cause CI, as a design principle, can improve the adaptability of Information Systems (IS). Software with CI operates on flexible data models that are independent of the CI based application. Therefore, it is claimed that a standalone IS becomes more flexible with CI. We extend the claim by demonstrating that CI affects the flexibility of the entire IT infrastructure. We investigate which dimensions of IT flexibility are responsible for the improvement. Multi-case study research has been performed following a mixed-methods approach in 10 mental healthcare organizations. Five have implemented openEHR, a proxy for CI, and five have not. Data has been collected with a questionnaire of IT infrastructure flexibility and semi-structured interviews. The data synthesis shows a positive effect of CI on IT flexibility, as CI increases the adaptability of IS, transparency and standardization of the IT infrastructure. Mean scores of openEHR organizations and other organizations on the questionnaire of IT infrastructure flexibility Mean scores of openEHR organizations and other organizations on the questionnaire of IT infrastructure flexibility … Reuse and modularity P2: Reuse of functionality increases Modularity of IT infrastructure Reuse and modularity P2: Reuse of functionality increases Modularity of IT infrastructure … Accessibility of data Accessibility of data … Mean Scores for Organizations on IT Infrastructure Flexibility Questionnaire Mean Scores for Organizations on IT Infrastructure Flexibility Questionnaire … Hypothesis Test Summary -Means Hypothesis Test Summary -Means … Figures - uploaded by Rogier van de WeteringAuthor content Content may be subject to copyright.

Mixed reality applications can enrich museum exhibits and make them more attractive to an audience of adolescents. However, in the design of such applications, we face a myriad of possibilities and little guidance on how to choose between (early) alternatives. In this paper, we explore the notion of experience blend -which could act as an aesthetic governing the design of mixed reality experiences. We present an effort to operationalize experience blend and illustrate its use in the design and evaluation of an application for an art museum. Stakeholders in the project assumed that in order to reach out to adolescents an exciting experience was needed, deviating from education and breaking with the hidden rules of the art-museum, our user study showed that adolescents favored a blended experience. This suggests experience blend may be a helpful aesthetic in the design of other mixed reality experiences.

Recently, a monolithic scintillator detector for time-of-flight (TOF)/depth-of-interaction (DOI) positron emission tomography (PET) was developed. It has a detector spatial resolution of ∼1.7 mm full-width-at-half-maximum (FWHM), a coincidence resolving time (CRT) of ∼215 ps FWHM, and ∼4.7 mm FWHM DOI resolution. Here, we demonstrate, for the first time, the imaging performance of this detector in a 70 cm diameter PET geometry. We built a tomographic setup representative of a whole-body clinical scanner, comprising two coaxially rotating arms, each carrying a detector module, and a central, rotating phantom table. The fully automated setup sequentially acquires all possible lines of response (LORs) of a complete detector ring, using a step-and-shoot acquisition approach. The modules contained 2 × 2 detectors, each detector consisting of a 32 mm × 32 mm × 22 mm LYSO crystal and a digital silicon photomultiplier (dSiPM) array. The system spatial resolution was assessed using a Na-22 point source at different radial distances in the field-of-view (FOV). Using 2D filtered back projection (2D FBP, non-TOF), tangential and radial spatial resolutions of ∼2.9 mm FWHM were obtained at the center of the FOV. The use of DOI information resulted in almost uniform spatial resolution throughout the FOV up to a radial distance of 25 cm, where the radial and tangential resolution are ∼3.3 mm FWHM and ∼4.7 mm FWHM, respectively, whereas without DOI the resolution deteriorates to ∼9 mm FWHM. Additional measurements were performed with a Na-22 filled Derenzo-like phantom at different locations within the FOV. Images reconstructed with a TOF maximum-likelihood expectation-maximization (TOF ML-EM) algorithm show that the system is able to clearly resolve 3 mm diameter hot rods up to 25 cm radial distance. The excellent and uniform spatial resolution, combined with an energy resolution of 10.2% FWHM and a CRT of ∼212 ps FWHM, indicates a great potential for monolithic scintillators as practical high-performance detectors in TOF/DOI-PET systems.

This paper applies and discusses the principles of Axiomatic Design for changing IT architecture in health care. It presents three case studies positioned in the field of Enterprise architecture that explore how IT architects, as professionals, manage change and re-design the structure of the IT systems in line with strategic goals. The research approach was to use a light modelling tool, Ampersand, for modelling the Enterprise architecture. Two types of models stand out: Type 1 Strategic IT models in which higher strategic goals are related to requirements for applications and Type 2 Technical management of systems models in which technical risks and risk of system failure in the current IT infrastructure were modelled. To bridge the views of different IT experts in the organization this work uses the customer domain, the functional domain and the physical domain from Axiomatic Design in an extended example in the paper. The V Model is used to bridge the models, and then it is extended with Axiomatic Design principles.

In this paper we explain why Axiomatic design has not been applied in large system of systems information technology architectures in health care organizations in the Netherlands. We have found in extensive case studies of IT systems that the Independence axiom could not be found in the existing Information systems. This causes great concern for the adaptability of systems. Although best practices in system engineering advice decoupling of system functionality, findings show that the Independence Axiom has not been applied to functional requirements. A number of difficulties was exposed to the researcher and IT architects, when they tried to identify and to demarcate functional requirements in existing systems. In IT systems a distinction is made between business and system functions and software engineers emphasize decoupling of system functions. That has resulted in a strong coupling of business information and technical application logic. This means Conceptual dependencies are often at the heart of the difficulties. Decoupling these dependencies in applications seems a candidate for ordering requirements in a way that keeps the functional requirements independent from each other. Conceptual independence signifies a complete decoupling of the concepts and relations of the Business domain from the technical functionality. The paper describes the difficulties when applying the Independence Axiom in the Information systems domain and argues that a combination of Conceptual independence and Axiomatic design is achievable. The authors adapt the Design matrix with Conceptual independence. We conclude that applying Conceptual independence is crucial when constructing IT systems based on Axiomatic design. Components in Home care institute. Components in Home care institute. … . Descriptions of DPs. . Descriptions of DPs. … Figures - available via license: Creative Commons Attribution 4.0 International Content may be subject to copyright.

PROBLEM: Little is known about effective nursing interventions for adolescents with anorexia nervosa. The purpose of this study was to discover which aspects of nursing care are most effective, according to nurses, in recovery of normal body weight in adolescents with anorexia nervosa. METHODS: A qualitative descriptive research design was applied with individual in-depth interviews and a focus group. Thematic analysis was used to analyze the data. FINDINGS: Nurses state that they are in a key position in guiding patients with anorexia nervosa toward a path of weight recovery. A good therapeutic relationship is essential to the implementation of targeted nursing interventions in the areas of eating and exercising, social support, and parent counseling. CONCLUSIONS: The results of this research can be used to define more detailed nursing interventions, the effectiveness of which can be tested in follow-up research.

The paper describes a systematic approach to support the redesign process. Redesign is the adaptation of a technical system in order to meet new specifications. The approach presented is based on techniques developed in model-based diagnosis research. The essence of the approach is to find the part of the system which causes the discrepancy between a formal specification of the system to be designed and the description of the existing technical system. Furthermore, new specifications are generated, describing the new behaviour for the `faulty¿ part. These specifications guide the actual design of this part. Both the specification and design description are based on YMIR, an ontology for structuring engineering design knowledge.

We previously investigated the primary and secondary responses and hyperimmunization to the T cell-dependent antigen 2,4-dinitrophenyl keyhole limpet hemocyanin (DNP-KLH) in antigen-free (AF), germ-free (GF) and conventional (CV) mice. Both the absolute and relative numbers of DNP-specific IgG-secreting cells in the spleen of AF mice were considerably higher compared to GF and CV mice, especially after hyperimmunization. In the present study we measured the total and DNP-specific IgG concentration in the sera of these hyperimmunized mice using a sensitive sandwich enzyme-linked immunosorbent assay. With respect to the total IgG concentration before and after hyperimmunization, the AF mice showed an almost 13-fold increase after boosting with the antigen; the GF mice showed an approximately 8-fold increase. A slight but non-significant increase was observed in the CV mice. The total as well as the DNP-specific IgG levels in the AF-immunized mice were 2-fold and 5-fold higher compared to GF and CV mice, respectively. With the use of Surface Plasmon Resonance instrumentation (BIAcore(TM), Pharmacia, Uppsala, Sweden) we obtained mean binding affinities (K-A) of the polyclonal samples of the three groups of hyperimmunized mice. IgA and IgM samples displayed low affinity for DNP-lysine. The AF mice displayed the highest K-A value among IgG antibodies, followed by GF mice, while CV mice showed a 3-fold lower K-A compared to AF mice. These differences were mainly determined by the dissociation rate constant (k(diss)), since no significant changes were observed in the association rate constant (k(ass)). Furthermore, the sera of the CV mice have a lower percentage of high-affinity antibodies compared to GF and AF mice. These results suggest that besides a higher overall binding affinity seen in AF mice, and to a lesser extent in GF mice, the relative contribution of high-affinity IgG is greater in AF mice compared to CV mice.

One of the main problems in the field of model-based diagnosis of technical systems today is finding the most useful model or models of the system being diagnosed. Often, a model showing the physical components and the connections between them is all that is available. As systems grow larger and larger, the run-time performance of diagnostic algorithms decreases considerably when using these detailed models. A solution to this problem is using a hierarchic model. This allows us to first diagnose the system using an abstract model, and then use this solution to guide the diagnostic process using a more detailed model. The main problem with this approach is acquiring the hierarchic model. We give a generic hierarchic diagnostic algorithm and show how the use of certain classes of hierarchic models can increase the performance of this algorithm. We then present linear time algorithms for the automatic construction of these hierarchic models, using the detailed model and extra information about cost of probing points and invertibility of components.

Little is known about effective nursing interventions for adolescents with anorexia nervosa. The purpose of this study was to discover which aspects of nursing care are most effective, according to nurses, in recovery of normal body weight in adolescents with anorexia nervosa. A qualitative descriptive research design was applied with individual in-depth interviews and a focus group. Thematic analysis was used to analyze the data. Nurses state that they are in a key position in guiding patients with anorexia nervosa toward a path of weight recovery. A good therapeutic relationship is essential to the implementation of targeted nursing interventions in the areas of eating and exercising, social support, and parent counseling. The results of this research can be used to define more detailed nursing interventions, the effectiveness of which can be tested in follow-up research.

The model-based diagnosis project at the University of Twente has been directed at improving the practical usefulness of model-based diagnosis. In cooperation with industrial partners, the research addressed the modeling problem and the efficiency problem in model-based reasoning. Main results of this research are that (1) re-use of electronically available descriptions of systems for diagnostic purposes is possible, and (2) efficient reasoning can be realized using PDE, hierarchic models, and a simple diagnostic strategy. We have built a prototype diagnostic system which shows the technical feasibility of model-based diagnosis in a computer system. The project was concluded in July 1993 by the development of the `Diagnostic Toolbox?. The Diagnostic Toolbox supports the modeling of technical systems for diagnostic purposes, and it contains several model-based reasoning methods.

Model-based diagnosis (MBD) is a technique to locate faults in a system with the aid of a model of that system. The model describes the correct behavior of the system, and possibly also the behavior in case of a fault. In the field of model-based diagnosis, most attention has been given to the problem of reasoning: how to derive diagnoses, given a model. When applying MBD in practice, modeling appears to be a problem of equal magnitude. In this paper, we analyze the modeling process, and show how design information can be used in this process. We investigated the use of information in two standard languages for information interchange: EDIF and VHDL. We expect that the results from this research carry over to other design formats.

The concept of decisional power is introduced and compared with other measures for power like those of Shapley‐Shubik, Banzhaf and Dahl. The sum of the powers of all actors in a social network is maximal for certain structures of the network. These structures are called completely democratic. Completely democratic structures are characterized. In every network dictator sets are present. These can be found by use of Boole polynomials. Decisional power turns out to‐have both a causal aspect and a utility aspect and to allow for variations that express the power over other persons as well as the power in a certain state of the network.