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Summary: As a frequently consumed beverage worldwide, tea is rich in naturally important bioactive metabolites. Combining genetic, metabolomic and biochemical methodologies, here, we present a comprehensive study to dissect the chemical diversity in tea plant. A total of 2837 metabolites were identified at high‐resolution with 1098 of them being structurally annotated and 63 of them were structurally identified. Metabolite‐based genome‐wide association mapping identified 6199 and 7823 metabolic quantitative trait loci (mQTL) for 971 and 1254 compounds in young leaves (YL) and the third leaves (TL), respectively. The major mQTL (i.e., P < 1.05 × 10−5, and phenotypic variation explained (PVE) > 25%) were further interrogated. Through extensive annotation of the tea metabolome as well as network‐based analysis, this study broadens the understanding of tea metabolism and lays a solid foundation for revealing the natural variations in the chemical composition of the tea plant. Interestingly, we found that galloylations, rather than hydroxylations or glycosylations, were the largest class of conversions within the tea metabolome. The prevalence of galloylations in tea is unusual, as hydroxylations and glycosylations are typically the most prominent conversions of plant specialized metabolism. The biosynthetic pathway of flavonoids, which are one of the most featured metabolites in tea plant, was further refined with the identified metabolites. And we demonstrated the further mining and interpretation of our GWAS results by verifying two identified mQTL (including functional candidate genes CsUGTa, CsUGTb, and CsCCoAOMT) and completing the flavonoid biosynthetic pathway of the tea plant. [ABSTRACT FROM AUTHOR]

Objective To investigate the state of middle school students' obesity in Xiangtan, China and to study the influence of Internet addiction on obesity. Subjects: 1,150 junior and senior middle school students in Xiangtan, China. Design and Methods The research subjects were select randomly for the study. The height and body weight of human body were measured and the obesity state was judged according to BMI value and the Working Group on Obesity in China (WGOC) standard. The questionnaire for the survey of middle school students' basic situation was designed and a survey of the respondents' personal information and the contributory factors to obesity was conducted. The Middle School Students' Internet Addiction Diagnosis Scale was adopted for measuring and judging the Internet addiction of the research subjects. Results (1) The total detection rate of obesity was 23.57%. (2) The overall detection rate of Internet addiction was 21.23%. (3) The detection rate of obesity in middle school students with Internet addiction (32.92%) was significantly higher than that without Internet addiction (21.06%). Logistic regression showed that Internet addiction was an independent risk factor of obesity. Conclusion Internet addiction is related to obesity of middle school students. [ABSTRACT FROM AUTHOR]

Background: Adolescence is a period characterized by high frequency of mental health problems. Loneliness, in particular, is a common psychological problem. This study aims to explore the effects of psychological capital on adolescents' loneliness and the mediating effects of perceived social support., Subjects and Methods: A total of 694 adolescents from six regions in Hunan Province, China were selected. The survey was conducted using the Perceived Social Support Scale, Loneliness Scale, and Psychological Capital Questionnaire. The study analyzed the correlations between perceived social support, psychological capital, and loneliness among adolescents and the mediating role of psychological capital in the relationship between perceived social support and loneliness., Results: Significant correlations were observed between adolescents' total scores in perceived social support, psychological capital, and loneliness and between each dimension. The following observations were made: a significant negative correlation between perceived social support and loneliness (r=0.440, P<0.01), a significant positive correlation between perceived social support and psychological capital (r=0.493, P<0.01), and a significant negative correlation between psychological capital and loneliness (r=-0.303, P<0.01). Psychological capital plays a statistically significant mediating role on the relationship between perceived social support and loneliness (P<0.01)., Conclusions: Perceived social support and psychological capital can reduce adolescents' loneliness and perceived social support can alleviate loneliness by enhancing psychological capital.

Background: At present, the mental health of rural left-behind children is a major social problem in China. Internet addiction, social anxiety, and loneliness are common psychological and behavioral problems among rural left-behind children, but the relationships among these issues have not been clearly identified., Methods: A total of 432 junior year 1 to senior year 3 students were randomly selected from 2 rural middle schools in Hunan Province of China as the research subjects. The Internet Addiction Disorder Diagnostic Scale, Social Anxiety Subscale of the Self-Consciousness Scale (SASS-CS), and University of California Los Angeles Loneliness Scale were employed to measure the degree of Internet addiction, feelings of social fear, social avoidance behavior, and the level of loneliness among the research subjects., Results: The rate of Internet addiction among rural left-behind middle school students was 18.27%, and was correlated with the length of time their parents spent at home as well as whether one or both parents migrated for work. Positive correlations were found among Internet addiction, social anxiety, and loneliness. Loneliness was found to play a mediating role in the relationship between social anxiety and Internet addiction among rural left-behind middle school students., Conclusion: Social anxiety and loneliness both increase the likelihood of Internet addiction in rural left-behind middle school students and social anxiety can affect Internet addiction through loneliness, implying an urgent need to strengthen care for rural left-behind children, reduce their loneliness, and thereby effectively alleviate the problem of Internet addiction among rural left-behind middle school students., Competing Interests: Conflict of Interest The authors declare that there is no conflict of interests.

Background: Depression is a common mental disorder that is widely seen among adolescents suffering from mobile phone addiction. While it is well known that both positive emtions in adolescents wiotions and social support can have a positive impact by helping individuals to maintain a positive attitude, the correlation between positive emotions, social support, and depression among these adolescents remains to be investigated. This study examined the mediator effects of positive emotions on the relationship between social support and depression among adolescents suffering from mobile phone addiction., Subjects and Methods: For this study, conducted in 2016, we selected 1,346 adolescent students from three middle schools (ranging from Junior Grade One to Senior Grade Three) in Hunan Province of China, to participate in the survey. Participants were selected using the stratified cluster random sampling method, and all participants remained anonymous throughout the study. Each participant completed the Self-made General Situation Questionnaire, the Social Support Rating Scale, the Positive and Negative Affect Schedule, the Center for Epidemiological Studies Depression Scale, and the Mobile Phone Addiction Tendency Scale., Results: There was significant positive correlation between positive emotions and social support. Both positive emotions and social support demonstrated significant negative correlation with depression. Positive emotions had partial mediator effects on the relationship between social support and depression (P<0.01)., Conclusions: Both social support and positive emotions can lower levels of depression among adolescents suffering from mobile phone addiction. Social support contributes to positive emoth mobile phone addiction, thereby reducing their levels of depression. These findings suggest that more support and care should be given to this particular adolescent population.

Background: The aim of this study was to investigate the effects of exercise dependence on the psychological health of Chinese college students., Subjects and Methods: A total of 1601 college students from three universities in Hunan, China, were selected as research subjects. Several measurement scales, including the Exercise Addiction Inventory, the State-Trait Anxiety Inventory, the Center for Epidemiologic Studies Depression Scale, and the Subjective Well-being Scale, were used to survey the psychological health problem of these students and to analyze the effects of exercise dependence on their psychological health., Results: Exercise dependence, based on the structural equation model analysis, can positively influence state anxiety (P<0.05), depression (P<0.05), and subjective well-being (P<0.05) of Chinese students. By contrast, exercise dependence negatively influences students' self-satisfaction (P<0.05), social behavior (P<0.05), and vigor (P<0.05)., Conclusions: Exercise dependence adversely affects the psychological health of college students. Further research using multi-dimensional exercise addiction scales should be conducted to identify all the negative effects of exercise addiction factors on psychological health.

Objective: To investigate the criterion-related validity of Menopause-Specific Quality of Life Questionnaire (MENQOL)-Chinese version and to evaluate the effect of menopausal symptoms on health related quality of life., Methods: This study was a cross-sectional survey. Three communities were randomly chosen in Changsha, and then 340 menopausal women aged 45-55 years were randomly chosen from the documented data of the 3 community health service centers. They were required to fill out 4 questionnaires: demographic questionnaire, MENQOL-Chinese version, Kupperman Index (KI) and World Health Organization Quality of Life (WHQOL)-BREF. Correlation analysis was used to measure the criterion-related validity., Results: MENQOL-Chinese version subscales (vasomotor, psycho-social, sexual and physical) and KI total score were positively correlated (r=0.800, 0.751, 0.607, 0.906 respectively); while negatively correlated with WHOQOL-BREF total score (r =-0.694, -0.851, -0.585, -0.873 respectively); MENQOL-Chinese version subscales (vasomotor, psycho-social, sexual and physical) were significantly correlated with WHOQOL-BREF subscales (physical, psychological, social relationship, environment), and the physical domain was the highest among the correlation coefficients (r=-0.915)., Conclusion: MENQOL-Chinese version shows relatively high criterion-related validity compared with KI and WHOQOL-BREF, which can be widely used to measure the quality of life of menopause women in China.