Search

Your search keyword '"Ren, Xueling"' showing total 36 results
Start Over Author "Ren, Xueling"
36 results on '"Ren, Xueling"'

10. Molecular epidemiology and clinical features of hand, foot and mouth disease requiring hospitalization after the use of enterovirus A71 inactivated vaccine in chengdu, China, 2017-2022: a descriptive study

Author

Duan, Xiaoxia, primary, Zhang, Chaoyong, additional, Wang, Xiao, additional, Ren, Xueling, additional, Peng, Hongxia, additional, Tang, Xueqin, additional, Zhang, Liangzhi, additional, Chen, Zhenhua, additional, Ye, Yan, additional, Zheng, Mengmou, additional, Zhong, Wanzhen, additional, Chen, Xiyue, additional, Zeng, Yilan, additional, Yuan, Ping, additional, and Long, Lu, additional

Published
2022
Full Text
View/download PDF

11. Additional file 1 of Relationship between meteorological factors, air pollutants and hand, foot and mouth disease from 2014 to 2020

Author

Peng, Hongxia, Chen, Zhenhua, Cai, Lin, Liao, Juan, Zheng, Ke, Li, Shuo, Ren, Xueling, Duan, Xiaoxia, Tang, Xueqin, Wang, Xiao, Long, Lu, and Yang, Chunxia

Abstract

Additional file 1: Table S1. Description of environmental factors in Chengdufrom 2014 to 2016. Table S2. Description ofenvironmental factors in Chengdu from 2017 to 2020. Table S3. Descriptionof environmental factors in Chengdu in 2020. Table S4. The overallestimated RR of different meteorological and air pollution factors in differentyears. Table S5. The overall estimated RR of different meteorologicaland air pollutants factors in different age. Fig S1. 3-D plot of RRalong meteorological variables and lags in pre-vaccination period. Fig S2.3-D plot of RR along air pollutants and lags in pre-vaccination period. Fig S3.3-D plot of RR along meteorological variables and lags in post-vaccinationperiod. Fig S4. 3-D plot of RR along air pollutants and lags inpost-vaccination period. Fig S5. 3-D plot of RR along meteorological variablesand lags in COVID-19 period. Fig S6. 3-D plot of RR along air pollutantsand lags in COVID-19 period. Fig S7. Extreme environmental variableswith HFMD incidence in in pre-vaccination period. Fig S8. Extremeenvironmental variables with HFMD incidence in post-vaccination period. Fig S9.Extreme environmental variables with HFMD incidence in COVID-19 period. Fig S10.Extreme meteorological and pollutants variables with HFMD incidence from 2014-2020.Fig S11. Low levels of meteorological and pollutants variables with HFMDincidence in different age. Fig S12. High levels of meteorological andpollutants variables with HFMD incidence in different age. Fig S13.Extreme meteorological and pollutants variables with HFMD incidence indifferent gender.

Published
2022
Full Text
View/download PDF

13. Chronic Lung Disease and the Risk of Cardiovascular Disease: Based on Two Chinese National Prospective Cohort Studies

Author

Ren, Xueling, primary, Wang, Shengshu, additional, Lian, Junsong, additional, Pan, Chunjiang, additional, Li, Baobao, additional, He, Yan, additional, Zhao, Jing, additional, Wang, Dan, additional, Luo, Zheng, additional, Shen, Jiangqiong, additional, Sun, Zhifeng, additional, Hou, Yanka, additional, Qi, Lin, additional, Lu, Qian, additional, Lv, Ping, additional, Wang, Yuling, additional, and Yong, Qinge, additional

Published
2022
Full Text
View/download PDF

18. The Research on Materials and Technique of 'The lion rolling ball' parcel cloth of Qing Dynasty

Author

Ren Xueling and Wang Shaobo

Subjects
Engineering (General). Civil engineering (General), TA1-2040
Abstract

By studying on the little cotton textures from relics excavation, there is not a clear answer to when the China cotton planting started. Although Qiru area was the north weaving center, there were not so much unearthed fabrics. “The lion rolling ball” parcel cloth of Qing Dynasty is one of the seldom printed cottons. It contains rich culture, life custom and the information of weaving technology with cotton in the Qilu region. From the view of history, this paper analyzes the pattern model, fiber material, weaving technology of “The lion rolling ball” parcel cloth of Qing Dynasty. By comparing it with modern Lu brocade using empirical analysis method, we found that the yarns in fabric is cotton, one of ancient Asia cottons, which showed “The lion rolling ball” parcel cloth of Qing Dynasty played an important role in the history of cotton clothes.

Published
2016
Full Text
View/download PDF

20. Nanoparticle siRNA against BMI-1 with a Polyethylenimine–Laminarin Conjugate for Gene Therapy in Human Breast Cancer

Author

Huixiang Li, Yan Zhu, Zhenzhong Zhang, Ren Xueling, Hong Zhang, Lei Liu, and Yuxue Zhou

Subjects
0301 basic medicine, Small interfering RNA, Genetic enhancement, Biomedical Engineering, Pharmaceutical Science, Breast Neoplasms, Bioengineering, 02 engineering and technology, Bioinformatics, Metastasis, 03 medical and health sciences, chemistry.chemical_compound, Laminarin, In vivo, medicine, Animals, Humans, Polyethyleneimine, Tissue Distribution, Molecular Targeted Therapy, RNA, Small Interfering, Glucans, Mitogen-Activated Protein Kinase 7, Pharmacology, Mice, Inbred BALB C, Polyethylenimine, Organic Chemistry, Gene Transfer Techniques, Cancer, Genetic Therapy, 021001 nanoscience & nanotechnology, medicine.disease, Xenograft Model Antitumor Assays, In vitro, 030104 developmental biology, chemistry, MCF-7 Cells, Cancer research, Nanoparticles, Female, 0210 nano-technology, Biotechnology
Abstract

The B-cell-specific Moloney leukemia virus inset site 1 gene (BMI-1) has attracted considerable attention in recent years because of its key role in breast cancer development and metastasis. The downregulation of BMI-1 expression via small interfering RNA (siRNA) effectively inhibits tumor growth. However, the successful application of this therapy is limited by the unavailability of an appropriate vector for siRNA transfer. Therefore, this study aimed to construct a novel laminarin-based nonviral gene transfer vector to carry a constructed BMI-1-targeting siRNA and to investigate the in vitro and in vivo antitumor effects of this siRNA on breast cancer cells. To enhance the siRNA-carrying capacity, we introduced polyethylenimine (PEI) to laminarin's surface via N,N'-carbonyldiimidazole, which produced the cationic PEI-modified laminarin conjugate nLP. Subsequent in vitro experiments indicated that nLP not only formed a nanoparticle with a diameter of 200 nm through electrostatic interactions with siRNA but also showed high efficiency (95.0%) in the delivery siRNA to MCF-7 cells. The nanoparticle targeting BMI-1 (nLP/siBMI-2) reduced BMI-1 expression in breast MCF-7 cells by 90.9% reduction. An in vivo tumor suppression experiment demonstrated that the nLP/siBMI-2 nanoparticle had relatively low toxicity and good gene-therapeutic efficacy, with a tumor inhibition rate of 46.6%.

Published
2015

25. Photoactivatable RNAi for cancer gene therapy triggered by near-infrared-irradiated single-walled carbon nanotubes

Author

Ren,Xueling, Lin,Jing, Wang,Xuefang, Liu,Xiao, Meng,Erjuan, Zhang,Rui, Sang,Yanxiao, Zhang,Zhenzhong, Ren,Xueling, Lin,Jing, Wang,Xuefang, Liu,Xiao, Meng,Erjuan, Zhang,Rui, Sang,Yanxiao, and Zhang,Zhenzhong

Abstract

Xueling Ren, Jing Lin, Xuefang Wang, Xiao Liu, Erjuan Meng, Rui Zhang, Yanxiao Sang, Zhenzhong Zhang Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, People’s Republic of China Abstract: The efficacy of RNA interference (RNAi)-based cancer gene therapy is limited by its unexpected side effects, thus necessitating a strategy to precisely trigger conditional gene knockdown. In this study, we engineered a novel photoactivatable RNAi system, named as polyetherimide-modified single-wall carbon nanotube (PEI-SWNT)/pHSP-shT, that enables optogenetic control of targeted gene suppression in tumor cells. PEI-SWNT/pHSP-shT comprises a stimulus-responsive nanocarrier (PEI-SWNT), and an Hsp70B'-promoter-driven RNAi vector (pHSP-shT). In response to near-infrared (NIR) light irradiation, heating of PEI-SWNT in breast MCF-7 cells triggered gene knockdown targeting human telomerase reverse transcriptase through RNAi, with the gene-knockdown activity capable of being switched off by extinguishing the NIR. Furthermore, we demonstrated that the photoactivatable RNAi system exhibited higher antitumor activity by combining gene therapy and photothermal therapy, both in vitro and in vivo. Optogenetic control of RNAi based on an NIR-activated nanocarrier will potentially facilitate improved understanding of molecular-targeted gene therapy in human malignant tumors. Keywords: near-infrared light response, SWNT, RNAi, Hsp70B' promoter

Published
2017

27. Impacts of Alternaria alternata stress on characteristics of photosynthesis and chlorophyll fluorescence in two tobacco Cultivars with Different Resistances

Author

张小全 Zhang Xiaoquan, 任周营 Ren Zhouying, 杨志晓 Yang Zhixiao, 丁燕芳 Ding Yangfang, 王轶 Wang Yi, 薛刚 Xue Gang, 杨铁钊 Yang Tiezhao, and 任学良 Ren Xueling

Subjects
Ecology, biology, Chemistry, Botany, Cultivar, Photosynthesis, biology.organism_classification, Chlorophyll fluorescence, Alternaria alternata, Ecology, Evolution, Behavior and Systematics
Published
2015

33. A luminescent Zr-based metal–organic framework for sensing/capture of nitrobenzene and high-pressure separation of CH4/C2H6.

Author

Zou, Ruyi, Ren, Xueling, Huang, Fang, Zhao, Yifang, Liu, Jia, Jing, Xiping, Liao, Fuhui, Wang, Yinxia, Lin, Jianhua, Zou, Ruqiang, and Sun, Junliang

Abstract

We present a novel luminescent metal–organic framework (LMOF) based on zirconium metal oxide cluster Zr6O8 bonding with a new tetratopic linker 1,3,6,8-tetrakis(4′-carboxy[1,1′-biphenyl]-4-yl-)pyrene. This (4,12)-connected ftw-a-type net is composed of a large solvent-accessible volume of 79.5% volume per unit cell with a BET surface area up to 3540.5 m2 g−1. The activated LMOF exhibits an unprecedented fluorescence quenching effect triggered by nitrobenzene (NB) with quench percentage up to 99.5%, and could reversibly take up 14.7 mmol g−1 of NB under atmospheric conditions. The breakthrough curve of CH4 and C2H6 at 298 K and 2.0 MPa demonstrates that the activated LMOF has high-performance selective adsorption for CH4 with a selectivity of 25.45, which is an unusually high value as compared with those of reported materials. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

36. Nanoparticle siRNA against BMI-1 with a Polyethylenimine-Laminarin Conjugate for Gene Therapy in Human Breast Cancer.

Author

Ren X, Liu L, Zhou Y, Zhu Y, Zhang H, Zhang Z, and Li H

Subjects
Animals, Breast Neoplasms genetics, Female, Gene Transfer Techniques, Glucans chemistry, Humans, MCF-7 Cells, Mice, Inbred BALB C, Molecular Targeted Therapy, Nanoparticles administration & dosage, Nanoparticles toxicity, Polyethyleneimine chemistry, RNA, Small Interfering chemistry, RNA, Small Interfering pharmacokinetics, Tissue Distribution, Xenograft Model Antitumor Assays, Breast Neoplasms therapy, Genetic Therapy methods, Mitogen-Activated Protein Kinase 7 genetics, Nanoparticles chemistry, RNA, Small Interfering administration & dosage
Abstract

The B-cell-specific Moloney leukemia virus inset site 1 gene (BMI-1) has attracted considerable attention in recent years because of its key role in breast cancer development and metastasis. The downregulation of BMI-1 expression via small interfering RNA (siRNA) effectively inhibits tumor growth. However, the successful application of this therapy is limited by the unavailability of an appropriate vector for siRNA transfer. Therefore, this study aimed to construct a novel laminarin-based nonviral gene transfer vector to carry a constructed BMI-1-targeting siRNA and to investigate the in vitro and in vivo antitumor effects of this siRNA on breast cancer cells. To enhance the siRNA-carrying capacity, we introduced polyethylenimine (PEI) to laminarin's surface via N,N'-carbonyldiimidazole, which produced the cationic PEI-modified laminarin conjugate nLP. Subsequent in vitro experiments indicated that nLP not only formed a nanoparticle with a diameter of 200 nm through electrostatic interactions with siRNA but also showed high efficiency (95.0%) in the delivery siRNA to MCF-7 cells. The nanoparticle targeting BMI-1 (nLP/siBMI-2) reduced BMI-1 expression in breast MCF-7 cells by 90.9% reduction. An in vivo tumor suppression experiment demonstrated that the nLP/siBMI-2 nanoparticle had relatively low toxicity and good gene-therapeutic efficacy, with a tumor inhibition rate of 46.6%.

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results