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1. Light Dark Matter Constraints from SuperCDMS HVeV Detectors Operated Underground with an Anticoincidence Event Selection

Author: SuperCDMS Collaboration, Albakry, M. F., Alkhatib, I., Alonso-González, D., Amaral, D. W. P., Anczarski, J., Aralis, T., Aramaki, T., Arnquist, I. J., Langroudy, I. Ataee, Azadbakht, E., Bathurst, C., Bhattacharyya, R., Biffl, A. J., Brink, P. L., Buchanan, M., Bunker, R., Cabrera, B., Calkins, R., Cameron, R. A., Cartaro, C., Cerdeño, D. G., Chang, Y. -Y., Chaudhuri, M., Chen, J. -H., Chen, R., Chott, N., Cooley, J., Coombes, H., Cushman, P., Cyna, R., Das, S., De Brienne, F., Dharani, S., di Vacri, M. L., Diamond, M. D., Elwan, M., Fascione, E., Figueroa-Feliciano, E., Fouts, K., Fritts, M., Germond, R., Ghaith, M., Golwala, S. R., Hall, J., Harms, S. A. S., Harris, K., Hassan, N., Hong, Z., Hoppe, E. W., Hsu, L., Huber, M. E., Iyer, V., Jardin, D., Kashyap, V. K. S., Keller, S. T. D., Kelsey, M. H., Kennard, K. T., Kubik, A., Kurinsky, N. A., Lee, M., Leyva, J., Liu, J., Liu, Y., Loer, B., Asamar, E. Lopez, Lukens, P., MacFarlane, D. B., Mahapatra, R., Mammo, J. S., Mast, N., Mayer, A. J., Theenhausen, H. Meyer zu, Michaud, É., Michielin, E., Mirabolfathi, N., Mirzakhani, M., Mohanty, B., Monteiro, D., Nelson, J., Neog, H., Novati, V., Orrell, J. L., Osborne, M. D., Oser, S. M., Pandey, L., Pandey, S., Partridge, R., Pedreros, D. S., Peng, W., Perna, L., Perry, W. L., Podviianiuk, R., Poudel, S. S., Pradeep, A., Pyle, M., Rau, W., Reid, E., Ren, R., Reynolds, T., Rios, M., Roberts, A., Robinson, A. E., Ryan, J. L., Saab, T., Sadek, D., Sadoulet, B., Sahoo, S. P., Saikia, I., Sander, J., Sattari, A., Schmidt, B., Schnee, R. W., Scorza, S., Serfass, B., Simchony, A., Sincavage, D. J., Sinervo, P., Street, J., Sun, H., Tanner, E., Terry, G. D., Toback, D., Verma, S., Villano, A. N., von Krosigk, B., Watkins, S. L., Wen, O., Williams, Z., Wilson, M. J., Winchell, J., Wykoff, K., Yellin, S., Young, B. A., Yu, T. C., Zatschler, B., Zatschler, S., Zaytsev, A., Zhang, E., Zheng, L., Zuniga, A., and Zurowski, M. J.
Subjects: High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics, Physics - Instrumentation and Detectors
Abstract: This article presents constraints on dark-matter-electron interactions obtained from the first underground data-taking campaign with multiple SuperCDMS HVeV detectors operated in the same housing. An exposure of 7.63 g-days is used to set upper limits on the dark-matter-electron scattering cross section for dark matter masses between 0.5 and 1000 MeV/$c^2$, as well as upper limits on dark photon kinetic mixing and axion-like particle axioelectric coupling for masses between 1.2 and 23.3 eV/$c^2$. Compared to an earlier HVeV search, sensitivity was improved as a result of an increased overburden of 225 meters of water equivalent, an anticoincidence event selection, and better pile-up rejection. In the case of dark-matter-electron scattering via a heavy mediator, an improvement by up to a factor of 25 in cross-section sensitivity was achieved., Comment: 7 pages + title and references, 4 figures, and 1 table
Published: 2024

2. First demonstration of a TES based cryogenic Li$_2$MoO$_4$detector for neutrinoless double beta decay search

Author: Bratrud, G., Chang, C. L., Chen, R., Cudmore, E., Figueroa-Feliciano, E., Hong, Z., Kennard, K. T., Lewis, S., Lisovenko, M., Mateo, L. O., Novati, V., Novosad, V., Oliveri, E., Ren, R., Scarpaci, J. A., Schmidt, B., Wang, G., Winslow, L., Yefremenko, V. G., Zhang, J., Baxter, D., Hollister, M., James, C., Lukens, P., and Temples, D. J.
Subjects: High Energy Physics - Experiment, Nuclear Experiment, Physics - Instrumentation and Detectors
Abstract: Cryogenic calorimetric experiments to search for neutrinoless double-beta decay ($0\nu\beta\beta$) are highly competitive, scalable and versatile in isotope. The largest planned detector array, CUPID, is comprised of about 1500 individual Li$_2^{100}$MoO$_{4}$ detector modules with a further scale up envisioned for a follow up experiment (CUPID-1T). In this article, we present a novel detector concept targeting this second stage with a low impedance TES based readout for the Li$_2$MoO$_{4}$ absorber that is easily mass-produced and lends itself to a multiplexed readout. We present the detector design and results from a first prototype detector operated at the NEXUS shallow underground facility at Fermilab. The detector is a 2-cm-side cube with 21$\,$g mass that is strongly thermally coupled to its readout chip to allow rise-times of $\sim$0.5$\,$ms. This design is more than one order of magnitude faster than present NTD based detectors and is hence expected to effectively mitigate backgrounds generated through the pile-up of two independent two neutrino decay events coinciding close in time. Together with a baseline resolution of 1.95$\,$keV (FWHM) these performance parameters extrapolate to a background index from pile-up as low as $5\cdot 10^{-6}\,$counts/keV/kg/yr in CUPID size crystals. The detector was calibrated up to the MeV region showing sufficient dynamic range for $0\nu\beta\beta$ searches. In combination with a SuperCDMS HVeV detector this setup also allowed us to perform a precision measurement of the scintillation time constants of Li$_2$MoO$_{4}$. The crystal showed a significant fast scintillation emission with O(10$\,\mu$s) time-scale, more than an order below the detector response of presently considered light detectors suggesting the possibility of further progress in pile-up rejection through better light detectors in the future.
Published: 2024

3. First Measurement of Correlated Charge Noise in Superconducting Qubits at an Underground Facility

Author: Bratrud, G., Lewis, S., Anyang, K., Cesaní, A. Colón, Dyson, T., Magoon, H., Sabhari, D., Spahn, G., Wagner, G., Gualtieri, R., Kurinsky, N. A., Linehan, R., McDermott, R., Sussman, S., Temples, D. J., Uemura, S., Bathurst, C., Cancelo, G., Chen, R., Chou, A., Hernandez, I., Hollister, M., Hsu, L., James, C., Kennard, K., Khatiwada, R., Lukens, P., Novati, V., Raha, N., Ray, S., Ren, R., Rodriguez, A., Schmidt, B., Stifter, K., Yu, J., Baxter, D., Figueroa-Feliciano, E., and Bowring, D.
Subjects: Quantum Physics, High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract: We measure space- and time-correlated charge jumps on a four-qubit device, operating 107 meters below the Earth's surface in a low-radiation, cryogenic facility designed for the characterization of low-threshold particle detectors. The rock overburden of this facility reduces the cosmic ray muon flux by over 99% compared to laboratories at sea level. Combined with 4$\pi$ coverage of a movable lead shield, this facility enables quantifiable control over the flux of ionizing radiation on the qubit device. Long-time-series charge tomography measurements on these weakly charge-sensitive qubits capture discontinuous jumps in the induced charge on the qubit islands, corresponding to the interaction of ionizing radiation with the qubit substrate. The rate of these charge jumps scales with the flux of ionizing radiation on the qubit package, as characterized by a series of independent measurements on another energy-resolving detector operating simultaneously in the same cryostat with the qubits. Using lead shielding, we achieve a minimum charge jump rate of 0.19$^{+0.04}_{-0.03}$ mHz, almost an order of magnitude lower than that measured in surface tests, but a factor of roughly eight higher than expected based on reduction of ambient gammas alone. We operate four qubits for over 22 consecutive hours with zero correlated charge jumps at length scales above three millimeters., Comment: 12 pages, 6 figures, 4 tables. Minor update to the measured gamma flux ratio (Page 4 and Supplemental Section F) in the LMO detector, from 23 to 20. Typos corrected, references added. Extraneous .tex files have been removed that were causing errors with the "HTML (experimental)" arxiv feature
Published: 2024

4. Improved Modelling of Detector Response Effects in Phonon-based Crystal Detectors used for Dark Matter Searches

Author: Wilson, M. J., Zaytsev, A., von Krosigk, B., Alkhatib, I., Buchanan, M., Chen, R., Diamond, M. D., Figueroa-Feliciano, E., Harms, S. A. S., Hong, Z., Kennard, K. T., Kurinsky, N. A., Mahapatra, R., Mirabolfathi, N., Novati, V., Platt, M., Ren, R., Sattari, A., Schmidt, B., Wang, Y., Zatschler, S., Zhang, E., and Zuniga, A.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: Various dark matter search experiments employ phonon-based crystal detectors operated at cryogenic temperatures. Some of these detectors, including certain silicon detectors used by the SuperCDMS Collaboration, are able to achieve single-charge sensitivity when a voltage bias is applied across the detector. The total amount of phonon energy measured by such a detector is proportional to the number of electron-hole pairs created by the interaction. However, crystal impurities and surface effects can cause propagating charges to either become trapped inside the crystal or create additional unpaired charges, producing non-quantized measured energy as a result. A new analytical model for describing these detector response effects in phonon-based crystal detectors is presented. This model improves upon previous versions by demonstrating how the detector response, and thus the measured energy spectrum, is expected to differ depending on the source of events. We use this model to extract detector response parameters for SuperCDMS HVeV detectors, and illustrate how this robust modelling can help statistically discriminate between sources of events in order to improve the sensitivity of dark matter search experiments., Comment: 19 pages, 7 figures
Published: 2024
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5. First measurement of the nuclear-recoil ionization yield in silicon at 100 eV

Author: Albakry, M. F., Alkhatib, I., Alonso, D., Amaral, D. W. P., An, P., Aralis, T., Aramaki, T., Arnquist, I. J., Langroudy, I. Ataee, Azadbakht, E., Banik, S., Barbeau, P. S., Bathurst, C., Bhattacharyya, R., Brink, P. L., Bunker, R., Cabrera, B., Calkins, R., Cameron, R. A., Cartaro, C., Cerdeño, D. G., Chang, Y. -Y., Chaudhuri, M., Chen, R., Chott, N., Cooley, J., Coombes, H., Corbett, J., Cushman, P., Das, S., De Brienne, F., Rios, M., Dharani, S., di Vacri, M. L., Diamond, M. D., Elwan, M., Fascione, E., Figueroa-Feliciano, E., Fink, C. W., Fouts, K., Fritts, M., Gerbier, G., Germond, R., Ghaith, M., Golwala, S. R., Hall, J., Hassan, N., Hedges, S. C., Hines, B. A., Hong, Z., Hoppe, E. W., Hsu, L., Huber, M. E., Iyer, V., Kashyap, V. K. S., Kelsey, M. H., Kubik, A., Kurinsky, N. A., Lee, M., Li, A., Li, L., Litke, M., Liu, J., Liu, Y., Loer, B., Asamar, E. Lopez, Lukens, P., MacFarlane, D. B., Mahapatra, R., Mandic, V., Mast, N., Mayer, A. J., Theenhausen, H. Meyer zu, Michaud, ., Michielin, E., Mirabolfathi, N., Mohanty, B., Nebolsky, B., Nelson, J., Neog, H., Novati, V., Orrell, J. L., Osborne, M. D., Oser, S. M., Page, W. A., Pandey, S., Partridge, R., Pedreros, D. S., Perna, L., Podviianiuk, R., Ponce, F., Poudel, S., Pradeep, A., Pyle, M., Rau, W., Reid, E., Ren, R., Reynolds, T., Roberts, A., Robinson, A. E., Runge, J., Saab, T., Sadek, D., Sadoulet, B., Saikia, I., Sander, J., Sattari, A., Schmidt, B., Schnee, R. W., Scorza, S., Serfass, B., Poudel, S. S., Sincavage, D. J., Sinervo, P., Speaks, Z., Street, J., Sun, H., Thasrawala, F. K., Toback, D., Underwood, R., Verma, S., Villano, A. N., von Krosigk, B., Watkins, S. L., Wen, O., Williams, Z., Wilson, M. J., Winchell, J., Wykoff, K., Yellin, S., Young, B. A., Yu, T. C., Zatschler, B., Zatschler, S., Zaytsev, A., Zeolla, A., Zhang, E., Zheng, L., Zheng, Y., and Zuniga, A.
Subjects: Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment, Nuclear Experiment
Abstract: We measured the nuclear--recoil ionization yield in silicon with a cryogenic phonon-sensitive gram-scale detector. Neutrons from a mono-energetic beam scatter off of the silicon nuclei at angles corresponding to energy depositions from 4\,keV down to 100\,eV, the lowest energy probed so far. The results show no sign of an ionization production threshold above 100\,eV. These results call for further investigation of the ionization yield theory and a comprehensive determination of the detector response function at energies below the keV scale.
Published: 2023
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6. A Search for Low-mass Dark Matter via Bremsstrahlung Radiation and the Migdal Effect in SuperCDMS

Author: Albakry, M. F., Alkhatib, I., Alonso, D., Amaral, D. W. P., Aralis, T., Aramaki, T., Arnquist, I. J., Langroudy, I. Ataee, Azadbakht, E., Banik, S., Bathurst, C., Bhattacharyya, R., Brink, P. L., Bunker, R., Cabrera, B., Calkins, R., Cameron, R. A., Cartaro, C., Cerdeño, D. G., Chang, Y. -Y., Chaudhuri, M., Chen, R., Chott, N., Cooley, J., Coombes, H., Corbett, J., Cushman, P., Das, S., De Brienne, F., Rios, M., Dharani, S., di Vacri, M. L., Diamond, M. D., Elwan, M., Fascione, E., Figueroa-Feliciano, E., Fink, C. W., Fouts, K., Fritts, M., Gerbier, G., Germond, R., Ghaith, M., Golwala, S. R., Hall, J., Hassan, N., Hines, B. A., Hong, Z., Hoppe, E. W., Hsu, L., Huber, M. E., Iyer, V., Jardin, D., Kashyap, V. K. S., Kelsey, M. H., Kubik, A., Kurinsky, N. A., Lee, M., Li, A., Litke, M., Liu, J., Liu, Y., Loer, B., Asamar, E. Lopez, Lukens, P., MacFarlane, D. B., Mahapatra, R., Mast, N., Mayer, A. J., Theenhausen, H. Meyer zu, Michaud, É., Michielin, E., Mirabolfathi, N., Mohanty, B., Nelson, J., Neog, H., Novati, V., Orrell, J. L., Osborne, M. D., Oser, S. M., Page, W. A., Pandey, S., Partridge, R., Pedreros, D. S., Perna, L., Podviianiuk, R., Ponce, F., Poudel, S., Pradeep, A., Pyle, M., Rau, W., Reid, E., Ren, R., Reynolds, T., Roberts, A., Robinson, A. E., Saab, T., Sadek, D., Sadoulet, B., Saikia, I., Sander, J., Sattari, A., Schmidt, B., Schnee, R. W., Scorza, S., Serfass, B., Poudel, S. S., Sincavage, D. J., Sinervo, P., Street, J., Sun, H., Terry, G. D., Thasrawala, F. K., Toback, D., Underwood, R., Verma, S., Villano, A. N., von Krosigk, B., Watkins, S. L., Wen, O., Williams, Z., Wilson, M. J., Winchell, J., Wu, C. -P., Wykoff, K., Yellin, S., Young, B. A., Yu, T. C., Zatschler, B., Zatschler, S., Zaytsev, A., Zhang, E., Zheng, L., and Zuniga, A.
Subjects: High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract: We present a new analysis of previously published of SuperCDMS data using a profile likelihood framework to search for sub-GeV dark matter (DM) particles through two inelastic scattering channels: bremsstrahlung radiation and the Migdal effect. By considering these possible inelastic scattering channels, experimental sensitivity can be extended to DM masses that are undetectable through the DM-nucleon elastic scattering channel, given the energy threshold of current experiments. We exclude DM masses down to $220~\textrm{MeV}/c^2$ at $2.7 \times 10^{-30}~\textrm{cm}^2$ via the bremsstrahlung channel. The Migdal channel search provides overall considerably more stringent limits and excludes DM masses down to $30~\textrm{MeV}/c^2$ at $5.0 \times 10^{-30}~\textrm{cm}^2$., Comment: Submitted to PRD
Published: 2023
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7. Usefulness of the Systemic Inflammation Response Index and the Systemic Immune Inflammation Index in Predicting Restenosis After Stent Implantation

Author: Xu P, Cao Y, Ren R, Zhang S, Zhang C, Hao P, and Zhang M
Subjects: siri, sii, in-stent restenosis, percutaneous coronary intervention, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Panpan Xu,1– 3 Yu Cao,1– 3 Ruiqing Ren,1– 3 Shuai Zhang,1– 3 Cheng Zhang,1– 3 Panpan Hao,1– 3 Meng Zhang1– 3 1State Key Laboratory for Innovation and Transformation of Luobing Theory, Jinan, People’s Republic of China; 2Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Jinan, People’s Republic of China; 3Department of Cardiology, Qilu Hospital of Shandong University, Jinan, People’s Republic of ChinaCorrespondence: Meng Zhang; Panpan Hao, Department of Cardiology, Qilu Hospital of Shandong University, No. 107, Wenhuaxi Road, Jinan, Shandong, 250012, People’s Republic of China, Email zhangmeng@sdu.edu.cn; panda.how@sdu.edu.cnPurpose: The systemic inflammation response index (SIRI) and the systemic immune inflammation index (SII) are indicators that reflect the body’s overall systemic inflammatory response. Inflammation plays an important role in the pathogenesis of in-stent restenosis (ISR). The aim of this study was to investigate the predictive value of preoperative SIRI and SII for the occurrence of ISR in patients undergoing coronary stent implantation.Materials and Methods: We retrospectively analyzed the clinical, hematological, and angiographic data of 387 patients who underwent coronary angiography for recurrent angina after coronary stent implantation at Qilu Hospital of Shandong University. Receiver operating characteristic curve (ROC) analysis was used to determine the optimal cutoff values for SIRI and SII to predict ISR. Based on the optimal cutoff values for SIRI and SII, patients were categorized into high-SIRI, low-SIRI, high-SII, and low-SII groups. Multivariate logistic regression models were constructed to assess the predictive value of SIRI and SII for ISR > 50% and ISR > 70%.Results: This study included a total of 387 patients who underwent coronary angiography and follow-up at Qilu Hospital of Shandong University. Patients in the high-SIRI group had a higher incidence of ISR than those in the low-SIRI group (ISR > 50%: 44.8% vs 30.7%, p = 0.018; ISR > 70%: 41.5% vs 4.5%, p < 0.001). In addition, ISR occurred more frequently in patients with a higher SII than in patients with a lower SII (ISR > 50%: 52.6% vs 35.7%, p = 0.001; ISR > 70%: 51.9% vs 23%, p < 0.001). In multivariate logistic regression analysis, SIRI and SII were found to be independent predictive factors for ISR, both as continuous and categorical variables. In the ROC analysis, the optimal cutoff value for SIRI was set at 0.54 (sensitivity: 84.5%, specificity: 27%), and the optimal cutoff value for SII was set at 545.29 (sensitivity: 44.1%, specificity: 71.7%).Conclusion: Elevated preoperative SIRI and SII values help predict ISR and may serve as a useful screening tool to perform interventional procedures based on the patient’s risk of ISR after stent implantation.Keywords: SIRI, SII, in-stent restenosis, percutaneous coronary intervention
Published: 2024

8. Efficacy and Safety Factors Related to Plasma Concentration-Optimized Polymyxin B Therapy in Treating Carbapenem-Resistant Gram-Negative Bacterial Infections in China

Author: Li L, Huang X, Liu J, Li C, Lin Z, Ren R, Zhang Y, Ding H, Chen J, and Mao Y
Subjects: polymyxin b, pmb therapeutic drug monitoring, tdm, carbapenem-resistant gram-negative bacteria, cr-gnb, clinical efficacy, acute kidney injury, aki, Infectious and parasitic diseases, RC109-216
Abstract: Lixia Li,1,&ast; Xiaohui Huang,1,&ast; Jingxian Liu,2,&ast; Chao Li,1 Zhiyan Lin,1 Rongrong Ren,3 Yan Zhang,3 Haoshu Ding,3 Jihui Chen,1 Yanfei Mao3 1Department of Pharmacy, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 2Department of Clinical Laboratory, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 3Department of Anesthesiology and SICU, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yanfei Mao; Jihui Chen, Email maoyanfei@xinhuamed.com.cn; chenjihui@xinhuamed.com.cnBackground: Polymyxin B (PMB)-based combination therapies are used to treat severe carbapenem-resistant gram-negative bacterial (CR-GNB) infections. This observational study investigated the relationship between clinical factors, including PMB concentration, and clinical efficacy and safety.Patients and Methods: Polymyxin B regimens were optimized through therapeutic drug monitoring (TDM) and area under the concentration-time curve (AUC). In all, 382 samples were tested from 130 patients. Logistic regression was used to analyze the relationships between variables with clinical efficacy and 30-day mortality factors were analyzed by Cox regression. The sensitivity and specificity of Cmin and AUC for the occurrence of acute kidney injury (AKI) were determined by ROC curve analysis.Results: The clinical effectiveness of PMB was 65.4%. Multivariate logistic regression analysis revealed that lung infection, continuous renal replacement therapy, and C-reactive protein were independent factors significantly associated with efficacy. AKI occurred in 14.6% of the patients during treatment; age > 73 years (OR: 3.63; 95% CI: 1.035– 12.727; P = 0.044), Cmin greater than 2.3 μg/mL (OR: 7.37; 95% CI: 1.571– 34.580; P = 0.011), combined vancomycin (OR: 9.47; 95% CI: 1.732– 51.731; P = 0.009), and combined piperacillin-tazobactam (OR: 21.87; 95% CI: 3.139– 152.324; P = 0.002) were independent risk factors. The identified PMB cut-offs for predicting AKI were Cmin = 2.3 μg/mL and AUC = 82.0 mg h/L.Conclusion: Polymyxin B-based combination regimens are effective in treating CR-GNB infections, particularly bloodstream infections, but have shown unsatisfactory for lung infections. Cmin ≥ 2.3 μg /mL and AUC ≥ 82.0 mg h/L may increase PMB-associated AKI incidence. PMB dose should be adjusted based on TDM to ensure efficacy.Keywords: Polymyxin B, PMB therapeutic drug monitoring, TDM, carbapenem-resistant gram-negative bacteria, CR-GNB, clinical efficacy, acute kidney injury, AKI
Published: 2024

9. Quantifying the Adverse Effects of Long COVID on Individuals’ Health After Infection: A Propensity Score Matching Design Study

Author: Miao Y, Ren R, Shen Z, Li Y, Zhang W, Bai J, Zhu D, Zhang J, Guo D, Tarimo CS, Liu R, Zhao Q, Hu J, Zhou X, and Dong W
Subjects: long covid, lifestyles, self-reported health status, propensity score matching, effect of mediation, Public aspects of medicine, RA1-1270
Abstract: Yudong Miao,1 Ruizhe Ren,1 Zhanlei Shen,1 Yi Li,1 Wanliang Zhang,1 Junwen Bai,1 Dongfang Zhu,1 Jingbao Zhang,1 Dan Guo,1,2 Clifford Silver Tarimo,3 Rongmei Liu,4 Qiuping Zhao,4 Jianping Hu,5 Xue Zhou,6 Wenyong Dong7 1College of Public Health, Zhengzhou University, Zhengzhou, People’s Republic of China; 2Department of Neurology, Henan Provincial People’s Hospital, Zhengzhou, People’s Republic of China; 3Department of Science and Laboratory Technology, Dar es Salaam Institute of Technology, Dar es Salaam, Tanzania; 4Henan Key Laboratory for Health Management of Chronic Diseases, Central China Fuwai Hospital, Zhengzhou, People’s Republic of China; 5Henan Medical Communication and Project Forward Center, Zhengzhou, People’s Republic of China; 6College of Health Management, Mudanjiang Medical University, Mudanjiang, People’s Republic of China; 7Department of Hypertension, Henan Provincial People’s Hospital, Zhengzhou, People’s Republic of ChinaCorrespondence: Rongmei Liu, Assistant research fellow. Fuwai Central China Cardiovascular Hospital, Zhengzhou University Affiliated Central China Fuwai Hospital, &num;1, Fuwai Avenue, Zhengdong New District, Zhengzhou, 450014, People’s Republic of China, Tel +8615038204525, Email liuyongmei0203@163.comObjective: To evaluate the prevalence and influencing factors of long COVID, and measure the difference in health status between long COVID and non-long COVID cases.Methods: A cross-sectional survey was conducted from February 1 to 8, 2023, using a stratified random sampling method in four regions (eastern [Changzhou], central [Zhengzhou], western [Xining] and northeastern [Mudanjiang]) of China. The survey collected COVID-19 patients’ socio-demographic characteristics and lifestyles information. The scores of lifestyles and health status range from 5 to 21 and 0 to 100 points, respectively. The criteria of “persistent health problems after 4 weeks of COVID-19 infection” issued by the US Centers for Disease Control and Prevention was used to assess long COVID. Multiple linear regression was used to analyze the influencing factors of the health. The bootstrap method was used to analyze the lifestyles’ mediating effect. Propensity score matching (PSM) was used to evaluate the net difference in health scores between long COVID and non-long COVID cases.Results: The study included 3165 COVID-19 patients, with 308 (9.73%) long COVID cases. The health score of the long COVID cases (74.79) was lower than that of the non-long COVID cases (81.06). After adjusting for potential confounding variables, we found that never focused on mental decompression was a common risk factor for the health of both groups. Lifestyles was the mediating factor on individuals’ health. After PSM, the non-long COVID cases’ health scores remained higher than that of long COVID cases.Conclusion: The proportion of long COVID cases was low, but they were worse off in health. Given the positive moderating effect of healthy lifestyles on improving the health of long COVID cases, healthy lifestyles including mental decompression should be considered as the core strategy of primary prevention when the epidemic of COVID-19 is still at a low level.Keywords: long COVID, lifestyles, self-reported health status, propensity score matching, effect of mediation
Published: 2024

10. Opportunities and Challenges for Inhalable Nanomedicine Formulations in Respiratory Diseases: A Review

Author: Feng X, Shi Y, Zhang Y, Lei F, Ren R, and Tang X
Subjects: nanoparticles, respiratory system, lungs, nanomaterials, nanotechnology, Medicine (General), R5-920
Abstract: Xujun Feng, Yuan Shi, Ye Zhang, Fei Lei, Rong Ren, Xiangdong Tang Department of Respiratory and Critical Care Medicine, Sleep Medicine Center, Mental Health Center, West China Hospital, Sichuan University, Chengdu, People’s Republic of ChinaCorrespondence: Rong Ren; Xiangdong Tang, Department of Respiratory and Critical Care Medicine, Sleep Medicine Center, Mental Health Center, West China Hospital, Sichuan University, Dian Xin Nan Jie 28&num;, Chengdu, 610041, People’s Republic of China, Tel +86-28-85422733, Email 498880651@qq.com; 2372564613@qq.comAbstract: Lungs experience frequent interactions with the external environment and have an abundant supply of blood; therefore, they are susceptible to invasion by pathogenic microorganisms and tumor cells. However, the limited pharmacokinetics of conventional drugs in the lungs poses a clinical challenge. The emergence of different nano-formulations has been facilitated by advancements in nanotechnology. Inhaled nanomedicines exhibit better targeting and prolonged therapeutic effects. Although nano-formulations have great potential, they still present several unknown risks. Herein, we review the (1) physiological anatomy of the lungs and their biological barriers, (2) pharmacokinetics and toxicology of nanomaterial formulations in the lungs; (3) current nanomaterials that can be applied to the respiratory system and related design strategies, and (4) current applications of inhaled nanomaterials in treating respiratory disorders, vaccine design, and imaging detection based on the characteristics of different nanomaterials. Finally, (5) we analyze and summarize the challenges and prospects of nanomaterials for respiratory disease applications. We believe that nanomaterials, particularly inhaled nano-formulations, have excellent prospects for application in respiratory diseases. However, we emphasize that the simultaneous toxic side effects of biological nanomaterials must be considered during the application of these emerging medicines. This study aims to offer comprehensive guidelines and valuable insights for conducting research on nanomaterials in the domain of the respiratory system. Keywords: nanoparticles, respiratory system, lungs, nanomaterials, nanotechnology
Published: 2024

11. Effective Field Theory Analysis of CDMSlite Run 2 Data

Author: SuperCDMS Collaboration, Albakry, M. F., Alkhatib, I., Amaral, D. W. P., Aralis, T., Aramaki, T., Arnquist, I. J., Langroudy, I. Ataee, Azadbakht, E., Banik, S., Bathurst, C., Bauer, D. A., Bezerra, L. V. S., Bhattacharyya, R., Brink, P. L., Bunker, R., Cabrera, B., Calkins, R., Cameron, R. A., Cartaro, C., Cerdeño, D. G., Chang, Y. -Y., Chaudhuri, M., Chen, R., Chott, N., Cooley, J., Coombes, H., Corbett, J., Cushman, P., De Brienne, F., Dharani, S., di Vacri, M. L., Diamond, M. D., Fascione, E., Figueroa-Feliciano, E., Fink, C. W., Fouts, K., Fritts, M., Gerbier, G., Germond, R., Ghaith, M., Golwala, S. R., Hall, J., Hassan, N., Hines, B. A., Hollister, M. I., Hong, Z., Hoppe, E. W., Hsu, L., Huber, M. E., Iyer, V., Jastram, A., Kashyap, V. K. S., Kelsey, M. H., Kubik, A., Kurinsky, N. A., Lawrence, R. E., Lee, M., Li, A., Liu, J., Liu, Y., Loer, B., Lukens, P., MacFarlane, D. B., Mahapatra, R., Mandic, V., Mast, N., Mayer, A. J., Theenhausen, H. Meyer zu, Michaud, É., Michielin, E., Mirabolfathi, N., Mohanty, B., Nagorny, S., Nelson, J., Neog, H., Novati, V., Orrell, J. L., Osborne, M. D., Oser, S. M., Page, W. A., Partridge, R., Pedreros, D. S., Podviianiuk, R., Ponce, F., Poudel, S., Pradeep, A., Pyle, M., Rau, W., Reid, E., Ren, R., Reynolds, T., Roberts, A., Robinson, A. E., Rogers, H. E., Saab, T., Sadoulet, B., Saikia, I., Sander, J., Sattari, A., Schmidt, B., Schnee, R. W., Scorza, S., Serfass, B., Poudel, S. S., Sincavage, D. J., Stanford, C., Street, J., Sun, H., Thasrawala, F. K., Toback, D., Underwood, R., Verma, S., Villano, A. N., von Krosigk, B., Watkins, S. L., Wen, O., Williams, Z., Wilson, M. J., Winchell, J., Wykoff, K., Yellin, S., Young, B. A., Yu, T. C., Zatschler, B., Zatschler, S., Zaytsev, A., Zhang, E., Zheng, L., and Zuber, S.
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Experiment
Abstract: CDMSlite Run 2 was a search for weakly interacting massive particles (WIMPs) with a cryogenic 600 g Ge detector operated in a high-voltage mode to optimize sensitivity to WIMPs of relatively low mass from 2 - 20 GeV/$c^2$. In this article, we present an effective field theory (EFT) analysis of the CDMSlite Run 2 data using an extended energy range and a comprehensive treatment of the expected background. A binned likelihood Bayesian analysis was performed on the recoil energy data, taking into account the parameters of the EFT interactions and optimizing the data selection with respect to the dominant background components. Energy regions within 5$\sigma$ of known activation peaks were removed from the analysis. The Bayesian evidences resulting from the different operator hypotheses show that the CDMSlite Run 2 data are consistent with the background-only models and do not allow for a signal interpretation assuming any additional EFT interaction. Consequently, upper limits on the WIMP mass and coupling-coefficient amplitudes and phases are presented for each EFT operator. These limits improve previous CDMSlite Run 2 bounds for WIMP masses above 5 GeV/$c^2$., Comment: 16 pages, 8 figures
Published: 2022

12. Investigating the sources of low-energy events in a SuperCDMS-HVeV detector

Author: SuperCDMS Collaboration, Albakry, M. F., Alkhatib, I., Amaral, D. W. P., Aralis, T., Aramaki, T., Arnquist, I. J., Langroudy, I. Ataee, Azadbakht, E., Banik, S., Bathurst, C., Bauer, D. A., Bhattacharyya, R., Brink, P. L., Bunker, R., Cabrera, B., Calkins, R., Cameron, R. A., Cartaro, C., Cerdeño, D. G., Chang, Y. -Y., Chaudhuri, M., Chen, R., Chott, N., Cooley, J., Coombes, H., Corbett, J., Cushman, P., De Brienne, F., Dharani, S., di Vacri, M. L., Diamond, M. D., Fascione, E., Figueroa-Feliciano, E., Fink, C. W., Fouts, K., Fritts, M., Gerbier, G., Germond, R., Ghaith, M., Golwala, S. R., Hall, J., Hassan, N., Hines, B. A., Hollister, M. I., Hong, Z., Hoppe, E. W., Hsu, L., Huber, M. E., Iyer, V., Jastram, A., Kashyap, V. K. S., Kelsey, M. H., Kubik, A., Kurinsky, N. A., Lawrence, R. E., Lee, M., Li, A., Liu, J., Liu, Y., Loer, B., Asamar, E. Lopez, Lukens, P., MacFarlane, D. B., Mahapatra, R., Mandic, V., Mast, N., Mayer, A. J., Theenhausen, H. Meyer zu, Michaud, É., Michielin, E., Mirabolfathi, N., Mohanty, B., Nagorny, S., Nelson, J., Neog, H., Novati, V., Orrell, J. L., Osborne, M. D., Oser, S. M., Page, W. A., Partridge, R., Pedreros, D. S., Podviianiuk, R., Ponce, F., Poudel, S., Pradeep, A., Pyle, M., Rau, W., Reid, E., Ren, R., Reynolds, T., Roberts, A., Robinson, A. E., Saab, T., Sadoulet, B., Saikia, I., Sander, J., Sattari, A., Schmidt, B., Schnee, R. W., Scorza, S., Serfass, B., Poudel, S. S., Sincavage, D. J., Stanford, C., Street, J., Sun, H., Thasrawala, F. K., Toback, D., Underwood, R., Verma, S., Villano, A. N., von Krosigk, B., Watkins, S. L., Wen, O., Williams, Z., Wilson, M. J., Winchell, J., Wykoff, K., Yellin, S., Young, B. A., Yu, T. C., Zatschler, B., Zatschler, S., Zaytsev, A., Zhang, E., Zheng, L., and Zuber, S.
Subjects: High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics, Physics - Instrumentation and Detectors
Abstract: Recent experiments searching for sub-GeV/$c^2$ dark matter have observed event excesses close to their respective energy thresholds. Although specific to the individual technologies, the measured excess event rates have been consistently reported at or below event energies of a few-hundred eV, or with charges of a few electron-hole pairs. In the present work, we operated a 1-gram silicon SuperCDMS-HVeV detector at three voltages across the crystal (0 V, 60 V and 100 V). The 0 V data show an excess of events in the tens of eV region. Despite this event excess, we demonstrate the ability to set a competitive exclusion limit on the spin-independent dark matter--nucleon elastic scattering cross section for dark matter masses of $\mathcal{O}(100)$ MeV/$c^2$, enabled by operation of the detector at 0 V potential and achievement of a very low $\mathcal{O}(10)$ eV threshold for nuclear recoils. Comparing the data acquired at 0 V, 60 V and 100 V potentials across the crystal, we investigated possible sources of the unexpected events observed at low energy. The data indicate that the dominant contribution to the excess is consistent with a hypothesized luminescence from the printed circuit boards used in the detector holder.
Published: 2022
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13. A Strategy for Low-Mass Dark Matter Searches with Cryogenic Detectors in the SuperCDMS SNOLAB Facility

Author: SuperCDMS Collaboration, Albakry, M. F., Alkhatib, I., Amaral, D. W. P., Aralis, T., Aramaki, T., Arnquist, I. J., Langroudy, I. Ataee, Azadbakht, E., Banik, S., Bathurst, C., Bauer, D. A., Bhattacharyya, R., Brink, P. L., Bunker, R., Cabrera, B., Calkins, R., Cameron, R. A., Cartaro, C., Cerdeno, D. G., Chang, Y. -Y., Chaudhuri, M., Chen, R., Chott, N., Cooley, J., Coombes, H., Corbett, J., Cushman, P., De Brienne, F., Dharani, S., di Vacri, M. L., Diamond, M. D., Fascione, E., Figueroa-Feliciano, E., Fink, C. W., Fouts, K., Fritts, M., Gerbier, G., Germond, R., Ghaith, M., Golwala, S. R., Hall, J., Hassan, N., Hines, B. A., Hollister, M. I., Hong, Z., Hoppe, E. W., Hsu, L., Huber, M. E., Iyer, V., Jastram, A., Kashyap, V. K. S., Kelsey, M. H., Kubik, A., Kurinsky, N. A., Lawrence, R. E., Lee, M., Li, A., Liu, J., Liu, Y., Loer, B., Lukens, P., MacFarlane, D. B., Mahapatra, R., Mandic, V., Mast, N., Mayer, A. J., Theenhausen, H. Meyer zu, Michaud, E., Michielin, E., Mirabolfathi, N., Mohanty, B., Nagorny, S., Nelson, J., Neog, H., Novati, V., Orrell, J. L., Osborne, M. D., Oser, S. M., Page, W. A., Partridge, R., Pedreros, D. S., Podviianiuk, R., Ponce, F., Poudel, S., Pradeep, A., Pyle, M., Rau, W., Reid, E., Ren, R., Reynolds, T., Roberts, A., Robinson, A. E., Saab, T., Sadoulet, B., Saikia, I., Sander, J., Sattari, A., Schmidt, B., Schnee, R. W., Scorza, S., Serfass, B., Poudel, S. S., Sincavage, D. J., Stanford, C., Street, J., Sun, H., Thasrawala, F. K., Toback, D., Underwood, R., Verma, S., Villano, A. N., von Krosigk, B., Watkins, S. L., Wen, O., Williams, Z., Wilson, M. J., Winchell, J., Wyko, K., Yellin, S., Young, B. A., Yu, T. C., Zatschler, B., Zatschler, S., Zaytsev, A., Zhang, E., Zheng, L., and Zuber, S.
Subjects: Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment, Nuclear Experiment
Abstract: The SuperCDMS Collaboration is currently building SuperCDMS SNOLAB, a dark matter search focused on nucleon-coupled dark matter in the 1-5 GeV/c$^2$ mass range. Looking to the future, the Collaboration has developed a set of experience-based upgrade scenarios, as well as novel directions, to extend the search for dark matter using the SuperCDMS technology in the SNOLAB facility. The experienced-based scenarios are forecasted to probe many square decades of unexplored dark matter parameter space below 5 GeV/c$^2$, covering over 6 decades in mass: 1-100 eV/c$^2$ for dark photons and axion-like particles, 1-100 MeV/c$^2$ for dark-photon-coupled light dark matter, and 0.05-5 GeV/c$^2$ for nucleon-coupled dark matter. They will reach the neutrino fog in the 0.5-5 GeV/c$^2$ mass range and test a variety of benchmark models and sharp targets. The novel directions involve greater departures from current SuperCDMS technology but promise even greater reach in the long run, and their development must begin now for them to be available in a timely fashion. The experienced-based upgrade scenarios rely mainly on dramatic improvements in detector performance based on demonstrated scaling laws and reasonable extrapolations of current performance. Importantly, these improvements in detector performance obviate significant reductions in background levels beyond current expectations for the SuperCDMS SNOLAB experiment. Given that the dominant limiting backgrounds for SuperCDMS SNOLAB are cosmogenically created radioisotopes in the detectors, likely amenable only to isotopic purification and an underground detector life-cycle from before crystal growth to detector testing, the potential cost and time savings are enormous and the necessary improvements much easier to prototype., Comment: contribution to Snowmass 2021; v2 updated (assorted corrections and improvements to forecasts) October 2022; v3 updated (corrected SuperCDMS SNOLAB sensitivity curves in upgrade forecast plots in body of text) April 2023
Published: 2022

14. Ionization yield measurement in a germanium CDMSlite detector using photo-neutron sources

Author: SuperCDMS Collaboration, Albakry, M. F., Alkhatib, I., Amaral, D. W. P., Aralis, T., Aramaki, T., Arnquist, I. J., Langroudy, I. Ataee, Azadbakht, E., Banik, S., Bathurst, C., Bauer, D. A., Bezerra, L. V. S., Bhattacharyya, R., Bowles, M. A., Brink, P. L., Bunker, R., Cabrera, B., Calkins, R., Cameron, R. A., Cartaro, C., Cerdeño, D. G., Chang, Y. -Y., Chaudhuri, M., Chen, R., Chott, N., Cooley, J., Coombes, H., Corbett, J., Cushman, P., De Brienne, F., di Vacri, M. L., Diamond, M. D., Fascione, E., Figueroa-Feliciano, E., Fink, C. W., Fouts, K., Fritts, M., Gerbier, G., Germond, R., Ghaith, M., Golwala, S. R., Hall, J., Hines, B. A., Hollister, M. I., Hong, Z., Hoppe, E. W., Hsu, L., Huber, M. E., Iyer, V., Jastram, A., Kashyap, V. K. S., Kelsey, M. H., Kubik, A., Kurinsky, N. A., Lawrence, R. E., Lee, M., Li, A., Liu, J., Liu, Y., Loer, B., Lukens, P., MacDonell, D., MacFarlane, D. B., Mahapatra, R., Mandic, V., Mast, N., Mayer, A. J., Theenhausen, H. Meyer zu, Michaud, É., Michielin, E., Mirabolfathi, N., Mohanty, B., Mendoza, J. D. Morales, Nagorny, S., Nelson, J., Neog, H., Novati, V., Orrell, J. L., Osborne, M. D., Oser, S. M., Page, W. A., Partridge, R., Pedreros, D. S., Podviianiuk, R., Ponce, F., Poudel, S., Pradeep, A., Pyle, M., Rau, W., Reid, E., Ren, R., Reynolds, T., Roberts, A., Robinson, A. E., Saab, T., Sadoulet, B., Saikia, I., Sander, J., Sattari, A., Scarff, A., Schmidt, B., Schnee, R. W., Scorza, S., Serfass, B., Sincavage, D. J., Stanford, C., Street, J., Thasrawala, F. K., Toback, D., Underwood, R., Verma, S., Villano, A. N., von Krosigk, B., Watkins, S. L., Wen, O., Williams, Z., Wilson, M. J., Winchell, J., Wykoff, K., Yellin, S., Young, B. A., Yu, T. C., Zatschler, B., Zatschler, S., Zaytsev, A., Zhang, E., Zheng, L., and Zuber, S.
Subjects: Physics - Instrumentation and Detectors
Abstract: Two photo-neutron sources, $^{88}$Y$^{9}$Be and $^{124}$Sb$^{9}$Be, have been used to investigate the ionization yield of nuclear recoils in the CDMSlite germanium detectors by the SuperCDMS collaboration. This work evaluates the yield for nuclear recoil energies between 1 keV and 7 keV at a temperature of $\sim$ 50 mK. We use a Geant4 simulation to model the neutron spectrum assuming a charge yield model that is a generalization of the standard Lindhard model and consists of two energy dependent parameters. We perform a likelihood analysis using the simulated neutron spectrum, modeled background, and experimental data to obtain the best fit values of the yield model. The ionization yield between recoil energies of 1 keV and 7 keV is shown to be significantly lower than predicted by the standard Lindhard model for germanium. There is a general lack of agreement among different experiments using a variety of techniques studying the low-energy range of the nuclear recoil yield, which is most critical for interpretation of direct dark matter searches. This suggests complexity in the physical process that many direct detection experiments use to model their primary signal detection mechanism and highlights the need for further studies to clarify underlying systematic effects that have not been well understood up to this point.
Published: 2022
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15. EXCESS workshop: Descriptions of rising low-energy spectra

Author: Adari, P., Aguilar-Arevalo, A., Amidei, D., Angloher, G., Armengaud, E., Augier, C., Balogh, L., Banik, S., Baxter, D., Beaufort, C., Beaulieu, G., Belov, V., Gal, Y. Ben, Benato, G., Benoît, A., Bento, A., Bergé, L., Bertolini, A., Bhattacharyya, R., Billard, J., Bloch, I. M., Botti, A., Breier, R., Bres, G., Bret, J-. L., Broniatowski, A., Brossard, A., Bucci, C., Bunker, R., Cababie, M., Calvo, M., Camus, P., Cancelo, G., Canonica, L., Cappella, F., Cardani, L., Caron, J. -F., Casali, N., del Castello, G., Cazes, A., Cerulli, R., Vergara, B. A. Cervantes, Chaize, D., Chapellier, M., Chaplinsky, L., Charlieux, F., Chaudhuri, M., Chavarria, A. E., Chemin, G., Chen, R., Chen, H., Chierchie, F., Colantoni, I., Colas, J., Cooley, J., Coquillat, J. -M., Corcoran, E. C., Crawford, S., Crisler, M., Cruciani, A., Cushman, P., D'Addabbo, A., D'Olivo, J. C., Dastgheibi-Fard, A., De Jésus, M., Deng, Y., Dent, J. B., Depaoli, E. L., Dering, K., Dharani, S., Di Lorenzo, S., Drlica-Wagner, A., Dumoulin, L., Durnford, D., Dutta, B., Einfalt, L., Erb, A., Erhart, A., Essig, R., Estrada, J., Etzion, E., Exshaw, O., Favela-Perez, F., Feilitzsch, F. v., Moroni, G. Fernandez, Iachellini, N. Ferreiro, Ferriol, S., Fichtinger, S., Figueroa-Feliciano, E., Filippini, J. -B., Filosofov, D., Formaggio, J. A., Friedl, M., Fuard, S., Fuchs, D., Fuss, A., Gaïor, R., Garai, A., Garrah, C., Gascon, J., Gerbier, G., Ghaith, M., Ghete, V. M., Gift, D., Giomataris, I., Giroux, G., Giuliani, A., Gorel, P., Gorla, P., Goupy, C., Goupy, J., Goy, C., Gros, M., Gros, P., Guardincerri, Y., Guerin, C., Guidi, V., Guillaudin, O., Gupta, S., Guy, E., Harrington, P., Hauff, D., Heine, S. T., Hertel, S. A., Holland, S. E., Hong, Z., Hoppe, E. W., Hossbach, T. W., Ianigro, J. -C., Iyer, V., Jastram, A., Ješkovský, M., Jin, Y., Jochum, J., Johnston, J. P., Juillard, A., Karaivanov, D., Kashyap, V., Katsioulas, I., Kazarcev, S., Kaznacheeva, M., Kelly, F., Kilminster, B., Kinast, A., Klinkenberg, L., Kluck, H., Knights, P., Korn, Y., Kraus, H., von Krosigk, B., Kubik, A., Kurinsky, N. A., Lamblin, J., Langenkämper, A., Langrock, S., Lasserre, T., Lattaud, H., Lautridou, P., Lawson, I., Lee, S. J., Lee, M., Letessier-Selvon, A., Lhuillier, D., Li, M., Lin, Y. -T., Lubashevskiy, A., Mahapatra, R., Maludze, S., Mancuso, M., Manthos, I., Marini, L., Marnieros, S., Martin, R. D., Matalon, A., Matthews, J., Mauri, B., Mayer, D. W., Mazzolari, A., Mazzucato, E., Theenhausen, H. Meyer zu, Michielin, E., Minet, J., Mirabolfathi, N., Mirbach, K. v., Misiak, D., Mitra, P., Mocellin, J-. L., Mohanty, B., Mokina, V., Mols, J. -P., Monfardini, A., Mounier, F., Munagavalasa, S., Muraz, J. -F., Navick, X. -F., Neep, T., Neog, H., Neyrial, H., Nikolopoulos, K., Nilima, A., Nones, C., Novati, V., O'Brien, P., Oberauer, L., Olivieri, E., Olmi, M., Onillon, A., Oriol, C., Orly, A., Orrell, J. L., Ortmann, T., Overman, C. T., Pagliarone, C., Palušová, V., Pari, P., Patel, P. K., Pattavina, L., Petricca, F., Piers, A., Pinckney, H. D., Piro, M. -C., Platt, M., Poda, D., Ponomarev, D., Potzel, W., Povinec, P., Pröbst, F., Privitera, P., Pucci, F., Ramanathan, K., Real, J. -S., Redon, T., Reindl, F., Ren, R., Robert, A., Da Rocha, J., Rodrigues, D., Rogly, R., Rothe, J., Rowe, N., Rozov, S., Rozova, I., Saab, T., Saffold, N., Salagnac, T., Sander, J., Sanglard, V., Santos, D., Sarkis, Y., Savu, V., Savvidis, G., Savvidis, I., Schönert, S., Schäffner, K., Schermer, N., Schieck, J., Schmidt, B., Schmiedmayer, D., Schwertner, C., Scola, L., Settimo, M., Shevchik, Ye., Sibille, V., Sidelnik, I., Singal, A., Smida, R., Haro, M. Sofo, Soldner, T., Stachurska, J., Stahlberg, M., Stefanazzi, L., Stodolsky, L., Strandhagen, C., Strauss, R., Stutz, A., Thomas, R., Thompson, A., Tiffenberg, J., Tomei, C., Traina, M., Uemura, S., Usherov, I., Vagneron, L., Van De Pontseele, W., Fernandez, F. A. Vazquez de Sola, Vidal, M., Vignati, M., Virto, A. L., Vivier, M., Volansky, T., Wagner, V., Wagner, F., Walker, J., Ward, R., Watkins, S. L., Wex, A., Willers, M., Wilson, M. J., Winslow, L., Yakushev, E., Yu, T. -T., Zampaolo, M., Zaytsev, A., Zema, V., Zinatulina, D., and Zolotarova, A.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract: Many low-threshold experiments observe sharply rising event rates of yet unknown origins below a few hundred eV, and larger than expected from known backgrounds. Due to the significant impact of this excess on the dark matter or neutrino sensitivity of these experiments, a collective effort has been started to share the knowledge about the individual observations. For this, the EXCESS Workshop was initiated. In its first iteration in June 2021, ten rare event search collaborations contributed to this initiative via talks and discussions. The contributing collaborations were CONNIE, CRESST, DAMIC, EDELWEISS, MINER, NEWS-G, NUCLEUS, RICOCHET, SENSEI and SuperCDMS. They presented data about their observed energy spectra and known backgrounds together with details about the respective measurements. In this paper, we summarize the presented information and give a comprehensive overview of the similarities and differences between the distinct measurements. The provided data is furthermore publicly available on the workshop's data repository together with a plotting tool for visualization., Comment: 44 pages, 20 figures; Editors: A. Fuss, M. Kaznacheeva, F. Reindl, F. Wagner; updated copyright statements and funding information
Published: 2022
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16. Study on interface characteristics and electron spin manipulation of two-dimensional [formula omitted] (001) heterostructures

Author: Xu, Yimin and Ren, R.
Published: 2024
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17. Compression Mechanics for Carbon-Fiberreinforced Epoxy Resin Composites Under Inplane and Out-Of-Plane Quasi-Static and Dynamic Loadings

Author: Zhao, C. F., Ren, R., Sun, C. B., Ren, J., Zhong, J. L., and Zhang, Z. D.
Published: 2023
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18. Design and Characterization of a Phonon-Mediated Cryogenic Particle Detector with an eV-Scale Threshold and 100 keV-Scale Dynamic Range

Author: Ren, R., Bathurst, C., Chang, Y. Y., Chen, R., Fink, C. W., Hong, Z., Kurinsky, N. A., Mast, N., Mishra, N., Novati, V., Spahn, G., Theenhausen, H. Meyer zu, Watkins, S. L., Williams, Z., Wilson, M. J., Zaytsev, A., Bauer, D., Bunker, R., Figueroa-Feliciano, E., Hollister, M., Hsu, L., Lukens, P., Mahapatra, R., Mirabolfathi, N., Nebolsky, B., Platt, M., Ponce, F., Pyle, M., Reynolds, T., and Saab, T.
Subjects: Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract: We present the design and characterization of a cryogenic phonon-sensitive 1-gram Si detector exploiting the Neganov-Trofimov-Luke effect to detect single-charge excitations. This device achieved 2.65(2)~eV phonon energy resolution when operated without a voltage bias across the crystal and a corresponding charge resolution of 0.03 electron-hole pairs at 100~V bias. With a continuous-readout data acquisition system and an offline optimum-filter trigger, we obtain a 9.2~eV threshold with a trigger rate of the order of 20~Hz. The detector's energy scale is calibrated up to 120~keV using an energy estimator based on the pulse area. The high performance of this device allows its application to different fields where excellent energy resolution, low threshold, and large dynamic range are required, including dark matter searches, precision measurements of coherent neutrino-nucleus scattering, and ionization yield measurements., Comment: 17 pages, 12 figures, submitted to PRD
Published: 2020
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19. Constraints on Lightly Ionizing Particles from CDMSlite

Author: SuperCDMS Collaboration, Alkhatib, I., Amaral, D. W. P., Aralis, T., Aramaki, T., Arnquist, I. J., Langroudy, I. Ataee, Azadbakht, E., Banik, S., Barker, D., Bathurst, C., Bauer, D. A., Bezerra, L. V. S., Bhattacharyya, R., Bowles, M. A., Brink, P. L., Bunker, R., Cabrera, B., Calkins, R., Cameron, R. A., Cartaro, C., Cerdeño, D. G., Chang, Y. -Y., Chaudhuri, M., Chen, R., Chott, N., Cooley, J., Coombes, H., Corbett, J., Cushman, P., De Brienne, F., di Vacri, M. L., Diamond, M. D., Fascione, E., Figueroa-Feliciano, E., Fink, C. W., Fouts, K., Fritts, M., Gerbier, G., Germond, R., Ghaith, M., Golwala, S. R., Harris, H. R., Hines, B. A., Hollister, M. I., Hong, Z., Hoppe, E. W., Hsu, L., Huber, M. E., Iyer, V., Jardin, D., Jastram, A., Kashyap, V. K. S., Kelsey, M. H., Kubik, A., Kurinsky, N. A., Lawrence, R. E., Li, A., Loer, B., Asamar, E. Lopez, Lukens, P., MacFarlane, D. B., Mahapatra, R., Mandic, V., Mast, N., Mayer, A. J., Theenhausen, H. Meyer zu, Michaud, É. M., Michielin, E., Mirabolfathi, N., Mohanty, B., Mendoza, J. D. Morales, Nagorny, S., Nelson, J., Neog, H., Novati, V., Orrell, J. L., Oser, S. M., Page, W. A., Partridge, R., Podviianiuk, R., Ponce, F., Poudel, S., Pradeep, A., Pyle, M., Rau, W., Reid, E., Ren, R., Reynolds, T., Roberts, A., Robinson, A. E., Saab, T., Sadoulet, B., Sander, J., Sattari, A., Schnee, R. W., Scorza, S., Serfass, B., Sincavage, D. J., Stanford, C., Street, J., Toback, D., Underwood, R., Verma, S., Villano, A. N., von Krosigk, B., Watkins, S. L., Wilson, J. S., Wilson, M. J., Winchell, J., Wright, D. H., Yellin, S., Young, B. A., Yu, T. C., Zhang, E., Zhang, H. G., Zhao, X., and Zheng, L.
Subjects: High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Phenomenology, Physics - Instrumentation and Detectors
Abstract: The Cryogenic Dark Matter Search low ionization threshold experiment (CDMSlite) achieved efficient detection of very small recoil energies in its germanium target, resulting in sensitivity to Lightly Ionizing Particles (LIPs) in a previously unexplored region of charge, mass, and velocity parameter space. We report first direct-detection limits calculated using the optimum interval method on the vertical intensity of cosmogenically-produced LIPs with an electric charge smaller than $e/(3\times10^5$), as well as the strongest limits for charge $\leq e/160$, with a minimum vertical intensity of $1.36\times10^{-7}$\,cm$^{-2}$s$^{-1}$sr$^{-1}$ at charge $e/160$. These results apply over a wide range of LIP masses (5\,MeV/$c^2$ to 100\,TeV/$c^2$) and cover a wide range of $\beta\gamma$ values (0.1 -- $10^6$), thus excluding non-relativistic LIPs with $\beta\gamma$ as small as 0.1 for the first time.
Published: 2020
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20. Constraints on Lightly Ionizing Particles from CDMSlite

Author: Alkhatib, I, Amaral, DWP, Aralis, T, Aramaki, T, Arnquist, IJ, Langroudy, I Ataee, Azadbakht, E, Banik, S, Barker, D, Bathurst, C, Bauer, DA, Bezerra, LVS, Bhattacharyya, R, Bowles, MA, Brink, PL, Bunker, R, Cabrera, B, Calkins, R, Cameron, RA, Cartaro, C, Cerdeño, DG, Chang, Y-Y, Chaudhuri, M, Chen, R, Chott, N, Cooley, J, Coombes, H, Corbett, J, Cushman, P, De Brienne, F, di Vacri, ML, Diamond, MD, Fascione, E, Figueroa-Feliciano, E, Fink, CW, Fouts, K, Fritts, M, Gerbier, G, Germond, R, Ghaith, M, Golwala, SR, Harris, HR, Hines, BA, Hollister, MI, Hong, Z, Hoppe, EW, Hsu, L, Huber, ME, Iyer, V, Jardin, D, Jastram, A, Kashyap, VKS, Kelsey, MH, Kubik, A, Kurinsky, NA, Lawrence, RE, Li, A, Loer, B, Asamar, E Lopez, Lukens, P, MacFarlane, DB, Mahapatra, R, Mandic, V, Mast, N, Mayer, AJ, Theenhausen, H Meyer zu, Michaud, ÉM, Michielin, E, Mirabolfathi, N, Mohanty, B, Mendoza, JD Morales, Nagorny, S, Nelson, J, Neog, H, Novati, V, Orrell, JL, Oser, SM, Page, WA, Partridge, R, Podviianiuk, R, Ponce, F, Poudel, S, Pradeep, A, Pyle, M, Rau, W, Reid, E, Ren, R, Reynolds, T, Roberts, A, Robinson, AE, Saab, T, Sadoulet, B, Sander, J, Sattari, A, Schnee, RW, Scorza, S, Serfass, B, Sincavage, DJ, Stanford, C, and Street, J
Subjects: SuperCDMS Collaboration, Mathematical Sciences, Physical Sciences, Engineering, General Physics
Abstract: The Cryogenic Dark Matter Search low ionization threshold experiment (CDMSlite) achieved efficient detection of very small recoil energies in its germanium target, resulting in sensitivity to lightly ionizing particles (LIPs) in a previously unexplored region of charge, mass, and velocity parameter space. We report first direct-detection limits calculated using the optimum interval method on the vertical intensity of cosmogenically produced LIPs with an electric charge smaller than e/(3×10^{5}), as well as the strongest limits for charge ≤e/160, with a minimum vertical intensity of 1.36×10^{-7} cm^{-2} s^{-1} sr^{-1} at charge e/160. These results apply over a wide range of LIP masses (5 MeV/c^{2} to 100 TeV/c^{2}) and cover a wide range of βγ values (0.1-10^{6}), thus excluding nonrelativistic LIPs with βγ as small as 0.1 for the first time.
Published: 2021

21. Light Dark Matter Search with a High-Resolution Athermal Phonon Detector Operated above Ground

Author: Alkhatib, I, Amaral, DWP, Aralis, T, Aramaki, T, Arnquist, IJ, Langroudy, I Ataee, Azadbakht, E, Banik, S, Barker, D, Bathurst, C, Bauer, DA, Bezerra, LVS, Bhattacharyya, R, Binder, T, Bowles, MA, Brink, PL, Bunker, R, Cabrera, B, Calkins, R, Cameron, RA, Cartaro, C, Cerdeño, DG, Chang, Y-Y, Chaudhuri, M, Chen, R, Chott, N, Cooley, J, Coombes, H, Corbett, J, Cushman, P, De Brienne, F, di Vacri, ML, Diamond, MD, Fascione, E, Figueroa-Feliciano, E, Fink, CW, Fouts, K, Fritts, M, Gerbier, G, Germond, R, Ghaith, M, Golwala, SR, Harris, HR, Herbert, N, Hines, BA, Hollister, MI, Hong, Z, Hoppe, EW, Hsu, L, Huber, ME, Iyer, V, Jardin, D, Jastram, A, Kashyap, VKS, Kelsey, MH, Kubik, A, Kurinsky, NA, Lawrence, RE, Li, A, Loer, B, Asamar, E Lopez, Lukens, P, MacDonell, D, MacFarlane, DB, Mahapatra, R, Mandic, V, Mast, N, Mayer, AJ, Theenhausen, H Meyer zu, Michaud, ÉM, Michielin, E, Mirabolfathi, N, Mohanty, B, Mendoza, JD Morales, Nagorny, S, Nelson, J, Neog, H, Novati, V, Orrell, JL, Oser, SM, Page, WA, Pakarha, P, Partridge, R, Podviianiuk, R, Ponce, F, Poudel, S, Pyle, M, Rau, W, Reid, E, Ren, R, Reynolds, T, Roberts, A, Robinson, AE, Saab, T, Sadoulet, B, Sander, J, Sattari, A, Schnee, RW, Scorza, S, and Serfass, B
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, SuperCDMS Collaboration, Mathematical Sciences, Engineering, General Physics, Mathematical sciences, Physical sciences
Abstract: We present limits on spin-independent dark matter-nucleon interactions using a 10.6 g Si athermal phonon detector with a baseline energy resolution of σ_{E}=3.86±0.04(stat)_{-0.00}^{+0.19}(syst) eV. This exclusion analysis sets the most stringent dark matter-nucleon scattering cross-section limits achieved by a cryogenic detector for dark matter particle masses from 93 to 140 MeV/c^{2}, with a raw exposure of 9.9 g d acquired at an above-ground facility. This work illustrates the scientific potential of detectors with athermal phonon sensors with eV-scale energy resolution for future dark matter searches.
Published: 2021

22. Light Dark Matter Search with a High-Resolution Athermal Phonon Detector Operated Above Ground

Author: Alkhatib, I., Amaral, D. W. P., Aralis, T., Aramaki, T., Arnquist, I. J., Langroudy, I. Ataee, Azadbakht, E., Banik, S., Barker, D., Bathurst, C., Bauer, D. A., Bezerra, L. V. S., Bhattacharyya, R., Binder, T., Bowles, M. A., Brink, P. L., Bunker, R., Cabrera, B., Calkins, R., Cameron, R. A., Cartaro, C., Cerdeño, D. G., Chang, Y. -Y., Chaudhuri, M., Chen, R., Chott, N., Cooley, J., Coombes, H., Corbett, J., Cushman, P., De Brienne, F., di Vacri, M. L., Diamond, M. D., Fascione, E., Figueroa-Feliciano, E., Fink, C. W., Fouts, K., Fritts, M., Gerbier, G., Germond, R., Ghaith, M., Golwala, S. R., Harris, H. R., Herbert, N., Hines, B. A., Hollister, M. I., Hong, Z., Hoppe, E. W., Hsu, L., Huber, M. E., Iyer, V., Jardin, D., Jastram, A., Kashyap, V. K. S., Kelsey, M. H., Kubik, A., Kurinsky, N. A., Lawrence, R. E., Li, A., Loer, B., Asamar, E. Lopez, Lukens, P., MacDonell, D., MacFarlane, D. B., Mahapatra, R., Mandic, V., Mast, N., Mayer, A. J., Theenhausen, H. Meyer zu, Michaud, É. M., Michielin, E., Mirabolfathi, N., Mohanty, B., Mendoza, J. D. Morales, Nagorny, S., Nelson, J., Neog, H., Novati, V., Orrell, J. L., Oser, S. M., Page, W. A., Pakarha, P., Partridge, R., Podviianiuk, R., Ponce, F., Poudel, S., Pyle, M., Rau, W., Reid, E., Ren, R., Reynolds, T., Roberts, A., Robinson, A. E., Saab, T., Sadoulet, B., Sander, J., Sattari, A., Schnee, R. W., Scorza, S., Serfass, B., Sincavage, D. J., Stanford, C., Street, J., Toback, D., Underwood, R., Verma, S., Villano, A. N., von Krosigk, B., Watkins, S. L., Wills, L., Wilson, J. S., Wilson, M. J., Winchell, J., Wright, D. H., Yellin, S., Young, B. A., Yu, T. C., Zhang, E., Zhang, H. G., Zhao, X., Zheng, L., Camilleri, J., Kolomensky, Yu. G., and Zuber, S.
Subjects: High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics, Physics - Instrumentation and Detectors
Abstract: We present limits on spin-independent dark matter-nucleon interactions using a $10.6$ $\mathrm{g}$ Si athermal phonon detector with a baseline energy resolution of $\sigma_E=3.86 \pm 0.04$ $(\mathrm{stat.})^{+0.19}_{-0.00}$ $(\mathrm{syst.})$ $\mathrm{eV}$. This exclusion analysis sets the most stringent dark matter-nucleon scattering cross-section limits achieved by a cryogenic detector for dark matter particle masses from $93$ to $140$ $\mathrm{MeV}/c^2$, with a raw exposure of $9.9$ $\mathrm{g}\cdot\mathrm{d}$ acquired at an above-ground facility. This work illustrates the scientific potential of detectors with athermal phonon sensors with eV-scale energy resolution for future dark matter searches., Comment: 7 pages, 4 figures, this version includes ancillary files from official data release
Published: 2020
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23. Constraints on low-mass, relic dark matter candidates from a surface-operated SuperCDMS single-charge sensitive detector

Author: SuperCDMS Collaboration, Amaral, D. W., Aralis, T., Aramaki, T., Arnquist, I. J., Azadbakht, E., Banik, S., Barker, D., Bathurst, C., Bauer, D. A., Bezerra, L. V. S., Bhattacharyya, R., Binder, T., Bowles, M. A., Brink, P. L., Bunker, R., Cabrera, B., Calkins, R., Cameron, R. A., Cartaro, C., Cerdeño, D. G., Chang, Y. -Y., Chen, R., Chott, N., Cooley, J., Coombes, H., Corbett, J., Cushman, P., De Brienne, F., di Vacri, M. L., Diamond, M. D., Fascione, E., Figueroa-Feliciano, E., Fink, C. W., Fouts, K., Fritts, M., Gerbier, G., Germond, R., Ghaith, M., Golwala, S. R., Harris, H. R., Herbert, N., Hines, B. A., Hollister, M. I., Hong, Z., Hoppe, E. W., Hsu, L., Huber, M. E., Iyer, V., Jardin, D., Jastram, A., Kelsey, M. H., Kubik, A., Kurinsky, N. A., Lawrence, R. E., Li, A., Loer, B., Asamar, E. Lopez, Lukens, P., MacDonell, D., MacFarlane, D. B., Mahapatra, R., Mandic, V., Mast, N., Mayer, A. J., Michaud, É. M., Michielin, E., Mirabolfathi, N., Mohanty, B., Mendoza, J. D. Morales, Nagorny, S., Nelson, J., Neog, H., Novati, V., Orrell, J. L., Oser, S. M., Page, W. A., Pakarha, P., Partridge, R., Podviianiuk, R., Ponce, F., Poudel, S., Pyle, M., Rau, W., Reid, E., Ren, R., Reynolds, T., Roberts, A., Robinson, A. E., Rogers, H. E., Saab, T., Sadoulet, B., Sander, J., Sattari, A., Schnee, R. W., Scorza, S., Serfass, B., Sincavage, D. J., Stanford, C., Stein, M., Street, J., Toback, D., Underwood, R., Verma, S., Villano, A. N., von Krosigk, B., Watkins, S. L., Wills, L., Wilson, J. S., Wilson, M. J., Winchell, J., Wright, D. H., Yellin, S., Young, B. A., Yu, T. C., Zhang, E., Zhang, H. G., Zhao, X., and Zheng, L.
Subjects: High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics, Physics - Instrumentation and Detectors
Abstract: This article presents an analysis and the resulting limits on light dark matter inelastically scattering off of electrons, and on dark photon and axion-like particle absorption, using a second-generation SuperCDMS high-voltage eV-resolution detector. The 0.93 gram Si detector achieved a 3 eV phonon energy resolution; for a detector bias of 100 V, this corresponds to a charge resolution of 3% of a single electron-hole pair. The energy spectrum is reported from a blind analysis with 1.2 gram-days of exposure acquired in an above-ground laboratory. With charge carrier trapping and impact ionization effects incorporated into the dark matter signal models, the dark matter-electron cross section $\bar{\sigma}_{e}$ is constrained for dark matter masses from 0.5--$10^{4} $MeV$/c^{2}$; in the mass range from 1.2--50 eV$/c^{2}$ the dark photon kinetic mixing parameter $\varepsilon$ and the axioelectric coupling constant $g_{ae}$ are constrained. The minimum 90% confidence-level upper limits within the above mentioned mass ranges are $\bar{\sigma}_{e}\,=\,8.7\times10^{-34}$ cm$^{2}$, $\varepsilon\,=\,3.3\times10^{-14}$, and $g_{ae}\,=\,1.0\times10^{-9}$., Comment: 5 pages + title and references, 3 figures and 1 table
Published: 2020
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24. Constraints on dark photons and axion-like particles from SuperCDMS Soudan

Author: SuperCDMS Collaboration, Aralis, T., Aramaki, T., Arnquist, I. J., Azadbakht, E., Baker, W., Banik, S., Barker, D., Bathurst, C., Bauer, D. A., Bezerra, L. V. S, Bhattacharyya, R., Binder, T., Bowles, M. A., Brink, P. L., Bunker, R., Cabrera, B., Calkins, R., Cameron, R. A., Cartaro, C., Cerdeño, D. G., Chang, Y. -Y., Cooley, J., Coombes, H., Corbett, J., Cornell, B., Cushman, P., De Brienne, F., di Vacri, M. L., Diamond, M. D., Fascione, E., Figueroa-Feliciano, E., Fink, C. W., Fouts, K., Fritts, M., Gerbier, G., Germond, R., Ghaith, M., Golwala, S. R., Harris, H. R., Herbert, N., Hines, B. A., Hollister, M. I., Hong, Z., Hoppe, E. W., Hsu, L., Huber, M. E., Iyer, V., Jardin, D., Jastram, A., Kelsey, M. H., Kennedy, A., Kubik, A., Kurinsky, N. A., Lawrence, R. E., Li, A., Loer, B., Asamar, E. Lopez, Lukens, P., MacDonell, D., MacFarlane, D. B., Mahapatra, R., Mandic, V., Mast, N., Michaud, É. M., Michielin, E., Mirabolfathi, N., Mohanty, B., Mendoza, J. D. Morales, Nagorny, S., Nelson, J., Neog, H., Orrell, J. L., Oser, S. M., Page, W. A., Pakarha, P., Partridge, R., Podviianiuk, R., Ponce, F., Poudel, S., Pyle, M., Rau, W., Ren, R., Reynolds, T., Roberts, A., Robinson, A. E., Rogers, H. E., Saab, T., Sadoulet, B., Sander, J., Toback, D., Underwood, R., Verma, S., Villano, A. N., von Krosigk, B., Watkins, S. L., Wills, L., Wilson, J. S., Wilson, M. J., Winchell, J., Wright, D. H., Yellin, S., Young, B. A., Yu, T. C., Zhang, E., Zhao, X., and Zheng, L.
Subjects: High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract: We present an analysis of electron recoils in cryogenic germanium detectors operated during the SuperCDMS Soudan experiment. The data are used to set new constraints on the axioelectric coupling of axion-like particles and the kinetic mixing parameter of dark photons, assuming the respective species constitutes all of the galactic dark matter. This study covers the mass range from 40 eV/$c^2$ to 500 eV/$c^2$ for both candidates, excluding previously untested parameter space for masses below ~1 keV/$c^2$. For the kinetic mixing of dark photons, values below $10^{-15}$ are reached for particle masses around 100 eV/$c^2$; for the axioelectric coupling of axion-like particles, values below $10^{-12}$ are reached for particles with masses in the range of a few-hundred eV/$c^2$., Comment: 14 pages, 10 figures, 1 page correction included with 3 figures
Published: 2019
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25. Saak Transform-Based Machine Learning for Light-Sheet Imaging of Cardiac Trabeculation

Author: Ding, Yichen, Gudapati, Varun, Lin, Ruiyuan, Fei, Yanan, Packard, Ren R Sevag, Song, Sibo, Chang, Chih-Chiang, Baek, Kyung In, Wang, Zhaoqiang, Roustaei, Mehrdad, Kuang, Dengfeng, Kuo, C-C Jay, and Hsiai, Tzung K
Subjects: Computer Vision and Multimedia Computation, Information and Computing Sciences, Engineering, Machine Learning, Biomedical Imaging, Cardiovascular, Bioengineering, Networking and Information Technology R&D (NITRD), Heart Disease, Algorithms, Heart, Image Processing, Computer-Assisted, Microscopy, Fluorescence, Neural Networks, Computer, Transforms, Image segmentation, Kernel, Feature extraction, Random forests, Neural networks, Biomedical optical imaging, machine learning, cardiology, principal component analysis, Artificial Intelligence and Image Processing, Biomedical Engineering, Electrical and Electronic Engineering, Biomedical engineering, Electronics, sensors and digital hardware, Computer vision and multimedia computation
Abstract: ObjectiveRecent advances in light-sheet fluorescence microscopy (LSFM) enable 3-dimensional (3-D) imaging of cardiac architecture and mechanics in toto. However, segmentation of the cardiac trabecular network to quantify cardiac injury remains a challenge.MethodsWe hereby employed "subspace approximation with augmented kernels (Saak) transform" for accurate and efficient quantification of the light-sheet image stacks following chemotherapy-treatment. We established a machine learning framework with augmented kernels based on the Karhunen-Loeve Transform (KLT) to preserve linearity and reversibility of rectification.ResultsThe Saak transform-based machine learning enhances computational efficiency and obviates iterative optimization of cost function needed for neural networks, minimizing the number of training datasets for segmentation in our scenario. The integration of forward and inverse Saak transforms can also serve as a light-weight module to filter adversarial perturbations and reconstruct estimated images, salvaging robustness of existing classification methods. The accuracy and robustness of the Saak transform are evident following the tests of dice similarity coefficients and various adversary perturbation algorithms, respectively. The addition of edge detection further allows for quantifying the surface area to volume ratio (SVR) of the myocardium in response to chemotherapy-induced cardiac remodeling.ConclusionThe combination of Saak transform, random forest, and edge detection augments segmentation efficiency by 20-fold as compared to manual processing.SignificanceThis new methodology establishes a robust framework for post light-sheet imaging processing, and creating a data-driven machine learning for automated quantification of cardiac ultra-structure.
Published: 2021

26. Constraints on dark photons and axionlike particles from the SuperCDMS Soudan experiment

Author: Aralis, T, Aramaki, T, Arnquist, IJ, Azadbakht, E, Baker, W, Banik, S, Barker, D, Bathurst, C, Bauer, DA, Bezerra, LVS, Bhattacharyya, R, Binder, T, Bowles, MA, Brink, PL, Bunker, R, Cabrera, B, Calkins, R, Cameron, RA, Cartaro, C, Cerdeño, DG, Chang, Y-Y, Cooley, J, Coombes, H, Corbett, J, Cornell, B, Cushman, P, De Brienne, F, di Vacri, ML, Diamond, MD, Fascione, E, Figueroa-Feliciano, E, Fink, CW, Fouts, K, Fritts, M, Gerbier, G, Germond, R, Ghaith, M, Golwala, SR, Harris, HR, Herbert, N, Hines, BA, Hollister, MI, Hong, Z, Hoppe, EW, Hsu, L, Huber, ME, Iyer, V, Jardin, D, Jastram, A, Kelsey, MH, Kennedy, A, Kubik, A, Kurinsky, NA, Lawrence, RE, Li, A, Loer, B, Asamar, E Lopez, Lukens, P, MacDonell, D, MacFarlane, DB, Mahapatra, R, Mandic, V, Mast, N, Michaud, ÉM, Michielin, E, Mirabolfathi, N, Mohanty, B, Mendoza, JD Morales, Nagorny, S, Nelson, J, Neog, H, Orrell, JL, Oser, SM, Page, WA, Pakarha, P, Partridge, R, Podviianiuk, R, Ponce, F, Poudel, S, Pyle, M, Rau, W, Ren, R, Reynolds, T, Roberts, A, Robinson, AE, Rogers, HE, Saab, T, Sadoulet, B, Sander, J, Schnee, RW, Scorza, S, Senapati, K, Serfass, B, Sincavage, DJ, Stanford, C, Stein, M, Street, J, Toback, D, Underwood, R, and Verma, S
Subjects: hep-ex, physics.ins-det, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Quantum Physics, Nuclear & Particles Physics
Abstract: We present an analysis of electron recoils in cryogenic germanium detectors operated during the SuperCDMS Soudan experiment. The data are used to set new constraints on the axioelectric coupling of axionlike particles and the kinetic mixing parameter of dark photons, assuming the respective species constitutes all of the galactic dark matter. This study covers the mass range from 40 eV/c2 to 500 keV/c2 for both candidates, excluding previously untested parameter space for masses below ∼1 keV/c2. For the kinetic mixing of dark photons, values below 10-15 are reached for particle masses around 100 eV/c2; for the axioelectric coupling of axionlike particles, values below 10-12 are reached for particles with masses in the range of a few-hundred eV/c2.
Published: 2020

27. In vitro and Intracellular Antibacterial Activity of Sudapyridine (WX-081) Against Tuberculosis

Author: Xiao H, Yu X, Shang Y, Ren R, Xue Y, Dong L, Zhao L, Jiang G, and Huang H
Subjects: tuberculosis, sudapyridine, bedaquiline, antibacterial activity, Infectious and parasitic diseases, RC109-216
Abstract: Hua Xiao,&ast; Xia Yu,&ast; Yuanyuan Shang, Ruyan Ren, Yi Xue, Lingling Dong, Liping Zhao, Guanglu Jiang, Hairong Huang National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug Resistant Tuberculosis Research; Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Hairong Huang, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, No. 97 Ma Chang, Tongzhou District, Beijing, 101149, People’s Republic of China, Tel +86-10-89509159, Fax +86-10-89509160, Email huanghairong@tb123.orgBackground: Sudapyridine (WX-081) has exhibited equivalent efficacy than its counterpart parent drug bedaquiline (BDQ) but better safety profile against Mycobacterium tuberculosis (Mtb). Our study was aimed to evaluate in vitro activity of WX-081 against the clinical isolates of Mtb with different drug-resistance profiles and the intracellular bactericidal activity against the reference strain.Methods: The minimum inhibitory concentrations (MICs) of WX-081 and BDQ were tested against 114 Mtb clinical isolates. The intracellular activity of WX-081 and BDQ against the Mtb reference strain H37Rv in THP-1 cells was also evaluated in parallel.Results: The MICs for WX-081 of the enrolled isolates ranged from 0.0156 μg/mL to 1 μg/mL. The MIC50 and MIC90 of WX-081 were, respectively, 0.25 μg/mL and 0.5 μg/mL, with 95.6% of the enrolled strains having MICs ≤ 0.25 μg/mL. For a given strain, the MIC value of WX-081 was generally equivalent to or 2-fold than MIC of BDQ. The intracellular bacterial killing was acquired with the tested drug concentrations that were presumed attainable during clinical usage.Conclusion: WX-081 exhibited potent efficacy against the clinical isolates in vitro. The intracellular killing effect of sudapyridine against the reference strain supports its potential efficacy in treating TB patients.Keywords: tuberculosis, sudapyridine, bedaquiline, antibacterial activity
Published: 2023

28. The Characteristics of Sleep Apnea in Tibetans and Han Long-Term High Altitude Residents

Author: Tan L, Li T, Luo L, Xue X, Lei F, Ren R, Zhang Y, He J, Bloch KE, and Tang X
Subjects: obstructive sleep apnea, high altitude, tibetan, long-term han resident, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Abstract: Lu Tan,1 Taomei Li,1 Lian Luo,1 Xiaofang Xue,2,3 Fei Lei,1 Rong Ren,1 Ye Zhang,1 Jiaming He,2,3 Konrad E Bloch,4 Xiangdong Tang1,5– 7 1Sleep Medicine Center, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Department of Emergency, Diqing Tibetan Autonomous Prefectural People’s Hospital, Shangri-La, People’s Republic of China; 3Department of Intensive Care Unit, Diqing Tibetan Autonomous Prefectural People’s Hospital, Shangri-La, People’s Republic of China; 4Department of Respiratory Medicine, Sleep Disorders Center, University Hospital of Zurich, Zurich, Switzerland; 5Mental Health Center, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 6Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 7State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, People’s Republic of ChinaCorrespondence: Xiangdong Tang, Sleep Medicine Center, Mental Health Center, Department of Respiratory and Critical Care Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 28 Dian Xin Nan Jie, Chengdu, Sichuan, 610041, People’s Republic of China, Tel +86-28-85422733, Fax +86-28-85422632, Email 2372564613@qq.comPurpose: Obstructive sleep apnea (OSA) is common both at low and high altitude. Since adaptations to high altitude and respiratory control may differ among Tibetans and Hans, we compared characteristics of sleep-disordered breathing in the two ethnic groups at high altitude.Materials and Methods: This was a prospective observational study including 86 Tibetan and Han long-term (> 5 years) high altitude residents with chief complaints of snoring and/or witnessed apnea underwent clinical evaluation and polysomnography at 3200 meters in Shangri-La, China.Results: In 42 Tibetans, 38 men, median (quartiles) age was 50.0 (41.0; 56.0)y, total apnea/hypopnea index (AHI) 53.9 (32.0; 77.5)/h, obstructive AHI 51.0 (28.0; 72.2)/h and central AHI 1.5 (0.2; 3.1)/h. In 44 Hans, 32 men, median (quartiles) age was 47.0 (43.5; 51.0)y, total AHI 22.2 (12.8; 39.2)/h, obstructive AHI 17.7 (12.0; 33.0)/h and central AHI 2.4 (0.5; 3.4)/h (p < 0.001 total and obstructive AHI vs Tibetans). In Tibetans, mean nocturnal oxygen saturation was lower [median 85.0 (83.0; 88.0)% vs 88.5 (87.0; 90.0)%] and obstructive apnea and hypopnea duration was longer [22.0 (19.6; 24.8) sec vs 18.3 (16.7; 20.6) sec] than in Hans (all p < 0.001). In regression analysis, Tibetan ethnicity, neck circumference and high-altitude living duration were the predictors of total AHI. We also found that with every 10/h increase in total AHI, there were an approximately 0.9 beat/min and 0.8 beat/min increase in mean heart rate during rapid eye movement (REM) and non-REM sleep and 1.9 mmHg and 2.0 mmHg increase in evening and morning systolic blood pressure.Conclusion: Our data suggest that Tibetans presented more severe obstructive sleep apnea, hypoxemia and longer apnea duration compared to Hans at 3200 meters, which was correlated with higher heart rate and blood pressure suggesting a greater cardiovascular risk.Keywords: obstructive sleep apnea, high altitude, Tibetan, long-term Han resident
Published: 2022

29. Preferences for Patients with Type 2 Diabetes Mellitus for Medications in Shandong Province, China: A Discrete Choice Experiment

Author: Lv Y, Ren R, Tang C, Song K, Li S, and Wang H
Subjects: type 2 diabetes mellitus, patients’ preference, medication, discrete choice experiment, Medicine (General), R5-920
Abstract: Yuyu Lv,1,2 Ru Ren,1– 3 Chengxiang Tang,4 Kuimeng Song,5 Shunping Li,1– 3 Haipeng Wang1,2 1Center for Health Management and Policy Research, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China; 2NHC Key Laboratory of Health Economics and Policy Research (Shandong University), Jinan, People’s Republic of China; 3Center for Health Preference Research, Shandong University, Jinan, People’s Republic of China; 4Macquarie University Centre for the Health Economy, Macquarie University Business School & Australian Institute of Health Innovation, Macquarie University, Sydney, NSW, Australia; 5School of Health Care Security, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, People’s Republic of ChinaCorrespondence: Shunping Li; Haipeng Wang, Centre for Health Management and Policy Research, Wenhua Xi Road 44, Jinan, Shandong Province, 250012, People’s Republic of China, Tel +86-131-8893-4998, +86-186-6899-6362, Email lishunping@sdu.edu.cn; wanghaipeng@sdu.edu.cnPurpose: To evaluate preferences for medications among patients with type 2 diabetes mellitus (T2DM) from urban community health stations or rural village clinics in Shandong province, China.Methods: We use a discrete choice experiment (DCE) to measure the medication preferences. Each patient completed six DCE choice sets. The attributes for the DCE questionnaire include mode of administration, out-of-pocket medication cost per month, fasting blood glucose control effect and frequency of hypoglycemia events. The conditional logit model (Clogit) and mixed logit model (MXL) were used to evaluate choice data.Results: A total of 887 patients with T2DM completed the survey. The mean age of participants was 64 years, 36.42% experienced complications, and the mean duration of diabetes was about 8 years. Overall, patients’ ideal medication would not have hypoglycemia events, provide normal fasting glucose levels, have oral medication three times a day and lower monthly medication cost. Patients prioritized the frequency of hypoglycemia events (β=15.055, P < 0.01) and were willing to spend CNY 393.10 per month to avoid hypoglycemia events. For patients with higher educational levels and with longer diagnosis time, the effect of fasting blood glucose was more relevant than all other outcomes.Conclusion: This study provides information on T2DM patients’ preference for medications. Our results suggest that clinical doctors should present patients with a variety of pharmaceutical characteristics and include their preference into medication decision, which will improve patient adherence and health outcomes.Keywords: type 2 diabetes mellitus, patients’ preference, medication, discrete choice experiment
Published: 2022

30. Correction to: Compression Mechanics for Carbon-Fiber-Reinforced Epoxy Resin Composites under in-Plane and out-of-Plane Quasi-Static and Dynamic Loadings

Author: Zhao, C. F., Ren, R., Sun, C. B., Ren, J., Zhong, J. L., and Zhang, Z. D.
Published: 2023
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31. Search for Low-Mass Dark Matter with CDMSlite Using a Profile Likelihood Fit

Author: SuperCDMS Collaboration, Agnese, R., Aralis, T., Aramaki, T., Arnquist, I. J., Azadbakht, E., Baker, W., Banik, S., Barker, D., Bauer, D. A., Binder, T., Bowles, M. A., Brink, P. L., Bunker, R., Cabrera, B., Calkins, R., Cameron, R. A., Cartaro, C., Cerdeño, D. G., Chang, Y. -Y., Cooley, J., Cornell, B., Cushman, P., De Brienne, F., Doughty, T., Fascione, E., Figueroa-Feliciano, E., Fink, C. W., Fritts, M., Gerbier, G., Germond, R., Ghaith, M., Golwala, S. R., Harris, H. R., Herbert, N., Hong, Z., Hoppe, E. W., Hsu, L., Huber, M. E., Iyer, V., Jardin, D., Jastram, A., Jena, C., Kelsey, M. H., Kennedy, A., Kubik, A., Kurinsky, N. A., Lawrence, R. E., Loer, B., Asamar, E. Lopez, Lukens, P., MacDonell, D., Mahapatra, R., Mandic, V., Mast, N., Miller, E., Mirabolfathi, N., Mohanty, B., Mendoza, J. D. Morales, Nelson, J., Neog, H., Orrell, J. L., Oser, S. M., Page, W. A., Partridge, R., Pepin, M., Ponce, F., Poudel, S., Pyle, M., Qiu, H., Rau, W., Reisetter, A., Ren, R., Reynolds, T., Roberts, A., Robinson, A. E., Rogers, H. E., Saab, T., Sadoulet, B., Sander, J., Scarff, A., Schnee, R. W., Scorza, S., Senapati, K., Serfass, B., Speller, D., Stanford, C., Stein, M., Street, J., Tanaka, H. A., Toback, D., Underwood, R., Villano, A. N., von Krosigk, B., Watkins, S. L., Wilson, J. S., Wilson, M. J., Winchell, J., Wright, D. H., Yellin, S., Young, B. A., Zhang, X., and Zhao, X.
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, Physics - Instrumentation and Detectors
Abstract: The Cryogenic Dark Matter Search low ionization threshold experiment (CDMSlite) searches for interactions between dark matter particles and germanium nuclei in cryogenic detectors. The experiment has achieved a low energy threshold with improved sensitivity to low-mass (<10 GeV/c$^2$) dark matter particles. We present an analysis of the final CDMSlite data set, taken with a different detector than was used for the two previous CDMSlite data sets. This analysis includes a data "salting" method to protect against bias, improved noise discrimination, background modeling, and the use of profile likelihood methods to search for a dark matter signal in the presence of backgrounds. We achieve an energy threshold of 70 eV and significantly improve the sensitivity for dark matter particles with masses between 2.5 and 10 GeV/c$^2$ compared to previous analyses. We set an upper limit on the dark matter-nucleon scattering cross section in germanium of 5.4$\times$10$^{-42}$ cm$^2$ at 5 GeV/c$^2$, a factor of $\sim$2.5 improvement over the previous CDMSlite result.
Published: 2018
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32. Production Rate Measurement of Tritium and Other Cosmogenic Isotopes in Germanium with CDMSlite

Author: SuperCDMS Collaboration, Agnese, R., Aralis, T., Aramaki, T., Arnquist, I. J., Azadbakht, E., Baker, W., Barker, D., Bauer, D. A., Binder, T., Bowles, M. A., Brink, P. L., Bunker, R., Cabrera, B., Calkins, R., Cartaro, C., Cerdeño, D. G., Chang, Y. -Y., Cooley, J., Cornell, B., Cushman, P., Doughty, T., Fascione, E., Figueroa-Feliciano, E., Fink, C. W., Fritts, M., Gerbier, G., Germond, R., Ghaith, M., Golwal, S. R., Harris, H. R., Hong, Z., Hoppe, E. W., Hsu, L., Huber, M. E., Iyer, V., Jardin, D., Jastram, A., Jena, C., Kelsey, M. H., Kennedy, A., Kubik, A., Kurinsky, N. A., Lawrence, R. E., Loer, B., Asamar, E. Lopez, Lukens, P., MacDonell, D., Mahapatra, R., Mandic, V., Mast, N., Miller, E., Mirabolfathi, N., Mohanty, B., Mendoza, J. D. Morales, Nelson, J., Orrell, J. L., Oser, S. M., Page, W. A., Partridge, R., Pepin, M., Ponce, F., Poudel, S., Pyle, M., Qiu, H., Rau, W., Reisetter, A., Ren, R., Reynolds, T., Roberts, A., Robinson, A. E., Rogers, H. E., Saab, T., Sadoulet, B., Banik, S., Sander, J., Scarff, A., Schnee, R. W., Scorza, S., Senapati, K., Serfass, B., Speller, D., Stein, M., Street, J., Tanaka, H. A., Toback, D., Underwood, R., Villano, A. N., von Krosigk, B., Watkins, S. L., Wilson, J. S., Wilson, M. J., Winchell, J., Wright, D. H., Yellin, S., Young, B. A., Zhang, X., and Zhao, X.
Subjects: Physics - Instrumentation and Detectors, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment, Nuclear Experiment
Abstract: Future direct searches for low-mass dark matter particles with germanium detectors, such as SuperCDMS SNOLAB, are expected to be limited by backgrounds from radioactive isotopes activated by cosmogenic radiation inside the germanium. There are limited experimental data available to constrain production rates and a large spread of theoretical predictions. We examine the calculation of expected production rates, and analyze data from the second run of the CDMS low ionization threshold experiment (CDMSlite) to estimate the rates for several isotopes. We model the measured CDMSlite spectrum and fit for contributions from tritium and other isotopes. Using the knowledge of the detector history, these results are converted to cosmogenic production rates at sea level. The production rates in atoms/(kg$\cdot$day) are 74$\pm$9 for $^3$H, 1.5$\pm$0.7 for $^{55}$Fe, 17$\pm$5 for $^{65}$Zn, and 30$\pm$18 for $^{68}$Ge., Comment: 14 pages, 10 figures, 5 tables. v5 contains the extended data release (and documentation) of the CDMSlite Run 2 data as ancillary files
Published: 2018
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33. Search for low-mass dark matter with CDMSlite using a profile likelihood fit

Author: Agnese, R, Aralis, T, Aramaki, T, Arnquist, IJ, Azadbakht, E, Baker, W, Banik, S, Barker, D, Bauer, DA, Binder, T, Bowles, MA, Brink, PL, Bunker, R, Cabrera, B, Calkins, R, Cameron, RA, Cartaro, C, Cerdeño, DG, Chang, Y-Y, Cooley, J, Cornell, B, Cushman, P, De Brienne, F, Doughty, T, Fascione, E, Figueroa-Feliciano, E, Fink, CW, Fritts, M, Gerbier, G, Germond, R, Ghaith, M, Golwala, SR, Harris, HR, Herbert, N, Hong, Z, Hoppe, EW, Hsu, L, Huber, ME, Iyer, V, Jardin, D, Jastram, A, Jena, C, Kelsey, MH, Kennedy, A, Kubik, A, Kurinsky, NA, Lawrence, RE, Loer, B, Asamar, E Lopez, Lukens, P, MacDonell, D, Mahapatra, R, Mandic, V, Mast, N, Miller, E, Mirabolfathi, N, Mohanty, B, Mendoza, JD Morales, Nelson, J, Neog, H, Orrell, JL, Oser, SM, Page, WA, Partridge, R, Pepin, M, Ponce, F, Poudel, S, Pyle, M, Qiu, H, Rau, W, Reisetter, A, Ren, R, Reynolds, T, Roberts, A, Robinson, AE, Rogers, HE, Saab, T, Sadoulet, B, Sander, J, Scarff, A, Schnee, RW, Scorza, S, Senapati, K, Serfass, B, Speller, D, Stanford, C, Stein, M, Street, J, Tanaka, HA, Toback, D, Underwood, R, Villano, AN, von Krosigk, B, Watkins, SL, Wilson, JS, Wilson, MJ, Winchell, J, Wright, DH, Yellin, S, and Young, BA
Subjects: astro-ph.CO, physics.ins-det, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Quantum Physics, Nuclear & Particles Physics
Abstract: The Cryogenic Dark Matter Search low ionization threshold experiment (CDMSlite) searches for interactions between dark matter particles and germanium nuclei in cryogenic detectors. The experiment has achieved a low energy threshold with improved sensitivity to low-mass (
Published: 2019

34. Microstructural, Micromechanical Atlas of the Temporomandibular Joint Disc

Author: Jiang, N., primary, Tan, P., additional, Sun, Y., additional, Zhou, J., additional, Ren, R., additional, Li, Z., additional, and Zhu, S., additional
Published: 2024
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35. Tri-layer ureteral stents offer improved comfort: Results from an international prospective study

Author: Chew, B.H., primary, Forbes, C.M., additional, Wong, K.F.V., additional, Ren, R., additional, Glaser, A., additional, Taguchi, K., additional, Shah, O., additional, Tariel, E., additional, Amarasekera, C., additional, Hamamoto, S., additional, Molina, W.R., additional, Knoedler, J.J., additional, Krambeck, A.E., additional, Rivera, M.E., additional, Stern, K.L., additional, and Humphreys, M.R., additional
Published: 2024
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36. Is shorter better? Associations between pain intensity, ureteral stent indwell time and patient factors from an international prospective registry

Author: Forbes, C.M., primary, Chew, B.H., additional, Wong, K.F.V., additional, Ren, R., additional, Glaser, A., additional, Taguchi, K., additional, Shah, O., additional, Tariel, E., additional, Amarasekera, C., additional, Hamamoto, S., additional, Molina, W.R., additional, Knoedler, J.J., additional, Krambeck, A.E., additional, Humphreys, M.R., additional, and Stern, K.L., additional
Published: 2024
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37. Widespread dissolved inorganic carbon-modifying toolkits in genomes of autotrophic Bacteria and Archaea and how they are likely to bridge supply from the environment to demand by autotrophic pathways

Author: Scott, Kathleen M., primary, Payne, Ren R., additional, and Gahramanova, Arin, additional
Published: 2024
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38. 755-nm Alexandrite Picosecond Laser with a Diffractive Lens Array or Zoom Handpiece for Post-Inflammatory Hyperpigmentation: Two Case Reports with a Three-Year Follow-Up

Author: Ren R, Bao S, Qian W, and Zhao H
Subjects: 755 nm, picosecond laser, long-term effect, post-inflammatory hyperpigmentation, Dermatology, RL1-803
Abstract: Rongxin Ren, Shiwei Bao, Wenjiang Qian, Hongyi Zhao Department of Plastic Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People’s Republic of ChinaCorrespondence: Hongyi ZhaoDepartment of Plastic Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People’s Republic of ChinaTel/Fax +86 10 65238573Email zhaohongyi991@yeah.netObjective: Post-inflammatory hyperpigmentation (PIH) is a reactive hypermelanosis of various skin types, which occurs as a sequela of cutaneous inflammation or injury. Despite generally a self-limited and temporary condition, PIH is still a frustrating problem that can have significant psychosocial effects on patients, especially those with darker skin types. Laser therapy is one of the effective treatments for PIH, and various wavelength lasers and light devices have been utilized in PIH therapy. Nonetheless, data on the long-term efficacy of the 755-nm alexandrite picosecond laser are limited.Methods: This study analyzed two cases of PIH treated with a combination of a 755-nm alexandrite picosecond laser and a diffractive lens array or zoom handpiece. Efficacy of the treatment was determined by the images of skin lesions under a fixed light source before and after each treatment, which were independently reviewed by two plastic-surgery specialists blinded to the clinical data. Improvement was classified as complete (> 75%), significant (50– 75%), mild (25– 50%), and inefficient (< 25% or no obvious change). Skin imaging analysis was carried out using the VISIA system (Canfield, USA), and dermoscopy was performed at the same time.Results: After two to three courses of treatment, all cases showed significant or complete improvement, and no recurrence was observed during the three years of follow-up.Conclusion: A 755-nm alexandrite picosecond laser in combination with a diffractive lens array or zoom handpiece had significant and long-term efficacy for the treatment of PIH caused by trauma. However, attention should be paid to the problem of transient deepening of pigmentation during treatment.Keywords: 755 nm, picosecond laser, long-term effect, post-inflammatory hyperpigmentation
Published: 2021

39. Topical ALA-Photodynamic Therapy Combined with Acne Debridement and Meticulous Nursing for the Treatment of Moderate–Severe Acne in Adolescent Patients

Author: Ren R, Bao S, Qian W, and Zhao H
Subjects: photodynamics, 5-aminolevulinic acid, psychology, pain, meticulous nursing, acne debridement, Dermatology, RL1-803
Abstract: Rongxin Ren, Shiwei Bao, Wenjiang Qian, Hongyi Zhao Department of Plastic Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People’s Republic of ChinaCorrespondence: Hongyi Zhao Email zhaohongyi991@yeah.netObjective: The present study aims to explore the effect of acne debridement + meticulous nursing on 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in adolescent patients with moderate–severe acne.Methods: A total of 60 adolescent patients with moderate–severe acne who were admitted to our plastic surgery outpatient clinic between January 2018 and January 2020 were selected as the subjects of the present retrospective study. The patients were divided into two groups: the observation group and the control group (n = 30, each). Patients in the control group were treated with standardized ALA-PDT and conventional nursing, while patients in the observation group were treated with ALA-PDT and acne debridement + meticulous nursing intervention. The treatment’s therapeutic effect, adverse reaction incidence, and patient satisfaction 6 months after treatment were compared between the two groups.Results: The acne debridement + meticulous nursing effectiveness was 86.7% in the observation group and 60% in the control group, and the adverse reaction incidence was 20% in the observation group and 46.7% in the control group. There existed statistically significant differences in the above-stated indicators between the two groups (p < 0.05). The difference in the visual analogue scores (VASs) for pain, which were measured immediately after the operations, between the two groups was not statistically significant (p > 0.05); however, the respective VAS differences between the two groups at 30 min and 60 min after the operation were statistically significant (p < 0.05). There was a statistically significant difference in patient satisfaction between the two groups (p < 0.05).Conclusion: In adolescent patients with ALA-PDT-treated moderate–severe acne, the application of acne debridement + meticulous nursing could improve the clinical treatment efficacy and patient comfort as well as reduce the adverse reaction incidence. For these reasons, the treatment method could be worth promoting in clinical practice.Keywords: photodynamics, 5-aminolevulinic acid, psychology, pain, meticulous nursing, acne debridement
Published: 2021

40. Metabolomic profile of milk fermented with Streptococcus thermophilus cocultured with Bifidobacterium animalis ssp. lactis, Lactiplantibacillus plantarum, or both during storage

Author: Li, S.N., Tang, S.H., Ren, R., Gong, J.X., and Chen, Y.M.
Published: 2021
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41. The Relationship Between Metabolic Parameters, Age, and Thyroid Status: A Cross-Sectional Study-Based National Survey of Iodine Nutrition, Thyroid Disease

Author: Deng B, Yuan Y, Zhong M, Ren R, Deng W, and Duan X
Subjects: thyroid function, metabolic status, aging, Public aspects of medicine, RA1-1270
Abstract: Bo Deng,1,* Yi Yuan,1,* Miao Zhong,1,* Rui Ren,1 Wuquan Deng,1 Xiaodong Duan2 1Department of Endocrinology, Chongqing University Central Hospital, Chongqing Emergency Medical Center, Chongqing, 400014, People’s Republic of China; 2Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaodong Duan Email duanxiaodong2032@sina.comAim: The relationship between thyroid status and metabolic factors was investigated as well as iodine nutrition in the general population and among the elderly population.Methods: We performed a cross-sectional survey of 2483 subjects to assess the status of national iodine nutrition and incidence of thyroid disease. The general and elderly populations were divided into normal thyroid function (NTF) and subclinical hypothyroidism (SCH) groups. The anthropometric parameters and biochemical indicators were then analyzed.Results: Overall, 327 participants were diagnosed with thyroid diseases, 73 (22.32%) of whom were 65 years or older. For the general population, compared with the NTF group, individuals in the SCH group were older, presented with higher systolic blood pressure, fasting blood glucose, serum cholesterol, and urinary iodine concentration (all p< 0.05) but lower blood uric acid (UA) (p< 0.05). Linear regression analysis further revealed that age and triglyceride (TG) serum levels positively correlated with serum thyroid-stimulating hormone (TSH) levels. Multiple regression analyses revealed that age, TG, waist circumference (WC), and body mass index were independent predictors for abnormal TSH serum levels. For the elderly population, compared with NTF group, individuals in the SCH group were substantially older (p< 0.05) but presented with lower UA (p< 0.05). Pearson linear regression analysis revealed a positive correlation between age (p=0.003) as well as TG levels (p< 0.001) and serum TSH levels. In contrast, WC (p=0.003) was negatively related to TSH serum levels. Further multiple regression analysis revealed that age, TG, WC and heart rate were independent predictors of blood TSH.Conclusion: The large-scale national study of iodine nutrition, thyroid disease has shown a vital relationship between metabolic indicators and serum TSH levels. Age and metabolic diseases increase the likelihood of developing thyroid diseases, both the general population and among the elderly.Keywords: thyroid function, metabolic status, aging
Published: 2021

42. Evaluating the sensitivity of EQ-5D-5L in patients with brain metastases: a secondary analysis of NRG CC001.

Author: Cherng, Hua-Ren R, Qu, Melody, Zafari, Zafar, Bentzen, Søren M, Armstrong, Terri S, Gondi, Vinai, Brown, Paul D, Mehta, Minesh, and Mishra, Mark V
Subjects: *SECONDARY analysis, *QUALITY of life, *VISUAL analog scale, *BRAIN tumors
Abstract: Background EuroQoL EQ-5D-5L is a commonly used measure of health-related quality of life in clinical trials given the use of its index score as a measure of health utilities. It is unclear whether EQ-5D-5L is sensitive to changes in neurocognitive function and progression that occur following brain radiation. This study sought to evaluate the sensitivity of EQ-5D-5L in reflecting these changes. Methods A secondary analysis of NRG Oncology CC001 was performed. Mean EQ-5D-5L index and visual analog scale (VAS) score changes from baseline between groups of patients stratified by neurocognitive function and intracranial progression status were assessed. MD Anderson Symptom Inventory for brain tumor (MDASI-BT) symptom and interference items were also analyzed between groups. Results EQ-5D-5L mean index and VAS score changes between patients who had cognitive failure and those who had preserved cognition showed no statistically significant differences at any timepoint. In contrast, VAS changes at 4 months (1.61 vs -5.13, P = .05) and 6 months (8.17 vs −0.14, P = .04) were significantly improved in the patients who survived without intracranial progression. MDASI-BT cognitive factor scores were improved in the cohort of patients with preserved neurocognitive function at 2 months (1.68 vs 2.08, P = .05) and 4 months (1.35 vs 1.83, P = .04). MDASI-BT symptom interference was significantly associated with intracranial progression at 4 months, but not with neurocognitive status. Conclusion EQ-5D-5L index and VAS scores were not sensitive to neurocognitive changes that patients experienced, but VAS scores were sensitive to progression. This study challenges the routine use of EQ-5D as a quality of life metric in brain metastases clinical trials that are focused on preventing neurocognitive dysfunction. Trial Registration NCT# 02360215. [ABSTRACT FROM AUTHOR]
Published: 2024
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43. Evaluating the heterogeneity of hippocampal avoidant whole brain radiotherapy treatment effect: A secondary analysis of NRG CC001.

Author: Cherng, Hua-Ren R, Sun, Kai, Bentzen, Søren, Armstrong, Terri S, Gondi, Vinai, Brown, Paul D, Mehta, Minesh, and Mishra, Mark V
Published: 2024
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44. Evaluating the Heterogeneity of Hippocampal Avoidant Whole Brain Radiotherapy Treatment Effect: A Secondary Analysis of NRG CC001

Author: Cherng, Hua-Ren R, primary, Sun, Kai, additional, Bentzen, Soren, additional, Armstrong, Terri S, additional, Gondi, Vinai, additional, Brown, Paul D, additional, Mehta, Minesh, additional, and Mishra, Mark V, additional
Published: 2023
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45. CircRNA Circ_0001721 Promotes the Progression of Osteosarcoma Through miR-372-3p/MAPK7 Axis

Author: Gao Y, Ma H, Tao K, Fu L, Ren R, Hu X, Kou M, Chen B, Shi J, and Wen Y
Subjects: circ_0001721, mir-372-3p, mapk7, osteosarcoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Yuanpeng Gao,1,* Haixia Ma,2,* Yan Gao,3 Kai Tao,4 Liyan Fu,5 Ruimin Ren,6 Xingui Hu,7 Min Kou,8 Bin Chen,1 Junjun Shi,1 Yunpeng Wen9 1Department of Orthopaedics,The Second Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 2Department of Pathology, Tumor Hospital of Shanxi, Taiyuan, People’s Republic of China; 3Department of VitreoretinalSurgery, Shanxi Eye Hospital, Taiyuan, People’s Republic of China; 4Department of Digestive Minimally Invasive Surgery, Tumor Hospital of Shanxi, Taiyuan, People’s Republic of China; 5Comprehensive Examination Department, Children’s Hospital of Shanxi Province, Taiyuan, People’s Republic of China; 6Department of Urology Surgery, Shanxi Bethune Hospital, Taiyuan, People’s Republic of China; 7Department of Cardiology, Taiyuan Iron and Steel Group General Hospital, Taiyuan, People’s Republic of China; 8Department of Nephrology, Children’s Hospital of Shanxi Province, Taiyuan, People’s Republic of China; 9Department of Rehabilitation, Shanxi Huajin Orthopedic Hospital, Taiyuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Junjun Shi Tel/fax +86 0351 6125623Email gypfly147852@163.comYunpeng Wen Tel/fax +86 0351 6185361Email nmepvb@163.comBackground: Osteosarcoma (OS) is the most common bone tumor. Many studies have reported that circular RNAs (circRNAs) play an important role in the development of a variety of human cancers. However, the underlying mechanism of circ_0001721 in regulating osteosarcoma progression remains unknown.Materials and Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the levels of circ_0001721, miR-372-3p, and mitogen-activated protein kinase 7 (MAPK7) in osteosarcoma tissues and cells. Besides, glycolysis was investigated by glucose consumption, lactate production and hexokinase II (HK2) protein level. Cell proliferation and apoptosis were determined by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) and flow cytometry, separately. Cell migration and invasion were determined by transwell assay. Moreover, the protein levels of HK2 and epithelial-to-mesenchymal transition (EMT) markers were determined by Western blot analysis. The relationship between miR-372-3p and circ_0001721 or MAPK7 was predicated by starbase v3.0 and confirmed by dual-luciferase reporter assay or RNA binding protein immunoprecipitation (RIP) assay. Murine xenograft model was established to investigate the role of circ_0001721 in vivo.Results: The levels of circ_0001721 and MAPK7 were upregulated in osteosarcoma tissues and cells, while miR-372-3p was downregulated. Knockdown of circ_0001721 inhibited glycolysis, cell proliferation, cell migration, invasion and epithelial-to-mesenchymal transition (EMT), and promoted apoptosis. Circ_0001721 was validated as a sponge of miR-372-3p and mediated glycolysis, cell proliferation, apoptosis, migration, invasion, and EMT of osteosarcoma cells through miR-372-3p. MAPK7 was a target of miR-372-3p and overexpression of MAPK7 attenuated anti-cancer role of miR-372-3p in OS cells. Further studies revealed that circ_0001721 regulates MAPK7 expression via sponging miR-372-3-p. Finally, knockdown of circ_0001721 inhibited tumor progression in vivo.Conclusion: Circ_0001721 promoted osteosarcoma development through the miR-372-3p/MAPK7 axis.Keywords: circ_0001721, miR-372-3p, MAPK7, osteosarcoma
Published: 2020

46. A multi-center analysis of single-fraction versus hypofractionated stereotactic radiosurgery for the treatment of brain metastasis

Author: Jill S. Remick, Emily Kowalski, Rahul Khairnar, Kai Sun, Emily Morse, Hua-Ren R. Cherng, Yannick Poirier, Narottam Lamichhane, Stewart J. Becker, Shifeng Chen, Akshar N. Patel, Young Kwok, Elizabeth Nichols, Pranshu Mohindra, Graeme F. Woodworth, William F. Regine, and Mark V. Mishra
Subjects: Brain metastasis, Stereotactic radiosurgery, Hypofractionated stereotactic radiosurgery, GammaKnife, Normal tissue injury, Biologic effective dose, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Abstract Background Hypofractionated-SRS (HF-SRS) may allow for improved local control and a reduced risk of radiation necrosis compared to single-fraction-SRS (SF-SRS). However, data comparing these two treatment approaches are limited. The purpose of this study was to compare clinical outcomes between SF-SRS versus HF-SRS across our multi-center academic network. Methods Patients treated with SF-SRS or HF-SRS for brain metastasis from 2013 to 2018 across 5 radiation oncology centers were retrospectively reviewed. SF-SRS dosing was standardized, whereas HF-SRS dosing regimens were variable. The co-primary endpoints of local control and radiation necrosis were estimated using the Kaplan Meier method. Multivariate analysis using Cox proportional hazards modeling was performed to evaluate the impact of select independent variables on the outcomes of interest. Propensity score adjustments were used to reduce the effects confounding variables. To assess dose response for HF-SRS, Biologic Effective Dose (BED) assuming an α/β of 10 (BED10) was used as a surrogate for total dose. Results One-hundred and fifty six patients with 335 brain metastasis treated with SF-SRS (n = 222 lesions) or HF-SRS (n = 113 lesions) were included. Prior whole brain radiation was given in 33% (n = 74) and 34% (n = 38) of lesions treated with SF-SRS and HF-SRS, respectively (p = 0.30). After a median follow up time of 12 months in each cohort, the adjusted 1-year rate of local control and incidence of radiation necrosis was 91% (95% CI 86–96%) and 85% (95% CI 75–95%) (p = 0.26) and 10% (95% CI 5–15%) and 7% (95% CI 0.1–14%) (p = 0.73) for SF-SRS and HF-SRS, respectively. For lesions > 2 cm, the adjusted 1 year local control was 97% (95% CI 84–100%) for SF-SRS and 64% (95% CI 43–85%) for HF-SRS (p = 0.06). On multivariate analysis, SRS fractionation was not associated with local control and only size ≤2 cm was associated with a decreased risk of developing radiation necrosis (HR 0.21; 95% CI 0.07–0.58, p
Published: 2020
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47. Improved Immunoregulation of Ultra-Low-Dose Silver Nanoparticle-Loaded TiO2 Nanotubes via M2 Macrophage Polarization by Regulating GLUT1 and Autophagy

Author: Chen Y, Guan M, Ren R, Gao C, Cheng H, Li Y, Gao B, Wei Y, Fu J, Sun J, and Xiong W
Subjects: silver nanoparticle, tio2 nanotubes, immune response, glucose transport, autophagy, Medicine (General), R5-920
Abstract: Yangmengfan Chen,1,* Ming Guan,1,* Ranyue Ren,1 Chenghao Gao,1 Hao Cheng,2 Yong Li,1 Biao Gao,3 Yong Wei,3 Jijiang Fu,3 Jun Sun,4 Wei Xiong1 1Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China; 2Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, People’s Republic of China; 3The State Key Laboratory of Refractories and Metallurgy, School of Materials and Metallurgy, Wuhan University of Science and Technology, Wuhan 430081, People’s Republic of China; 4Department of Biochemistry and Molecular Biology, Basic Medical School, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jun SunDepartment of Biochemistry and Molecular Biology, Basic Medical School, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of ChinaTel +86 189 7128 0215Email sunjun99@hotmail.comWei XiongDepartment of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, People’s Republic of ChinaTel +86 132 1273 6006Email 1996tj0558@hust.edu.cnIntroduction: The bone regeneration of endosseous implanted biomaterials is often impaired by the host immune response, especially macrophage-related inflammation which plays an important role in the bone healing process. Thus, it is a promising strategy to design an osteo-immunomodulatory biomaterial to take advantage of the macrophage-related immune response and improve the osseointegration performance of the implant.Methods: In this study, we developed an antibacterial silver nanoparticle-loaded TiO2 nanotubes (Ag@TiO2-NTs) using an electrochemical anodization method to make the surface modification and investigated the influences of Ag@TiO2-NTs on the macrophage polarization, osteo-immune microenvironment as well as its potential molecular mechanisms in vitro and in vivo.Results: The results showed that Ag@TiO2-NTs with controlled releasing of ultra-low-dose Ag+ ions had the excellent ability to induce the macrophage polarization towards the M2 phenotype and create a suitable osteo-immune microenvironment in vitro, via inhibiting PI3K/Akt, suppressing the downstream effector GLUT1, and activating autophagy. Moreover, Ag@TiO2-NTs surface could improve bone formation, suppress inflammation, and promote osteo-immune microenvironment compared to the TiO2-NTs and polished Ti surfaces in vivo. These findings suggested that Ag@TiO2-NTs with controlled releasing of ultra-low-dose Ag+ ions could not only inhibit the inflammation process but also promote the bone healing by inducing healing-associated M2 polarization.Discussion: Using this surface modification strategy to modulate the macrophage-related immune response, rather than prevent the host response, maybe a promising strategy for implant surgeries in the future.Keywords: silver nanoparticle, TiO2 nanotubes, immune response, glucose transport, autophagy
Published: 2020

48. Production rate measurement of Tritium and other cosmogenic isotopes in Germanium with CDMSlite

Author: Agnese, R., Aralis, T., Aramaki, T., Arnquist, I.J., Azadbakht, E., Baker, W., Banik, S., Barker, D., Bauer, D.A., Binder, T., Bowles, M.A., Brink, P.L., Bunker, R., Cabrera, B., Calkins, R., Cartaro, C., Cerdeño, D.G., Chang, Y.-Y., Cooley, J., Cornell, B., Cushman, P., Doughty, T., Fascione, E., Figueroa-Feliciano, E., Fink, C.W., Fritts, M., Gerbier, G., Germond, R., Ghaith, M., Golwala, S.R., Harris, H.R., Hong, Z., Hoppe, E.W., Hsu, L., Huber, M.E., Iyer, V., Jardin, D., Jastram, A., Jena, C., Kelsey, M.H., Kennedy, A., Kubik, A., Kurinsky, N.A., Lawrence, R.E., Loer, B., Lopez Asamar, E., Lukens, P., MacDonell, D., Mahapatra, R., Mandic, V., Mast, N., Miller, E., Mirabolfathi, N., Mohanty, B., Morales Mendoza, J.D., Nelson, J., Orrell, J.L., Oser, S.M., Page, W.A., Partridge, R., Pepin, M., Ponce, F., Poudel, S., Pyle, M., Qiu, H., Rau, W., Reisetter, A., Ren, R., Reynolds, T., Roberts, A., Robinson, A.E., Rogers, H.E., Saab, T., Sadoulet, B., Sander, J., Scarff, A., Schnee, R.W., Scorza, S., Senapati, K., Serfass, B., Speller, D., Stein, M., Street, J., Tanaka, H.A., Toback, D., Underwood, R., Villano, A.N., von Krosigk, B., Watkins, S.L., Wilson, J.S., Wilson, M.J., Winchell, J., Wright, D.H., Yellin, S., Young, B.A., Zhang, X., and Zhao, X.
Published: 2019
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49. A Consistent Model of `Explosive' Financial Bubbles With Mean-Reversing Residuals

Author: Lin, L., E, Ren R., and Sornette, D.
Subjects: Quantitative Finance - Risk Management, Quantitative Finance - General Finance
Abstract: We present a self-consistent model for explosive financial bubbles, which combines a mean-reverting volatility process and a stochastic conditional return which reflects nonlinear positive feedbacks and continuous updates of the investors' beliefs and sentiments. The conditional expected returns exhibit faster-than-exponential acceleration decorated by accelerating oscillations, called "log-periodic power law." Tests on residuals show a remarkable low rate (0.2%) of false positives when applied to a GARCH benchmark. When tested on the S&P500 US index from Jan. 3, 1950 to Nov. 21, 2008, the model correctly identifies the bubbles ending in Oct. 1987, in Oct. 1997, in Aug. 1998 and the ITC bubble ending on the first quarter of 2000. Different unit-root tests confirm the high relevance of the model specification. Our model also provides a diagnostic for the duration of bubbles: applied to the period before Oct. 1987 crash, there is clear evidence that the bubble started at least 4 years earlier. We confirm the validity and universality of the volatility-confined LPPL model on seven other major bubbles that have occurred in the World in the last two decades. Using Bayesian inference, we find a very strong statistical preference for our model compared with a standard benchmark, in contradiction with Chang and Feigenbaum (2006) which used a unit-root model for residuals., Comment: 32 pages with 2 figures and 7 tables
Published: 2009

50. Association between serum TSH levels and metabolic components in euthyroid subjects: a nationwide population-based study

Author: Ren R, Ma Y, Deng F, Li T, Wang H, Wei J, Jiang X, He M, Tian M, Liu D, Chen B, and Deng W
Subjects: thyroid-stimulating hormone, metabolic syndrome, iodine nutrition, euthyroid state, Specialties of internal medicine, RC581-951
Abstract: Rui Ren,1,2 Yu Ma,2 Fang Deng,1 Tao Li,1 Hongyan Wang,2 Jing Wei,3 Xiaoyan Jiang,2 Min He,1 Mingyuan Tian,4 Dongfang Liu,4 Bing Chen,1 Wuquan Deng1,21Department of Endocrinology and Nephrology, Chongqing University Central Hospital, Chongqing Emergency Medical Center, Chongqing, People’s Republic of China; 2Department of Endocrinology, Southwest Hospital, Army Medical University, Chongqing, People’s Republic of China; 3Department of Endocrinology, General Hospital of Xinjiang Military Region, PLA, Urumqi, People’s Republic of China; 4Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Wuquan DengDepartment of Endocrinology and Nephrology, Chongqing University Central Hospital, Chongqing Emergency Medical Center, No. 1 Jiankang Road, Yuzhong District, Chongqing, People’s Republic of ChinaTel +86 236 369 2185Email wuquandeng@gmail.comBackground: Whether a relationship exists between various metabolic factors and thyroid-stimulating hormone (TSH) levels in euthyroid persons remains unknown. This study aims to explore the relationship between TSH levels and metabolic factors in euthyroid individuals.Methods: A total of 2,663 subjects were enrolled from a nationwide population-based cross-sectional survey of iodine nutrition, thyroid disease and diabetes in China (2014–2017). Euthyroid individuals were divided into four groups according to quartiles of TSH levels: group A (n=305, 0.3–1.3 mIU/L), group B (n=829, 1.3–2.2 mIU/L), group C (n=673, 2.2–3.2 mIU/L) and group D (n=349, 3.2–4.2 mIU/L). Anthropometric parameters, biochemical indicators and TSH levels were determined.Results: A total of 2,156 euthyroid subjects with serum TSH levels within the normal range accounted for 86.8% of the sample. The systolic blood pressure (SBP) in group D was significantly higher than that in the other three groups. Group C displayed significantly lower thyroid peroxidase antibody (TPOAb) levels than the other three groups. Group C also had lower anti-thyroglobulin antibody (TgAb) levels than groups A and D, whereas the TgAb levels in group B were only lower than those in group A. Spearman’s or Pearson’s linear regression analysis showed that SBP (r=0.054; P=0.013) was positively correlated with TSH, but cholesterol (TC) (r=−0.043, P=0.047) was negatively correlated with TSH. Multiple stepwise regression analysis revealed that SBP, the urinary iodine concentration (UIC), waist circumference (WC), body mass index (BMI), TC, triglycerides (TGs) and low-density lipoprotein cholesterol (LDL-C) were independent predictors of serum TSH levels.Conclusion: This large population-based study demonstrates a significant interaction between metabolic factors and TSH levels. An adverse weight status, high blood pressure levels, blood lipid metabolism disorder and excessive iodine intake may be early manifestations of thyroid disease in euthyroid subjects.Keywords: thyroid-stimulating hormone, metabolic syndrome, iodine nutrition, euthyroid state
Published: 2019

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