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In the process of informationization and networking of smart grids, the original physical isolation was broken, potential risks increased, and the increasingly serious cyber security situation was faced. Therefore, it is critical to develop accuracy and efficient anomaly detection methods to disclose various threats. However, in the industry, mainstream security devices such as firewalls are not able to detect and resist some advanced behavior attacks. In this paper, we propose a time series anomaly detection model, which is based on the periodic extraction method of discrete Fourier transform, and determines the sequence position of each element in the period by periodic overlapping mapping, thereby accurately describe the timing relationship between each network message. The experiments demonstrate that our model can detect cyber attacks such as man-in-the-middle, malicious injection, and Dos in a highly periodic network.

As an important part of the national infrastructure, the power grid is facing more and more network security threats in the process of turning from traditional relative closure to informationization and networking. Therefore, it is necessary to develop effective anomaly detection methods to resist various threats. However, the current methods mostly use each packet in the network as the detection object, ignore the overall timing pattern of the network, cannot detect some advanced behavior attacks. In this paper, we introduce the concept of network flow, which consists of the same end-to-end network packets, besides the network flow fragmentation divides the network flow into pieces at regular intervals. We also propose a network flow anomaly detection method based on density clustering, which uses bidirectional flow statistics as features. The experimental result demonstrate that the methodology has excellent detection effect on large-scale malicious traffic and injection attacks.

Antimicrobial resistance is one of the most complex global health challenges today. The world has long ignored warnings that some antibiotics are losing effectiveness after decades of overuse and misuse in human medicine, animal health and agriculture. Antivirals, antiparasitic agents and antifungals are also becoming increasingly ineffective. Though we live in an age of technology and innovation, we could soon find ourselves in an era where simple infections kill millions of people every year. Common illnesses like bacterial pneumonia, post-operative infections, certain cancers, as well as the world's biggest infectious killers--tuberculosis, human immunodeficiency virus (HIV) and malaria--are increasingly difficult to treat because of the emergence and spread of drug resistance. (1) Worsening antimicrobial resistance could have serious public health, economic and social implications around the world. The World Bank has warned that antimicrobial resistance could cause as much damage to the global economy as the 2008 financial crisis. (2) Antimicrobial resistance can only be tackled through a concerted global effort, led by heads of state and global institutions, and through coordinated action by the health and agricultural sectors, in partnership with the food industry, campaign groups and community organizations. Governments need closely aligned policies on the responsible use of medicines in human and animal health, and new standards for antibiotic use in agriculture and food production. A one health approach, involving close coordination among all relevant sectors and actors, should be urgently implemented by all governments. In the past two years, we have seen global political momentum for addressing antimicrobial resistance. In May 2015, at the Sixty-eighth World Health Assembly, governments adopted a global action plan which identifies a set of strategic objectives. (1,3) In 2016, the United Nations General Assembly held the first high-level meeting on antimicrobial resistance and passed a political declaration. (4) The issue has also been on the agenda of recent group of seven (G7) and group of twenty (G20) meetings. Since May 2015, progress has also been made in the implementation of these global commitments. Over one hundred countries have completed, or are about to complete, their national multisectoral action plans. WHO has established a global antimicrobial resistance surveillance system to track which drug-resistant pathogens are posing the biggest challenge. (5) In May 2016, the Drugs for Neglected Diseases initiative and WHO launched a global research and development partnership to develop new antibiotics and promote their responsible use. (6) In August 2016, WHO updated its guidelines for the prevention and treatment of the three common sexually transmitted infections--chlamydia, gonorrhoea and syphilis. …

Anti-microbial resistance, emerging infectious diseases, and neglected diseases are all important public health concerns and priorities with serious market failures, deficits, and identified needs in biomedical innovation. It is important to reconcile, rather than fragment, the needs of these three priority areas by considering an umbrella framework for specifically financing and coordinating research and development (R&D) that delivers innovation while securing patient access. A sizeable, sustainably financed global R&D fund and mechanism that promotes coordination, collaboration, and utilization of new and innovative incentives should be set up to cover all three priority areas.