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11 results on '"Ren, Casey"'

3. Expression of microRNAs and their target genes in melanomas originating from gynecologic sites

Author

DiVincenzo, Mallory J., primary, Angell, Colin D., additional, Suarez-Kelly, Lorena P., additional, Ren, Casey, additional, Barricklow, Zoe, additional, Moufawad, Maribelle, additional, Fadda, Paolo, additional, Yu, Lianbo, additional, Backes, Floor J., additional, Ring, Kari, additional, Mills, Anne, additional, Slingluff, Craig, additional, Chung, Catherine, additional, Gru, Alejandro A., additional, and Carson, William E., additional

Published
2023
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5. Abstract 3764: Expression patterns of microRNAs and associated target genes in ulcerated primary cutaneous melanoma

Author

Schwarz, Emily, primary, DiVincenzo, Mallory J., additional, Ren, Casey, additional, Barricklow, Zoe, additional, Moufawad, Maribelle, additional, Yu, Lianbo, additional, Fadda, Paolo, additional, Angell, Colin, additional, Zelinskas, Sara, additional, Sun, Steven, additional, Howard, John H., additional, Chung, Catherine, additional, Slingluff, Craig, additional, Gru, Alejandro A., additional, Kendra, Kari, additional, and Carson, William E., additional

Published
2023
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6. Expression Patterns of microRNAs and Associated Target Genes in Ulcerated Primary Cutaneous Melanoma

Author

DiVincenzo, Mallory J., primary, Schwarz, Emily, additional, Ren, Casey, additional, Barricklow, Zoe, additional, Moufawad, Maribelle, additional, Yu, Lianbo, additional, Fadda, Paolo, additional, Angell, Colin, additional, Sun, Steven, additional, Howard, J. Harrison, additional, Chung, Catherine, additional, Slingluff, Craig, additional, Gru, Alejandro A., additional, Kendra, Kari, additional, and Carson, William E., additional

Published
2022
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7. Antibody Conjugation of Fluorescent Nanodiamonds for Targeted Innate Immune Cell Activation

Author

Suarez-Kelly, Lorena P., primary, Sun, Steven H., additional, Ren, Casey, additional, Rampersaud, Isaac V., additional, Albertson, David, additional, Duggan, Megan C., additional, Noel, Tiffany C., additional, Courtney, Nicholas, additional, Buteyn, Nathaniel J., additional, Moritz, Charles, additional, Yu, Lianbo, additional, Yildiz, Vedat O., additional, Butchar, Jonathan P., additional, Tridandapani, Susheela, additional, Rampersaud, Arfaan A., additional, and Carson, William E., additional

Published
2021
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11. Targeting Myeloid-Derived Suppressor Cells via Dual-Antibody Fluorescent Nanodiamond Conjugate.

Author

Angell CD, Lapurga G, Sun SH, Johnson C, Savardekar H, Rampersaud IV, Fletcher C, Albertson D, Ren C, Suarez-Kelly LP, Rampersaud AA, and Carson WE 3rd

Abstract

Fluorescent nanodiamonds (FNDs) are carbon-based nanomaterials that emit bright, photostable fluorescence and exhibit a modifiable surface chemistry. Myeloid-derived suppressor cells (MDSCs) are an immunosuppressive cell population known to expand in cancer patients and contribute to worse patient outcomes. To target MDSC, glycidol-coated FND were conjugated with antibodies against the murine MDSC markers, CD11b and GR1 (dual-Ab FND). In vitro, dual-Ab FND uptake by murine MDSC was significantly higher than IgG-coated FND (94.7% vs. 69.0%, p < 0.05). In vivo, intra-tumorally injected dual-Ab FND primarily localized to the tumor 2 and 24 h post-injection, as measured by in vivo fluorescence imaging and flow cytometry analysis of the spleen and tumor. Dual-Ab FND were preferentially taken up by intra-tumoral MDSC, representing 87.1% and 83.0% of FND+ cells in the tumor 2 and 24 h post-injection, respectively. Treatment of mice with anti-PD-L1 immunotherapy prior to intra-tumoral injection of dual-Ab FND did not significantly alter the uptake of FND by MDSC. These results demonstrate the ability of our novel dual-antibody conjugated FND to target MDSC and reveal a potential strategy for targeted delivery to other specific immune cell populations in future cancer research.

Published
2024
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