18 results on '"Relimpio-López, María Isabel"'
Search Results
2. Polarimetric imaging for the detection of synthetic models of SARS-CoV-2: a proof of concept
- Author
-
Gomez-Gonzalez, Emilio, Muñoz, Olga, Gomez-Martin, Juan Carlos, Aceituno-Castro, Jesus, Fernandez-Muñoz, Beatriz, Navas-Garcia, Jose Manuel, Barriga-Rivera, Alejandro, Fernandez-Lizaranzu, Isabel, Munoz-Gonzalez, Francisco Javier, Parrilla-Giraldez, Ruben, Requena-Lancharro, Desiree, Gil-Gamboa, Pedro, Ramos, José Luis, Rosell-Valle, Cristina, Gomez-Gonzalez, Carmen, Martin-Lopez, Maria, Relimpio-Lopez, Maria Isabel, Perales-Esteve, Manuel A., Puppo-Moreno, Antonio, Garcia-Cozar, Francisco Jose, Olvera-Collantes, Lucia, Santos-Trigo, Silvia de los, Gomez, Emilia, Sanchez-Pernaute, Rosario, Padillo-Ruiz, Javier, and Marquez-Rivas, Javier
- Subjects
Physics - Medical Physics ,Physics - Optics - Abstract
Objective: To conduct a proof-of-concept study of the detection of two synthetic models of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using polarimetric imaging. Methods: Two SARS-CoV-2 models were prepared as engineered lentiviruses pseudotyped with the G protein of the vesicular stomatitis virus, and with the characteristic Spike protein of SARS-CoV-2. Samples were preparations in two biofluids (saline solution and artificial saliva), in four concentrations, and deposited as 5-{\mu}L droplets on a supporting plate. The angles of maximal degree of linear polarization (DLP) of light diffusely scattered from dry residues were determined using Mueller polarimetry of 87 samples at 405 nm and 514 nm. A polarimetric camera was used for simultaneous imaging of several samples under 380-420 nm illumination at angles similar to those of maximal DLP. A per-pixel image analysis included quantification and combination of polarization feature descriptors in other 475 samples. Results: The angles (from sample surface) of maximal DLP were 3 degrees for 405 nm and 6 degrees for 514 nm. Similar viral particles that differ only in the characteristic spike protein of the SARS-CoV-2, their corresponding negative controls, fluids, and the sample holder were discerned from polarimetric image analysis at 10-degree and 15-degree configurations. Conclusion: Polarimetric imaging in the visible spectrum has the potential for non-contact, reagent-free detection of viruses in multiple dry fluid residues simultaneously. Further analysis including real SARS-CoV-2 in human samples -- particularly, fresh saliva -- are required. Significance: Polarimetric imaging under visible light could contribute to fast, cost-effective screening of SARS-CoV-2 and other pathogens.
- Published
- 2022
- Full Text
- View/download PDF
3. Artificial intelligence in medicine and healthcare: a review and classification of current and near-future applications and their ethical and social Impact
- Author
-
Gómez-González, Emilio, Gomez, Emilia, Márquez-Rivas, Javier, Guerrero-Claro, Manuel, Fernández-Lizaranzu, Isabel, Relimpio-López, María Isabel, Dorado, Manuel E., Mayorga-Buiza, María José, Izquierdo-Ayuso, Guillermo, and Capitán-Morales, Luis
- Subjects
Computer Science - Computers and Society ,Computer Science - Artificial Intelligence - Abstract
This paper provides an overview of the current and near-future applications of Artificial Intelligence (AI) in Medicine and Health Care and presents a classification according to their ethical and societal aspects, potential benefits and pitfalls, and issues that can be considered controversial and are not deeply discussed in the literature. This work is based on an analysis of the state of the art of research and technology, including existing software, personal monitoring devices, genetic tests and editing tools, personalized digital models, online platforms, augmented reality devices, and surgical and companion robotics. Motivated by our review, we present and describe the notion of 'extended personalized medicine', we then review existing applications of AI in medicine and healthcare and explore the public perception of medical AI systems, and how they show, simultaneously, extraordinary opportunities and drawbacks that even question fundamental medical concepts. Many of these topics coincide with urgent priorities recently defined by the World Health Organization for the coming decade. In addition, we study the transformations of the roles of doctors and patients in an age of ubiquitous information, identify the risk of a division of Medicine into 'fake-based', 'patient-generated', and 'scientifically tailored', and draw the attention of some aspects that need further thorough analysis and public debate.
- Published
- 2020
4. Polarimetric imaging for the detection of synthetic models of SARS-CoV-2: A proof of concept
- Author
-
Gomez-Gonzalez, Emilio, Muñoz, Olga, Gomez-Martin, Juan Carlos, Aceituno-Castro, Jesus, Fernandez-Muñoz, Beatriz, Navas-Garcia, Jose Manuel, Barriga-Rivera, Alejandro, Fernandez-Lizaranzu, Isabel, Munoz-Gonzalez, Francisco Javier, Parrilla-Giraldez, Ruben, Requena-Lancharro, Desiree, Gil-Gamboa, Pedro, Ramos, José Luis, Rosell-Valle, Cristina, Gomez-Gonzalez, Carmen, Martin-Lopez, Maria, Relimpio-Lopez, Maria Isabel, Perales-Esteve, Manuel A., Puppo-Moreno, Antonio, Garcia-Cozar, Francisco Jose, Olvera-Collantes, Lucia, de los Santos-Trigo, Silvia, Gomez, Emilia, Sanchez-Pernaute, Rosario, Padillo-Ruiz, Javier, and Marquez-Rivas, Javier
- Published
- 2023
- Full Text
- View/download PDF
5. Long-Term Mental Health after High-Density Polyethylene-Based Porous Orbital Implant in Enucleated and Eviscerated Patients.
- Author
-
Garrido-Hermosilla, Antonio Manuel, Martínez-Alberquilla, Irene, Díaz-Ruiz, María Concepción, Monge-Carmona, Raquel, Méndez-Muros, Mariola, López-Díaz, Álvaro, Sánchez-Margalet, Víctor, Gutiérrez-Sánchez, Estanislao, Relimpio-López, María Isabel, and Rodríguez-de-la-Rúa-Franch, Enrique
- Subjects
COMPETENCY assessment (Law) ,PROSTHETICS ,RESEARCH funding ,SURGERY ,PATIENTS ,QUESTIONNAIRES ,ARTIFICIAL implants ,DESCRIPTIVE statistics ,CHI-squared test ,ANXIETY ,LONGITUDINAL method ,ANHEDONIA ,ENUCLEATION of the eye ,ANALYSIS of variance ,QUALITY of life ,OPHTHALMIC surgery ,POLYETHYLENE ,POSTOPERATIVE period ,DATA analysis software ,CONFIDENCE intervals ,MENTAL depression ,TIME ,PROSTHESIS design & construction ,SELF-perception - Abstract
Objectives: To assess the overall mental health of enucleated or eviscerated patients after high-density porous polyethylene OCULFIT implantation and external prosthesis over a 1-year follow-up. Methods: Patients with an indication of enucleation or evisceration with OCULFIT implantation were included in a prospective study. The patients completed four questionnaires regarding mental health at three different visits (baseline, 3–6 months, and 9–12 months post-surgery). The questionnaires used were the following: SF-12 for multidimensional health-related quality of life (scale 0–100); Rosemberg self-esteem scale (scale 0–40); Patients Health Questionnaire-4 (PHQ-4) (scale 0–6); and a Lifetime Major Depression and Anhedonia questionnaire (categorised in groups with/without symptoms). Results: A total of 33 patients (16 enucleations and 17 eviscerations) were included in the study. The physical domain of the SF-12 questionnaire did not change between visits, but the mental domain significantly improved from the baseline to the last visit (41.71 ± 12.72 vs. 46.80 ± 10.68, p = 0.04). The number of patients with high, moderate, and low self-esteem (Rosemberg scale) was similar between the baseline and the last visit. The depression and anxiety scores of the PHQ-4 were not significantly different among visits. The number of patients with no symptoms (depression or anhedonia) improved from the baseline (42.2%) throughout the follow-up (66.7% at the last visit). Conclusions: OCULFIT orbital implant and external prosthesis placement maintained and/or improved the quality of life related to mental health in eviscerated and enucleated eyes. The number of patients with no symptoms improved from the baseline throughout the follow-up. The patients' self-esteem was already high before implantation and remained stable over the follow-up. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
6. Novel technique for late scleromalacia in a ciliary body melanoma due to brachytherapy
- Author
-
Relimpio-López, María Isabel, primary, Gessa-Sorroche, María, additional, and Garrido-Hermosilla, Antonio Manuel, additional
- Published
- 2022
- Full Text
- View/download PDF
7. Novel technique for late scleromalacia in a ciliary body melanoma due to brachytherapy.
- Author
-
Relimpio-López, María Isabel, Gessa-Sorroche, María, and Garrido-Hermosilla, Antonio Manuel
- Published
- 2023
- Full Text
- View/download PDF
8. Hyperspectral image processing for the identification and quantification of lentiviral particles in fluid samples
- Author
-
Biomedicina, Biotecnología y Salud Pública, Gómez‑González, Emilio, Fernández‑Muñoz, Beatriz, Barriga‑Rivera, Alejandro, Navas‑García, José Manuel, Fernández‑Lizaranzu, Isabel, Munoz‑González, Francisco Javier, Parrilla‑Giráldez, Rubén, Requena‑Lancharro, Desiree, Guerrero‑Claro, Manuel, Gil‑Gamboa, Pedro, Rosell‑Valle, Crsitina, Gómez‑González, Carmen, Mayorga‑Buiza, Maria José, Martín‑López, María, Muñoz, Olga, Gómez Martín, Juan Carlos, Relimpio López, María Isabel, Aceituno‑Castro, Jesús, Perales‑Esteve, Manuel A., Puppo‑Moreno, Antonio, García Cózar, Francisco José, Olvera Collantes, Lucía, de los Santos‑Trigo, Silvia, Gómez, Emilia, Sánchez Pernaute, Rosario, Padillo‑Ruiz, Javier, Márquez‑Rivas, Javier, Biomedicina, Biotecnología y Salud Pública, Gómez‑González, Emilio, Fernández‑Muñoz, Beatriz, Barriga‑Rivera, Alejandro, Navas‑García, José Manuel, Fernández‑Lizaranzu, Isabel, Munoz‑González, Francisco Javier, Parrilla‑Giráldez, Rubén, Requena‑Lancharro, Desiree, Guerrero‑Claro, Manuel, Gil‑Gamboa, Pedro, Rosell‑Valle, Crsitina, Gómez‑González, Carmen, Mayorga‑Buiza, Maria José, Martín‑López, María, Muñoz, Olga, Gómez Martín, Juan Carlos, Relimpio López, María Isabel, Aceituno‑Castro, Jesús, Perales‑Esteve, Manuel A., Puppo‑Moreno, Antonio, García Cózar, Francisco José, Olvera Collantes, Lucía, de los Santos‑Trigo, Silvia, Gómez, Emilia, Sánchez Pernaute, Rosario, Padillo‑Ruiz, Javier, and Márquez‑Rivas, Javier
- Abstract
Optical spectroscopic techniques have been commonly used to detect the presence of biofilm-forming pathogens (bacteria and fungi) in the agro-food industry. Recently, near-infrared (NIR) spectroscopy revealed that it is also possible to detect the presence of viruses in animal and vegetal tissues. Here we report a platform based on visible and NIR (VNIR) hyperspectral imaging for non-contact, reagent free detection and quantification of laboratory-engineered viral particles in fluid samples (liquid droplets and dry residue) using both partial least square-discriminant analysis and artificial feed-forward neural networks. The detection was successfully achieved in preparations of phosphate buffered solution and artificial saliva, with an equivalent pixel volume of 4 nL and lowest concentration of 800 TU.mu L-1. This method constitutes an innovative approach that could be potentially used at point of care for rapid mass screening of viral infectious diseases and monitoring of the SARS-CoV- 2 pandemic.
- Published
- 2021
9. Artificial intelligence in medicine and healthcare: a review and classification of current and near-future applications and their ethical and social Impact
- Author
-
Universidad de Sevilla. Departamento de Física Aplicada III, Universidad de Sevilla. Departamento de Anatomía y Embriología Humana, Universidad de Sevilla. TEP203: Fisica Interdisciplinar Fundamentos y Aplicaciones, Gómez-González, Emilio, Gómez, Emilia, Márquez Rivas, Javier, Guerrero-Claro, Manuel, Fernández-Lizaranzu, Isabel, Relimpio-López, María Isabel, Dorado, Manuel E., Mayorga-Buiza, M.J., Izquierdo Ayuso, Guillermo, Capitan-Morales, Luis-Cristobal, Universidad de Sevilla. Departamento de Física Aplicada III, Universidad de Sevilla. Departamento de Anatomía y Embriología Humana, Universidad de Sevilla. TEP203: Fisica Interdisciplinar Fundamentos y Aplicaciones, Gómez-González, Emilio, Gómez, Emilia, Márquez Rivas, Javier, Guerrero-Claro, Manuel, Fernández-Lizaranzu, Isabel, Relimpio-López, María Isabel, Dorado, Manuel E., Mayorga-Buiza, M.J., Izquierdo Ayuso, Guillermo, and Capitan-Morales, Luis-Cristobal
- Abstract
This paper provides an overview of the current and near-future applications of Artificial Intelligence (AI) in Medicine and Health Care and presents a classification according to their ethical and societal aspects, potential benefits and pitfalls, and issues that can be considered controversial and are not deeply discussed in the literature. This work is based on an analysis of the state of the art of research and technology, including existing software, personal monitoring devices, genetic tests and editing tools, personalized digital models, online platforms, augmented reality devices, and surgical and companion robotics. Motivated by our review, we present and describe the notion of “extended personalized medicine”, we then review existing applications of AI in medicine and healthcare and explore the public perception of medical AI systems, and how they show, simultaneously, extraordinary opportunities and drawbacks that even question fundamental medical concepts. Many of these topics coincide with urgent priorities recently defined by the World Health Organization for the coming decade. In addition, we study the transformations of the roles of doctors and patients in an age of ubiquitous information, identify the risk of a division of Medicine into “fake-based”, “patient-generated”, and “scientifically tailored”, and draw the attention of some aspects that need further thorough analysis and public debate.
- Published
- 2020
10. Artificial intelligence in medicine and healthcare: a review and classification of current and near-future applications and their ethical and social Impact
- Author
-
Universidad de Sevilla. Departamento de Cirugía, Gómez-González, Emilio, Gómez, Emilia, Márquez-Rivas, Javier, Guerrero-Claro, Manuel, Fernández-Lizaranzu, Isabel, Relimpio-López, María Isabel, Dorado-Ocaña, Manuel E., Mayorga Buiza, María José, Izquierdo Ayuso, Guillermo, Capitan-Morales, Luis-Cristobal, Universidad de Sevilla. Departamento de Cirugía, Gómez-González, Emilio, Gómez, Emilia, Márquez-Rivas, Javier, Guerrero-Claro, Manuel, Fernández-Lizaranzu, Isabel, Relimpio-López, María Isabel, Dorado-Ocaña, Manuel E., Mayorga Buiza, María José, Izquierdo Ayuso, Guillermo, and Capitan-Morales, Luis-Cristobal
- Abstract
This paper provides an overview of the current and near-future applications of Artificial Intelligence (AI) in Medicine and Health Care and presents a classification according to their ethical and societal aspects, potential benefits and pitfalls, and issues that can be considered controversial and are not deeply discussed in the literature. This work is based on an analysis of the state of the art of research and technology, including existing software, personal monitoring devices, genetic tests and editing tools, personalized digital models, online platforms, augmented reality devices, and surgical and companion robotics. Motivated by our review, we present and describe the notion of “extended personalized medicine”, we then review existing applications of AI in medicine and healthcare and explore the public perception of medical AI systems, and how they show, simultaneously, extraordinary opportunities and drawbacks that even question fundamental medical concepts. Many of these topics coincide with urgent priorities recently defined by the World Health Organization for the coming decade. In addition, we study the transformations of the roles of doctors and patients in an age of ubiquitous information, identify the risk of a division of Medicine into “fake-based”, “patient-generated”, and “scientifically tailored”, and draw the attention of some aspects that need further thorough analysis and public debate.
- Published
- 2020
11. Sclerouvectomy plus intraoperative ophthalmic brachytherapy for iris-ciliary body melanomas
- Author
-
Relimpio-López, María Isabel, primary, Garrido-Hermosilla, Antonio Manuel, additional, Espejo-Arjona, Francisco, additional, Coca-Gutiérrez, Lourdes María, additional, Díaz-Granda, María Jesús, additional, and Rodríguez-de-la-Rúa-Franch, Enrique, additional
- Published
- 2021
- Full Text
- View/download PDF
12. Intravitreal air bubble during exoresection of an iris-ciliary body melanoma
- Author
-
Relimpio-López, María Isabel, primary and Garrido-Hermosilla, Antonio Manuel, additional
- Published
- 2019
- Full Text
- View/download PDF
13. Extreme Surgical Maneuvers in Fungal Endophthalmitis
- Author
-
Relimpio-López, María Isabel, primary, Gessa-Sorroche, María, additional, Garrido-Hermosilla, Antonio Manuel, additional, Díaz-Ruiz, Concepción, additional, Montero-Iruzubieta, Jesús, additional, Etxebarría-Ecenarro, Jaime, additional, Ruiz-Casas, Diego, additional, and Rodríguez-de-la-Rúa-Franch, Enrique, additional
- Published
- 2017
- Full Text
- View/download PDF
14. Delayed Boston Keratoprosthesis Exchange due to a Preceding Vitreoretinal Surgery with Intraoperative Choroidal Detachment
- Author
-
Relimpio López, María Isabel, primary, Gessa Sorroche, María, additional, Garrido Hermosilla, Antonio Manuel, additional, Laborda Guirao, Teresa, additional, Espejo Arjona, Francisco, additional, and Rodríguez de la Rúa Franch, Enrique, additional
- Published
- 2015
- Full Text
- View/download PDF
15. Surgical Approaches for Vitreomacular Tractions
- Author
-
Relimpio López, María Isabel, primary, Espejo Arjona, Francisco, additional, Garrido Hermosilla, Antonio Manuel, additional, Laborda Guirao, Teresa, additional, Gómez Escobar, Antonio José, additional, and Rodríguez de la Rúa Franch, Enrique, additional
- Published
- 2015
- Full Text
- View/download PDF
16. Extreme Surgical Maneuvers in Fungal Endophthalmitis.
- Author
-
Relimpio-López, María Isabel, Gessa-Sorroche, María, Garrido-Hermosilla, Antonio Manuel, Díaz-Ruiz, Concepción, Montero-Iruzubieta, Jesús, Etxebarría-Ecenarro, Jaime, Ruiz-Casas, Diego, and Rodríguez-de-la-Rúa-Franch, Enrique
- Subjects
- *
EYE diseases , *CORNEA surgery , *VITRECTOMY , *THERAPEUTICS - Abstract
To present the different evolution of 2 cases of endophthalmitis caused by Fusarium solani, an aggressive filamentous fungus, depending on the medical and surgical treatment performed.Purpose: We present 2 cases of endophthalmitis caused by Fusarium solani. Topical, intrastromal, intravitreal, and systemic antifungal treatment (natamycin, voriconazole, amphotericin B) failed in both cases. Corneal perforation took place in one of them, being unsuccessfully treated with cyanoacrylate and several amniotic membrane transplants. It became necessary to perform a hot penetrating keratoplasty (PK) in both patients. The lenses were removed, and the microbiological analysis showed their colonization by Fusarium solani. In one of the cases, a second PK and a more aggressive pars plana vitrectomy (PPV) were performed after corneal recurrence detected by confocal microscopy, as well as the following therapeutic intra- and postoperative maneuvers: anterior chamber washing with povidone-iodine 5% for 1 min; iridectomy of the infiltrated regions; aspiration of the fungal colonies with vitrector; several air/fluid/amphotericin/voriconazole exchanges during PPV; endodiathermy and endophotocoagulation of the chorioretinitis foci; and intrascleral angle injections of voriconazole and amphotericin.Methods: These were the only cases of endophthalmitis caused by Fusarium attended to at our hospital during the last 10 years. In the case in which PPV was performed without those maneuvers, endophthalmitis rapidly recurred in a more aggressive way, so finally it became necessary to eviscerate the globe. On the other hand, in the patient who underwent PPV with the specific surgical maneuvers and postoperative procedures described above, we could preserve the eye and even a vision of hand motion without an intraocular lens.Results: The main objectives of these surgical procedures are to control the fungal infection and to preserve the ocular globe. It is essential to eliminate all ocular structures (iris, lens, vitreous, etc.) affected by this strain of fungus in order to reduce the risk of recurrence. When indicated, early surgery with the appropriate maneuvers detailed above may make an evisceration unnecessary and even recover some visual acuity. [ABSTRACT FROM AUTHOR]Conclusions: - Published
- 2018
- Full Text
- View/download PDF
17. Delayed Boston Keratoprosthesis Exchange due to a Preceding Vitreoretinal Surgery with Intraoperative Choroidal Detachment.
- Author
-
Relimpio López, María Isabel, Gessa Sorroche, María, Garrido Hermosilla, Antonio Manuel, Laborda Guirao, Teresa, Espejo Arjona, Francisco, and Rodríguez de la Rúa Franch, Enrique
- Subjects
- *
VITREOUS body surgery , *CHOROID diseases , *ANTERIOR eye segment , *POSTERIOR segment (Eye) , *STEVENS-Johnson Syndrome , *SURGERY - Abstract
Purpose: The aim is to describe the main characteristics of an anterior/posterior segment surgery and how to resolve intraoperative complications. Setting/Venue: The anterior and posterior segment surgical video was created at the Department of Ophthalmology, Virgin Macarena University Hospital, Seville, Spain. Methods: We present the case of a male with Stevens-Johnson syndrome and severe limbal deficiency who needed a Boston type 1 keratoprosthesis, reaching a visual acuity of 0.4 (0.05 before surgery). In the course of follow-up, he developed corneal melting with perforation, immune vitritis, and a large epimacular membrane. We decided to perform a 23-gauge vitrectomy associated with keratoprosthesis exchange. As a consequence of inappropriate anesthesia, the patient woke up during the surgery, provoking a retinal tear besides a choroidal detachment. These damages needed endolaser photocoagulation as well as silicone oil tamponade, forcing us to postpone the exchange. An intravitreal dexamethasone implant was also injected. Two months later, the silicone oil was removed, and the Boston keratoprosthesis was replaced by a new type 1 model with a titanium back plate, which likely improves biocompatibility and retention and may reduce complications such as retroprosthetic membranes and stromal corneal melts. Results: Good anatomical results were achieved, and visual acuity slightly improved to 0.2. Conclusions: Combined anterior and posterior segment surgery represents a great challenge that can improve not only visual acuity but also quality of life in patients with severe diseases such as Stevens-Johnson syndrome. © 2015 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
18. Surgical Approaches for Vitreomacular Tractions.
- Author
-
Relimpio López, María Isabel, Espejo Arjona, Francisco, Garrido Hermosilla, Antonio Manuel, Laborda Guirao, Teresa, Gómez Escobar, Antonio José, and Rodríguez de la Rúa Franch, Enrique
- Subjects
- *
EYE diseases , *VITREOUS body surgery , *POSTERIOR segment (Eye) , *RETINAL diseases , *OPHTHALMOLOGY - Abstract
Purpose: The aim is to describe the main characteristics of different approaches in vitreomacular traction surgery. Setting/Venue: The video (see www.karger.com/doi/10.1159/ 000442579) about vitreomacular traction surgery was created at the Department of Ophthalmology, Virgin Macarena University Hospital, Seville, Spain. Methods: We present the surgical release of vitreomacular tractions in three different pathologies: (1) idiopathic epimacular membrane; (2) proliferative diabetic retinopathy with long-term hemovitreous, and (3) Coats' disease. Results: Although functional success is less common than anatomical success, we will never be able to improve vision without restoring retinal anatomy. Conclusions: Vitreomacular tractions are perfectly well known by ophthalmologists. However, the method used to release them must be the least aggressive possible in order to avoid retinal tears or macular holes with subsequent visual loss. © 2015 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.