Author: "Rekhtman, N." - Searchworks@Jio Institute Digital Library Search Results

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328 results on '"Rekhtman, N."'

1. Clinical and molecular correlates of PD-L1 expression in patients with lung adenocarcinomas

Author: Schoenfeld, A.J., Rizvi, H., Bandlamudi, C., Sauter, J.L., Travis, W.D., Rekhtman, N., Plodkowski, A.J., Perez-Johnston, R., Sawan, P., Beras, A., Egger, J.V., Ladanyi, M., Arbour, K.C., Rudin, C.M., Riely, G.J., Taylor, B.S., Donoghue, M.T.A., and Hellmann, M.D.
Published: 2020
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2. Evolutionary characterization of lung adenocarcinoma morphology in TRACERx

Author: Karasaki, T, Moore, D, Veeriah, S, Naceur-Lombardelli, C, Toncheva, A, Magno, N, Ward, S, Bakir, M, Watkins, T, Grigoriadis, K, Huebner, A, Hill, M, Frankell, A, Abbosh, C, Puttick, C, Zhai, H, Gimeno-Valiente, F, Saghafinia, S, Kanu, N, Dietzen, M, Pich, O, Lim, E, Martinez-Ruiz, C, Black, J, Biswas, D, Campbell, B, Lee, C, Colliver, E, Enfield, K, Hessey, S, Hiley, C, Zaccaria, S, Litchfield, K, Birkbak, N, Cadieux, E, Demeulemeester, J, Van Loo, P, Adusumilli, P, Tan, K, Cheema, W, Sanchez-Vega, F, Jones, D, Rekhtman, N, Travis, W, Hackshaw, A, Marafioti, T, Salgado, R, Le Quesne, J, Nicholson, A, Lester, J, Bajaj, A, Nakas, A, Sodha-Ramdeen, A, Ang, K, Tufail, M, Chowdhry, M, Scotland, M, Boyles, R, Rathinam, S, Wilson, C, Marrone, D, Dulloo, S, Fennell, D, Matharu, G, Shaw, J, Riley, J, Primrose, L, Boleti, E, Cheyne, H, Khalil, M, Richardson, S, Cruickshank, T, Price, G, Kerr, K, Benafif, S, Gilbert, K, Naidu, B, Patel, A, Osman, A, Lacson, C, Langman, G, Shackleford, H, Djearaman, M, Kadiri, S, Middleton, G, Leek, A, Hodgkinson, J, Totten, N, Montero, A, Smith, E, Fontaine, E, Granato, F, Doran, H, Novasio, J, Rammohan, K, Joseph, L, Bishop, P, Shah, R, Moss, S, Joshi, V, Crosbie, P, Gomes, F, Brown, K, Carter, M, Chaturvedi, A, Priest, L, Oliveira, P, Lindsay, C, Blackhall, F, Krebs, M, Summers, Y, Clipson, A, Tugwood, J, Kerr, A, Rothwell, D, Kilgour, E, Dive, C, Aerts, H, Schwarz, R, Kaufmann, T, Wilson, G, Rosenthal, R, Szallasi, Z, Kisistok, J, Sokac, M, Diossy, M, Bunkum, A, Stewart, A, Magness, A, Rowan, A, Karamani, A, Chain, B, Castignani, C, Bailey, C, Weeden, C, Richard, C, Pearce, D, Karagianni, D, Levi, D, Hoxha, E, Nye, E, Gronroos, E, Galvez-Cancino, F, Athanasopoulou, F, Kassiotis, G, Stavrou, G, Mastrokalos, G, Lowe, H, Matos, I, Goldman, J, Reading, J, Herrero, J, Rane, J, Nicod, J, Lam, J, Hartley, J, Peggs, K, Selvaraju, K, Thol, K, Ng, K, Chen, K, Dijkstra, K, Thakkar, K, Ensell, L, Shah, M, Duran, M, Litovchenko, M, Sunderland, M, Leung, M, Escudero, M, Angelova, M, Tanic, M, Sivakumar, M, Chervova, O, Lucas, O, Al-Sawaf, O, Prymas, P, Hobson, P, Pawlik, P, Stone, R, Bentham, R, Hynds, R, Vendramin, R, Lopez, S, Gamble, S, Ung, S, Quezada, S, Vanloo, S, Boeing, S, Beck, S, Bola, S, Denner, T, Mourikis, T, Spanswick, V, Barbe, V, Lu, W, Hill, W, Liu, W, Wu, Y, Naito, Y, Ramsden, Z, Veiga, C, Royle, G, Collins-Fekete, C, Fraioli, F, Ashford, P, Clark, T, Forster, M, Lee, S, Borg, E, Falzon, M, Papadatos-Pastos, D, Wilson, J, Ahmad, T, Procter, A, Ahmed, A, Taylor, M, Nair, A, Lawrence, D, Patrini, D, Navani, N, Thakrar, R, Janes, S, Hoogenboom, E, Monk, F, Holding, J, Choudhary, J, Bhakhri, K, Scarci, M, Hayward, M, Panagiotopoulos, N, Gorman, P, Khiroya, R, Stephens, R, Wong, Y, Bandula, S, Sharp, A, Smith, S, Gower, N, Dhanda, H, Chan, K, Pilotti, C, Leslie, R, Grapa, A, Zhang, H, Abduljabbar, K, Pan, X, Yuan, Y, Chuter, D, Mackenzie, M, Chee, S, Alzetani, A, Cave, J, Scarlett, L, Richards, J, Ingram, P, Austin, S, De Sousa, P, Jordan, S, Rice, A, Raubenheimer, H, Bhayani, H, Ambrose, L, Devaraj, A, Chavan, H, Begum, S, Buderi, S, Kaniu, D, Malima, M, Booth, S, Fernandes, N, Shah, P, Proli, C, Hewish, M, Danson, S, Shackcloth, M, Robinson, L, Russell, P, Blyth, K, Dick, C, Kirk, A, Asif, M, Bilancia, R, Kostoulas, N, Thomas, M, Mcgranahan, N, Swanton, C, Jamal-Hanjani, M, Karasaki T., Moore D. A., Veeriah S., Naceur-Lombardelli C., Toncheva A., Magno N., Ward S., Bakir M. A., Watkins T. B. K., Grigoriadis K., Huebner A., Hill M. S., Frankell A. M., Abbosh C., Puttick C., Zhai H., Gimeno-Valiente F., Saghafinia S., Kanu N., Dietzen M., Pich O., Lim E. L., Martinez-Ruiz C., Black J. R. M., Biswas D., Campbell B. B., Lee C., Colliver E., Enfield K. S. S., Hessey S., Hiley C. T., Zaccaria S., Litchfield K., Birkbak N. J., Cadieux E. L., Demeulemeester J., Van Loo P., Adusumilli P. S., Tan K. S., Cheema W., Sanchez-Vega F., Jones D. R., Rekhtman N., Travis W. D., Hackshaw A., Marafioti T., Salgado R., Le Quesne J., Nicholson A. G., Lester J. F., Bajaj A., Nakas A., Sodha-Ramdeen A., Ang K., Tufail M., Chowdhry M. F., Scotland M., Boyles R., Rathinam S., Wilson C., Marrone D., Dulloo S., Fennell D. A., Matharu G., Shaw J. A., Riley J., Primrose L., Boleti E., Cheyne H., Khalil M., Richardson S., Cruickshank T., Price G., Kerr K. M., Benafif S., Gilbert K., Naidu B., Patel A. J., Osman A., Lacson C., Langman G., Shackleford H., Djearaman M., Kadiri S., Middleton G., Leek A., Hodgkinson J. D., Totten N., Montero A., Smith E., Fontaine E., Granato F., Doran H., Novasio J., Rammohan K., Joseph L., Bishop P., Shah R., Moss S., Joshi V., Crosbie P., Gomes F., Brown K., Carter M., Chaturvedi A., Priest L., Oliveira P., Lindsay C. R., Blackhall F. H., Krebs M. G., Summers Y., Clipson A., Tugwood J., Kerr A., Rothwell D. G., Kilgour E., Dive C., Aerts H. J. W. L., Schwarz R. F., Kaufmann T. L., Wilson G. A., Rosenthal R., Szallasi Z., Kisistok J., Sokac M., Diossy M., Bunkum A., Stewart A., Magness A., Rowan A., Karamani A., Chain B., Castignani C., Bailey C., Weeden C. E., Richard C., Pearce D. R., Karagianni D., Levi D., Hoxha E., Nye E., Gronroos E., Galvez-Cancino F., Athanasopoulou F., Kassiotis G., Stavrou G., Mastrokalos G., Lowe H. L., Matos I. G., Goldman J., Reading J. L., Herrero J., Rane J. K., Nicod J., Lam J. M., Hartley J. A., Peggs K. S., Selvaraju K., Thol K., Ng K. W., Chen K., Dijkstra K., Thakkar K., Ensell L., Shah M., Duran M. V., Litovchenko M., Sunderland M. W., Leung M., Escudero M., Angelova M., Tanic M., Sivakumar M., Chervova O., Lucas O., Al-Sawaf O., Prymas P., Hobson P., Pawlik P., Stone R. K., Bentham R., Hynds R. E., Vendramin R., Lopez S., Gamble S., Ung S. K. A., Quezada S. A., Vanloo S., Boeing S., Beck S., Bola S. K., Denner T., Mourikis T. P., Spanswick V., Barbe V., Lu W. -T., Hill W., Liu W. K., Wu Y., Naito Y., Ramsden Z., Veiga C., Royle G., Collins-Fekete C. -A., Fraioli F., Ashford P., Clark T., Forster M. D., Lee S. M., Borg E., Falzon M., Papadatos-Pastos D., Wilson J., Ahmad T., Procter A. J., Ahmed A., Taylor M. N., Nair A., Lawrence D., Patrini D., Navani N., Thakrar R. M., Janes S. M., Hoogenboom E. M., Monk F., Holding J. W., Choudhary J., Bhakhri K., Scarci M., Hayward M., Panagiotopoulos N., Gorman P., Khiroya R., Stephens R. C., Wong Y. N. S., Bandula S., Sharp A., Smith S., Gower N., Dhanda H. K., Chan K., Pilotti C., Leslie R., Grapa A., Zhang H., AbdulJabbar K., Pan X., Yuan Y., Chuter D., MacKenzie M., Chee S., Alzetani A., Cave J., Scarlett L., Richards J., Ingram P., Austin S., Lim E., De Sousa P., Jordan S., Rice A., Raubenheimer H., Bhayani H., Ambrose L., Devaraj A., Chavan H., Begum S., Buderi S. I., Kaniu D., Malima M., Booth S., Fernandes N., Shah P., Proli C., Hewish M., Danson S., Shackcloth M. J., Robinson L., Russell P., Blyth K. G., Dick C., Kirk A., Asif M., Bilancia R., Kostoulas N., Thomas M., McGranahan N., Swanton C., Jamal-Hanjani M., Karasaki, T, Moore, D, Veeriah, S, Naceur-Lombardelli, C, Toncheva, A, Magno, N, Ward, S, Bakir, M, Watkins, T, Grigoriadis, K, Huebner, A, Hill, M, Frankell, A, Abbosh, C, Puttick, C, Zhai, H, Gimeno-Valiente, F, Saghafinia, S, Kanu, N, Dietzen, M, Pich, O, Lim, E, Martinez-Ruiz, C, Black, J, Biswas, D, Campbell, B, Lee, C, Colliver, E, Enfield, K, Hessey, S, Hiley, C, Zaccaria, S, Litchfield, K, Birkbak, N, Cadieux, E, Demeulemeester, J, Van Loo, P, Adusumilli, P, Tan, K, Cheema, W, Sanchez-Vega, F, Jones, D, Rekhtman, N, Travis, W, Hackshaw, A, Marafioti, T, Salgado, R, Le Quesne, J, Nicholson, A, Lester, J, Bajaj, A, Nakas, A, Sodha-Ramdeen, A, Ang, K, Tufail, M, Chowdhry, M, Scotland, M, Boyles, R, Rathinam, S, Wilson, C, Marrone, D, Dulloo, S, Fennell, D, Matharu, G, Shaw, J, Riley, J, Primrose, L, Boleti, E, Cheyne, H, Khalil, M, Richardson, S, Cruickshank, T, Price, G, Kerr, K, Benafif, S, Gilbert, K, Naidu, B, Patel, A, Osman, A, Lacson, C, Langman, G, Shackleford, H, Djearaman, M, Kadiri, S, Middleton, G, Leek, A, Hodgkinson, J, Totten, N, Montero, A, Smith, E, Fontaine, E, Granato, F, Doran, H, Novasio, J, Rammohan, K, Joseph, L, Bishop, P, Shah, R, Moss, S, Joshi, V, Crosbie, P, Gomes, F, Brown, K, Carter, M, Chaturvedi, A, Priest, L, Oliveira, P, Lindsay, C, Blackhall, F, Krebs, M, Summers, Y, Clipson, A, Tugwood, J, Kerr, A, Rothwell, D, Kilgour, E, Dive, C, Aerts, H, Schwarz, R, Kaufmann, T, Wilson, G, Rosenthal, R, Szallasi, Z, Kisistok, J, Sokac, M, Diossy, M, Bunkum, A, Stewart, A, Magness, A, Rowan, A, Karamani, A, Chain, B, Castignani, C, Bailey, C, Weeden, C, Richard, C, Pearce, D, Karagianni, D, Levi, D, Hoxha, E, Nye, E, Gronroos, E, Galvez-Cancino, F, Athanasopoulou, F, Kassiotis, G, Stavrou, G, Mastrokalos, G, Lowe, H, Matos, I, Goldman, J, Reading, J, Herrero, J, Rane, J, Nicod, J, Lam, J, Hartley, J, Peggs, K, Selvaraju, K, Thol, K, Ng, K, Chen, K, Dijkstra, K, Thakkar, K, Ensell, L, Shah, M, Duran, M, Litovchenko, M, Sunderland, M, Leung, M, Escudero, M, Angelova, M, Tanic, M, Sivakumar, M, Chervova, O, Lucas, O, Al-Sawaf, O, Prymas, P, Hobson, P, Pawlik, P, Stone, R, Bentham, R, Hynds, R, Vendramin, R, Lopez, S, Gamble, S, Ung, S, Quezada, S, Vanloo, S, Boeing, S, Beck, S, Bola, S, Denner, T, Mourikis, T, Spanswick, V, Barbe, V, Lu, W, Hill, W, Liu, W, Wu, Y, Naito, Y, Ramsden, Z, Veiga, C, Royle, G, Collins-Fekete, C, Fraioli, F, Ashford, P, Clark, T, Forster, M, Lee, S, Borg, E, Falzon, M, Papadatos-Pastos, D, Wilson, J, Ahmad, T, Procter, A, Ahmed, A, Taylor, M, Nair, A, Lawrence, D, Patrini, D, Navani, N, Thakrar, R, Janes, S, Hoogenboom, E, Monk, F, Holding, J, Choudhary, J, Bhakhri, K, Scarci, M, Hayward, M, Panagiotopoulos, N, Gorman, P, Khiroya, R, Stephens, R, Wong, Y, Bandula, S, Sharp, A, Smith, S, Gower, N, Dhanda, H, Chan, K, Pilotti, C, Leslie, R, Grapa, A, Zhang, H, Abduljabbar, K, Pan, X, Yuan, Y, Chuter, D, Mackenzie, M, Chee, S, Alzetani, A, Cave, J, Scarlett, L, Richards, J, Ingram, P, Austin, S, De Sousa, P, Jordan, S, Rice, A, Raubenheimer, H, Bhayani, H, Ambrose, L, Devaraj, A, Chavan, H, Begum, S, Buderi, S, Kaniu, D, Malima, M, Booth, S, Fernandes, N, Shah, P, Proli, C, Hewish, M, Danson, S, Shackcloth, M, Robinson, L, Russell, P, Blyth, K, Dick, C, Kirk, A, Asif, M, Bilancia, R, Kostoulas, N, Thomas, M, Mcgranahan, N, Swanton, C, Jamal-Hanjani, M, Karasaki T., Moore D. A., Veeriah S., Naceur-Lombardelli C., Toncheva A., Magno N., Ward S., Bakir M. A., Watkins T. B. K., Grigoriadis K., Huebner A., Hill M. S., Frankell A. M., Abbosh C., Puttick C., Zhai H., Gimeno-Valiente F., Saghafinia S., Kanu N., Dietzen M., Pich O., Lim E. L., Martinez-Ruiz C., Black J. R. M., Biswas D., Campbell B. B., Lee C., Colliver E., Enfield K. S. S., Hessey S., Hiley C. T., Zaccaria S., Litchfield K., Birkbak N. J., Cadieux E. L., Demeulemeester J., Van Loo P., Adusumilli P. S., Tan K. S., Cheema W., Sanchez-Vega F., Jones D. R., Rekhtman N., Travis W. D., Hackshaw A., Marafioti T., Salgado R., Le Quesne J., Nicholson A. G., Lester J. F., Bajaj A., Nakas A., Sodha-Ramdeen A., Ang K., Tufail M., Chowdhry M. F., Scotland M., Boyles R., Rathinam S., Wilson C., Marrone D., Dulloo S., Fennell D. A., Matharu G., Shaw J. A., Riley J., Primrose L., Boleti E., Cheyne H., Khalil M., Richardson S., Cruickshank T., Price G., Kerr K. M., Benafif S., Gilbert K., Naidu B., Patel A. J., Osman A., Lacson C., Langman G., Shackleford H., Djearaman M., Kadiri S., Middleton G., Leek A., Hodgkinson J. D., Totten N., Montero A., Smith E., Fontaine E., Granato F., Doran H., Novasio J., Rammohan K., Joseph L., Bishop P., Shah R., Moss S., Joshi V., Crosbie P., Gomes F., Brown K., Carter M., Chaturvedi A., Priest L., Oliveira P., Lindsay C. R., Blackhall F. H., Krebs M. G., Summers Y., Clipson A., Tugwood J., Kerr A., Rothwell D. G., Kilgour E., Dive C., Aerts H. J. W. L., Schwarz R. F., Kaufmann T. L., Wilson G. A., Rosenthal R., Szallasi Z., Kisistok J., Sokac M., Diossy M., Bunkum A., Stewart A., Magness A., Rowan A., Karamani A., Chain B., Castignani C., Bailey C., Weeden C. E., Richard C., Pearce D. R., Karagianni D., Levi D., Hoxha E., Nye E., Gronroos E., Galvez-Cancino F., Athanasopoulou F., Kassiotis G., Stavrou G., Mastrokalos G., Lowe H. L., Matos I. G., Goldman J., Reading J. L., Herrero J., Rane J. K., Nicod J., Lam J. M., Hartley J. A., Peggs K. S., Selvaraju K., Thol K., Ng K. W., Chen K., Dijkstra K., Thakkar K., Ensell L., Shah M., Duran M. V., Litovchenko M., Sunderland M. W., Leung M., Escudero M., Angelova M., Tanic M., Sivakumar M., Chervova O., Lucas O., Al-Sawaf O., Prymas P., Hobson P., Pawlik P., Stone R. K., Bentham R., Hynds R. E., Vendramin R., Lopez S., Gamble S., Ung S. K. A., Quezada S. A., Vanloo S., Boeing S., Beck S., Bola S. K., Denner T., Mourikis T. P., Spanswick V., Barbe V., Lu W. -T., Hill W., Liu W. K., Wu Y., Naito Y., Ramsden Z., Veiga C., Royle G., Collins-Fekete C. -A., Fraioli F., Ashford P., Clark T., Forster M. D., Lee S. M., Borg E., Falzon M., Papadatos-Pastos D., Wilson J., Ahmad T., Procter A. J., Ahmed A., Taylor M. N., Nair A., Lawrence D., Patrini D., Navani N., Thakrar R. M., Janes S. M., Hoogenboom E. M., Monk F., Holding J. W., Choudhary J., Bhakhri K., Scarci M., Hayward M., Panagiotopoulos N., Gorman P., Khiroya R., Stephens R. C., Wong Y. N. S., Bandula S., Sharp A., Smith S., Gower N., Dhanda H. K., Chan K., Pilotti C., Leslie R., Grapa A., Zhang H., AbdulJabbar K., Pan X., Yuan Y., Chuter D., MacKenzie M., Chee S., Alzetani A., Cave J., Scarlett L., Richards J., Ingram P., Austin S., Lim E., De Sousa P., Jordan S., Rice A., Raubenheimer H., Bhayani H., Ambrose L., Devaraj A., Chavan H., Begum S., Buderi S. I., Kaniu D., Malima M., Booth S., Fernandes N., Shah P., Proli C., Hewish M., Danson S., Shackcloth M. J., Robinson L., Russell P., Blyth K. G., Dick C., Kirk A., Asif M., Bilancia R., Kostoulas N., Thomas M., McGranahan N., Swanton C., and Jamal-Hanjani M.
Abstract: Lung adenocarcinomas (LUADs) display a broad histological spectrum from low-grade lepidic tumors through to mid-grade acinar and papillary and high-grade solid, cribriform and micropapillary tumors. How morphology reflects tumor evolution and disease progression is poorly understood. Whole-exome sequencing data generated from 805 primary tumor regions and 121 paired metastatic samples across 248 LUADs from the TRACERx 421 cohort, together with RNA-sequencing data from 463 primary tumor regions, were integrated with detailed whole-tumor and regional histopathological analysis. Tumors with predominantly high-grade patterns showed increased chromosomal complexity, with higher burden of loss of heterozygosity and subclonal somatic copy number alterations. Individual regions in predominantly high-grade pattern tumors exhibited higher proliferation and lower clonal diversity, potentially reflecting large recent subclonal expansions. Co-occurrence of truncal loss of chromosomes 3p and 3q was enriched in predominantly low-/mid-grade tumors, while purely undifferentiated solid-pattern tumors had a higher frequency of truncal arm or focal 3q gains and SMARCA4 gene alterations compared with mixed-pattern tumors with a solid component, suggesting distinct evolutionary trajectories. Clonal evolution analysis revealed that tumors tend to evolve toward higher-grade patterns. The presence of micropapillary pattern and ‘tumor spread through air spaces’ were associated with intrathoracic recurrence, in contrast to the presence of solid/cribriform patterns, necrosis and preoperative circulating tumor DNA detection, which were associated with extra-thoracic recurrence. These data provide insights into the relationship between LUAD morphology, the underlying evolutionary genomic landscape, and clinical and anatomical relapse risk.
Published: 2023

3. OA20.05 The International Association for the Study of Lung Cancer Grading System for Recurrence and Lung Cancer-Specific Survival

Author: Tan, K.S., primary, Reiner, A., additional, Emoto, K., additional, Aly, R.G., additional, Rekhtman, N., additional, Adusumilli, P., additional, and Travis, W., additional
Published: 2023
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4. PD-L1 expression, tumor mutational burden, and response to immunotherapy in patients with MET exon 14 altered lung cancers

Author: Sabari, J.K., Leonardi, G.C., Shu, C.A., Umeton, R., Montecalvo, J., Ni, A., Chen, R., Dienstag, J., Mrad, C., Bergagnini, I., Lai, W.V., Offin, M., Arbour, K.C., Plodkowski, A.J., Halpenny, D.F., Paik, P.K., Li, B.T., Riely, G.J., Kris, M.G., Rudin, C.M., Sholl, L.M., Nishino, M., Hellmann, M.D., Rekhtman, N., Awad, M.M., and Drilon, A.
Published: 2018
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5. Clinical outcomes with pemetrexed-based systemic therapies in RET-rearranged lung cancers

Author: Drilon, A., Bergagnini, I., Delasos, L., Sabari, J., Woo, K.M., Plodkowski, A., Wang, L., Hellmann, M.D., Joubert, P., Sima, C.S., Smith, R., Somwar, R., Rekhtman, N., Ladanyi, M., Riely, G.J., and Kris, M.G.
Published: 2016
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6. EP16.03-030 AKT Inhibition as a Therapeutic Strategy to Constrain Histological Transdifferentiation in EGFR-mutant Lung Adenocarcinoma.

Author: Quintanal-Villalonga, A., primary, Taniguchi, H., additional, Zhan, Y.A., additional, Rekhtman, N., additional, Houck-Loomis, B., additional, Koche, R.P., additional, Yu, H.A., additional, Sen, T., additional, and Rudin, C.M., additional
Published: 2022
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7. P3.03I.07 Comprehensive Pan-Cancer Analysis of Oncogenic MET Rearrangements with a Focus on Targetability in NSCLC

Author: Vojnic, M., Febres-Aldana, C.A., Odintsov, I., Zhang, T., Beach, C.Z., Lu, D., Mattar, M.S., Gazzo, A., Gili, L., Harshan, M., Ameri, A., Machnicki, S., Xiao, X., Lockwood, W.W., Zhou, X., Yao, Q., Drilon, A., Rekhtman, N., Shah, N., Li, A., Liu, Z., Yang, S.-R., Davare, M.A., Ladanyi, M., and Somwar, R.
Published: 2024
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8. OA18.06 Characteristics and Outcomes of Patients with SMARCA4-Deficient Undifferentiated Thoracic Tumors

Author: Cooper, A., Ricciuti, B., Gagne, A., Sholl, L., Di Federico, A., Awad, M., Aldea, M., Ghigna, M.R., Grecea, M., Chaft, J., Kris, M., Riely, G., Rudin, C., Dagogo-Jack, I., Mino-Kenudson, M., Hong, L., Kalhor, N., Vokes, N., Rekhtman, N., and Schoenfeld, A.
Published: 2024
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9. MA11.06 Multi-Omic Characterization of Lung Tumors Implicates AKT and MYC Signaling in Adenocarcinoma to Squamous Cell Transdifferentiation

Author: Quintanal-Villalonga, A., primary, Taniguchi, H., additional, Zhan, Y., additional, Hasan, M., additional, Chavan, S., additional, Uddin, F., additional, Allaj, V., additional, Manoj, P., additional, Shah, N., additional, Chan, J., additional, Chow, A., additional, Offin, M., additional, Bhanot, U., additional, Egger, J., additional, Qiu, J., additional, De Stanchina, E., additional, Chang, J., additional, Rekhtman, N., additional, Houck-Loomis, B., additional, Koche, R., additional, Yu, H., additional, Sen, T., additional, and Rudin, C., additional
Published: 2021
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10. 1MO Multi-omic characterization of lung tumors identify AKT and EZH2 as potential therapeutic targets in adenocarcinoma-to-squamous transdifferentiation

Author: Quintanal-Villalonga, Á., primary, Taniguchi, H., additional, Zhan, Y.A., additional, Hasan, M.M., additional, Chavan, S.S., additional, Uddin, F., additional, Allaj, V., additional, Manoj, P., additional, Shah, N., additional, Ciampricotti, M., additional, Bhanot, U., additional, Egger, J., additional, Qiu, J., additional, De Stanchina, E., additional, Rekhtman, N., additional, Houck-Loomis, B., additional, Koche, R.P., additional, Yu, H.A., additional, Sen, T., additional, and Rudin, C.M., additional
Published: 2021
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11. OA06.01 Validation of the 8th Ed TNM: Invasive Size for Pathologic T Descriptor in Stage I-IIA Resected Nonmucinous Adenocarcinomas

Author: Li, Y., primary, Choe, J., additional, Tan, K.S., additional, Cheema, W., additional, Rekhtman, N., additional, Adusumilli, P., additional, and Travis, W., additional
Published: 2021
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12. 1800O Multi-omic characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation

Author: Quintanal-Villalonga, Á., primary, Taniguchi, H., additional, Zhan, Y.A., additional, Hasan, M.M., additional, Chavan, S.S., additional, Uddin, F., additional, Allaj, V., additional, Manoj, P., additional, Shah, N.S., additional, Chan, J.M., additional, Ciampricotti, M., additional, Chow, A., additional, Bhanot, U., additional, Egger, J., additional, Qiu, J., additional, De Stanchina, E., additional, Rekhtman, N., additional, Yu, H.A., additional, Sen, T., additional, and Rudin, C.M., additional
Published: 2021
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13. 1385P Genomics of early progression on selpercatinib in patients with RET fusion-positive lung cancers

Author: Chen, M.F., Rosen, E., Falcon, C., Repetto, M., Yang, S.R., Chang, J., Kris, M.G., Rekhtman, N., Donoghue, M., and Drilon, A.
Published: 2023
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14. P38.04 3D Analysis of Spread Through Air Spaces in Squamous Cell Carcinoma and Carcinoid Tumor Using Whole Block Imaging by Micro CT

Author: Inoue, T., primary, Teplov, A., additional, Rekhtman, N., additional, Chida, M., additional, Travis, W., additional, and Yagi, Y., additional
Published: 2021
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15. A07 The Genomic Landscape of SMARCA4 Alterations and Association with Patient Outcomes in Lung Cancer

Author: Schoenfeld, A.J., primary, Montecalvo, J., additional, Namakydoust, A., additional, Lavery, J., additional, Bandlamudi, C., additional, Rizvi, H., additional, Paul, S., additional, Arcila, M., additional, Chang, J., additional, Sauter, J., additional, Beras, A., additional, Ladanyi, M., additional, Taylor, B., additional, Donoghue, M., additional, Heller, G., additional, Hellmann, M., additional, Rekhtman, N., additional, and Riely, G., additional
Published: 2020
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16. Cross-Reactivity of EGFR-L858R Mutation-Specific Antibody With HER2 Overexpression in Lung Adenocarcinoma: Report of 2 Index Cases

Author: Leduc, C., Rekhtman, N., Travis, W., Moreira, A., Arcila, M., and Ladanyi, M.
Subjects: Adenocarcinoma -- Genetic aspects, Antigen-antibody reactions, Immunohistochemistry, Gene mutation, Antibodies, Health
Abstract: The L858R point mutation of exon 21 of EGFR accounts for up to 45% of EGFR-mutated lung adenocarcinomas (LACs). EGFR (L858R) mutation-specific antibody has been shown to have high positive predictive value (99%-100%). HER2 amplification is known to be a mechanism of acquired resistance to erlotinib. False-positive staining of EGFR (L858R) by immunohistochemistry (IHC) has been reported in ER+, HER-amplified breast carcinomas, but not in LAC. We identified 2 LACs positive for both EGFR L858R (2-3+) and HER2 (3+) by IHC. Targeted gene sequencing was performed to confirm the underlying molecular abnormality and to uncover potential cross-reactivity. Patient 1 was a 57-year-old man with stage IV LAC. Staging node biopsy showed metastatic adenocarcinoma diffusely positive for EGFR L858R by IHC. Sequencing revealed no EGFR (L858R) mutation, but amplification of HER2. HER2 was also 3+ positive by IHC. Patient 2 was a 52-year-old man with progression while taking erlotinib for LAC with EGFR exon 19 deletion. Rebiopsy of the primary tumor showed focal strong positivity for EGFR (L858R) by IHC, despite lack of EGFR (L858R) mutation by sequencing. HER2 was 3+ by IHC in the same cells that were EGFR L858R positive by IHC. We demonstrate 2 examples of false positivity for EGFR L858R by IHC. Structural homology between HER2 and EGFR might partially explain the cross-reactivity; however, further studies are needed to elucidate the frequency and mechanism of this event., C. Leduc; N. Rekhtman; W. Travis; A. Moreira; M. Arcila; M. Ladanyi. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New [...]
Published: 2016

17. Mucocutaneous bullous amyloidosis with an unusual mixed protein composition of amyloid deposits

Author: Rekhtman, N., Hash, K. S., and Moresi, J. M.
Published: 2006

18. P2.09-24 IASLC Global Survey for Pathologists on PD-L1 Testing for Non-Small Cell Lung Cancer

Author: Mino-Kenudson, M., primary, Redman, M., additional, Hedger, J., additional, Daigneault, J., additional, Botling, J., additional, Brambilla, E., additional, Chen, G., additional, Chou, T., additional, Cooper, W., additional, Hirsch, F.R., additional, Jain, D., additional, Kerr, K., additional, Longshore, J., additional, Lopez-Rios, F., additional, Motoi, N., additional, Pelosi, G., additional, Tsao, M., additional, Yatabe, Y., additional, Beasley, M.B., additional, Borczuk, A., additional, Bubendorf, L., additional, Chung, J., additional, Dacic, S., additional, Hwang, D., additional, Minami, Y., additional, Moreira, A., additional, Nicholson, A., additional, Papotti, M., additional, Poleri, C., additional, Rekhtman, N., additional, Roden, A.C., additional, Russell, P., additional, Sholl, L., additional, Thunnissen, E., additional, Travis, W., additional, Yoshida, A., additional, Wynes, M., additional, Wistuba, I., additional, and Lantuejoul, S., additional
Published: 2019
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19. ES12.05 Impact of STAS in Lung Cancer Staging

Author: Travis, W., primary, Aly, R., additional, Eguchi, T., additional, Rekhtman, N., additional, Yagi, Y., additional, and Adusumilli, P., additional
Published: 2019
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20. P1.04-39 Molecular Characteristics, Immunophenotype, and Immune Checkpoint Inhibitor Response in BRAF Non-V600 Mutant Lung Cancers

Author: Offin, M., primary, Pak, T., additional, Mondaca, S., additional, Montecalvo, J., additional, Rekhtman, N., additional, Halpenny, D., additional, Wu, S., additional, Kris, M., additional, Paik, P., additional, Riely, G., additional, Rudin, C., additional, Hyman, D., additional, Hellmann, M., additional, Drilon, A., additional, Land, J., additional, Buie, L., additional, Lito, P., additional, Yaeger, R., additional, Liu, D., additional, and Li, B., additional
Published: 2019
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21. P1.14-06 Tissue-Based Molecular and Histologic Landscape of Acquired Resistance to Osimertinib in Patients with EGFR-Mutant Lung Cancers

Author: Schoenfeld, A., primary, Chan, J., additional, Rizvi, H., additional, Somwar, R., additional, Kubota, D., additional, Daneshbod, Y., additional, Chang, J., additional, Offin, M., additional, Arcila, M., additional, Pe'Er, D., additional, Kris, M., additional, Rekhtman, N., additional, Riely, G., additional, Ladanyi, M., additional, and Yu, H., additional
Published: 2019
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22. P1.14-50 A Phase 2 Trial of Cabozantinib in ROS1-Rearranged Lung Adenocarcinoma

Author: Guo, R., primary, Preeshagul, I., additional, Schoenfeld, A., additional, Mccarthy, C., additional, Makhnin, A., additional, Plodkowski, A., additional, Ginsberg, M., additional, Davare, M., additional, Delasos, L., additional, Somwar, R., additional, Arcila, M., additional, Riely, G., additional, Rekhtman, N., additional, Ladanyi, M., additional, Kris, M., additional, and Drilon, A., additional
Published: 2019
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23. MA22.05 Impact of Tumor Spread Through Air Spaces (STAS) in Lung Neuroendocrine Tumors (NETs)

Author: Aly, R., primary, Eguchi, T., additional, Kadota, K., additional, Rekhtman, N., additional, Tan, K.S., additional, Adusumilli, P., additional, and Travis, W., additional
Published: 2018
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24. MA16.04 Clinical and Molecular Characteristics of EGFR Mutant Lung Cancers with Concurrent TP53 and RB1 Mutations

Author: Offin, M., primary, Tenet, M., additional, Shen, R., additional, Rekhtman, N., additional, Rizvi, H., additional, Hellmann, M., additional, Arcila, M., additional, Ladanyi, M., additional, Rudin, C., additional, Kris, M., additional, and Yu, H., additional
Published: 2018
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25. MA09.06 The Newly Recognized Filigree Pattern of Micropapillary (MIP) Lung Adenocarcinoma (LADC) is as Clinically Important as the Classical Pattern

Author: Emoto, K., primary, Eguchi, T., additional, Vaghjiani, R., additional, Takahashi, Y., additional, Rekhtman, N., additional, Adusumilli, P., additional, and Travis, W., additional
Published: 2018
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26. MS10.04 Therapeutic Implications of Spread Through Air Spaces (STAS)

Author: Travis, W., primary, Gaber, R., additional, Lu, S., additional, Eguchi, T., additional, Rekhtman, N., additional, and Adusumilli, P., additional
Published: 2018
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27. OA03.07 Three-Dimensional Immunofluorescence Analysis of Dynamic Vessel Co-Option of Spread Through Air Spaces (STAS) in Lung Cancer

Author: Yagi, Y., primary, Aly, R., additional, Tabata, K., additional, Rekhtman, N., additional, Eguchi, T., additional, Montecalvo, J., additional, Manova, K., additional, Adusumilli, P., additional, Hameed, M., additional, and Travis, W., additional
Published: 2018
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28. Pathologic features of response to neoadjuvant anti-PD-1 in resected non-small-cell lung carcinoma: a proposal for quantitative immune-related pathologic response criteria (irPRC)

Author: Cottrell, T.R., primary, Thompson, E.D., additional, Forde, P.M., additional, Stein, J.E., additional, Duffield, A.S., additional, Anagnostou, V., additional, Rekhtman, N., additional, Anders, R.A., additional, Cuda, J.D., additional, Illei, P.B., additional, Gabrielson, E., additional, Askin, F.B., additional, Niknafs, N., additional, Smith, K.N., additional, Velez, M.J., additional, Sauter, J.L., additional, Isbell, J.M., additional, Jones, D.R., additional, Battafarano, R.J., additional, Yang, S.C., additional, Danilova, L., additional, Wolchok, J.D., additional, Topalian, S.L., additional, Velculescu, V.E., additional, Pardoll, D.M., additional, Brahmer, J.R., additional, Hellmann, M.D., additional, Chaft, J.E., additional, Cimino-Mathews, A., additional, and Taube, J.M., additional
Published: 2018
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29. OA 18.06 Three-Dimensional Assessment of Spread Through Air Spaces in Lung Adenocarcinoma: Insights and Implications

Author: Yagi, Y., primary, Tabata, K., additional, Rekhtman, N., additional, Eguchi, T., additional, Fu, X., additional, Montecalvo, J., additional, Adusumilli, P., additional, Hameed, M., additional, and Travis, W., additional
Published: 2017
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30. P3.13-019 Preoperative Needle Biopsy Does Not Increase the Risk of Pleural Recurrence in ≤3cm Lung Adenocarcinoma

Author: Kameda, K., primary, Eguchi, T., additional, Gaber, R., additional, Rekhtman, N., additional, Tano, Z., additional, Solomon, S., additional, Travis, W., additional, Jones, D., additional, and Adusumilli, P., additional
Published: 2017
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31. Adenosquamous carcinoma

Author: Yatabe, Y., Brambilla, E., Rekhtman, N., and van Schil, Paul
Subjects: Human medicine
Published: 2015

32. Prospective Molecular Evaluation of Small Cell Lung Cancer (Sclc) Utilizing the Comprehensive Mutation Analysis Program (Map) at Memorial Sloan Kettering Cancer Center (Mskcc)

Author: Krug, L.M., primary, Pietanza, M.C., additional, Varghese, A.M., additional, Won, H., additional, Wang, L., additional, Rekhtman, N., additional, Travis, W.D., additional, Litvak, A., additional, Paik, P.K., additional, Riely, G.J., additional, Zakowski, M.F., additional, Ladanyi, M., additional, Berger, M.F., additional, Kris, M., additional, and Rudin, C.M., additional
Published: 2014
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33. Large Cell Neuroendocrine Carcinomas (Lcnec) of the Lung: Pathologic Features, Treatment and Outcomes

Author: Naidoo, J., primary, Santos-Zabala, M.L., additional, Iyriboz, T., additional, Woo, K., additional, Sima, C.S., additional, Fiore, J.J., additional, Kris, M., additional, Veach, S.R., additional, Riely, G.J., additional, Iqbal, A., additional, Smith-Marrone, S., additional, Sarkaria, I.S., additional, Krug, L.M., additional, Rudin, C.M., additional, Rekhtman, N., additional, and Pietanza, M.C., additional
Published: 2014
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34. Screening for EGFR, KRAS, and PIK3CA mutations in well-characterized, immunohistochemically confirmed squamous cell carcinoma of lung.

Author: Rekhtman, N., primary, Paik, P. K., additional, Arcila, M. E., additional, Tafe, L. J., additional, Zakowski, M. F., additional, Riely, G. J., additional, Miller, V. A., additional, Kris, M. G., additional, and Ladanyi, M., additional
Published: 2011
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35. Response to EGFR TKIs in never smokers with stage IV EGFR mutant squamous cell carcinoma of the lung (SQCC).

Author: Paik, P. K., primary, Rekhtman, N., additional, Riely, G. J., additional, Miller, V. A., additional, Ladanyi, M., additional, and Kris, M. G., additional
Published: 2011
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36. Reflex testing of lung adenocarcinomas for EGFR and KRAS mutations: The Memorial Sloan-Kettering experience

Author: Zakowski, M. F., primary, Ladanyi, M., additional, Rekhtman, N., additional, Park, B. J., additional, Finley, D., additional, Azzoli, C. G., additional, Riely, G. J., additional, Rusch, V. W., additional, and Kris, M. G., additional
Published: 2008
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37. Comparison of CISH and FISH for detection of EGFR copy number in lung adenocarcinoma and correlation with EGFR and KRAS mutation status and EGFR immunoreactivity

Author: Varella-Garcia, M., primary, Ladanyi, M., additional, Kris, M. G., additional, Li, A., additional, Chitale, D. A., additional, Rekhtman, N., additional, Riely, G. J., additional, Miller, V. A., additional, Hirsch, F. R., additional, and Zakowski, M. F., additional
Published: 2008
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38. Patterns of co-expression of ERCC1 and p27 in resected non-small cell lung cancer by immunohistochemistry

Author: Rekhtman, N., primary, Azzoli, C. G., additional, Kris, M. G., additional, Park, B. J., additional, and Zakowski, M. F., additional
Published: 2008
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39. Mucocutaneous bullous amyloidosis with an unusual mixed protein composition of amyloid deposits

Author: Rekhtman, N., primary, Hash, K.S., additional, and Moresi, J.M., additional
Published: 2005
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40. 1463O - Prospective Molecular Evaluation of Small Cell Lung Cancer (Sclc) Utilizing the Comprehensive Mutation Analysis Program (Map) at Memorial Sloan Kettering Cancer Center (Mskcc)

Author: Krug, L.M., Pietanza, M.C., Varghese, A.M., Won, H., Wang, L., Rekhtman, N., Travis, W.D., Litvak, A., Paik, P.K., Riely, G.J., Zakowski, M.F., Ladanyi, M., Berger, M.F., Kris, M., and Rudin, C.M.
Published: 2014
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41. 1142PD - Large Cell Neuroendocrine Carcinomas (Lcnec) of the Lung: Pathologic Features, Treatment and Outcomes

Author: Naidoo, J., Santos-Zabala, M.L., Iyriboz, T., Woo, K., Sima, C.S., Fiore, J.J., Kris, M., Veach, S.R., Riely, G.J., Iqbal, A., Smith-Marrone, S., Sarkaria, I.S., Krug, L.M., Rudin, C.M., Rekhtman, N., and Pietanza, M.C.
Published: 2014
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42. Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells

Author: Rekhtman, N., primary, Radparvar, F., additional, Evans, T., additional, and Skoultchi, A. I., additional
Published: 1999
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43. p40 ([Delta]Np63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma.

Author: Bishop JA, Teruya-Feldstein J, Westra WH, Pelosi G, Travis WD, and Rekhtman N
Published: 2012
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44. Subtyping of non-small cell lung carcinoma: a comparison of small biopsy and cytology specimens.

Author: Sigel CS, Moreira AL, Travis WD, Zakowski MF, Thornton RH, Riely GJ, Rekhtman N, Sigel, Carlie S, Moreira, Andre L, Travis, William D, Zakowski, Maureen F, Thornton, Raymond H, Riely, Gregory J, and Rekhtman, Natasha
Published: 2011
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45. Suitability of thoracic cytology for new therapeutic paradigms in non-small cell lung carcinoma: high accuracy of tumor subtyping and feasibility of EGFR and KRAS molecular testing.

Author: Rekhtman N, Brandt SM, Sigel CS, Friedlander MA, Riely GJ, Travis WD, Zakowski MF, Moreira AL, Rekhtman, Natasha, Brandt, Suzanne M, Sigel, Carlie S, Friedlander, Maria A, Riely, Gregory J, Travis, William D, Zakowski, Maureen F, and Moreira, Andre L
Published: 2011
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46. Neuroendocrine tumors of the lung: an update.

Author: Rekhtman N
Published: 2010
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47. EGFR exon 20 mutations: Molecular spectrum, incidence and clinicopathologic characteristics

Author: Liu, Y. C., Nafa, K., Chaft, J. E., Rekhtman, N., Reva, B., Zakowski, M. F., Mark Kris, Ladanyi, M., and Arcila, M. E.

48. Prospective molecular evaluation of small cell lung cancer (SCLC) utilizing the comprehensive mutation analysis program (MAP) at Memorial Sloan Kettering Cancer Center (MSKCC)

Author: Krug, L. M., Pietanza, M. C., Varghese, A. M., Won, H., Wang, L., Rekhtman, N., Travis, W. D., Litvak, A., Paik, P. K., Riely, G. J., Zakowski, M. F., Ladanyi, M., Berger, M. F., Mark Kris, and Rudin, C. M.

49. Losing your touch? Depletion of core needle biopsies by touch preparations: Ex-vivo modeling of an adverse consequence of on-site assessment

Author: Kazi, S., Yao, J., Dogan, S., Carlie Sigel, Andrade, P., Lin, O., Silk, M., Silk, T., Durack, J. C., Solomon, S. B., Klimstra, D. S., and Rekhtman, N.

50. Stage IV large cell neuroendocrine carcinoma (LCNEC) of the lung: Clinicopathologic features, treatment, and survival

Author: Naidoo, J., Woo, K., Sima, C. S., Rekhtman, N., Stacy Thomas, Sarkaria, I. S., Rudin, C. M., Krug, L. M., and Pietanza, M. C.

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