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1. Relativistic coupled cluster calculations of the electron affinity and ionization potentials of lawrencium

Author: Guo, Yangyang, Pašteka, Lukáš F, Nagame, Yuichiro, Sato, Tetsuya K., Eliav, Ephraim, Reitsma, Marten L., and Borschevsky, Anastasia
Subjects: Physics - Atomic Physics
Abstract: The calculations of the first and the second ionization potentials of lawrencium and lutetium and the electron affinity of lawrencium are performed within the relativistic coupled cluster framework. These results are corrected by including the contributions of extrapolation to the complete basis set limit and higher order contributions due to relativity and electron correlation. The excellent agreement between our predictions of the ionization potentials of Lu and Lr and experimental values supports the accuracy of our predictions of the second ionization potential and the electron affinity of Lr.
Published: 2024
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2. Under pressure: learning-based analog gauge reading in the wild

Author: Reitsma, Maurits, Keller, Julian, Blomqvist, Kenneth, and Siegwart, Roland
Subjects: Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning, Computer Science - Robotics
Abstract: We propose an interpretable framework for reading analog gauges that is deployable on real world robotic systems. Our framework splits the reading task into distinct steps, such that we can detect potential failures at each step. Our system needs no prior knowledge of the type of gauge or the range of the scale and is able to extract the units used. We show that our gauge reading algorithm is able to extract readings with a relative reading error of less than 2%., Comment: 7 pages, 8 figures, accepted for presentation at the 2024 IEEE International Conference on Robotics and Automation (ICRA) and for inclusion in the conference proceedings, finalist for the IEEE ICRA 2024 Best Paper Award in Automation, source code https://github.com/ethz-asl/analog_gauge_reader, Autonomous Systems Lab, ETH Zurich
Published: 2024

3. Fully-automated segmentation of muscle and inter-/intra-muscular fat from magnetic resonance images of calves and thighs: an open-source workflow in Python

Author: Tam, Kenneth, Liu, Si Wen, Costa, Sarah, Szabo, Eva, Reitsma, Shannon, Gillick, Hana, Adachi, Jonathan D., and Wong, Andy Kin On
Published: 2024
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4. A unified framework for diagnostic test development and evaluation during outbreaks of emerging infections

Author: Chaturvedi, Madhav, Köster, Denise, Bossuyt, Patrick M., Gerke, Oke, Jurke, Annette, Kretzschmar, Mirjam E., Lütgehetmann, Marc, Mikolajczyk, Rafael, Reitsma, Johannes B., Schneiderhan-Marra, Nicole, Siebert, Uwe, Stekly, Carina, Ehret, Christoph, Rübsamen, Nicole, Karch, André, and Zapf, Antonia
Published: 2024
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5. Development and validation of a 66K SNP array for the hard clam (Mercenaria mercenaria)

Author: Grouzdev, Denis, Farhat, Sarah, Guo, Ximing, Espinosa, Emmanuelle Pales, Reece, Kimberly, McDowell, Jan, Yang, Huiping, Rivara, Gregg, Reitsma, Joshua, Clemetson, Antoinette, Tanguy, Arnaud, and Allam, Bassem
Published: 2024
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6. Organic matter degradation in the deep, sulfidic waters of the Black Sea: insights into the ecophysiology of novel anaerobic bacteria

Author: Yadav, Subhash, Koenen, Michel, Bale, Nicole J., Reitsma, Wietse, Engelmann, Julia C., Stefanova, Kremena, Damsté, Jaap S. Sinninghe, and Villanueva, Laura
Published: 2024
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7. Nuclear charge radii of silicon isotopes

Author: König, Kristian, Berengut, Julian C., Borschevsky, Anastasia, Brinson, Alex, Brown, B. Alex, Dockery, Adam, Elhatisari, Serdar, Eliav, Ephraim, Ruiz, Ronald F. Garcia, Holt, Jason D., Hu, Bai-Shan, Karthein, Jonas, Lee, Dean, Ma, Yuan-Zhuo, Meißner, Ulf-G., Minamisono, Kei, Oleynichenko, Alexander V., Pineda, Skyy, Prosnyak, Sergey D., Reitsma, Marten L., Skripnikov, Leonid V., Vernon, Adam, and Zaitsevski, Andrei
Subjects: Nuclear Experiment, Nuclear Theory
Abstract: The nuclear charge radius of $^{32}$Si was determined using collinear laser spectroscopy. The experimental result was confronted with ab initio nuclear lattice effective field theory, valence-space in-medium similarity renormalization group, and mean field calculations, highlighting important achievements and challenges of modern many-body methods. The charge radius of $^{32}$Si completes the radii of the mirror pair $^{32}$Ar - $^{32}$Si, whose difference was correlated to the slope $L$ of the symmetry energy in the nuclear equation of state. Our result suggests $L \leq 60$\,MeV, which agrees with complementary observables.
Published: 2023

8. Feasibility of Indirect Treatment Comparisons Between Niraparib Plus Abiraterone Acetate and Other First-Line Poly ADP-Ribose Polymerase Inhibitor Treatment Regimens for Patients with BRCA1/2 Mutation-Positive Metastatic Castration-Resistant Prostate Cancer

Author: De Santis, Maria, Breijo, Sara Martínez, Robinson, Paul, Capone, Camille, Pascoe, Katie, Van Sanden, Suzy, Hashim, Mahmoud, Trevisan, Marco, Daly, Caitlin, Reitsma, Friso, van Beekhuizen, Sophie, Ruan, Haoyao, Heeg, Bart, and Verzoni, Elena
Published: 2024
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9. Perceptions of the impact of individual allergic rhinitis symptoms: A survey of ARIA clinical experts

Author: Sara Gil-Mata, MD, Tatiana Teixeira, MD, Anna Bedbrook, BSc, Jean Bousquet, PhD, Bernardo Sousa-Pinto, PhD, Rafael José Vieira, MD, Julijana Asllani, Habib Douagui, Estrella Asayag, Castro Maria Elizabeth, Carlos D. Crisci, René Maximiliano Gomez, Juan Carlos Ivancevich, Edgardo Jares, Jorge Fernando Máspero, Pablo Moreno, Hugo Eduardo Neffen, Mario Emilio Zernotti, Sinthia Bosnic-Anticevich, Kristin Chahhoud Carson, Biljana Cvetkovski, Janet M. Davies, Vicky Kritikos, Robyn O'Hehir, Brian Oliver, House Rachel Tan, Jessica Tattersall, Celia Zubrinich, Werner Aberer, Verena Niederberger-Leppin, Isabella Pali-Schöll, Virginie Doyen, Didier Ebo, Renaud Louis, Philippe Rombaux, Sophie Scheire, Kazi Bennoor, Bruno A. Barreto, Paulo Camargos, Herberto Jose Chong-Neto, Alvaro A. Cruz, Jane da Silva, Guidacci Marta, José Angelo Rizzo, Nelson Rosario Filho, Sarquis Serpa Faradiba, Dirceu Solé, Marilyn Urrutia-Pereira, George Christoff, Mandazhieva-Pepelanova Mariana, Odjakova Cvetanka, Todor A. Popov, Dilyana Vicheva, do Ceu Teixeira Maria, Jacques Bouchard, Jan Brozek, Derek K. Chu, Judah Denburg, Thomas Eiwegger, Paul K. Keith, Teresa To, Susan Waserman, Nancy Abusada, Emilio Alvarez Cuesta, Mario A. Calvo-Gil, Maria Antonieta Guzmán, Tamara Pérez Gomez, Wing Kin Wong Gary, Luo Zhang, Luis Caraballo, Alfonso Cepeda Sarabia, Dieudonné Nyembue, Manuel Soto-Martinez, Neven Miculinic, Davor Plavec, Constantinos Pitsios, Panayiotis Yiallouros, Petr Panzner, Milan Sova, Martina Vachova, Carsten Bindslev-Jensen, Ronald Dahl, Hans-Jorgen Malling, Lars Münter, Lars K. Poulsen, Suppli Ulrik Charlotte, Line Kring Tannert, Bassam Mahboub, Laila Salameh, Ivan Cherrez-Ojeda, de Guevara Karla Robles, Rasha Hassan El-Owaidy, Zeinab A. El-Sayed, Shereen Saad El-Sayed, Elham Hossny, Badr Eldin Mostafa, Kaja Julge, Nils Eric Billo, Patrik Eklund, Marina Erhola, Tari Haahtela, Jussi Karjalainen, Mika Makela, Sanna Toppila-Salmi, Erkka Valovirta, Tuula Vasankari, Isabella Annesi-Maesano, Isabelle Bossé, Melisande Bourgoin-Heck, Denis Charpin, André Coste, Frédéric de Blay, Philippe Devillier, Alain Didier, Anh Tuan Dinh-Xuan, Jean-François Fontaine, Jocelyne Just, Rachel Nadif, Nhân Pham-Thi, Bernard Pigearias, Nicolas Roche, Van Ganse Eric, Ekaterine Chkhartishvili, Amiran Gamkrelidze, Maia Gotua, Sven Becker, Karl-Christian Bergmann, Thomas Bieber, Randolf Brehler, Roland Buhl, Adam M. Chaker, Ulf Darsow, Eckard Hamelmann, Joachim Heinrich, Thomas Keil, Ludger Klimek, Pavel Kolkhir, Susanne Lau, Marcus Maurer, Ralph Mösges, Angelos Neou, Oliver Pfaar, Johannes Ring, Martin Wagenmann, Torsten Zuberbier, Aiste Ramanauskaite, Anja Lingnau, Demetrios Christou, Sophia Neisinger, Xenophon Aggelidis, Jannis Constantinidis, Maria Dimou, Christos Grigoreas, Trisevgeni Kapsali, Michael Katotomichelakis, Stelios Loukides, Michael Makris, Emmanouil Manousakis, Nikolaos Mikos, Aris Pagkalos, Nikolaos G. Papadopoulos, Vasileios Papanikolaou, Giannis Paraskevopoulos, Konstantina Piskou, Emmanuel Prokopakis, Fotios Psarros, Konstantinos Samitas, Sofia Stamataki, Evangelia Stefanaki Lina, Ekaterini Syrigou, Ioanna Tsiligianni, Mina Vallianatou, Dimitrios Vourdas, Paraskevi Xepapadaki, Aspasia Karavelia, Fanny Wai San Ko, Gary Wong, Andor Hirschberg, Helga Kraxner, Kristof Nekam, Stephen Lane, Menachem Rottem, Cristina Artesani Maria, Simona Barbaglia, Bianca Beghé, Beatrice Bilo Maria, Attilio Boner, Matteo Bonini, Sergio Bonini, Fulvio Braido, Luisa Brussino, G Walter Canonica, Lorenzo Cecchi, Giorgio Ciprandi, Enrico Compalati, Gennaro D'Amato, Giulia De Feo, Stefano Del Giacco, Alessandro Fiocchi, Enrico Heffler, Carlo Lombardi, Riccardo Monti, Antonella Muraro, Eustachio Nettis, Stefania Nicola, Giovanni Passalacqua, Vincenzo Patella, Francesca Puggioni, Giovanni Rolla, Antonino Romano, Nicola Scichilone, Massimo Triggiani, Teresa Ventura Maria, Giovanni Viegi, Cristina Boccabella, Mattia Giovannini, Anand Mahesh Padukudru, Tomohisa Iinuma, Ken Ohta, Yoshitaka Okamoto, Kimihiro Okubo, Ruby Pawankar, Daiju Sakurai, Maho Suzukawa, Masao Yamaguchi, Zhanat Ispayeva, Yoon-Seok Chang, Hae-Sim Park, Mona Al-Ahmad, Ieva Cirule, Ineta Grisle, Carla Irani, Philip Rouadi, Fares Zaitoun, Ruta Dubakiene, Regina Emuzyte, Violeta Kvedariene, Brigita Gradauskiene, Arunas Valiulis, Markus Ollert, Farah Hannachi, Dejan Dokic, Amir Hamzah Abdul Latiff, Baharudin Abdullah, S.P. Palaniappan, Kent Woo, Stephen Montefort, Martín Bedolla Barajas, María del Carmen Costa Domínguez, Jesús Guillermo Espinoza Contreras, Jose Miguel Fuentes Pèrez, José Luis Gálvez Romero, María de la Luz Hortensia García Cruz, Sandra González Diaz, Yunuen Rocío Huerta Villalobos, Désiree E. Larenas-Linnemann, Jorge Agustin Luna-Pech, Juan José Matta Campos, Daniela Rivero Yeverino, Mónica Rodríguez González, Eréndira Rodríguez Zagal, Battur Lkhagvaa, Sandra Mavale-Manuel, Abrantes Nunes Elizabete, Niels Chavannes, Wytske J. Fokkens, Gerard Koppelman, Anke-Hilse Maitland-van der Zee, Sietze Reitsma, Ramanathan Chandrasekharan, Osman Yusuf, Maria Susana Repka-Ramirez, Juan Carlos Sisul, José E. Gereda, Marysia T. Recto, Slawomir Bialek, Artur Bialoszewski, Marta Chelminska, Radoslaw Gawlik, Ewa Jassem, Marek Jutel, Piotr Kuna, Maciej Kupczyk, Marcin Moniuszko, Marek Niedoszytko, Filip Raciborski, Jan Romantowski, Boleslaw Samolinski, Krzysztof Specjalski, Pedro Carreiro Martins, Jaime Correia de Sousa, Elisio Costa, Joao A. Fonseca, Olga Lourenço, Mario Morais-Almeida, Margarida Pereira Ana, Frederico Regateiro, Carlos Robalo Cordeiro, Jose Rosado Pinto, Bernardo Sousa-Pinto, Luis Taborda Barata, Ana Maria Todo-Bom, José Vieira Rafael, Daniela Carvalho, Maryam Ali Al-Nesf, Ioana Agache, Camelia Berghea Elena, Roxana Bumbacea, Diana Deleanu, Florin Mihaltan, Carmen Panaitescu Bunu, Musa Khaitov, Leyla Namazova-Baranova, Elena Vishneva, Ali Alshaikh Nada, Sanja Dimic-Janjic, Branislava Milenkovic, De Yun Wang, Martin Hrubiško, Natalija Edelbaher, Maja Jošt, Peter Kopac, Mitja Košnik, Nika Lalek, Antonija Poplas Susic, Irma Rozman Sinur, Tanja Soklic Košak, Nadja Triller, Katja Triller, Jure Urbancic, Mihaela Zidarn, Michael Levin, Paul Potter, Heather Zar, Isam Alobid, Aram Anto, Joan Bartra, Irina Bobolea, Paloma Campo, Vicky Cardona, Maria Carriazo Ana, José Antonio Castillo Vizuete, Tomas Chivato, Ignacio Jesus Davila Gonzalez, Joaquim Mullol, Antonio Nieto Garcia, César Picado, Santiago Quirce, Joaquin Sastre, Leticia de las Vecillas, Mikael Benson, Inger Kull, Marianne van Hage, Magnus Wickman, Nikolai Khaltaev, Yousser Mohammad, Pongsakorn Tantilipikorn, Pakit Vichyanond, Cemal Cingi, Bilun Gemicioglu, Ozlem Goksel, Omer Kalayci, Ali Fuat Kalyoncu, Cem Meço, Koyuncu Ilgim Vardaloglu, Arzu Yorgancioglu, Deniz Eyice Karabacak, Bruce Kirenga, Ian Michael Adcock, Hasan S. Arshad, Mike Bewick, Christine Bond, Christopher Brightling, Andrew Bush, Moïses Calderon, Kian Fan Chung, Adnan Custovic, Ratko Djukanovic, Stephen Durham, John Farrell, David Halpin, Michael Hyland, Sebastian Johnston, Brian Lipworth, Alla Nakonechna, David Price, Graham Roberts, Dermot Ryan, Jürgen Schwarze, Aziz Sheikh, Mike Shields, Samantha Walker, Sian Williams, Igor Kaidashev, Andrii Igorevich Kurchenko, Vladyslav Tsaryk, David Bernstein, Jonathan A. Bernstein, Thomas B. Casale, Sharon Chinthrajah, Mark Dykewicz, Gailen D. Marshall, Eli O. Meltzer, Robert M. Naclerio, Alkis Togias, Elina Toskala, Dana Wallace, Dennis M. Williams, Barbara Yawn, Fernan Caballero-Fonseca, Lan Le Thi Tuyet, and Tran Thien Quan Vu
Subjects: Allergic rhinitis, Survey, Professional-patient relation, Immunologic diseases. Allergy, RC581-607
Abstract: Background: Allergic rhinitis (AR) is a highly prevalent disease. We aimed to assess the symptoms that physicians who see patients with AR perceive as the most bothersome in their patients. Methods: We performed a cross-sectional study based on an online questionnaire sent to all members of the Allergic Rhinitis and its Impact on Asthma (ARIA) initiative. The survey included questions on the physicians' perceptions of patients’ AR symptoms as well as of their own AR symptoms. Results: Among 401 respondents, 155 (38.7%) reported having AR. ARIA members reported nasal symptoms to be the most frequent (89.7%) and bothersome (80.0%) symptoms experienced by themselves. Likewise, nasal symptoms were reported by ARIA members as the most frequent (94.8% in members with AR vs 96.0% in members without AR) and bothersome (57.0% in members with AR vs 67.9% in members without AR) in their patients. We found a significant association (p = 0.001) between physicians’ own symptoms and those perceived as the most bothersome in their patients. Conclusion: Physicians perceive nasal symptoms to be the most frequent and the most bothersome symptoms in AR patients. The physicians' personal experiences with AR may influence their perception of patients’ symptoms.
Published: 2024
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10. Psychotrauma binnen letselschade

Author: van Zitteren, Moniek, Nelemans, Ton, and Reitsma, Angelique
Published: 2024
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11. Clinical Validation of Multiparametric Ultrasound for Detecting Clinically Significant Prostate Cancer Using Computer-Aided Diagnosis: A Direct Comparison with the Magnetic Resonance Imaging Pathway

Author: Daniel L. van den Kroonenberg, Auke Jager, Anna Garrido-Utrilla, Johannes B. Reitsma, Arnoud W. Postema, Harrie P. Beerlage, and Jorg R. Oddens
Subjects: Prostate cancer, Magnetic resonance imaging, Ultrasound, Artificial intelligence, Computer-aided diagnosis, Prostate biopsy, Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: We present the protocol for a study testing the hypothesis that a computer-aided diagnosis (CAD) system for three-dimensional multiparametric ultrasound (3D mpUS) is noninferior to magnetic resonance imaging (MRI) in guiding prostate biopsies for detection of clinically significant prostate cancer (csPCa). The prospective study has a fully paired design for assessment of diagnostic accuracy and is registered on ClinicalTrials.gov as NCT06281769. A total of 438 biopsy-naïve men scheduled for prostate MRI evaluation because of an abnormal digital rectal examination and/or elevated serum prostate-specific antigen will be included. All patients will undergo both MRI (multiparametric or biparametric) and 3D mpUS with CAD (PCaVision). Suspicious lesions will be independently identified using each imaging technique. MRI targeted biopsy (TBx) and/or PCaVision TBx will be performed if suspicious lesions are identified on imaging. When both PCaVision and MRI identify lesions in an individual patient, the TBx order for this patient will be randomized. Three TBx samples per lesion will be taken for a maximum of two lesions per modality. The primary objective is the detection rate for csPCa (International Society of Urological Pathology grade group [GG] ≥2) with the PCaVision versus the MRI TBx pathway. The noninferiority margin for the absolute difference in detection rates is set at a difference of 5%. Secondary outcomes are the proportion of men in whom TBx could have been safely omitted in each pathway. Additional diagnostic accuracy analyses will be performed for different definitions of PCa (GG ≥3; GG ≥2 with cribriform growth and/or intraductal carcinoma; and GG 1). The frequency of insufficient image quality for the two pathways will also be assessed. Lastly, we will determine the diagnostic performance for csPCa detection at various 3D mpUS image quality thresholds for PCaVision.
Published: 2024
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12. Prolonged grief and posttraumatic stress in parents who lost a child in a road traffic accident: A latent class analysis

Author: I. van Dijk, P.A. Boelen, J. de Keijser, L. Reitsma, and L.I.M. Lenferink
Subjects: Prolonged grief, Posttraumatic stress, Loss, Bereaved parents, Road traffic accident, Self-directed anger, Mental healing, RZ400-408
Abstract: Background: The traumatic loss of a child in a road traffic accident (RTA) can lead to mental health issues in parents, such as symptoms of prolonged grief (PG) and posttraumatic stress (PTS). Latent class analysis (LCA) provides insights into different responses to such losses. Methods: Using LCA, 148 parents that were bereaved at least twelve months earlier, were categorized into latent classes based on similar response patterns. Associations between class membership and sociodemographic and loss-related variables and self-directed anger were examined. Results: Two symptom patterns emerged: a 'High PG/Moderate PTS' pattern (73.2 %) and a 'Moderate-High PG/Low PTS' pattern (26.8 %). Mothers and those with more self-directed anger were more likely to present with the first symptom pattern. Limitations: Inclusion of parents undergoing therapy for clinically relevant symptoms, small sample size, no differentiation between parents of minor and adult children, and including only four PTS symptoms are limitations that may have influenced the identified symptom patterns. Conclusions: Parents who lost a child in a RTA seem at risk for developing psychological symptoms, with PG being more predominant than PTS. The study highlights the possible value of addressing modifiable factors such as self-directed anger in therapeutic interventions for PG and PTS after traumatic loss of a child.
Published: 2025
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13. Computing torsion subgroups of Jacobians of hyperelliptic curves of genus 3

Author: Müller, J. Steffen and Reitsma, Berno
Subjects: Mathematics - Number Theory, Mathematics - Algebraic Geometry, 11G10, 11G30, 14H40, 14K15
Abstract: We introduce an algorithm to compute the rational torsion subgroup of the Jacobian of a hyperelliptic curve of genus 3 over the rationals. We apply a Magma implementation of our algorithm to a database of curves with low discriminant due to Sutherland as well as a list of curves with small coefficients. In the process, we find several torsion structures not previously described in the literature. The algorithm is a generalisation of an algorithm for genus 2 due to Stoll, which we extend to abelian varieties satisfying certain conditions. The idea is to compute p-adic torsion lifts of points over finite fields using the Kummer variety and to check whether they are rational using heights. Both have been made explicit for Jacobians of hyperelliptic curves of genus 3 by Stoll. This article is partially based on the second-named author's Master thesis., Comment: Fixed typos; to appear in Research in Number Theory
Published: 2022

14. Under pressure: learning-based analog gauge reading in the wild.

Author: Maurits Reitsma, Julian Keller, Kenneth Blomqvist, and Roland Siegwart
Published: 2024
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15. Five Research Strategies for Increasing Rigor in Action Research

Author: Haug, Anders, Reitsma, Ewout, Haug, Kristian Bloch, Freytag, Per Vagn, editor, Young, Louise, editor, and Evald, Majbritt Rostgaard, editor
Published: 2024
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16. Evaluation of Surgical Treatments

Author: Fokkens, Wytske J., Drubbel, Joekio J., Reitsma, Sietze, Lund, Valerie J., Önerci Celebi, Özlem, editor, and Önerci, T. Metin, editor
Published: 2024
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17. Spatial Variation Sequences for Remote Sensing Applications with Small Sample Sizes

Author: Jeune, Hayden, Pechan, Niklas, Reitsma, Sharn-Konet, Kempa-Liehr, Andreas W., Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Yan, Wei Qi, editor, Nguyen, Minh, editor, Nand, Parma, editor, and Li, Xuejun, editor
Published: 2024
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18. Supply Chain Strategizing in New Product Development : An Interplay of Practitioners, Activities, and Practices

Author: Reitsma, Ewout, Hilletofth, Per, and Sarkis, Joseph, editor
Published: 2024
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19. Real-world effectiveness of dupilumab in a European cohort of chronic rhinosinusitis with nasal polyps (CHRINOSOR)

Author: Alobid, Isam, Andrianakis, Alexandros, Hellings, Peter W., Hopkins, Claire, Hox, Valérie, Kjeldsen, Anette, Laulajainen-Hongisto, Anu, Lund, Valerie, Van Gerven, Laura, Seys, Sven F., Schneider, Sven, de Kinderen, Joost, Reitsma, Sietze, Cavaliere, Carlo, Tomazic, Peter-Valentin, Morgenstern, Christina, Mortuaire, Geoffrey, Wagenmann, Martin, Bettio, Giulia, Ciofalo, Andrea, Diamant, Zuzana, Eckl-Dorna, Julia, Fokkens, Wytske J., Holzmeister, Clemens, Mariën, Gert, Masieri, Simonetta, Otten, Josje, Scheckenbach, Kathrin, Tu, Aldine, and Bachert, Claus
Published: 2025
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20. Methodological quality assessment tools for diagnosis and prognosis research: overview and guidance

Author: Kaul, Tabea, Kellerhuis, Bas E., Damen, Johanna A.A., Schuit, Ewoud, Jenniskens, Kevin, van Smeden, Maarten, Reitsma, Johannes B., Hooft, Lotty, Moons, Karel G.M., and Yang, Bada
Published: 2025
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21. Functional characterization of a nanobody-based glycoprotein VI-specific platelet agonist

Author: Minka Zivkovic, Elisabeth Pols - van Veen, Vossa van der Vegte, Silvie A.E. Sebastian, Annick S. de Moor, Suzanne J.A. Korporaal, Roger E.G. Schutgens, Rolf T. Urbanus, Erik Beckers, Michiel Coppens, Jeroen Eikenboom, Louise Hooimeijer, Gerard Jansen, Roger Schutgens, Rolf Urbanus, Emile van den Akker, Wala Al Arashi, Ryanne Arisz, Lieke Baas, Ruben Bierings, Maartje van den Biggelaar, Johan Boender, Anske van der Bom, Mettine Bos, Martijn Brands, Annelien Bredenoord, Laura Bukkems, Lex Burdorf, Jessica Del Castillo Alferez, Michael Cloesmeijer, Marjon Cnossen, Mariëtte Driessens, Karin Fijnvandraat, Kathelijn Fischer, Geertje Goedhart, Tine Goedhart, Samantha Gouw, Rieke van der Graaf, Masja de Haas, Lotte Haverman, Jan Hazelzet, Shannon van Hoorn, Elise Huisman, Nathalie Jansen, Alexander Janssen, Sean de Jong, Sjoerd Koopman, Marieke Kruip, Sebastiaan Laan, Frank Leebeek, Nikki van Leeuwen, Hester Lingsma, Moniek de Maat, Ron Mathôt, Felix van der Meer, Karina Meijer, Sander Meijer, Stephan Meijer, Iris van Moort, Caroline Mussert, Hans Kristian Ploos van Amstel, Suzanne Polinder, Diaz Prameyllawati, Simone Reitsma, Eliza Roest, Lorenzo Romano, Saskia Schols, Carin Uyl, Jan Voorberg, and Huan Zhang
Subjects: diagnostic tests, glycoprotein, nanobodies, platelet activation, platelet function tests, Diseases of the blood and blood-forming organs, RC633-647.5
Abstract: Background: Glycoprotein (GP)VI is a platelet-specific collagen receptor required for platelet activation during hemostasis. Platelet reactivity toward collagen is routinely assessed during diagnostic workup of platelet disorders. GPVI can be activated by inducing receptor clustering with suspensions of fibrillar collagen or synthetic cross-linked collagen-related peptide (CRP-XL). However, these suspensions are poorly standardized or difficult to produce. Nanobodies are small recombinant camelid-derived heavy-chain antibody variable regions. They are highly stable, specific, and ideal candidates for developing a stable GPVI agonist for diagnostic assays. Objectives: Develop a stable nanobody-based GPVI agonist. Methods: Nanobody D2 (NbD2) was produced as dimers and purified. Tetramers were generated via C-terminal fusion of dimers with click chemistry. Nanobody constructs were functionally characterized with light transmission aggregometry (LTA) in platelet-rich plasma and whole blood flow cytometry. Diagnostic performance was assessed in patients with inherited platelet function disorders with LTA and flow cytometry. Results: NbD2 was specific for human platelet GPVI. Dimers did not result in platelet activation in LTA or flow cytometry settings and fully inhibited CRP-XL-induced P-selectin expression and fibrinogen binding in whole blood and attenuated collagen-induced platelet aggregation in platelet-rich plasma. However, NbD2 tetramers caused full platelet aggregation, as well as P-selectin expression and fibrinogen binding. NbD2 tetramers were able to discriminate between inherited platelet function disorder patients and healthy controls based on fibrinogen binding, similar to CRP-XL. Conclusion: Nanobody tetramers to GPVI induce platelet activation and can be used to assess the GPVI pathway in diagnostic assays.
Published: 2024
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22. The role of foreign language anxiety and task complexity on fluency in German learners of Dutch

Author: Foekje Reitsma and Esther Ruigendijk
Subjects: fluency, foreign language anxiety, task complexity, proficiency, Philology. Linguistics, P1-1091
Abstract: This study investigated which aspects of fluency are related to foreign language anxiety and proficiency, and how this interacts with task complexity during a non-exam situation. Sixty-one low-intermediate German learners of Dutch completed a foreign language anxiety questionnaire, a proficiency test and two speech production tasks. Correlational analyses showed that anxiety was negatively related to number of mid-clause pauses in a complex task. Proficiency was positively related to numerous speed and breakdown fluency measures in a simple task. Mixed-effects models demonstrated that proficiency predicted two fluency measures. Task type positively predicted speed fluency. Anxiety was not a significant predictor of any fluency measure, which may be related to participants’ relatively low anxiety level. This finding suggests that anxiety may not have a strong influence during speaking tasks that are not part of formal assessments.
Published: 2024
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23. MONITORING FIBRINOLYSIS WITH GLOBAL ASSAYS TO DETECT HYPER AND HYPOFIBRINOLYSIS PHENOTYPES

Author: SAL Montalvao, Y Sang, S Reitsma, L Arzenares, MC Fernandes, BM Martinelli, LQ Silva, EV Paula, JM Annichino-Bizzacchi, and AS Wolberg
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Abstract: Introduction: The fibrinolytic system is an important component of hemostasis that acts as a balance of blood coagulation to protect the vasculature from damaging thrombus formation. Monitoring fibrinolysis has been considered an emerging science, and recent studies show that fibrinolysis aids in the assessment of subgroups of critically ill patients at risk of bleeding and thrombotic complications. In this context, global tests to identify fibrinolytic potential have been developed, and knowledge about the performance of these tests is still limited. The aim of this study was to evaluate the performance of global fibrinolysis assays to detect hypo- and hyperfibrinolysis phenotypes. Method: In this study, samples from Healthy Individuals (HI), patients with hematologic Cancer (CA) and Venous Thrombosis (VTE), were obtained from the UNICAMP Hemocentro biobank. The methods assessed were: (1) Turbidimetric tPA-induced clot lysis time assay (tPA-CLT), (2) Turbidimetric tPA-induced clot lysis time assay with thrombomolulin (tPA-CLT-TM), (3) Plasmin generation test (PG). Demographic data, biochemical and coagulation tests, and clinical outcomes were collected. The study was part of the ISTH Reach the World Fellowship Program, in collaboration with the UNC Blood Research Center, Chapel Hill NC USA. Results: Plasmas from 107 individuals were evaluated in parallel: 30 CA, 25 VTE, and 52 HI matched by sex and age. The median age was 53 (21‒71), 48 (25‒72), 43 (19‒66), the male to female ratio was 15:15, 17:8, 34:18 for CA, VTE and HI, respectively. For tPA-CLT, only the median Onset-Time (min) was found to be higher for VTE when compared to HI, 6.0 and 5.3 (p < 0.05). Interestingly, the tPA-CLT presented 4/6 parameters with higher median for CA compared to HI: (1) Time to peak (min) 10.67 and 9.23 (p > 0.005); (2) VMax (mOD/Min) 526.80 and 386.40 (p < 0.0001); (3) Turbidity change 0.6851 and 0.5000 (p < 0.001); (4) AUC 4.085 and 3.060 (p < 0.05). The tPA-CLT-TM test showed the same pattern of results as the tPA-CLT test for VTE and CA. However, for CA the results showed even more significant differences in the same parameters, with the addition of Lysis Time (min) 26.84 and 19.33 (p < 0.001). PG presented 2/5 parameters with lower median for VTE compared to HI: (1) Onset-Time (min) 4.465 and 4.760 (p < 0.05) and (2) VMax (mOD/Min) 22.25 and 23.26 (p < 0.05). To PG, CA presented 3/5 parameters with lower median compared to HI: (1) VMax (mOD/Min) 20.58 and 23.26 (p < 0.001); (2) Peak (nM) 54.40 and 60.26 (p < 0.05); EPP (nM.min) 337.1 and 479.5 (p < 0.001). CA patients showed an association between tPA-CLT parameters and creatinine (p < 0.001) and eGRF was assessed. VTE patients showed an association of tPA-CLT parameters with LDL, Triglycerides (p < 0.05). Thrombin generation test and D-dimer were evaluated. Discussions and conclusions: The performance of global fibrinolysis tests was different between VTE, CA and HI. The tPA-CLT and tPA-CLT-TM assays proved to be sensitive for CA patients, suggesting faster, larger and heavier fibrin formation. In a more specific evaluation, CA showed lower plasmin generation. The tPA-CLT with the addition of thrombomodulin, as activator, had not yet been explored and was shown to favor the sensitivity of the test. The different performance of these tests could help identify hypo- and hyperfibrinolysis phenotypes, and thus contribute to the assessment of subgroups of critically ill patients at risk of bleeding and thrombotic complications.
Published: 2024
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24. Multi-modal analysis reveals tumor and immune features distinguishing EBV-positive and EBV-negative post-transplant lymphoproliferative disorders

Author: Toh, Jiaying, Reitsma, Andrea J., Tajima, Tetsuya, Younes, Sheren F., Ezeiruaku, Chimere, Jenkins, Kayla C., Peña, Josselyn K., Zhao, Shuchun, Wang, Xi, Lee, Esmond Y.Z., Glass, Marla C., Kalesinskas, Laurynas, Ganesan, Ananthakrishnan, Liang, Irene, Pai, Joy A., Harden, James T., Vallania, Francesco, Vizcarra, Edward A., Bhagat, Govind, Craig, Fiona E., Swerdlow, Steven H., Morscio, Julie, Dierickx, Daan, Tousseyn, Thomas, Satpathy, Ansuman T., Krams, Sheri M., Natkunam, Yasodha, Khatri, Purvesh, and Martinez, Olivia M.
Published: 2024
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25. Identifying challenges of the US domestic seaweed aquaculture industry

Author: Kotowicz, Dawn M., Concepcion, Anoushka, Bradt, Gabriella, Chadsey, Meg, Clemetson, Antionette, Good, Melissa, Reitsma, Joshua, and Robidoux, Jaclyn
Published: 2024
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26. Host associations of Campylobacter jejuni and Campylobacter coli isolates carrying the L-fucose or d-glucose utilization cluster

Author: Middendorf, Pjotr S., Zomer, Aldert L., Bergval, Indra L., Jacobs-Reitsma, Wilma F., den Besten, Heidy M.W., and Abee, Tjakko
Published: 2024
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27. The effectiveness of Function Focused Care among patients acutely admitted to hospital: A stepped wedge cluster trial

Author: Kok, Selma, Schoonhoven, Lisette, Vernooij, Lisette M., Reitsma, Johannes B., Verstraten, Carolien, Metzelthin, Silke F., Bleijenberg, Nienke, and de Man-van Ginkel, Janneke M.
Published: 2024
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28. Hypertension care cascades and reducing inequities in cardiovascular disease in low- and middle-income countries

Author: Stein, Dorit Talia, Reitsma, Marissa B., Geldsetzer, Pascal, Agoudavi, Kokou, Aryal, Krishna Kumar, Bahendeka, Silver, Brant, Luisa C. C., Farzadfar, Farshad, Gurung, Mongal Singh, Guwatudde, David, Houehanou, Yessito Corine Nadège, Malta, Deborah Carvalho, Martins, João Soares, Saeedi Moghaddam, Sahar, Mwangi, Kibachio Joseph, Norov, Bolormaa, Sturua, Lela, Zhumadilov, Zhaxybay, Bärnighausen, Till, Davies, Justine I., Flood, David, Marcus, Maja E., Theilmann, Michaela, Vollmer, Sebastian, Manne-Goehler, Jennifer, Atun, Rifat, Sudharsanan, Nikkil, and Verguet, Stéphane
Published: 2024
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29. Consistent patterns of common species across tropical tree communities

Author: Cooper, Declan L. M., Lewis, Simon L., Sullivan, Martin J. P., Prado, Paulo I., ter Steege, Hans, Barbier, Nicolas, Slik, Ferry, Sonké, Bonaventure, Ewango, Corneille E. N., Adu-Bredu, Stephen, Affum-Baffoe, Kofi, de Aguiar, Daniel P. P., Ahuite Reategui, Manuel Augusto, Aiba, Shin-Ichiro, Albuquerque, Bianca Weiss, de Almeida Matos, Francisca Dionízia, Alonso, Alfonso, Amani, Christian A., do Amaral, Dário Dantas, do Amaral, Iêda Leão, Andrade, Ana, de Andrade Miranda, Ires Paula, Angoboy, Ilondea B., Araujo-Murakami, Alejandro, Arboleda, Nicolás Castaño, Arroyo, Luzmila, Ashton, Peter, Aymard C, Gerardo A., Baider, Cláudia, Baker, Timothy R., Balinga, Michael Philippe Bessike, Balslev, Henrik, Banin, Lindsay F., Bánki, Olaf S., Baraloto, Chris, Barbosa, Edelcilio Marques, Barbosa, Flávia Rodrigues, Barlow, Jos, Bastin, Jean-Francois, Beeckman, Hans, Begne, Serge, Bengone, Natacha Nssi, Berenguer, Erika, Berry, Nicholas, Bitariho, Robert, Boeckx, Pascal, Bogaert, Jan, Bonyoma, Bernard, Boundja, Patrick, Bourland, Nils, Boyemba Bosela, Faustin, Brambach, Fabian, Brienen, Roel, Burslem, David F. R. P., Camargo, José Luís, Campelo, Wegliane, Cano, Angela, Cárdenas, Sasha, Cárdenas López, Dairon, de Sá Carpanedo, Rainiellen, Carrero Márquez, Yrma Andreina, Carvalho, Fernanda Antunes, Casas, Luisa Fernanda, Castellanos, Hernán, Castilho, Carolina V., Cerón, Carlos, Chapman, Colin A., Chave, Jerome, Chhang, Phourin, Chutipong, Wanlop, Chuyong, George B., Cintra, Bruno Barçante Ladvocat, Clark, Connie J., Coelho de Souza, Fernanda, Comiskey, James A., Coomes, David A., Cornejo Valverde, Fernando, Correa, Diego F., Costa, Flávia R. C., Costa, Janaina Barbosa Pedrosa, Couteron, Pierre, Culmsee, Heike, Cuni-Sanchez, Aida, Dallmeier, Francisco, Damasco, Gabriel, Dauby, Gilles, Dávila, Nállarett, Dávila Doza, Hilda Paulette, De Alban, Jose Don T., de Assis, Rafael L., De Canniere, Charles, De Haulleville, Thales, de Jesus Veiga Carim, Marcelo, Demarchi, Layon O., Dexter, Kyle G., Di Fiore, Anthony, Din, Hazimah Haji Mohammad, Disney, Mathias I., Djiofack, Brice Yannick, Djuikouo, Marie-Noël K., Do, Tran Van, Doucet, Jean-Louis, Draper, Freddie C., Droissart, Vincent, Duivenvoorden, Joost F., Engel, Julien, Estienne, Vittoria, Farfan-Rios, William, Fauset, Sophie, Feeley, Kenneth J., Feitosa, Yuri Oliveira, Feldpausch, Ted R., Ferreira, Cid, Ferreira, Joice, Ferreira, Leandro Valle, Fletcher, Christine D., Flores, Bernardo Monteiro, Fofanah, Alusine, Foli, Ernest G., Fonty, Émile, Fredriksson, Gabriella M., Fuentes, Alfredo, Galbraith, David, Gallardo Gonzales, George Pepe, Garcia-Cabrera, Karina, García-Villacorta, Roosevelt, Gomes, Vitor H. F., Gómez, Ricardo Zárate, Gonzales, Therany, Gribel, Rogerio, Guedes, Marcelino Carneiro, Guevara, Juan Ernesto, Hakeem, Khalid Rehman, Hall, Jefferson S., Hamer, Keith C., Hamilton, Alan C., Harris, David J., Harrison, Rhett D., Hart, Terese B., Hector, Andy, Henkel, Terry W., Herbohn, John, Hockemba, Mireille B. N., Hoffman, Bruce, Holmgren, Milena, Honorio Coronado, Euridice N., Huamantupa-Chuquimaco, Isau, Hubau, Wannes, Imai, Nobuo, Irume, Mariana Victória, Jansen, Patrick A., Jeffery, Kathryn J., Jimenez, Eliana M., Jucker, Tommaso, Junqueira, André Braga, Kalamandeen, Michelle, Kamdem, Narcisse G., Kartawinata, Kuswata, Kasongo Yakusu, Emmanuel, Katembo, John M., Kearsley, Elizabeth, Kenfack, David, Kessler, Michael, Khaing, Thiri Toe, Killeen, Timothy J., Kitayama, Kanehiro, Klitgaard, Bente, Labrière, Nicolas, Laumonier, Yves, Laurance, Susan G. W., Laurance, William F., Laurent, Félix, Le, Tinh Cong, Le, Trai Trong, Leal, Miguel E., Leão de Moraes Novo, Evlyn Márcia, Levesley, Aurora, Libalah, Moses B., Licona, Juan Carlos, Lima Filho, Diógenes de Andrade, Lindsell, Jeremy A., Lopes, Aline, Lopes, Maria Aparecida, Lovett, Jon C., Lowe, Richard, Lozada, José Rafael, Lu, Xinghui, Luambua, Nestor K., Luize, Bruno Garcia, Maas, Paul, Magalhães, José Leonardo Lima, Magnusson, William E., Mahayani, Ni Putu Diana, Makana, Jean-Remy, Malhi, Yadvinder, Maniguaje Rincón, Lorena, Mansor, Asyraf, Manzatto, Angelo Gilberto, Marimon, Beatriz S., Marimon-Junior, Ben Hur, Marshall, Andrew R, Martins, Maria Pires, Mbayu, Faustin M., de Medeiros, Marcelo Brilhante, Mesones, Italo, Metali, Faizah, Mihindou, Vianet, Millet, Jerome, Milliken, William, Mogollón, Hugo F., Molino, Jean-François, Mohd. Said, Mohd. Nizam, Monteagudo Mendoza, Abel, Montero, Juan Carlos, Moore, Sam, Mostacedo, Bonifacio, Mozombite Pinto, Linder Felipe, Mukul, Sharif Ahmed, Munishi, Pantaleo K. T., Nagamasu, Hidetoshi, Nascimento, Henrique Eduardo Mendonça, Nascimento, Marcelo Trindade, Neill, David, Nilus, Reuben, Noronha, Janaína Costa, Nsenga, Laurent, Núñez Vargas, Percy, Ojo, Lucas, Oliveira, Alexandre A., de Oliveira, Edmar Almeida, Ondo, Fidèle Evouna, Palacios Cuenca, Walter, Pansini, Susamar, Pansonato, Marcelo Petratti, Paredes, Marcos Ríos, Paudel, Ekananda, Pauletto, Daniela, Pearson, Richard G., Pena, José Luis Marcelo, Pennington, R. Toby, Peres, Carlos A., Permana, Andrea, Petronelli, Pascal, Peñuela Mora, Maria Cristina, Phillips, Juan Fernando, Phillips, Oliver L., Pickavance, Georgia, Piedade, Maria Teresa Fernandez, Pitman, Nigel C. A., Ploton, Pierre, Popelier, Andreas, Poulsen, John R., Prieto, Adriana, Primack, Richard B., Priyadi, Hari, Qie, Lan, Quaresma, Adriano Costa, de Queiroz, Helder Lima, Ramirez-Angulo, Hirma, Ramos, José Ferreira, Reis, Neidiane Farias Costa, Reitsma, Jan, Revilla, Juan David Cardenas, Riutta, Terhi, Rivas-Torres, Gonzalo, Robiansyah, Iyan, Rocha, Maira, Rodrigues, Domingos de Jesus, Rodriguez-Ronderos, M. Elizabeth, Rovero, Francesco, Rozak, Andes H., Rudas, Agustín, Rutishauser, Ervan, Sabatier, Daniel, Sagang, Le Bienfaiteur, Sampaio, Adeilza Felipe, Samsoedin, Ismayadi, Satdichanh, Manichanh, Schietti, Juliana, Schöngart, Jochen, Scudeller, Veridiana Vizoni, Seuaturien, Naret, Sheil, Douglas, Sierra, Rodrigo, Silman, Miles R., Silva, Thiago Sanna Freire, da Silva Guimarães, José Renan, Simo-Droissart, Murielle, Simon, Marcelo Fragomeni, Sist, Plinio, Sousa, Thaiane R., de Sousa Farias, Emanuelle, de Souza Coelho, Luiz, Spracklen, Dominick V., Stas, Suzanne M., Steinmetz, Robert, Stevenson, Pablo R., Stropp, Juliana, Sukri, Rahayu S., Sunderland, Terry C. H., Suzuki, Eizi, Swaine, Michael D., Tang, Jianwei, Taplin, James, Taylor, David M., Tello, J. Sebastián, Terborgh, John, Texier, Nicolas, Theilade, Ida, Thomas, Duncan W., Thomas, Raquel, Thomas, Sean C., Tirado, Milton, Toirambe, Benjamin, de Toledo, José Julio, Tomlinson, Kyle W., Torres-Lezama, Armando, Tran, Hieu Dang, Tshibamba Mukendi, John, Tumaneng, Roven D., Umaña, Maria Natalia, Umunay, Peter M., Urrego Giraldo, Ligia Estela, Valderrama Sandoval, Elvis H., Valenzuela Gamarra, Luis, Van Andel, Tinde R., van de Bult, Martin, van de Pol, Jaqueline, van der Heijden, Geertje, Vasquez, Rodolfo, Vela, César I. A., Venticinque, Eduardo Martins, Verbeeck, Hans, Veridiano, Rizza Karen A., Vicentini, Alberto, Vieira, Ima Célia Guimarães, Vilanova Torre, Emilio, Villarroel, Daniel, Villa Zegarra, Boris Eduardo, Vleminckx, Jason, von Hildebrand, Patricio, Vos, Vincent Antoine, Vriesendorp, Corine, Webb, Edward L., White, Lee J. T., Wich, Serge, Wittmann, Florian, Zagt, Roderick, Zang, Runguo, Zartman, Charles Eugene, Zemagho, Lise, Zent, Egleé L., and Zent, Stanford
Published: 2024
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30. Alpha peak frequency-based Brainmarker-I as a method to stratify to pharmacotherapy and brain stimulation treatments in depression

Author: Voetterl, Helena T. S., Sack, Alexander T., Olbrich, Sebastian, Stuiver, Sven, Rouwhorst, Renee, Prentice, Amourie, Pizzagalli, Diego A., van der Vinne, Nikita, van Waarde, Jeroen A., Brunovsky, Martin, van Oostrom, Iris, Reitsma, Ben, Fekkes, Johan, van Dijk, Hanneke, and Arns, Martijn
Published: 2023
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31. Application of Mass Cytometry Platforms to Solid Organ Transplantation

Author: Zhang, Wenming, Sen, Ayantika, Pena, Josselyn K., Reitsma, Andrea, Alexander, Oliver C., Tajima, Tetsuya, Martinez, Olivia M., and Krams, Sheri M.
Published: 2024
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32. Plasmin generation analysis in patients with bleeding disorder of unknown cause

Author: Mehic, Dino, Reitsma, Stéphanie E., de Moreuil, Claire, Haslacher, Helmuth, Koeller, Maximilian C., de Laat, Bas, Ay, Cihan, Pabinger, Ingrid, Wolberg, Alisa S., and Gebhart, Johanna
Published: 2024
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33. Molecular Tumor Board of the University Medical Center Groningen (UMCG-MTB): outcome of patients with rare or complex mutational profiles receiving MTB-advised targeted therapy

Author: de Jager, V.D., Plomp, P., Paats, M.S., van Helvert, S., Elst, A.ter, van den Berg, A., Dubbink, H.J., van Geffen, W.H., Zhang, L., Hendriks, L.E.L., Hiltermann, T.J.N., Hiddinga, B.I., Hijmering-Kappelle, L.B.M., Jalving, M., Kluiver, J., Koopman, B., van Kruchten, M., van der Logt, E.M.J., Piet, B., van Putten, J., Reitsma, B.H., Rutgers, S.R., de Vries, M., Stigt, J.A., Groves, M.R., Timens, W., Willems, S.M., van Kempen, L.C., Schuuring, E., and van der Wekken, A.J.
Published: 2024
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34. Efficacy of Biologics in NSAID-ERD: United Airways From the Nose to the Bronchi

Author: Buchheit, Kathleen M., Vandewalle, Elke, Elzinga, Hester B.E., Reitsma, Sietze, Fokkens, Wytske, and Geveart, Phillippe
Published: 2024
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35. Fibrinolysis is impaired in patients with primary immune thrombocytopenia

Author: Schramm, Theresa, Rast, Jasmin, Mehic, Dino, Reitsma, Stéphanie E., de Moreuil, Claire, Fillitz, Michael, Quehenberger, Peter, de Laat, Bas, Wolberg, Alisa S., Ay, Cihan, Pabinger, Ingrid, and Gebhart, Johanna
Published: 2024
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36. Activation of the l-fucose utilization cluster in Campylobacter jejuni induces proteomic changes and enhances Caco-2 cell invasion and fibronectin binding

Author: Pjotr S. Middendorf, Lucas M. Wijnands, Sjef Boeren, Aldert L. Zomer, Wilma F. Jacobs-Reitsma, Heidy M.W. den Besten, and Tjakko Abee
Subjects: Pathogen, Survival, Secretion system, Lipooligosaccharides, Food safety, Science (General), Q1-390, Social sciences (General), H1-99
Abstract: Most Campylobacter jejuni isolates carry the fucose utilization cluster (Cj0480c-Cj0489) that supports the metabolism of l-fucose and d-arabinose. In this study we quantified l-fucose and d-arabinose metabolism and metabolite production, and the impact on Caco-2 cell interaction and binding to fibronectin, using C. jejuni NCTC11168 and the closely related human isolate C. jejuni strain 286. When cultured with l-fucose and d-arabinose, both isolates showed increased survival and production of acetate, pyruvate and succinate, and the respective signature metabolites lactate and glycolic acid, in line with an overall upregulation of l-fucose cluster proteins. In vitro Caco-2 cell studies and fibronectin-binding experiments showed a trend towards higher invasion and a significantly higher fibronectin binding efficacy of C. jejuni NCTC11168 cells grown with l-fucose and d-arabinose, while no significant differences were found with C. jejuni 286. Both fibronectin binding proteins, CadF and FlpA, were detected in the two isolates, but were not significantly differentially expressed in l-fucose or d-arabinose grown cells. Comparative proteomics analysis linked the C. jejuni NCTC11168 phenotypes uniquely to the more than 135-fold upregulated protein Cj0608, putative TolC-like component MacC, which, together with the detected Cj0606 and Cj0607 proteins, forms the tripartite secretion system MacABC with putative functions in antibiotic resistance, cell envelope stress response and virulence in Gram negative pathogenic bacteria. Further studies are required to elucidate the role of the MacABC system in C. jejuni cell surface structure modulation and virulence.
Published: 2024
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37. Minimally modified human blood coagulation factor X to bypass direct factor Xa inhibitors

Author: Schreuder, Mark, Jourdi, Georges, Veizaj, Dejvid, Poole, David A., III, Cheung, Ka Lei, Poenou, Géraldine, Verhoef, Daniël, Thomassen, Stella, Janssen, Laura F.H., Stepanian, Alain, Hackeng, Tilman M., Gaussem, Pascale, Reitsma, Pieter H., Geerke, Daan P., Siguret, Virginie, and Bos, Mettine H.A.
Published: 2024
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38. Outflows from the youngest stars are mostly molecular

Author: Ray, T. P., McCaughrean, M. J., Caratti o Garatti, A., Kavanagh, P. J., Justtanont, K., van Dishoeck, E. F., Reitsma, M., Beuther, H., Francis, L., Gieser, C., Klaassen, P., Perotti, G., Tychoniec, L., van Gelder, M., Colina, L., Greve, Th. R., Güdel, M., Henning, Th., Lagage, P. O., Östlin, G., Vandenbussche, B., Waelkens, C., and Wright, G.
Published: 2023
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39. Transcriptional and functional profiling identifies inflammation and endothelial-to-mesenchymal transition as potential drivers for phenotypic heterogeneity within a cohort of endothelial colony forming cells

Author: Brands, Martijn, Koopman, Sjoerd, Bukkems, Laura, Cloesmeijer, Michael, Janssen, Alexander, Fijnvandraat, Karin, Gouw, Samantha, Mathôt, Ron, Haverman, Lotte, van den Akker, Emile, van den Biggelaar, Maartje, de Haas, Masja, Meijer, Sander, Voorberg, Jan, Del Castillo Alferez, Jessica, Zhang, Huan, Boender, Johan, Meijer, Stephan, Meijer, Karina, de Jong, Sean, Goedhart, Geertje, van der Bom, Anske, Bos, Mettine, Eikenboom, Jeroen, van der Meer, Felix, Laan, Sebastiaan, Schols, Saskia, Bierings, Ruben, Burdorf, Lex, Cnossen, Marjon, Hazelzet, Jan, Huisman, Elise, Kruip, Marieke, Leebeek, Frank, van Leeuwen, Nikki, Lingsma, Hester, de Maat, Moniek, van Moort, Iris, Polinder, Suzanne, Reitsma, Simone, Roest, Eliza, Arisz, Ryanne, Romano, Lorenzo, Al Arashi, Wala, van Hoorn, Shannon, Goedhart, Tine, Mussert, Caroline, Prameyllawati, Diaz, Uyl, Carin, Jansen, Nathalie, Fischer, Kathelijn, Ploos van Amstel, Hans Kristian, Urbanus, Rolf, Zivkovic, Minka, Bredenoord, Annelien, van der Graaf, Rieke, Baas, Lieke, Schutgens, Roger, Driessens, Mariëtte, Laan, Sebastiaan N.J., de Boer, Suzan, Dirven, Richard J., Kuipers, Thomas B., and Mei, Hailiang
Published: 2024
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40. Poor Rhinitis and Asthma Control Is Associated With Decreased Health-Related Quality of Life and Utilities: A MASK-air Study

Author: Czarlewski, Wienczyslawa, Bedbrook, Anna, Haahtela, Tari, Canonica, G. Walter, Costa, Elisio M., Kupczyk, Maciej, Kvedariene, Violeta, Kulus, Marek, Larenas-Linnemann, Désirée E., Pfaar, Oliver, Papadopoulos, Nikolaos G., Pham-Thi, Nhân, Regateiro, Frederico S., Roche, Nicolas, Sastre, Joaquin, Scichilone, Nicola, Taborda-Barata, Luis, Valiulis, Arunas, Yorgancioglu, Arzu, Ventura, Maria Teresa, Almeida, Rute, Amaral, Rita, Ansotegui, Ignacio J., Bergmann, Karl C., Bosnic-Anticevich, Sinthia, Braido, Fulvio, Brussino, Luisa, Cardona, Victoria, Cecchi, Lorenzo, Loureiro, Claudia Chaves, Cingi, Cemal, Cruz, Alvaro A., Fokkens, Wytske J., de Vries, Govert, Gemicioglu, Bilun, Giuliana, Antonio F.M., Linuma, Tomohisa, Ivancevich, Juan Carlos, Jácome, Cristina, Kaidashev, Igor, Kraxner, Helga, Laune, Daniel, Louis, Gilles, Lourenço, Olga, Makela, Mika, Makris, Michael, Mösges, Ralph, Maurer, Marcus, Mullol, Joaquim, Nadif, Rachel, Niedoszytko, Marek, O’Hehir, Robyn, Okamoto, Yoshitaka, Ollert, Markus, Olze, Heidi, Patella, Vincenzo, Pétré, Benoit, Puggioni, Francesca, Romantowski, Jan, Rouadi, Philip W., Reitsma, Sietze, Rivero-Yeverino, Daniela, Rodriguez-Gonzalez, Monica, Sá-Sousa, Ana, Serpa, Faradiba S., Shamji, Mohamed H., Sheikh, Aziz, Ulrik, Charlotte Suppli, Sofiev, Mikhail, Sova, Milan, Sperl, Annette, Todo-Bom, Ana, Tomazic, Peter V., Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valovirta, Erkka, van Eerd, Michiel, Zidarn, Mihaela, Blain, Hubert, Boulet, Louis-Philippe, Brusselle, Guy, Buhl, Roland, Charpin, Denis, Casale, Thomas, Chivato, Tomas, Correia-de-Sousa, Jaime, Corrigan, Christopher, de Blay, Frédéric, Del Giacco, Stefano, Devillier, Philippe, Dykewicz, Mark, Fiocchi, Alessandro, Giovannini, Mattia, Jassem, Ewa, Jutel, Marek, Keil, Thomas, La Grutta, Stefania, Lipworth, Brian, Papi, Alberto, Pépin, Jean-Louis, Quirce, Santiago, Cordeiro, Carlos Robalo, Torres, Maria J., Usmani, Omar S., Vieira, Rafael José, Leemann, Lucas, Briggs, Andrew, Pereira, Ana Margarida, Savouré, Marine, Kuna, Piotr, Morais-Almeida, Mário, Bewick, Michael, Azevedo, Luís Filipe, Louis, Renaud, Klimek, Ludger, Bahbah, Farah, Samolinski, Boleslaw, Anto, Josep M., Zuberbier, Torsten, Fonseca, João A., Bousquet, Jean, and Sousa-Pinto, Bernardo
Published: 2024
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41. SPIN-PM: a consensus framework to evaluate the presence of spin in studies on prediction models

Author: Andaur Navarro, Constanza L., Damen, Johanna A.A., Ghannad, Mona, Dhiman, Paula, van Smeden, Maarten, Reitsma, Johannes B., Collins, Gary S., Riley, Richard D., Moons, Karel G.M., and Hooft, Lotty
Published: 2024
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42. Vibrational relaxation of hot ground state cations of naphthalene

Author: Reitsma, Geert, Patchkovskii, Serguei, Dura, Judith, Drescher, Lorenz, Mikosch, Jochen, Vrakking, Marc J. J., and Kornilov, Oleg
Subjects: Physics - Chemical Physics
Abstract: Time-resolved XUV-IR photoion mass spectroscopy of naphthalene conducted with broadband, as well as with wavelength-selected narrowband XUV pulses reveals a rising probability of fragmentation characterized by a lifetime of $92\pm4$~fs. This lifetime is independent of the XUV excitation wavelength and is the same for all low appearance energy fragments recorded in the experiment. Analysis of the experimental data in conjunction with a statistical multi-state vibronic model suggests that the experimental signals track vibrational energy redistribution on the potential energy surface of the ground state cation. In particular, populations of the out-of-plane ring twist and the out-of-plane wave bending modes could be responsible for opening new IR absorption channels leading to enhanced fragmentation., Comment: Submitted to Daniel Neumark's Festschrift
Published: 2021
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43. A tutorial on individualized treatment effect prediction from randomized trials with a binary endpoint

Author: Hoogland, J, IntHout, J, Belias, M, Rovers, MM, Riley, RD, Harrell Jr, FE, Moons, KGM, Debray, TPA, and Reitsma, JB
Subjects: Statistics - Methodology
Abstract: Randomized trials typically estimate average relative treatment effects, but decisions on the benefit of a treatment are possibly better informed by more individualized predictions of the absolute treatment effect. In case of a binary outcome, these predictions of absolute individualized treatment effect require knowledge of the individual's risk without treatment and incorporation of a possibly differential treatment effect (i.e. varying with patient characteristics). In this paper we lay out the causal structure of individualized treatment effect in terms of potential outcomes and describe the required assumptions that underlie a causal interpretation of its prediction. Subsequently, we describe regression models and model estimation techniques that can be used to move from average to more individualized treatment effect predictions. We focus mainly on logistic regression-based methods that are both well-known and naturally provide the required probabilistic estimates. We incorporate key components from both causal inference and prediction research to arrive at individualized treatment effect predictions. While the separate components are well known, their successful amalgamation is very much an ongoing field of research. We cut the problem down to its essentials in the setting of a randomized trial, discuss the importance of a clear definition of the estimand of interest, provide insight into the required assumptions, and give guidance with respect to modeling and estimation options. Simulated data illustrates the potential of different modeling options across scenarios that vary both average treatment effect and treatment effect heterogeneity. Two applied examples illustrate individualized treatment effect prediction in randomized trial data., Comment: 27 pages, 5 figures, 1 ancillary file
Published: 2021
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44. Forgetfulness: The Holocaust Orphan Jay’s Lost Dutch-Jewish Family Story

Author: Richard Reitsma
Published: 2024

45. Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Author: Brauer, Michael, Roth, Gregory A, Aravkin, Aleksandr Y, Zheng, Peng, Abate, Kalkidan Hassen, Abate, Yohannes Habtegiorgis, Abbafati, Cristiana, Abbasgholizadeh, Rouzbeh, Abbasi, Madineh Akram, Abbasian, Mohammadreza, Abbasifard, Mitra, Abbasi-Kangevari, Mohsen, Abd ElHafeez, Samar, Abd-Elsalam, Sherief, Abdi, Parsa, Abdollahi, Mohammad, Abdoun, Meriem, Abdulah, Deldar Morad, Abdullahi, Auwal, Abebe, Mesfin, Abedi, Aidin, Abedi, Armita, Abegaz, Tadesse M, Abeldaño Zuñiga, Roberto Ariel, Abiodun, Olumide, Abiso, Temesgen Lera, Aboagye, Richard Gyan, Abolhassani, Hassan, Abouzid, Mohamed, Aboye, Girma Beressa, Abreu, Lucas Guimarães, Abualruz, Hasan, Abubakar, Bilyaminu, Abu-Gharbieh, Eman, Abukhadijah, Hana Jihad Jihad, Aburuz, Salahdein, Abu-Zaid, Ahmed, Adane, Mesafint Molla, Addo, Isaac Yeboah, Addolorato, Giovanni, Adedoyin, Rufus Adesoji, Adekanmbi, Victor, Aden, Bashir, Adetunji, Juliana Bunmi, Adeyeoluwa, Temitayo Esther, Adha, Rishan, Adibi, Amin, Adnani, Qorinah Estiningtyas Sakilah, Adzigbli, Leticia Akua, Afolabi, Aanuoluwapo Adeyimika, Afolabi, Rotimi Felix, Afshin, Ashkan, Afyouni, Shadi, Afzal, Muhammad Sohail, Afzal, Saira, Agampodi, Suneth Buddhika, Agbozo, Faith, Aghamiri, Shahin, Agodi, Antonella, Agrawal, Anurag, Agyemang-Duah, Williams, Ahinkorah, Bright Opoku, Ahmad, Aqeel, Ahmad, Danish, Ahmad, Firdos, Ahmad, Noah, Ahmad, Shahzaib, Ahmad, Tauseef, Ahmed, Ali, Ahmed, Anisuddin, Ahmed, Ayman, Ahmed, Luai A, Ahmed, Muktar Beshir, Ahmed, Safoora, Ahmed, Syed Anees, Ajami, Marjan, Akalu, Gizachew Taddesse, Akara, Essona Matatom, Akbarialiabad, Hossein, Akhlaghi, Shiva, Akinosoglou, Karolina, Akinyemiju, Tomi, Akkaif, Mohammed Ahmed, Akkala, Sreelatha, Akombi-Inyang, Blessing, Al Awaidy, Salah, Al Hasan, Syed Mahfuz, Alahdab, Fares, AL-Ahdal, Tareq Mohammed Ali, Alalalmeh, Samer O, Alalwan, Tariq A, Al-Aly, Ziyad, Alam, Khurshid, Alam, Nazmul, Alanezi, Fahad Mashhour, Alanzi, Turki M, Albakri, Almaza, AlBataineh, Mohammad T, Aldhaleei, Wafa A, Aldridge, Robert W, Alemayohu, Mulubirhan Assefa, Alemu, Yihun Mulugeta, Al-Fatly, Bassam, Al-Gheethi, Adel Ali Saeed, Al-Habbal, Khairat, Alhabib, Khalid F, Alhassan, Robert Kaba, Ali, Abid, Ali, Amjad, Ali, Beriwan Abdulqadir, Ali, Iman, Ali, Liaqat, Ali, Mohammed Usman, Ali, Rafat, Ali, Syed Shujait Shujait, Ali, Waad, Alicandro, Gianfranco, Alif, Sheikh Mohammad, Aljunid, Syed Mohamed, Alla, François, Al-Marwani, Sabah, Al-Mekhlafi, Hesham M, Almustanyir, Sami, Alomari, Mahmoud A, Alonso, Jordi, Alqahtani, Jaber S, Alqutaibi, Ahmed Yaseen, Al-Raddadi, Rajaa M, Alrawashdeh, Ahmad, Al-Rifai, Rami Hani, Alrousan, Sahel Majed, Al-Sabah, Salman Khalifah, Alshahrani, Najim Z, Altaany, Zaid, Altaf, Awais, Al-Tawfiq, Jaffar A, Altirkawi, Khalid A, Aluh, Deborah Oyine, Alvis-Guzman, Nelson, Alvis-Zakzuk, Nelson J, Alwafi, Hassan, Al-Wardat, Mohammad Sami, Al-Worafi, Yaser Mohammed, Aly, Hany, Aly, Safwat, Alzoubi, Karem H, Al-Zyoud, Walid, Amaechi, Uchenna Anderson, Aman Mohammadi, Masous, Amani, Reza, Amiri, Sohrab, Amirzade-Iranaq, Mohammad Hosein, Ammirati, Enrico, Amu, Hubert, Amugsi, Dickson A, Amusa, Ganiyu Adeniyi, Ancuceanu, Robert, Anderlini, Deanna, Anderson, Jason A, Andrade, Pedro Prata, Andrei, Catalina Liliana, Andrei, Tudorel, Anenberg, Susan C, Angappan, Dhanalakshmi, Angus, Colin, Anil, Abhishek, Anil, Sneha, Anjum, Afifa, Anoushiravani, Amir, Antonazzo, Ippazio Cosimo, Antony, Catherine M, Antriyandarti, Ernoiz, Anuoluwa, Boluwatife Stephen, Anvari, Davood, Anvari, Saeid, Anwar, Saleha, Anwar, Sumadi Lukman, Anwer, Razique, Anyabolo, Ekenedilichukwu Emmanuel, Anyasodor, Anayochukwu Edward, Apostol, Geminn Louis Carace, Arabloo, Jalal, Arabzadeh Bahri, Razman, Arafat, Mosab, Areda, Demelash, Aregawi, Brhane Berhe, Aremu, Abdulfatai, Armocida, Benedetta, Arndt, Michael Benjamin, Ärnlöv, Johan, Arooj, Mahwish, Artamonov, Anton A, Artanti, Kurnia Dwi, Aruleba, Idowu Thomas, Arumugam, Ashokan, Asbeutah, Akram M, Asgary, Saeed, Asgedom, Akeza Awealom, Ashbaugh, Charlie, Ashemo, Mubarek Yesse, Ashraf, Tahira, Askarinejad, Amir, Assmus, Michael, Astell-Burt, Thomas, Athar, Mohammad, Athari, Seyyed Shamsadin, Atorkey, Prince, Atreya, Alok, Aujayeb, Avinash, Ausloos, Marcel, Avila-Burgos, Leticia, Awoke, Andargie Abate, Ayala Quintanilla, Beatriz Paulina, Ayatollahi, Haleh, Ayestas Portugal, Carlos, Ayuso-Mateos, Jose L, Azadnajafabad, Sina, Azevedo, Rui M S, Azhar, Gulrez Shah, Azizi, Hosein, Azzam, Ahmed Y, Backhaus, Insa Linnea, Badar, Muhammad, Badiye, Ashish D, Bagga, Arvind, Baghdadi, Soroush, Bagheri, Nasser, Bagherieh, Sara, Bahrami Taghanaki, Pegah, Bai, Ruhai, Baig, Atif Amin, Baker, Jennifer L, Bakkannavar, Shankar M, Balasubramanian, Madhan, Baltatu, Ovidiu Constantin, Bam, Kiran, Bandyopadhyay, Soham, Banik, Biswajit, Banik, Palash Chandra, Banke-Thomas, Aduragbemi, Bansal, Hansi, Barchitta, Martina, Bardhan, Mainak, Bardideh, Erfan, Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Barone-Adesi, Francesco, Barqawi, Hiba Jawdat, Barrero, Lope H, Barrow, Amadou, Barteit, Sandra, Basharat, Zarrin, Basiru, Afisu, Basso, João Diogo, Bastan, Mohammad-Mahdi, Basu, Sanjay, Batchu, Sai, Batra, Kavita, Batra, Ravi, Baune, Bernhard T, Bayati, Mohsen, Bayileyegn, Nebiyou Simegnew, Beaney, Thomas, Behnoush, Amir Hossein, Beiranvand, Maryam, Béjot, Yannick, Bekele, Alehegn, Belgaumi, Uzma Iqbal, Bell, Arielle Wilder, Bell, Michelle L, Bello, Muhammad Bashir, Bello, Olorunjuwon Omolaja, Belo, Luis, Beloukas, Apostolos, Bendak, Salaheddine, Bennett, Derrick A, Bennitt, Fiona B, Bensenor, Isabela M, Benzian, Habib, Beran, Azizullah, Berezvai, Zombor, Bernabe, Eduardo, Bernstein, Robert S, Bettencourt, Paulo J G, Bhagavathula, Akshaya Srikanth, Bhala, Neeraj, Bhandari, Dinesh, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhaskar, Sonu, Bhat, Ajay Nagesh, Bhat, Vivek, Bhatti, Gurjit Kaur, Bhatti, Jasvinder Singh, Bhatti, Manpreet S, Bhatti, Rajbir, Bhuiyan, Mohiuddin Ahmed, Bhutta, Zulfiqar A, Bikbov, Boris, Bishai, Jessica Devin, Bisignano, Catherine, Biswas, Atanu, Biswas, Bijit, Biswas, Raaj Kishore, Bjørge, Tone, Boachie, Micheal Kofi, Boakye, Hosea, Bockarie, Moses John, Bodolica, Virginia, Bodunrin, Aadam Olalekan, Bogale, Eyob Ketema, Bolla, Srinivasa Rao, Boloor, Archith, Bonakdar Hashemi, Milad, Boppana, Sri Harsha, Bora Basara, Berrak, Borhany, Hamed, Botero Carvajal, Alejandro, Bouaoud, Souad, Boufous, Soufiane, Bourne, Rupert, Boxe, Christopher, Braithwaite, Dejana, Brant, Luisa C, Brar, Amanpreet, Breitborde, Nicholas J K, Breitner, Susanne, Brenner, Hermann, Briko, Andrey Nikolaevich, Britton, Gabrielle, Brown, Colin Stewart, Browne, Annie J, Brunoni, Andre R, Bryazka, Dana, Bulamu, Norma B, Bulto, Lemma N, Buonsenso, Danilo, Burkart, Katrin, Burns, Richard A, Busse, Reinhard, Bustanji, Yasser, Butt, Nadeem Shafique, Butt, Zahid A, Caetano dos Santos, Florentino Luciano, Cagney, Jack, Cahuana-Hurtado, Lucero, Calina, Daniela, Cámera, Luis Alberto, Campos, Luciana Aparecida, Campos-Nonato, Ismael R, Cao, Chao, Cao, Fan, Cao, Yubin, Capodici, Angelo, Cárdenas, Rosario, Carr, Sinclair, Carreras, Giulia, Carrero, Juan J, Carugno, Andrea, Carvalho, Felix, Carvalho, Márcia, Castaldelli-Maia, Joao Mauricio, Castañeda-Orjuela, Carlos A, Castelpietra, Giulio, Catalá-López, Ferrán, Catapano, Alberico L, Cattaruzza, Maria Sofia, Caye, Arthur, Cederroth, Christopher R, Cegolon, Luca, Cenderadewi, Muthia, Cercy, Kelly M, Cerin, Ester, Chadwick, Joshua, Chakraborty, Chiranjib, Chakraborty, Promit Ananyo, Chakraborty, Sandip, Chan, Jeffrey Shi Kai, Chan, Raymond N C, Chandan, Joht Singh, Chandika, Rama Mohan, Chaturvedi, Pankaj, Chen, An-Tian, Chen, Catherine S, Chen, Haowei, Chen, Meng Xuan, Chen, Mingling, Chen, Simiao, Cheng, Ching-Yu, Cheng, Esther T W, Cherbuin, Nicolas, Chi, Gerald, Chichagi, Fatemeh, Chimed-Ochir, Odgerel, Chimoriya, Ritesh, Ching, Patrick R, Chirinos-Caceres, Jesus Lorenzo, Chitheer, Abdulaal, Cho, William C S, Chong, Bryan, Chopra, Hitesh, Chowdhury, Rajiv, Christopher, Devasahayam J, Chu, Dinh-Toi, Chukwu, Isaac Sunday, Chung, Eric, Chung, Sheng-Chia, Chutiyami, Muhammad, Cioffi, Iolanda, Cogen, Rebecca M, Cohen, Aaron J, Columbus, Alyssa, Conde, Joao, Corlateanu, Alexandru, Cortese, Samuele, Cortesi, Paolo Angelo, Costa, Vera Marisa, Costanzo, Simona, Criqui, Michael H, Cruz, Jessica A, Cruz-Martins, Natália, Culbreth, Garland T, da Silva, Alanna Gomes, Dadras, Omid, Dai, Xiaochen, Dai, Zhaoli, Daikwo, Patience Unekwuojo, Dalli, Lachlan L, Damiani, Giovanni, D'Amico, Emanuele, D'Anna, Lucio, Darwesh, Aso Mohammad, Das, Jai K, Das, Subasish, Dash, Nihar Ranjan, Dashti, Mohsen, Dávila-Cervantes, Claudio Alberto, Davis Weaver, Nicole, Davitoiu, Dragos Virgil, De la Hoz, Fernando Pio, de la Torre-Luque, Alejandro, De Leo, Diego, Debopadhaya, Shayom, Degenhardt, Louisa, Del Bo', Cristian, Delgado-Enciso, Ivan, Delgado-Saborit, Juana Maria, Demoze, Chalachew Kassaw, Denova-Gutiérrez, Edgar, Dervenis, Nikolaos, Dervišević, Emina, Desai, Hardik Dineshbhai, Desai, Rupak, Devanbu, Vinoth Gnana Chellaiyan, Dewan, Syed Masudur Rahman, Dhali, Arkadeep, Dhama, Kuldeep, Dhane, Amol S, Dhimal, Mandira Lamichhane, Dhimal, Meghnath, Dhingra, Sameer, Dhulipala, Vishal R, Dhungana, Raja Ram, Dias da Silva, Diana, Diaz, Daniel, Diaz, Luis Antonio, Diaz, Michael J, Dima, Adriana, Ding, Delaney D, Dinu, Monica, Djalalinia, Shirin, Do, Thanh Chi, Do, Thao Huynh Phuong, do Prado, Camila Bruneli, Dodangeh, Masoud, Dohare, Sushil, Dokova, Klara Georgieva, Dong, Wanyue, Dongarwar, Deepa, D'Oria, Mario, Dorostkar, Fariba, Dorsey, E Ray, Doshi, Rajkumar, Doshmangir, Leila, Dowou, Robert Kokou, Driscoll, Tim Robert, Dsouza, Ashel Chelsea, Dsouza, Haneil Larson, Dumith, Samuel C, Duncan, Bruce B, Duraes, Andre Rodrigues, Duraisamy, Senbagam, Dushpanova, Anar, Dzianach, Paulina Agnieszka, Dziedzic, Arkadiusz Marian, Ebrahimi, Alireza, Echieh, Chidiebere Peter, Ed-Dra, Abdelaziz, Edinur, Hisham Atan, Edvardsson, David, Edvardsson, Kristina, Efendi, Ferry, Eftekharimehrabad, Aziz, Eini, Ebrahim, Ekholuenetale, Michael, Ekundayo, Temitope Cyrus, El Arab, Rabie Adel, El Sayed Zaki, Maysaa, El-Dahiyat, Faris, Elemam, Noha Mousaad, Elgar, Frank J, ElGohary, Ghada Metwally Tawfik, Elhabashy, Hala Rashad, Elhadi, Muhammed, Elmehrath, Ahmed O, Elmeligy, Omar Abdelsadek Abdou, Elshaer, Mohammed, Elsohaby, Ibrahim, Emeto, Theophilus I, Esfandiari, Negin, Eshrati, Babak, Eslami, Majid, Esmaeili, Sayed Vahid, Estep, Kara, Etaee, Farshid, Fabin, Natalia, Fagbamigbe, Adeniyi Francis, Fagbule, Omotayo Francis, Fahimi, Saman, Falzone, Luca, Fareed, Mohammad, Farinha, Carla Sofia e Sá, Faris, MoezAlIslam Ezzat Mahmoud, Faris, Pawan Sirwan, Faro, Andre, Fasina, Folorunso Oludayo, Fatehizadeh, Ali, Fauk, Nelsensius Klau, Fazylov, Timur, Feigin, Valery L, Feng, Xiaoqi, Fereshtehnejad, Seyed-Mohammad, Feroze, Abdullah Hamid, Ferrara, Pietro, Ferrari, Alize J, Ferreira, Nuno, Fetensa, Getahun, Feyisa, Bikila Regassa, Filip, Irina, Fischer, Florian, 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Hosseinzadeh, Hassan, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Hoven, Hanno, Hsairi, Mohamed, Hsu, Johnathan M, Hu, Chengxi, Huang, Junjie, Huda, Md Nazmul, Hulland, Erin N, Hultström, Michael, Hushmandi, Kiavash, Hussain, Javid, Hussein, Nawfal R, Huynh, Chantal K, Huynh, Hong-Han, Ibitoye, Segun Emmanuel, Idowu, Oluwatope Olaniyi, Ihler, Audrey L, Ikeda, Nayu, Ikuta, Kevin S, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Imam, Mohammad Tarique, Immurana, Mustapha, Inbaraj, Leeberk Raja, Irham, Lalu Muhammad, Isa, Mustafa Alhaji, Islam, Md Rabiul, Ismail, Faisal, Ismail, Nahlah Elkudssiah, Iso, Hiroyasu, Isola, Gaetano, Iwagami, Masao, Iwu, Chidozie C D, Iwu-Jaja, Chinwe Juliana, J, Vinothini, Jaafari, Jalil, Jacob, Louis, Jacobsen, Kathryn H, Jadidi-Niaragh, Farhad, Jahankhani, Kasra, Jahanmehr, Nader, Jahrami, Haitham, Jain, Akhil, Jain, Nityanand, Jairoun, Ammar Abdulrahman, Jaiswal, Abhishek, Jakovljevic, Mihajlo, Jalilzadeh Yengejeh, Reza, Jamora, Roland Dominic G, Jatau, Abubakar Ibrahim, Javadov, Sabzali, Javaheri, Tahereh, Jayaram, Shubha, Jeganathan, Jayakumar, Jeswani, Bijay Mukesh, Jiang, Heng, Johnson, Catherine O, Jokar, Mohammad, Jomehzadeh, Nabi, Jonas, Jost B, Joo, Tamas, Joseph, Abel, Joseph, Nitin, Joshi, Vivek, Joshua, Charity Ehimwenma, Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kaambwa, Billingsley, Kabir, Ali, Kabir, Zubair, Kadashetti, Vidya, Kahn, Ethan M, Kalani, Rizwan, Kaliyadan, Feroze, Kalra, Sanjay, Kamath, Rajesh, Kanagasabai, Thanigaivelan, Kanchan, Tanuj, Kandel, Himal, Kanmiki, Edmund Wedam, Kanmodi, Kehinde Kazeem, Kansal, Sushil Kumar, Kapner, Daniel John, Kapoor, Neeti, Karagiannidis, Efstratios, Karajizadeh, Mehrdad, Karakasis, Paschalis, Karanth, Shama D, Karaye, Ibraheem M, Karch, André, Karim, Asima, Karimi, Hanie, Karmakar, Shilpi, Kashoo, Faizan Zaffar, Kasraei, Hengameh, Kassahun, Woldeteklehaymanot Dagne, Kassebaum, Nicholas J, Kassel, Molly B, Katikireddi, Srinivasa Vittal, Kauppila, Joonas H, 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Samer H, Murray, Christopher J L, and Gakidou, Emmanuela
Published: 2024
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46. Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021

Author: Vollset, Stein Emil, Ababneh, Hazim S, Abate, Yohannes Habtegiorgis, Abbafati, Cristiana, Abbasgholizadeh, Rouzbeh, Abbasian, Mohammadreza, Abbastabar, Hedayat, Abd Al Magied, Abdallah H A, Abd ElHafeez, Samar, Abdelkader, Atef, Abdelmasseh, Michael, Abd-Elsalam, Sherief, Abdi, Parsa, Abdollahi, Mohammad, Abdoun, Meriem, Abdullahi, Auwal, Abebe, Mesfin, Abiodun, Olumide, Aboagye, Richard Gyan, Abolhassani, Hassan, Abouzid, Mohamed, Aboye, Girma Beressa, Abreu, Lucas Guimarães, Absalan, Abdorrahim, Abualruz, Hasan, Abubakar, Bilyaminu, Abukhadijah, Hana Jihad Jihad, Addolorato, Giovanni, Adekanmbi, Victor, Adetunji, Charles Oluwaseun, Adetunji, Juliana Bunmi, Adeyeoluwa, Temitayo Esther, Adha, Rishan, Adhikary, Ripon Kumar, Adnani, Qorinah Estiningtyas Sakilah, Adzigbli, Leticia Akua, Afrashteh, Fatemeh, Afzal, Muhammad Sohail, Afzal, Saira, Agbozo, Faith, Agodi, Antonella, Agrawal, Anurag, Agyemang-Duah, Williams, Ahinkorah, Bright Opoku, Ahlstrom, Austin J, Ahmad, Aqeel, Ahmad, Firdos, Ahmad, Muayyad M, Ahmad, Sajjad, Ahmad, Shahzaib, Ahmed, Anisuddin, Ahmed, Ayman, Ahmed, Haroon, Ahmed, Safoora, Ahmed, Syed Anees, Akinosoglou, Karolina, Akkaif, Mohammed Ahmed, Akrami, Ashley E, Akter, Ema, Al Awaidy, Salah, Al Hasan, Syed Mahfuz, Al Mosa, Amjad S, Al Ta'ani, Omar, Al Zaabi, Omar Ali Mohammed, Alahdab, Fares, Alajlani, Muaaz M, Al-Ajlouni, Yazan, Alalalmeh, Samer O, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore, Alam, Tahiya, Alam, Zufishan, Al-amer, Rasmieh Mustafa, Alanezi, Fahad Mashhour, Alanzi, Turki M, Albakri, Almaza, Aldhaleei, Wafa A, Aldridge, Robert W, Alemohammad, Seyedeh Yasaman, Alemu, Yihun Mulugeta, Al-Gheethi, Adel Ali Saeed, Al-Hanawi, Mohammed Khaled, Ali, Abid, Ali, Amjad, Ali, Iman, Ali, Mohammed Usman, Ali, Rafat, Ali, Syed Shujait Shujait, Ali, Victor Ekoche, Ali, Waad, Al-Ibraheem, Akram, Alicandro, Gianfranco, Alif, Sheikh Mohammad, Aljunid, Syed Mohamed, Alla, François, Almazan, Joseph Uy, Al-Mekhlafi, Hesham M, Alqutaibi, Ahmed Yaseen, Alrawashdeh, Ahmad, Alrousan, Sahel Majed, Al-Sabah, Salman Khalifah, Alsabri, Mohammed A, Altaany, Zaid, Al-Tammemi, Ala'a B., Al-Tawfiq, Jaffar A, Altirkawi, Khalid A, Aluh, Deborah Oyine, Alvis-Guzman, Nelson, Al-Wardat, Mohammad Sami, Al-Worafi, Yaser Mohammed, Aly, Hany, Alyahya, Mohammad Sharif, Alzoubi, Karem H, Al-Zyoud, Walid, Amani, Reza, Ameyaw, Edward Kwabena, Amin, Tarek Tawfik, Amindarolzarbi, Alireza, Amiri, Sohrab, Amirzade-Iranaq, Mohammad Hosein, Amu, Hubert, Amugsi, Dickson A, Ancuceanu, Robert, Anderlini, Deanna, Anderson, David B, Andrade, Pedro Prata, Andrei, Catalina Liliana, Andrei, Tudorel, Andrews, Erick Adrian, Anil, Abhishek, Anil, Sneha, Anoushiravani, Amir, Antony, Catherine M, Antriyandarti, Ernoiz, Anuoluwa, Boluwatife Stephen, Anvari, Saeid, Anyasodor, Anayochukwu Edward, Appiah, Francis, Aquilano, Michele, Arab, Juan Pablo, Arabloo, Jalal, Arafa, Elshaimaa A, Arafat, Mosab, Aravkin, Aleksandr Y, Ardekani, Ali, Areda, Demelash, Aregawi, Brhane Berhe, Aremu, Abdulfatai, Ariffin, Hany, Arkew, Mesay, Armani, Keivan, Artamonov, Anton A, Arumugam, Ashokan, Asghari-Jafarabadi, Mohammad, Ashbaugh, Charlie, Astell-Burt, Thomas, Athari, Seyyed Shamsadin, Atorkey, Prince, Atout, Maha Moh'd Wahbi, Aujayeb, Avinash, Ausloos, Marcel, Awad, Hamzeh, Awotidebe, Adedapo Wasiu, Ayatollahi, Haleh, Ayuso-Mateos, Jose L, Azadnajafabad, Sina, Azeez, Fahad Khan, Azevedo, Rui M S, Badar, Muhammad, Baghdadi, Soroush, Bagheri, Mahboube, Bagheri, Nasser, Bai, Ruhai, Baker, Jennifer L, Bako, Abdulaziz T, Balakrishnan, Senthilkumar, Balcha, Wondu Feyisa, Baltatu, Ovidiu Constantin, Barchitta, Martina, Bardideh, Erfan, Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Barqawi, Hiba Jawdat, Barteit, Sandra, Basiru, Afisu, Basso, João Diogo, Bastan, Mohammad-Mahdi, Basu, Sanjay, Bauckneht, Matteo, Baune, Bernhard T, Bayati, Mohsen, Bayileyegn, Nebiyou Simegnew, Behnoush, Amir Hossein, Behzadi, Payam, Beiranvand, Maryam, Bello, Olorunjuwon Omolaja, Belo, Luis, Beloukas, Apostolos, Bemanalizadeh, Maryam, Bensenor, Isabela M, Benzian, Habib, Beran, Azizullah, Berezvai, Zombor, Bernstein, Robert S, Bettencourt, Paulo J G, Beyene, Kebede A, Beyene, Melak Gedamu, Bhagat, Devidas S, Bhagavathula, Akshaya Srikanth, Bhala, Neeraj, Bhandari, Dinesh, Bharadwaj, Ravi, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhargava, Ashish, Bhaskar, Sonu, Bhat, Vivek, Bhattacharjee, Natalia V, Bhatti, Gurjit Kaur, Bhatti, Jasvinder Singh, Bhatti, Manpreet S, Bhuiyan, Mohiuddin Ahmed, Bisignano, Catherine, Biswas, Bijit, Bjørge, Tone, Bodolica, Virginia, Bodunrin, Aadam Olalekan, Bonakdar Hashemi, Milad, Bora Basara, Berrak, Borhany, Hamed, Bosoka, Samuel Adolf, Botero Carvajal, Alejandro, Bouaoud, Souad, Boufous, Soufiane, Boxe, Christopher, Boyko, Edward J, Brady, Oliver J, Braithwaite, Dejana, Brauer, Michael, Brazo-Sayavera, Javier, Brenner, Hermann, Brown, Colin Stewart, Browne, Annie J, Brugha, Traolach, Bryazka, Dana, Bulamu, Norma B, Buonsenso, Danilo, Burkart, Katrin, Burns, Richard A, Busse, Reinhard, Bustanji, Yasser, Butt, Zahid A, Caetano dos Santos, Florentino Luciano, Çakmak Barsbay, Mehtap, Calina, Daniela, Campos, Luciana Aparecida, Cao, Shujin, Capodici, Angelo, Cárdenas, Rosario, Carreras, Giulia, Carugno, Andrea, Carvalho, Márcia, Castaldelli-Maia, Joao Mauricio, Castelpietra, Giulio, Cattaruzza, Maria Sofia, Caye, Arthur, Cegolon, Luca, Cembranel, Francieli, Cenko, Edina, Cerin, Ester, Chadban, Steven J, Chadwick, Joshua, Chakraborty, Chiranjib, Chakraborty, Sandip, Chalek, Julian, Chan, Jeffrey Shi Kai, Chandika, Rama Mohan, Chandy, Sara, Charan, Jaykaran, Chaudhary, Anis Ahmad, Chaurasia, Akhilanand, Chen, An-Tian, Chen, Haowei, Chen, Meng Xuan, Chen, Simiao, Cherbuin, Nicolas, Chi, Gerald, Chichagi, Fatemeh, Chimed-Ochir, Odgerel, Chimoriya, Ritesh, Ching, Patrick R, Chirinos-Caceres, Jesus Lorenzo, Chitheer, Abdulaal, Cho, Daniel Youngwhan, Cho, William C S, Choi, Dong-Woo, Chong, Bryan, Chong, Chean Lin, Chopra, 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Robert Kokou, Dsouza, Haneil Larson, Dsouza, Viola, Dube, John, Dumith, Samuel C, Duncan, Bruce B, Duraes, Andre Rodrigues, Duraisamy, Senbagam, Durojaiye, Oyewole Christopher, Dushpanova, Anar, Dutta, Sulagna, Dzianach, Paulina Agnieszka, Dziedzic, Arkadiusz Marian, Eboreime, Ejemai, Ebrahimi, Alireza, Ebrahimi Kalan, Mohammad, Edinur, Hisham Atan, Efendi, Ferry, Eikemo, Terje Andreas, Eini, Ebrahim, Ekundayo, Temitope Cyrus, El Arab, Rabie Adel, El Sayed, Iman, Elamin, Osman, Elemam, Noha Mousaad, ElGohary, Ghada Metwally Tawfik, Elhadi, Muhammed, Elmeligy, Omar Abdelsadek Abdou, Elmoselhi, Adel B, Elshaer, Mohammed, Elsohaby, Ibrahim, Eltahir, Mohd. Elmagzoub, Emeto, Theophilus I, Eshrati, Babak, Eslami, Majid, Esmaeili, Zahra, Fabin, Natalia, Fagbamigbe, Adeniyi Francis, Fagbule, Omotayo Francis, Falzone, Luca, Fareed, Mohammad, Farinha, Carla Sofia e Sá, Faris, MoezAlIslam Ezzat Mahmoud, Faro, Andre, Fasihi, Kiana, Fatehizadeh, Ali, Fauk, Nelsensius Klau, Fazylov, Timur, Feigin, Valery L, Fekadu, Ginenus, Feng, Xiaoqi, Fereshtehnejad, Seyed-Mohammad, Ferrara, Pietro, Ferreira, Nuno, Firew, Belete Sewasew, Fischer, Florian, Fitriana, Ida, Flavel, Joanne, Flor, Luisa S, Folayan, Morenike Oluwatoyin, Foley, Kristen Marie, Fonzo, Marco, Force, Lisa M, Foschi, Matteo, Freitas, Alberto, Fridayani, Ni Kadek Yuni, Fukutaki, Kai Glenn, Furtado, João M, Fux, Blima, Gaal, Peter Andras, Gadanya, Muktar A, Gallus, Silvano, Ganesan, Balasankar, Ganiyani, Mohammad Arfat, Gautam, Rupesh K, Gebi, Tilaye Gebru, Gebregergis, Miglas W, Gebrehiwot, Mesfin, Getacher, Lemma, Getahun, Genanew K A, Gething, Peter W, Ghadimi, Delaram J, Ghadirian, Fataneh, Ghafarian, Sadegh, Ghailan, Khalid Yaser, Ghasemi, MohammadReza, Ghasempour Dabaghi, Ghazal, Ghazy, Ramy Mohamed, Ghoba, Sama, Gholami, Ehsan, Gholamrezanezhad, Ali, Gholizadeh, Nasim, Ghorbani, Mahsa, Ghorbani Vajargah, Pooyan, Ghotbi, Elena, Gil, Artyom Urievich, Gill, Tiffany K, Girmay, Alem, Glasbey, James C, Glushkova, Ekaterina Vladimirovna, Gnedovskaya, Elena V, Göbölös, Laszlo, Goldust, Mohamad, Goleij, Pouya, Golinelli, Davide, Gopalani, Sameer Vali, Goulart, Alessandra C, Gouravani, Mahdi, Goyal, Anmol, Grivna, Michal, Grosso, Giuseppe, Guarducci, Giovanni, Gubari, Mohammed Ibrahim Mohialdeen, Guicciardi, Stefano, Guimarães, Rafael Alves, Gulati, Snigdha, Gulisashvili, David, Gunawardane, Damitha Asanga, Guo, Cui, Gupta, Anish Kumar, Gupta, Rahul, Gupta, Rajeev, Gupta, Renu, Gupta, Sapna, Gupta, Vijai Kumar, Haakenstad, Annie, Hadi, Najah R, Haep, Nils, Hafiz, Abdul, Haghmorad, Dariush, Haile, Demewoz, Hajj Ali, Adel, Hajj Ali, Ali, Haj-Mirzaian, Arvin, Halboub, Esam S, Haller, Sebastian, Halwani, Rabih, Hamagharib Abdullah, Kanaan, Hamdy, Nadia M, Hamoudi, Rifat, Hanifi, Nasrin, Hankey, Graeme J, Haq, Zaim Anan, Haque, Md Rabiul, Harapan, Harapan, Hargono, Arief, Haro, Josep Maria, Hasaballah, Ahmed I, Hasan, S. M. Mahmudul, Hasanian, Mohammad, Hasnain, Md Saquib, Hassan, Amr, Haubold, Johannes, Hay, Simon I, Hebert, Jeffrey J, Hegazi, Omar E, Heidari, Mohammad, Hemmati, Mehdi, Henson, Claire A, Herrera-Serna, Brenda Yuliana, Herteliu, Claudiu, Heydari, Majid, Hezam, Kamal, Hidayana, Irma, Hiraike, Yuta, Hoan, Nguyen Quoc, Holla, Ramesh, Hoogar, Praveen, Horita, Nobuyuki, Hossain, Md Mahbub, Hosseinzadeh, Hassan, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Hu, Chengxi, Huang, Junjie, Hultström, Michael, Hundie, Tsegaye Gebreyes, Hunt, Aliza J, Hushmandi, Kiavash, Hussain, Javid, Hussain, M. Azhar, Hussein, Nawfal R, Huynh, Hong-Han, Hwang, Bing-Fang, Ibitoye, Segun Emmanuel, Iftikhar, Pulwasha Maria, Ikiroma, Adalia I, Ikwegbue, Paul Chukwudi, Ilic, Irena M, Ilic, Milena D, Immurana, Mustapha, Isa, Mustafa Alhaji, Islam, Md. Rabiul, Islam, Sheikh Mohammed Shariful, Ismail, Faisal, Ismail, Nahlah Elkudssiah, Isola, Gaetano, Iwagami, Masao, Iyamu, Ihoghosa Osamuyi, Jacob, Louis, Jacobsen, Kathryn H, Jafarinia, Morteza, Jahankhani, Kasra, Jahanmehr, Nader, Jain, Nityanand, Jairoun, Ammar Abdulrahman, Jakhmola Mani, Dr Ruchi, Jamil, Safayet, Jamora, Roland Dominic G, Jatau, Abubakar Ibrahim, Javadov, Sabzali, Javaheri, Tahereh, Jayaram, Shubha, Jee, Sun Ha, Jeganathan, Jayakumar, Jiang, Heng, Jokar, Mohammad, Jonas, Jost B, Joseph, Nitin, Joshua, Charity Ehimwenma, Jürisson, Mikk, K, Vaishali, Kabir, Ali, Kabir, Zubair, Kadashetti, Vidya, Kalankesh, Laleh R, Kalra, Sanjay, Kamath, Ashwin, Kamath, Rajesh, Kamireddy, Arun, Kanaan, Mona, Kanchan, Tanuj, Kanmiki, Edmund Wedam, Kanmodi, Kehinde Kazeem, Kansal, Sushil Kumar, Karim, Asima, Karkhah, Samad, Kashoo, Faizan Zaffar, Kasraei, Hengameh, Kassel, Molly B, Katikireddi, Srinivasa Vittal, Kauppila, Joonas H, Kaur, Harkiran, Kayode, Gbenga A, Kazemi, Foad, 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Kulkarni, Vishnutheertha, Kumar, G Anil, Kumar, Harish, Kumar, Nithin, Kumar, Rakesh, Kumar, Vijay, Kundu, Amartya, Kusuma, Dian, Kyei-Arthur, Frank, Kytö, Ville, Kyu, Hmwe Hmwe, La Vecchia, Carlo, Lacey, Ben, Ladan, Muhammad Awwal, Laflamme, Lucie, Lahariya, Chandrakant, Lai, Daphne Teck Ching, Lalloo, Ratilal, Lallukka, Tea, Lám, Judit, Lan, Qing, Lan, Tuo, Landires, Iván, Lanfranchi, Francesco, Langguth, Berthold, Lansingh, Van Charles, Laplante-Lévesque, Ariane, Larijani, Bagher, Larsson, Anders O, Lasrado, Savita, Lauriola, Paolo, Lawlor, Hilary R, Le, Huu-Hoai, Le, Long Khanh Dao, Le, Nhi Huu Hanh, Le, Thao Thi Thu, Le, Trang Diep Thanh, Leasher, Janet L, Lee, Doo Woong, Lee, Munjae, Lee, Paul H, Lee, Sang-woong, Lee, Seung Won, Lee, Shaun Wen Huey, Lee, Yo Han, Leigh, James, Leong, Elvynna, Li, Ming-Chieh, Libra, Massimo, Ligade, Virendra S, Lim, Lee-Ling, Lim, Stephen S, Limenh, Liknaw Workie, Lindholm, Daniel, Lindstedt, Paulina A, Listl, Stefan, Liu, Gang, Liu, Shiwei, Liu, 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Ahmed, Noroozi, Nafise, Nouri, Mehran, Nozari, Majid, Nri-Ezedi, Chisom Adaobi, Ntaios, George, Nunemo, Mengistu H, Nurrika, Dieta, Nutor, Jerry John, Nzoputam, Chimezie Igwegbe, Nzoputam, Ogochukwu Janet, Oancea, Bogdan, Obamiro, Kehinde O, Odetokun, Ismail A, Oduro, Michael Safo, Ogundijo, Oluwaseun Adeolu, Ogunfowokan, Adesola Adenike, Ogunkoya, Abiola, Oguntade, Ayodipupo Sikiru, Oh, In-Hwan, Ojo-Akosile, Tolulope R, Okati-Aliabad, Hassan, Okekunle, Akinkunmi Paul, Okonji, Osaretin Christabel, Olagunju, Andrew T, Olatubi, Matthew Idowu, Oliveira, Gláucia Maria Moraes, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Oluwafemi, Yinka Doris, Omar, Hany A, Omer, Goran Latif, Ong, Sokking, Onie, Sandersan, Onwujekwe, Obinna E, Opejin, Abdulahi Opejin, Ordak, Michal, Orish, Verner N, Ortiz, Alberto, Ortiz-Prado, Esteban, Osman, Wael M S, Ostojic, Sergej M, Ostroff, Samuel M, Osuagwu, Uchechukwu Levi, Otoiu, Adrian, Otstavnov, Stanislav S, Ouyahia, Amel, Owolabi, Mayowa O, Oyeyemi, Oyetunde T, Ozair, Ahmad, P A, Mahesh Padukudru, Padron-Monedero, Alicia, Padubidri, Jagadish Rao, Pal, Pramod Kumar, Palicz, Tamás, Pan, Feng, Pan, Hai-Feng, Panda-Jonas, Songhomitra, Pandey, Anamika, Pando-Robles, Victoria, Pangaribuan, Helena Ullyartha, Panos, Georgios D, Panos, Leonidas D, Pantazopoulos, Ioannis, Pantea Stoian, Anca Mihaela, Parikh, Romil R, Park, Eun-Kee, Park, Seoyeon, Park, Sungchul, Parsons, Nicholas, Parthasarathi, Ashwaghosha, Pasovic, Maja, Passera, Roberto, Patel, Jay, Pathan, Aslam Ramjan, Patil, Shankargouda, Patoulias, Dimitrios, Pawar, Shrikant, Pazoki Toroudi, Hamidreza, Pease, Spencer A, Peden, Amy E, Pedersini, Paolo, Pensato, Umberto, Pepito, Veincent Christian Filipino, Peprah, Prince, Pereira, Marcos, Pereira, Maria Odete, Perianayagam, Arokiasamy, Perico, Norberto, Perna, Simone, Pesudovs, Konrad, Petermann-Rocha, Fanny Emily, Pham, Hoang Tran, Philip, Anil K, Phillips, Michael R, Pigeolet, Manon, Piradov, Michael A, Pisoni, Enrico, Plotnikov, Evgenii, Poddighe, Dimitri, Polibin, Roman V, Poluru, Ramesh, Ponkilainen, Ville T, Popovic, Djordje S, Postma, Maarten J, Pour-Rashidi, Ahmad, Prabhu, Disha, Prada, Sergio I, Pradhan, Jalandhar, Pradhan, Pranil Man Singh, Prashant, Akila, Prates, Elton Junio Sady, Priscilla, Tina, Purnobasuki, Hery, Purohit, Bharathi M, Puvvula, Jagadeesh, Qasim, Nameer Hashim, Qattea, Ibrahim, Qazi, Asma Saleem, Qian, Gangzhen, Rabiee Rad, Mehrdad, Radhakrishnan, Venkatraman, Raeisi Shahraki, Hadi, Rafferty, Quinn, Raggi, Alberto, Raggi, Cat, Raheem, Nasiru, Rahim, Fakher, Rahim, Md Jillur, Rahimibarghani, Sarvenaz, Rahman, Md Mijanur Mijanur Rahman, Rahman, Mosiur, Rahman, Muhammad Aziz, Rahman, Tafhimur, Rahmani, Amir Masoud, Rahmanian, Mohammad, Rahmanian, Nazanin, Rahmati, Rahem, Rahmawaty, Setyaningrum, Raimondo, Diego, Raja, Adarsh, Rajput, Prashant, Ramadan, Majed, Ramasamy, Shakthi Kumaran, Ramazanu, Sheena, Ramteke, Pramod W, Rana, Kritika, Rana, Rishabh Kumar, Ranabhat, Chhabi Lal, Rane, Amey, Rao, Chythra R, Rao, Mithun, Rasella, Davide, Rashedi, Vahid, Rashid, Ahmed Mustafa, Rasouli-Saravani, Ashkan, Rastogi, Prateek, Rasul, Azad, Rathish, Devarajan, Rathnaiah Babu, Giridhara, Rauniyar, Santosh Kumar, Ravangard, Ramin, Rawaf, David Laith, Rawaf, Salman, Raza, Rabail Zehra, Redwan, Elrashdy Moustafa Mohamed, Reifels, Lennart, Reitsma, Marissa B, Remuzzi, Giuseppe, Rengasamy, Kannan RR, Reshmi, Bhageerathy, Resnikoff, Serge, Restaino, Stefano, Reyes, Luis Felipe, Rezaei, Nazila, Rezaei, Negar, Rezaei, Zahra Sadat, Rezaeian, Mohsen, Rhee, Taeho Gregory, Rickard, Jennifer, Robalik, Toshana, Robinson-Oden, Hannah Elizabeth, Rocha, Hermano Alexandre Lima, Rodrigues, Mónica, Rodriguez, Jefferson Antonio Buendia, Roever, Leonardo, Romadlon, Debby Syahru, Ronfani, Luca, Rony, Moustaq karim khan, Roshandel, Gholamreza, Rotimi, Kunle, Rout, Himanshu Sekhar, Roy, Bedanta, Rubagotti, Enrico, Ruela, Guilherme de Andrade, Rumisha, Susan Fred, Runghien, Tilleye, Russo, Michele, Saad, Aly M A, Saber, Korosh, Saber-Ayad, Maha Mohamed, Sabet, Cameron John, Sabour, Siamak, Sachdev, Perminder S, Saddler, Adam, Sadee, Bashdar Abuzed, Sadeghi, Masoumeh, Saeb, Mohammad Reza, Saeed, Umar, Safi, Sher Zaman, Sagar, Rajesh, Saghafi, Alireza, Sagoe, Dominic, Sahebkar, Amirhossein, Sahoo, Pragyan Monalisa, Sajid, Mirza Rizwan, Salam, Nasir, Salamati, Payman, Salami, Afeez Abolarinwa, Saleh, Mohamed A, Salehi, Leili, Salem, Marwa Rashad, Salemcity, Aanuoluwa James, Salimi, Sohrab, Samadi Kafil, Hossein, Samargandy, Saad, Samodra, Yoseph Leonardo, Samy, Abdallah M, Sanabria, Juan, Sanna, Francesca, Santric-Milicevic, Milena M, Sao Jose, Bruno Piassi, Saraswathy, Sivan Yegnanarayana Iyer, Saravanan, Aswini, Sarmiento-Suárez, Rodrigo, Sarode, Gargi Sachin, Sarode, Sachin C, Sartorius, Benn, Satpathy, Maheswar, Sayeed, Abu, Scarmeas, Nikolaos, Schaarschmidt, Benedikt Michael, Schinckus, Christophe, Schuermans, Art, Schumacher, Austin E, Schutte, Aletta Elisabeth, Schwebel, David C, Schwendicke, Falk, Selvaraj, Siddharthan, Semreen, Mohammad H, Senapati, Sabyasachi, Sengupta, Pallav, Senthilkumaran, Subramanian, Serban, Dragos, Sethi, Yashendra, Seylani, Allen, Shafie, Mahan, Shah, Pritik A, Shahbandi, Ataollah, Shahid, Samiah, Shahid, Wajeehah, Shahsavari, Hamid R, Shahwan, Moyad Jamal, Shaikh, Masood Ali, Shalash, Ali S, Shamekh, Ali, Shamim, Muhammad Aaqib, Shanawaz, Mohd, Shankar, Abhishek, Shannawaz, Mohammed, Sharath, Medha, Sharfaei, Sadaf, Sharifan, Amin, Sharifi-Rad, Javad, Sharma, Anupam, Sharma, Manoj, Sharma, Saurab, Sharma, Vishal, Shastry, Rajesh P, Shayan, Maryam, Shekhar, Shashank, Shenoy, Rekha R, Shetty, Mahabalesh, Shetty, Pavanchand H, Shetty, Premalatha K, Shi, Peilin, Shiani, Amir, Shigematsu, Mika, Shimels, Tariku, Shiri, Rahman, Shittu, Aminu, Shiue, Ivy, Shivakumar, K M, Shool, Sina, Shorofi, Seyed Afshin, Shrestha, Sunil, Shuval, Kerem, Si, Yafei, Siddig, Emmanuel Edwar, Sidhu, Jaspreet Kaur, Silva, João Pedro, Silva, Luís Manuel Lopes Rodrigues, Silva, Soraia, Silva, Thales Philipe R, Simpson, Colin R, Simpson, Kyle E, Singh, Abhinav, Singh, Balbir Bagicha, Singh, Baljinder, Singh, Harmanjit, Singh, Jasbir, Singh, Paramdeep, Singh, Puneetpal, Skou, Søren T, Smith, Georgia, Sobia, Farrukh, Socea, Bogdan, Solanki, Shipra, Soleimani, Hamidreza, Soliman, Sameh S M, Song, Yi, Soyiri, Ireneous N, Spartalis, Michael, Spearman, Sandra, Sreeramareddy, Chandrashekhar T, Stanaway, Jeffrey D, Stanikzai, Muhammad Haroon, Starodubova, Antonina V, Stein, Dan J, Steiner, Caitlyn, Steiropoulos, Paschalis, Stockfelt, Leo, Stokes, Mark A, Straif, Kurt, Subedi, Narayan, Suliankatchi Abdulkader, Rizwan, Sultana, Abida, Sun, Jing, Sundström, Johan, Swain, Chandan Kumar, Szarpak, Lukasz, Szeto, Mindy D, Tabaee Damavandi, Payam, Tabarés-Seisdedos, Rafael, Tabatabaei Malazy, Ozra, Tabatabaeizadeh, Seyed-Amir, Tabatabai, Shima, Tabb, Karen M, Tabche, Celine, Tabish, Mohammad, Taheri Abkenar, Yasaman, Taheri Soodejani, Moslem, Taiba, Jabeen, Talaat, Iman M, Tamuzi, Jacques Lukenze, Tan, Ker-Kan, Tang, Haosu, Tat, Nathan Y, Tavakoli Oliaee, Razieh, Tavangar, Seyed Mohammad, Taveira, Nuno, Tbakhi, Abdelghani, Tehrani, Hadi, Temsah, Mohamad-Hani, Teramoto, Masayuki, Tesfaye, Behailu Terefe, Teye-Kwadjo, Enoch, Thangaraju, Pugazhenthan, Thankappan, Kavumpurathu Raman, Thapar, Rekha, Thayakaran, Rasiah, Thirunavukkarasu, Sathish, Thomas, Nihal, Thygesen, Lau Caspar, Ticoalu, Jansje Henny Vera, Timalsena, Dinesh, Tiruye, Tenaw Yimer, Tiwari, Krishna, Tomo, Sojit, Tonelli, Marcello, Topor-Madry, Roman, Touvier, Mathilde, Tovani-Palone, Marcos Roberto, Tran, An Thien, Tran, Jasmine T, Tran, Nghia Minh, Tran, Thang Huu, Trico, Domenico, Tromans, Samuel Joseph, Truyen, Thien Tan Tri Tai, Tsatsakis, Aristidis, Tsermpini, Evangelia Eirini, Tumurkhuu, Munkhtuya, Turnock, Steven T, Udoh, Arit, Ullah, Atta, Ullah, Saeed, Ullah, Sana, Umakanthan, Srikanth, Umar, Muhammad, Umar, Shehu Salihu, Unim, Brigid, Unnikrishnan, Bhaskaran, Upadhyay, Era, Usman, Jibrin Sammani, Vahdati, Sanaz, Vaithinathan, Asokan Govindaraj, Vakili, Omid, Valizadeh, Rohollah, Van den Eynde, Jef, Vart, Priya, Varthya, Shoban Babu, Vasankari, Tommi Juhani, Vasic, Milena, Venketasubramanian, Narayanaswamy, Veroux, Massimiliano, Verras, Georgios-Ioannis, Vervoort, Dominique, Vijayageetha, Mathavaswami, Villafañe, Jorge Hugo, Vinayak, Manish, Violante, Francesco S, Vladimirov, Sergey Konstantinovitch, Vlassov, Vasily, Vo, Bay, Vohra, Karn, Vos, Theo, Wadood, Abdul Wadood, Waheed, Yasir, Wang, Fang, Wang, Shaopan, Wang, Shu, Wang, Yanqing, Wang, Yanzhong, Wang, Yuan-Pang, Wanjau, Mary Njeri, Waqas, Muhammad, Ward, Paul, Waris, Abdul, Wassie, Emebet Gashaw, Watson, Stefanie, Weaver, Marcia R, Weerakoon, Kosala Gayan, Weintraub, Robert G, Weldetinsaa, Haftom Legese Legese, Wells, Katherine M, Wen, Yi Feng, Westerman, Ronny, Wiangkham, Taweewat, Wickramasinghe, Dakshitha Praneeth, Widowati, Evi, Wojewodzic, Marcin W, Woldeyes, Dawit Habte, Wolf, Axel Walter, Wolfe, Charles D A, Wu, Chenkai, Wu, Dongze, Wu, Felicia, Wu, Jiayuan, Wu, Zenghong, Wulf Hanson, Sarah, Xiao, Hong, Xu, Suowen, Yadav, Rakesh, Yamagishi, Kazumasa, Yang, Danting, Yano, Yuichiro, Yarahmadi, Amir, Yazdani Nia, Iman, Ye, Pengpeng, Yesodharan, Renjulal, Yesuf, Subah Abderehim, Yezli, Saber, Yiğit, Arzu, Yiğit, Vahit, Yigzaw, Zeamanuel Anteneh, Yin, Dehui, Yip, Paul, Yonemoto, Naohiro, You, Yuyi, Younis, Mustafa Z, Yu, Chuanhua, Yu, Elaine A, Yu, Yong, Yuan, Chun-Wei, Yusuf, Hadiza, Zafar, Uzma, Zafari, Nima, Zahid, Mondal Hasan, Zakham, Fathiah, Zaki, Nazar, Zerfu, Taddese Alemu, Zhang, Haijun, Zhang, Jingya, Zhang, Liqun, Zhang, Yunquan, Zhang, Zhiqiang, Zhao, Xiu-Ju George, Zhao, Yang, Zhao, Zhongyi, Zhong, Chenwen, Zhou, Bolun, Zhou, Juexiao, Zhou, Shangcheng, Zhu, Bin, Zhumagaliuly, Abzal, Zielińska, Magdalena, Zoghi, Ghazal, Zumla, Alimuddin, Zyoud, Sa'ed H, Zyoud, Samer H, Smith, Amanda E, and Murray, Christopher J L
Published: 2024
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47. Developing a theory of change model for a learning and innovation network: A qualitative study

Author: Albers, M.(Marjolein), Reitsma, M.(Margreet), Benning, K.(Kelsey), Gobbens, R.J.J.(Robbert), Timmermans, O.A.A.M.J.(Olaf), and Nies, H.L.G.R.(Henk)
Published: 2024
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48. Comparing methods addressing multi-collinearity when developing prediction models

Author: Leeuwenberg, Artuur M., van Smeden, Maarten, Langendijk, Johannes A., van der Schaaf, Arjen, Mauer, Murielle E., Moons, Karel G. M., Reitsma, Johannes B., and Schuit, Ewoud
Subjects: Statistics - Methodology, 60, G.3
Abstract: Clinical prediction models are developed widely across medical disciplines. When predictors in such models are highly collinear, unexpected or spurious predictor-outcome associations may occur, thereby potentially reducing face-validity and explainability of the prediction model. Collinearity can be dealt with by exclusion of collinear predictors, but when there is no a priori motivation (besides collinearity) to include or exclude specific predictors, such an approach is arbitrary and possibly inappropriate. We compare different methods to address collinearity, including shrinkage, dimensionality reduction, and constrained optimization. The effectiveness of these methods is illustrated via simulations. In the conducted simulations, no effect of collinearity was observed on predictive outcomes. However, a negative effect of collinearity on the stability of predictor selection was found, affecting all compared methods, but in particular methods that perform strong predictor selection (e.g., Lasso).}
Published: 2021

49. Prognosis and prediction of antibiotic benefit in adults with clinically diagnosed acute rhinosinusitis: an individual participant data meta-analysis

Author: Jeroen Hoogland, Toshihiko Takada, Maarten van Smeden, Maroeska M. Rovers, An I. de Sutter, Daniel Merenstein, Laurent Kaiser, Helena Liira, Paul Little, Heiner C. Bucher, Karel G. M. Moons, Johannes B. Reitsma, and Roderick P. Venekamp
Subjects: Individual participant data meta-analysis, Randomized controlled trial, Acute rhinosinusitis, Antibiotic treatment, Individualized treatment effect, Prediction, Medicine (General), R5-920
Abstract: Abstract Background A previous individual participant data meta-analysis (IPD-MA) of antibiotics for adults with clinically diagnosed acute rhinosinusitis (ARS) showed a marginal overall effect of antibiotics, but was unable to identify patients that are most likely to benefit from antibiotics when applying conventional (i.e. univariable or one-variable-at-a-time) subgroup analysis. We updated the systematic review and investigated whether multivariable prediction of patient-level prognosis and antibiotic treatment effect may lead to more tailored treatment assignment in adults presenting to primary care with ARS. Methods An IPD-MA of nine double-blind placebo-controlled trials of antibiotic treatment (n=2539) was conducted, with the probability of being cured at 8–15 days as the primary outcome. A logistic mixed effects model was developed to predict the probability of being cured based on demographic characteristics, signs and symptoms, and antibiotic treatment assignment. Predictive performance was quantified based on internal-external cross-validation in terms of calibration and discrimination performance, overall model fit, and the accuracy of individual predictions. Results Results indicate that the prognosis with respect to risk of cure could not be reliably predicted (c-statistic 0.58 and Brier score 0.24). Similarly, patient-level treatment effect predictions did not reliably distinguish between those that did and did not benefit from antibiotics (c-for-benefit 0.50). Conclusions In conclusion, multivariable prediction based on patient demographics and common signs and symptoms did not reliably predict the patient-level probability of cure and antibiotic effect in this IPD-MA. Therefore, these characteristics cannot be expected to reliably distinguish those that do and do not benefit from antibiotics in adults presenting to primary care with ARS.
Published: 2023
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50. Pre-asthma: a useful concept? A EUFOREA paper. Part 2—late onset eosinophilic asthma

Author: G. K. Scadding, C. Gray, D. M. Conti, M. McDonald, V. Backer, G. Scadding, M. Bernal-Sprekelsen, E. De Corso, Z. Diamant, C. Hopkins, M. Jesenak, P. Johansen, J. Kappen, J. Mullol, D. Price, S. Quirce, S. Reitsma, S. Toppila-Salmi, B. Senior, J. P. Thyssen, U. Wahn, and P. W. Hellings
Subjects: late onset asthma, non-allergic rhinitis, chronic rhinosinusitis with nasal polyps, eosinophils, mast cells, virulence genes, Immunologic diseases. Allergy, RC581-607
Abstract: The concept of pre-diabetes has led to provision of measures to reduce disease progression through identification of subjects at risk of diabetes. We previously considered the idea of pre-asthma in relation to allergic asthma and considered that, in addition to the need to improve population health via multiple measures, including reduction of exposure to allergens and pollutants and avoidance of obesity, there are several possible specific means to reduce asthma development in those most at risk (pre- asthma). The most obvious is allergen immunotherapy (AIT), which when given for allergic rhinitis (AR) has reasonable evidence to support asthma prevention in children (2) but also needs further study as primary prevention. In this second paper we explore the possibilities for similar actions in late onset eosinophilic asthma.
Published: 2024
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