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14. Superficial siderosis of the spinal cord: a rare cause of myelopathy diagnosed by MRI

Author

Offenbacher, H., Fazekas, F., Reisecker, F., Schmidt, R., Payer, F., and Lechner, H.

Subjects
Magnetic resonance imaging, Subarachnoid hemorrhage -- Complications, Central nervous system diseases -- Causes of, Health, Psychology and mental health
Abstract

Hemosiderin is an iron-containing pigment that results from the breakdown of hemoglobin. Under rare circumstances, hemosiderin may deposit in the meninges, which cover the brain and spinal cord; this condition is known as superficial siderosis. The deposition of hemosiderin in the meninges is the result of repeated hemorrhage into the subarachnoid space surrounding the central nervous system. The symptoms of superficial siderosis are hearing loss, problems walking, spinal cord symptoms, and progressive dementia; clearly, these symptoms may occur with a variety of different disorders and none is specific for superficial siderosis. For this reason, the diagnosis of superficial siderosis has traditionally been made only by direct examination of the affected tissues. However, the advent of magnetic resonance imaging (MRI) has changed this. The iron-containing deposits appear as marked areas of hypointensity (white-appearing areas) on MRI. In the present case, a 66-year-old woman was admitted for worsening of neurological symptoms, which had begun six years previously. At that time a neurological work-up revealed the normally colorless cerebrospinal fluid to be yellow, and CT scan revealed some mild atrophy of the cerebellum. The patient experienced episodes of headache, vomiting, blurred vision, and dizziness in the intervening years. MRI revealed that the outer area of the spinal cord was markedly hypointense, suggesting superficial siderosis. Angiography was performed on the cerebral blood vessels, but no blood vessel abnormality which might account for the repeated bleeding could be identified. In the present case, however, it seems likely that the episodes of headache and vomiting coincided with episodes of subarachnoid bleeding. The toxic effects of iron contribute to the destruction of myelin sheaths in the white matter, the destruction of neurons, and the proliferation of glial cells in a typical nervous system ''scarring'' response. In general, the encrustation of iron is already severe by the time clinical symptoms first appear. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

15. Der Hirnabszeß: Prognostische Faktoren

Author

Witzmann A, Reisecker F, F. Leblhuber, Beran H, and Böhm-Jurkovic H

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, Computed tomography, General Medicine, Ventricular system, medicine.disease, Clouded consciousness, Level of consciousness, Medicine, Radiology, business, Abscess, Brain abscess, Multiple abscesses
Abstract

Thirty-eight cases of cerebral abscess were analysed retrospectively for any factors that might influence outcome. Using the "Glasgow outcome score", age, history, level of consciousness, as well as various computed tomography findings (cisternal swelling, compression of the ventricular system, degree of oedema and size of abscess) were considered for their prognostic value. It was found that age over 40 years and clouded consciousness exerted a statistically significant unfavourable effect (P less than 0.05). Outcome was also unfavourable in half the patients with multiple abscesses, but the number of cases (six) was too small to be statistically significant. All other variables had no statistically significant influence on prognosis.

Published
2008
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25. Hypervolemic haemodilution and completed stroke: how important is the application time for its effect?

Author

W Langsteger, Eber O, P Költringer, and Reisecker F

Subjects
Adult, Male, Hemodilution, Time Factors, business.industry, Whole blood viscosity, General Medicine, Hydroxyethyl starch, Middle Aged, Application time, Group B, Cerebrovascular Disorders, Neurology, Anesthesia, Medicine, Humans, Female, Neurology (clinical), business, Plasma viscosity, Rheology, Completed stroke, medicine.drug, Aged
Abstract

In 75 patients with completed stroke hypervolemic haemodilution was performed for 1 day with 500 ml 6% HES 200.000/0.6-0.66 (Elohäst) to test the acute influence of application time for haemorheological changes. The patients were divided into 3 groups randomly selected: group A received the infusion for 2 hours, group B for 4 hours and group C for 6 hours. Haematocrit (HCT), whole blood viscosity (VI-VB), blood elasticity (EL-VB) and plasma viscosity (VI-PL) were determined before onset of infusion, after 6 and 18 hours subsequently. The values obtained were compared with the onset results. In all groups and parameters after 6 hours there was a significant decrease. After 18 hours group A showed a significant higher value of HCT and increasing trends for VI-VB and EL-VB. In group B after 18 hours a significant decrease of VI-VB could be observed. In group C all values remained significantly below the onset. The results show, that one important haemorheological argument for an effective form of haemodilution should also be a long application time. This might be one of the reasons, why in some studies with hypervolemic haemodilution no positive results could be obtained.

Published
1992

34. Age-related changes in autonomic nerve function in skin

Author

Werner Langsteger, Peter Költringer, P. Lind, O. Eber, and Reisecker F

Subjects
medicine.medical_specialty, Autonomic nerve, business.industry, General Neuroscience, Internal medicine, Age related, Cardiology, Medicine, Neurology (clinical), business, Function (biology)
Published
1990
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45. Dehydroepiandrosterone sulphate in Alzheimer's disease

Author

Leblhuber, F., primary, Windhager, E., additional, Reisecker, F., additional, Steinparz, F.X., additional, Dienstl, E., additional, Cuckle, H., additional, Stone, R., additional, Smith, D., additional, Wald, N., additional, Brammer, M., additional, Hajimohammedreza, I., additional, Levy, R., additional, Chard, T., additional, and Perry, L., additional

Published
1990
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50. Visual evoked potentials in graves' disease

Author

Peter Költringer, Werner Langsteger, P. Lind, O. Eber, and Reisecker F

Subjects
medicine.medical_specialty, business.industry, General Neuroscience, Graves' disease, Medicine, Neurology (clinical), Visual evoked potentials, Audiology, business, medicine.disease
Published
1990
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