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6. Expanded ILC2s in human infant intestines promote tissue-growth

Author

Möller, KJ, primary, Wegner, LHM, additional, Malsy, J, additional, Baumdick, ME, additional, Borggrewe, M, additional, Jordan-Paiz, A, additional, Jung, JM, additional, Martrus, G, additional, Kretschmer, P, additional, Sagebiel, AF, additional, Schreurs, RRCE, additional, Hagen, SH, additional, Burmester, G, additional, Clauditz, TS, additional, Pals, ST, additional, Boettcher, M, additional, Melling, N, additional, Sauter, G, additional, Tomuschat, C, additional, Königs, I, additional, Schumacher, U, additional, Altfeld, M, additional, Bernink, JH, additional, Perez, D, additional, Reinshagen, K, additional, and Bunders, MJ, additional

Published
2023
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7. First genome-wide association study of esophageal atresia identifies three genetic risk loci at CTNNA3, FOXF1/FOXC2/FOXL1, and HNF1B

Author

Gehlen, J., Giel, A.S., Köllges, R., Haas, S.L., Zhang, R., Trcka, J., Sungur, A., Renziehausen, F., Bornholdt, D., Jung, D., Hoyer, P.D., Nordenskjöld, A., Tibboel, D., Vlot, J., Spaander, M.C., Smigiel, R., Patkowski, D., Roeleveld, N., Rooij, I.A.L.M. van, Blaauw, I. de, Hölscher, A., Pauly, M., Leutner, A., Fuchs, J., Niethammer, J., Melissari, M.T., Jenetzky, E., Zwink, N., Thiele, H., Hilger, A.C., Hess, T., Trautmann, J., Marks, M., Baumgarten, M., Bläss, G., Landén, M., Fundin, B., Bulik, C.M., Pennimpede, T., Ludwig, M., Ludwig, K.U., Mangold, E., Heilmann-Heimbach, S., Moebus, S., Herrmann, B.G., Alsabeah, K., Burgos, C.M., Lilja, H.E., Azodi, S., Stenström, P., Arnbjörnsson, E., Frybova, B., Lebensztejn, D.M., Debek, W., Kolodziejczyk, E., Kozera, K., Kierkus, J., Kaliciński, P., Stefanowicz, M., Socha-Banasiak, A., Kolejwa, M., Piaseczna-Piotrowska, A., Czkwianianc, E., Nöthen, M.M., Grote, P., Rygl, M., Reinshagen, K., Spychalski, N., Ludwikowski, B., Hubertus, J., Heydweiller, A., Ure, B., Muensterer, O.J., Aubert, O., Gosemann, J.H., Lacher, M., Degenhardt, P., Boemers, T.M., Mokrowiecka, A., Małecka-Panas, E., Wöhr, M., Knapp, M., Seitz, G., Klein, A., Oracz, G., Brosens, E., Reutter, H., Schumacher, J., Gehlen, J., Giel, A.S., Köllges, R., Haas, S.L., Zhang, R., Trcka, J., Sungur, A., Renziehausen, F., Bornholdt, D., Jung, D., Hoyer, P.D., Nordenskjöld, A., Tibboel, D., Vlot, J., Spaander, M.C., Smigiel, R., Patkowski, D., Roeleveld, N., Rooij, I.A.L.M. van, Blaauw, I. de, Hölscher, A., Pauly, M., Leutner, A., Fuchs, J., Niethammer, J., Melissari, M.T., Jenetzky, E., Zwink, N., Thiele, H., Hilger, A.C., Hess, T., Trautmann, J., Marks, M., Baumgarten, M., Bläss, G., Landén, M., Fundin, B., Bulik, C.M., Pennimpede, T., Ludwig, M., Ludwig, K.U., Mangold, E., Heilmann-Heimbach, S., Moebus, S., Herrmann, B.G., Alsabeah, K., Burgos, C.M., Lilja, H.E., Azodi, S., Stenström, P., Arnbjörnsson, E., Frybova, B., Lebensztejn, D.M., Debek, W., Kolodziejczyk, E., Kozera, K., Kierkus, J., Kaliciński, P., Stefanowicz, M., Socha-Banasiak, A., Kolejwa, M., Piaseczna-Piotrowska, A., Czkwianianc, E., Nöthen, M.M., Grote, P., Rygl, M., Reinshagen, K., Spychalski, N., Ludwikowski, B., Hubertus, J., Heydweiller, A., Ure, B., Muensterer, O.J., Aubert, O., Gosemann, J.H., Lacher, M., Degenhardt, P., Boemers, T.M., Mokrowiecka, A., Małecka-Panas, E., Wöhr, M., Knapp, M., Seitz, G., Klein, A., Oracz, G., Brosens, E., Reutter, H., and Schumacher, J.

Abstract

Item does not contain fulltext, Esophageal atresia with or without tracheoesophageal fistula (EA/TEF) is the most common congenital malformation of the upper digestive tract. This study represents the first genome-wide association study (GWAS) to identify risk loci for EA/TEF. We used a European case-control sample comprising 764 EA/TEF patients and 5,778 controls and observed genome-wide significant associations at three loci. On chromosome 10q21 within the gene CTNNA3 (p = 2.11 × 10(-8); odds ratio [OR] = 3.94; 95% confidence interval [CI], 3.10-5.00), on chromosome 16q24 next to the FOX gene cluster (p = 2.25 × 10(-10); OR = 1.47; 95% CI, 1.38-1.55) and on chromosome 17q12 next to the gene HNF1B (p = 3.35 × 10(-16); OR = 1.75; 95% CI, 1.64-1.87). We next carried out an esophageal/tracheal transcriptome profiling in rat embryos at four selected embryonic time points. Based on these data and on already published data, the implicated genes at all three GWAS loci are promising candidates for EA/TEF development. We also analyzed the genetic EA/TEF architecture beyond the single marker level, which revealed an estimated single-nucleotide polymorphism (SNP)-based heritability of around 37% ± 14% standard deviation. In addition, we examined the polygenicity of EA/TEF and found that EA/TEF is less polygenic than other complex genetic diseases. In conclusion, the results of our study contribute to a better understanding on the underlying genetic architecture of ET/TEF with the identification of three risk loci and candidate genes.

Published
2022

13. Intestinal CD8+ T cell responses are abundantly induced early in human development but show impaired cytotoxic effector capacities

Author

Schreurs, R. R. C.E., primary, Sagebiel, A.F., additional, Steinert, F.L., additional, Highton, A.J., additional, Klarenbeek, P.L., additional, Drewniak, A., additional, Bakx, R., additional, The, S. M.L., additional, Ribeiro, C. M.S., additional, Perez, D., additional, Reinshagen, K., additional, Geijtenbeek, T. B.H., additional, van Goudoever, J.B., additional, and Bunders, M.J., additional

Published
2021
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14. Using AI to predict the length of hospitalization in pediatric burn patients

Author

Elrod, J., Mohr, C., Wolff, R., Reinshagen, K., Committee Of The German Burn Registry, and Königs, Ingo

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Introduction: Prediction of length of stay (LOS) is of great importance in burn patients. This study aims at investigating the prediction accuracy of complex models and a linear regression-based approach. The heuristic expecting 1 day of stay per % total body surface area (TBSA) commonly applied[for full text, please go to the a.m. URL], 38. Jahrestagung der Deutschsprachigen Arbeitsgemeinschaft für Verbrennungsbehandlung (DAV 2020)

Published
2020

15. Der ABSI ist tot, lang lebe der ABSI – zuverlässige Vorhersage des Überlebens durch Modifikation des Abbreviated Burn Severity Index

Author

Bartels, P, Thamm, OC, Fuchs, P, Elrod, J, Reinshagen, K, and Königs, I

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Der Abbreviated Burn Severity Index (ABSI), 1982 von Tobiasen et al. entwickelt, ist ein weltweit genutzter, einfach anwendbarer Score zur Einschätzung der Überlebenswahrscheinlichkeit nach Verbrennungsverletzungen. Aufgrund des demografischen Wandels sowie Fortschritten in der[zum vollständigen Text gelangen Sie über die oben angegebene URL], 38. Jahrestagung der Deutschsprachigen Arbeitsgemeinschaft für Verbrennungsbehandlung (DAV 2020)

Published
2020
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16. Evaluation of a new robotic-assisted laparoscopic surgical system for procedures in small cavities

Author

Bergholz, R., Botden, S.M., Verweij, J., Tytgat, S., Gemert, W. Van, Boettcher, M., Ehlert, H., Reinshagen, K., Gidaro, S., Bergholz, R., Botden, S.M., Verweij, J., Tytgat, S., Gemert, W. Van, Boettcher, M., Ehlert, H., Reinshagen, K., and Gidaro, S.

Abstract

Item does not contain fulltext, No data exists concerning the application of a new robotic system with 3-mm instruments (Senhance™, Transenterix, Milano, Italy) in small cavities. Therefore, the aim of this study was to test the system for its performance of intracorporal suturing in small boxes simulating small body cavities. Translucent plastic boxes of decreasing volumes (2519-90 ml) were used. The procedures (two single stitches, each with two consecutive surgical square knots) were performed by a system-experienced and three system-inexperienced surgeons in each box, starting within the largest box, consecutively exchanging the boxes into smaller ones. With this approach, the total amount of procedures performed by each surgeon increased with decreasing volume of boxes being operated in. Outcomes included port placement, time, task completion, internal and external instrument/instrument collisions and instrument/box collisions. The procedures could be performed in all boxes. The operating time decreased gradually in the first three boxes (2519-853 ml), demonstrating a learning curve. The increase of operating time from boxes of 599 ml and lower may be attributed to the increased complexity of the procedure in small cavities as in the smallest box with the dimensions of 2.9 × 6.3 × 4.9 cm. This is also reflected by the parallel increase of internal instrument-instrument collisions. With the introduction of 3-mm instruments in a new robotic surgical system, we were able to perform intracorporal suturing and knot tying in cavities as small as 90 ml. Whether this system is comparable to conventional three-port 3-mm laparoscopic surgery in small cavities-such as in pediatric surgery-has to be evaluated in further studies.

Published
2020

19. Autophagocytosis of the apical membrane in microvillus inclusion disease. (Small Intestine)

Author

Reinshagen, K., Naim, H.Y., and Zimmer, K-P

Subjects
Medical research -- Analysis -- Case studies -- Methods -- Physiological aspects -- Health aspects, Medicine, Experimental -- Analysis -- Case studies -- Methods -- Physiological aspects -- Health aspects, Diarrhea in children -- Research -- Diagnosis -- Case studies -- Health aspects -- Physiological aspects -- Analysis -- Methods, Medical tests -- Analysis -- Case studies -- Methods -- Physiological aspects -- Health aspects, Biopsy -- Methods -- Case studies -- Physiological aspects -- Analysis -- Health aspects, Viral antibodies -- Physiological aspects -- Case studies -- Health aspects -- Methods -- Analysis, Patients -- Medical examination -- Health aspects -- Case studies -- Physiological aspects -- Methods -- Analysis, Antibodies -- Physiological aspects -- Case studies -- Health aspects -- Methods -- Analysis, Health, Diagnosis, Analysis, Physiological aspects, Medical examination, Case studies, Research, Methods, Health aspects
Abstract

Backgrounds: Microvillus inclusion disease (MID) is a disorder with the clinical signs of intractable diarrhoea in the newborn and infancy. The typical pathological features of the disease are well known [...]

Published
2002

30. Intestinal CD8+T cell responses are abundantly induced early in human development but show impaired cytotoxic effector capacities

Author

Schreurs, R. R. C.E., Sagebiel, A.F., Steinert, F.L., Highton, A.J., Klarenbeek, P.L., Drewniak, A., Bakx, R., The, S. M.L., Ribeiro, C. M.S., Perez, D., Reinshagen, K., Geijtenbeek, T. B.H., van Goudoever, J.B., and Bunders, M.J.

Abstract

Gastrointestinal viral infections are a major global cause of disease and mortality in infants. Cytotoxic CD8+T cells are critical to achieve viral control. However, studies investigating the development of CD8+T cell immunity in human tissues early in life are lacking. Here, we investigated the maturation of the CD8+T cell compartment in human fetal, infant and adult intestinal tissues. CD8+T cells exhibiting a memory phenotype were already detected in fetal intestines and increased after birth. Infant intestines preferentially harbored effector CCR7−CD45RA−CD127−KLRG1+/−CD8+T cells compared to tissue-resident memory CD69+CD103+CD8+T cells detected in adults. Functional cytotoxic capacity, including cytokine and granzyme B production of infant intestinal effector CD8+T cells was, however, markedly reduced compared to adult intestinal CD8+T cells. This was in line with the high expression of the inhibitory molecule PD-1 by infant intestinal effector CD8+T cells. Taken together, we demonstrate that intestinal CD8+T cell responses are induced early in human development, however exhibit a reduced functionality. The impaired CD8+T cell functionality early in life contributes to tolerance during foreign antigen exposure after birth, however functions as an immune correlate for the increased susceptibility to gastrointestinal viral infections in infancy.

Published
2021
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31. Mittelfristige Ergebnisse der Patienten mit Gallengangatresie nach Kasai-Operation- Faktorenanalysen für den Krankheitsverlauf

Author

Ridderbusch, I, Bergholz, R, Grabhorn, E, Fischer, L, and Reinshagen, K

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Ziel unserer Studie ist die Auswertung des Verlaufs aller Kinder mit Gallengangsatresie (GGA), die von 2009 bis 2015 in unserer Klinik eine Kasai-Operation und ggf. eine Lebertransplantation (LTX) im weiteren Verlauf erhalten haben. Analysiert wurden die den postoperativen Krankheitsverlauf[zum vollständigen Text gelangen Sie über die oben angegebene URL], 133. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2016
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33. IIioanale J-Pouch Anastomose bei Zuelzer Wilson Syndrom

Author

Staude, C, Boettcher, M, Kanellos-Becker, I, and Reinshagen, K

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Das Zuelzer Wilson Syndrom bezeichnet die Aganglionose, die den gesamten Kolonrahmen umfasst. Es tritt in 10% aller Patienten mit einer Aganglionose auf. Aufgrund der Länge des erkrankten Darms besteht die chirurgische Herausforderung eine gute Darmpassage mit erhaltener Kontinenz[for full text, please go to the a.m. URL], 132. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2015
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34. Fetoskopische abdominelle Dekompression der angeborenen Zwerchfellhernie – ein Schafmodell

Author

Bergholz, R, Fromm, F, Wenke, K, Krebs, T, Boettcher, M, Hecher, K, and Reinshagen, K

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die fetoskopische Trachealokklusion (FETO) gilt als aktueller Standard der pränatalen Behandlung einer schwergradigen angeborenen Zwerchfellhernie (CDH), ist aber nicht in der Lage den ursächlichen Schaden – den Druck des intrathorakalen Darmes auf die sich entwickelnde [for full text, please go to the a.m. URL], 132. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2015
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35. Einfluss von fetoskopischem / laparoskopischem Training auf die fetoskopische Performance

Author

Boettcher, M, Mietzsch, S, Romero, P, Bergholz, R, and Reinshagen, K

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Pränatale Eingriffe ermöglichen, wie u.a. die MoMS-Studie (Management of Myelomeningocele Study) gezeigt hat, großes Potential für die Behandlung von fetalen Anomalien, die immer häufiger und frühzeitiger erkannt werden. Insbesondere fetoskopische Eingriffe [for full text, please go to the a.m. URL], 132. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2015
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40. Ausgedehnte Fettgewebsnekrose nach Spülung einer peranalen Fistel bei Morbus Crohn im Kindesalter: Fournier'sche Gangrän oder OcteniseptR-Komplikation?

Author

Lange, B, Reinshagen, K, and Wessel, L

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die antiseptische Wundbehandlung ist auch im Kindesalter die Basis einer komplikationslosen Wundbehandlung. OcteniseptR ist aufgrund seines breiten antiseptischen Wirkspektrums ein häufig angewandtes Antiseptikum. Die schmerzfreie Anwendung von OcteniseptR favorisiert den Einsatz besonders[for full text, please go to the a.m. URL], 128. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2011

41. Nutzen-Risikoprofil von Kaudalanästhesie mit Morphinzusatz

Author

Gernoth, C, Bientzle, S, Thil, E, and Reinshagen, K

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die Kaudalanästhesie ist ein wesentliches Element der peri- und postoperativen Schmerztherapie bei Neugeborenen und Kleinkindern. Zur Optimierung von Wirkdauer und Intensität kann ohne Erhöhung von motorischen Blockaden neben Clonidin auch additiv Morphin verwendet werden.[for full text, please go to the a.m. URL], 127. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2010
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42. Einsatz eines Dermisersatzes (Matriderm ® ) bei thermischen Verletzungen der kindlichen Hand

Author

Königs, I, Zahn, K, Reinshagen, K, Göppl, M, and Wessel, LM

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Insbesondere im Kindesalter ist die vollständige Wiederherstellung der Funktion der Hand nach thermischer Verletzung ein entscheidendes Ziel der modernen Verbrennungsmedizin. Nach Transplantationen bei drittgradigen Verbrennungen kommt es oft zu einer ausgedehnten Narbenbildung mit [for full text, please go to the a.m. URL], 127. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2010
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