701 results on '"Reinheckel, Thomas"'
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2. Cathepsin D is essential for the degradomic shift of macrophages required to resolve liver fibrosis
3. Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders
4. Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and metastasis in breast cancer
5. Cathepsin D inhibition during neuronal differentiation selectively affects individual proteins instead of overall protein turnover
6. Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism
7. Differential regulation of progranulin derived granulin peptides
8. Dipeptidyl Peptidase 9 (DPP9) Depletion From Hepatocytes in Mice Retards Liver Tumour Growth and Increases Intrahepatic Caspase-1 Activation
9. Inhibition of cysteine protease cathepsin Lincreases the level and activity of lysosomal glucocerebrosidase
10. Tumor cell- and microenvironment-specific roles of cysteine cathepsins in mouse models of human cancers
11. Enhanced legumain activity links progranulin deficiency to TDP-43 pathology in frontotemporal lobar degeneration
12. The secreted inhibitor of invasive cell growth CREG1 is negatively regulated by cathepsin proteases
13. Cathepsin H deficiency decreases hypoxia-ischemia-induced hippocampal atrophy in neonatal mice through attenuated TLR3/IFN-β signaling
14. BRAFV600E drives dedifferentiation in small intestinal and colonic organoids and cooperates with mutant p53 and Apc loss in transformation
15. Early trypsin activation develops independently of autophagy in caerulein-induced pancreatitis in mice
16. Analyzing the Role of Proteases in Breast Cancer Progression and Metastasis Using Primary Cells from Transgenic Oncomice
17. Dipeptidyl-Aminopeptidases 8 and 9 Regulate Autophagy and Tamoxifen Response in Breast Cancer Cells
18. Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis
19. The role of proteases in epithelial-to-mesenchymal cell transitions in cancer
20. B-Raf deficiency impairs tumor initiation and progression in a murine breast cancer model
21. Cathepsin L in Secretory Vesicles Functions as a Prohormone-Processing Enzyme for Production of the Enkephalin Peptide Neurotransmitter
22. Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double deficient mice
23. Dilated Cardiomyopathy in Mice Deficient for the Lysosomal Cysteine Peptidase Cathepsin L
24. Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling
25. Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation
26. Poly-ADP Ribose Polymerase Activates Nuclear Proteasome to Degrade Oxidatively Damaged Histones
27. Cathepsin L is required for endothelial progenitor cell-induced neovascularization
28. Supplementary Figures 1-3 from Tumor Cell–Derived and Macrophage-Derived Cathepsin B Promotes Progression and Lung Metastasis of Mammary Cancer
29. Supplementary Methods from Tumor Cell–Derived and Macrophage-Derived Cathepsin B Promotes Progression and Lung Metastasis of Mammary Cancer
30. In Vivo Metabolic Imaging of [1-13C]Pyruvate-d3 Hyperpolarized By Reversible Exchange With Parahydrogen
31. In vivo‐Stoffwechselbildgebung mit [1‐13C]Pyruvat‐d3, hyperpolarisiert durch reversiblen Austausch mit Parawasserstoff.
32. In Vivo Metabolic Imaging of [1‐13C]Pyruvate‐d3 Hyperpolarized By Reversible Exchange With Parahydrogen**.
33. Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis
34. Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis
35. Exploring Systemic Functions of Lysosomal Proteases: The Perspective of Genetically Modified Mouse Models
36. Degradome-focused RNA interference screens to identify proteases important for breast cancer cell growth
37. Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism
38. CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients
39. Roles of Cysteine Proteases in Tumor Progression: Analysis of Cysteine Cathepsin Knockout Mice in Cancer Models
40. A new model system identifies epidermal growth factor receptor–human epidermal growth factor receptor 2 (HER2) and HER2–human epidermal growth factor receptor 3 heterodimers as potent inducers of oesophageal epithelial cell invasion
41. Specific functions of lysosomal proteases in endocytic and autophagic pathways
42. Low‐level lysosomal membrane permeabilization for limited release and sublethal functions of cathepsin proteases in the cytosol and nucleus
43. Tyrosine kinase inhibitors trigger lysosomal damage-associated cell lysis to activate the NLRP3 inflammasome
44. Additional file 1 of Differential regulation of progranulin derived granulin peptides
45. Synergistic Antitumor Effects of Combined Cathepsin B and Cathepsin Z Deficiencies on Breast Cancer Progression and Metastasis in Mice
46. Role of endogenous and exogenous antioxidants in the defence against functional damage and lipid peroxidation in rat liver mitochondria
47. RNA interference screens discover proteases as synthetic lethal partners of PI3K inhibition in breast cancer cells
48. Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis
49. Cathepsin L Inactivates Human Trypsinogen, Whereas Cathepsin L-Deletion Reduces the Severity of Pancreatitis in Mice
50. Cathepsin B-deficient mice as source of monoclonal anti-cathepsin B antibodies
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