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3. Latest observations on the low energy excess in CRESST-III

Author

G. Angloher, S. Banik, G. Benato, A. Bento, A. Bertolini, R. Breier, C. Bucci, L. Canonica, A. D'Addabbo, S. Di Lorenzo, L. Einfalt, A. Erb, F. von Feilitzsch, N. Ferreiro Iachellini, S. Fichtinger, D. Fuchs, A. Fuss, A. Garai, V. M. Ghete, S. Gerster, P. Gorla, P. V. Guillaumon, S. Gupta, D. Hauff, M. Ješkovský, J. Jochum, M. Kaznacheeva, A. Kinast, H. Kluck, H. Kraus, A. Langenkämper, M. Mancuso, L. Marini, L. Meyer, V. Mokina, A. Nilima, M. Olmi, T. Ortmann, C. Pagliarone, L. Pattavina, F. Petricca, W. Potzel, P. Povinec, F. Pröbst, F. Pucci, F. Reindl, J. Rothe, K. Schäffner, J. Schieck, D. Schmiedmayer, S. Schönert, C. Schwertner, M. Stahlberg, L. Stodolsky, C. Strandhagen, R. Strauss, I. Usherov, F. Wagner, M. Willers, V. Zema

Subjects
Physics, QC1-999
Abstract

The CRESST experiment observes an unexplained excess of events at low energies. In the current CRESST-III data-taking campaign we are operating detector modules with different designs to narrow down the possible explanations. In this work, we show first observations of the ongoing measurement, focusing on the comparison of time, energy and temperature dependence of the excess in several detectors. These exclude dark matter, radioactive backgrounds and intrinsic sources related to the crystal bulk as a major contribution.

Published
2023
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4. Characterisation of low background CaWO$_4$ crystals for CRESST-III

Author

A. Kinast, G. Angloher, S. Banik, G. Benato, A. Bento, A. Bertolini, R. Breier, C. Bucci, J. Burkhart, L. Canonica, A. D'Addabbo, S. Di Lorenzo, L. Einfalt, A. Erb, F. v. Feilitzsch, N. Ferreiro Iachellini, S. Fichtinger, D. Fuchs, A. Fuss, A. Garai, V.M. Ghete, S. Gerster, P. Gorla, P.V. Guillaumon, S. Gupta, D. Hauff, M. Ješkovský, J. Jochum, M. Kaznacheeva, H. Kluck, H. Kraus, A. Langenkämper, M. Mancuso, L. Marini, L. Meyer, V. Mokina, A. Nilima, M. Olmi, T. Ortmann, C. Pagliarone, L. Pattavina, F. Petricca, W. Potzel, P. Povinec, F. Pröbst, F. Pucci, F. Reindl, J. Rothe, K. Schäffner, J. Schieck, D. Schmiedmayer, S. Schönert, C. Schwertner, M. Stahlberg, L. Stodolsky, C. Strandhagen, R. Strauss, I. Usherov, F. Wagner, M. Willers, V. Zema (CRESST Collaboration)

Subjects
Physics, QC1-999
Abstract

The CRESST-III experiment aims at the direct detection of dark matter particles via their elastic scattering off nuclei in a scintillating CaWO$_4$ target crystal. For many years CaWO$_4$ crystals have successfully been produced in-house at Technische Universität München with a focus on high radiopurity. To further improve the CaWO$_4$ crystals, an extensive chemical purification of the raw materials has been performed and the crystal TUM93 was produced from this powder. We present results from an $\alpha$-decay rate analysis performed on 344 days of data collected in the ongoing CRESST-III data-taking campaign. The $\alpha$-decay rate could significantly be reduced.

Published
2023
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5. Enhanced RBE of Particle Radiation Depends on Beam Size in the Micrometer Range

Author

Ilicic, K., primary, Dollinger, G., additional, Dombrowsky, A., additional, Greubel, C., additional, Girst, S., additional, Sammer, M., additional, Siebenwirth, C., additional, Schmid, E., additional, Friedrich, T., additional, Kundrát, P., additional, Friedland, W., additional, Scholz, M., additional, Combs, S.E., additional, Schmid, T.E., additional, and Reindl, J., additional

Published
2024
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13. FLASH Modalities Track (Oral Presentations) NEW R&D PLATFORM WITH UNIQUE CAPABILITIES FOR ELECTRON FLASH AND VHEE RADIATION THERAPY AND RADIATION BIOLOGY UNDER PREPARATION AT PITZ

Author

Stephan, F., primary, Aboulbanine, Z., additional, Amirkhanyan, Z., additional, Good, J., additional, Gross, M., additional, Krasilnikov, M., additional, Lishilin, O., additional, Oppelt, A., additional, Philipp, S., additional, Qian, H., additional, Stegmann, C., additional, Worm, S., additional, Leemans, W., additional, Schmitz, M., additional, Schnautz, T., additional, Weise, H., additional, Budach, V., additional, Ehrhardt, V., additional, Vozenin, M.-C., additional, Faus-Golfe, A., additional, Tsakanova, G., additional, Schüller, A., additional, Frohme, M., additional, Grebinyk, A., additional, Reindl, J., additional, Grüner, F., additional, and Staufer, T., additional

Published
2022
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20. Exploring $$\hbox {CE}\nu \hbox {NS}$$ with NUCLEUS at the Chooz nuclear power plant

Author

G. Angloher, F. Ardellier-Desages, A. Bento, L. Canonica, A. Erhart, N. Ferreiro, M. Friedl, V. M. Ghete, D. Hauff, H. Kluck, A. Langenkämper, T. Lasserre, D. Lhuillier, A. Kinast, M. Mancuso, J. Molina Rubiales, E. Mondragón, G. Munch, C. Nones, L. Oberauer, A. Onillon, T. Ortmann, L. Pattavina, F. Petricca, W. Potzel, F. Pröbst, F. Reindl, J. Rothe, J. Schieck, S. Schönert, C. Schwertner, L.

Published
2019
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24. O061 - FLASH Modalities Track (Oral Presentations) NEW R&D PLATFORM WITH UNIQUE CAPABILITIES FOR ELECTRON FLASH AND VHEE RADIATION THERAPY AND RADIATION BIOLOGY UNDER PREPARATION AT PITZ

Author

Stephan, F., Aboulbanine, Z., Amirkhanyan, Z., Good, J., Gross, M., Krasilnikov, M., Lishilin, O., Oppelt, A., Philipp, S., Qian, H., Stegmann, C., Worm, S., Leemans, W., Schmitz, M., Schnautz, T., Weise, H., Budach, V., Ehrhardt, V., Vozenin, M.-C., Faus-Golfe, A., Tsakanova, G., Schüller, A., Frohme, M., Grebinyk, A., Reindl, J., Grüner, F., and Staufer, T.

Published
2022
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27. Das Werkzeugschleifen

Author

Reindl, J., Bussien, R., editor, Cochius, A., editor, Güldenstein, K., editor, Herbst, E., editor, Hippler, W., editor, Koch, R., editor, Mauck, H., editor, Reindl, J., editor, Schmitz, O., editor, Simon, E., editor, and Toussaint, E., editor

Published
1925
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28. Schleifen und Schleifscheiben

Author

Reindl, J., Bussien, R., editor, Cochius, A., editor, Güldenstein, K., editor, Herbst, E., editor, Hippler, W., editor, Koch, R., editor, Mauck, H., editor, Reindl, J., editor, Schmitz, O., editor, Simon, E., editor, and Toussaint, E., editor

Published
1925
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33. Improved normal tissue protection by proton and X-ray microchannels compared to homogeneous field irradiation

Author

Girst, S, Marx, C, Braeuer-Krisch, E, Bravin, A, Bartzsch, S, Oelfke, U, Greubel, C, Reindl, J, Siebenwirth, C, Zlobinskaya, O, Multhoff, G, Dollinger, G, Schmid, T, Wilkens, J, Girst S, Marx C, Braeuer-Krisch E, Bravin A, Bartzsch S, Oelfke U, Greubel C, Reindl J, Siebenwirth C, Zlobinskaya O, Multhoff G, Dollinger G, Schmid TE, Wilkens JJ, Girst, S, Marx, C, Braeuer-Krisch, E, Bravin, A, Bartzsch, S, Oelfke, U, Greubel, C, Reindl, J, Siebenwirth, C, Zlobinskaya, O, Multhoff, G, Dollinger, G, Schmid, T, Wilkens, J, Girst S, Marx C, Braeuer-Krisch E, Bravin A, Bartzsch S, Oelfke U, Greubel C, Reindl J, Siebenwirth C, Zlobinskaya O, Multhoff G, Dollinger G, Schmid TE, and Wilkens JJ

Abstract

The risk of developing normal tissue injuries often limits the radiation dose that can be applied to the tumour in radiation therapy. Microbeam Radiation Therapy (MRT), a spatially fractionated photon radiotherapy is currently tested at the European Synchrotron Radiation Facility (ESRF) to improve normal tissue protection. MRT utilizes an array of microscopically thin and nearly parallel X-ray beams that are generated by a synchrotron. At the ion microprobe SNAKE in Munich focused proton microbeams ("proton microchannels") are studied to improve normal tissue protection. Here, we comparatively investigate microbeam/microchannel irradiations with sub-millimetre X-ray versus proton beams to minimize the risk of normal tissue damage in a human skin model, in vitro. Skin tissues were irradiated with a mean dose of 2 Gy over the irradiated area either with parallel synchrotron-generated X-ray beams at the ESRF or with 20 MeV protons at SNAKE using four different irradiation modes: homogeneous field, parallel lines and microchannel applications using two different channel sizes. Normal tissue viability as determined in an MTT test was significantly higher after proton or X-ray microchannel irradiation compared to a homogeneous field irradiation. In line with these findings genetic damage, as determined by the measurement of micronuclei in keratinocytes, was significantly reduced after proton or X-ray microchannel compared to a homogeneous field irradiation. Our data show that skin irradiation using either X-ray or proton microchannels maintain a higher cell viability and DNA integrity compared to a homogeneous irradiation, and thus might improve normal tissue protection after radiation therapy.

Published
2015

39. Die Schneidwerkzeuge für den Austauschbau

Author

Reindl, J., Berndt, G., editor, Damm, Th., editor, Drescher, C. W., editor, Frenz, G., editor, Gohlke, M., editor, Gottwein, K., editor, Gramenz, K., editor, Huhn, E., editor, Kienzle, Otto, editor, Leifer, G., editor, and Reindl, I., editor

Published
1923
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42. MODELING STUDIES ON DICENTRICS INDUCTION AFTER SUB-MICROMETER FOCUSED ION BEAM GRID IRRADIATION.

Author

Friedland, W, Kundrát, P, Schmitt, E, Becker, J, Ilicic, K, Greubel, C, Reindl, J, Siebenwirth, C, Schmid, T E, and Dollinger, G

Subjects
ION beams, RADIATION damage, DOUBLE-strand DNA breaks, CHROMOSOME abnormalities, CENTROMERE
Abstract

The biophysical simulation tool PARTRAC contains modules for DNA damage response representing non-homologous end joining of DNA double-strand breaks (DSB) and the formation of chromosomal aberrations. Individual DNA ends from the induced DSB are followed regarding both their enzymatic processing and spatial mobility, as is needed for chromosome aberrations to arise via ligating broken ends from different chromosomes. In particular, by tracking the genomic locations of the ligated fragments and the positions of centromeres, the induction of dicentrics can be modeled. In recent experiments, the impact of spatial clustering of DNA damage on dicentric yields has been assessed in AL human-hamster hybrid cells: Defined numbers of 20 MeV protons (linear energy transfer, LET 2.6 keV/μm), 45 MeV Li ions (60 keV/μm) and 55 MeV C ions (310 keV/μm) focused to sub-μm spot sizes were applied with the ion microbeam SNAKE in diverse grid modes, keeping the absorbed dose constant. The impact of the μm-scaled spatial distribution of DSB (focusing effect) has thus been separated from nm-scaled DSB complexity (LET effect). The data provide a unique benchmark for the model calculations. Model and parameter refinements are described that enabled the simulations to largely reproduce both the LET-dependence and the focusing effect as well as the usual biphasic rejoining kinetics. The predictive power of the refined model has been benchmarked against dicentric yields for photon irradiation. [ABSTRACT FROM AUTHOR]

Published
2019
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45. Sub-micrometer 20 MeV protons or 45 MeV lithium spot irradiation enhances yields of dicentric chromosomes due to clustering of DNA double-strand breaks

Author

Schmid, T.E., primary, Friedland, W., additional, Greubel, C., additional, Girst, S., additional, Reindl, J., additional, Siebenwirth, C., additional, Ilicic, K., additional, Schmid, E., additional, Multhoff, G., additional, Schmitt, E., additional, Kundrát, P., additional, and Dollinger, G., additional

Published
2015
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