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2. Participation, retention and uptake in a multicentre pre-exposure prophylaxis cohort using online, smartphone-compatible data collection

Author

Hovaguimian, Frédérique; https://orcid.org/0000-0003-4181-2948, Martin, Eileen Christiane, Reinacher, M, Rasi, M, Schmidt, A J, Bernasconi, E, Boffi El Amari, E, Braun, D L, Calmy, A, Darling, K; https://orcid.org/0000-0003-1449-3873, Christinet, V, Depmeier, C, Hauser, C, Läuchli, S, Notter, J, Stoeckle, M, Surial, B, Vernazza, P, Bruggmann, P, Tarr, P, Haerry, D, Bize, R, Low, N, Lehner, A, Böni, J, Kouyos, R D, Fehr, J S, Hampel, B, Hovaguimian, Frédérique; https://orcid.org/0000-0003-4181-2948, Martin, Eileen Christiane, Reinacher, M, Rasi, M, Schmidt, A J, Bernasconi, E, Boffi El Amari, E, Braun, D L, Calmy, A, Darling, K; https://orcid.org/0000-0003-1449-3873, Christinet, V, Depmeier, C, Hauser, C, Läuchli, S, Notter, J, Stoeckle, M, Surial, B, Vernazza, P, Bruggmann, P, Tarr, P, Haerry, D, Bize, R, Low, N, Lehner, A, Böni, J, Kouyos, R D, Fehr, J S, and Hampel, B

Abstract

OBJECTIVES: The aim of the study was to assess the feasibility of a national pre-exposure prophylaxis (PrEP) programme using smartphone-compatible data collection. METHODS: This was a multicentre cohort study (NCT03893188) enrolling individuals interested in PrEP in Switzerland. All centres participate in the SwissPrEPared programme, which uses smartphone-compatible data collection. Feasibility was assessed after centres had enrolled at least one participant. Participants were HIV-negative individuals presenting for PrEP counselling. Outcomes were participation (number enrolled/number eligible), enrolment rates (number enrolled per month), retention at first follow-up (number with first follow-up/number enrolled), and uptake (proportion attending first visit as scheduled). Participant characteristics were compared between those retained after baseline assessment and those who dropped out. RESULTS: Between April 2019 and January 2020, 987 individuals were assessed for eligibility, of whom 969 were enrolled (participation: 98.2%). The median enrolment rate was 86 per month [interquartile range (IQR) 52-137]. Retention at first follow-up and uptake were both 80.7% (782/969 and 532/659, respectively). At enrolment, the median age was 40 (IQR 33-47) years, 95% were men who have sex with men, 47% had a university degree, and 75.5% were already taking PrEP. Most reported multiple casual partners (89.2%), previous sexually transmitted infections (74%) and sexualized drug use (73.1%). At baseline, 25.5% tested positive for either syphilis, gonorrhoea or chlamydia. Participants who dropped out were at lower risk of HIV infection than those retained after baseline assessment. CONCLUSIONS: In a national PrEP programme using smartphone-compatible data collection, participation, retention and uptake were high. Participants retained after baseline assessment were at considerable risk of HIV infection. Younger, less educated individuals were underrepresented in the SwissPrEPared co

Published
2022

5. Participation, retention and uptake in a multicentre pre‐exposure prophylaxis cohort using online, smartphone‐compatible data collection

Author

Hovaguimian, F, primary, Martin, E, additional, Reinacher, M, additional, Rasi, M, additional, Schmidt, AJ, additional, Bernasconi, E, additional, Boffi El Amari, E, additional, Braun, DL, additional, Calmy, A, additional, Darling, K, additional, Christinet, V, additional, Depmeier, C, additional, Hauser, C, additional, Läuchli, S, additional, Notter, J, additional, Stoeckle, M, additional, Surial, B, additional, Vernazza, P, additional, Bruggmann, P, additional, Tarr, P, additional, Haerry, D, additional, Bize, R, additional, Low, N, additional, Lehner, A, additional, Böni, J, additional, Kouyos, RD, additional, Fehr, JS, additional, and Hampel, B, additional

Published
2021
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10. Participation, retention and uptake in a multicentre pre‐exposure prophylaxis cohort using online, smartphone‐compatible data collection.

Author

Hovaguimian, F, Martin, E, Reinacher, M, Rasi, M, Schmidt, AJ, Bernasconi, E, Boffi El Amari, E, Braun, DL, Calmy, A, Darling, K, Christinet, V, Depmeier, C, Hauser, C, Läuchli, S, Notter, J, Stoeckle, M, Surial, B, Vernazza, P, Bruggmann, P, and Tarr, P

Subjects
HIV prevention, RESEARCH, PATIENT participation, SMARTPHONES, MEDICAL cooperation, AUTOMATIC data collection systems, PREVENTIVE medicine, LONGITUDINAL method
Abstract

Objectives: The aim of the study was to assess the feasibility of a national pre‐exposure prophylaxis (PrEP) programme using smartphone‐compatible data collection. Methods: This was a multicentre cohort study (NCT03893188) enrolling individuals interested in PrEP in Switzerland. All centres participate in the SwissPrEPared programme, which uses smartphone‐compatible data collection. Feasibility was assessed after centres had enrolled at least one participant. Participants were HIV‐negative individuals presenting for PrEP counselling. Outcomes were participation (number enrolled/number eligible), enrolment rates (number enrolled per month), retention at first follow‐up (number with first follow‐up/number enrolled), and uptake (proportion attending first visit as scheduled). Participant characteristics were compared between those retained after baseline assessment and those who dropped out. Results: Between April 2019 and January 2020, 987 individuals were assessed for eligibility, of whom 969 were enrolled (participation: 98.2%). The median enrolment rate was 86 per month [interquartile range (IQR) 52–137]. Retention at first follow‐up and uptake were both 80.7% (782/969 and 532/659, respectively). At enrolment, the median age was 40 (IQR 33–47) years, 95% were men who have sex with men, 47% had a university degree, and 75.5% were already taking PrEP. Most reported multiple casual partners (89.2%), previous sexually transmitted infections (74%) and sexualized drug use (73.1%). At baseline, 25.5% tested positive for either syphilis, gonorrhoea or chlamydia. Participants who dropped out were at lower risk of HIV infection than those retained after baseline assessment. Conclusions: In a national PrEP programme using smartphone‐compatible data collection, participation, retention and uptake were high. Participants retained after baseline assessment were at considerable risk of HIV infection. Younger, less educated individuals were underrepresented in the SwissPrEPared cohort. [ABSTRACT FROM AUTHOR]

Published
2022
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13. LIST OF CONTRIBUTORS

Author

Albini, B., primary, Adler, B., additional, Adler, H., additional, Ameratunga, R., additional, Anderson, A.O., additional, Andrews, A.E., additional, Arstila, T.P., additional, Bailey, M., additional, Barnes, H.J., additional, Bazin, H., additional, Bertoni, G., additional, Blacklaws, B., additional, Bos, N.A., additional, Brait, M., additional, Butler, J.E., additional, Cahill, R.N.P., additional, Carter, S.D., additional, Cesbron, J.-Y., additional, Charlemagne, J., additional, Charley, B., additional, Cunningham, C., additional, Cukrowska, B., additional, Daha, M.R., additional, Dammers, P.M., additional, Deenen, G.J., additional, Defresne, M.P., additional, Delhem, N., additional, Demaries, S.L., additional, Desmecht, D., additional, Dijkstra, C.D., additional, Ellis, A.E., additional, Fatzer, R., additional, Felsburg, P.J., additional, Fletcher, O.J., additional, Fluri, A., additional, Foss, D.L., additional, Gianello, P., additional, Giger, U., additional, Goddeeris, B., additional, Govaerts, A., additional, Grant, C.K., additional, Greiner, D.L., additional, Griebel, P.J., additional, Grimholt, U., additional, Groen, H., additional, Hague, B., additional, Haig, D., additional, Hala, K., additional, Hamers, R., additional, Hanken, R.J., additional, Hannant, D., additional, Harbour, D.A., additional, Harlan, J., additional, Hawken, R.J., additional, Hein, W.R., additional, Heinen, E., additional, Helfand, S.C., additional, Hermann, T., additional, Høgåsen, K., additional, Hogenesch, H., additional, Hordvik, I., additional, Horohov, D.W., additional, Howard, C., additional, Hünig, T., additional, Husband, A., additional, Hüttner, S.W., additional, Hylkema, M.N., additional, Ingram, G.A., additional, Ishiguro, N., additional, Jakowlew, S.B., additional, Jeurissen, S.H.M., additional, Joosten, E., additional, Jørgensen, T., additional, Jungi, T.W., additional, Kaplan, M.H., additional, Kaufman, J., additional, Kimpton, W.G., additional, Knight, K.L., additional, Koch, C., additional, Komatsu, M., additional, Koppenheffer, T.L., additional, Krakowka, G.S., additional, Kroese, F.G.M., additional, Landsverk, T., additional, Lanning, D., additional, Latinne, D., additional, Leblond, V., additional, Leutenegger, C., additional, Levy, J.K., additional, Lewin, H., additional, Lie, Ø., additional, Lillehoj, H.S., additional, Llanes, D., additional, Lumsden, J.S., additional, Lunn, D.P., additional, Lunney, J., additional, Lutz, H., additional, MacHugh, N., additional, Maddox, J.F., additional, Mage, R.G., additional, Martin, H.M., additional, McClure, S., additional, McConnell, T.J., additional, McCormack, W.T., additional, McCullagh, P.P., additional, McKeever, D., additional, Mertens, B., additional, Miller, N.W., additional, Modiano, J.F., additional, Morgan, B.P., additional, Morizot, D.C., additional, Moutschen, M.P., additional, Murtaugh, M.P., additional, Muyldermans, S., additional, Naessens, J., additional, Nash, A.D., additional, Nguyen, T.C., additional, Nieuwenhuis, P., additional, Obexer-Ruff, G., additional, Pabst, R., additional, Pastoret, P.P., additional, Pedersen, N.C., additional, Pertile, T.L., additional, Pescovitz, M.D., additional, Peterhans, E., additional, Pilstöm, L., additional, Plachy, J., additional, Press, C. McL., additional, Pu, R., additional, Ramamoorthy, C., additional, Ratcliffe, M.J.H., additional, Rautenschlein, S., additional, Reinacher, M., additional, Ritchey, J.W., additional, Robertsen, B., additional, Rodkey, L.S., additional, Rombout, J.H.W.M., additional, Roth, J., additional, Rothkötter, H.J., additional, Rozing, J., additional, Schat, K.A., additional, Seto, A., additional, Sharar, S., additional, Sharma, J.M., additional, Sinkora, J., additional, Sittisombut, N., additional, Soares, M., additional, Sopp, P., additional, Stokes, C.R., additional, Suter, M., additional, Tabel, H., additional, Tatner, M.F., additional, Tissot, R.G., additional, Tlaskalová-Hogenová, H., additional, Toivanen, P., additional, Tompkins, M.B., additional, Tompkins, W.A.F., additional, Torres-Nagel, N.E., additional, Tournefier, A., additional, Trebichavsky, I., additional, Tucker, E., additional, Urbain, J., additional, Vainio, O., additional, van den Berg, R.H., additional, van den Berg, T.K., additional, van den Broeke, A., additional, van der Meide, P., additional, Vandevelde, M., additional, van Rees, E.P., additional, Vögeli, P., additional, Wagner, J.L., additional, Wakenell, P.S., additional, Watson, D., additional, Weinstein, P.D., additional, Werner, E.R., additional, Westermann, J., additional, Whalen, B.J., additional, Willett, B.J., additional, Winkelstein, J.A., additional, Winn, R., additional, Yamamoto, J.K., additional, Young, A.J., additional, and Zurbriggen, A., additional

Published
1998
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25. Repetitive tactile stimulation changes resting-state functional connectivity—implications for treatment of sensorimotor decline

Author

Freyer, F., Reinacher, M., Nolte, G., hubert dinse, and Ritter, P.

Subjects
mu-rhythm, sensory stimulation, plasticity, functional connectivity, Original Research Article, EEG, resting state, ongoing activity, Neuroscience, sensorimotor
Abstract

Neurological disorders and physiological aging can lead to a decline of perceptual abilities. In contrast to the conventional therapeutic approach that comprises intensive training and practicing, passive repetitive sensory stimulation (RSS) has recently gained increasing attention as an alternative to countervail the sensory decline by improving perceptual abilities without the need of active participation. A particularly effective type of high-frequency RSS, utilizing Hebbian learning principles, improves perceptual acuity as well as sensorimotor functions and has been successfully applied to treat chronic stroke patients and elderly subjects. High-frequency RSS has been shown to induce plastic changes of somatosensory cortex such as representational map reorganization, but its impact on the brain's ongoing network activity and resting-state functional connectivity has not been investigated so far. Here, we applied high-frequency RSS in healthy human subjects and analyzed resting state Electroencephalography (EEG) functional connectivity patterns before and after RSS by means of imaginary coherency (ImCoh), a frequency-specific connectivity measure which is known to reduce over-estimation biases due to volume conduction and common reference. Thirty minutes of passive high-frequency RSS lead to significant ImCoh-changes of the resting state mu-rhythm in the individual upper alpha frequency band within distributed sensory and motor cortical areas. These stimulation induced distributed functional connectivity changes likely underlie the previously observed improvement in sensorimotor integration.

Published
2012
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27. Atlante di Patologia Suina

Author

Alborali, L, Guarda, F, Bollo, E, Pospischil, A, Reinacher, M, Plana, M A S, University of Zurich, Alborali, L, and Guarda, F

Subjects
570 Life sciences, biology, 10184 Institute of Veterinary Pathology
Published
2010
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28. Atlante di Patologia Suina A Volume I

Author

Alborali, L, Guarda, F, Biolatti, B, Pospischil, A, Reinacher, M, Sierra Plana, M A, University of Zurich, Alborali, L, and Guarda, F

Subjects
570 Life sciences, biology, 10184 Institute of Veterinary Pathology
Published
2009

33. High viral loads despite absence of clinical and pathological findings in cats experimentally infected with feline coronavirus (FCoV) type I and in naturally FCoV-infected cats

Author

Meli, Marina L, Kipar, Anja, Müller, C, Jenal, K, Gönczi, E, Borel, Nicole, Gunn-Moore, D, Chalmers, S, Lin, F, Reinacher, M, Lutz, H, University of Zurich, and Meli, Marina L

Subjects
10187 Department of Farm Animals, 3404 Small Animals, 570 Life sciences, biology, 10184 Institute of Veterinary Pathology
Published
2004
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35. Dominance of highly divergent feline leukemia virus A progeny variants in a cat with recurrent viremia and fatal lymphoma

Author

Helfer-Hungerbuehler, A K, Cattori, V, Boretti, Felicitas S; https://orcid.org/0000-0001-6793-8464, Ossent, Pete, Grest, Paula, Reinacher, M, Henrich, M, Bauer, E, Bauer-Pham, K, Niederer, E, Holznagel, E, Lutz, H, Hofmann-Lehmann, R; https://orcid.org/0000-0001-9750-4296, Helfer-Hungerbuehler, A K, Cattori, V, Boretti, Felicitas S; https://orcid.org/0000-0001-6793-8464, Ossent, Pete, Grest, Paula, Reinacher, M, Henrich, M, Bauer, E, Bauer-Pham, K, Niederer, E, Holznagel, E, Lutz, H, and Hofmann-Lehmann, R; https://orcid.org/0000-0001-9750-4296

Abstract

BACKGROUND: In a cat that had ostensibly recovered from feline leukemia virus (FeLV) infection, we observed the reappearance of the virus and the development of fatal lymphoma 8.5 years after the initial experimental exposure to FeLV-A/Glasgow-1. The goals of the present study were to investigate this FeLV reoccurrence and molecularly characterize the progeny viruses. RESULTS: The FeLV reoccurrence was detected by the presence of FeLV antigen and RNA in the blood and saliva. The cat was feline immunodeficiency virus positive and showed CD4+ T-cell depletion, severe leukopenia, anemia and a multicentric monoclonal B-cell lymphoma. FeLV-A, but not -B or -C, was detectable. Sequencing of the envelope gene revealed three FeLV variants that were highly divergent from the virus that was originally inoculated (89-91% identity to FeLV-A/Glasgow-1). In the long terminal repeat 31 point mutations, some previously described in cats with lymphomas, were detected. The FeLV variant tissue provirus and viral RNA loads were significantly higher than the FeLV-A/Glasgow-1 loads. Moreover, the variant loads were significantly higher in lymphoma positive compared to lymphoma negative tissues. An increase in the variant provirus blood load was observed at the time of FeLV reoccurrence. CONCLUSIONS: Our results demonstrate that ostensibly recovered FeLV provirus-positive cats may act as a source of infection following FeLV reactivation. The virus variants that had largely replaced the inoculation strain had unusually heavily mutated envelopes. The mutations may have led to increased viral fitness and/or changed the mutagenic characteristics of the virus.

Published
2010

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