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8. Dual-Source Computed Tomography

Author

Reimann, Anja J., primary, Rinck, Daniel, additional, Birinci-Aydogan, Ayser, additional, Scheuering, Michael, additional, Burgstahler, Christof, additional, Schroeder, Stephen, additional, Brodoefel, Harald, additional, Tsiflikas, Ilias, additional, Herberts, Tina, additional, Flohr, Thomas, additional, Claussen, Claus D., additional, Kopp, Andreas F., additional, and Heuschmid, Martin, additional

Published
2007
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10. Late enhancement using multidetector row computer tomography: a feasibility study with low dose 80 kV protocol.

Author

Reimann AJ, Kuettner A, Klumpp B, Heuschmid M, Schumacher F, Teufel M, Beck T, Burgstahler C, Schröder S, Claussen CD, Kopp AF, Reimann, Anja J, Kuettner, Axel, Klumpp, Bernhard, Heuschmid, Martin, Schumacher, Felix, Teufel, Matthias, Beck, Torsten, Burgstahler, Christof, and Schröder, Steffen

Abstract

Aims: Detecting stenoses of coronary arteries with multidetector row computer tomography (MDCT) is a well feasible non-invasive method. However, there is still the problem of deciding whether a stenosis is hemodynamically relevant or not. Objective of the present study was to validate the feasibility of a low dose protocol for MDCT using 80 kV for detecting late enhancement. Methods and Results: Using a Alderson-Rando Phantom evaluation of the effective dose of this LE protocol was performed. Ten patients (six male, four female, mean age 61) with known coronary artery disease and scheduled for a conventional coronary angiogram in our facility were subsequently recruited. All patients underwent CT-angiography (CTA) 1 day prior to magnetic resonance imaging. Five minutes after the application of 100ml contrast agent for the CTA scan, a low dose late enhancement scan (80 kV, 400 mA s maximum, ECG pulsed scan, 64 mm x 0.6mm collimation, 0.33 s tube rotation) was performed. Phantom dose measurements showed an effective dose for this protocol of 1.19 mSv (male) and 1.61 mSv (female). Fifty-six percent (5/9) of the patients showed a late enhancement on the MRI scan. Three transmural late enhancements and all four negative findings were correctly identified by CT. This represents a sensitivity of 78% (3/5), specificity of 100% (3/3), NPV of 100% (4/4) and a PPV of 97%. Conclusion: We were able to show that the low dose protocol is feasible and, furthermore, preliminary results look promising. [ABSTRACT FROM AUTHOR]

Published
2008
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