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Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders.

This paper describes our creative responses to a surface assemblage (a scatter) of lithic artefacts encountered on either side of a worn track across a field early on in the pandemic. Our art/archaeology response takes place within a phygital nexus in which artefacts or assemblages can be instantiated either physically or digitally, or both. In the nexus we create, connect and explore an ontological multiplicity of – more or less – physical and digital skeuomorphs and other more standard forms of records for sharing (i.e. Latour’s immutable mobiles, such as photographs), but rendered with radically different properties and affordances, at different scales, with different apparatus. These include interactive Reflectance Transformation Images, graphical surface models, machine intelligence style transfer, and 3D prints, all of which were produced in a variety of isolated analytical “bubble” settings and transmitted to and from (both digitally and physically) a home office in an isolated Hampshire village and a home studio in a London suburb. Our approach is to describe, diffractively, the ontological shifts and itineraries associated with some of these objects and assess how this assemblage came to matter as an art/archaeology installation. Ultimately, some of these deterritorialised, (re)colourised, affective, biodegradable, and diffractively born metamorphic instars, now inscribed with new meanings, are returned to the original findspot of the lithics to be (re)discovered.

In this art/archaeological study, we question the utility of the interrelated concepts of provenance, provenience, and paradata as applied to assemblages in art, archaeology, and cultural heritage contexts. We discuss how these overlapping concepts are used to establish values of authenticity and authoritative attributions. However, as cultural assemblages are increasingly being extended through virtualisation, they may exist digitally as well as physically, or as combinations of both, that is phygitally. We show how provenances and paradata can now become unstable and even detached from the assemblage. Through a sequence of collaborative projects, we expose two provenance illusions at the centre of archaeological recording and presentation practices. In these illusions, the archaeologists and much of the archaeology they record actually disappear from the authoritative reports that are published. Using a transdisciplinary, diffractive art/archaeology approach, these illusions are unpacked to reveal how superficially slight changes to traditional archaeological “drawings” and “photographs” have wrought fundamental ontological shifts in their modern phygital incarnations which undermines their provenances and associated paradata. We conclude that archaeology like fine art does not require conscious paradata in order to support statements of authority and interpretation. Instead, we argue that archaeologists should adopt an art/archaeology approach and subvert and dismantle established practices, methods, tools, techniques, and outputs. By highlighting and challenging inconsistencies in what we say we do with what we actually do, we expose gaps in our knowledge and data and shortcomings in our practices. These deficiencies can then be tackled by developing more robust (trans)disciplinary approaches.

The mental health of adolescents is a salient contemporary issue attracting the attention of policy makers in the UK and other countries. It is important that the roles and responsibilities of agencies are clearly established, particularly those positioned at the forefront of implementing change. Arguably, this will be more effective if those agencies are actively engaged in the development of relevant policy. An exploratory study was conducted with 10 focus groups including 54 adolescents, 8 mental health practitioners and 16 educational professionals. Thematic analysis revealed four themes: (1) mental health promotion and prevention is not perceived to be a primary role of a teacher; (2) teachers have limited skills to manage complex mental health difficulties; (3) adolescents rely on teachers for mental health support and education about mental health; and (4) the responsibility of parents for their children's mental health. The research endorses the perspective that teachers can support and begin to tackle mental well-being in adolescents. However, it also recognises that mental health difficulties can be complex, requiring adequate funding and support beyond school. Without this support in place, teachers are vulnerable and can feel unsupported, lacking in skills and resources which in turn may present a threat to their own mental well-being.

Fisheries are integrated social-­‐ecological systems, characterized by dynamic and complex interactions within and between the natural and human environments. California’s 1998 Marine Management Life Act (MLMA) recognizes the role of people in fisheries, and the MLMA Master Plan calls for the inclusion of socioeconomic as well as ecological “essential fishery information” in fishery management plans. However, critical gaps in such information for virtually all fisheries hinder managers’ ability to actively adapt and communities’ ability to plan for the future. This project begins to meet such information needs for the commercial fishery for California halibut, providing an example for other fisheries. We conducted a small collaborative fisheries research (CFR) project that engaged fishery participants, scientists and managers. Our goal was to produce sound social scientific understanding of the human dimensions of the fisheries system that is useful to the fishing, management, and scientific communities. We used an iterative approach, integrating analyses of data from the state’s California Fisheries Information System (CFIS), the literature, and knowledgeable fishery participants, managers and scientists to build understanding about the fishery’s human system and its dynamics. The research focused on the period 2000-­‐2012 to capture recent changes in the fishery and the larger fishery system, with events prior to and since also informing our efforts.

West Nile virus (WNV), the causative agent of West Nile fever (WNF), is an arbovirus of the genus Flavivirus, family Flaviviridae. WNV has been reported in a variety of species [...]