22 results on '"Reiko Hatori"'
Search Results
2. Whipple disease mimicking inflammatory bowel disease
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Maiko Tatsuki, Takashi Ishige, Yoshiko Igarashi, Reiko Hatori, Akira Hokama, Junko Hirato, Aleixo Muise, Takumi Takizawa, and Hirokazu Arakawa
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colitis, ulcerative ,child, preschool ,Medicine ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Whipple disease is a systemic chronic infection caused by Tropheryma whipplei. Although chronic diarrhea is a common gastrointestinal symptom, diagnosis is often difficult because there are no specific endoscopic findings, and the pathogen is not detectable by stool culture. We present a female patient with Whipple disease who developed chronic bloody diarrhea and growth retardation at the age of 4 years. Colonoscopy showed a mildly edematous terminal ileum and marked erythema without vascular patterns throughout the sigmoid colon and rectum. Subsequently, a primary diagnosis of ulcerative colitis was made. Histopathological analysis of the terminal ileum showed the presence of foamy macrophages filled with periodic acid-Schiff-positive particles. Polymerase chain reaction using DNA from a terminal ileum biopsy sample amplified a fragment of 16S rRNA from T. whipplei. Antibiotic treatment relieved the patient’s symptoms. There was no evidence of immunodeficiency in the present case. Since Whipple disease worsens after anti-tumor necrosis factor inhibitor therapy, considering this infection in the differential diagnosis may be important in patients with inflammatory bowel disease, especially before initiation of immunotherapy.
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- 2021
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3. Interleukin 2 receptor-α expression after lymphocyte stimulation for non-IgE-mediated gastrointestinal food allergies
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Hisako Yagi, Takumi Takizawa, Koichiro Sato, Takaharu Inoue, Yutaka Nishida, Satoshi Yamada, Takashi Ishige, Reiko Hatori, Takahiro Inoue, Yoshiyuki Yamada, and Hirokazu Arakawa
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Immunologic diseases. Allergy ,RC581-607 - Published
- 2020
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4. Severity scales of non-IgE-mediated gastrointestinal food allergies in neonates and infants
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Hisako Yagi, Takumi Takizawa, Koichiro Sato, Takaharu Inoue, Yutaka Nishida, Takashi Ishige, Maiko Tatsuki, Reiko Hatori, Yasuko Kobayashi, Yoshiyuki Yamada, and Hirokazu Arakawa
- Subjects
Immunologic diseases. Allergy ,RC581-607 - Abstract
Background: Non-IgE-mediated gastrointestinal food allergies (non-IgE-GI-FAs) are one type of food allergy found in neonates and infants. Few reports have defined the severity of non-IgE-GI-FAs in these populations. Methods: Grading scales of the severity of non-IgE-GI-FAs according to extra-GI symptoms, such as poor weight gain, as well as systemic symptoms, including fever and shock, were developed and retrospectively applied to patients with non-IgE-GI-FAs. The relationship between the severity of non-IgE-GI-FAs and both clinical and laboratory findings were examined. Results: Elevation of C-reactive protein levels and a decrease in total protein and albumin were observed in accordance with allergy severity. In an endoscopic examination, inflammatory findings were confirmed in large areas of the colonic mucosa in case of higher severity levels, and infiltration of inflammatory cells other than eosinophils was found in the severest grade. Extensively hydrolyzed milk or amino acid-based milk was required for all patients with the severest grade. In addition, the timing of acquiring tolerance tended to be late for this grade. Conclusions: Classification and determination of the severity of non-IgE-GI-FAs in neonates and infants may not only contribute to elucidation of the pathogenesis but may also be useful in the clinical setting. Keywords: Food hypersensitivity, Gastroenteritis, Infant, Milk, Prognosis
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- 2019
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5. Efficacy and Safety of Long-Term Administration of Esomeprazole in Japanese Pediatric Patients Aged 1-14 Years with Chronic Gastric Acid-Related Disease.
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Masaaki Mori, Yoshiko Nakayama, Shigeo Nishimata, Tadafumi Yokoyama, Ryo Matsuoka, Reiko Hatori, Masaki Shimizu, Katsuhiro Arai, Yuri Etani, Tsuyoshi Sogo, Tomoko Ishizu, Masahiro Nii, Ryosuke Nakashima, and Toshiaki Shimizu
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CHILD patients ,GASTRIC diseases ,ESOMEPRAZOLE ,GASTROESOPHAGEAL reflux ,DUODENAL ulcers ,ANTI-inflammatory agents - Abstract
Purpose: To evaluate prolonged esomeprazole use in Japanese pediatric patients for reflux esophagitis (RE) maintenance therapy and prevention of gastric (GU) and/or duodenal ulcers (DU) while using non-steroidal anti-inflammatory drugs (NSAIDs) or low-dose aspirin (LDA). Methods: This multicenter, open-label, parallel-group, phase III study (NCT03553563) included patients who were administered esomeprazole according to body weight (10 mg/day [Groups 1 and 3] and up to 20 mg/day [Groups 2 and 4] for patients weighing 10-20 kg and ≥20 kg, respectively). Efficacy outcomes for Groups 1 and 2 (maintenance therapy for healed RE) and Groups 3 and 4 (prevention of long-term NSAID/LDA use-associated GU/DU) were the presence/absence of RE relapse and GU/DU recurrence, respectively. Results: Esomeprazole as maintenance therapy was associated with a low RE recurrence rate, independent of body weight or dosage. Recurrence rates of RE were 0.0% and 5.3% for Groups 1 and 2, respectively. In patients previously diagnosed with GU and/or DU due to long-term NSAID/LDA use, the recurrence rates of GU/DU during weeks 0-32 were 11.1% and 0.0% in Groups 3 and 4, respectively. Conclusion: Long-term use of 10- or 20-mg, once-daily esomeprazole demonstrated a favorable benefit-risk balance in preventing RE and suppressing recurrence of GU and/or DU secondary to NSAID or LDA therapy in Japanese pediatric patients. No new safety concerns were identified. Esomeprazole may be a viable option for managing RE and preventing GU and DU in Japanese pediatric patients. [ABSTRACT FROM AUTHOR]
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- 2024
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6. The role of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein in the assessment of fibrosis in children with chronic hepatitis C
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Yoshinori Ito, Reiko Hatori, Yoko Miyoshi, Tomoko Takano, Hitoshi Tajiri, Stephen Brooks, Kazuhiko Bessho, Mitsuyoshi Suzuki, and Jun Murakami
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Liver Cirrhosis ,Receptors, N-Acetylglucosamine ,Membrane Glycoproteins ,Multidisciplinary ,business.industry ,Hepatitis C, Chronic ,medicine.disease ,Chronic hepatitis ,Fibrosis ,Immunology ,medicine ,Humans ,Plant Lectins ,Mac 2 binding protein ,Wisteria floribunda agglutinin ,business ,Child - Abstract
BackgroundAt present non-invasive fibrosis markers are not available for assessment of liver fibrosis in children with chronic hepatitis C. MethodsSixty-three children with chronic hepatitis C were included. Changes in Wisteria floribunda agglutinin-positive Mac-2 binding protein (M2BPGi) levels were evaluated in l3 of 27 treatment-naive patients during the observation period of the natural course of disease (median 4, range 3-6 years). Changes during treatment were evaluated in 27 of 36 patients for 4 (2-9) years of post-treatment follow-up. ResultsThere were significant differences in the levels of M2BPGi between the control group and HCV F0 group (P=0.002) and between the control group and HCV F1 group (PConclusionsOur study shows new findings that M2BPGi may be useful to predict the presence of a mild degree of fibrosis in children with chronic hepatitis C and such a mild fibrosis may be quickly resolved by antiviral therapies.
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- 2022
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7. Interleukin 2 receptor-α expression after lymphocyte stimulation for non-IgE-mediated gastrointestinal food allergies
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Koichiro Sato, Takahiro Inoue, Yutaka Nishida, Hisako Yagi, Satoshi Yamada, Takumi Takizawa, Hirokazu Arakawa, Yoshiyuki Yamada, Takaharu Inoue, Reiko Hatori, and Takashi Ishige
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lcsh:Immunologic diseases. Allergy ,Male ,Interleukin 2 ,Allergy ,Immunologic Tests ,Lymphocyte Activation ,Immunoglobulin E ,Ige mediated ,Humans ,Immunology and Allergy ,Medicine ,RNA, Messenger ,Child ,Receptor ,biology ,business.industry ,Infant, Newborn ,Interleukin-2 Receptor alpha Subunit ,Infant ,RNA ,General Medicine ,Allergens ,Milk Proteins ,medicine.disease ,Gastrointestinal Tract ,Child, Preschool ,Immunology ,biology.protein ,Female ,lcsh:RC581-607 ,Lymphocyte stimulation ,business ,Food Hypersensitivity ,medicine.drug - Published
- 2020
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8. Standard protocol devised by the Japanese Pediatric Impedance Working Group for combined multichannel intraluminal impedance-pH measurements in children
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Junko Fujino, Takanori Oyama, Suguru Fukahori, Takeshi Saito, Minoru Yagi, Takuo Noda, Aya Tanaka, Reiko Hatori, Hisayoshi Kawahara, and Ryuichi Shimono
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Protocol (science) ,Pediatrics ,medicine.medical_specialty ,business.industry ,urogenital system ,MEDLINE ,General Medicine ,Review Article ,Ph measurement ,Gastroesophageal reflux ,Multichannel intraluminal impedance-pH measurements ,embryonic structures ,Standard protocol ,Medicine ,Surgery ,business ,Children ,reproductive and urinary physiology - Abstract
Multichannel intraluminal impedance-pH measurements (MII-pH) are useful for evaluating acid and non-acid gastroesophageal reflux (GER). However, the use of MIH-pH is not yet established in Japan. The Japanese Pediatric Impedance Working Group (Japanese-PIG) convened to devise a standard protocol for MII-pH in Japanese children. The expert members of the Japanese-PIG collected data on pediatric MII-pH from the relevant literature in English, including the standard protocol of MII-pH presented by the European PIG, and the insights of international experts. The resultant consensus was included in the contents of the standard protocol of MII-pH. The standard protocol included standardization of the indication, methodology, and interpretation of MII-pH in Japanese children. The criteria for abnormal GER by MII-pH were defined using the Reflux Index and number of total reflux episodes independently in children aged
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- 2019
9. Serological cytokine signature in paediatric patients with inflammatory bowel disease impacts diagnosis
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Takeshi Tomomasa, Takumi Takizawa, Tomoko Nakazawa, Reiko Hatori, Seiichi Kagimoto, Takashi Ishige, Hirokazu Arakawa, Tomoko Hara, and Maiko Tatsuki
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Male ,Vascular Endothelial Growth Factor A ,0301 basic medicine ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Immunology ,lcsh:Medicine ,Disease ,Severity of Illness Index ,Inflammatory bowel disease ,Gastroenterology ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Child ,lcsh:Science ,Multidisciplinary ,business.industry ,Interleukins ,lcsh:R ,Area under the curve ,Interleukin ,Inflammatory Bowel Diseases ,medicine.disease ,Ulcerative colitis ,Vascular endothelial growth factor ,030104 developmental biology ,Cytokine ,chemistry ,Cytokines ,Biomarker (medicine) ,Female ,lcsh:Q ,business ,Biomarkers ,030217 neurology & neurosurgery - Abstract
Endoscopy is a central tool for diagnosing and evaluating paediatric inflammatory bowel diseases (PIBD), but is too invasive to be frequently repeated in young children. Furthermore, it is challenging to distinguish Crohn’s disease (CD) from ulcerative colitis (UC) endoscopically. This study aimed to determine biomarkers useful for the diagnosis of PIBD. Cytokines, chemokines, and growth factors were quantified in the sera of 15 patients with CD or UC, at disease onset prior to treatment, and 26 age-matched controls. Correlation of cytokine levels with the paediatric CD activity index (PCDAI) and the paediatric UC activity index (PUCAI) was analysed. Interleukin (IL)-6, IL-13, IL-7, and vascular endothelial growth factor were higher in the CD group than in the UC group. The receiver operating characteristic curve analysis showed that IL-7 was a putative biomarker for distinguishing CD from UC (area under the curve: 0.94). Granulocyte–macrophage colony-stimulating factor was associated with PCDAI, and an IL-1 receptor antagonist, IL-6, and macrophage inflammatory protein-1β were associated with PUCAI. These findings indicate significant differences in cytokine signatures among patients with new-onset PIBD, which may improve accuracy in diagnosing PIBD.
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- 2020
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10. An Initiative to deal with Gender-Equal Society in Gunma University
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Reiko Hatori, Yasuki Ishizaki, and Keiko Kowase
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Gender equality ,Gender studies ,General Medicine ,Sociology - Published
- 2018
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11. Temporal Trend of Pediatric Inflammatory Bowel Disease: Analysis of National Registry Data 2004 to 2013 in Japan
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Takeshi Tomomasa, Takashi Ishige, Yoshiko Igarashi, Maiko Tatsuki, Hirokazu Arakawa, Kazuhiko Sekine, and Reiko Hatori
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Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Inflammatory bowel disease ,Young Adult ,03 medical and health sciences ,Age Distribution ,0302 clinical medicine ,Japan ,Prevalence ,medicine ,Asian country ,Humans ,Registries ,Young adult ,Child ,Crohn disease ,business.industry ,Incidence (epidemiology) ,Infant, Newborn ,Gastroenterology ,Infant ,Inflammatory Bowel Diseases ,medicine.disease ,Ulcerative colitis ,Child, Preschool ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health ,Female ,030211 gastroenterology & hepatology ,National registry ,business - Abstract
Increased incidence and prevalence of pediatric inflammatory bowel disease (IBD) have been reported in Western countries. Changes in the prevalence of pediatric IBD in Asian countries, however, remain unclear. We evaluated the changes in the prevalence of IBD among Japanese adults and children from 2004 to 2013, by using the Japanese national registry data of patients receiving financial aid. Data from children (ages 0-19 years) were compared with those from young adults (ages 20-39 years). In 2004, age-standardized prevalences of Crohn disease (CD) and ulcerative colitis (UC) among children were 4.2 of 100,000 and 11.0 of 100,000, respectively. The corresponding prevalences among young adults were 41.0 of 100,000 and 89.8 of 100,000, respectively. In 2013, age-standardized prevalences of pediatric CD and UC were 7.2 of 100,000 and 15.0 of 100,000, respectively. During this period, prevalence of pediatric CD increased by 73.8% among children and by 49.0% in young adults. The prevalence of UC increased by 45.0% among children, and by 73.7% among young adults.
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- 2017
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12. IL-10RA Mutation as a Risk Factor of Severe Influenza-Associated Encephalopathy: A Case Report
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Yoshiko Igarashi, Takumi Takizawa, Hirokazu Arakawa, Takashi Ishige, Reiko Hatori, Yoji Sasahara, and Maiko Tatsuki
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0301 basic medicine ,Eotaxin ,medicine.medical_specialty ,medicine.drug_class ,business.industry ,medicine.medical_treatment ,Antibiotics ,Encephalopathy ,medicine.disease ,medicine.disease_cause ,Gastroenterology ,03 medical and health sciences ,Interleukin 10 ,030104 developmental biology ,Cytokine ,Internal medicine ,Pediatrics, Perinatology and Child Health ,medicine ,Influenza A virus ,Risk factor ,business ,Encephalitis - Abstract
Influenza-associated encephalitis and encephalopathy (IAE) is a severe complication of influenza infection with high morbidity and mortality. We present the case of a patient with IL-10RA mutation who developed encephalopathy after influenza infection. A 10-day-old boy developed recurrent fever and anal fistula. Growth failure gradually became apparent. He had been treated with antibiotics and elemental nutrition. However, the patient did not respond to the treatments. At 11 months, he suddenly developed shock with encephalopathy and multiple organ failures. He was then diagnosed with IAE. A cytokine study revealed elevated levels of IL-1 receptor antagonist, IL-2, IL-6, IL-8, IP-10, eotaxin, G-CSF, MCP-1, and IL-10. These cytokines are normally downregulated by IL-10. Genetic testing revealed a IL-10RA mutation at the 3′ end of exon 4 (c.537G→A). These findings might reflect an increased risk of severe IAE in patients with IL-10RA mutation.
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- 2018
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13. Severity scales of non-IgE-mediated gastrointestinal food allergies in neonates and infants
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Takaharu Inoue, Takumi Takizawa, Takashi Ishige, Yutaka Nishida, Yasuko Kobayashi, Reiko Hatori, Hisako Yagi, Hirokazu Arakawa, Koichiro Sato, Maiko Tatsuki, and Yoshiyuki Yamada
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lcsh:Immunologic diseases. Allergy ,0301 basic medicine ,Male ,medicine.medical_specialty ,Allergy ,Colon ,Poor weight gain ,Gastroenterology ,Severity of Illness Index ,Allergy Severity ,Pathogenesis ,03 medical and health sciences ,0302 clinical medicine ,Ige mediated ,Food allergy ,Internal medicine ,medicine ,Immunology and Allergy ,Humans ,Intestinal Mucosa ,Total protein ,business.industry ,Albumin ,Infant, Newborn ,Infant ,Endoscopy ,General Medicine ,Immunoglobulin E ,medicine.disease ,030104 developmental biology ,C-Reactive Protein ,030228 respiratory system ,Female ,lcsh:RC581-607 ,business ,human activities ,Food Hypersensitivity - Abstract
Background: Non-IgE-mediated gastrointestinal food allergies (non-IgE-GI-FAs) are one type of food allergy found in neonates and infants. Few reports have defined the severity of non-IgE-GI-FAs in these populations. Methods: Grading scales of the severity of non-IgE-GI-FAs according to extra-GI symptoms, such as poor weight gain, as well as systemic symptoms, including fever and shock, were developed and retrospectively applied to patients with non-IgE-GI-FAs. The relationship between the severity of non-IgE-GI-FAs and both clinical and laboratory findings were examined. Results: Elevation of C-reactive protein levels and a decrease in total protein and albumin were observed in accordance with allergy severity. In an endoscopic examination, inflammatory findings were confirmed in large areas of the colonic mucosa in case of higher severity levels, and infiltration of inflammatory cells other than eosinophils was found in the severest grade. Extensively hydrolyzed milk or amino acid-based milk was required for all patients with the severest grade. In addition, the timing of acquiring tolerance tended to be late for this grade. Conclusions: Classification and determination of the severity of non-IgE-GI-FAs in neonates and infants may not only contribute to elucidation of the pathogenesis but may also be useful in the clinical setting. Keywords: Food hypersensitivity, Gastroenteritis, Infant, Milk, Prognosis
- Published
- 2018
14. Fecal retention in childhood: Evaluation on ultrasonography
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Hirokazu Arakawa, Maiko Tatsuki, Reiko Hatori, Takeshi Tomomasa, and Takashi Ishige
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Male ,medicine.medical_specialty ,Constipation ,Adolescent ,Symphysis ,Ischial spine ,Physical examination ,Fecal Impaction ,Gastroenterology ,Sensitivity and Specificity ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Internal medicine ,medicine ,Humans ,Child ,Digital Rectal Examination ,Ultrasonography ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Infant, Newborn ,Rectum ,Infant ,Rectal examination ,medicine.disease ,Neck of urinary bladder ,medicine.anatomical_structure ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Functional constipation ,030211 gastroenterology & hepatology ,Female ,medicine.symptom ,business ,Nuclear medicine - Abstract
Background To assess the usefulness of rectal diameter measurement via ultrasonography as a diagnostic tool for fecal retention in children. Methods One hundred children (median age: 5.0 years), consisting of 80 with functional constipation and 20 without constipation, participated in the study. All patients underwent physical examination that included digital rectal examination. Forty-five children underwent ultrasonography in three differential planes: transection above the symphysis, under the ischial spine, and at the bladder neck. The measurement of the rectal diameter at the transection above the symphysis could most easily detect fecal retention and demonstrated the closest correlations with retention among the three planes. Results Rectal diameter was greater at all measuring points (35.2 vs. 20.9 mm above the symphysis, P < 0.0001; 35.7 vs. 24.0 mm under the ischial spine, P < 0.0001; and 19.4 vs. 8.7 mm at the bladder neck, P < 0.0001) in children with fecal retention than in those with no fecal retention. Comparing between children with functional constipation and those without constipation, children with fecal retention had a greater rectal diameter above the symphysis than in those with no fecal retention (children with functional constipation: 35.3 vs. 20.0 mm, P < 0.0001; children without constipation: 32.6 vs. 14.6 mm, P = 0.0026). The cutoff value for the rectal diameter measured above the symphysis to identify fecal retention was 27 mm, with high sensitivity and specificity (95.5% and 94.1%, respectively). Conclusion Ultrasound rectal diameter measurement can be used to detect fecal retention in children. This article is protected by copyright. All rights reserved.
- Published
- 2015
15. In vivo recording of colonic motility in conscious rats with deficiency of interstitial cells of Cajal, with special reference to the effects of nitric oxide on colonic motility
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Takeshi Tomomasa, Hiroaki Kaneko, Suzuki Makoto, Atsushi Takahashi, Takashi Ishige, Hiroyuki Kuwano, Reiko Hatori, Akihiro Morikawa, and Erito Mochiki
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Male ,Pathology ,medicine.medical_specialty ,Arginine ,Nitric Oxide ,Nitric oxide ,Colon, Ascending ,chemistry.chemical_compound ,symbols.namesake ,Colon, Sigmoid ,In vivo ,medicine ,Animals ,Chemistry ,Gastroenterology ,Rats, Inbred Strains ,digestive system diseases ,Rats ,Interstitial cell of Cajal ,Proto-Oncogene Proteins c-kit ,NG-Nitroarginine Methyl Ester ,symbols ,Nitric Oxide Synthase ,Gastrointestinal Motility ,Colonic motility ,Muscle Contraction - Abstract
We recorded in vivo colonic motility in rats with a deficiency of interstitial cells of Cajal (ICC) (Ws/Ws rats) and in wild-type rats (+/+ rats), with special reference to the effects of nitric oxide (NO) on colonic motility in both types of rats, in order to ascertain the role of ICC in colonic motility, and the relationship between NO and ICC in regard to colonic motility.Miniature strain-gauge force transducers were sutured on the surface of the ascending and sigmoid colon of Ws/Ws rats and +/+ rats as controls. After 1 week and a fasting period of 24 h, colonic motility in +/+ and Ws/Ws rats was recorded. We also studied the effect of NO on colonic motility in both types of rats, by means of the administration of N-nitro-L-arginine methyl ester (L-NAME) or L-arginine.In +/+ rats, there were contractions with high amplitude and long duration in both the ascending and sigmoid colon. The number, amplitude, and duration of contractions in the ascending colon were 9.9/20 min, 6.1 g, and 22.7 s, respectively. These findings in the sigmoid colon were 5.2/20 min, 5.2 g, and 23.0 s, respectively. The number of contractions in the ascending and sigmoid colon in Ws/Ws rats (2.3 and 1.0/20 min) was significantly lower than that in +/+ rats (P0.05). The number of contractions in the ascending and sigmoid colon in +/+ rats (9.7 and 5.1/20 min before treatment) was significantly increased by L-NAME administration (28.7 and 13.9/40-60 min after treatment; P0.05), but that in Ws/Ws rats was not influenced. The number of contractions in the ascending and sigmoid colon in +/+ rats (10.2 and 5.2/20 min before treatment) was significantly decreased by L-arginine administration (3.6 and 2.1/40-60 min after treatment; P0.05), but that in Ws/Ws rats was not influenced.ICC must be related to the occurrence of a normal number of colonic contractions. NO may be involved in the inhibitory regulation of colonic motility, and the effect of NO on the occurrence of contractions appears to be mediated by ICC.
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- 2005
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16. Endoscopic findings in the acute phase of food protein-induced enterocolitis syndromae
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Reiko Hatori, Yutaka Nishida, Hisako Yagi, Hirokazu Arakawa, Takashi Ishige, Maiko Tatsuki, and Takumi Takizawa
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Enterocolitis ,medicine.medical_specialty ,business.industry ,Food protein ,Internal medicine ,Phase (matter) ,Immunology ,Pediatrics, Perinatology and Child Health ,Immunology and Allergy ,Medicine ,medicine.symptom ,business ,Gastroenterology - Published
- 2015
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17. IL-10RA Mutation as a Risk Factor of Severe Influenza-Associated Encephalopathy: A Case Report.
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Takashi Ishige, Yoshiko Igarashi, Reiko Hatori, Maiko Tatsuki, Yoji Sasahara, Takumi Takizawa, and Hirokazu Arakawa
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- 2018
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18. Mo1776 Final Adult Height of Patients With Pediatric Onset Inflammatory Bowel Disease in Japan
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Maiko Tatsuki, Reiko Hatori, Hirokazu Arakawa, Takeshi Tomomasa, and Takashi Ishige
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medicine.medical_specialty ,Pediatrics ,Hepatology ,business.industry ,Pediatric onset ,Internal medicine ,Gastroenterology ,Medicine ,business ,medicine.disease ,Inflammatory bowel disease ,Adult height - Published
- 2016
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19. The effects of intestinal ischemia on colonic motility in conscious rats
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Suzuki Makoto, Akihiro Morikawa, Atsushi Takahashi, Reiko Hatori, Hiroyuki Kuwano, Takeshi Tomomasa, and Fumiaki Toki
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Male ,medicine.medical_specialty ,Consciousness ,Colon ,Ischemia ,Gastroenterology ,Nitric oxide ,symbols.namesake ,chemistry.chemical_compound ,Ileus ,Postoperative Complications ,In vivo ,Internal medicine ,medicine ,Animals ,Enzyme Inhibitors ,Rats, Wistar ,business.industry ,Intestinal ischemia ,Hepatology ,medicine.disease ,digestive system diseases ,Interstitial cell of Cajal ,Rats ,Intestines ,Endocrinology ,NG-Nitroarginine Methyl Ester ,chemistry ,symbols ,business ,Gastrointestinal Motility ,Colonic motility ,Reperfusion injury - Abstract
The present study aimed to examine whether and how colonic motility is affected by mild ischemia-induced intestinal injury in conscious rats through in vivo monitoring of colonic contractions, specifically with regard to the interstitial cells of Cajal (ICC) and the effect of nitric oxide (NO).Using miniature strain-gauge transducers, colonic motility with or without ischemia was recorded in conscious rats on the 4th, 7th, and 14th days after surgery. Histological examination for c-kit-positive cells was performed.In control nonischemic rats, the number and duration of contractions (NC and DC, respectively) decreased gradually, but the mean amplitude of contractions (MC) and motility index (MI) did not change. On the 7th day, the NC in the ischemic group increased significantly when compared with that in the control group (P = 0.037). The DC in the ischemic group was lower than that in the control group; the difference was significant on the 4th day (P = 0.008). The MIs in the ischemic group were lower than those in the control group. In both groups, administration of NGnitro-L: -arginine methyl ester on the 7th day increased only the resting cecal motility. Pathological examinations revealed c-kit-positive cells in both groups.Changes such as increased NC with shortened DC accompanied with decreased MI must have occurred at the ischemic site and might have been induced by an ischemic event. However, there exists a possibility that ICC and NO do not play a role in mild ischemia-induced dysmotility.
- Published
- 2007
20. P-070: Height at the time of diagnosis of inflammatory bowel disease in Japanese children: an analysis of Japanese national registry data
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E. Kuwabara, Yuji Nishiwaki, Hirokazu Arakawa, Takashi Ishige, Reiko Hatori, Takeshi Tomomasa, and Maiko Tatsuki
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Pediatrics ,medicine.medical_specialty ,business.industry ,Gastroenterology ,General Medicine ,Disease ,medicine.disease ,Sick child ,Inflammatory bowel disease ,Health centre ,hemic and lymphatic diseases ,medicine ,National registry ,business - Abstract
O-23 Effectiveness of nutritional and anti-TNF therapy in North American children with active Crohn’s disease D.Y. Lee1 *, R.N. Baldassano1, C.W. Compher2, A.M. Griffiths3, A.R. Otley4, L.G. Albenberg1, G.D. Wu2, F.D. Bushman2, J.D. Lewis2. 1Children’s Hospital of Philadelphia, Philadelphia, United States of America, 2University of Pennsylvania, Philadelphia, United States of America, 3The Hospital for Sick Children, Toronto, Canada, 4IWK Health Centre, Halifax, Canada
- Published
- 2014
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21. P-094: Efficacy of partial elemental nutrition as a maintenance therapy for pediatric Crohn’s disease
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Reiko Hatori, A. Tsuchiya, Maiko Tatsuki, Hirokazu Arakawa, N. Sakurai, Takashi Ishige, Takeshi Tomomasa, Yoshiko Igarashi, and K. Sekine
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medicine.medical_specialty ,Pediatric Crohn's disease ,Maintenance therapy ,business.industry ,Internal medicine ,Gastroenterology ,Medicine ,General Medicine ,business - Published
- 2014
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22. Temporal Trend of Pediatric Inflammatory Bowel Disease: Analysis of National Registry Data 2004 to 2013 in Japan.
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Takashi Ishige, Takeshi Tomomasa, Reiko Hatori, Maiko Tatsuki, Yoshiko Igarashi, Kazuhiko Sekine, Hirokazu Arakawa, Ishige, Takashi, Tomomasa, Takeshi, Hatori, Reiko, Tatsuki, Maiko, Igarashi, Yoshiko, Sekine, Kazuhiko, and Arakawa, Hirokazu
- Published
- 2017
- Full Text
- View/download PDF
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