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We are reporting a case of 75-year-old woman, who presented in E.R of Tabba Heart Institute, with complains of acute chest pain and shortness of breath. Initially patient was diagnosed and treated as acute coronary syndrome. Coronary angiography showed minimal atherosclerosis in epicardial arteries. Left ventriculogram showed apical ballooning with hyper contractile basal segments. Cardiac enzymes were elevated. Echocardiography revealed similar findings suggestive of Takotsubo cardiomyopathy (TCMP). She was managed medically and was discharged home in stable condition. At four months followup she was asymptomatic with normalization of ECG and ECHO findings. Takotsubo Cardiomyopathy should be considered in the differential diagnosis along with acute coronary syndrome in postmenopausal patients presenting with angina with orwithout stress or ECG changes and positive cardiac enzymes. [ABSTRACT FROM AUTHOR]