7 results on '"Reguzzi S"'
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2. Stratigraphic evolution of a spectacularly exposed turbidite channel belt from the Tachrift System (late Tortonian, north‐east Morocco)
- Author
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Reguzzi, S., primary, Marini, M., additional, Felletti, F., additional, Elkati, I., additional, Zuffetti, C., additional, and Tabyaoui, H., additional
- Published
- 2022
- Full Text
- View/download PDF
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3. A novel composition for in vitro and in vivo regeneration of skin and connective tissues
- Author
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Gennero, L, De Siena, R, Denysenko, Tetyana, Roos, Maria Augusta, Calisti, Gf, Martano, M, Fiobellot, S, Panzone, M, Reguzzi, S, Gabetti, L, Vercelli, A, Cavallo, Giovanni, Ricci, E, and Pescarmona, Gianpiero more...
- Subjects
Male ,Cell Survival ,Polydeoxyribonucleotides (PDRNs) ,l-carnitine ,calcium ions ,proteolytic enzymes ,antioxidant agents ,connective ,skin ,tissue regeneration ,Administration, Topical ,Biopsy ,Chemistry, Pharmaceutical ,Collagen Type I ,Mice ,Polydeoxyribonucleotides ,Diabetes Mellitus ,Animals ,Humans ,Collagen Type II ,Cells, Cultured ,Skin ,Wound Healing ,Staining and Labeling ,Body Weight ,Fibroblasts ,Immunohistochemistry ,Culture Media ,Connective Tissue ,Keratins - Abstract
The particular combination of polydeoxyribonucleotides, l-carnitine, calcium ions, proteolytic enzyme and other ingredients acts in a synergetic way in the regeneration of skin and connective tissues. This new formulation of active principles was tested in vitro as a cell and tissue culture medium and in vivo for various preparations in support of tissue regeneration. In vitro, the new blend allowed the maintenance of skin biopsies for more than 1 year in eutrophic conditions. Immunocytochemical analyses of fibroblasts isolated from these biopsies confirmed a significant increase of the epidermal and connective wound-healing markers such as collagen type I, collagen type IV, cytokeratin 1 (CK1), CK5, CK10 and CK14 versus controls. To examine the effects of the new compound in vivo, we studied impaired wound healing in genetically diabetic db/db mice. At day 18, diabetic mice treated with the new composition showed 100% closure of wounds and faster healing than mice treated with the other solutions. This complex of vital continuity factors or life-keeping factors could be used as a tissue-preserving solution or a cosmetic/drug/medical device to accelerate wound healing in the treatment of patients with deficient wound repair to promote the regeneration of cutaneous and connective tissues (injuries-wound, dermatitis) and prevent the recurrent relapses. more...
- Published
- 2011
4. Petrographic data from the Oligocene-lower Langhian succession of the Arquata Scrivia area in the Tertiary Piedmont Basin (NW Italy).
- Author
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Invernizzi D, Reguzzi S, and Felletti F
- Abstract
This petrographic database is a compilation made to study the Oligocene-Langhian succession of the Arquata Scrivia area, consisting of different shallow to deep-water marine sedimentary units deposited in the eastern Tertiary Piedmont Basin (NW Italy). This database is unique for the studied succession, which was not priorly investigated for the petrographic content of its component units. The samples were collected from lower, middle and upper parts of each sedimentary unit and analyzed for identifying their petrographic composition via qualitative and quantitative methods by means of polarized-light microscope. The collected petrographic data are presented within quartz-feldspar-lithic ternary plots. Even though these data are elementary analytical outputs, they represent the starting point for future analyses in order to understand the evolution of the basin on a larger scale., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships which have or could be perceived to have influenced the work reported in this article., (© 2022 The Authors.) more...
- Published
- 2022
- Full Text
- View/download PDF
5. Microparticles in physiological and in pathological conditions.
- Author
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Roos MA, Gennero L, Denysenko T, Reguzzi S, Cavallo G, Pescarmona GP, and Ponzetto A
- Subjects
- Animals, Biological Therapy trends, Biomarkers blood, Cell-Derived Microparticles chemistry, Drug Delivery Systems trends, Eukaryotic Cells physiology, Humans, Biological Therapy methods, Cell-Derived Microparticles physiology, Chronic Disease therapy
- Abstract
Chronic diseases pose a severe burden to modern National Health Systems. Individuals nowadays have a far more extended lifespan than in the past, but healthy living was only scantily extended. As much as longer life is desirable, it is saddened by chronic diseases and organ malfunctions. One contributor to these problems was recognized to be represented by microparticles (MPs). Our purpose is to better understand MPs, to contrast their ominous threat and possible clinical importance. For this intent we correlated MPs with thrombotic pathologies, hemophilia, malaria, diabetes, cardiovascular diseases, endothelial dysfunctions, pulmonary hypertension, ischemic stroke, pre-eclampsia, rheumatologic diseases-rheumatoid arthritis, polymyositis-dermatomyositis, angiogenesis and tumor progression-cancer; we listed the possibilities of using them to improve transfusion methods, as a marker for acute allograft rejection, in stem cell transplantation, as neuronal biomarkers, to understand gender-specific susceptibility for diseases and to improve vaccination methods and we presented some methods for the detection of MPs., (Copyright © 2010 John Wiley & Sons, Ltd.) more...
- Published
- 2010
- Full Text
- View/download PDF
6. Glioblastoma cancer stem cells: heterogeneity, microenvironment and related therapeutic strategies.
- Author
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Denysenko T, Gennero L, Roos MA, Melcarne A, Juenemann C, Faccani G, Morra I, Cavallo G, Reguzzi S, Pescarmona G, and Ponzetto A
- Subjects
- AC133 Antigen, Antigens, CD metabolism, Combined Modality Therapy, Drug Resistance, Neoplasm, Glioblastoma immunology, Glycoproteins metabolism, Humans, Neoplastic Stem Cells cytology, Peptides metabolism, Glioblastoma therapy, Neoplastic Stem Cells metabolism
- Abstract
Glioblastoma Multiforme (GBM) is an incurable malignancy. GBM patients have a short life expectancy despite aggressive therapeutic approaches based on surgical resection followed by adjuvant radiotherapy and concomitant chemotherapy. Glioblastoma growth is characterized by a high motility of tumour cells, their resistance to both chemo/radio-therapy, apoptosis inhibition leading to failure of conventional therapy. Cancer Stem Cells (CSCs), identified in GBM as well as in many other cancer types, express the membrane antigen prominin-1 (namely CD133). These cells and normal Neural Stem Cells (NSC) share surface markers and properties, i.e. are able to self-renew and differentiate into multiple cell types. Stem cell self-renewal depends on microenvironmental cues, including Extracellular Matrix (ECM) composition and cell types. Therefore, the role of microenvironment needs to be evaluated to clarify its importance in tumour initiation and progression through CSCs. The specific microenvironment of CSCs was found to mimic in part the vascular niche of normal stem cells. The targeting of GMB CSCs may represent a powerful treatment approach. Lastly, in GBM patients cancer-initiating cells contribute to the profound immune suppression that in turn correlated with CSCs STAT3 (CD133 + ). Further studies of microenvironment are needed to better understand the origin of GMB/GBM CSCs and its immunosuppressive properties., (Copyright 2010 John Wiley & Sons, Ltd.) more...
- Published
- 2010
- Full Text
- View/download PDF
7. Pluripotent plasticity of stem cells and liver repopulation.
- Author
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Gennero L, Roos MA, Sperber K, Denysenko T, Bernabei P, Calisti GF, Papotti M, Cappia S, Pagni R, Aimo G, Mengozzi G, Cavallo G, Reguzzi S, Pescarmona GP, and Ponzetto A
- Subjects
- Animals, Cell Lineage, Humans, Intercellular Signaling Peptides and Proteins metabolism, Liver Diseases pathology, Liver Diseases therapy, Oxidative Stress, Pluripotent Stem Cells cytology, Stem Cell Transplantation, Cell Differentiation physiology, Liver cytology, Liver pathology, Liver physiology, Liver Regeneration physiology, Pluripotent Stem Cells physiology
- Abstract
Different types of stem cells have a role in liver regeneration or fibrous repair during and after several liver diseases. Otherwise, the origin of hepatic and/or extra-hepatic stem cells in reactive liver repopulation is under controversy. The ability of the human body to self-repair and replace the cells and tissues of some organs is often evident. It has been estimated that complete renewal of liver tissue takes place in about a year. Replacement of lost liver tissues is accomplished by proliferation of mature hepatocytes, hepatic oval stem cells differentiation, and sinusoidal cells as support. Hepatic oval cells display a distinct phenotype and have been shown to be a bipotential progenitor of two types of epithelial cells found in the liver, hepatocytes, and bile ductular cells. In gastroenterology and hepatology, the first attempts to translate stem cell basic research into novel therapeutic strategies have been made for the treatment of several disorders, such as inflammatory bowel diseases, diabetes mellitus, celiachy, and acute or chronic hepatopaties. In the future, pluripotent plasticity of stem cells will open a variety of clinical application strategies for the treatment of tissue injuries, degenerated organs. The promise of liver stem cells lie in their potential to provide a continuous and readily available source of liver cells that can be used for gene therapy, cell transplant, bio-artificial liver-assisted devices, drug toxicology testing, and use as an in vitro model to understand the developmental biology of the liver., (Copyright (c) 2010 John Wiley & Sons, Ltd.) more...
- Published
- 2010
- Full Text
- View/download PDF
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