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2. First records of Utricularia breviscapa C. Wright ex Griseb. (Lentibulariaceae) for Maranhão state, northeastern Brazil

Author

Mateus C.A. Pestana, Niksoney A. Mendonça, Rafael F. Oliveira, Maria da C. C. Bastos, Maria I. Silva, Amabille M. Barroso, Regis C. Hora, and Elidio A. E. Guarçoni

Subjects
Aquatic macrophytes, carnivorous plant, Cerrado, Biology (General), QH301-705.5
Abstract

We report the first record of Utricularia breviscapa from the state of Maranhão, northeastern Brazil. We collected this species in the municipality of Chapadinha, eastern Maranhão, within the Cerrado domain. This work adds new information on the flora of Maranhão and on the distribution of U. breviscapa. Illustrations and descriptions are also provided.

Published
2022
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8. Search for n-n ¯ oscillation in Super-Kamiokande SEARCH FOR n-n ¯ OSCILLATION IN SUPER-⋯ K. ABE et al.

Author

Abe, K, Hayato, Y, Iida, T, Ishihara, K, Kameda, J, Koshio, Y, Minamino, A, Mitsuda, C, Miura, M, Moriyama, S, Nakahata, M, Obayashi, Y, Ogawa, H, Sekiya, H, Shiozawa, M, Suzuki, Y, Takeda, A, Takeuchi, Y, Ueshima, K, Watanabe, H, Higuchi, I, Ishihara, C, Ishitsuka, M, Kajita, T, Kaneyuki, K, Mitsuka, G, Nakayama, S, Nishino, H, Okumura, K, Saji, C, Takenaga, Y, Clark, S, Desai, S, Dufour, F, Herfurth, A, Kearns, E, Likhoded, S, Litos, M, Raaf, JL, Stone, JL, Sulak, LR, Wang, W, Goldhaber, M, Casper, D, Cravens, JP, Dunmore, J, Griskevich, J, Kropp, WR, Liu, DW, Mine, S, Regis, C, Smy, MB, Sobel, HW, Vagins, MR, Ganezer, KS, Hartfiel, B, Hill, J, Keig, WE, Jang, JS, Jeoung, IS, Kim, JY, Lim, IT, Scholberg, K, Tanimoto, N, Walter, CW, Wendell, R, Ellsworth, RW, Tasaka, S, Guillian, G, Learned, JG, Matsuno, S, Messier, MD, Ichikawa, AK, Ishida, T, Ishii, T, Iwashita, T, Kobayashi, T, Nakadaira, T, Nakamura, K, Nishikawa, K, Nitta, K, Oyama, Y, Suzuki, AT, Hasegawa, M, Maesaka, H, Nakaya, T, Sasaki, T, Sato, H, Tanaka, H, Yamamoto, S, Yokoyama, M, Haines, TJ, Dazeley, S, Hatakeyama, S, Svoboda, R, Sullivan, GW, Gran, R, Habig, A, Fukuda, Y, and Itow, Y

Subjects
hep-ex, Nuclear & Particles Physics, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Quantum Physics, Atomic, Molecular, Nuclear, Particle and Plasma Physics
Abstract

A search for neutron-antineutron (n-n¯) oscillation was undertaken in Super-Kamiokande using the 1489 live-day or 2.45×1034 neutron-year exposure data. This process violates both baryon and baryon minus lepton numbers by an absolute value of two units and is predicted by a large class of hypothetical models where the seesaw mechanism is incorporated to explain the observed tiny neutrino masses and the matter-antimatter asymmetry in the Universe. No evidence for n-n¯ oscillation was found; the lower limit of the lifetime for neutrons bound in O16, in an analysis that included all of the significant sources of experimental uncertainties, was determined to be 1.9×1032years at the 90% confidence level. The corresponding lower limit for the oscillation time of free neutrons was calculated to be 2.7×108s using a theoretical value of the nuclear suppression factor of 0.517×1023s-1 and its uncertainty.

Published
2015

9. Search for n−n¯ oscillation in Super-Kamiokande

Author

Abe, K, Hayato, Y, Iida, T, Ishihara, K, Kameda, J, Koshio, Y, Minamino, A, Mitsuda, C, Miura, M, Moriyama, S, Nakahata, M, Obayashi, Y, Ogawa, H, Sekiya, H, Shiozawa, M, Suzuki, Y, Takeda, A, Takeuchi, Y, Ueshima, K, Watanabe, H, Higuchi, I, Ishihara, C, Ishitsuka, M, Kajita, T, Kaneyuki, K, Mitsuka, G, Nakayama, S, Nishino, H, Okumura, K, Saji, C, Takenaga, Y, Clark, S, Desai, S, Dufour, F, Herfurth, A, Kearns, E, Likhoded, S, Litos, M, Raaf, JL, Stone, JL, Sulak, LR, Wang, W, Goldhaber, M, Casper, D, Cravens, JP, Dunmore, J, Griskevich, J, Kropp, WR, Liu, DW, Mine, S, Regis, C, Smy, MB, Sobel, HW, Vagins, MR, Ganezer, KS, Hartfiel, B, Hill, J, Keig, WE, Jang, JS, Jeoung, IS, Kim, JY, Lim, IT, Scholberg, K, Tanimoto, N, Walter, CW, Wendell, R, Ellsworth, RW, Tasaka, S, Guillian, G, Learned, JG, Matsuno, S, Messier, MD, Ichikawa, AK, Ishida, T, Ishii, T, Iwashita, T, Kobayashi, T, Nakadaira, T, Nakamura, K, Nishikawa, K, Nitta, K, Oyama, Y, Suzuki, AT, Hasegawa, M, Maesaka, H, Nakaya, T, Sasaki, T, Sato, H, Tanaka, H, Yamamoto, S, Yokoyama, M, Haines, TJ, Dazeley, S, Hatakeyama, S, Svoboda, R, Sullivan, GW, Gran, R, Habig, A, Fukuda, Y, and Itow, Y

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, hep-ex, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Quantum Physics, Nuclear & Particles Physics, Mathematical physics, Astronomical sciences, Particle and high energy physics
Abstract

A search for neutron-antineutron (n-n¯) oscillation was undertaken in Super-Kamiokande using the 1489 live-day or 2.45×1034 neutron-year exposure data. This process violates both baryon and baryon minus lepton numbers by an absolute value of two units and is predicted by a large class of hypothetical models where the seesaw mechanism is incorporated to explain the observed tiny neutrino masses and the matter-antimatter asymmetry in the Universe. No evidence for n-n¯ oscillation was found; the lower limit of the lifetime for neutrons bound in O16, in an analysis that included all of the significant sources of experimental uncertainties, was determined to be 1.9×1032years at the 90% confidence level. The corresponding lower limit for the oscillation time of free neutrons was calculated to be 2.7×108s using a theoretical value of the nuclear suppression factor of 0.517×1023s-1 and its uncertainty.

Published
2015

10. Strategies to Enhance the Likelihood that Teachers Will Integrate Technology into Their Classrooms

Author

Patter, Regis C.

Abstract

This study examined the factors that enhance the likelihood that teachers will integrate technology into their classrooms. Starting with a historical perspective on technology integration, the study categorized these factors and shed light on which ones have become obstacles. If obstacles or barriers are identified, then eliminated or at least minimized, the likelihood of teachers' integrating technology into their classrooms may become a more promising realization. Another integral part of this study discussed strategies utilized in models of teacher professional development with the intent of identifying which approaches or models, or combinations thereof, had the best chance for successful implementation. The literature suggested that traditional or standard professional development approaches have not proved very successful. School-based and self-directed models, having evolved somewhat over the years, have shown more promise, although no singular approach can be recommended to suit schools overall. Instead, a combination of these approaches, as well as the addition of a student-based approach was recommended. The goal of this study was to provide data that may be used to create new alternatives for training educators. This study adds to the limited research regarding effective teacher professional development in the area of technology integration. Schools will be able to use the data to re-think, re-organize and add valuable training resources to their current staff development design. This reorganization is needed so that educators are properly prepared to educate millennium students in a new-age classroom.

Published
2009

11. A Search for Nucleon Decay via $n \rightarrow \bar{\nu} \pi^{0}$ and $p \rightarrow \bar{\nu} \pi^{+}$ in Super-Kamiokande

Author

Collaboration, Super-Kamiokande, Abe, K., Hayato, Y., Iida, T., Iyogi, K., Kameda, J., Koshio, Y., Kozuma, Y., Marti, Ll., Miura, M., Moriyama, S., Nakahata, M., Nakayama, S., Obayashi, Y., Sekiya, H., Shiozawa, M., Suzuki, Y., Takeda, A., Takenaga, Y., Ueno, K., Ueshima, K., Yamada, S., Yokozawa, T., Ishihara, C., Kaji, H., Kajita, T., Kaneyuki, K., Lee, K. P., McLachlan, T., Okumura, K., Shimizu, Y., Tanimoto, N., Kearns, E., Litos, M., Raaf, J. L., Stone, J. L., Sulak, L. R., Goldhaber, M., Bays, K., Kropp, W. R., Mine, S., Regis, C., Renshaw, A., Smy, M. B., Sobel, H. W., Ganezer, K. S., Hill, J., Keig, W. E., Jang, J. S., Kim, J. Y., Lim, I. T., Albert, J. B., Scholberg, K., Walter, C. W., Wendell, R., Wongjirad, T. M., Ishizuka, T., Tasaka, S., Learned, J. G., Matsuno, S., Smith, S. N., Hasegawa, T., Ishida, T., Ishii, T., Kobayashi, T., Nakadaira, T., Nakamura, K., Nishikawa, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Suzuki, A. T., Takeuchi, Y., Ikeda, M., Minamino, A., Nakaya, T., Fukuda, Y., Itow, Y., Mitsuka, G., Tanaka, T., Jung, C. K., Lopez, G. D., Taylor, I., Yanagisawa, C., Ishino, H., Kibayashi, A., Mino, S., Mori, T., Sakuda, M., Toyota, H., Kuno, Y., Yoshida, M., Kim, S. B., Yang, B. S., Okazawa, H., Choi, Y., Nishijima, K., Koshiba, M., Yokoyama, M., Totsuka, Y., Martens, K., Schuemann, J., Vagins, M. R., Chen, S., Heng, Y., Yang, Z., Zhang, H., Kielczewska, D., Mijakowski, P., Connolly, K., Dziomba, M., Thrane, E., and Wilkes, R. J.

Subjects
High Energy Physics - Experiment
Abstract

We present the results of searches for nucleon decay via bound neutron to antineutrino plus pizero and proton to antineutrino plus piplus using data from a combined 172.8 kiloton-years exposure of Super-Kamiokande-I, -II, and -III. We set lower limits on the partial lifetime for each of these modes. For antineutrino pizero, the partial lifetime is >1.1x10^{33} years; for antineutrino piplus, the partial lifetime is >3.9x10^{32} years at 90% confidence level., Comment: 6 pages, 5 figures, submitted to Physical Review Letters

Published
2013
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13. Design and synthesis of nanoparticles functionalised with Lewis oligosaccharides for selective targeting of DC-SIGN

Author

Saliba, Regis C. and Davis, Benjamin G.

Subjects
547, Organic chemistry, Chemical biology, Organic synthesis, Natural products, Synthetic organic chemistry
Abstract

Dendritic cells (DC) are one of the major antigen presenting cells (APC) of the body. They, by capture of antigen and cross-presentation of these antigens, activate dormant T-cells and co-activate B-cells. As such they regulate the immune system toward either a more humoral type immune response or a more cellular type immune response. These properties have made them very studied over the past decade and many works have focus on the development of vaccine or therapeutic using DCs as a target. However, most of these actual studies have been done by injection of in vitro pre-activated DCs. The major drawback of this technique is the use of non-natural and non individual specific DCs (monocytes derived DCs and/or stem cells DCs). That is why therapeutic carrier targeting specifically DCs has to be developed. To achieve this goal, specific molecules present at the surface of DCs and involved in the activation of the immune system has to be targeted. Among them, DC-Specific ICAM-3 Grabbing Non-integrin CD209 (DC-SIGN) is very specifically expressed only on one subset of DCs called interstitial DCs. This lectin has been proven to be one of the first contacts of the DCs with T-cells and to induce one major interaction for cells proliferation of dormant T-cells. The goal of the project is to design a probe that can be used in vivo and post-mortem to target DCs via DC-SIGN. Therefore, we can use these particles as a proof of concept in vivo and in vitro, record the immune response obtained with them in vivo and in vitro and design probes that can be used to induce specific immune response for future therapy development. Lewis sugars have been shown to be quite specific to DC-SIGN. Their syntheses have been carried out in our lab with a cyanomethylthio linker at their anomeric position. This linker, once activated as a 2-imino-2-methoxyethyl moiety, has permitted the attachment of the oligosaccharides at the surface of dextran-coated iron oxide MRI nanoparticle. These particles have been chosen for their powerful properties and the advantage of the technique they are used for. Indeed, as particles their sizes mimic pathogens and DCs would interact with them, as they will with pathogen. Moreover, many copies of each oligosaccharide could be attached at their surface enhancing the interaction of the particles with the targeted lectin via a multivalent effect. As a technique, MRI has the advantage to be recorded over a long period of time (compare to 18F PET for example), with a relatively low signal/noise ratio (compare to fluorescence techniques) and without being harmful. FITC fluorescent Lewis X nanoparticles have been actually design and characterised (size by DLS, number of sugar by particles by ICP or fluorescamine fluorescence assay and binding affinity by ELISA with DC-SIGN-Fc). They have been first tested in vitro with models cells (Raji and monocytes derived DCs) for specific uptake assays, where they exhibit specific uptake and internalisation. Lewis-x nanoparticles have also been tested in vivo in a rat model and have been shown to be retained in Lymph nodes compared to control particles. Post mortem analysis appears to demonstrate that these particles were internalised by rat DCs and transported in the centre of the lymph node known as the T-cell region. Finally, cytokines and CD86 concentration measurement have shown that upon internalisation of the nanoparticles, DC maturated. In addition, an antigenic OVA peptide epitope was attached to the surface of the nanoparticles for future T-cell proliferation experiments. It will allow the determination of the immune response expected. In summary, we have developed an immunogenic MRI-active probe that can target specifically DC-SIGN via the interaction with Lewis antigens present at the surface of the probe and trigger DC maturation.

Published
2014

14. Search for Proton Decay into Muon plus Neutral Kaon in Super-Kamiokande I, II, and III

Author

Collaboration, The Super-Kamiokande, Regis, C., Abe, K., Hayato, Y., Iyogi, K., Kameda, J., Koshio, Y., Marti, Ll., Miura, M., Moriyama, S., Nakahata, M., Nakayama, S., Obayashi, Y., Sekiya, H., Shiozawa, M., Suzuki, Y., Takeda, A., Takenaga, Y., Ueno, K., Yokozawa, T., Kaji, H., Kajita, T., Kaneyuki, K., Lee, K. P., Okumura, K., McLachlan, T., Labarga, L., Kearns, E., Raaf, J. L., Stone, J. L., Sulak, L. R., Goldhaber, M., Bays, K., Carminati, G., Kropp, W. R., Mine, S., Renshaw, A., Smy, M. B., Sobel, H. W., Ganezer, K. S., Hill, J., Keig, W. E., Jang, J. S., Kim, J. Y., Lim, I. T., Albert, J. B., Scholberg, K., Walter, C. W., Wendell, R. A., Wongjirad, T., Ishizuka, T., Tasaka, S., Learned, J. G., Matsuno, S., Smith, S. N., Hasegawa, T., Ishida, T., Ishii, T., Kobayashi, T., Nakadaira, T., Nakamura, K., Nishikawa, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Suzuki, A. T., Takeuchi, Y., Ieki, K., Ikeda, M., Kubo, H., Minamino, A., Murakami, A., Nakaya, T., Fukuda, Y., Choi, K., Itow, Y., Mitsuka, G., Miyake, M., Mijakowski, P., Hignight, J., Imber, J., Jung, C. K., Taylor, I., Yanagisawa, C., Ishino, H., Kibayashi, A., Mori, T., Sakuda, M., Takeuchi, J., Kuno, Y., Kim, S. B., Okazawa, H., Choi, Y., Nishijima, K., Koshiba, M., Totsuka, Y., Yokoyama, M., Martens, K., Vagins, M. R., Chen, S., Sui, H., Yang, Z., Zhang, H., Connolly, K., Dziomba, M., and Wilkes, R. J.

Subjects
High Energy Physics - Experiment
Abstract

We have searched for proton into muon plus neutral kaon using data from a 91.7 kiloton-year exposure of Super-Kamiokande-I, a 49.2 kiloton-year exposure of Super-Kamiokande-II, and a 31.9 kiloton-year exposure of Super-Kamiokande-III. The number of candidate events in the data was consistent with the atmospheric neutrino background expectation and no evidence for proton decay in this mode was found. We set a partial lifetime lower limit of 1.6x10^33 years at the 90% confidence level., Comment: 15 pages, 13 figures

Published
2012
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15. Search for Nucleon Decay into Charged Anti-lepton plus Meson in Super-Kamiokande I and II

Author

Collaboration, Super-Kamiokande, Nishino, H., Abe, K., Hayato, Y., Iida, T., Ikeda, M., Kameda, J., Koshio, Y., Miura, M., Moriyama, S., Nakahata, M., Nakayama, S., Obayashi, Y., Sekiya, H., Shiozawa, M., Suzuki, Y., Takeda, A., Takenaga, Y., Takeuchi, Y., Ueno, K., Ueshima, K., Watanabe, H., Yamada, S., Hazama, S., Higuchi, I., Ishihara, C., Kaji, H., Kajita, T., Kaneyuki, K., Mitsuka, G., Okumura, K., Tanimoto, N., Dufour, F., Kearns, E., Litos, M., Raaf, J. L., Stone, J. L., Sulak, L. R., Goldhaber, M., Bays, K., Cravens, J. P., Kropp, W. R., Mine, S., Regis, C., Smy, M. B., Sobel, H. W., Ganezer, K. S., Hill, J., Keig, W. E., Jang, J. S., Kim, J. Y., Lim, I. T., Albert, J. B., Scholberg, K., Walter, C. W., Wendell, R., Ishizuka, T., Tasaka, S., Learned, J. G., Matsuno, S., Watanabe, Y., Hasegawa, T., Ishida, T., Ishii, T., Kobayashi, T., Nakadaira, T., Nakamura, K., Nishikawa, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Suzuki, A. T., Minamino, A., Nakaya, T., Yokoyama, M., Fukuda, Y., Itow, Y., Tanaka, T., Jung, C. K., Lopez, G., McGrew, C., Yanagisawa, C., Tamura, N., Idehara, Y., Sakuda, M., Kuno, Y., Yoshida, M., Kim, S. B., Yang, B. S., Okazawa, H., Choi, Y., Seo, H. K., Furuse, Y., Nishijima, K., Yokosawa, Y., Koshiba, M., Totsuka, Y., Vagins, M. R., Chen, S., Heng, Y., Liu, J., Yang, Z., Zhang, H., Kielczewska, D., Connolly, K., Thrane, E., and Wilkes, R. J.

Subjects
High Energy Physics - Experiment
Abstract

Searches for a nucleon decay into a charged anti-lepton (e^+ or {\mu}^+) plus a light meson ({\pi}^0, {\pi}^-, {\eta}, {\rho}^0, {\rho}^-, {\omega}) were performed using the Super-Kamiokande I and II data. Twelve nucleon decay modes were searched for. The total exposure is 140.9 kiloton \cdot years, which includes a 91.7 kiloton \cdot year exposure (1489.2 live days) of Super-Kamiokande-I and a 49.2 kiloton \cdot year exposure (798.6 live days) of Super-Kamiokande-II. The number of candidate events in the data was consistent with the atmospheric neutrino background expectation. No significant evidence for a nucleon decay was observed in the data. Thus, lower limits on the nucleon partial lifetime at 90% confidence level were obtained. The limits range from 3.6 \times 10^31 to 8.2 \times 10^33 years, depending on the decay modes., Comment: 25 pages, 18 figures

Published
2012
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16. Search for GUT Monopoles at Super-Kamiokande

Author

Collaboration, The Super-Kamiokande, Ueno, K., Abe, K., Hayato, Y., Iida, T., Iyogi, K., Kameda, J., Koshio, Y., Kozuma, Y., Miura, M., Moriyama, S., Nakahata, M., Nakayama, S., Obayashi, Y., Sekiya, H., Shiozawa, M., Suzuki, Y., Takeda, A., Takenaga, Y., Ueshima, K., Yamada, S., Yokozawa, T., Martens, K., Schuemann, J., Vagins, M., Ishihara, C., Kaji, H., Kajita, T., Kaneyuki, K., McLachlan, T., Okumura, K., Shimizu, Y., Tanimoto, N., Kearns, E., Litos, M., Raaf, J. L., Stone, J. L., Sulak, L. R., Bays, K., Kropp, W. R., Mine, S., Regis, C., Renshaw, A., Smy, M. B., Sobel, H. W., Ganezer, K. S., Hill, J., Keig, W. E., Jang, J. S., Kim, J. Y., Lim, I. T., Albert, J. B., Scholberg, K., Walter, C. W., Wendell, R., Wongjirad, T., Ishizuka, T., Tasaka, S., Learned, J. G., Matsuno, S., Hasegawa, T., Ishida, T., Ishii, T., Kobayashi, T., Nakadaira, T., Nakamura, K., Nishikawa, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Suzuki, A. T., Takeuchi, Y., Ikeda, M., Minamino, A., Nakaya, T., Labarga, L., Marti, Ll., Fukuda, Y., Itow, Y., Mitsuka, G., Tanaka, T., Jung, C. K., Lopez, G., Taylor, I., Yanagisawa, C., Ishino, H., Kibayashi, A., Mino, S., Mori, T., Sakuda, M., Toyota, H., Kuno, Y., Yoshida, M., Kim, S. B., Yang, B. S., Okazawa, H., Choi, Y., Nishijima, K., Koshiba, M., Totsuka, Y., Yokoyama, M., Chen, S., Heng, Y., Yang, Z., Zhang, H., Kielczewska, D., Mijakowski, P., Connolly, K., Dziomba, M., Thrane, E., and Wilkes, R. J.

Subjects
High Energy Physics - Experiment, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Solar and Stellar Astrophysics
Abstract

GUT monopoles captured by the Sun's gravitation are expected to catalyze proton decays via the Callan-Rubakov process. In this scenario, protons, which initially decay into pions, will ultimately produce \nu_{e}, \nu_{\mu} and \bar{\nu}_{\mu}. After undergoing neutrino oscillation, all neutrino species appear when they arrive at the Earth, and can be detected by a 50,000 metric ton water Cherenkov detector, Super-Kamiokande (SK). A search for low energy neutrinos in the electron total energy range from 19 to 55 MeV was carried out with SK and gives a monopole flux limit of F_M(\sigma_0/1 mb) < 6.3 \times 10^{-24} (\beta_M/10^{-3})^2 cm^{-2} s^{-1} sr^{-1} at 90% C.L., where \beta_M is the monopole velocity in units of the speed of light and \sigma_0 is the catalysis cross section at \beta_M=1. The obtained limit is more than eight orders of magnitude more stringent than the current best cosmic-ray supermassive monopole flux limit, F_M < 1 \times 10^{-15} cm^{-2} s^{-1} sr^{-1} for \beta_M < 10^{-3} and also two orders of magnitude lower than the result of the Kamiokande experiment, which used a similar detection method., Comment: 15 pages, 6 figures

Published
2012
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17. Effect of Prior Exercise on Postprandial Lipemia: An Updated Meta-Analysis and Systematic Review.

Author

Pearson, Regis C., Cogan, Betsy, Garcia, Sara A., and Jenkins, Nathan T.

Subjects
*TRIGLYCERIDES, *ENERGY metabolism, *META-analysis, *FOOD consumption, *SYSTEMATIC reviews, *EFFECT sizes (Statistics), *HYPERLIPIDEMIA, *EXERCISE, *DESCRIPTIVE statistics
Abstract

The purpose of this systematic review was to synthesize the results from current literature examining the effects of prior exercise on the postprandial triglyceride (TG) response to evaluate current literature and provide future direction. A quantitative review was performed using meta-analytic methods to quantify individual effect sizes. A moderator analysis was performed to investigate potential variables that could influence the effect of prior exercise on postprandial TG response. Two hundred and seventy-nine effects were retrieved from 165 studies for the total TG response and 142 effects from 87 studies for the incremental area under the curve TG response. There was a moderate effect of exercise on the total TG response (Cohen's d = −0.47; p <.0001). Moderator analysis revealed exercise energy expenditure significantly moderated the effect of prior exercise on the total TG response (p <.0001). Exercise modality (e.g., cardiovascular, resistance, combination of both cardiovascular and resistance, or standing), cardiovascular exercise type (e.g., continuous, interval, concurrent, or combined), and timing of exercise prior to meal administration significantly affected the total TG response (p <.001). Additionally, exercise had a moderate effect on the incremental area under the curve TG response (Cohen's d = −0.40; p <.0001). The current analysis reveals a more homogeneous data set than previously reported. The attenuation of postprandial TG appears largely dependent on exercise energy expenditure (∼2 MJ) and the timing of exercise. The effect of prior exercise on the postprandial TG response appears to be transient; therefore, exercise should be frequent to elicit an adaptation. [ABSTRACT FROM AUTHOR]

Published
2022
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19. Supernova Relic Neutrino Search at Super-Kamiokande

Author

Collaboration, The Super-Kamiokande, Bays, K., Iida, T., Abe, K., Hayato, Y., Iyogi, K., Kameda, J., Koshio, Y., Marti, L., Miura, M., Moriyama, S., Nakahata, M., Nakayama, S., Obayashi, Y., Sekiya, H., Shiozawa, M., Suzuki, Y., Takeda, A., Takenaga, Y., Ueno, K., Kajita, K. Ueshima S. Yamada T. Yokozawa H. Kaji T., Kaneyuki, K., McLachlan, T., Okumura, K., Pik, L. K., Martens, K., Vagins, M., Labarga, L., Kearns, E., Litos, M., Raaf, J. L., Stone, J. L., Sulak, L. R., Kropp, W. R., Mine, S., Regis, C., Renshaw, A., Smy, M. B., Sobel, H. W., Ganezer, K. S., Hill, J., Keig, W. E., Cho, S., Jang, J. S., Kim, J. Y., Lim, I. T., Albert, J., Scholberg, K., Walter, C. W., Wendell, R., Wongjirad, T., Ishizuka, T., Tasaka, S., Learned, J. G., Matsuno, S., Smith, S., Hasegawa, T., Ishida, T., Ishii, T., Kobayashi, T., Nakadaira, T., Nakamura, K., Nishikawa, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Suzuki, A. T., Takeuchi, Y., Ikeda, M., Matsuoka, K., Minamino, A., Murakami, A., Nakaya, T., Fukuda, Y., Itow, Y., Mitsuka, G., Miyake, M., Tanaka, T., Hignight, J., Imber, J., Jung, C. K., Taylor, I., Yanagisawa, C., Kibayashi, A., Ishino, H., Mino, S., Sakuda, M., Mori, T., Toyota, H., Kuno, Y., Kim, S. B., Yang, B. S., Okazawa, H., Choi, Y., Nishijima, K., Koshiba, M., Totsuka, Y., Yokoyama, M., Heng, Y., Chen, S., Zhang, H., Yang, Z., Mijakowski, P., Connolly, K., Dziomba, M., and Wilkes, R. J.

Subjects
High Energy Physics - Experiment
Abstract

A new Super-Kamiokande (SK) search for Supernova Relic Neutrinos (SRNs) was conducted using 2853 live days of data. Sensitivity is now greatly improved compared to the 2003 SK result, which placed a flux limit near many theoretical predictions. This more detailed analysis includes a variety of improvements such as increased efficiency, a lower energy threshold, and an expanded data set. New combined upper limits on SRN flux are between 2.8 and 3.0 nu_e cm^-2 s^-1 > 16 MeV total positron energy (17.3 MeV E_nu).

Published
2011
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20. Search for n-nbar oscillation in Super-Kamiokande

Author

collaboration, Super-Kamiokande, Abe, K., Hayato, Y., Iida, T., Ishihara, K., Kameda, J., Koshio, Y., Minamino, A., Mitsuda, C., Miura, M., Moriyama, S., Nakahata, M., Obayashi, Y., Ogawa, H., Sekiya, H., Shiozawa, M., Suzuki, Y., Takeda, A., Takeuchi, Y., Ueshima, K., Watanabe, H., Higuchi, I., Ishihara, C., Ishitsuka, M., Kajita, T., Kaneyuki, K., Mitsuka, G., Nakayama, S., Nishino, H., Okumura, K., Saji, C., Takenaga, Y., Clark, S., Desai, S., Dufour, F., Herfurth, A., Kearns, E., Likhoded, S., Litos, M., Raaf, J. L., Stone, J. L., Sulak, L. R., Wang, W., Goldhaber, M., Casper, D., Cravens, J. P., Dunmore, J., Griskevich, J., Kropp, W. R., Liu, D. W., Mine, S., Regis, C., Smy, M. B., Sobel, H. W., Vagins, M. R., Ganezer, K. S., Hartfiel, B., Hill, J., Keig, W. E., Jang, J. S., Jeoung, I. S., Kim, J. Y., Lim, I. T., Scholberg, K., Tanimoto, N., Walter, C. W., Wendell, R., Ellsworth, R. W., Tasaka, S., Guillian, G., Learned, J. G., Matsuno, S., Messier, M. D., Ichikawa, A. K., Ishida, T., Ishii, T., Iwashita, T., Kobayashi, T., Nakadaira, T., Nakamura, K., Nishikawa, K., Nitta, K., Oyama, Y., Suzuki, A. T., Hasegawa, M., Maesaka, H., Nakaya, T., Sasaki, T., Sato, H., Tanaka, H., Yamamoto, S., Yokoyama, M., Haines, T. J., Dazeley, S., Hatakeyama, S., Svoboda, R., Sullivan, G. W., Gran, R., Habig, A., Fukuda, Y., Itow, Y., Koike, T., Jung, C. K., Kato, T., Kobayashi, K., McGrew, C., Sarrat, A., Terri, R., Yanagisawa, C., Tamura, N., Ikeda, M., Sakuda, M., Kuno, Y., Yoshida, M., Kim, S. B., Yang, B. S., Ishizuka, T., Okazawa, H., Choi, Y., Seo, H. K., Gando, Y., Hasegawa, T., Inoue, K., Ishii, H., Nishijima, K., Ishino, H., Watanabe, Y., Koshiba, M., Totsuka, Y., Chen, S., Deng, Z., Liu, Y., Kielczewska, D., Berns, H. G., Shiraishi, K. K., Thrane, E., Washburn, K., and Wilkes, R. J.

Subjects
High Energy Physics - Experiment
Abstract

A search for neutron-antineutron ($n-\bar{n}$) oscillation was undertaken in Super-Kamiokande using the 1489 live-day or $2.45 \times 10^{34}$ neutron-year exposure data. This process violates both baryon and baryon minus lepton numbers by an absolute value of two units and is predicted by a large class of hypothetical models where the seesaw mechanism is incorporated to explain the observed tiny neutrino masses and the matter-antimatter asymmetry in the Universe. No evidence for $n-\bar{n}$ oscillation was found, the lower limit of the lifetime for neutrons bound in ${}^{16}$O, in an analysis that included all of the significant sources of experimental uncertainties, was determined to be $1.9 \times 10^{32}$~years at the 90\% confidence level. The corresponding lower limit for the oscillation time of free neutrons was calculated to be $2.7 \times 10^8$~s using a theoretical value of the nuclear suppression factor of $0.517 \times 10^{23}$~s$^{-1}$ and its uncertainty., Comment: 8 pages, 2 figures

Published
2011
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21. Study of Non-Standard Neutrino Interactions with Atmospheric Neutrino Data in Super-Kamiokande I and II

Author

Mitsuka, G., Abe, K., Hayato, Y., Iida, T., Ikeda, M., Kameda, J., Koshio, Y., Miura, M., Moriyama, S., Nakahata, M., Nakayama, S., Obayashi, Y., Sekiya, H., Shiozawa, M., Suzuki, Y., Takeda, A., Takenaga, Y., Takeuchi, Y., Ueno, K., Ueshima, K., Watanabe, H., Yamada, S., Hazama, S., Higuchi, I., Ishihara, C., Kaji, H., Kajita, T., Kaneyuki, K., Nishino, H., Okumura, K., Tanimoto, N., Dufour, F., Kearns, E., Litos, M., Raaf, J. L., Stone, J. L., Sulak, L. R., Goldhaber, M., Bays, K., Cravens, J. P., Kropp, W. R., Mine, S., Regis, C., Smy, M. B., Sobel, H. W., Vagins, M. R., Ganezer, K. S., Hill, J., Keig, W. E., Jang, J. S., Kim, J. Y., Lim, I. T., Albert, J., Scholberg, K., Walter, C. W., Wendell, R., Ishizuka, T., Tasaka, S., Learned, J. G., Matsuno, S., Watanabe, Y., Hasegawa, T., Ishida, T., Ishii, T., Kobayashi, T., Nakadaira, T., Nakamura, K., Nishikawa, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Suzuki, A. T., Minamino, A., Nakaya, T., Yokoyama, M., Fukuda, Y., Itow, Y., Tanaka, T., Jung, C. K., Lopez, G., McGrew, C., Yanagisawa, C., Tamura, N., Idehara, Y., Sakuda, M., Kuno, Y., Yoshida, M., Kim, S. B., Yang, B. S., Okazawa, H., Choi, Y., Seo, H. K., Furuse, Y., Nishijima, K., Yokosawa, Y., Koshiba, M., Totsuka, Y., Chen, S., Liu, J., Heng, Y., Yang, Z., Zhang, H., Kielczewska, D., Connolly, K., Thrane, E., and Wilkes, R. J.

Subjects
High Energy Physics - Experiment
Abstract

In this paper we study non-standard neutrino interactions as an example of physics beyond the standard model using atmospheric neutrino data collected during the Super-Kamiokande I(1996-2001) and II(2003-2005) periods. We focus on flavor-changing-neutral-currents (FCNC), which allow neutrino flavor transitions via neutral current interactions, and effects which violate lepton non-universality (NU) and give rise to different neutral-current interaction-amplitudes for different neutrino flavors. We obtain a limit on the FCNC coupling parameter, varepsilon_{mu tau}, |varepsilon_{mu tau}|<1.1 x 10^{-2} at 90%C.L. and various constraints on other FCNC parameters as a function of the NU coupling, varepsilon_{e e}. We find no evidence of non-standard neutrino interactions in the Super-Kamiokande atmospheric data., Comment: 12 Pages, 14 figures. To be submitted to Phys. Rev. D

Published
2011
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22. Search for Differences in Oscillation Parameters for Atmospheric Neutrinos and Antineutrinos at Super-Kamiokande

Author

Collaboration, Super-Kamiokande, Abe, K., Hayato, Y., Iida, T., Ikeda, M., Iyogi, K., Kameda, J., Koshio, Y., Kozuma, Y., Miura, M., Moriyama, S., Nakahata, M., Nakayama, S., Obayashi, Y., Sekiya, H., Shiozawa, M., Suzuki, Y., Takeda, A., Takenaga, Y., Takeuchi, Y., Ueno, K., Ueshima, K., Watanabe, H., Yamada, S., Yokozawa, T., Ishihara, C., Kaji, H., Lee, K. P., Kajita, T., Kaneyuki, K., McLachlan, T., Okumura, K., Shimizu, Y., Tanimoto, N., Martens, K., Vagins, M. R., Labarga, L., Magro, L. M., Dufour, F., Kearns, E., Litos, M., Raaf, J. L., Stone, J. L., Sulak, L. R., Goldhaber, M., Bays, K., Kropp, W. R., Mine, S., Regis, C., Smy, M. B., Sobel, H. W., Ganezer, K. S., Hill, J., Keig, W. E., Jang, J. S., Kim, J. Y., Lim, I. T., Albert, J. B., Scholberg, K., Walter, C. W., Wendell, R., Wongjirad, T. M., Tasaka, S., Learned, J. G., Matsuno, S., Hasegawa, T., Ishida, T., Ishii, T., Kobayashi, T., Nakadaira, T., Nakamura, K., Nishikawa, K., Nishino, H., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Suzuki, A. T., Minamino, A., Nakaya, T., Fukuda, Y., Itow, Y., Mitsuka, G., Tanaka, T., Jung, C. K., Taylor, I., Yanagisawa, C., Ishino, H., Kibayashi, A., Mino, S., Mori, T., Sakuda, M., Toyota, H., Kuno, Y., Kim, S. B., Yang, B. S., Ishizuka, T., Okazawa, H., Choi, Y., Nishijima, K., Koshiba, M., Yokoyama, M., Totsuka, Y., Chen, S., Heng, Y., Yang, Z., Zhang, H., Kielczewska, D., Mijakowski, P., Connolly, K., Dziomba, M., and Wilkes, R. J.

Subjects
High Energy Physics - Experiment
Abstract

We present a search for differences in the oscillations of antineutrinos and neutrinos in the Super-Kamiokande -I, -II, and -III atmospheric neutrino sample. Under a two-flavor disappearance model with separate mixing parameters between neutrinos and antineutrinos, we find no evidence for a difference in oscillation parameters. Best fit antineutrino mixing is found to be at (dm2bar, sin2 2 thetabar) = (2.0x10^-3 eV^2, 1.0) and is consistent with the overall Super-K measurement., Comment: 6 pages, 4 figures. Figure updated

Published
2011
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23. High-resolution measurements of face-to-face contact patterns in a primary school

Author

Stehlé, J., Voirin, N., Barrat, A., Cattuto, C., Isella, L., Pinton, J. -F., Quaggiotto, M., Broeck, W. Van den, Régis, C., Lina, B., and Vanhems, P.

Subjects
Physics - Physics and Society, Computer Science - Social and Information Networks, Quantitative Biology - Quantitative Methods
Abstract

Little quantitative information is available on the mixing patterns of children in school environments. Describing and understanding contacts between children at school would help quantify the transmission opportunities of respiratory infections and identify situations within schools where the risk of transmission is higher. We report on measurements carried out in a French school (6-12 years children), where we collected data on the time-resolved face-to-face proximity of children and teachers using a proximity-sensing infrastructure based on radio frequency identification devices. Data on face-to-face interactions were collected on October 1st and 2nd, 2009. We recorded 77,602 contact events between 242 individuals. Each child has on average 323 contacts per day with 47 other children, leading to an average daily interaction time of 176 minutes. Most contacts are brief, but long contacts are also observed. Contacts occur mostly within each class, and each child spends on average three times more time in contact with classmates than with children of other classes. We describe the temporal evolution of the contact network and the trajectories followed by the children in the school, which constrain the contact patterns. We determine an exposure matrix aimed at informing mathematical models. This matrix exhibits a class and age structure which is very different from the homogeneous mixing hypothesis. The observed properties of the contact patterns between school children are relevant for modeling the propagation of diseases and for evaluating control measures. We discuss public health implications related to the management of schools in case of epidemics and pandemics. Our results can help define a prioritization of control measures based on preventive measures, case isolation, classes and school closures, that could reduce the disruption to education during epidemics.

Published
2011
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24. An Indirect Search for WIMPs in the Sun using 3109.6 days of upward-going muons in Super-Kamiokande

Author

Collaboration, The Super-Kamiokande, Tanaka, T., Abe, K., Hayato, Y., Iida, T., Kameda, J., Koshio, Y., Kouzuma, Y., Miura, M., Moriyama, S., Nakahata, M., Nakayama, S., Obayashi, Y., Sekiya, H., Shiozawa, M., Suzuki, Y., Takeda, A., Takenaga, Y., Ueno, K., Ueshima, K., Yamada, S., Yokozawa, T., Ishihara, C., Hazama, S., Kaji, H., Kajita, T., Kaneyuki, K., McLachlan, T., Okumura, K., Shimizu, Y., Tanimoto, N., Dufour, F., Kearns, E., Litos3, M., Raaf, J. L., Stone, J. L., Sulak, L. R., Cravens, J. P., Bays, K., Kropp, W. R., Mine, S., Regis, C., Smy, M. B., Sobel, H. W., Ganezer, K. S., Hill, J., Keig, W. E., Jang, J. S., Kim, J. Y., Lim, I. T., Albert, J. B., Scholberg, K., Walter, C. W., Wendell, R., Wongjirad, T., Ishizuka, T., Tasaka, S., Learned, J. G., Matsuno, S., Smith, S., Martens, K., Vagins, M., Watanabe, Y., Hasegawa, T., Ishida, T., Ishii, T., Kobayashi, T., Nakadaira, T., Nakamura, K., Nishikawa, K., Nishino, H., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Suzuki, A. T., Takeuchi, Y., Ikeda, M., Minamino, A., Nakaya, T., Labarga, L., Fukuda, Y., Itow, Y., Mitsuka, G., Jung, C. K., McGrew, C., Lopez, G., Yanagisawa, C., Tamura, N., Ishino, H., Kibayashi, A., Sakuda, M., Kuno, Y., Yoshida, M., Kim, S. B., Yang, B. S., Okazawa, H., Choi, Y., Nishijima, K., Yokosawa, Y., Koshiba, M., Totsuka, Y., Yokoyama, M., Chen, S., Heng, Y., Yang, Z., Zhang, H., Kielczewska, D., Mijakowski, P., Connolly, K., Dziomba, M., Thrane, E., and Wilkes, R. J.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment
Abstract

We present the result of an indirect search for high energy neutrinos from WIMP annihilation in the Sun using upward-going muon (upmu) events at Super-Kamiokande. Datasets from SKI-SKIII (3109.6 days) were used for the analysis. We looked for an excess of neutrino signal from the Sun as compared with the expected atmospheric neutrino background in three upmu categories: stopping, non-showering, and showering. No significant excess was observed. The 90% C.L. upper limits of upward-going muon flux induced by WIMPs of 100 GeV/c$^2$ were 6.4$\times10^{-15}$ cm$^{-2}$ sec$^{-1}$ and 4.0$\times10^{-15}$ cm$^{-2}$ sec$^{-1}$ for the soft and hard annihilation channels, respectively. These limits correspond to upper limits of 4.5$\times10^{-39}$ cm$^{-2}$ and 2.7$\times10^{-40}$ cm$^{-2}$ for spin-dependent WIMP-nucleon scattering cross sections in the soft and hard annihilation channels, respectively., Comment: Add journal reference. Also fixed typo and cosmetic things in the old draft

Published
2011
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25. Solar neutrino results in Super-Kamiokande-III

Author

Abe, K., Hayato, Y., Iida, T., Ikeda, M., Ishihara, C., Iyogi, K., Kameda, J., Kobayashi, K., Koshio, Y., Kozuma, Y., Miura, M., Moriyama, S., Nakahata, M., Nakayama, S., Obayashi, Y., Ogawa, H., Sekiya, H., Shiozawa, M., Suzuki, Y., Takeda, A., Takenaga, Y., Ueno, K., Ueshima, K., Watanabe, H., Yamada, S., Yokozawa, T., Hazama, S., Kaji, H., Kajita, T., Kaneyuki, K., McLachlan, T., Okumura, K., Shimizu, Y., Tanimoto, N., Vagins, M. R., Labarga, L., Magro, L. M, Dufour, F., Kearns, E., Litos, M., Raaf, J. L., Stone, J. L., Sulak, L. R., Wang, W., Goldhaber, M., Bays, K., Casper, D., Cravens, J. P., Kropp, W. R., Mine, S., Regis, C., Renshaw, A., Smy, M. B., Sobel, H. W., Ganezer, K. S., Hill, J., Keig, W. E., Jang, J. S., Kim, J. Y., Lim, I. T., Albert, J., Wendell, R., Wongjirad, T., Scholberg, K., Walter, C. W., Ishizuka, T., Tasaka, S., Learned, J. G., Matsuno, S., Watanabe, Y., Hasegawa, T., Ishida, T., Ishii, T., Kobayashi, T., Nakadaira, T., Nakamura, K., Nishikawa, K., Nishino, H., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Suzuki, A. T., Takeuchi, Y., Minamino, A., Nakaya, T., Fukuda, Y., Itow, Y., Mitsuka, G., Tanaka, T., Jung, C. K., Lopez, G., McGrew, C., Terri, R., Yanagisawa, C., Tamura, N., Ishino, H., Kibayashi, A., Mino, S., Mori, T., Sakuda, M., Toyota, H., Kuno, Y., Yoshida, M., Kim, S. B., Yang, B. S., Okazawa, H., Choi, Y., Nishijima, K., Yokosawa, Y., Koshiba, M., Totsuka, Y., Yokoyama, M., Chen, S., Heng, Y., Yang, Z., Zhang, H., Kielczewska, D., Mijakowski, P., Connolly, K., Dziomba, M., Thrane, E., and Wilkes, R. J.

Subjects
High Energy Physics - Experiment
Abstract

The results of the third phase of the Super-Kamiokande solar neutrino measurement are presented and compared to the first and second phase results. With improved detector calibrations, a full detector simulation, and improved analysis methods, the systematic uncertainty on the total neutrino flux is estimated to be ?2.1%, which is about two thirds of the systematic uncertainty for the first phase of Super-Kamiokande. The observed 8B solar flux in the 5.0 to 20 MeV total electron energy region is 2.32+/-0.04 (stat.)+/-0.05 (sys.) *10^6 cm^-2sec^-1, in agreement with previous measurements. A combined oscillation analysis is carried out using SK-I, II, and III data, and the results are also combined with the results of other solar neutrino experiments. The best-fit oscillation parameters are obtained to be sin^2 {\theta}12 = 0.30+0.02-0.01(tan^2 {\theta}12 = 0.42+0.04 -0.02) and {\Delta}m2_21 = 6.2+1.1-1.9 *10^-5eV^2. Combined with KamLAND results, the best-fit oscillation parameters are found to be sin^2 {\theta}12 = 0.31+/-0.01(tan^2 {\theta}12 = 0.44+/-0.03) and {\Delta}m2_21 = 7.6?0.2*10^-5eV^2 . The 8B neutrino flux obtained from global solar neutrino experiments is 5.3+/-0.2(stat.+sys.)*10^6cm^-2s^-1, while the 8B flux becomes 5.1+/-0.1(stat.+sys.)*10^6cm^-2s^-1 by adding KamLAND result. In a three-flavor analysis combining all solar neutrino experiments, the upper limit of sin^2 {\theta}13 is 0.060 at 95% C.L.. After combination with KamLAND results, the upper limit of sin^2 {\theta}13 is found to be 0.059 at 95% C.L.., Comment: 19 pages, 33 figures in the main text. The appendix section on errata is added in v3

Published
2010
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26. Atmospheric neutrino oscillation analysis with sub-leading effects in Super-Kamiokande I, II, and III

Author

Collaboration, Super-Kamiokande, Wendell, R., Ishihara, C., Abe, K., Hayato, Y., Iida, T., Ikeda, M., Iyogi, K., Kameda, J., Kobayashi, K., Koshio, Y., Kozuma, Y., Miura, M., Moriyama, S., Nakahata, M., Nakayama, S., Obayashi, Y., Ogawa, H., Sekiya, H., Shiozawa, M., Suzuki, Y., Takeda, A., Takenaga, Y., Takeuchi, Y., Ueno, K., Ueshima, K., Watanabe, H., Yamada, S., Yokozawa, T., Hazama, S., Kaji, H., Kajita, T., Kaneyuki, K., McLachlan, T., Okumura, K., Shimizu, Y., Tanimoto, N., Vagins, M. R., Dufour, F., Kearns, E., Litos, M., Raaf, J. L., Stone, J. L., Sulak, L. R., Wang, W., Goldhaber, M., Bays, K., Casper, D., Cravens, J. P., Kropp, W. R., Mine, S., Regis, C., Smy, M. B., Sobel, H. W., Ganezer, K. S., Hill, J., Keig, W. E., Jang, J. S., Kim, J. Y., Lim, I. T., Albert, J., Fechner, M., Scholberg, K., Walter, C. W., Tasaka, S., Learned, J. G., Matsuno, S., Watanabe, Y., Hasegawa, T., Ishida, T., Ishii, T., Kobayashi, T., Nakadaira, T., Nakamura, K., Nishikawa, K., Nishino, H., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Suzuki, A. T., Minamino, A., Nakaya, T., Fukuda, Y., Itow, Y., Mitsuka, G., Tanaka, T., Jung, C. K., Lopez, G., McGrew, C., Yanagisawa, C., Tamura, N., Ishino, H., Kibayashi, A., Mino, S., Mori, T., Sakuda, M., Toyota, H., Kuno, Y., Yoshida, M., Kim, S. B., Yang, B. S., Ishizuka, T., Okazawa, H., Choi, Y., Nishijima, K., Yokosawa, Y., Koshiba, M., Yokoyama, M., Totsuka, Y., Chen, S., Heng, Y., Yang, Z., Zhang, H., Kielczewska, D., Mijakowski, P., Connolly, K., Dziomba, M., Thrane, E., and Wilkes, R. J.

Subjects
High Energy Physics - Experiment
Abstract

We present a search for non-zero theta_{13} and deviations of sin^2 theta_{23} from 0.5 in the oscillations of atmospheric neutrino data from Super-Kamiokande -I, -II, and -III. No distortions of the neutrino flux consistent with non-zero theta_{13} are found and both neutrino mass hierarchy hypotheses are in agreement with the data. The data are best fit at Delta m^2 = 2.1 x 10^-3 eV^2, sin^2 theta_{13} = 0.0, and sin^2 theta_{23} =0.5. In the normal (inverted) hierarchy theta_{13} and Delta m^2 are constrained at the one-dimensional 90% C.L. to sin^2 theta_{13} < 0.04 (0.09) and 1.9 (1.7) x 10^-3 < Delta m^2 < 2.6 (2.7) x 10^-3 eV^2. The atmospheric mixing angle is within 0.407 <= sin^2 theta_{23} <= 0.583 at 90% C.L., Comment: 17 Pages, 14 figures. To be submitted to Phys. Rev. D Minor update to text after referee comments. Figures modified for better grayscale printing.

Published
2010
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29. INSTITUIÇÕES ESCOLARES: memórias e narrativas Coleção Instituições Escolares - Volume 1

Author

NASCIMENTO, NASCIMENTO, J. C., primary, FARIA, L. C. M., additional, SILVA JUNIOR, A. F., additional, CASINI, ADRIENA, additional, BALASSIANO, Ana Luiza Grillo, additional, CONCEIÇÃO, A. G., additional, MACHADO, Á. M. B., additional, REGIS, C. V., additional, PONTES, C. M., additional, DAVID, H. C. S., additional, SANTOS, H. H. M., additional, PINHEIRO JR., Jefte, additional, PISTILLI, J. C. T., additional, NASCIMENTO, J. C., additional, SANTOS, K. C. S., additional, BAROLDI, Karyne Alves, additional, SANTOS, K. C. S. M., additional, FONTANA, L. R., additional, and FERNANDES, MAURO, additional

Published
2020
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30. Antiproliferative potential of solidagenone isolated of Solidago chilensis

Author

Gomes, Denise B., Zanchet, Barbara, Locateli, Gelvani, Benvenutti, Régis C., Vechia, Cristian A. Dalla, Schönell, Amanda P., Diel, Kriptsan A.P., Zilli, Gabriela A.L., Miorando, Daniela, Ernetti, Jackeline, Oliveira, Bianca, Zanotelli, Patrícia, Santos, Maria F.C., Barisson, Andersson, Banzato, Thais P., Ruiz, Ana L.T.G., Carvalho, João E., Filho, Valdir Cechinel, García, Pablo A.G., Feliciano, Arturo San, and Roman, Walter A., Junior

Published
2018
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31. Anti-retroviral therapy after “Treat All” in Harare, Zimbabwe: What are the changes in uptake, time to initiation and retention? [version 2; peer review: 2 approved, 1 approved with reservations]

Author

Takura Matare, Hemant Deepak Shewade, Ronald T. Ncube, Kudzai Masunda, Innocent Mukeredzi, Kudakwashe C. Takarinda, Janet Dzangare, Gloria Gonese, Bekezela B. Khabo, Regis C. Choto, and Tsitsi Apollo

Subjects
Research Article, Articles, ART outcomes, test and treat, universal test and treat, time to treatment, HIV, SORT IT, Operational research
Abstract

Background: In Zimbabwe, Harare was the first province to implement “Treat All” for people living with human immunodeficiency virus (PLHIV). Since its roll out in July 2016, no study has been conducted to assess the changes in key programme indicators. We compared antiretroviral therapy (ART) uptake, time to ART initiation from diagnosis, and retention before and during “Treat All”. Methods: We conducted an ecological study to assess ART uptake among all PLHIV newly diagnosed before and during “Treat All”. We conducted a cohort study to assess time to ART initiation and retention in care among all PLHIV newly initiated on ART from all electronic patient management system-supported sites (n=50) before and during “Treat All”. Results: ART uptake increased from 65% (n=4619) by the end of quarter one, 2014 to 85% (n=5152) by the end of quarter four, 2018. A cohort of 2289 PLHIV was newly initiated on ART before (April-June 2015) and 1682 during “Treat all” (April-June 2017). Their age and gender distribution was similar. The proportion of PLHIV in early stages of disease was significantly higher during “Treat all” (73.2% vs. 55.6%, p Conclusion: Although there were benefits of early ART initiation during “Treat All”, the programme should consider strategies to improve retention.

Published
2020
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32. Anti-retroviral therapy after “Treat All” in Harare, Zimbabwe: What are the changes in uptake, time to initiation and retention? [version 1; peer review: 2 approved with reservations]

Author

Takura Matare, Hemant Deepak Shewade, Ronald T. Ncube, Kudzai Masunda, Innocent Mukeredzi, Kudakwashe C. Takarinda, Janet Dzangare, Gloria Gonese, Bekezela B. Khabo, Regis C. Choto, and Tsitsi Apollo

Subjects
Research Article, Articles, ART outcomes, test and treat, universal test and treat, time to treatment, HIV, SORT IT, Operational research
Abstract

Background: In Zimbabwe, Harare was the first province to implement “Treat All” for people living with human immunodeficiency virus (PLHIV). Since its roll out in July 2016, no study has been conducted to assess the changes in key programme indicators. We compared antiretroviral therapy (ART) uptake, time to ART initiation from diagnosis, and retention before and during “Treat All”. Methods: We conducted an ecological study to assess ART uptake among all PLHIV newly diagnosed before and during “Treat All”. We conducted a cohort study to assess time to ART initiation and retention in care among all PLHIV newly initiated on ART from all electronic patient management system-supported sites (n=50) before and during “Treat All”. Results: ART uptake increased from 65% (n=4619) by the end of quarter one, 2014 to 85% (n=5152) by the end of quarter four, 2018. A cohort of 2289 PLHIV were newly initiated on ART before (April-June 2015) and 1682 during “Treat all” (April-June 2017). Their age and gender distribution was similar. The proportion of PLHIV in early stages of disease was significantly higher during “Treat all” (73.2% vs. 55.6%, p Conclusion: Although there were benefits of early ART initiation during “Treat All”, the programme should consider strategies to improve retention.

Published
2020
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33. Dietary Intake of Adults Who Participate in CrossFit® Exercise Regimens

Author

Regis C. Pearson and Nathan T. Jenkins

Subjects
diet, CrossFit®, high-intensity functional training, food frequency questionnaire, Sports, GV557-1198.995
Abstract

Background: The combination of high-intensity aerobic and high-load resistance training, as in CrossFit®, exerts similar or superior benefits to other exercise modalities. This study aimed to assess dietary habits and characterize the nutritional goals, exercise habits, and clinical health outcomes of individuals who participate in CrossFit®. Methods: Adults who are 19 y or older, with >6 mo of CrossFit® participation, completed an electronic survey and the dietary health questionnaire III. In separate models, multiple stepwise linear regressions were performed to detect the associations between (i) dietary intake, (ii) exercise habits, (iii) clinical measures, and a priori selected predictors (sex, weight status, age, and exercise frequency) in each case. Odds ratios were detected between nutritional and fitness goals, clinical outcomes, and predictors. Results: In total, 449 respondents completed both questionnaires. Of these, 443 respondents were used for relative macronutrients assessment due to not reporting body weight. Dietary intake was associated with sex, weight status, age, exercise frequency, and nutritional goals. Nutritional and fitness goals and clinical outcomes were associated with sex, weight status, age, and exercise frequency. Conclusion: Nutritional goals are underlying factors that affect eating behaviors in non-competitive CrossFit® participants. It is imperative to consider the sex, age, exercise habits, and nutritional goals of CrossFit® participants when investigating and prescribing dietary outcomes.

Published
2022
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35. Effects of a 4-week pecan-enriched diet on cognitive function in healthy older adults

Author

Betsy Cogan, Regis C. Pearson, Chad M. Paton, Nathan T. Jenkins, and Jamie A. Cooper

Subjects
Nutrition and Dietetics, Medicine (miscellaneous), Biochemistry, Food Science
Abstract

BACKGROUND: Pecans are rich in nutrients known to benefit cognition. OBJECTIVE: To examine the effect of daily pecan consumption on cognitive function in older adults. METHODS: In this randomized controlled trial, 42 adults (50–75y) either consumed 68 g of pecans/day for 4-weeks (pecan; n = 21) or avoided all nuts (control; n = 21). At pre- (V1) and post-intervention (V2) visits, cognitive function was assessed using a fluid composite score and four subtests from the NIH Toolbox-Cognitive Battery (NIHTB-CB) (Flanker Test, Digital Change Card Sort Test (DCCS), Picture Sequence Memory Test (PSMT), NIHTB Auditory Verbal Learning Test (RAVLT)) at fasting, 30- and 210-min after a high-saturated fat meal void of pecans. RESULTS: From V1 to V2, fasting and postprandial cognitive performance did not differ between groups. There were improvements in both groups for fasting fluid composite score (p

Published
2022

36. Retention and predictors of attrition among patients who started antiretroviral therapy in Zimbabwe's national antiretroviral therapy programme between 2012 and 2015.

Author

Richard Makurumidze, Tsitsi Mutasa-Apollo, Tom Decroo, Regis C Choto, Kudakwashe C Takarinda, Janet Dzangare, Lutgarde Lynen, Wim Van Damme, James Hakim, Tapuwa Magure, Owen Mugurungi, and Simbarashe Rusakaniko

Subjects
Medicine, Science
Abstract

BACKGROUND:The last evaluation to assess outcomes for patients receiving antiretroviral therapy (ART) through the Zimbabwe public sector was conducted in 2011, covering the 2007-2010 cohorts. The reported retention at 6, 12, 24 and 36 months were 90.7%, 78.1%, 68.8% and 64.4%, respectively. We report findings of a follow-up evaluation for the 2012-2015 cohorts to assess the implementation and impact of recommendations from this prior evaluation. METHODS:A nationwide retrospective study was conducted in 2016. Multi-stage proportional sampling was used to select health facilities and study participants records. The data extracted from patient manual records included demographic, baseline clinical characteristics and patient outcomes (active on treatment, died, transferred out, stopped ART and lost to follow-up (LTFU)) at 6, 12, 24 and 36 months. The data were analysed using Stata/IC 14.2. Retention was estimated using survival analysis. The predictors associated with attrition were determined using a multivariate Cox regression model. RESULTS:A total of 3,810 participants were recruited in the study. The median age in years was 35 (IQR: 28-42). Overall, retention increased to 92.4% (p-value = 0.060), 86.5% (p-value

Published
2020
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38. Effect of Prior Exercise on Postprandial Lipemia: An Updated Meta-Analysis and Systematic Review

Author

Regis C, Pearson, Betsy, Cogan, Sara A, Garcia, and Nathan T, Jenkins

Subjects
Nutrition and Dietetics, Humans, Medicine (miscellaneous), Hyperlipidemias, Orthopedics and Sports Medicine, General Medicine, Postprandial Period, Energy Metabolism, Exercise, Triglycerides
Abstract

The purpose of this systematic review was to synthesize the results from current literature examining the effects of prior exercise on the postprandial triglyceride (TG) response to evaluate current literature and provide future direction. A quantitative review was performed using meta-analytic methods to quantify individual effect sizes. A moderator analysis was performed to investigate potential variables that could influence the effect of prior exercise on postprandial TG response. Two hundred and seventy-nine effects were retrieved from 165 studies for the total TG response and 142 effects from 87 studies for the incremental area under the curve TG response. There was a moderate effect of exercise on the total TG response (Cohen’s d = −0.47; p p p d = −0.40; p

Published
2022

39. Impact of aerobic fitness status, menstrual cycle phase, and oral contraceptive use on exercise substrate oxidation and metabolic flexibility in females.

Author

Olenick, Alyssa A., Pearson, Regis C., and Jenkins, Nathan T.

Subjects
*AEROBIC capacity, *ENERGY metabolism, *NEAR infrared spectroscopy, *SAMPLE size (Statistics), *ANALYSIS of variance, *MENSTRUAL cycle, *EFFECT sizes (Statistics), *PHYSICAL fitness, *EXERCISE physiology, *T-test (Statistics), *ORAL contraceptives, *EXERCISE intensity, *DESCRIPTIVE statistics, *RESEARCH funding, *HIGH-intensity interval training, *OXIDATION-reduction reaction, *CALORIMETRY
Abstract

The influence of menstrual cycle phase and fitness status on metabolism during high-intensity interval exercise (HIIE) was assessed. Twenty-five females (24.4 (3.6) years) were categorized by normal menstrual cycle (n = 14) vs. oral contraceptive (OC) use (n = 11) and by aerobic fitness, high-fitness females (HFF; n = 13) vs. low-fitness females (LFF; n = 12). HIIE was four sets of four repetitions with a 3 min rest between intervals on a cycle ergometer at a power output halfway between the ventilatory threshold and V̇O2peak and performed during follicular (FOL: days 2–7 or inactive pills) and luteal phases (LUT: day ∼21 or 3rd week of active pills). Substrate oxidation was assessed via indirect calorimetry, blood lactate via finger stick, and recovery of skeletal muscle oxidative metabolism (mV̇O2) via continuous-wave near-infrared spectroscopy. HFF oxidized more fat (g·kg−1) during the full session (FOL: p = 0.050, LUT: p = 0.001), high intervals (FOL: p = 0.048, LUT: p = 0.001), low intervals (FOL: p = 0.032, LUT: p = 0.024), and LUT recovery (p = 0.033). Carbohydrate oxidation area under the curve was greater in HFF during FOL (FOL: p = 0.049, LUT: p = 0.124). Blood lactate was lower in LFF in FOL (p ≤ 0.05) but not in LUT. Metabolic flexibility (Δ fat oxidation g·kg−1·min−1) was greater in HFF than LFF during intervals 2–3 in FOL and 1–4 in LUT (p ≤ 0.05). Fitness status more positively influences exercise metabolic flexibility during HIIE than cycle phase or OC use. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Metabolic response during high-intensity interval exercise and resting vascular and mitochondrial function in CrossFit participants

Author

Pearson, Regis C., Olenick, Alyssa A., Jenkins, Nathan T., Pearson, Regis C., Olenick, Alyssa A., and Jenkins, Nathan T.

Abstract

High-intensity functional training (HIFT) can play a major role in preventing cardiometabolic disease. The majority of HIFT interventions incorporate CrossFit (CF) training. We measured aerobic capacity, metabolic response during high-intensity interval exercise (HIIE), resting mitochondrial oxidative capacity, and resting vascular function in adults who participated in CF training (> one year) vs. a sedentary group completing <2 h·wk-1 of structure exercise for > one year (SED). Twenty-one participants were recruited (CF n = 13 vs. SED n = 8). CF participants had a 33.0% greater relative VO2 peak (p<.001) and lower body fat percentage (CF = 18.6 [3.8] vs. SED = 30.3 [8.4]; p<.001). CF participants had higher exercising substrate oxidation when expressed as absolute and body weight relative values (p<.013), but not when expressed relative to lean mass (p>.200). CF participants had greater mitochondrial oxidative capacity (p=.014). There were no differences in large artery function, but CF participants had greater baseline arterial diameter (p=.004) and faster reperfusion following arterial occlusion (p<.05). These data support HIFT programs’ effectiveness in improving fitness, weight status, and metabolic, mitochondrial, and vascular function.

Published
2023

42. Training Status Impacts Metabolic Response to A High-Protein Weight Loss Diet in Recreationally Resistance-Trained Females

Author

OLENICK, ALYSSA A., PEARSON, REGIS C., and JENKINS, NATHAN T.

Subjects
Original Research
Abstract

This study investigated the effects of a novel high-protein diet template on postprandial metabolism and body composition (e.g., waist and hip circumference, body fat (%), fat mass, fat-free mass) in recreationally resistance-trained females. Fifteen females adhered to an eight-week high-protein dietary intervention (~1.5–1.6 g·kg(−1)·day(−1)) administered via template format. Pre- and post-intervention visits included anthropometrics, measurement of body composition, and an acute high-fat meal challenge. The high-fat meal challenge (61% fat) consisted of fasting postprandial blood glucose, resting metabolic rate (RMR), fat and carbohydrate oxidation assessed at 60-, 120-, and 180-minutes. Participants were split into high (HTF; 5–6 days·week(−1) of resistance training; n = 8) and low-training frequency (LTF; 2–3 days·week(−1) of resistance training; n = 7) groups. All metabolism data were assessed as absolute (kcal or g) and relative (kcal or g·kg·FFM(−1)·minutes(−1)) to fat-free mass. Post-intervention, there was a significant reduction in HTF waist circumference (p = 0.044), LTF body fat % (p = 0.012), and LTF fat mass (p = 0.014). Post-intervention, HTF females had significantly lower absolute RMR area under the curve (AUC) than LTF females (p = 0.036). LTF females had higher absolute fat oxidation AUC compared to HTF females’ pre-intervention (p = 0.048) but a significant decrease in absolute (p = 0.050) and relative (p = 0.050) fat oxidation AUC post-intervention. LTF females had a significant increase in absolute (p = 0.032) and relative (p = 0.029) carbohydrate oxidation AUC pre- to post-intervention (p = 0.032). For blood glucose, no significant differences between groups were detected (p > 0.05). These findings suggest that a novel high-protein diet template elicits a metabolic shift favoring carbohydrate oxidation in females engaging in low-frequency resistance training but did not alter fat and carbohydrate metabolism in females engaging in HTF resistance training.

Published
2023

45. Comparison of aspartame- and sugar-sweetened soft drinks on postprandial metabolism

Author

Nathan T. Jenkins, Edward S. Green, Alyssa A. Olenick, and Regis C. Pearson

Subjects
Meal, Nutrition and Dietetics, Triglyceride, Aspartame, Chemistry, digestive, oral, and skin physiology, Medicine (miscellaneous), General Medicine, Carbohydrate metabolism, chemistry.chemical_compound, Postprandial, Blood pressure, Ingestion, Resting energy expenditure, Food science
Abstract

Aim: We compared the impact of artificially- and sugar-sweetened beverages co-ingested with a mixed meal on postprandial fat and carbohydrate oxidation, blood glucose, and plasma insulin and triglyceride concentrations. Methods: Eight college-aged, healthy males completed three randomly assigned trials, which consisted of a mixed macronutrient meal test with 20oz of Diet-Coke (AS), Coca-Cola (NS), or water (CON). One week separated each trial and each participant served as his own control. Resting energy expenditure (REE) via indirect calorimetry, blood pressure, and blood samples were obtained immediately before, 5, 10, 30, 60, 120, and 180 min after meal and beverage ingestion. A two-way (treatment × time) repeated-measures ANOVA was conducted to assess REE, fat and carbohydrate oxidation rates, blood glucose, and plasma insulin and triglyceride concentrations. Results: There was a significant main effect of treatment on total fat oxidation (P = 0.006), fat oxidation was significantly higher after AS (P = 0.006) and CON (P = 0.001) compared to following NS. There was a significant main effect of treatment on total carbohydrate oxidation (P = 0.005), carbohydrate oxidation was significantly lower after AS (P = 0.014) and CON (P = 0.001) compared to following NS. Plasma insulin concentration AUC was significantly lower after AS (P = 0.019) and trended lower in CON (P = 0.054) compared to following NS. Conclusion: Ingestion of a mixed meal with an artificially-sweetened beverage does not impact postprandial metabolism, whereas a sugar-sweetened beverage suppresses fat oxidation and increases carbohydrate oxidation compared to artificially-sweetened beverage and water.

Published
2021

46. African American Females Are Less Metabolically Flexible Compared with Caucasian American Females following a Single High-Fat Meal: A Pilot Study

Author

Alyssa A. Olenick, Regis C. Pearson, Nuha Shaker, Maire M. Blankenship, Rachel A. Tinius, Lee J. Winchester, Evie Oregon, and Jill M. Maples

Subjects
Blood Glucose, Health, Toxicology and Mutagenesis, Interleukin-8, Public Health, Environmental and Occupational Health, Pilot Projects, Postprandial Period, Lipids, metabolic flexibility, African American, inflammation, high-fat meal, Black or African American, Glucose, Adipose Tissue, Humans, Insulin, Female, Triglycerides
Abstract

The relationship between metabolic flexibility (MF) and components of metabolic disease has not been well-studied among African American (AA) females and may play a role in the higher incidence of chronic disease among them compared with Caucasian American (CA) females. This pilot study aimed to compare the metabolic response of AA and CA females after a high-fat meal. Eleven AA (25.6 (5.6) y, 27.2 (6.0) kg/m2, 27.5 (9.7) % body fat) and twelve CA (26.5 (1.5) y, 25.7 (5.3) kg/m2, 25.0 (7.4) % body fat) women free of cardiovascular and metabolic disease and underwent a high-fat meal challenge (55.9% fat). Lipid oxidation, insulin, glucose, and interleukin (IL)-8 were measured fasted, 2 and 4 h postprandial. AA females had a significantly lower increase in lipid oxidation from baseline to 2 h postprandial (p = 0.022), and trended lower at 4 h postprandial (p = 0.081) compared with CA females, indicating worse MF. No group differences in insulin, glucose or HOMA-IR were detected. IL-8 was significantly higher in AA females compared with CA females at 2 and 4 h postprandial (p = 0.016 and p = 0.015, respectively). These findings provide evidence of metabolic and inflammatory disparities among AA females compared with CA females that could serve as a predictor of chronic disease in individuals with a disproportionately higher risk of development.

Published
2022
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50. High-fat meal increases peripheral blood mononuclear cell pro-inflammatory cytokine expression in African-American women

Author

Nuha Shaker, Jill M. Maples, Maire M. Blankenship, Evie Oregon, Alyssa Olenick, Rachel A. Tinius, Regis C Pearson, and Lee J. Winchester

Subjects
Adult, Adolescent, Physiology, Endocrinology, Diabetes and Metabolism, Interleukin-1beta, Gene Expression, Kentucky, Inflammation, 030204 cardiovascular system & hematology, Peripheral blood mononuclear cell, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Humans, Medicine, RNA, Messenger, 030304 developmental biology, African american, 0303 health sciences, Nutrition and Dietetics, Metabolic function, Interleukin-6, Tumor Necrosis Factor-alpha, business.industry, Interleukin-8, High fat meal, Cytokine expression, General Medicine, Metabolism, Middle Aged, Postprandial Period, Dietary Fats, Black or African American, Postprandial, Immunology, Leukocytes, Mononuclear, Cytokines, Female, medicine.symptom, business
Abstract

African-American (AA) women have elevated predominance of inflammatory diseases concurrent with local inflammation resulting in compromised metabolic function. The purpose of the study was 2-fold: 1) to examine the gene and protein expression of pro- and anti-inflammatory cytokine secretion by peripheral blood mononuclear cells (PBMC) obtained from AA and Caucasian-American (CA) women in response to an acute high-fat meal; and 2) to explore the influence of race (AA vs. CA) on PBMC reactivity. Ten AA and 11 CA women consumed a high-fat meal with baseline and 4 h postprandial venous blood draws. PBMCs were incubated for 3 h then messenger RNA expression and supernatant protein concentration was used to examine inflammatory profiles. All women had a postprandial increase in interleukin (IL)-8 gene expression, IL-8 protein concentration, and tumor necrosis factor alpha (TNF-α) protein concentration (P < 0.05). AA women had a postprandial increase in IL-6, IL-8, and TNF-α protein concentration (P < 0.05). AA women had higher postprandial IL-1β protein concentration and IL-8 gene expression compared with CA women (P < 0.05). Our data uncovers the specific impact of race and time on pro-inflammatory PBMC (IL-1β, IL-6, IL-8, and TNF-α) expression profiles in response to an acute high-fat meal challenge. Novelty: African Americans have higher predominance of inflammatory disease. We explored the potential race impact on peripheral blood mononuclear cell reactivity in response to a meal. A pro-inflammatory response to an acute high-fat meal with race impact was observed possibly contributing to health disparities impacting African-American women.

Published
2021

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