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We describe the epidemiology of cancer after kidney transplantation (KTx), investigating its risk factors and impact on therapeutic management and survival in KTx recipients (KTRs). The association between modification of immunosuppressive (IS) therapy after cancer and survival outcomes was analyzed. We collected data from 930 KTRs followed for 7 [1–19] years. The majority of KTRs received KTx from a deceased donor (84%). In total, 74% of patients received induction therapy with basiliximab and 26% with ATG. Maintenance therapy included steroids, calcineurin inhibitors, and mycophenolate. Patients with at least one cancer (CA+) amounted to 19%. NMSC was the most common tumor (55%). CA+ were older and had a higher BMI. Vasculitis and ADPKD were more prevalent in CA+. ATG was independently associated with CA+ and was related to earlier cancer development in survival and competing risk analyses (p = 0.01 and

Photovoice is a participatory action research (PAR) method that employes photographic language to explore individuals’ stories and living contexts. This study explores the representations of young participants, both immigrants and non-immigrants, concerning integration—defined within Berry’s (1997) framework as a bidirectional process of cultural and social adaptation between migrants and host communities—and the lack of integration within their neighborhood in Reggio Emilia, Italy. The participants included 12 young individuals (6 migrants and 6 locals) aged 19 to 29, two peer researchers, and one researcher. Over the course of two weekly three-hour meetings, participants captured and discussed photos depicting their perspectives on integration. The findings highlighted diverse conceptualizations of integration. Participants emphasized the reciprocal relationship between migrants and locals, illustrating how positive interactions with schools, workplaces, and public spaces facilitate integration. Additionally, successful migrants were seen as models of empowerment. Conversely, themes such as poverty, loneliness, discrimination, and the impact of war emerged as significant barriers to integration. This study underscores the dynamic and interactive nature of integration, as experienced by young people in multicultural settings. It highlights how Photovoice methodology can effectively capture nuanced perspectives on integration, foster mutual understanding, and facilitate intergroup relationships. The method fosters personal and community reflection, actively engaging its audience in critical discussions about integration.

This study aims to determine the effect of workload on employee job satisfaction at Class IIB Correctional Institution Cilacap. This research uses quantitative and non-probability techniques by applying a saturated sampling of 61 people. The data collection technique was carried out using the distribution of questionnaires to respondents through Google Forms. There are 24 statement items that are used as indicators in the study. The data analysis technique used is through the normality test, simple linear regression test, significance test, and determination test processed using IBM SPSS software version 27. The results showed that there is an influence of workload on job satisfaction. The results of the determination test were obtained with an R Square value of 0.114 which indicates that the workload variable has an influence of 11.4% on the work satisfaction variable, while other variables influence the remaining 88.6%. Keywords: Workload; Job Satisfaction; Correctional Officers

Cryptocurrencies and their underlying technologies such as blockchains and smart contracts are rapidly gaining traction in sectors such as banking, identity management, supply chain management, cloud-computing, voting, forecasting, and so forth. With this change in visibility and first signs of mainstream adoption, there is a growing interest in understanding the cryptocurrency ecosystem, e.g., regarding market trends or inherent risks. Interestingly, however, spatial and platial aspects have not yet received much attention. One possible reason for this lack of analysis may be due to the perception of cryptocurrencies being global and living outside of legal frameworks. We will show that this is a misconception and that understanding the cryptocurrency ecosystem requires looking at the spaces and places involved in their creation, consumption, and regulation.

Background: Human kidneys are an important target of SARS-CoV-2 infection, and many renal abnormalities have been found in patients with SARS-CoV-2 infection, including proteinuria, hematuria, and acute kidney injury. Acute kidney injury is now considered a common complication of COVID-19, and the epidemiology of AKI in SARS-CoV-2-infected patients continues to be controversial. Aim and Methods: We have carried out a narrative review to evaluate the frequency and risk factors for AKI among patients hospitalized due to COVID-19, and the latest surveys on this topic have been included. The mechanisms by which AKI occurs in COVID-19 patients have also been reviewed. Results: Multiple risk factors for the development of AKI in patients with SARS-CoV-2 infection have been identified; these have been classified in various groups (management and background factors, among others). SARS-CoV-2 targets the kidneys by indirect activity, but SARS-CoV-2 infects tubular epithelial cells and podocytes. We retrieved 24 reports (n = 502,593 unique patients with SARS-CoV-2 infection) and found an incidence of AKI of 31.8% (range, 0.5% to 56.9%). Only a minority (n = 2) of studies had a prospective design. We found that the AKI risk was greater in SARS-CoV-2 patients who underwent in-hospital deaths vs. those who survived; the summary estimate of the unadjusted RR of AKI was 2.63 (95% CI, 2.37; 2.93) (random-effects model). A stratified analysis showed that the incidence of AKI was greater in those reports where the frequency of COVID-19-positive patients having comorbidities (diabetes mellitus, arterial hypertension, and advanced age) was high. The unadjusted relative risk (aRR) of AKI was greater in SARS-CoV-2 patients who underwent ICU admission vs. those who did not; the pooled estimate of AKI risk was 2.64 (95% CI, 1.96; 3.56) according to the random-effects model. Conclusions: AKI is a common complication of hospitalized SARS-CoV-2-infected patients, and some comorbidities are important risk factors for it. The direct activity of the virus on the kidneys has been mentioned in the pathogenesis of AKI in SARS-CoV-2 patients. Further studies are ongoing in order to identify the mechanisms underlying the kidney injury in this population. The role of AKI on survival in SARS-CoV-2-infected patients is another area of active investigation.

IntroductionRespiratory diseases such as chronic obstructive pulmonary disease, obstructive sleep apnea syndrome, and COVID-19 may cause a decrease in arterial oxygen saturation (SaO2). The continuous monitoring of oxygen levels may be beneficial for the early detection of hypoxemia and timely intervention. Wearable non-invasive pulse oximetry devices measuring peripheral oxygen saturation (SpO2) have been garnering increasing popularity. However, there is still a strong need for extended and robust clinical validation of such devices, especially to address topical concerns about disparities in performances across racial groups. This prospective clinical validation aimed to assess the accuracy of the reflective pulse oximeter function of the EmbracePlus wristband during a controlled hypoxia study in accordance with the ISO 80601-2-61:2017 standard and the Food & Drug Administration (FDA) guidance.MethodsHealthy adult participants were recruited in a controlled desaturation protocol to reproduce mild, moderate, and severe hypoxic conditions with SaO2 ranging from 100% to 70% (ClinicalTrials.gov registration #NCT04964609). The SpO2 level was estimated with an EmbracePlus device placed on the participant's wrist and the reference SaO2 was obtained from blood samples analyzed with a multiwavelength co-oximeter.ResultsThe controlled hypoxia study yielded 373 conclusive measurements on 15 subjects, including 30% of participants with dark skin pigmentation (V–VI on the Fitzpatrick scale). The accuracy root mean square (Arms) error was found to be 2.4%, within the 3.5% limit recommended by the FDA. A strong positive correlation between the wristband SpO2 and the reference SaO2 was observed (r = 0.96, P

Background Personal values have been extensively found to be relevant variables linked to prosociality; they are desirable and trans-situational goals that serve as guiding principles in people’s lives to select modes, means and actions, these reflecting what people consider relevant and worthy. Research has investigated how cultural background influences people’s personal values and prosociality, but little is known about the influence of the perception of the values en-dorsed by significant others, namely the people belonging to the micro-relational context with whom daily interac-tions and exchanges are possible. Based on Schwartz’s theory of basic human values, we analyzed the moderating role of the perceptions of significant others’ values in the relationship between personal values and self-reported prosociality. Participants and procedure Two hundred and forty-five Italian young adults (66.9% women) aged between 18 and 30 years (M = 22.58, SD = 2.53) completed a self-report questionnaire. Results Specifically, openness to change values were a significant positive predictor of self-reported prosociality when re-spondents perceived low importance assigned both to openness to change and self-transcendence by significant oth-ers, whereas conservation values were a significant positive predictor of self-reported prosociality when respondents perceived low importance assigned to self-enhancement by significant others. Conclusions Our findings show a complex interplay between personal values and perceived significant others’ values in shaping young adults’ self-reported prosociality.

PurposeWe studied the association between parathormone (PTH) levels and long-term graft loss in RTx patients (RTx-p).MethodsWe retrospectively evaluated 871 RTx-p, transplanted in our unit from Jan-2004 to Dec-2020 assessing renal function and mineral metabolism parameters at 1, 6, and 12 months after RTx. Graft loss and death with functioning graft during follow-up (FU, 8.3[5.4–11.4] years) were checked.ResultsAt month-1, 79% had HPT, of which 63% with secondary HPT (SHPT) and 16% tertiary HPT (THPT); at month-6, HPT prevalence was 80% of which SHPT 64% and THPT 16%; at month-12 HPT prevalence was 77% of which SHPT 62% and THPT 15%. A strong significant correlation was found between HPT type, PTH levels and graft loss at every time point. Mean PTH exposure remained strongly and independently associated to long term graft loss (OR 3.1 [1.4–7.1], p = 0.008). THPT was independently associated with graft loss at month-1 when compared to HPT absence and at every time point when compared to SHPT. No correlation was found with RTx-p death. Discriminatory analyses identified the best mean PTH cut-off to predict long-term graft loss to be between 88.6 and 89.9 pg/mL (AUC = 0.658). Cox regression analyses highlighted that THPT was strongly associated with shorter long-term graft survival at every time-point considered.ConclusionHigh PTH levels during 1st year of RTx seem to be associated with long term graft loss.

IntroductionHuman anelloviruses, including torque teno virus (TTV) and torque teno mini virus (TTMV), are ubiquitous in the general population and have no known pathogenicity. We investigated the prevalence and viral load of TTV and TTMV in plasma and saliva over pregnancy, and assessed their association with spontaneous or medically indicated preterm birth.MethodsThis is a secondary analysis of the Measurement of Maternal Stress (MOMS) study, which recruited 744 individuals with singleton pregnancies from 4 US sites (Chicago, Pittsburgh, San Antonio, and rural Pennsylvania). Baseline outpatient visits took place in the second trimester (between 12′0 and 20′6/7 weeks’ gestation), and follow-up visits in the third trimester (between 32′0 and 35′6/7 weeks’ gestation). In a case-control study design, participants who delivered preterm (

Objective: This study aimed to assess whether population‐level patterns in seizure occurrence previously observed in self‐reported diaries, medical records, and electroencephalographic recordings were also present in tonic–clonic seizure (TCS) diaries produced via the combined input of a US Food and Drug Administration‐cleared wristband with an artificial intelligence detection algorithm and patient self‐reports. We also investigated the characteristics of patient interactions with wearable seizure alerts. Methods: We analyzed wristband data from patients with TCSs who had at least three reported TCSs over a minimum of 90 days. We quantified TCS frequency and cycles, and the relationship between the mean and variability of monthly TCS counts. We also assessed interaction metrics such as false alarm dismissal and seizure confirmation rates. Results: Applying strict criteria for usable data, we reviewed 137 490 TCSs from 3012 patients, with a median length of TCS alert records of 445 days (range = 90–1806). Analyses showed consistency between prior diary studies and the present data concerning (1) the distribution of monthly TCS frequency (median = 3.1, range =.08–26); (2) the linear relationship (slope =.79, R2 =.83) between the logarithm of the mean and the logarithm of the SD of monthly TCS frequency (L‐relationship); and (iii) the prevalence of multiple coexisting seizure cycles, including circadian (84.0%), weekly (24.6%), and long‐term cycles (31.1%). Significance: Key population‐level patterns in seizure occurrence are recapitulated in wrist‐worn device recordings, supporting their validity for tracking TCS burden. Compared to other approaches, wearables can provide noninvasive, objective, long‐term data, revealing cycles in seizure risk. However, improved patient engagement with wristband alerts and further validation of detection accuracy in ambulatory settings are needed. Together, these findings suggest that data from smart wristbands may be used to derive features of TCS records and, ultimately, facilitate remote monitoring and the development of personalized forecasting tools for TCS management. Our findings may not generalize to other types of seizures. [ABSTRACT FROM AUTHOR]

Photovoice is a participatory action research (PAR) method that employes photographic language to explore individuals' stories and living contexts. This study explores the representations of young participants, both immigrants and non-immigrants, concerning integration—defined within Berry's (1997) framework as a bidirectional process of cultural and social adaptation between migrants and host communities—and the lack of integration within their neighborhood in Reggio Emilia, Italy. The participants included 12 young individuals (6 migrants and 6 locals) aged 19 to 29, two peer researchers, and one researcher. Over the course of two weekly three-hour meetings, participants captured and discussed photos depicting their perspectives on integration. The findings highlighted diverse conceptualizations of integration. Participants emphasized the reciprocal relationship between migrants and locals, illustrating how positive interactions with schools, workplaces, and public spaces facilitate integration. Additionally, successful migrants were seen as models of empowerment. Conversely, themes such as poverty, loneliness, discrimination, and the impact of war emerged as significant barriers to integration. This study underscores the dynamic and interactive nature of integration, as experienced by young people in multicultural settings. It highlights how Photovoice methodology can effectively capture nuanced perspectives on integration, foster mutual understanding, and facilitate intergroup relationships. The method fosters personal and community reflection, actively engaging its audience in critical discussions about integration. [ABSTRACT FROM AUTHOR]

The idea for this Special Issue emerged from the Editors’ collaboration on the framework of the European project MIMY: EMpowerment through liquid Integration of Migrant Youth in vulnerable conditions [...]

The article explores the reasons and the rationale behind the framework collective agreement on industrial relations reached by Amazon and the trade unions in Italy on September 15, 2021 - the first ever nation-wide collective agreement signed by the e-commerce giant in the world. Through a comparative perspective, this unique and largely unexpected event is interpreted in the light of the specific features of the Italian industrial relations system: a system still characterised by a low level of institutionalisation lacking formalized and stable rules governing relations between the actors, but in which such actors –especially the trade unions – have consolidated over time their organizational capacity and ability to mobilize their represented. These features may indeed facilitate innovation under favourable circumstances, as it happened in a period of rapid expansion of the multinational and of growing perception therefore of the need to maintain social peace and preserve its reputation as responsible organization. The main strengths and weaknesses of the agreement are finally discussed.

We describe the epidemiology of cancer after kidney transplantation (KTx), investigating its risk factors and impact on therapeutic management and survival in KTx recipients (KTRs). The association between modification of immunosuppressive (IS) therapy after cancer and survival outcomes was analyzed. We collected data from 930 KTRs followed for 7 [1--19] years. The majority of KTRs received KTx from a deceased donor (84%). In total, 74% of patients received induction therapy with basiliximab and 26% with ATG. Maintenance therapy included steroids, calcineurin inhibitors, and mycophenolate. Patients with at least one cancer (CA+) amounted to 19%. NMSC was the most common tumor (55%). CA+ were older and had a higher BMI. Vasculitis and ADPKD were more prevalent in CA+. ATG was independently associated with CA+ and was related to earlier cancer development in survival and competing risk analyses (p = 0.01 and <0.0001; basiliximab 89 ± 4 vs. ATG 40 ± 4 months). After cancer diagnosis, a significant prognostic impact was derived from the shift to mTOR inhibitors compared to a definitive IS drug suspension (p = 0.004). Our data confirm the relevance of cancer as a complication in KTRs with ATG as an independent risk factor. An individualized choice of IS to be proposed at the time of KTx is crucial in the prevention of neoplastic risk. Finally, switching to mTORi could represent an important strategy to improve patient survival. [ABSTRACT FROM AUTHOR]