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2. Mid- and long-term atrio-ventricular mechanics in children after recovery from asymptomatic or mildly symptomatic SARS-CoV-2 infection

Author

Sabatino, J, primary, Sirico, D, additional, Di Chiara, C, additional, Pogacnik, P, additional, Di Candia, A, additional, Bonfante, F, additional, Dona, D, additional, Costenaro, P, additional, Fumanelli, J, additional, Reffo, E, additional, Castaldi, B, additional, Biffanti, R, additional, Cerutti, A, additional, Giaquinto, C, additional, and Di Salvo, G, additional

Published
2022
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3. P154 EVOLUTION OF ECHOCARDIOGRAPHIC AND CARDIAC MRI ABNORMALITIES DURING FOLLOW–UP IN PATIENTS WITH PREVIOUS MIS–C DIAGNOSIS

Author

Sirico, D, Basso, A, Sabatino, J, Reffo, E, Cavaliere, A, Biffanti, R, Cerutti, A, Castaldi, B, Zulian, F, Da Dalt, L, and Di Salvo, G

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Background Cardiovascular manifestations in the acute phase of MIS–C are frequent. However, there is lacking evidence regarding late cardiological follow–up of this cohort of patients. The aim of our study was to describe the early and late cardiac abnormalities in patients with MIS–C, assessed by standard echocardiography (TTE), speckle tracking echocardiography (STE), and cardiac MRI (CMR). Materials and Methods 32 consecutive patients with confirmed MIS–C diagnosis were enrolled in this study. Clinical, laboratory and microbiological data were collected for all patients. At disease onset, all children underwent standard transthoracic echocardiography, STE with analysis of left ventricle global longitudinal strain (GLS) and 23 (75%) of them performed CMR. Patients underwent complete cardiological evaluation, including echocardiography and STE at two months (T1) and six months (T2) after diagnosis. CMR was repeated at six months after diagnosis. Results Mean age was 8.25±4years (range 1.3–17.7). Cardiovascular symptoms were present in 45.8% of cases. Thirteen children (40.6%) shared Kawasaki Disease–like symptoms, and 5 (15.6%) needed ICU admission. All patients showed an hyperinflammatory state. Tn–I was elevated in 20 (62.5%) and BNP in 28 (87.5%) patients. Median time to STE evaluation was 7 days and to CMR 18 days since fever onset. Mean LVEF at baseline was 58.8±10% with 10 patients (31%) below 55%. STE showed reduced mean LV GLS (–17.4±4%). Coronary dilation was observed in 9 (28,1%) patients. On CMR, LGE with nonischemic pattern was evident in 8/23 patients (35%). Median time to T1 and T2 evaluation was respectively 48.5 and 207 days. Follow–up data showed statistically significant improvement in left ventricular systolic function compared to acute phase. LVEF improved rapidly at T1 (62.5 ± 7.5 vs. 58.8±10.6%, p value 0.044) with only three patients (10%) below ≤ 55% at T1 and one patient (4%) at T2. LV GLS remained impaired at T1 (–17.2 ± 2.7 vs.–17.4 ± 4, p value 0.71), and significantly improved at T2 (–19±2.6% vs. –17.4±4%, p value 0.009). LV GLS was impaired (>–18%) in 53% of patients at baseline and T1, while only 13% showed LV GLS reduction at T2. CMR, performed 6 months after diagnosis, showed LGE persistence in 33.4% of cases. Conclusions Even though, early cardiac involvement significantly improves during follow–up, subclinical myocardial damage seems to be still detectable 6 months follow up in one third of MIS–C patients.

Published
2022

7. Correction to: Left ventricle longitudinal strain alterations in asymptomatic or mildly symptomatic pediatric patients with recent SARS-CoV-2 infection

Author

Sirico, D, primary, Costenaro, P, additional, Di Chiara, C, additional, Dona”, D, additional, Cozzani, S, additional, Fumanelli, J, additional, Di Candia, A, additional, Biffanti, R, additional, Cerutti, A, additional, Reffo, E, additional, Castaldi, B, additional, Da Dalt, L, additional, Giaquinto, C, additional, and Di Salvo, G, additional

Published
2022
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9. Exercise stress echocardiography in paediatric and adolescent patients

Author

Avesani, M, primary, Calvo, G, additional, Sabatino, J, additional, Sirico, D, additional, Castaldi, B, additional, Reffo, E, additional, Cerutti, A, additional, Biffanti, R, additional, Borrelli, N, additional, Piccinelli, E, additional, Fraisse, A, additional, Padalino, M, additional, Vida, V, additional, and Di Salvo, G, additional

Published
2022
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10. Exercise stress echocardiography in children and teenagers with congenital heart diseases

Author

Avesani, M, primary, Calvo, G, additional, Sirico, D, additional, Castaldi, B, additional, Reffo, E, additional, Cerutti, A, additional, Biffanti, R, additional, Di Candia, A, additional, Sabatino, J, additional, Borrelli, N, additional, Piccinelli, E, additional, Fraisse, A, additional, Padalino, M, additional, Vida, V, additional, and Di Salvo, G, additional

Published
2021
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13. Left ventricle longitudinal strain alterations in asymptomatic or mildly symptomatic pediatric patients with recent SARS-CoV-2 infection

Author

Sirico, D, Costenaro, P, Di Chiara, C, Dona\\', D, Cozzani, S, Fumanelli, J, Di Candia, A, Biffanti, R, Cerutti, A, Reffo, E, Castaldi, B, Da Dalt, L, Giaquinto, C, and Di Salvo, G

Subjects
AcademicSubjects/MED00200, Radiology, Nuclear Medicine and imaging, General Medicine, Tissue Doppler, Speckle Tracking and Strain Imaging, Cardiology and Cardiovascular Medicine
Abstract

Funding Acknowledgements Type of funding sources: This work has been partially supported by the ORCHESTRA project, H2020 Grant Agreement Number 101016167. Background Evidence suggests that clinical manifestations of children’s COVID-19 may be less severe. However, it has been described the pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) which resembles other inflammatory conditions (i.e. Kawasaki disease). Patients affected by PIMS-TS showed cardiac involvement with myocardial injury, reduced left ventricle systolic function and coronary artery abnormalities. Little is known regarding cardiac involvement in pediatric patients with asymptomatic or mildly symptomatic SARS-CoV-2 infection. Methods We analyzed 23 pediatric patients (13males, 56%) with diagnosis of SARS-CoV-2 infection based on PCR analysis of nasopharingeal swab (NPS), and asymptomatic or only mildly symptomatic for COVID-19. Patients underwent standard transthoracic echocardiogram (TTE) within 2-3 month from diagnosis and after negative NPS for SARS-CoV-2. We performed offline analysis with GE EchoPAC software to measure global longitudinal strain (GLS) of the LV using 2D speckle tracking imaging. Therefore, we compared the results with a matched group of 23 controls (13males, 56%). Results Cases and controls were similar regarding age (5.9 ± 4.1years vs. 6.4 ± 4.4 years, p = 0.63), body surface area (0.98 ± 0.3m2 vs. 0.8 ± 0.4m2, p = 0.17), LV FS (37.9 ± 5.9% vs. 36.4 ± 8.3%, p = 0.74) and LV biplane EF (63.9 ± 5.2% vs. 66.4 ± 5.3%, p = 0.11). GLS analysis showed significant strain reduction of the LV mid-wall segments and of the basal anterior, posterior and septal inferior segments among cases compared to controls. Furthermore, in the case group there were 7 subjects (30%) with a strain below 16.5% in at least 3 segments. Conclusion SARS-CoV-2 infection may affect LV deformation in asymptomatic or only mildly symptomatic children, showing a peculiar pattern with lower longitudinal strain in all mid-wall segments of LV compared to control subjects. The clinical significance of this findings is unclear and follow-up is needed to verify the reversibility of this alterations.

Published
2021

18. HIT Poster session 1P154Preclinical diastolic dysfunction is related to impaired endothelial function in patients with chronic kidney diseaseP155Early detection of left atrial and left ventricular abnormalities in hypertensive and obese womenP156Right ventricle preserved systolic function irrespective of right ventricular hypertrophy and disease severity in anderson fabry diseaseP157Left atrial volume and function in patients undergoing percutaneous mitral valve repairP158Impact of left ventricular dysfunction on outcomes of patients undergoing direct TAVI with a self-expanding bioprosthesisP159Anatomic Doppler spectrum – retrospective spectral tissue Doppler from ultra high frame rate tissue Doppler imaging for evaluation of tissue deformationP160Phasic dynamics of ischaemic mitral regurgitation after primary coronary intervention in acute myocardial infarction: serial echocardiographic assessment from emergency room to long-term follow-upP161Reproducibility of 3DE RV volumes - novel insights at a regional levelP162Pulmonary vascular capacitance as assessed by echocardiography in pulmonary arterial hypertensionP163Three-dimensional endocardial area strain: a novel parameter for quantitative assessment of global left ventricular systolic functionP164Role of exercise hemodynamics assessed by echocardiography on symptom reduction after MitraClipP165Early identification of ventricular dysfunction in patients with juvenile systemic sclerosisP166Heart failure with and without preserved ejection fraction - the role of biomarkers in the aspect of global longitudinal strainP167Complex systolic deformation of aortic root: insights from two dimensional speckle tracking imageP168Volumetric and deformational imaging usind 2d strain and 3d echocardiography in patients with pulmonary hypertensionP169Influence of pressure load and right ventricular morphology and function on tricuspid regurgitation in pulmonary arterial hypertensionP170Left ventricular myocardial diastolic deformation analysis by 2D speckle tracking echocardiography and relationship with conventional diastolic parameters in chronic aortic regurgitationP171Extracellular volume, and not native T1 time, distinguishes diffuse fibrosis in dilated or hypertrophic cardiomyopathy at 3TP172Left atrial strain is significantly reduced in arterial hypertensionP173Symptomatic severe secondary mitral regurgitation: LV enddiastolic diameter (LVEDD) as preferable parameter for risk stratificationP174Left ventricular mechanics in isolated left bundle branch block at rest and when exercising: exploration of the concept of conductive cardiomyopathyP175Assessment of myocardial scar by 2D contrast echocardiographyP176Chronic pericarditis - expression of a rare disease: Erdheim Chester diseaseP177Aortic arch mechanics with two-dimensional speckle tracking echocardiography to estimate the left ventricular remodelling in hypertensive patientsP178Strain analysis by tissue doppler imaging: comparison of conventional manual measurement with a semi-automated approachP179Distribution of extravascular lung water in heart failure patients assessed by lung ultrasoudP180Surrogate markers for obstructive coronary artery diseaseP181LA deformation and LV longitudinal strain by two-dimensional speckle tracking echocardiography as predictors of postoperative AF development after aortic valve replacement in ASP182Left ventricular diastolic dysfunction in type 2 diabetic patients with non alcoholic fatty liver diseaseP183Myocardial strain by speckle-tracking and evaluation of 3D ejection fraction in drug-induced cardiotoxicity's approach in breast cancer

Author

Gevaert, AB, primary, Borizanova, A, primary, Graziani, F, primary, Galuszka, O M, primary, Stathogiannis, K, primary, Lervik Nilsen, L C, primary, Nishino, S, primary, Willis, J, primary, Venner, C, primary, Luo, XX, primary, Van De Heyning, C M, primary, Castaldi, B, primary, Michalski, BW, primary, Wang, TL, primary, Aktemur, T, primary, Dorlet, S, primary, Verseckaite, R, primary, Amzulescu, MS, primary, Brecht, A, primary, Brand, M, primary, Galli, E, primary, Murzilli, R, primary, Bica, R, primary, Teixeira, R, primary, Schmid, J, primary, Miglioranza, MH, primary, Cherneva, ZH, primary, Gheghici, S, primary, Pernigo, M, primary, Rafael, D, primary, Van Craenenbroeck, AH, additional, Shivalkar, B, additional, Lemmens, K, additional, Vrints, CJ, additional, Van Craenenbroeck, EM, additional, Somleva, D, additional, Zlatareva- Gronkova, N, additional, Kinova, E, additional, Goudev, A, additional, Camporeale, A, additional, Pieroni, M, additional, Pedicino, D, additional, Laurito, MP, additional, Verrecchia, E, additional, Lanza, GA, additional, Manna, R, additional, Crea, F, additional, Reinthaler, M, additional, Rutschow, S, additional, Gross, M, additional, Landmesser, U, additional, Kasner, M, additional, Toutouzas, K, additional, Drakopoulou, M, additional, Latsios, G, additional, Synetos, A, additional, Kaitozis, O, additional, Trantalis, G, additional, Mastrokostopoulos, A, additional, Kotronias, R, additional, Tousoulis, D, additional, Brekke, BB, additional, Aase, SA, additional, Lonnebakken, MT, additional, Stensvag, D, additional, Amundsen, B, additional, Torp, H, additional, Stoylen, A, additional, Watanabe, N, additional, Kimura, T, additional, Nakama, T, additional, Furugen, M, additional, Koiwaya, H, additional, Ashikaga, K, additional, Kuriyama, N, additional, Shibata, Y, additional, Augustine, DX, additional, Knight, D, additional, Sparey, J, additional, Coghlan, G, additional, Easaw, J, additional, Huttin, O, additional, Voilliot, D, additional, Mercy, M, additional, Villemin, T, additional, Olivier, A, additional, Mandry, D, additional, Chaouat, A, additional, Juilliere, Y, additional, Selton-Suty, C, additional, Fang, F, additional, Li, S, additional, Zhang, ZH, additional, Yu, CM, additional, Bertrand, PB, additional, De Maeyer, C, additional, De Bock, D, additional, Paelinck, BP, additional, Claeys, MJ, additional, Reffo, E, additional, Balzarin, M, additional, Zulian, F, additional, Milanesi, O, additional, Miskowiec, D, additional, Kupczynska, K, additional, Peczek, L, additional, Nawrot, B, additional, Lipiec, P, additional, Kasprzak, JD, additional, Li, H, additional, Jin, XY, additional, Poci, N, additional, Kaymaz, C, additional, Venner, C, additional, Manenti, V, additional, Carillo, S, additional, Chabot, F, additional, Mizariene, V, additional, Rimkeviciute, D, additional, Bieseviciene, M, additional, Jonkaitiene, R, additional, Jurkevicius, R, additional, Roy, C, additional, Slimani, A, additional, Boileau, L, additional, De Meester, C, additional, Vancraeynest, D, additional, Pasquet, A, additional, Vanoverschelde, JL, additional, Pouleur, AC, additional, Gerber, BL, additional, Oertelt-Prigione, S, additional, Seeland, U, additional, Ruecke, M, additional, Regitz-Zagrosek, V, additional, Stangl, V, additional, Knebel, F, additional, Laux, D, additional, Roeing, J, additional, Butz, T, additional, Christ, M, additional, Grett, M, additional, Wennemann, R, additional, Trappe, H- J, additional, Fournet, M, additional, Leclercq, C, additional, Samset, E, additional, Daubert, J-C, additional, Donal, E, additional, Leo, LA, additional, Pasotti, E, additional, Klersy, C, additional, Moccetti, T, additional, Faletra, FF, additional, Dobre, D, additional, Darmon, S, additional, Dumitrescu, S, additional, Calistru, P, additional, Monteiro, R, additional, Ribeiro, M, additional, Garcia, J, additional, Cardim, N, additional, Goncalves, L, additional, Kaufmann, R, additional, Grubler, MR, additional, Verheyen, N, additional, Weidemann, F, additional, Binder, JS, additional, Santanna, RT, additional, Rover, MM, additional, Leiria, T, additional, Kalil, R, additional, Picano, E, additional, Gargani, L, additional, Kuneva, ZK, additional, Vasilev, DV, additional, Ianula, R, additional, Dasoveanu, M, additional, Calin, C, additional, Homentcovsci, C, additional, Siliste, R, additional, Bergamini, C, additional, Mantovani, A, additional, Bonapace, S, additional, Lipari, P, additional, Barbieri, E, additional, Bonora, E, additional, Targher, G, additional, Camarozano, AC, additional, Pereira Da Cunha, CL, additional, Padilha, SL, additional, Souza, AM, additional, and Freitas, AKE, additional

Published
2015
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20. Club 35 Moderated Poster session: Wednesday 3 December 2014, 09:00-16:00 * Location: Moderated Poster area

Author

Mihaila, S., primary, Aruta, P., additional, Muraru, D., additional, Miglioranza, M., additional, Cavalli, G., additional, Piasentini, E., additional, Iliceto, S., additional, Vinereanu, D., additional, Badano, L., additional, Ren, B., additional, Mulder, H., additional, Haak, A., additional, Mcghie, J., additional, Szili-Torok, T., additional, Nieman, K., additional, Van Stralen, M., additional, Pluim, J., additional, Geleijnse, M., additional, Bosch, J., additional, Lervik Nilsen, L. C., additional, Brekke, B., additional, Missant, C., additional, Haemers, P., additional, Tong, L., additional, Ortega, A., additional, Sutherland, G., additional, D'hooge, J., additional, Stoylen, A., additional, Assabiny, A., additional, Kovacs, A., additional, Faludi, M., additional, Tapolyai, M., additional, Berta, K., additional, Apor, A., additional, Merkely, B., additional, Kirschbaum, S., additional, Vletter, W., additional, Houtgraaf, J., additional, Teixeira, R., additional, Monteiro, R., additional, Garcia, J., additional, Silva, A., additional, Graca, M., additional, Baptista, R., additional, Ribeiro, M., additional, Cardim, N., additional, Goncalves, L., additional, Mihaila, S., additional, Cucchini, U., additional, Cecchetto, A., additional, Romeo, G., additional, Hamed, W., additional, Badran, H., additional, Noamany, M., additional, Ahmed, N., additional, Elsedi, M., additional, Yacoub, M., additional, Castaldi, B., additional, Vida, V., additional, Daniels, Q., additional, Reffo, E., additional, Crepaz, R., additional, Maschietto, N., additional, Campagnano, E., additional, Padalino, M., additional, Stellin, G., additional, Milanesi, O., additional, Galli, E., additional, Guirette, Y., additional, Auffret, V., additional, and Mabo, P., additional

Published
2014
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22. Club 35 Poster Session Wednesday 11 December: 11/12/2013, 09:30-16:00 * Location: Poster area

Author

Montoro Lopez, M., primary, Pons De Antonio, I., additional, Itziar Soto, C., additional, Florez Gomez, R., additional, Alonso Ladreda, A., additional, Rios Blanco, J., additional, Refoyo Salicio, E., additional, Moreno Yanguela, M., additional, Lopez Sendon, J., additional, Guzman Martinez, G., additional, Van De Heyning, C. M., additional, Magne, J., additional, Pierard, L., additional, Bruyere, P., additional, Davin, L., additional, De Maeyer, C., additional, Paelinck, B., additional, Vrints, C., additional, Lancellotti, P., additional, Michalski, B., additional, Krzeminska-Pakula, M., additional, Lipiec, P., additional, Szymczyk, E., additional, Chrzanowski, L., additional, Kasprzak, J., additional, Leao, R. N., additional, Florencio, A. F., additional, Oliveira, A. R., additional, Bento, B., additional, Lopes, S., additional, Calaca, J., additional, Palma Reis, R., additional, Krestjyaninov, M., additional, Gimaev, R., additional, Razin, V., additional, Arangalage, D., additional, Chiampan, A., additional, Cimadevilla, C., additional, Touati, A., additional, Himbert, D., additional, Brochet, E., additional, Iung, B., additional, Nataf, P., additional, Vahanian, A., additional, Messika-Zeitoun, D., additional, Guvenc, T., additional, Karacimen, D., additional, Erer, H., additional, Ilhan, E., additional, Sayar, N., additional, Karakus, G., additional, Eren, M., additional, Iriart, X., additional, Tafer, N., additional, Roubertie, F., additional, Mauriat, P., additional, Thambo, J., additional, Wang, J., additional, Fang, F., additional, Yip, G. W., additional, Sanderson, J., additional, Feng, W., additional, Yu, C., additional, Lam, Y., additional, Assabiny, A., additional, Apor, A., additional, Nagy, A., additional, Vago, H., additional, Toth, A., additional, Merkely, B., additional, Kovacs, A., additional, Castaldi, B., additional, Vida, V., additional, Guariento, A., additional, Padalino, M., additional, Cerutti, A., additional, Maschietto, N., additional, Biffanti, R., additional, Reffo, E., additional, Stellin, G., additional, Milanesi, O., additional, Baronaite-Dudoniene, K., additional, Urbaite, L., additional, Smalinskas, V., additional, Veisaite, R., additional, Vasylius, T., additional, Vaskelyte, J., additional, Puodziukynas, A., additional, Wieczorek, J., additional, Rybicka-Musialik, A., additional, Berger-Kucza, A., additional, Hoffmann, A., additional, Wnuk-Wojnar, A., additional, Mizia-Stec, K., additional, Melao, F., additional, Ribeiro, V., additional, Amorim, S., additional, Araujo, C., additional, Torres, J., additional, Cardoso, J., additional, Pinho, P., additional, Maciel, M., additional, Storsten, P., additional, Eriksen, M., additional, Boe, E., additional, Estensen, M., additional, Erikssen, G., additional, Smiseth, O., additional, Skulstad, H., additional, Miglioranza, M., additional, Gargani, L., additional, Sant`Anna, R., additional, Rover, M., additional, Martins, V., additional, Mantovanni, A., additional, Kalil, R., additional, Leiria, T., additional, Luo, X., additional, Lee, P., additional, Zhang, Z., additional, Kwong, J. S., additional, Borowiec, A., additional, Dabrowski, R., additional, Wozniak, J., additional, Jasek, S., additional, Chwyczko, T., additional, Kowalik, I., additional, Janas, J., additional, Musiej-Nowakowska, E., additional, Szwed, H., additional, Palinsky, M., additional, Petrovicova, J., additional, Pirscova, M., additional, Baricevic, Z., additional, Lovric, D., additional, Cikes, M., additional, Skoric, B., additional, Ljubas Macek, J., additional, Reskovic Luksic, V., additional, Separovic Hanzevacki, J., additional, Milicic, D., additional, Elmissiri, A., additional, El Shahid, G., additional, Abdal-Wahhab, S., additional, Vural, M. G., additional, Yilmaz, M., additional, Cetin, S., additional, Akdemir, R., additional, Yoldas, T. K., additional, Yeter, E., additional, Karamanou, A., additional, Hamodraka, E., additional, Lekakis, I., additional, Paraskevaidis, I., additional, Kremastinos, D., additional, Appiah-Dwomoh, E. K., additional, Wang, V., additional, Otto, C., additional, Mayar, F., additional, Bonaventura, K., additional, Sunman, H., additional, Canpolat, U., additional, Kuyumcu, M., additional, Yorgun, H., additional, Sahiner, L., additional, and Ozer, N., additional

Published
2013
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23. Poster session V * Saturday 11 December 2010, 08:30-12:30

Author

Pham, Q. H., primary, Von Lueder, T. G., additional, Namtvedt, S. K., additional, Rosjo, H., additional, Omland, T., additional, Steine, K., additional, Timoteo, A. T., additional, Mota Carmo, M., additional, Simoes, M., additional, Branco, L. M., additional, Ferreira, R. C., additional, Kato, R., additional, Ito, J., additional, Tahara, T., additional, Yokoyama, Y., additional, Ashikaga, T., additional, Satoh, Y., additional, Na, J. O., additional, Hong, H. E., additional, Kim, M. N., additional, Shin, S. Y., additional, Choi, C. U., additional, Kim, E. J., additional, Rha, S. W., additional, Park, C. G., additional, Seo, H. S., additional, Oh, D. J., additional, Ticulescu, R., additional, Brigido, S., additional, Vriz, O., additional, Sparacino, L., additional, Popescu, B. A., additional, Ginghina, C., additional, Carerj, S., additional, Nicolosi, G. L., additional, Antonini-Canterin, F., additional, Onaindia Gandarias, J. J., additional, Romero, A., additional, Laraudogoitia, E., additional, Velasco, S., additional, Quintana, O., additional, Cacicedo, A., additional, Rodriguez, I., additional, Alarcon, J. A., additional, Gonzalez, J., additional, Lekuona, I., additional, Subinas, A., additional, Abdula, G., additional, Lund, L. H., additional, Winter, R., additional, Brodin, L., additional, Sahlen, A., additional, Masaki, M., additional, Cha, Y. M., additional, Yuasa, T., additional, Dong, K., additional, Dong, Y. X., additional, Mankad, S. V., additional, Oh, J. K., additional, Vallet, F., additional, Lequeux, B., additional, Diakov, C., additional, Sosner, P., additional, Christiaens, L., additional, Coisne, D., additional, Kihara, C., additional, Murata, K., additional, Wada, Y., additional, Uchida, K., additional, Ueyama, T., additional, Okuda, S., additional, Susa, T., additional, Matsuzaki, M., additional, Cho, E. J., additional, Choi, K. Y., additional, Kwon, B. J., additional, Kim, D. B., additional, Jang, S. W., additional, Cho, J. S., additional, Jung, H. O., additional, Jeon, H. K., additional, Youn, H. J., additional, Kim, J. H., additional, Cikes, M., additional, Bijnens, B., additional, Velagic, V., additional, Kopjar, T., additional, Milicic, D., additional, Biocina, B., additional, Gasparovic, H., additional, Almuntaser, I., additional, Brown, A., additional, Foley, B., additional, Mulvihill, N., additional, Crean, P., additional, King, G., additional, Murphy, R., additional, Takata, Y., additional, Taniguchi, M., additional, Nobusada, S., additional, Sugawara, M., additional, Toh, N., additional, Kusano, K., additional, Itoh, H., additional, Wellnhofer, E., additional, Kriatselis, C., additional, Nedios, S., additional, Gerds-Li, J. H., additional, Fleck, E., additional, Poulsen, M. K., additional, Henriksen, J. E., additional, Dahl, J., additional, Johansen, A., additional, Haghfelt, T., additional, Hoilund-Carlsen, P. F., additional, Beck-Nielsen, H., additional, Moller, J. E., additional, Dankowski, R., additional, Wierzchowiecki, M., additional, Michalski, M., additional, Nowicka, A., additional, Szymanowska, K., additional, Pajak, A., additional, Poprawski, K., additional, Szyszka, A., additional, Kasner, M., additional, Westermann, D., additional, Schultheiss, H. P., additional, Tschoepe, C., additional, Watanabe, T., additional, Iwai-Takano, M., additional, Kobayashi, A., additional, Machii, H., additional, Takeishi, Y., additional, Paelinck, B. P., additional, Van Herck, P. L., additional, Bosmans, J. M., additional, Vrints, C. J., additional, Lamb, H. J., additional, Doltra, A., additional, Vidal, B., additional, Silva, E., additional, Poyatos, S., additional, Mont, L., additional, Berruezo, A., additional, Castel, A., additional, Tolosana, J. M., additional, Brugada, J., additional, Sitges, M., additional, Dencker, M., additional, Bjorgell, O., additional, Hlebowicz, J., additional, Szelenyi, Z. S., additional, Szenasi, G., additional, Kiss, M., additional, Prohaszka, Z., additional, Patocs, A., additional, Karadi, I., additional, Vereckei, A., additional, Saha, S. K., additional, Anderson, P. L., additional, Govind, S., additional, Govindan, M., additional, Moggridge, J. C., additional, Kiotsekoglou, A., additional, Gopal, A. S., additional, Loegstrup, B. B., additional, Christophersen, T. B., additional, Hoefsten, D. E., additional, Moeller, J. E., additional, Boetker, H. E., additional, Egstrup, K., additional, Graefe, M., additional, Huang, F. Q., additional, Zhang, R. S., additional, Le, T. T., additional, Tan, R. S., additional, Sattarzadeh Badkoubeh, R., additional, Tavoosi, A., additional, Elahian, A. R., additional, Drapkina, O., additional, Ivashkin, V. I., additional, Fazakas, A., additional, Pepo, L., additional, Janosi, O., additional, Kopitovic, I., additional, Goncalves, A., additional, Marcos-Alberca, P., additional, Almeria, C., additional, Feltes, G., additional, Rodriguez, E., additional, Garcia, E., additional, Hernandez-Antolin, R., additional, Macaya, C., additional, Silva Cardoso, J., additional, Zamorano, J. L., additional, Navarro, M. S., additional, Valentin, M., additional, Banes, C. M., additional, Rigo, F., additional, Grolla, E., additional, Tona, F., additional, Cuaia, V., additional, Moreo, A., additional, Badano, L., additional, Raviele, A., additional, Iliceto, S., additional, Tarzia, P., additional, Sestito, A., additional, Nerla, R., additional, Di Monaco, A., additional, Infusino, F., additional, Matera, D., additional, Greco, F., additional, Tacchino, R. M., additional, Lanza, G. A., additional, Crea, F., additional, Nemes, A., additional, Balazs, E., additional, Pinter, K. S., additional, Egyed, A., additional, Csanady, M., additional, Forster, T., additional, Holte, E., additional, Vegsundvag, J., additional, Hole, T., additional, Hegbom, K., additional, Wiseth, R., additional, Sharif, D., additional, Sharif-Rasslan, A., additional, Shahla, C., additional, Khalil, A., additional, Rosenschein, U., additional, Zagatina, A., additional, Zhuravskaya, N., additional, Tyurina, T. V., additional, Tagliamonte, E., additional, Cirillo, T., additional, Coppola, A., additional, Marinelli, U., additional, Romano, C., additional, Riccio, G., additional, Citro, R., additional, Astarita, C., additional, Capuano, N., additional, Quaranta, G., additional, Desiderio, A., additional, Frattini, S., additional, Faggiano, P., additional, Zilioli, V., additional, Locantore, E., additional, Longhi, S., additional, Bellandi, F., additional, Faden, G., additional, Triggiani, M., additional, Dei Cas, L., additional, Dalsgaard, M., additional, Kjaergaard, J., additional, Iversen, K., additional, Hassager, C., additional, Dinh, W., additional, Nickl, W. N., additional, Smettan, J. S., additional, Koehler, T. K., additional, Scheffold, T. D., additional, Coll Barroso, M. C. B., additional, Guelker, J. G., additional, Fueth, R. F., additional, Kamperidis, V., additional, Hadjimiltiades, S., additional, Sianos, G., additional, Efthimiadis, G., additional, Karvounis, H., additional, Parcharidis, G., additional, Styliadis, I. H., additional, Velasco Del Castillo, M. S., additional, Onaindia, J. J., additional, Telleria, M., additional, Carstensen, H. G., additional, Nordenberg, C., additional, Sogaard, P., additional, Fritz-Hansen, T., additional, Bech, J., additional, Galatius, S., additional, Jensen, J. S., additional, Mogelvang, R., additional, Bartko, P. E., additional, Graf, S., additional, Rosenhek, R., additional, Burwash, I. G., additional, Bergler-Klein, J., additional, Clavel, M.-A., additional, Baumgartner, H., additional, Pibarot, P., additional, Mundigler, G., additional, Kirilmaz, B., additional, Eser, I., additional, Tuzun, N., additional, Komur, B., additional, Dogan, H., additional, Taskiran Comez, A., additional, Ercan, E., additional, Cusma-Piccione, M., additional, Zito, C., additional, Oreto, G., additional, Piluso, S., additional, Tripepi, S., additional, Oreto, L., additional, Longordo, C., additional, Ciraci, L., additional, Di Bella, G., additional, Piatkowski, R., additional, Kochanowski, J., additional, Scislo, P., additional, Grabowski, M., additional, Marchel, M., additional, Roik, M., additional, Kosior, D., additional, Opolski, G., additional, Sknouril, L., additional, Dorda, M., additional, Holek, B., additional, Gajdusek, L., additional, Chovancik, J., additional, Branny, M., additional, Fiala, M., additional, Szymanski, P., additional, Lipczynska, M., additional, Klisiewicz, A., additional, Hoffman, P., additional, Jander, N., additional, Minners, J., additional, Martin, G., additional, Zeh, W., additional, Allgeier, M., additional, Gohlke-Baewolf, C., additional, Gohlke, H., additional, Nistri, S., additional, Porciani, M. C., additional, Attanasio, M., additional, Abbate, R., additional, Gensini, G. F., additional, Pepe, G., additional, Duncan, R. F., additional, Piantadosi, C., additional, Nelson, A. J., additional, Wittert, G., additional, Dundon, B., additional, Worthley, M. I., additional, Worthley, S. G., additional, Jung, P., additional, Berlinger, K., additional, Rieber, J., additional, Sohn, H. Z., additional, Schneider, P., additional, Leibig, M., additional, Koenig, A., additional, Klauss, V., additional, Tomkiewicz-Pajak, L., additional, Kolcz, J., additional, Olszowska, M., additional, Pieculewicz, M., additional, Podolec, P., additional, Przewlocki, T., additional, Suchon, E., additional, Sobien, B., additional, Wilkolek, P., additional, Ziembicka, A., additional, Hlawaty, M., additional, Van De Bruaene, A., additional, Hermans, H., additional, Buys, R., additional, Vanhees, L., additional, Delcroix, M., additional, Voigt, J.-U., additional, Budts, W., additional, De Cillis, E., additional, Acquaviva, T., additional, Basile, D., additional, Bortone, A. S., additional, Kalimanovska-Ostric, D., additional, Nastasovic, T., additional, Vujisic-Tesic, B., additional, Jovanovic, I., additional, Milakovic, B., additional, Dostanic, M., additional, Stosic, M., additional, Frogoudaki, A., additional, Andreou, K., additional, Parisis, J., additional, Triantafyllidi, E., additional, Gaitani, S., additional, Paraskevaidis, J., additional, Anastasiou-Nana, M., additional, De Pasquale, G., additional, Kuehn, A., additional, Petzuch, K., additional, Mueller, J., additional, Meierhofer, C., additional, Fratz, S., additional, Hager, A., additional, Hess, J., additional, Vogt, M., additional, Attenhofer Jost, C. H., additional, Dearani, J. A., additional, Scott, C. G., additional, Burkhart, H. M., additional, Connolly, H. M., additional, Vitarelli, A., additional, Battaglia, D., additional, Caranci, F., additional, Padella, V., additional, Continanza, G., additional, Dettori, O., additional, Capotosto, L., additional, Vitarelli, M., additional, De Cicco, V., additional, Cortez Morichetti, M., additional, Mohanan Nair, K. K., additional, Sasidaharan, B., additional, Thajudeen, A., additional, Tharakan, J. M., additional, Mertens, L., additional, Ahmad, N., additional, Kantor, P. K., additional, Grosse-Wortmann, L., additional, Friedberg, M. K., additional, Bernard, Y. F., additional, Morel, M. A., additional, Descotes-Genon, V., additional, Jehl, J., additional, Meneveau, N., additional, Schiele, F., additional, Kaldararova, M., additional, Simkova, I., additional, Tittel, P., additional, Masura, J., additional, Trojnarska, O., additional, Szczepaniak, L., additional, Mizia -Stec, K., additional, Cieplucha, A., additional, Bartczak, A., additional, Grajek, S., additional, Tykarski, A., additional, Gasior, Z., additional, Babovicvuksanovic, D., additional, Bonnichsen, C. R., additional, Morgan, G. J., additional, Slorach, C., additional, Hui, W., additional, Sarkola, T., additional, Lee, K. J., additional, Chaturvedi, R., additional, Benson, L., additional, Bradley, T., additional, Iancu, M. E., additional, Ghiorghiu, I., additional, Serban, M., additional, Craciunescu, I., additional, Hodo, A., additional, Morgan, J., additional, Roche, L., additional, Lee, K., additional, Milanesi, O., additional, Favero, V., additional, Padalino, M., additional, Biffanti, R., additional, Cerutti, A., additional, Maschietto, N., additional, Reffo, E., additional, Vida, V., additional, Stellin, G., additional, Irtyuga, O., additional, Gamazin, D., additional, Voronkina, I., additional, Tsoyi, N., additional, Gudkova, E., additional, Moiseeva, O., additional, Aggeli, C., additional, Kazazaki, C., additional, Felekos, I., additional, Lagoudakou, S., additional, Roussakis, G., additional, Skoumas, J., additional, Pitsavos, C., additional, Stefanadis, C., additional, Cueff, C., additional, Keenan, N., additional, Steg, P. G., additional, Cimadevilla, C., additional, Ducrocq, G., additional, Vahanian, A., additional, Messika-Zeitoun, D., additional, Petrella, L., additional, Mazzola, A. M., additional, Villani, C. V., additional, Giancola, R. G., additional, Ciocca, M. C., additional, Di Eusanio, D. E. M., additional, Nolan, S., additional, Ionescu, A., additional, Skaug, T. R., additional, Amundsen, B. H., additional, Hergum, T., additional, Torp, H., additional, Haugen, B. O., additional, Lopez Aguilera, J., additional, Mesa Rubio, D., additional, Ruiz Ortiz, M., additional, Delgado Ortega, M., additional, Villanueva Fernandez, E., additional, Cejudo Diaz Del Campo, L., additional, Toledano Delgado, F., additional, Leon Del Pino, M., additional, Romo Pena, E., additional, Suarez De Lezo Cruz-Conde, J., additional, De Marco, E., additional, Colucci, A., additional, Comerci, G., additional, Gabrielli, F. A., additional, Natali, R., additional, Garramone, B., additional, Savino, M., additional, Lotrionte, M., additional, Sonaglioni, A., additional, Loperfido, F., additional, Zdravkovic, M., additional, Perunicic, J., additional, Krotin, M., additional, Ristic, M., additional, Vukomanovic, V., additional, Zaja, M., additional, Radovanovic, S., additional, Saric, J., additional, Zdravkovic, D., additional, Cotrim, C., additional, Almeida, A. R., additional, Miranda, R., additional, Almeida, A. G., additional, Picano, E., additional, Carrageta, M., additional, D'andrea, A., additional, Cocchia, R., additional, Riegler, L., additional, Golia, E., additional, Scarafile, R., additional, Caso, P., additional, Russo, M. G., additional, Bossone, E., additional, Calabro', R., additional, Noman, H., additional, Adel, A., additional, Elfaramawy, A. M. R., additional, Abdelraouf, M., additional, Elnaggar, W. A. E. L., additional, Baligh, E., additional, Sargento, L., additional, Silva, D., additional, Goncalves, S., additional, Ribeiro, S., additional, Vinhas Sousa, G., additional, Almeida, A., additional, Lopes, M., additional, Rodriguez-Manero, M., additional, Aguado Gil, L., additional, Azcarate, P., additional, Lloret Luna, P., additional, Macias Gallego, A., additional, Castano, S. A. R. A., additional, Garcia, M., additional, Pujol Salvador, C., additional, Barba, J., additional, Redondo, P., additional, Tomasoni, L., additional, Sitia, S., additional, Atzeni, F., additional, Gianturco, L., additional, Ricci, C., additional, Sarzi-Puttini, P., additional, Turiel, M., additional, De Gennaro Colonna, V., additional, Uejima, T., additional, Jaroch, J., additional, Polombo, C., additional, Hughes, A., additional, Vinereanu, D., additional, Evanvelista, A., additional, Leftheriotis, G., additional, Fraser, A. G., additional, Lewczuk, A., additional, Sobkowicz, B., additional, Tomaszuk-Kazberuk, A., additional, Sawicki, R., additional, Hirnle, T., additional, Michalski, B. W., additional, Filipiak, D., additional, Kasprzak, J. D., additional, Lipiec, P., additional, Dalen, H., additional, Mjolstad, O. C., additional, Klykken, B. E., additional, Graven, T., additional, Martensson, M., additional, Olsson, M., additional, Brodin, L.-A., additional, Enache, R., additional, Leiballi, E., additional, Penhall, A., additional, Perry, R., additional, Altman, M., additional, Sinhal, A., additional, Bennetts, J., additional, Chew, D. P., additional, Joseph, M. X., additional, Larsen, L. H., additional, Kristensen, T., additional, Kober, L. V., additional, Kofoed, K. F., additional, Moscoso Costa, F., additional, Ribeiras, R., additional, Brito, J., additional, Boshoff, S., additional, Neves, J., additional, Teles, R., additional, Canada, M., additional, Andrade, M. J., additional, Gouveia, R., additional, Silva, A., additional, Miskovic, A., additional, Poerner, T. P., additional, Stiller, C. S., additional, Goebel, B. G., additional, Moritz, A. M., additional, Stefani, L., additional, Galanti, G. G., additional, Moraldo, M., additional, Bergamini, C., additional, Pabari, P. A., additional, Dhutia, N. M., additional, Malaweera, A. S. N., additional, Willson, K., additional, Davies, J., additional, Hughes, A. D., additional, Xu, X. Y., additional, Francis, D. P., additional, Jasaityte, R., additional, Amundsen, B., additional, Barbosa, D., additional, Loeckx, D., additional, Kiss, G., additional, Orderud, F., additional, Robesyn, V., additional, Claus, P., additional, D'hooge, J., additional, Nao, T., additional, Miura, T., additional, Shams, K., additional, Samir, S., additional, Samir, R., additional, El-Sayed, M., additional, Anwar, A. M., additional, Nosir, Y., additional, Galal, A., additional, Chamsi-Pasha, H., additional, Ciobanu, A., additional, Dulgheru, R., additional, Bennett, S., additional, De Luca, A., additional, Toncelli, L., additional, Cappelli, F., additional, Cappelli, B., additional, Vono, M. C. R., additional, Galanti, G., additional, Zorman, Y., additional, Yilmazer, M. S., additional, Akyildiz, M., additional, Gurol, T., additional, Aydin, A., additional, Dagdeviren, B., additional, and Kalangos, A., additional

Published
2010
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26. Unexpected finding in a Neonate's left atrial appendage

Author

Avesani Martina, Cerutti Alessia, Reffo Elena, Biffanti Roberta, Castaldi Biagio, Sirico Domenico, Padalino Massimo, Vida Vladimiro, and Di Salvo Giovanni

Subjects
Inverted left atrial appendage-left atrial thrombus, Diseases of the circulatory (Cardiovascular) system, RC666-701
Published
2021
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31. HIT Poster session 1

Author

Gevaert, AB, Van Craenenbroeck, AH, Shivalkar, B, Lemmens, K, Vrints, CJ, Van Craenenbroeck, EM, Borizanova, A, Somleva, D, Zlatareva- Gronkova, N, Kinova, E, Goudev, A, Graziani, F, Camporeale, A, Pieroni, M, Pedicino, D, Laurito, MP, Verrecchia, E, Lanza, GA, Manna, R, Crea, F, Galuszka, O M, Reinthaler, M, Rutschow, S, Gross, M, Landmesser, U, Kasner, M, Stathogiannis, K, Toutouzas, K, Drakopoulou, M, Latsios, G, Synetos, A, Kaitozis, O, Trantalis, G, Mastrokostopoulos, A, Kotronias, R, Tousoulis, D, Lervik Nilsen, L C, Brekke, BB, Aase, SA, Lonnebakken, MT, Stensvag, D, Amundsen, B, Torp, H, Stoylen, A, Nishino, S, Watanabe, N, Kimura, T, Nakama, T, Furugen, M, Koiwaya, H, Ashikaga, K, Kuriyama, N, Shibata, Y, Willis, J, Augustine, DX, Knight, D, Sparey, J, Coghlan, G, Easaw, J, Venner, C, Huttin, O, Voilliot, D, Mercy, M, Villemin, T, Olivier, A, Mandry, D, Chaouat, A, Juilliere, Y, Selton-Suty, C, Luo, XX, Fang, F, Li, S, Zhang, ZH, Yu, CM, Van De Heyning, C M, Bertrand, PB, De Maeyer, C, De Bock, D, Paelinck, BP, Vrints, CJ, Claeys, MJ, Castaldi, B, Reffo, E, Balzarin, M, Zulian, F, Milanesi, O, Michalski, BW, Miskowiec, D, Kupczynska, K, Peczek, L, Nawrot, B, Lipiec, P, Kasprzak, JD, Wang, TL, Li, H, Jin, XY, Aktemur, T, Poci, N, Kaymaz, C, Dorlet, S, Huttin, O, Voilliot, D, Venner, C, Villemin, T, Manenti, V, Carillo, S, Chabot, F, Juilliere, Y, Selton-Suty, C, Verseckaite, R, Mizariene, V, Rimkeviciute, D, Bieseviciene, M, Jonkaitiene, R, Jurkevicius, R, Amzulescu, MS, Roy, C, Slimani, A, Boileau, L, De Meester, C, Vancraeynest, D, Pasquet, A, Vanoverschelde, JL, Pouleur, AC, Gerber, BL, Brecht, A, Oertelt-Prigione, S, Seeland, U, Ruecke, M, Regitz-Zagrosek, V, Stangl, V, Knebel, F, Brand, M, Laux, D, Roeing, J, Butz, T, Christ, M, Grett, M, Wennemann, R, Trappe, H- J, Galli, E, Fournet, M, Leclercq, C, Samset, E, Daubert, J-C, Donal, E, Murzilli, R, Leo, LA, Pasotti, E, Klersy, C, Moccetti, T, Faletra, FF, Bica, R, Dobre, D, Darmon, S, Dumitrescu, S, Calistru, P, Teixeira, R, Monteiro, R, Ribeiro, M, Garcia, J, Cardim, N, Goncalves, L, Schmid, J, Kaufmann, R, Grubler, MR, Verheyen, N, Weidemann, F, Binder, JS, Miglioranza, MH, Santanna, RT, Rover, MM, Leiria, T, Kalil, R, Picano, E, Gargani, L, Cherneva, ZH, Kuneva, ZK, Vasilev, DV, Gheghici, S, Ianula, R, Dasoveanu, M, Calin, C, Homentcovsci, C, Siliste, R, Pernigo, M, Bergamini, C, Mantovani, A, Bonapace, S, Lipari, P, Barbieri, E, Bonora, E, Targher, G, Rafael, D, Camarozano, AC, Pereira Da Cunha, CL, Padilha, SL, Souza, AM, and Freitas, AKE

Abstract

Background: Preclinical diastolic dysfunction is highly prevalent in the aging population, but mechanisms for progression into heart failure with preserved ejection fraction (HFpEF) are still obscure. Recently, microvascular endothelial inflammation and endothelial dysfunction (ED) were advocated as primum movens in the development of HFpEF. Purpose: We aimed to evaluate whether ED and arterial stiffness relate to diastolic and other structural and functional cardiac parameters. This was studied in patients with chronic kidney disease (CKD), known to be prone to diastolic dysfunction and left ventricular hypertrophy. Methods: Consecutive CKD patients, without concomitant cardiovascular disease, were included. Diastolic parameters were assessed by cardiac ultrasound using E/e´ ratio and left atrial volume index (LAVi). Also, left ventricular mass index (LVMi) and interventricular septum thickness (IVSd) were included. Endothelial function was evaluated by flow-mediated dilation (FMD) of the brachial artery induced by hyperaemia. Arterial stiffness was assessed by measuring carotid-femoral pulsed wave velocity (PWV). Results: After exclusion of patients with normal diastolic function (n=11), 52 patients (age 53.9 ± 12.8 years, 53.2% male) were assessed, of whom 36 underwent a second analysis after 3 months (total measurements 88). Mean creatinin clearance (eGFR) was 42.9 ± 23.2 ml/min/1.73m2. Comorbidities included arterial hypertension (90.4%) and diabetes mellitus (9.6%). Mean Framingham Heart score was 18.9% ± 18.7. Endothelial function was impaired (FMD 4.64% ± 2.61), and patients showed increased arterial stiffness (PWV 8.96 m/s ± 2.18). Ratio of E/e´ was elevated (>12) in 36.4% of measurements. LVMi was raised in 28.4%, and LAVi was elevated in 45.1%. Patients with E/e´>12 had impaired FMD (p=0.005) and elevated PWV (p=0.047). In bivariate correlation analysis, FMD correlated with E/e´ (r=-0.289, p=0.010) and with IVSd (r=-0.315, p=0.005). PWV did not show a relation with any of the diastolic indices (all p>0.05). In a multiple linear regression model, accounting for age, sex, smoking, eGFR, and PWV, FMD remained independently associated to E/e´ (ß=-0.279, p=0.011) and IVSd (ß=-0.232, p=0.026). Conclusions: In CKD patients with preclinical diastolic dysfunction, impaired endothelial function correlates with higher filling pressures and structural cardiac changes. This observation supports the paradigm that ED plays a role in the pathophysiology of diastolic dysfunction, even in an asymptomatic stage.

Published
2015
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32. HIT Poster session 3

Author

Stella, S, Rosa, I, Marini, C, Ancona, F, Spagnolo, P, Latib, A, Romano, V, Colombo, A, Margonato, A, Agricola, E, Li, H, Yuan, L, Xie, MX, Jin, XY, Stathogiannis, K, Toutouzas, K, Drakopoulou, M, Latsios, G, Synetos, A, Sanidas, E, Kaitozis, O, Trantalis, G, Gerckens, U, Tousoulis, D, Stojkovic, S, Tesic, M, Stojkovic, S, Stepanovic, J, Trifunovic, D, Beleslin, B, Giga, V, Nedeljkovic, I, Djordjevic Dikic, A, Ondrus, T, Bartunek, J, Vanderheyden, M, Stockman, B, Mirica, C, Kotrc, M, Van Praet, F, Van Camp, G, Penicka, M, Plaza Lopez, D, Igual Munoz, B, Sanchez Lacuesta, ME, Lopez Vilella, R, Domenech Tort, MD, Sepulveda Sanchis, P, Ten Morro, F, Calvillo Batlles, P, Montero Argudo, JA, Martinez Dolz, LV, Jinno, S, Yamada, A, Sugimoto, K, Ito, S, Kato, M, Inuzuka, H, Sugiyama, H, Takada, K, Ozaki, Y, Ishii, J, Verseckaite, R, Mizariene, V, Gaileviciute, K, Bieseviciene, M, Jonkaitiene, R, Jurkevicius, R, Oliveira Da Silva, C, Gunyeli, E, Winter, R, Back, M, Settergren, M, Manouras, A, Shahgaldi, K, Altin, C, Ozsoy, HM, Gezmis, E, Yilmaz, M, Tunc, E, Sade, LE, Muderrisoglu, H, Krestjyaninov, MV, Gimaev, RH, Melnikova, MA, Olezov, NV, Ruzov, VI, Izci, S, Dogan, C, Acar, R, Cetin, G, Bakal, RB, Unkun, T, Cap, M, Erdogan, E, Kaymaz, C, Ozdemir, N, Santos, M, Leite, L, Martins, R, Baptista, R, Barbosa, A, Ribeiro, N, Oliveira, A, Castro, G, Pego, M, Urbano-Moral, JA, Gutierrez-Garcia-Moreno, L, Rodriguez-Palomares, JF, Galuppo, V, Maldonado-Herrera, G, Teixido-Tura, G, Gruosso, D, Gonzalez-Alujas, T, Evangelista-Massip, A, Spartera, M, Stella, S, Rosa, I, Ancona, F, Marini, C, Latib, A, Giannini, F, Colombo, A, Margonato, A, Agricola, E, Gonzalvez-Garcia, A, Urbano-Moral, JA, Matabuena-Gomez-Limon, J, Grande-Trillo, A, Rojas-Bermudez, C, Rodriguez-Puras, MJ, Martinez-Martinez, A, Lopez-Pardo, F, Lopez-Haldon, JE, Miskowiec, D, Kupczynska, K, Kasprzak, JD, Lipiec, P, Hagrass, MUHAMMAD, Abdelrahman Sharaf El Dein, AHMED, Shawky El Serafy, AHMED, Rajan, RAJESH, Rady, M, Sveric, K, Kvakan, H, Strasser, RH, Reskovic Luksic, V, Cekovic, S, Veceric, S, Separovic Hanzevacki, J, Castaldi, B, Romanato, S, Callegari, A, Bernardinello, V, Reffo, E, Milanesi, O, Silva, T, Agapito, A, Sousa, L, Oliveira, JA, Branco, LM, Timoteo, AT, Galrinho, A, Thomas, B, Tavares, NJ, Cruz Ferreira, R, Silva, T, Agapito, A, Sousa, L, Oliveira, JA, Branco, LM, Timoteo, AT, Galrinho, A, Thomas, B, Tavares, NJ, Cruz Ferreira, R, Silva, T, Agapito, A, Sousa, L, Oliveira, JA, Soares, R, Aguiar Rosa, SA, Morais, L, Thomas, B, Tavares, NJ, Cruz Ferreira, R, Kolossvary, M, Szilveszter, B, Elzomor, H, Karolyi, M, Raaijmakers, R, Benke, K, Celeng, C, Bagyura, Z, Merkely, B, Maurovich-Horvat, P, Basuoni, A, Shaheen, S, Abdelkader, M, Rasheed, T, Miskowiec, D, Kasprzak, JD, Lipiec, P, Peovska Mitevska, I, Srbinovska, E, Pop Gorceva, D, Zdravkovska, M, Aguiar Rosa, S, Galrinho, A, Moura Branco, L, Timoteo, AT, Agapito, A, Sousa, L, Oliveira, JA, Rodrigues, I, Viveiros Monteiro, A, and Cruz Ferreira, R

Abstract

Purpose: the assessment of aortic annular size in TAVI patients, is critical and inappropriate sizing is a main reason of paravalvular aortic regurgitation (PVR). Data on aortic annulus measures assessed by 3D-Transesophageal Echocardiography (3D-TEE) compared to Multislice Computed Tomography (MSCT), are limited and discordant. The aim was to compare aortic annulus measurements obtained by 3D-TEE with MSCT, evaluating the impact on prosthesis size selection and their ability to predict PVR ≥ mild. Materials and Methods: 53 consecutive TAVI patients (mean age 81.5 ± 5.2 years, 22 women) underwent both 3D-TEE and MSCT. The 3D volume dataset was acquired containing the LVOT, aortic annulus/valve and aortic root. 3D-echocardiographic reconstruction for measurement of the aortic annulus was performed with a dedicated software (EchoPac). This allowed for precise identification of the annular plane from orthogonal views, to accurately perform mid-systole measurements. MSCT measurements were obtained in diastole. The final valve sizing was based on MSCT measurements. Then 3D-TEE data were submitted to one TAVI operator for blinded definition of prosthesis sizing, in order to test the agreement between the two modalities. Finally, Cover Index (CI) and absolute difference (Δ) between prosthesis size and 3D-TEE and MSCT annulus measures, were assessed for estimation of PVR ≥ mild predictivity. Results: although absolute differences were small, 3D-TEE measurements were statistically significantly smaller than MDCT ones: for major (coronal) diameter a mean difference=−2.3 mm (range, −2.1 to 6.7 mm, p= 0.0001), mean perimeter difference=−3.9 mm (range, −8.0 to 15,9 mm, p=0.006) and a mean area difference=−2.8 cm2 (range, −6.6 to 12.3 cm2, p=0.05), with the exception of minor (sagittal) diameter (mean difference= 0.02 ± 3 mm, p= 0.9), with a very good correlation for minor (sagittal) diameter and area (r= 0.76 and 0.79, respectively, p=0.0001). We found a 68% of concordance between 3D-TEE and MSCT for the implanted prosthesis size. Among the 32% of discordance, 3D-TEE lead to prosthesis underestimation in most of cases. Only MSCT perimeter measurement had statistically higher predictive value for the presence of ≥ mild PVR (AUC for Δ Perimeter and CI Perimeter=0.77 and 0.72, respectively). Conclusion: 3D-TEE annulus measurements of sagittal diameter and area evaluated in mid-systole well correlate to MDCT measurements in diastole. Moreover there is a moderate concordance between the two modalities, for final prosthesis sizing. Only MSCT perimeter measurement, predict post-TAVI PVR with good accuracy.

Published
2015
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33. Club 35 Moderated Poster session: Wednesday 3 December 2014, 09:00-16:00 * Location: Moderated Poster area

Author

Mihaila, S, Aruta, P, Muraru, D, Miglioranza, M, Cavalli, G, Piasentini, E, Iliceto, S, Vinereanu, D, Badano, LP, Ren, B, Mulder, HW, Haak, A, Mcghie, J, Szili-Torok, T, Nieman, K, Van Stralen, M, Pluim, JPW, Geleijnse, ML, Bosch, JG, Lervik Nilsen, L C, Brekke, B, Missant, C, Haemers, P, Tong, L, Ortega, A, Sutherland, G, D'hooge, J, Stoylen, A, Assabiny, A, Kovacs, A, Faludi, M, Tapolyai, M, Berta, K, Apor, A, Merkely, B, Ren, B, Kirschbaum, S, Vletter, W, Houtgraaf, J, Geleijnse, M, Teixeira, R, Monteiro, R, Garcia, J, Silva, A, Graca, M, Baptista, R, Ribeiro, M, Cardim, N, Goncalves, L, Miglioranza, MH, Mihaila, S, Muraru, D, Cucchini, U, Cavalli, G, Cecchetto, A, Romeo, G, Iliceto, S, Badano, LP, Hamed, W, Badran, HMB, Noamany, MFN, Ahmed, NFA, Elsedi, MSE, Yacoub, MY, Castaldi, B, Vida, V, Daniels, Q, Reffo, E, Crepaz, R, Maschietto, N, Campagnano, E, Padalino, M, Stellin, G, Milanesi, O, Galli, E, Guirette, Y, Auffret, V, and Mabo, P

Abstract

Background: Mitral annulus (MA) remodeling was suggested to have a role in the occurrence of mitral valve (MV) leaflet flail in pts with organic mitral regurgitation (OMR). Aim: To assess the extent of MA remodeling and dysfunction in relation to the severity of MV disease in pts with OMR. Methods: We acquired 3D full-volumes of the MA and left ventricle (LV) in 52 pts (57 ± 15 yrs, 34 men) with OMR (40 pts with posterior mitral prolapse, 12 pts with Barlow disease), and in sinus rhythm. MV morphology was assessed using both en-face view of volume rendered images and longitudinal slices of the datasets. MA size and function were automatically assessed during cardiac systole (MV assessment 2.3, TomTec). LV volumes and ejection fraction (LVEF) were measured with AutoLVQ (Echopac BT 12, GE). Results: 14 pts showed a flail of the MV, and 38 pts MV prolapse without flail. LVEF, MA displacement and MA size and geometry were similar in pts with and without MV flail (Table). Conversely, MA fractional area change was significantly decreased in pts with leaflet flail. Binary logistic regression showed that decreased MA fractional area change was associated with the presence of leaflet flail (β=0.20, p=0.02). Conclusions: In pts with OMR and normal LV function, the contractile dysfunction of the MA, and not the size of the MA, is associated with the presence of leaflet flail. Further studies are needed to assess if the MA contractile dysfunction precedes or is a consequence of the occurrence of MV flail. MA parametersMVP with flail N=14MVP without flail N=38pAntero-posterior diameter (cm)3.6 ± 0.63.4 ± 0.60.274Anterolateral-posteromedial diameter (cm)4.6 ± 0.74.6 ± 0.70.946MA area (cm2)13.8 ± 3.812.9 ± 4.10.458MA circumference (cm)13.5 ± 2.013.0 ± 2.00.464Anterior leaflet area (cm2)6.3 ± 2.26.5 ± 2.30.485Posterior leaflet area (cm2)9.1 ± 2.47.5 ± 2.90.063Sphericity Index0.8 ± 0.080.75 ± 0.070.051Non-planarity angle (0)150 ± 12155 ± 110.190MA height (mm)6.0 ± 0.25.4 ± 0.20.297MA fractional area change (%)19 ± 323 ± 60.015*MA displacement (mm)10.6 ± 2.69.5 ± 3.30.237

Published
2014
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34. Club 35 Poster session 3: Friday 5 December 2014, 08:30-18:00 * Location: Poster area

Author

Kovacs, A, Assabiny, A, Lakatos, B, Apor, A, Nagy, A, Kutyifa, V, Merkely, B, Ulbrich, S, Sveric, KM, Rady, M, Strasser, RH, Ebner, B, Bielecka-Dabrowa, A, Michalska, M, Gluba, A, Rysz, J, Banach, M, Lervik Nilsen, L C, Brekke, B, Missant, C, Ortega, A, Haemers, P, Tong, L, Sutherland, G, D'hooge, J, Stoylen, A, Gurzun, M M, Ionescu, A, Park, JJ, Park, S-J, Cho, EJ, Kim, JH, Lee, S-C, Park, SW, Santoro, A, Federico Alvino, FA, Carlo Gaetano Sassi, CGS, Giovanni Antonelli, GA, Sergio Mondillo, SM, Chumarnaya, T, Alueva, Y, Kochmasheva, VV, Mikhailov, SP, Ostern, OV, Solovyova, O, Revishvili, A, Markhasin, VS, Rodriguez Munoz, D, Carbonell Sanroman, A, Moya Mur, JL, Fernandez Santos, S, Lazaro Rivera, C, Valverde Gomez, M, Casas Rojo, E, Garcia Martin, A, Fernandez-Golfin, C, Zamorano Gomez, JL, Kanda, T, Fujita, M, Masuda, M, Iida, O, Okamoto, S, Ishihara, T, Nanto, K, Shiraki, T, Takahara, M, Uematsu, M, Kolesnyk, M Y, Victor, K, Lux, D, Carr-White, G, Barrett, N, Glover, G, Langrish, C, Meadows, C, Ioannou, N, Castaldi, B, Vida, V, Argiolas, A, Maschietto, N, Cerutti, A, Biffanti, R, Reffo, E, Padalino, M, Stellin, G, Milanesi, O, Guvenc, TS, Dogan, C, Yildirim, BZ, KUL, S, Karabag, Y, Cetin, R, Kaya, Y, Karadag, P, Degirmencioglu, A, Balci, B, Simova, I, Katova, T, Galderisi, M, Lalov, I, Onciul, S, Alexandrescu, A, Petre, I, Zamfir, D, Onut, R, Tautu, O, Dorobantu, M, Caldas, ALE, Ladeia, AMLT, D'almeida, JCMDA, Guimaraes, ACG, Caldas, Alessandra Carvalho, Ball, C, Abdelmoneim Mohamed, SS, Huang, R, Zysek, V, Mantovani, F, Scott, C, Mccully, R, Mulvagh, S, Lee, J-H, Cho, GY, Mihaila, S, Muraru, D, Aruta, P, Piasentini, E, Cavalli, G, Ucci, L, Peluso, D, Vinereanu, D, Iliceto, S, Badano, LP, Ozawa, K, Funabashi, N, Takaoka, H, Kamata, T, Nomura, F, Kobayashi, Y, Ovsianas, J, Valuckiene, Z, Mizariene, V, Jurkevicius, R, Reskovic Luksic, V, Dosen, D, Cekovic, S, Separovic Hanzevacki, J, Simova, I, Katova, T, Santoro, C, Galderisi, M, Kalcik, M, Cakal, B, Gursoy, MO, Astarcioglu, MA, Yesin, M, Gunduz, S, Karakoyun, S, Cersit, S, Toprak, C, and Ozkan, M

Abstract

Data on deformation profile of athlete's heart are still scarce. However, strain values of athletes can reveal several correspondence between training and systolic or diastolic function and can deepen our understanding of their cardiac physiology. We sought to investigate the left ventricular (LV) longitudinal and circumferential deformation parameters in a large cohort of athletes and to determine the related factors.  Elite athletes (EA; n=147, mean age 26±6 years, 20% women) competing in sport disciplines of combined exercise nature, were investigated and compared to age- and gender matched, healthy, sedentary volunteers (NC; n=44, 27±8 years, 25% women). Beyond standard two-dimensional echocardiographic protocol (Philips iE33), parasternal short-axis and apical views optimized for speckle tracking analysis were obtained. LV global longitudinal strain (GLS) and global circumferential strain (GCS) were calculated by averaging the values of the standard 16 LV segments. Data are presented as mean±SD, p values under 0.05 were considered as statistically significant.  EA had increased LV mass (EA vs. NC; 113±22 vs. 95±30 g/m2, p<0.01). Ejection fraction did not differ between groups (59.6±6.3 vs. 60.5±4.5 %). GLS of athletes was significantly lower (-21.5±2.3 vs. -22.9±2.9 %, p<0.01), while GCS was similar compared to controls (-29.7±4.8 vs. -29.9±4.9 %). Strain values did not differ between genders (EA group, females vs. males; GLS: -22.2±1.6 vs. -21.3±2.4; GCS -29.9±5.1 vs. -29.7±4.7 %). In contrast to NC, in the EA group GLS correlated with age (r=-0.29), weight (r=0.36), height (r=0.41) and also with early diastolic mitral inflow velocity (r=-0.28) and isovolumic relaxation time (r=0.31, p<0.05). In athletes, GCS inversely correlated with LV mass (r=0.38) and was found to be the only independent predictor of ejection fraction among strain parameters (β=-0.31, p<0.01).  LV longitudinal strain is decreased, circumferential strain is preserved in elite athletes, which might have a key role in maintaining ejection fraction at resting conditions. LV longitudinal strain is related to anthropometric features and early diastolic function, whereas circumferential strain is affected by LV mass. Our results can represent reference values for athlete's heart using the current platform.

Published
2014
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36. Club 35 Poster Session Wednesday 11 December: 11/12/2013, 09:30-16:00 * Location: Poster area

Author

Montoro Lopez, M, Pons De Antonio, I, Itziar Soto, C, Florez Gomez, R, Alonso Ladreda, A, Rios Blanco, JJ, Refoyo Salicio, E, Moreno Yanguela, M, Lopez Sendon, JL, Guzman Martinez, G, Van De Heyning, C M, Magne, J, Pierard, LA, Bruyere, PJ, Davin, L, De Maeyer, C, Paelinck, BP, Vrints, CJ, Lancellotti, P, Michalski, BW, Krzeminska-Pakula, M, Lipiec, P, Szymczyk, E, Chrzanowski, L, Kasprzak, JD, Leao, R N, Florencio, A F, Oliveira, A R, Bento, B, Lopes, S, Calaca, J, Palma Reis, R, Krestjyaninov, MV, Gimaev, RH, Razin, VA, Arangalage, D, Chiampan, A, Cimadevilla, C, Touati, A, Himbert, D, Brochet, E, Iung, B, Nataf, P, Vahanian, A, Messika-Zeitoun, D, Guvenc, TS, Karacimen, D, Erer, HB, Ilhan, E, Sayar, N, Karakus, G, Eren, M, Iriart, X, Tafer, N, Roubertie, F, Mauriat, P, Thambo, JB, Wang, J, Fang, F, Yip, G WK, Sanderson, J, Feng, W, Yu, CM, Lam, YY, Assabiny, A, Apor, A, Nagy, A, Vago, H, Toth, A, Merkely, B, Kovacs, A, Castaldi, B, Vida, VL, Guariento, A, Padalino, M, Cerutti, A, Maschietto, N, Biffanti, R, Reffo, E, Stellin, G, Milanesi, O, Baronaite-Dudoniene, K, Urbaite, L, Smalinskas, V, Veisaite, R, Vasylius, T, Vaskelyte, J, Puodziukynas, A, Wieczorek, J, Rybicka-Musialik, A, Berger-Kucza, A, Hoffmann, A, Wnuk-Wojnar, A, Mizia-Stec, K, Melao, F, Ribeiro, V, Amorim, S, Araujo, C, Torres, JP, Cardoso, JS, Pinho, P, Maciel, MJ, Storsten, P, Eriksen, M, Boe, E, Estensen, ME, Erikssen, G, Smiseth, OA, Skulstad, H, Miglioranza, MH, Gargani, L, Sant`Anna, RT, Rover, M, Martins, VM, Mantovanni, A, Kalil, RK, Leiria, TL, Luo, XX, Fang, F, Lee, PW, Zhang, ZH, Lam, YY, Sanderson, JE, Kwong, J SW, Yu, CM, Borowiec, A, Dabrowski, R, Wozniak, J, Jasek, S, Chwyczko, T, Kowalik, I, Janas, J, Musiej-Nowakowska, E, Szwed, H, Palinsky, M, Petrovicova, J, Pirscova, M, Baricevic, Z, Lovric, D, Cikes, M, Skoric, B, Ljubas Macek, J, Reskovic Luksic, V, Separovic Hanzevacki, J, Milicic, D, Elmissiri, AM, El Shahid, GS, Abdal-Wahhab, S, Vural, M G, Yilmaz, M, Cetin, S, Akdemir, R, Yoldas, T K, Yeter, E, Karamanou, AG, Hamodraka, ES, Lekakis, IA, Paraskevaidis, IA, Kremastinos, DT, Appiah-Dwomoh, E K, Wang, VC, Otto, C, Mayar, F, Bonaventura, K, Sunman, H, Canpolat, U, Kuyumcu, M, Yorgun, H, Sahiner, L, and Ozer, N

Abstract

Purpose: It is known the higher prevalence of structural heart disease in HIV patients, mostly diastolic dysfunction and pulmonary hypertension. In spite of that, there are few data about predisposing factors. Our objective was to evaluate whether HIV stage or detectable blood viral load correlate with the degree of heart disease. Methods: We conducted a prospective cohort study with HIV patients monitored by the internal medicine unit of our institution. We selected symptomatic patients with functional class ≥ II of NYHA scale. Viral blood load and CD4 count were systematically determined in order to obtain the HIV stage. Patients underwent a transthoracic echocardiogram to assess ventricular hypertrophy, systolic and diastolic dysfunction and pulmonary hypertension, according to the limits set by ESC guidelines. Results: Data were obtained from 65 HIV patients with dyspnea (63% male) with a mean age of 48 years. 50% were in NYHA grade II, 32.3% III and 17.7% IV. 46.7% of patients had some data of structural heart disease (figure). Belong to AIDS group (65.3%) did not correlate with the degree of heart disease. However, patients with positive blood viral load had a significantly higher incidence of structural heart disease than those with undetectable load (75% vs. 43% p <0.04), independent of their cardiovascular risk profile or type of antiretroviral therapy (Table). Conclusion: In our experience, half of HIV patients with dyspnea show echocardiographic data of structural heart disease. Detectable viral load in blood doubles the prevalence of heart disease, so that HIV itself may be an independent causal agent. These data should be taken into account in the screening of structural heart disease in these patients. Figure Prevalence of structural heart disease

Published
2013
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37. Poster session Friday 13 December - PM: 13/12/2013, 14:00-18:00 * Location: Poster area

Author

Caiani, EG, Pellegrini, A, Carminati, MC, Lang, RM, Auricchio, A, Vaida, P, Obase, K, Sakakura, T, Komeda, M, Okura, H, Yoshida, K, Zeppellini, R, Noni, M, Rigo, T, Erente, G, Carasi, M, Costa, A, Ramondo, BA, Thorell, L, Akesson-Lindow, T, Shahgaldi, K, Germanakis, I, Fotaki, A, Peppes, S, Sifakis, S, Parthenakis, F, Makrigiannakis, A, Richter, U, Sveric, K, Forkmann, M, Wunderlich, C, Strasser, RH, Djikic, D, Potpara, T, Polovina, M, Marcetic, Z, Peric, V, Ostenfeld, E, Werther-Evaldsson, A, Engblom, H, Ingvarsson, A, Roijer, A, Meurling, C, Holm, J, Radegran, G, Carlsson, M, Tabuchi, H, Yamanaka, T, Katahira, Y, Tanaka, M, Kurokawa, T, Nakajima, H, Ohtsuki, S, Saijo, Y, Yambe, T, Dalto, M, Romeo, E, Argiento, P, Dandrea, A, Vanderpool, R, Correra, A, Sarubbi, B, Calabro, R, Russo, MG, Naeije, R, Saha, S K, Warsame, T A, Caelian, A G, Malicse, M, Kiotsekoglou, A, Omran, A S, Sharif, D, Sharif-Rasslan, A, Shahla, C, Khalil, A, Rosenschein, U, Erturk, M, Oner, E, Kalkan, AK, Pusuroglu, H, Ozyilmaz, S, Akgul, O, Aksu, HU, Akturk, F, Celik, O, Uslu, N, Bandera, F, Pellegrino, M, Generati, G, Donghi, V, Alfonzetti, E, Guazzi, M, Rangel, I, Goncalves, A, Sousa, C, Correia, AS, Martins, E, Silva-Cardoso, J, Macedo, F, Maciel, MJ, Lee, S, Kim, W, Yun, H, Jung, L, Kim, E, Ko, J, Enescu, OA, Florescu, M, Rimbas, RC, Cinteza, M, Vinereanu, D, Kosmala, W, Rojek, A, Cielecka-Prynda, M, Laczmanski, L, Mysiak, A, Przewlocka-Kosmala, M, Liu, D, Hu, K, Niemann, M, Herrmann, S, Cikes, M, Gaudron, PD, Knop, S, Ertl, G, Bijnens, B, Weidemann, F, Saravi, M, Tamadoni, AHMAD, Jalalian, ROZITA, Hojati, MOSTAF, Ramezani, SAEED, Yildiz, A, Inci, U, Bilik, MZ, Yuksel, M, Oyumlu, M, Kayan, F, Ozaydogdu, N, Aydin, M, Akil, MA, Tekbas, E, Shang, Q, Zhang, Q, Fang, F, Wang, S, Li, R, Lee, A PW, Yu, CM, Mornos, C, Ionac, A, Cozma, D, Popescu, I, Ionescu, G, Dan, R, Petrescu, L, Sawant, AC, Srivatsa, SV, Adhikari, P, Mills, PK, Srivatsa, SS, Boshchenko, A, Vrublevsky, A, Karpov, R, Trifunovic, D, Stankovic, S, Vujisic-Tesic, B, Petrovic, M, Nedeljkovic, I, Banovic, M, Tesic, M, Petrovic, M, Dragovic, M, Ostojic, M, Zencirci, E, Esen Zencirci, A, Degirmencioglu, A, Karakus, G, Ekmekci, A, Erdem, A, Ozden, K, Erer, HB, Akyol, A, Eren, M, Zamfir, D, Tautu, O, Onciul, S, Marinescu, C, Onut, R, Comanescu, I, Oprescu, N, Iancovici, S, Dorobantu, M, Melao, F, Pereira, M, Ribeiro, V, Oliveira, S, Araujo, C, Subirana, I, Marrugat, J, Dias, P, Azevedo, A, study, EURHOBOP, Grillo, M T, Piamonti, B, Abate, E, Porto, A, Dellangela, L, Gatti, G, Poletti, A, Pappalardo, A, Sinagra, G, Pinto-Teixeira, P, Galrinho, A, Branco, L, Fiarresga, A, Sousa, L, Cacela, D, Portugal, G, Rio, P, Abreu, J, Ferreira, R, Fadel, B, Abdullah, N, Al-Admawi, M, Pergola, V, Bech-Hanssen, O, Di Salvo, G, Tigen, M K, Pala, S, Karaahmet, T, Dundar, C, Bulut, M, Izgi, A, Esen, A M, Kirma, C, Boerlage-Van Dijk, K, Yamawaki, M, Wiegerinck, EMA, Meregalli, PG, Bindraban, NR, Vis, MM, Koch, KT, Piek, JJ, Bouma, BJ, Baan, J, Mizia, M, Sikora-Puz, A, Gieszczyk-Strozik, K, Lasota, B, Chmiel, A, Chudek, J, Jasinski, M, Deja, M, Mizia-Stec, K, Silva Fazendas Adame, P R, Caldeira, D, Stuart, B, Almeida, S, Cruz, I, Ferreira, A, Lopes, L, Joao, I, Cotrim, C, Pereira, H, Unger, P, Dedobbeleer, C, Stoupel, E, Preumont, N, Argacha, JF, Berkenboom, G, Van Camp, G, Malev, E, Reeva, S, Vasina, L, Pshepiy, A, Korshunova, A, Timofeev, E, Zemtsovsky, E, Jorgensen, P G, Jensen, JS, Fritz-Hansen, T, Biering-Sorensen, T, Jons, C, Olsen, NT, Henri, C, Magne, J, Dulgheru, R, Laaraibi, S, Voilliot, D, Kou, S, Pierard, L, Lancellotti, P, Tayyareci, Y, Dworakowski, R, Kogoj, P, Reiken, J, Kenny, C, Maccarthy, P, Wendler, O, Monaghan, MJ, Song, JM, Ha, TY, Jung, YJ, Seo, MO, Choi, SA, Kim, YJ, Sun, BJ, Kim, DH, Kang, DH, Song, JK, Le Tourneau, T, Topilsky, Y, Inamo, J, Mahoney, D, Suri, R, Schaff, H, Enriquez-Sarano, M, Bonaque Gonzalez, JC, Sanchez Espino, AD, Merchan Ortega, G, Bolivar Herrera, N, Ikuta, I, Macancela Quinonez, JJ, Munoz Troyano, S, Ferrer Lopez, R, Gomez Recio, M, Dreyfus, J, Cimadevilla, C, Brochet, E, Himbert, D, Iung, B, Vahanian, A, Messika-Zeitoun, D, Izumo, M, Takeuchi, M, Seo, Y, Yamashita, E, Suzuki, K, Ishizu, T, Sato, K, Aonuma, K, Otsuji, Y, Akashi, YJ, Muraru, D, Addetia, K, Veronesi, F, Corsi, C, Mor-Avi, V, Yamat, M, Weinert, L, Lang, RM, Badano, LP, Minamisawa, M, Koyama, J, Kozuka, A, Motoki, H, Izawa, A, Tomita, T, Miyashita, Y, Ikeda, U, Florescu, C, Niemann, M, Liu, D, Hu, K, Herrmann, S, Gaudron, PD, Scholz, F, Stoerk, S, Ertl, G, Weidemann, F, Marchel, M, Serafin, A, Kochanowski, J, Piatkowski, R, Madej-Pilarczyk, A, Filipiak, KJ, Hausmanowa-Petrusewicz, I, Opolski, G, Meimoun, P, Mbarek, D, Clerc, J, Neikova, A, Elmkies, F, Tzvetkov, B, Luycx-Bore, A, Cardoso, C, Zemir, H, Mansencal, N, Arslan, M, El Mahmoud, R, Pilliere, R, Dubourg, O, Ikonomidis, I, Lambadiari, V, Pavlidis, G, Koukoulis, C, Kousathana, F, Varoudi, M, Tritakis, V, Triantafyllidi, H, Dimitriadis, G, Lekakis, I, Kovacs, A, Kosztin, A, Solymossy, K, Celeng, C, Apor, A, Faludi, M, Berta, K, Szeplaki, G, Foldes, G, Merkely, B, Kimura, K, Daimon, M, Nakajima, T, Motoyoshi, Y, Komori, T, Nakao, T, Kawata, T, Uno, K, Takenaka, K, Komuro, I, Gabric, I D, Vazdar, LJ, Pintaric, H, Planinc, D, Vinter, O, Trbusic, M, Bulj, N, Nobre Menezes, M, Silva Marques, J, Magalhaes, R, Carvalho, V, Costa, P, Brito, D, Almeida, AG, Nunes-Diogo, AG, Davidsen, E S, Bergerot, C, Ernande, L, Barthelet, M, Thivolet, S, Decker-Bellaton, A, Altman, M, Thibault, H, Moulin, P, Derumeaux, G, Huttin, O, Voilliot, D, Frikha, Z, Aliot, E, Venner, C, Juilliere, Y, Selton-Suty, C, Yamada, T, Ooshima, M, Hayashi, H, Okabe, S, Johno, H, Murata, H, Charalampopoulos, A, Tzoulaki, I, Howard, LS, Davies, RJ, Gin-Sing, W, Grapsa, J, Wilkins, MR, Gibbs, JSR, Castillo, JMDC, Bandeira, AMPB, Albuquerque, ESA, Silveira, C, Pyankov, V, Chuyasova, Y, Lichodziejewska, B, Goliszek, S, Kurnicka, K, Dzikowska Diduch, O, Kostrubiec, M, Krupa, M, Grudzka, K, Ciurzynski, M, Palczewski, P, Pruszczyk, P, Arana, X, Oria, G, Onaindia, JJ, Rodriguez, I, Velasco, S, Cacicedo, A, Palomar, S, Subinas, A, Zumalde, J, Laraudogoitia, E, Saeed, S, Kokorina, MV, Fromm, A, Oeygarden, H, Waje-Andreassen, U, Gerdts, E, Gomez, ELENA, Vallejo, NURIA, Pedro-Botet, LUISA, Mateu, LOURDE, Nunyez, RAQUEL, Llobera, LAIA, Bayes, ANTONI, Sabria, MIQUEL, Antonini-Canterin, F, Mateescu, AD, La Carrubba, S, Vriz, O, Di Bello, V, Carerj, S, Zito, C, Ginghina, C, Popescu, BA, Nicolosi, GL, Mateescu, AD, La Carrubba, S, Vriz, O, Di Bello, V, Carerj, S, Zito, C, Ginghina, C, Popescu, BA, Nicolosi, GL, Antonini-Canterin, F, Pudil, R, Praus, R, Vasatova, M, Vojacek, J, Palicka, V, Hulek, P, P37/03, Prvouk, Pradel, S, Mohty, D, Damy, T, Echahidi, N, Lavergne, D, Virot, P, Aboyans, V, Jaccard, A, Mateescu, AD, La Carrubba, S, Vriz, O, Di Bello, V, Carerj, S, Zito, C, Ginghina, C, Popescu, BA, Nicolosi, GL, Antonini-Canterin, F, Doulaptsis, C, Symons, R, Matos, A, Florian, A, Masci, PG, Dymarkowski, S, Janssens, S, Bogaert, J, Lestuzzi, C, Moreo, A, Celik, S, Lafaras, C, Dequanter, D, Tomkowski, W, De Biasio, M, Cervesato, E, Massa, L, Imazio, M, Watanabe, N, Kijima, Y, Akagi, T, Toh, N, Oe, H, Nakagawa, K, Tanabe, Y, Ikeda, M, Okada, K, Ito, H, Milanesi, O, Biffanti, R, Varotto, E, Cerutti, A, Reffo, E, Castaldi, B, Maschietto, N, Vida, VL, Padalino, M, Stellin, G, Bejiqi, R, Retkoceri, R, Bejiqi, H, Retkoceri, A, Surdulli, SH, Massoure, PL, Cautela, J, Roche, NC, Chenilleau, MC, Gil, JM, Fourcade, L, Akhundova, A, Cincin, A, Sunbul, M, Sari, I, Tigen, MK, Basaran, Y, Suermeci, G, Butz, T, Schilling, IC, Sasko, B, Liebeton, J, Van Bracht, M, Tzikas, S, Prull, MW, Wennemann, R, Trappe, HJ, Attenhofer Jost, C H, Pfyffer, M, Scharf, C, Seifert, B, Faeh-Gunz, A, Naegeli, B, Candinas, R, Medeiros-Domingo, A, Wierzbowska-Drabik, K, Roszczyk, N, Sobczak, M, Plewka, M, Krecki, R, Kasprzak, JD, Ikonomidis, I, Varoudi, M, Papadavid, E, Theodoropoulos, K, Papadakis, I, Pavlidis, G, Triantafyllidi, H, Anastasiou - Nana, M, Rigopoulos, D, Lekakis, J, Tereshina, O, Surkova, E, Vachev, A, Merchan Ortega, G, Bonaque Gonzalez, JC, Sanchez Espino, AD, Bolivar Herrera, N, Bravo Bustos, D, Ikuta, I, Aguado Martin, MJ, Navarro Garcia, F, Ruiz Lopez, F, Gomez Recio, M, Merchan Ortega, G, Bonaque Gonzalez, JC, Bravo Bustos, D, Sanchez Espino, AD, Bolivar Herrera, N, Bonaque Gonzalez, JJ, Navarro Garcia, F, Aguado Martin, MJ, Ruiz Lopez, MF, Gomez Recio, M, Eguchi, H, Maruo, T, Endo, K, Nakamura, K, Yokota, K, Fuku, Y, Yamamoto, H, Komiya, T, Kadota, K, Mitsudo, K, Nagy, A I, Manouras, AI, Gunyeli, E, Shahgaldi, K, Winter, R, Hoffmann, R, Barletta, G, Von Bardeleben, S, Kasprzak, J, Greis, C, Vanoverschelde, J, Becher, H, Hu, K, Liu, D, Niemann, M, Herrmann, S, Cikes, M, Gaudron, PD, Knop, S, Ertl, G, Bijnens, B, Weidemann, F, Di Salvo, G, Al Bulbul, Z, Issa, Z, Khan, AM, Faiz, AA, Rahmatullah, SH, Fadel, BM, Siblini, G, Al Fayyadh, M, Menting, M E, Van Den Bosch, AE, Mcghie, JS, Cuypers, JAAE, Witsenburg, M, Van Dalen, BM, Geleijnse, ML, Roos-Hesselink, JW, Olsen, FJ, Jorgensen, PG, Mogelvang, R, Jensen, JS, Fritz-Hansen, T, Bech, J, Biering-Sorensen, T, Agoston, G, Pap, R, Saghy, L, Forster, T, Varga, A, Scandura, S, Capodanno, D, Dipasqua, F, Mangiafico, S, Caggegi, A M, Grasso, C, Pistritto, A M, Imme, S, Ministeri, M, Tamburino, C, Cameli, M, Lisi, M, Dascenzi, F, Cameli, P, Losito, M, Sparla, S, Lunghetti, S, Favilli, R, Fineschi, M, Mondillo, S, Ojaghihaghighi, Z, Javani, B, Haghjoo, M, Moladoust, H, Shahrzad, S, Ghadrdoust, B, Altman, M, Aussoleil, A, Bergerot, C, Bonnefoy-Cudraz, E, Derumeaux, G A, Thibault, H, Shkolnik, E, Vasyuk, Y, Nesvetov, V, Shkolnik, L, Varlan, G, Gronkova, N, Kinova, E, Borizanova, A, Goudev, A, Saracoglu, E, Ural, D, Sahin, T, Al, N, Cakmak, H, Akbulut, T, Akay, K, Ural, E, Mushtaq, S, Andreini, D, Pontone, G, Bertella, E, Conte, E, Baggiano, A, Annoni, A, Formenti, A, Fiorentini, C, Pepi, M, Cosgrove, C, Carr, L, Chao, C, Dahiya, A, Prasad, S, Younger, JF, Biering-Sorensen, T, Christensen, LM, Krieger, DW, Mogelvang, R, Jensen, JS, Hojberg, S, Host, N, Karlsen, FM, Christensen, H, Medressova, A, Abikeyeva, L, Dzhetybayeva, S, Andossova, S, Kuatbayev, Y, Bekbossynova, M, Bekbossynov, S, Pya, Y, Farsalinos, K, Tsiapras, D, Kyrzopoulos, S, Spyrou, A, Stefopoulos, C, Romagna, G, Tsimopoulou, K, Tsakalou, M, Voudris, V, Cacicedo, A, Velasco Del Castillo, S, Anton Ladislao, A, Aguirre Larracoechea, U, Onaindia Gandarias, J, Romero Pereiro, A, Arana Achaga, X, Zugazabeitia Irazabal, G, Laraudogoitia Zaldumbide, E, Lekuona Goya, I, Varela, A, Kotsovilis, S, Salagianni, M, Andreakos, V, Davos, CH, Merchan Ortega, G, Bonaque Gonzalez, JC, Sanchez Espino, AD, Bolivar Herrera, N, Macancela Quinones, JJ, Ikuta, I, Ferrer Lopez, R, Munoz Troyano, S, Bravo Bustos, D, and Gomez Recio, M

Abstract

Purpose: Cardiac deconditioning due to immobilization is a risk factor for cardiovascular disease. The physiology of cardiac adaptation to deconditioning has not been fully elucidated. The purpose of the present study was to assess the effects of 21-days of strict head-down (-6 degrees) bed-rest (BR) deconditioning on left ventricular (LV) dimensions and mass measured by MRI. Methods: Ten healthy men (mean age 32±6) were enrolled; the experiment was conducted at DLR (Koln, Germany) as part of the European Space Agency BR studies. Steady-state free precession MRI images (7mm thickness, no gap, no overlap) were obtained (Symphony 1.5T, Siemens) in a stack of short-axis views from LV base to LV apex, before (PRE), at the end of BR (HDT20), and four days after the BR conclusion (POST). Endocardial and epicardial semi-automated contouring was performed using freely available software (Segment). Results: At HDT20, significant reductions in LV mass (16%), end-diastolic (26%) and end-systolic (27%) volumes and stroke volume (27%) were observed, while ejection fraction did not change. These changes were accompanied by a measured decrease (14%) in plasma and blood volume (by gas-rebreathing technique), as well as by a significant reduction (14%) in VO2max aerobic power, measured using a graded cycle ergometer test protocol to volitional fatigue, at one day after the BR conclusion, while expiratory exchange ratio did not change. At POST, LV volumes were restored, while LV mass was still trending towards control values. Conclusions: Cardiac adaptation to deconditioning affected LV mass and dimensions, as a combined result of LV remodeling and fluids loss, accompanied by worsening in aerobic power. This should be taken into account in patients with cardiovascular diseases, when immobilized in bed, to proper adjust the therapy, or to define appropriate physical exercises when possible, in order to avoid further complications.   Cardiac MRI parameters PREHDT20POSTLV mass (g)121±6102±11*114±16End-diastolic volume (ml)119±2590±14*118±25End-systolic volume (ml)42±831±8*45±14Stroke volume (ml)76±2259±11*73±15Ejection fraction (%)64±665±762±7 *: p<.01 vs PRE (one-way Anova for paired data and Tukey test)

Published
2013
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38. The impact of dominant ventricle morphology and additional ventricular chamber size on clinical outcomes in patients with Fontan circulation.

Author

Padalino MA, Ponzoni M, Reffo E, Azzolina D, Cavaliere A, Puricelli F, Cabrelle G, Bergonzoni E, Cao I, Gozzi A, Castaldi B, Vida V, and Di Salvo G

Abstract

Objectives: The functional roles of ventricular dominance and additional ventricular chamber after Fontan operation are still uncertain. We aim to assess and correlate such anatomical features to late clinical outcomes., Methods: Fontan patients undergoing cardiac MRI and cardiopulmonary exercise test between January 2020 and December 2022 were retrospectively reviewed. Clinical, cardiac MRI, and cardiopulmonary exercise test data from the last follow-up were analysed., Results: Fifty patients were analysed: left dominance was present in 29 patients (58%, median age 20 years, interquartile range:16-26). At a median follow-up after the Fontan operation was 16 years (interquartile range: 4-42), NYHA classes III and IV was present in 3 patients (6%), 4 (8%) underwent Fontan conversion, 2 (4%) were listed for heart transplantation, and 2 (4%) died. Statistical analysis showed that the additional ventricular chamber was larger (>20 mL/m 2 ) in patients with a right dominant ventricle ( p = 0.01), and right dominance was associated with a higher incidence of post-operative low-cardiac output syndrome ( p = 0.043). Left ventricular dominance was associated with a better ejection fraction ( p = 0.04), less extent of late gadolinium enhancement ( p = 0.022), higher metabolic equivalents ( p = 0.01), and higher peak oxygen consumption ( p = 0.033). A larger additional ventricular chamber was associated with a higher need for post-operative extracorporeal membrane oxygenation support ( p = 0.007), but it did not influence functional parameters on cardiac MRI or cardiopulmonary exercise test., Conclusions: In Fontan patients, left ventricular dominance correlated to better functional outcomes. Conversely, a larger additional ventricular chamber is more frequent in right ventricular dominance and can negatively affect the early post-Fontan course.

Published
2024
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39. The Sub-Pulmonary Left Ventricle in Patients with Systemic Right Ventricle, the Paradoxical Neglected Chamber: A Cardiac Magnetic Resonance Feature Tracking Study.

Author

Piana S, Pozza A, Cavaliere A, Molinaroli A, Cattapan I, Fumanelli J, Avesani M, Reffo E, and Di Salvo G

Abstract

Background/Objective : The impact of subpulmonary left ventricle (LV) dysfunction in patients with a systemic right ventricle (SRV) is insufficiently characterized, with only a few studies suggesting its prognostic significance. Additionally, its evaluation through imaging techniques is a challenge. To assess the correlation between quantitative cardiac magnetic resonance-feature tracking (CMR-FT) data and the risk of clinical events related to the natural history of SRV failure. Methods : In this cross-sectional study, 21 patients with a diagnosis of transposition of the great arteries (TGA) and atrial switch operation (AtSO) or congenitally corrected transposition (ccTGA) were recruited. All participants underwent CMR-FT analysis. Considered clinical events included NYHA class deterioration (from I-II to III-IV), increased diuretic therapy, arrhythmias, sudden cardiac death, and hospitalizations. Results : The cohort consisted of 52.4% males (mean age: 25.4 ± 11.9 years). Eleven patients were diagnosed with ccTGA. Of the 10 patients with TGA post-AtSO, 50% had undergone Mustard repair. Clinical events occurred in 11 patients, with 47.6% experiencing hospitalizations and 28.6% developing arrhythmias. Left ventricular global longitudinal strain (LV GLS) was significantly associated with event-risk in both univariate and multivariate analyses ( p = 0.011; p = 0.025). A cut-off value of LV GLS > -19.24 was proposed to stratify high-risk patients ( p = 0.001). Conclusions : Our study confirms the role of subpulmonary LV function in determining outcomes of SRV patients. The assessment of LV GLS by using CMR-FT could significantly enhance clinical management during follow-up.

Published
2024
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40. Multimodality imaging and functional assessment in patients with systemic right ventricle and biventricular physiology: a retrospective single-center study.

Author

Pozza A, Avesani M, Cattapan I, Reffo E, Cavaliere A, Sabatino J, Piana S, Molinaroli A, Sirico D, Castaldi B, Cerutti A, Biffanti R, and Di Salvo G

Subjects
Humans, Retrospective Studies, Male, Female, Adult, Heart Ventricles diagnostic imaging, Heart Ventricles physiopathology, Echocardiography, Three-Dimensional methods, Stroke Volume physiology, Congenitally Corrected Transposition of the Great Arteries, Ventricular Function, Right physiology, Magnetic Resonance Imaging methods, Young Adult, Exercise Tolerance physiology, Middle Aged, Adolescent, Echocardiography methods, Arterial Switch Operation adverse effects, Arterial Switch Operation methods, Ventricular Dysfunction, Right diagnostic imaging, Ventricular Dysfunction, Right physiopathology, Transposition of Great Vessels diagnostic imaging, Transposition of Great Vessels physiopathology, Multimodal Imaging methods
Abstract

Systemic right ventricle (sRV) dysfunction is frequent in patients with congenitally corrected transposition of great arteries (cc-TGA) and those with dextro-transposition of great arteries (D-TGA) after Mustard/Senning operations. This condition should be identified promptly. We aimed to compare echocardiographic parameters with cardiac magnetic resonance (CMR)-derived parameters in patients with sRV and to evaluate their correlation with clinical variables and exercise capacity. Patients with cc-TGA and D-TGA after Mustard/Senning who underwent standard and advanced (speckle tracking and 3D) echocardiography and CMR (including feature-speckle tracking) were included. Clinical and imaging parameters were collected. Echocardiographic-derived right ventricle end-diastolic area and end-systolic area correlated with 3D echocardiographic-derived right ventricle end-diastolic and end-systolic volume (r=0.6, p=0.006 and r=0.8, p=0.002). 3D ejection fraction (EF) correlated with fractional area change and tricuspid annular plane systolic excursion (TAPSE) (r=0.8, p=0.001 and r=0.7, p=0.03). sRV global longitudinal strain (GLS) correlated with systemic atrial strain (sAS) (r=-0.6, p=0.01). CMR-derived EF correlated with CMR-derived GLS both endocardial and myocardial (r=-0.7, p=0.007 and r=-0.6, p=0.005). sRV areas as assessed by echo correlated with CMR-derived volumes (r=0.9, p=0.0001 for diastole and r=0.8, p=0.0001 for systole). Similarly, a correlation was found between sRV echo-derived GLS and CMR-derived GLS, both endocardial and myocardial (r=0.8, p=0.001 and r=0.7, p=0.01). The only imaging parameter that correlated with peak oxygen consumption was sAS (r=0.55, p=0.04). When comparing cc-TGA and D-TGA, the former showed better GLS-derived values as assessed by CMR (CMR-derived right ventricle endocardial longitudinal strain -23.2% versus -17.2%, p=0.002; CMR-derived right ventricle myocardial longitudinal strain -21.2% versus -16.7%; p=0.05), bigger systemic atrial area (20.2 cm2/m2 versus 8.4 cm2/m2, p=0.005) and higher TAPSE values (16.2 mm versus 12.2 mm, p=0.04). Echocardiography is valid to screen for sRV dilatation and function and to guide the timing for CMR. The investigation of atrial deformation imaging may help to better understand diastolic function. Patients with cc-TGA show better cardiac function compared to patients after atrial switch. Further investigations are needed to identify imaging parameters linked to exercise capacity.

Published
2024
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41. How effective is disopyramide in treating pediatric hypertrophic cardiomyopathy? State of the art and future directions.

Author

Del Vecchio K, Rizzardi C, Pozza A, Prati F, Ye L, Fattoretto A, Reffo E, and Di Salvo G

Subjects
Humans, Child, Adolescent, Ventricular Outflow Obstruction drug therapy, Quality of Life, Anti-Arrhythmia Agents therapeutic use, Electrocardiography, Child, Preschool, Infant, Treatment Outcome, Adult, Cardiomyopathy, Hypertrophic drug therapy, Cardiomyopathy, Hypertrophic physiopathology, Disopyramide therapeutic use, Echocardiography
Abstract

Pediatric hypertrophic cardiomyopathy (HCM) has a wide range of clinical manifestations. Left ventricular outflow tract obstruction (LVOTO) at rest is present in up to one-third of children with HCM, with a further 50-60% of symptomatic children developing a gradient under exertion. Treatment options are limited, and there is a relative lack of data on the pediatric population. Disopyramide is a sodium channel blocker with negative inotropic properties. This therapy effectively reduces LVOTO in adults with HCM and delays surgical interventions, but it is not licensed for use in children. We aimed to review and analyze the influence of disopyramide over the pathophysiological, clinical, electrocardiographic, and echocardiographic characteristics of patients with HCM in infancy, childhood, adolescence, and adult age. While disopyramide remains a cornerstone in the management of pediatric HCM, the advent of mavacamten and aficamten heralds a new era of potential advancements. These emerging therapies could significantly improve the quality of life and prognosis for young patients with HCM.

Published
2024
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42. Importance of Cardiovascular Magnetic Resonance Applied to Congenital Heart Diseases in Pediatric Age: A Narrative Review.

Author

Moscatelli S, Pozza A, Leo I, Ielapi J, Scatteia A, Piana S, Cavaliere A, Reffo E, and Di Salvo G

Abstract

Congenital heart diseases (CHDs) represent a heterogeneous group of congenital defects, with high prevalence worldwide. Non-invasive imaging is essential to guide medical and surgical planning, to follow the patient over time in the evolution of the disease, and to reveal potential complications of the chosen treatment. The application of cardiac magnetic resonance imaging (CMRI) in this population allows for obtaining detailed information on the defects without the necessity of ionizing radiations. This review emphasizes the central role of CMR in the overall assessment of CHDs, considering also the limitations and challenges of this imaging technique. CMR, with the application of two-dimensional (2D) and tri-dimensional (3D) steady-state free precession (SSFP), permits the obtaining of very detailed and accurate images about the cardiac anatomy, global function, and volumes' chambers, giving essential information in the intervention planning and optimal awareness of the postoperative anatomy. Nevertheless, CMR supplies tissue characterization, identifying the presence of fat, fibrosis, or oedema in the myocardial tissue. Using a contrast agent for angiography sequences or 2D/four-dimensional (4D) flows offers information about the vascular, valvular blood flow, and, in general, the cardiovascular system hemodynamics. Furthermore, 3D SSFP CMR acquisitions allow the identification of coronary artery abnormalities as an alternative to invasive angiography and cardiovascular computed tomography (CCT). However, CMR requires expertise in CHDs, and it can be contraindicated in patients with non-conditional devices. Furthermore, its relatively longer acquisition time and the necessity of breath-holding may limit its use, particularly in children under eight years old, sometimes requiring anesthesia. The purpose of this review is to elucidate the application of CMR during the pediatric age.

Published
2024
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43. Percutaneous approach to residual pulmonary bifurcation stenosis in conotruncal diseases.

Author

Castaldi B, Di Candia A, Cuppini E, Sirico D, Reffo E, Padalino M, Vida V, and Di Salvo G

Subjects
Adult, Child, Humans, Constriction, Pathologic surgery, Retrospective Studies, Treatment Outcome, Stents, Coronary Angiography, Angioplasty, Balloon, Coronary, Pulmonary Valve Stenosis surgery
Abstract

Residual stenosis after right ventricle outflow tract surgery represents a major issue to manage in the children and adult patient with conotruncal defects. Despite a detailed multimodality imaging, the anatomy of distal pulmonary trunk and pulmonary artery bifurcation may be challenging in these patients.The aim of this study was to analyse retrospectively the outcome of the percutaneous transcatheter treatment in children with post-surgical stenosis of pulmonary artery bifurcation.We enrolled 39 patients with a median age of 6.0 years. Standard high-pressure balloon dilation was attempted in 33 patients, effective in 5 of them. Pulmonary branch stenting was performed in 10 patients, effective in 6. A kissing balloon approach was chosen in 17 patients (6 after angioplasty or stenting failure), and this technique was effective in 16 cases. Finally, a bifurcation stenting was performed in 10 patients (second step in 9 cases), effective in all the cases. None of the patients approached by kissing balloon needed a bifurcation stenting.In conclusion, standard balloon angioplasty and standard stenting might be ineffective in post-surgical stenosis involving pulmonary artery bifurcation. In this population, kissing balloon or bifurcation stenting, followed by side branch de-jailing, may be more effective in relieving the gradient.

Published
2024
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44. Utility of Fetal Cardiac Resonance Imaging in Prenatal Clinical Practice: Current State of the Art.

Author

Pozza A, Reffo E, Castaldi B, Cattapan I, Avesani M, Biffanti R, Cavaliere A, Cerutti A, and Di Salvo G

Abstract

The field of prenatal cardiac imaging has revolutionized the way we understand and manage congenital heart diseases (CHD) in the developing fetus. In the prenatal period, cardiac imaging plays a pivotal role in the diagnostic pathway, from screening to classification and follow-up of CHD. The ability to visualize the fetal heart in utero allows healthcare professionals to detect abnormalities early, thus enabling timely interventions and informed decision-making processes for both the mother and the medical team. Early CHD detection improves preparation for delivery, postnatal care, and postnatal outcomes. Advancements in medical technology and imaging techniques have provided clinicians with insights into the fascinating workings of the fetal heart. Several imaging modalities have proven to be helpful in this field, with echocardiography undoubtedly representing the primary modality for evaluating the fetus. By providing detailed anatomical and functional information, fetal cardiac magnetic resonance (CMR) imaging contributes to better prenatal counseling and enhances the coordination of care between obstetricians, maternal-fetal medicine specialists, and pediatric cardiologists. Shortcomings of fetal CMR are due to technical concerns related to the intrauterine position of the fetus and subsequent challenges to following a standard scan protocol. The aim of this paper was to revise the current state-of-the-art in the field of fetal CMR and its clinical applications and to delve into methods, challenges, and future directions of fetal CMR in prenatal imaging.

Published
2023
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45. Childhood Obesity and Congenital Heart Disease: A Lifelong Struggle.

Author

Di Salvo G, Cattapan I, Fumanelli J, Pozza A, Moscatelli S, Sabatino J, Avesani M, Reffo E, Sirico D, Castaldi B, Cerutti A, Biffanti R, and Pergola V

Abstract

Congenital heart disease (CHD) affects approximately one in every one hundred infants worldwide, making it one of the most prevalent birth abnormalities globally. Despite advances in medical technology and treatment choices, CHD remains a significant health issue and necessitates specialized care throughout an individual's life. Childhood obesity has emerged as a novel global epidemic, becoming a major public health issue, particularly in individuals with lifelong conditions such as CHD. Obesity has profound effects on cardiac hemodynamics and morphology, emphasizing the importance of addressing obesity as a significant risk factor for cardiovascular health. Obesity-induced alterations in cardiac function can have significant implications for cardiovascular health and may contribute to the increased risk of heart-related complications in obese individuals. Moreover, while diastolic dysfunction may be less apparent in obese children compared to adults, certain parameters do indicate changes in early left ventricular relaxation, suggesting that obesity can cause cardiac dysfunction even in pediatric populations. As most children with CHD now survive into adulthood, there is also concern about environmental and behavioral health risk factors in this particular patient group. Addressing obesity in individuals with CHD is essential to optimize their cardiovascular health and overall quality of life. This review aims to succinctly present the data on the impact of obesity on CHD and to enhance awareness of this perilous association among patients, families, and healthcare providers.

Published
2023
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46. Unveiling the gothic aortic arch and cardiac mechanics: insights from young patients after arterial switch operation for d-transposition of the great arteries.

Author

Pergola V, Avesani M, Reffo E, Da Pozzo S, Cavaliere A, Padalino M, Vida V, Motta R, and Di Salvo G

Subjects
Humans, Aorta, Thoracic diagnostic imaging, Aorta, Thoracic surgery, Aorta diagnostic imaging, Aorta surgery, Heart, Arterial Switch Operation adverse effects, Transposition of Great Vessels diagnostic imaging, Transposition of Great Vessels surgery, Transposition of Great Vessels etiology
Abstract

The arterial switch operation (ASO) has become the standard surgical treatment for patients with d-transposition of the great arteries. While ASO has significantly improved survival rates, a subset of patients develop a unique anatomical anomaly known as the gothic aortic arch (GAA). Understanding cardiac mechanics in this population is crucial, as altered mechanics can have profound consequences for cardiac function and exercise capacity. The GAA has been associated with changes in ventricular function, hemodynamics, and exercise capacity. Studies have shown a correlation between the GAA and decreased ascending aorta distensibility, loss of systolic wave amplitude across the aortic arch, and adverse cardiovascular outcomes. Various imaging techniques, including echocardiography, cardiac magnetic resonance imaging, and cardiac computed tomography, play a crucial role in assessing cardiac mechanics and evaluating the GAA anomaly. Despite significant advancements, gaps in knowledge regarding the prognostic implications and underlying mechanisms of the GAA anomaly remain. This review aims to explore the implications of the GAA anomaly on cardiac mechanics and its impact on clinical outcomes in young patients after ASO. Advancements in imaging techniques, such as computational modeling, offer promising avenues to enhance our understanding of cardiac mechanics and improve clinical management.

Published
2023
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47. Late left ventricular myocardial remodeling after pulmonary artery banding for end-stage dilated cardiomyopathy in infants: an imaging study.

Author

Ponzoni M, Zanella L, Reffo E, Cavaliere A, Pozza A, Castaldi B, Di Salvo G, Vida VL, and Padalino MA

Subjects
Child, Humans, Infant, Ventricular Remodeling physiology, Pulmonary Artery diagnostic imaging, Pulmonary Artery surgery, Ventricular Function, Left, Myocardium pathology, Fibrosis, Cardiomyopathy, Dilated diagnostic imaging, Cardiomyopathy, Dilated surgery, Cardiomyopathy, Dilated pathology
Abstract

Background: Understanding the macroscopic biventricular changes induced by pulmonary artery banding (PAB) in children with dilated cardiomyopathy (DCM) represents the first step to unraveling the regenerative potential of the myocardium. We herein investigated the phases of left ventricular (LV) rehabilitation in PAB responders, using a systematic echocardiographic and cardiac magnetic imaging (CMRI) surveillance protocol., Methods: We prospectively enrolled all patients with DCM treated with PAB from September-2015 at our institution. Among 9 patients, 7 positively responded to PAB and were selected. Transthoracic 2D echocardiography was performed before PAB; and 30, 60, 90, and 120 days after PAB; and at the last available follow-up. CMRI was performed before PAB (whenever possible) and one year after PAB., Results: In PAB responders, LV ejection fraction showed a modest 10% increase 30-60 days after PAB, followed by its almost complete normalization after 120  days (median of 20[10-26]% vs 56[44.5-63.5]%, at baseline and 120 days after PAB, respectively). Parallelly, the LV end-diastolic volume decreased from a median of 146(87-204)ml/m2 to 48(40-50)ml/m2. At the last available follow-up (median of 1.5 years from PAB), both echocardiography and CMRI showed a sustained positive LV response, although myocardial fibrosis was detected in all patients., Conclusions: Echocardiography and CMRI show that PAB can promote a LV remodeling process, which starts slowly and can culminate in the normalization of LV contractility and dimensions 4 months later. These results are maintained up to 1.5 years. However, CMRI showed residual fibrosis as evidence of a past inflammatory injury whose prognostic significance is still uncertain., Competing Interests: Declaration of Competing Interest The authors report no relationships that could be construed as a conflict of interest., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Published
2023
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48. Three-Dimensional-Enabled Surgical Planning for the Correction of Right Partial Anomalous Pulmonary Venous Return.

Author

Cattapan C, Guariento A, Bifulco O, Caraffa R, Bertelli F, Reffo E, Padalino M, Di Salvo G, and Vida V

Abstract

Objectives: The surgical technique for right partial anomalous pulmonary venous return (PAPVR) depends on the location of the anomalous pulmonary veins (PVs). With this in mind, we sought to evaluate the impact of 3D heart segmentation and reconstruction on preoperative surgical planning. Methods: A retrospective study was conducted on all patients who underwent PAPVR repair at our institution between January 2018 and October 2021; three-dimensional segmentations and reconstructions of all the heart anatomies were performed. A score (the PAPVR score) was established and calculated using two anatomical parameters (the distance between the most cranial anomalous PV and the superior rim of the sinus venosus defect/the sum of the latter and the distance between the PV and the azygos vein) to predict the type of correction. Results: A total of 30 patients were included in the study. The PAPVR score was found to be a good predictor of the type of surgery performed. A value > 0.68 was significantly associated with a Warden procedure (p < 0.001) versus single/double patch repair. Conclusions: Three-dimensional heart segmentations and reconstructions improve the quality of surgical planning in the case of PAPVR and allow for the introduction of a score that may facilitate surgical decisions on the type of repair required.

Published
2023
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49. Mid- and Long-Term Atrio-Ventricular Functional Changes in Children after Recovery from COVID-19.

Author

Sabatino J, Di Chiara C, Di Candia A, Sirico D, Donà D, Fumanelli J, Basso A, Pogacnik P, Cuppini E, Romano LR, Castaldi B, Reffo E, Cerutti A, Biffanti R, Cozzani S, Giaquinto C, and Di Salvo G

Abstract

Background: Although most children may experience mild to moderate symptoms and do not require hospitalization, there are little data on cardiac involvement in COVID-19. However, cardiac involvement is accurately demonstrated in children with MISC. The objective of this study was to evaluate cardiac mechanics in previously healthy children who recovered from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in a long-term follow-up by means of two-dimensional speckle-tracking echocardiography (STE). Methods: We analyzed a cohort of 157 paediatric patients, mean age 7.7 ± 4.5 years (age range 0.3−18 years), who had a laboratory-confirmed diagnosis of SARS-CoV-2 infection and were asymptomatic or mildly symptomatic for COVID-19. Patients underwent a standard transthoracic echocardiogram and STE at an average time of 148 ± 68 days after diagnosis and were divided in three follow-up groups (<180 days, 180−240 days, >240 days). Patients were compared with 107 (41 females—38%) age- and BSA-comparable healthy controls (CTRL). Results: Left ventricular (LV) global longitudinal strain (post-COVID-19: −20.5 ± 2.9%; CTRL: −21.8 ± 1.7%; p < 0.001) was significantly reduced in cases compared with CTRLs. No significant differences were seen among the three follow-up groups (p = NS). Moreover, regional longitudinal strain was significantly reduced in LV apical-wall segments of children with disease onset during the second wave of the COVID-19 pandemic compared to the first wave (second wave: −20.2 ± 2.6%; first wave: −21.2 ± 3.4%; p = 0.048). Finally, peak left atrial systolic strain was within the normal range in the post-COVID-19 group with no significant differences compared to CTRLs. Conclusions: Our study demonstrated for the first time the persistence of LV myocardial deformation abnormalities in previously healthy children with an asymptomatic or mildly symptomatic (WHO stages 0 or 1) COVID-19 course after an average follow-up of 148 ± 68 days. A more significant involvement was found in children affected during the second wave. These findings imply that subclinical LV dysfunction may also be a typical characteristic of COVID-19 infection in children and are concerning given the predictive value of LV longitudinal strain in the general population.

Published
2022
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50. Long QT syndrome and left ventricular non-compaction in a family with KCNH2 mutation: A case report.

Author

Caiffa T, Tessitore A, Leoni L, Reffo E, Chicco D, D'Agata Mottolese B, Rubinato E, Girotto G, Lenarduzzi S, Barbi E, Bobbo M, and Di Salvo G

Abstract

Background: Left ventricular non-compaction (LVNC) is an abnormality of the myocardium, characterized by prominent left ventricular trabeculae and deep inter-trabecular recesses. Long QT syndrome (LQTS) is a cardiac ion channelopathy presenting with a prolonged QT interval on resting electrocardiogram and is associated with increased susceptibility to sudden death. The association between LVNC and LQTS is uncommon., Case Presentation: We report an Italian family with a novel pathogenic KCNH2 variant who presented with clinical features of LVNC and LQTS. The proband came to our attention after two syncopal episodes without prodromal symptoms. His ECG showed QTc prolongation and deep T wave inversion in anterior leads, and the echocardiogram fulfilled LVNC criteria. After that, also his sister was found to have LQTS and LVNC, while his father only presented LQTS., Conclusions: Physicians should be aware of the possible association between LVNC and LQTS. Even if this association is rare, patients with LVNC should be investigated for LQTS to prevent possible severe or even life-threatening arrhythmic episodes., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Caiffa, Tessitore, Leoni, Reffo, Chicco, D'Agata Mottolese, Rubinato, Girotto, Lenarduzzi, Barbi, Bobbo and Di Salvo.)

Published
2022
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