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202 results on '"Refaat, Amal"'

5. Plasma miRNA expression profile in pediatric pineal pure germinomas

Author

Fakhry, Mona, primary, Elayadi, Moatasem, additional, Elzayat, Mariam G., additional, Samir, Omar, additional, Maher, Eslam, additional, Taha, Hala, additional, El-Beltagy, Mohamed, additional, Refaat, Amal, additional, Zamzam, Manal, additional, Abdelbaki, Mohamed S., additional, Sayed, Ahmed A., additional, Kieran, Mark, additional, and Elhaddad, Alaa, additional

Published
2024
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18. Prognostic factors affecting infantile medulloblastoma outcomes in the molecular era: a 12-year single-center experience from Egypt

Author

El-Hemaly, Ahmed, primary, El-Ayadi, Moatasem, additional, Ahmed, Soha, additional, Taha, Hala, additional, Magdy, Marwa, additional, Refaat, Amal, additional, Ammar, Hany, additional, Maher, Eslam, additional, Badawy, Eman, additional, Rady, Mohamed, additional, El-Beltagy, Mohamed, additional, Zaghloul, Mohamed S, additional, and El-Haddad, Alaa, additional

Published
2023
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21. miRNA Expression Profile in Pediatric Pineal Pure Germinomas

Author

Fakhry, Mona, primary, Elayadi, Moatasem, additional, Elzayat, Mariam, additional, Samir, Omar, additional, Maher, Eslam, additional, Taha, Hala, additional, El-Beltagy, Mohamed, additional, Refaat, Amal, additional, Zamzam, Manal, additional, Abdelbaki, Mohamed S, additional, Sayed, Ahmed, additional, Kieran, Mark, additional, and Elhaddad, Alaa, additional

Published
2022
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42. Palliative and end-of-life symptoms management for children with diffuse intrinsic pontine glioma.

Author

Elhemaly, Ahmed, Refaey, Osama El, Rizkallah, Reda Samuel, Refaat, Amal, and Zaghloul, Mohamed Saad

Abstract

Background: This study aimed to investigate diffuse intrinsic pontine glioma-specific symptoms in the last 12 weeks before death and to describe current palliative care. Materials & methods: A retrospective study included 80 pediatric diffuse intrinsic pontine glioma patients diagnosed between January 2018 and December 2019. Results: The most frequently encountered symptoms were headache, gait disturbance, vomiting, dysphagia, sensory loss, seizures and constipation. Steroids were used in 96% of patients with a high success rate, as well as analgesics (67.5%), antiemetics (59%), neuropathic medication (42.5%) and anticonvulsants (37.5%). Re-irradiation improved symptoms in 50% of patients. Conclusion: Steroids were efficient in managing many symptoms, with tolerated side effects. The symptomatic treatment succeeded in relieving end-of-life symptoms. Re-irradiation should be considered a good palliative tool in addition to regular symptomatic treatment. This study aimed to describe symptoms in 80 patients with aggressive brain tumors in the brain stem, as well as proper management of the symptoms at the end of life. The symptoms encountered were headache, imbalance during walking, vomiting and fits. They were managed successfully with steroids, painkillers, nausea and vomiting medications and anti-fit medication. Giving radiotherapy for a second time improved symptoms in 50% of patients, and steroids can be used efficiently to improve the misery of these patients. These data can help to put a strategy for managing these devastating symptoms in the end-of-life period. [ABSTRACT FROM AUTHOR]

Published
2022
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43. The outcome of childhood adrenocortical carcinoma in Egypt: A model from developing countries

Author

Zekri, Wael, Hammad, Mahmoud, Rashed, Wafaa M., Gehad Ahmed, Elshafie, Maged, Adly, Marwan H., Elborai, Yasser, Abdalla, Badr, Taha, Hala, Naglaa Elkinaae, Refaat, Amal, Younis, Alaa, and Alfaar, Ahmad S.

Abstract

Adrenocortical carcinoma (ACC) is a rare, aggressive endocrine neoplasm. Complete surgical resection is the single most important treatment. Most available information has been learned from experience with its more frequent adult counterpart. In this study, we assessed the features and survival outcome of patients with ACC at Children’s Cancer Hospital Egypt (CCHE). Patients diagnosed at CCHE between July 2007 and November 2016 were followed up on until November 2018. Patients with stages I and II were operated upon, while stages III and IV had received combinations of doxorubicin, etoposide, platinol, and mitotane (DEPM) beside the attempt to conduct surgery when feasible. Data belonging to 18 patients (7 men and 11 women) were analyzed; median age at diagnosis was 48.5 months. Sixteen patients had presented with secreting tumors. Six patients were diagnosed with stage I disease; four with stage II; three with stage III; and five with stage IV carcinoma. By the end of this study, 10 patients have survived; five-year overall survival of 66.3%. Surviving patients were all of stage I or II diseases and were all in remission. Seven patients who did not survive died due to tumor progression, while one patient died after chemotherapy. The prognosis of ACC is essentially dependent on a successful complete resection of the tumor and thus on the initial tumor stage. The mitotane and DEP protocols may help control tumor growth in the advanced stages for only short periods. Key pointsInitial stage and resectability are the main indicators of outcomes in adrenocortical carcinoma.Chemotherapeutic agents used in developed countries did not achieve the same outcomes.Further molecular-pharmacology differentiation is needed for various ethnic populations. Initial stage and resectability are the main indicators of outcomes in adrenocortical carcinoma. Chemotherapeutic agents used in developed countries did not achieve the same outcomes. Further molecular-pharmacology differentiation is needed for various ethnic populations.

Published
2020
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45. The outcome of childhood adrenocortical carcinoma in Egypt: A model from developing countries

Author

Zekri, Wael, primary, Hammad, Mahmoud, additional, Rashed, Wafaa M., additional, Ahmed, Gehad, additional, Elshafie, Maged, additional, Adly, Marwan H., additional, Elborai, Yasser, additional, Abdalla, Badr, additional, Taha, Hala, additional, Elkinaae, Naglaa, additional, Refaat, Amal, additional, Younis, Alaa, additional, and Alfaar, Ahmad S., additional

Published
2020
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47. Optimizing diagnostic imaging data using LI-RADS and the Likert scale in patients with hepatocellular carcinoma.

Author

Mor, Kholoud, Moustafa, Amr F., Refaat, Amal M., AbdEllatif, Ahmed, and ElAzab, Mohammed S.

Subjects
LIKERT scale, HEPATOCELLULAR carcinoma, DIAGNOSTIC imaging, COMPUTED tomography, DIAGNOSIS
Abstract

Purpose: The study aimed to compare the diagnostic performance of the Liver Imaging Reporting and Data System (LI-RADS), which incorporates fixed criteria, and the Likert scale (LS), which mainly depends on an overall impression in liver lesion diagnosis. Material and methods: Diagnostic data of 110 hepatic nodules in 103 high-risk patients for hepatocellular carcinoma (HCC) were included. Data including diameter, arterial hyperenhancement, washout, and capsule were reviewed by 2 readers using LI-RADS and LS (range, score 1-5). Inter-reader agreement (IRA), intraclass agreement (ICA), and diagnostic performance were determined by Fleiss, Cohen’s k, and logistic regression, respectively. Results: There were 53 triphasic enhanced computed tomography (CT) and 50 dynamic magnetic resonance (MR) examinations. Overall, IRA was excellent (k = 0.898). IRA was good for arterial hyperenhancement (k = 0.705), washout (k = 0.763), and capsule (k = 0.771) and excellent for diameter (k = 0.981) and tumour embolus (k = 0.927). Overall, ICA between LI-RADS and LS was fair 0.32; ICA was good for scores of 1 (k = 0.682), fair for scores of 2 (k = 0.36), moderate for scores of 5 (k = 0.52), but no agreement was found for scores of 3 (k = –0.059) and 4 (k = –0.022). LIRADS produced relatively high accuracy (87.3% vs. 80%), relatively low sensitivity (84.3% vs. 98%), and significantly higher specificity (89.83% vs. 64.4%) and positive likelihood ratio (+LR: 8.29 vs. 2.75) compared to LS approach. Conclusions: LI-RADS revealed higher diagnostic accuracy as compared to LS with statistical proof higher specificity and +LR showing its ability to foretell malignancy in high-risk patients. We recommend the practical application of the LI-RADS system in the detection and treatment response monitoring of patients with HCC. [ABSTRACT FROM AUTHOR]

Published
2021
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48. Patterns, risk factors and outcome predictors of posterior reversible encephalopathy syndrome in pediatric cancer patients.

Author

Hafez, Hanafy A., Ragab, Iman, Sedky, Mohamed, Shams, Marwa, Youssef, Ayda, Refaat, Amal, Habib, Elsaeed, and Sidhom, Iman

Subjects
POSTERIOR leukoencephalopathy syndrome, CHILD patients, SYNDROMES in children, CHILDHOOD cancer, CANCER patients, FRONTAL lobe diseases
Abstract

The purpose of this study was to assess the clinical and radiological patterns and outcome predictors of posterior reversible encephalopathy syndrome (PRES) in pediatric cancer patients. A retrospective study included patients who developed PRES during their treatment at the Children's Cancer Hospital Egypt. A total of 50 patients developed PRES. Leukemia and lymphoma were the commonest diagnoses (64%). Regarding the MRI findings, occipital affection was the most common (92%), followed by frontal and temporal lobes involvement in 32% and 22% respectively and advanced PRES was described in 8 patients. Of the whole patients, 80% had complete clinical resolution and 60% showed complete radiological resolution at 2 weeks' evaluation and 2 patients died out of PRES. Unfavorable outcome was associated with those who had motor dysfunction, status epilepticus at presentation, frontal lobe and thalamic affection and atypical PRES. PRES might present in atypical sites with poor outcome including death. [ABSTRACT FROM AUTHOR]

Published
2021
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50. Bilateral clear cell sarcoma of the kidney

Author

Zekri, Wael, primary, Yehia, Dina, additional, Elshafie, Maged M., additional, Zaghloul, Mohamed Saad, additional, El-Kinaai, Naglaa, additional, Taha, Hala, additional, Refaat, Amal, additional, Younes, Alaa A., additional, and Alfaar, Ahmad Samir, additional

Published
2015
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