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204 results on '"Rees‐Punia, Erika"'

1. Research Participants’ Perspectives on Using an Electronic Portal for Engagement and Data Collection: Focus Group Results From a Large Epidemiologic Cohort

Author

Rees-Punia, Erika, Patel, Alpa V, Beckwitt, Asher, Leach, Corinne R, Gapstur, Susan M, and Smith, Tenbroeck G

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract

BackgroundEpidemiologic cohort studies have begun to leverage electronic research participant portals to facilitate data collection, integrate wearable technologies, lower costs, and engage participants. However, little is known about the acceptability of portal use by research participants. ObjectiveThe aim of this study is to conduct focus groups among a sample of Cancer Prevention Study-3 (CPS-3) participants to better understand their preferences and concerns about research portals. MethodsCPS-3 participants were stratified based on sex, race and ethnicity, age, and cancer status, and randomly invited to participate. Focus groups used an exploratory case design with semistructured guides to prompt discussion. Using a constant comparison technique, transcripts were assigned codes to identify themes. ResultsParticipants (31/59, 52% women; 52/59, 88% White/non-Latinx) were favorably disposed toward using a research participant portal to take surveys, communicate with the study staff, and upload data. Most participants indicated that a portal would be beneficial and convenient but expressed concerns over data safety. Participants stressed the importance of an easy-to-use and trustworthy portal that is compatible with mobile devices. ConclusionsIn addition to being beneficial to researchers, portals may also benefit participants as long as the portals are secure and simple. Participants believe that portals can provide convenient ways to report data and remain connected to the study.

Published
2020
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2. A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry

Author

Middha, Pooja, Wang, Xiaoliang, Behrens, Sabine, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Michailidou, Kyriaki, Ahearn, Thomas U, Andrulis, Irene L, Anton-Culver, Hoda, Arndt, Volker, Aronson, Kristan J, Auer, Paul L, Augustinsson, Annelie, Baert, Thaïs, Freeman, Laura E Beane, Becher, Heiko, Beckmann, Matthias W, Benitez, Javier, Bojesen, Stig E, Brauch, Hiltrud, Brenner, Hermann, Brooks-Wilson, Angela, Campa, Daniele, Canzian, Federico, Carracedo, Angel, Castelao, Jose E, Chanock, Stephen J, Chenevix-Trench, Georgia, Cordina-Duverger, Emilie, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Dossus, Laure, Dugué, Pierre-Antoine, Eliassen, A Heather, Eriksson, Mikael, Evans, D Gareth, Fasching, Peter A, Figueroa, Jonine D, Fletcher, Olivia, Flyger, Henrik, Gabrielson, Marike, Gago-Dominguez, Manuela, Giles, Graham G, González-Neira, Anna, Grassmann, Felix, Grundy, Anne, Guénel, Pascal, Haiman, Christopher A, Håkansson, Niclas, Hall, Per, Hamann, Ute, Hankinson, Susan E, Harkness, Elaine F, Holleczek, Bernd, Hoppe, Reiner, Hopper, John L, Houlston, Richard S, Howell, Anthony, Hunter, David J, Ingvar, Christian, Isaksson, Karolin, Jernström, Helena, John, Esther M, Jones, Michael E, Kaaks, Rudolf, Keeman, Renske, Kitahara, Cari M, Ko, Yon-Dschun, Koutros, Stella, Kurian, Allison W, Lacey, James V, Lambrechts, Diether, Larson, Nicole L, Larsson, Susanna, Le Marchand, Loic, Lejbkowicz, Flavio, Li, Shuai, Linet, Martha, Lissowska, Jolanta, Martinez, Maria Elena, Maurer, Tabea, Mulligan, Anna Marie, Mulot, Claire, Murphy, Rachel A, Newman, William G, Nielsen, Sune F, Nordestgaard, Børge G, Norman, Aaron, O’Brien, Katie M, Olson, Janet E, Patel, Alpa V, Prentice, Ross, Rees-Punia, Erika, Rennert, Gad, Rhenius, Valerie, Ruddy, Kathryn J, and Sandler, Dale P

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer Genomics, Human Genome, Estrogen, Cancer, Women's Health, Genetics, Prevention, Aging, Breast Cancer, 2.1 Biological and endogenous factors, Adult, Female, Humans, Gene-Environment Interaction, Genetic Predisposition to Disease, Breast Neoplasms, Bayes Theorem, Genome-Wide Association Study, Risk Factors, Polymorphism, Single Nucleotide, Case-Control Studies, Breast cancer, Gene-environment interactions, Genetic epidemiology, European ancestry, CTS Consortium, ABCTB Investigators, kConFab Investigators, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundGenome-wide studies of gene-environment interactions (G×E) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures. We conducted a genome-wide G×E analysis of ~ 7.6 million common variants and seven lifestyle/environmental risk factors for breast cancer risk overall and for estrogen receptor positive (ER +) breast cancer.MethodsAnalyses were conducted using 72,285 breast cancer cases and 80,354 controls of European ancestry from the Breast Cancer Association Consortium. Gene-environment interactions were evaluated using standard unconditional logistic regression models and likelihood ratio tests for breast cancer risk overall and for ER + breast cancer. Bayesian False Discovery Probability was employed to assess the noteworthiness of each SNP-risk factor pairs.ResultsAssuming a 1 × 10-5 prior probability of a true association for each SNP-risk factor pairs and a Bayesian False Discovery Probability

Published
2023

7. Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts

Author

Paluch, Amanda E, Bajpai, Shivangi, Bassett, David R, Carnethon, Mercedes R, Ekelund, Ulf, Evenson, Kelly R, Galuska, Deborah A, Jefferis, Barbara J, Kraus, William E, Lee, I-Min, Matthews, Charles E, Omura, John D, Patel, Alpa V, Pieper, Carl F, Rees-Punia, Erika, Dallmeier, Dhayana, Klenk, Jochen, Whincup, Peter H, Dooley, Erin E, Pettee Gabriel, Kelley, Palta, Priya, Pompeii, Lisa A, Chernofsky, Ariel, Larson, Martin G, Vasan, Ramachandran S, Spartano, Nicole, Ballin, Marcel, Nordström, Peter, Nordström, Anna, Anderssen, Sigmund A, Hansen, Bjørge H, Cochrane, Jennifer A, Dwyer, Terence, Wang, Jing, Ferrucci, Luigi, Liu, Fangyu, Schrack, Jennifer, Urbanek, Jacek, Saint-Maurice, Pedro F, Yamamoto, Naofumi, Yoshitake, Yutaka, Newton, Robert L, Jr, Yang, Shengping, Shiroma, Eric J, and Fulton, Janet E

Published
2022
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12. Physical activity and pain in people with and without cancer.

Author

Swain, Christopher T. V., Masters, Matthew, Lynch, Brigid M., Patel, Alpa V., and Rees‐Punia, Erika

Subjects
PHYSICAL activity, CANCER pain, CANCER patients, METABOLIC equivalent, CANCER survivors, CANCER prevention
Abstract

Background: Performing physical activity may provide analgesic benefit, although this effect is more established for noncancer pain rather than cancer pain. The relationship between physical activity and pain outcomes in adults with and without a history of cancer was examined. Methods: Totals of 51,439 adults without a cancer history and 10,651 adults with a cancer history from the Cancer Prevention Study II Nutrition Cohort were included. Exposures included self‐reported moderate to vigorous physical activity (MVPA) as well as 2‐year change in MVPA. Pain outcomes included pain intensity (primary outcome) and analgesic use (secondary outcome). Results: MVPA was inversely associated with pain intensity for adults with (odds ratio [OR], 0.84 [≥15 metabolic equivalent of task (MET) h/week vs. <7.5 MET h/week]; 95% confidence interval [CI], 0.76–0.93) and without (OR, 0.79; 95% CI, 0.75–0.82) a history of cancer. Compared to remaining inactive, participants who became sufficiently active (cancer: OR, 0.76; 95% CI, 0.68–0.86; no cancer: OR, 0.73; 95% CI, 0.69–0.77), became inactive (cancer: OR, 0.79; 95% CI, 0.71–0.88; no cancer: OR, 0.84; 95% CI, 0.80–0.89), or remained sufficiently active (cancer: OR, 0.66; 95% CI, 0.60–0.72; no cancer: OR, 0.62; 95% CI, 0.60–0.65) also reported less pain. Physical activity was not related to analgesic use. Conclusions: The relationship between physical activity and pain intensity was not substantially different between people with and without a history of cancer. Cancer survivors who perform more activity, or who increase their activity, may experience less pain than cancer survivors who consistently perform less. Plain language summary: People who have had cancer often experience ongoing pain.Being physically active may help reduce the intensity of the pain they experience. This study examined physical activity and pain in people with and without a history of cancer. More physical activity was related to less pain in both groups. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Long‐term multimorbidity trajectories in older adults: The role of cancer, demographics, and health behaviors.

Author

Rees‐Punia, Erika, Masters, Matthew, Teras, Lauren R., Leach, Corinne R., Williams, Grant R., Newton, Christina C., Diver, W. Ryan, Patel, Alpa V., and Parsons, Helen M.

Subjects
*HEALTH behavior, *OLDER people, *CANCER patients, *COMORBIDITY, *CANCER survivors, *PREMATURE menopause
Abstract

Background: Multimorbidity is associated with premature mortality and excess health care costs. The burden of multimorbidity is highest among patients with cancer, yet trends and determinants of multimorbidity over time are poorly understood. Methods: Via Medicare claims linked to Cancer Prevention Study II data, group‐based trajectory modeling was used to compare National Cancer Institute comorbidity index score trends for cancer survivors and older adults without a cancer history. Among cancer survivors, multinomial logistic regression analyses evaluated associations between demographics, health behaviors, and comorbidity trajectories. Results: In 82,754 participants (mean age, 71.6 years [SD, 5.1 years]; 56.9% female), cancer survivors (n = 11,265) were more likely than older adults without a cancer history to experience the riskiest comorbidity trajectories: (1) steady, high comorbidity scores (remain high; odds ratio [OR], 1.36; 95% CI, 1.29–1.45), and (2) high scores that increased over time (start high and increase; OR, 1.51; 95% CI, 1.38–1.65). Cancer survivors who were physically active postdiagnosis were less likely to fall into these two trajectories (OR, 0.73; 95% CI, 0.64–0.84, remain high; OR, 0.42; 95% CI, 0.33–0.53, start high and increase) compared to inactive survivors. Cancer survivors with obesity were more likely to have a trajectory that started high and increased (OR, 2.83; 95% CI, 2.32–3.45 vs. normal weight), although being physically active offset some obesity‐related risk. Cancer survivors who smoked postdiagnosis were also six times more likely to have trajectories that started high and increased (OR, 6.86; 95% CI, 4.41–10.66 vs. never smokers). Conclusions: Older cancer survivors are more likely to have multiple comorbidities accumulated at a faster pace than older adults without a history of cancer. Weight management, physical activity, and smoking avoidance postdiagnosis may attenuate that trend. Older cancer survivors are more likely to have multiple comorbidities accumulated at a faster pace than older adults without a history of cancer. Weight management, physical activity, and smoking avoidance postdiagnosis may attenuate the trend. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Appendix 1 from Prospective Associations of Hemoglobin A1c and c-peptide with Risk of Diabetes-related Cancers in the Cancer Prevention Study-II Nutrition Cohort

Author

Campbell, Peter T., primary, Newton, Christina C., primary, Jacobs, Eric J., primary, McCullough, Marjorie L., primary, Wang, Ying, primary, Rees-Punia, Erika, primary, Guinter, Mark A., primary, Murphy, Neil, primary, Koshiol, Jill, primary, Dehal, Ahmed N., primary, Rohan, Thomas, primary, Strickler, Howard, primary, Petrick, Jessica, primary, Gunter, Marc, primary, Zhang, Xuehong, primary, McGlynn, Katherine A., primary, Pollak, Michael, primary, Patel, Alpa V., primary, and Gapstur, Susan M., primary

Published
2023
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24. Supplementary Tables S1-S4 from Prospective Associations of Hemoglobin A1c and c-peptide with Risk of Diabetes-related Cancers in the Cancer Prevention Study-II Nutrition Cohort

Author

Campbell, Peter T., primary, Newton, Christina C., primary, Jacobs, Eric J., primary, McCullough, Marjorie L., primary, Wang, Ying, primary, Rees-Punia, Erika, primary, Guinter, Mark A., primary, Murphy, Neil, primary, Koshiol, Jill, primary, Dehal, Ahmed N., primary, Rohan, Thomas, primary, Strickler, Howard, primary, Petrick, Jessica, primary, Gunter, Marc, primary, Zhang, Xuehong, primary, McGlynn, Katherine A., primary, Pollak, Michael, primary, Patel, Alpa V., primary, and Gapstur, Susan M., primary

Published
2023
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25. Data from Prospective Associations of Hemoglobin A1c and c-peptide with Risk of Diabetes-related Cancers in the Cancer Prevention Study-II Nutrition Cohort

Author

Campbell, Peter T., primary, Newton, Christina C., primary, Jacobs, Eric J., primary, McCullough, Marjorie L., primary, Wang, Ying, primary, Rees-Punia, Erika, primary, Guinter, Mark A., primary, Murphy, Neil, primary, Koshiol, Jill, primary, Dehal, Ahmed N., primary, Rohan, Thomas, primary, Strickler, Howard, primary, Petrick, Jessica, primary, Gunter, Marc, primary, Zhang, Xuehong, primary, McGlynn, Katherine A., primary, Pollak, Michael, primary, Patel, Alpa V., primary, and Gapstur, Susan M., primary

Published
2023
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27. A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry

Author

Middha, Pooja K., Wang, Xiaoliang, Behrens, Sabine, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Michailidou, Kyriaki, Ahearn, Thomas U., Andrulis, Irene L., Anton-Culver, Hoda, Arndt, Volker, Aronson, Kristan J., Auer, Paul L., Augustinsson, Annelie, Baert, Thais, Freeman, Laura E. Beane, Becher, Heiko, Beckmann, Matthias W., Benitez, Javier, Bojesen, Stig E., Brauch, Hiltrud, Brenner, Hermann, Brooks-Wilson, Angela, Campa, Daniele, Canzian, Federico, Carracedo, Angel, Castelao, Jose E., Chanock, Stephen J., Chenevix-Trench, Georgia, Cordina-Duverger, Emilie, Couch, Fergus J., Cox, Angela, Cross, Simon S., Czene, Kamila, Dossus, Laure, Dugue, Pierre-Antoine, Eliassen, A. Heather, Eriksson, Mikael, Evans, D. Gareth, Fasching, Peter A., Figueroa, Jonine, Fletcher, Olivia, Flyger, Henrik, Gabrielson, Marike, Gago-Dominguez, Manuela, Giles, Graham G., Gonzalez-Neira, Anna, Grassmann, Felix, Grundy, Anne, Guenel, Pascal, Haiman, Christopher A., Hakansson, Niclas, Hall, Per, Hamann, Ute, Hankinson, Susan E., Harkness, Elaine F., Holleczek, Bernd, Hoppe, Reiner, Hopper, John L., Houlston, Richard S., Howell, Anthony, Hunter, David J., Ingvar, Christian, Isaksson, Karolin, Jernstroem, Helena, John, Esther M., Jones, Michael E., Kaaks, Rudolf, Keeman, Renske, Kitahara, Cari M., Ko, Yon-Dschun, Koutros, Stella, Kurian, Allison W., Lacey, James V., Lambrechts, Diether, Larson, Nicole L., Larsson, Susanna C., Le Marchand, Loic, Lejbkowicz, Flavio, Li, Shuai, Linet, Martha, Lissowska, Jolanta, Martinez, Maria Elena, Maurer, Tabea, Mulligan, Anna Marie, Mulot, Claire, Murphy, Rachel A., Newman, William G., Nielsen, Sune F., Nordestgaard, Borge G., Norman, Aaron, O'Brien, Katie M., Olson, Janet E., Patel, Alpa V., Prentice, Ross, Rees-Punia, Erika, Rennert, Gad, Rhenius, Valerie, Ruddy, Kathryn J., Sandler, Dale P., Scott, Christopher G., Shah, Mitul T., Shu, Xiao-Ou, Smeets, Ann, Southey, Melissa C., Stone, Jennifer, Tamimi, Rulla M., Taylor, Jack A., Teras, Lauren R., Tomczyk, Katarzyna, Troester, Melissa A., Truong, Therese, Vachon, Celine M., Wang, Sophia S., Weinberg, Clarice R., Wildiers, Hans, Willett, Walter, Winham, Stacey J., Wolk, Alicja, Yang, Xiaohong, Zamora, M. Pilar, Zheng, Wei, Ziogas, Argyrios, Dunning, Alison M., Pharoah, Paul D. P., Garcia-Closas, Montserrat, Schmidt, Marjanka K., Kraft, Peter, Milne, Roger L., Lindstroem, Sara, Easton, Douglas F., Chang-Claude, Jenny, Middha, Pooja K., Wang, Xiaoliang, Behrens, Sabine, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Michailidou, Kyriaki, Ahearn, Thomas U., Andrulis, Irene L., Anton-Culver, Hoda, Arndt, Volker, Aronson, Kristan J., Auer, Paul L., Augustinsson, Annelie, Baert, Thais, Freeman, Laura E. Beane, Becher, Heiko, Beckmann, Matthias W., Benitez, Javier, Bojesen, Stig E., Brauch, Hiltrud, Brenner, Hermann, Brooks-Wilson, Angela, Campa, Daniele, Canzian, Federico, Carracedo, Angel, Castelao, Jose E., Chanock, Stephen J., Chenevix-Trench, Georgia, Cordina-Duverger, Emilie, Couch, Fergus J., Cox, Angela, Cross, Simon S., Czene, Kamila, Dossus, Laure, Dugue, Pierre-Antoine, Eliassen, A. Heather, Eriksson, Mikael, Evans, D. Gareth, Fasching, Peter A., Figueroa, Jonine, Fletcher, Olivia, Flyger, Henrik, Gabrielson, Marike, Gago-Dominguez, Manuela, Giles, Graham G., Gonzalez-Neira, Anna, Grassmann, Felix, Grundy, Anne, Guenel, Pascal, Haiman, Christopher A., Hakansson, Niclas, Hall, Per, Hamann, Ute, Hankinson, Susan E., Harkness, Elaine F., Holleczek, Bernd, Hoppe, Reiner, Hopper, John L., Houlston, Richard S., Howell, Anthony, Hunter, David J., Ingvar, Christian, Isaksson, Karolin, Jernstroem, Helena, John, Esther M., Jones, Michael E., Kaaks, Rudolf, Keeman, Renske, Kitahara, Cari M., Ko, Yon-Dschun, Koutros, Stella, Kurian, Allison W., Lacey, James V., Lambrechts, Diether, Larson, Nicole L., Larsson, Susanna C., Le Marchand, Loic, Lejbkowicz, Flavio, Li, Shuai, Linet, Martha, Lissowska, Jolanta, Martinez, Maria Elena, Maurer, Tabea, Mulligan, Anna Marie, Mulot, Claire, Murphy, Rachel A., Newman, William G., Nielsen, Sune F., Nordestgaard, Borge G., Norman, Aaron, O'Brien, Katie M., Olson, Janet E., Patel, Alpa V., Prentice, Ross, Rees-Punia, Erika, Rennert, Gad, Rhenius, Valerie, Ruddy, Kathryn J., Sandler, Dale P., Scott, Christopher G., Shah, Mitul T., Shu, Xiao-Ou, Smeets, Ann, Southey, Melissa C., Stone, Jennifer, Tamimi, Rulla M., Taylor, Jack A., Teras, Lauren R., Tomczyk, Katarzyna, Troester, Melissa A., Truong, Therese, Vachon, Celine M., Wang, Sophia S., Weinberg, Clarice R., Wildiers, Hans, Willett, Walter, Winham, Stacey J., Wolk, Alicja, Yang, Xiaohong, Zamora, M. Pilar, Zheng, Wei, Ziogas, Argyrios, Dunning, Alison M., Pharoah, Paul D. P., Garcia-Closas, Montserrat, Schmidt, Marjanka K., Kraft, Peter, Milne, Roger L., Lindstroem, Sara, Easton, Douglas F., and Chang-Claude, Jenny

Abstract

Background Genome-wide studies of gene-environment interactions (GxE) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures. We conducted a genome-wide GxE analysis of similar to 7.6 million common variants and seven lifestyle/environmental risk factors for breast cancer risk overall and for estrogen receptor positive (ER +) breast cancer. Methods Analyses were conducted using 72,285 breast cancer cases and 80,354 controls of European ancestry from the Breast Cancer Association Consortium. Gene-environment interactions were evaluated using standard unconditional logistic regression models and likelihood ratio tests for breast cancer risk overall and for ER + breast cancer. Bayesian False Discovery Probability was employed to assess the noteworthiness of each SNP-risk factor pairs. Results Assuming a 1 x 10(-5) prior probability of a true association for each SNP-risk factor pairs and a Bayesian False Discovery Probability < 15%, we identified two independent SNP-risk factor pairs: rs80018847(9p13)-LINGO2 and adult height in association with overall breast cancer risk (ORint = 0.94, 95% CI 0.92-0.96), and rs4770552(13q12)-SPATA13 and age at menarche for ER + breast cancer risk (ORint = 0.91, 95% CI 0.88-0.94). Conclusions Overall, the contribution of GxE interactions to the heritability of breast cancer is very small. At the population level, multiplicative GxE interactions do not make an important contribution to risk prediction in breast cancer.

Published
2023
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28. Prospective association of daily steps with cardiovascular disease : a harmonized meta-analysis

Author

Paluch, Amanda E., Bajpai, Shivangi, Ballin, Marcel, Bassett, David R., Buford, Thomas W., Carnethon, Mercedes R., Chernofsky, Ariel, Dooley, Erin E., Ekelund, Ulf, Evenson, Kelly R., Galuska, Deborah A., Jefferis, Barbara J., Kong, Lingsong, Kraus, William E., Larson, Martin G., Lee, I-Min, Matthews, Charles E., Newton, Robert L., Nordström, Anna, Nordström, Peter, Palta, Priya, Patel, Alpa V., Pettee Gabriel, Kelley, Pieper, Carl F., Pompeii, Lisa, Rees-Punia, Erika, Spartano, Nicole L., Vasan, Ramachandran S., Whincup, Peter H., Yang, Shengping, Fulton, Janet E., Paluch, Amanda E., Bajpai, Shivangi, Ballin, Marcel, Bassett, David R., Buford, Thomas W., Carnethon, Mercedes R., Chernofsky, Ariel, Dooley, Erin E., Ekelund, Ulf, Evenson, Kelly R., Galuska, Deborah A., Jefferis, Barbara J., Kong, Lingsong, Kraus, William E., Larson, Martin G., Lee, I-Min, Matthews, Charles E., Newton, Robert L., Nordström, Anna, Nordström, Peter, Palta, Priya, Patel, Alpa V., Pettee Gabriel, Kelley, Pieper, Carl F., Pompeii, Lisa, Rees-Punia, Erika, Spartano, Nicole L., Vasan, Ramachandran S., Whincup, Peter H., Yang, Shengping, and Fulton, Janet E.

Abstract

BACKGROUND: Taking fewer than the widely promoted "10 000 steps per day" has recently been associated with lower risk of all-cause mortality. The relationship of steps and cardiovascular disease (CVD) risk remains poorly described. A meta-analysis examining the dose-response relationship between steps per day and CVD can help inform clinical and public health guidelines. METHODS: Eight prospective studies (20 152 adults [ie, ≥18 years of age]) were included with device-measured steps and participants followed for CVD events. Studies quantified steps per day and CVD events were defined as fatal and nonfatal coronary heart disease, stroke, and heart failure. Cox proportional hazards regression analyses were completed using study-specific quartiles and hazard ratios (HR) and 95% CI were meta-analyzed with inverse-variance-weighted random effects models. RESULTS: The mean age of participants was 63.2±12.4 years and 52% were women. The mean follow-up was 6.2 years (123 209 person-years), with a total of 1523 CVD events (12.4 per 1000 participant-years) reported. There was a significant difference in the association of steps per day and CVD between older (ie, ≥60 years of age) and younger adults (ie, <60 years of age). For older adults, the HR for quartile 2 was 0.80 (95% CI, 0.69 to 0.93), 0.62 for quartile 3 (95% CI, 0.52 to 0.74), and 0.51 for quartile 4 (95% CI, 0.41 to 0.63) compared with the lowest quartile. For younger adults, the HR for quartile 2 was 0.79 (95% CI, 0.46 to 1.35), 0.90 for quartile 3 (95% CI, 0.64 to 1.25), and 0.95 for quartile 4 (95% CI, 0.61 to 1.48) compared with the lowest quartile. Restricted cubic splines demonstrated a nonlinear association whereby more steps were associated with decreased risk of CVD among older adults. CONCLUSIONS: For older adults, taking more daily steps was associated with a progressively decreased risk of CVD. Monitoring and promoting steps per day is a simple metric for clinician-patient communication and populati

Published
2023
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29. A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry.

Author

Arndt, Volker, Arndt, Volker, Aronson, Kristan, Auer, Paul, Augustinsson, Annelie, Baert, Thaïs, Freeman, Laura, Becher, Heiko, Beckmann, Matthias, Benitez, Javier, Bojesen, Stig, Brauch, Hiltrud, Brenner, Hermann, Brooks-Wilson, Angela, Campa, Daniele, Canzian, Federico, Carracedo, Angel, Castelao, Jose, Chanock, Stephen, Chenevix-Trench, Georgia, Cordina-Duverger, Emilie, Couch, Fergus, Cox, Angela, Cross, Simon, Czene, Kamila, Dossus, Laure, Dugué, Pierre-Antoine, Eliassen, A, Eriksson, Mikael, Evans, D, Fasching, Peter, Figueroa, Jonine, Fletcher, Olivia, Flyger, Henrik, Gabrielson, Marike, Gago-Dominguez, Manuela, Giles, Graham, González-Neira, Anna, Grassmann, Felix, Grundy, Anne, Guénel, Pascal, Haiman, Christopher, Håkansson, Niclas, Hall, Per, Hamann, Ute, Hankinson, Susan, Harkness, Elaine, Holleczek, Bernd, Hoppe, Reiner, Hopper, John, Houlston, Richard, Howell, Anthony, Hunter, David, Ingvar, Christian, Isaksson, Karolin, Jernström, Helena, John, Esther, Jones, Michael, Kaaks, Rudolf, Keeman, Renske, Kitahara, Cari, Ko, Yon-Dschun, Koutros, Stella, Kurian, Allison, Lacey, James, Lambrechts, Diether, Larson, Nicole, Larsson, Susanna, Le Marchand, Loic, Lejbkowicz, Flavio, Li, Shuai, Linet, Martha, Lissowska, Jolanta, Martinez, Maria, Maurer, Tabea, Mulligan, Anna, Mulot, Claire, Murphy, Rachel, Newman, William, Nielsen, Sune, Nordestgaard, Børge, Norman, Aaron, OBrien, Katie, Olson, Janet, Patel, Alpa, Prentice, Ross, Rees-Punia, Erika, Rennert, Gad, Rhenius, Valerie, Ruddy, Kathryn, Sandler, Dale, Scott, Christopher, Shah, Mitul, Shu, Xiao-Ou, Smeets, Ann, Southey, Melissa, Stone, Jennifer, Tamimi, Rulla, Taylor, Jack, Teras, Lauren, Tomczyk, Katarzyna, Arndt, Volker, Arndt, Volker, Aronson, Kristan, Auer, Paul, Augustinsson, Annelie, Baert, Thaïs, Freeman, Laura, Becher, Heiko, Beckmann, Matthias, Benitez, Javier, Bojesen, Stig, Brauch, Hiltrud, Brenner, Hermann, Brooks-Wilson, Angela, Campa, Daniele, Canzian, Federico, Carracedo, Angel, Castelao, Jose, Chanock, Stephen, Chenevix-Trench, Georgia, Cordina-Duverger, Emilie, Couch, Fergus, Cox, Angela, Cross, Simon, Czene, Kamila, Dossus, Laure, Dugué, Pierre-Antoine, Eliassen, A, Eriksson, Mikael, Evans, D, Fasching, Peter, Figueroa, Jonine, Fletcher, Olivia, Flyger, Henrik, Gabrielson, Marike, Gago-Dominguez, Manuela, Giles, Graham, González-Neira, Anna, Grassmann, Felix, Grundy, Anne, Guénel, Pascal, Haiman, Christopher, Håkansson, Niclas, Hall, Per, Hamann, Ute, Hankinson, Susan, Harkness, Elaine, Holleczek, Bernd, Hoppe, Reiner, Hopper, John, Houlston, Richard, Howell, Anthony, Hunter, David, Ingvar, Christian, Isaksson, Karolin, Jernström, Helena, John, Esther, Jones, Michael, Kaaks, Rudolf, Keeman, Renske, Kitahara, Cari, Ko, Yon-Dschun, Koutros, Stella, Kurian, Allison, Lacey, James, Lambrechts, Diether, Larson, Nicole, Larsson, Susanna, Le Marchand, Loic, Lejbkowicz, Flavio, Li, Shuai, Linet, Martha, Lissowska, Jolanta, Martinez, Maria, Maurer, Tabea, Mulligan, Anna, Mulot, Claire, Murphy, Rachel, Newman, William, Nielsen, Sune, Nordestgaard, Børge, Norman, Aaron, OBrien, Katie, Olson, Janet, Patel, Alpa, Prentice, Ross, Rees-Punia, Erika, Rennert, Gad, Rhenius, Valerie, Ruddy, Kathryn, Sandler, Dale, Scott, Christopher, Shah, Mitul, Shu, Xiao-Ou, Smeets, Ann, Southey, Melissa, Stone, Jennifer, Tamimi, Rulla, Taylor, Jack, Teras, Lauren, and Tomczyk, Katarzyna

Abstract

BACKGROUND: Genome-wide studies of gene-environment interactions (G×E) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures. We conducted a genome-wide G×E analysis of ~ 7.6 million common variants and seven lifestyle/environmental risk factors for breast cancer risk overall and for estrogen receptor positive (ER +) breast cancer. METHODS: Analyses were conducted using 72,285 breast cancer cases and 80,354 controls of European ancestry from the Breast Cancer Association Consortium. Gene-environment interactions were evaluated using standard unconditional logistic regression models and likelihood ratio tests for breast cancer risk overall and for ER + breast cancer. Bayesian False Discovery Probability was employed to assess the noteworthiness of each SNP-risk factor pairs. RESULTS: Assuming a 1 × 10-5 prior probability of a true association for each SNP-risk factor pairs and a Bayesian False Discovery Probability < 15%, we identified two independent SNP-risk factor pairs: rs80018847(9p13)-LINGO2 and adult height in association with overall breast cancer risk (ORint = 0.94, 95% CI 0.92-0.96), and rs4770552(13q12)-SPATA13 and age at menarche for ER + breast cancer risk (ORint = 0.91, 95% CI 0.88-0.94). CONCLUSIONS: Overall, the contribution of G×E interactions to the heritability of breast cancer is very small. At the population level, multiplicative G×E interactions do not make an important contribution to risk prediction in breast cancer.

Published
2023

35. Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study

Author

Dixon-Suen, Suzanne C, primary, Lewis, Sarah J, additional, Martin, Richard M, additional, English, Dallas R, additional, Boyle, Terry, additional, Giles, Graham G, additional, Michailidou, Kyriaki, additional, Bolla, Manjeet K, additional, Wang, Qin, additional, Dennis, Joe, additional, Lush, Michael, additional, Investigators, ABCTB, additional, Ahearn, Thomas U, additional, Ambrosone, Christine B, additional, Andrulis, Irene L, additional, Anton-Culver, Hoda, additional, Arndt, Volker, additional, Aronson, Kristan J, additional, Augustinsson, Annelie, additional, Auvinen, Päivi, additional, Beane Freeman, Laura E, additional, Becher, Heiko, additional, Beckmann, Matthias W, additional, Behrens, Sabine, additional, Bermisheva, Marina, additional, Blomqvist, Carl, additional, Bogdanova, Natalia V, additional, Bojesen, Stig E, additional, Bonanni, Bernardo, additional, Brenner, Hermann, additional, Brüning, Thomas, additional, Buys, Saundra S, additional, Camp, Nicola J, additional, Campa, Daniele, additional, Canzian, Federico, additional, Castelao, Jose E, additional, Cessna, Melissa H, additional, Chang-Claude, Jenny, additional, Chanock, Stephen J, additional, Clarke, Christine L, additional, Conroy, Don M, additional, Couch, Fergus J, additional, Cox, Angela, additional, Cross, Simon S, additional, Czene, Kamila, additional, Daly, Mary B, additional, Devilee, Peter, additional, Dörk, Thilo, additional, Dwek, Miriam, additional, Eccles, Diana M, additional, Eliassen, A. Heather, additional, Engel, Christoph, additional, Eriksson, Mikael, additional, Evans, D. Gareth, additional, Fasching, Peter A, additional, Fletcher, Olivia, additional, Flyger, Henrik, additional, Fritschi, Lin, additional, Gabrielson, Marike, additional, Gago-Dominguez, Manuela, additional, García-Closas, Montserrat, additional, García-Sáenz, José A, additional, Goldberg, Mark S, additional, Guénel, Pascal, additional, Gündert, Melanie, additional, Hahnen, Eric, additional, Haiman, Christopher A, additional, Häberle, Lothar, additional, Håkansson, Niclas, additional, Hall, Per, additional, Hamann, Ute, additional, Hart, Steven N, additional, Harvie, Michelle, additional, Hillemanns, Peter, additional, Hollestelle, Antoinette, additional, Hooning, Maartje J, additional, Hoppe, Reiner, additional, Hopper, John, additional, Howell, Anthony, additional, Hunter, David J, additional, Jakubowska, Anna, additional, Janni, Wolfgang, additional, John, Esther M, additional, Jung, Audrey, additional, Kaaks, Rudolf, additional, Keeman, Renske, additional, Kitahara, Cari M, additional, Koutros, Stella, additional, Kraft, Peter, additional, Kristensen, Vessela N, additional, Kubelka-Sabit, Katerina, additional, Kurian, Allison W, additional, Lacey, James V, additional, Lambrechts, Diether, additional, Le Marchand, Loic, additional, Lindblom, Annika, additional, Loibl, Sibylle, additional, Lubiński, Jan, additional, Mannermaa, Arto, additional, Manoochehri, Mehdi, additional, Margolin, Sara, additional, Martinez, Maria Elena, additional, Mavroudis, Dimitrios, additional, Menon, Usha, additional, Mulligan, Anna Marie, additional, Murphy, Rachel A, additional, Collaborators, NBCS, additional, Nevanlinna, Heli, additional, Nevelsteen, Ines, additional, Newman, William G, additional, Offit, Kenneth, additional, Olshan, Andrew F, additional, Olsson, Håkan, additional, Orr, Nick, additional, Patel, Alpa, additional, Peto, Julian, additional, Plaseska-Karanfilska, Dijana, additional, Presneau, Nadege, additional, Rack, Brigitte, additional, Radice, Paolo, additional, Rees-Punia, Erika, additional, Rennert, Gad, additional, Rennert, Hedy S, additional, Romero, Atocha, additional, Saloustros, Emmanouil, additional, Sandler, Dale P, additional, Schmidt, Marjanka K, additional, Schmutzler, Rita K, additional, Schwentner, Lukas, additional, Scott, Christopher, additional, Shah, Mitul, additional, Shu, Xiao-Ou, additional, Simard, Jacques, additional, Southey, Melissa C, additional, Stone, Jennifer, additional, Surowy, Harald, additional, Swerdlow, Anthony J, additional, Tamimi, Rulla M, additional, Tapper, William J, additional, Taylor, Jack A, additional, Terry, Mary Beth, additional, Tollenaar, Rob A E M, additional, Troester, Melissa A, additional, Truong, Thérèse, additional, Untch, Michael, additional, Vachon, Celine M, additional, Joseph, Vijai, additional, Wappenschmidt, Barbara, additional, Weinberg, Clarice R, additional, Wolk, Alicja, additional, Yannoukakos, Drakoulis, additional, Zheng, Wei, additional, Ziogas, Argyrios, additional, Dunning, Alison M, additional, Pharoah, Paul D P, additional, Easton, Douglas F, additional, Milne, Roger L, additional, and Lynch, Brigid M, additional

Published
2022
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39. Prospective Associations of Hemoglobin A1c and c-peptide with Risk of Diabetes-related Cancers in the Cancer Prevention Study-II Nutrition Cohort

Author

Campbell, Peter T., primary, Newton, Christina C., additional, Jacobs, Eric J., additional, McCullough, Marjorie L., additional, Wang, Ying, additional, Rees-Punia, Erika, additional, Guinter, Mark A., additional, Murphy, Neil, additional, Koshiol, Jill, additional, Dehal, Ahmed N., additional, Rohan, Thomas, additional, Strickler, Howard, additional, Petrick, Jessica, additional, Gunter, Marc, additional, Zhang, Xuehong, additional, McGlynn, Katherine A., additional, Pollak, Michael, additional, Patel, Alpa V., additional, and Gapstur, Susan M., additional

Published
2022
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41. Daily steps and all-cause mortality : a meta-analysis of 15 international cohorts

Author

Paluch, Amanda E., Bajpai, Shivangi, Bassett, David R., Carnethon, Mercedes R., Ekelund, Ulf, Evenson, Kelly R., Galuska, Deborah A., Jefferis, Barbara J., Kraus, William E., Lee, I-Min, Matthews, Charles E., Omura, John D., Patel, Alpa V., Pieper, Carl F., Rees-Punia, Erika, Dallmeier, Dhayana, Klenk, Jochen, Whincup, Peter H., Dooley, Erin E., Pettee Gabriel, Kelley, Palta, Priya, Pompeii, Lisa A., Chernofsky, Ariel, Larson, Martin G., Vasan, Ramachandran S., Spartano, Nicole, Ballin, Marcel, Nordström, Peter, Nordström, Anna, Anderssen, Sigmund A., Hansen, Bjørge H., Cochrane, Jennifer A., Dwyer, Terence, Wang, Jing, Ferrucci, Luigi, Liu, Fangyu, Schrack, Jennifer, Urbanek, Jacek, Saint-Maurice, Pedro F., Yamamoto, Naofumi, Yoshitake, Yutaka, Newton, Robert L., Yang, Shengping, Shiroma, Eric J., Fulton, Janet E., Paluch, Amanda E., Bajpai, Shivangi, Bassett, David R., Carnethon, Mercedes R., Ekelund, Ulf, Evenson, Kelly R., Galuska, Deborah A., Jefferis, Barbara J., Kraus, William E., Lee, I-Min, Matthews, Charles E., Omura, John D., Patel, Alpa V., Pieper, Carl F., Rees-Punia, Erika, Dallmeier, Dhayana, Klenk, Jochen, Whincup, Peter H., Dooley, Erin E., Pettee Gabriel, Kelley, Palta, Priya, Pompeii, Lisa A., Chernofsky, Ariel, Larson, Martin G., Vasan, Ramachandran S., Spartano, Nicole, Ballin, Marcel, Nordström, Peter, Nordström, Anna, Anderssen, Sigmund A., Hansen, Bjørge H., Cochrane, Jennifer A., Dwyer, Terence, Wang, Jing, Ferrucci, Luigi, Liu, Fangyu, Schrack, Jennifer, Urbanek, Jacek, Saint-Maurice, Pedro F., Yamamoto, Naofumi, Yoshitake, Yutaka, Newton, Robert L., Yang, Shengping, Shiroma, Eric J., and Fulton, Janet E.

Abstract

BACKGROUND: Although 10 000 steps per day is widely promoted to have health benefits, there is little evidence to support this recommendation. We aimed to determine the association between number of steps per day and stepping rate with all-cause mortality. METHODS: In this meta-analysis, we identified studies investigating the effect of daily step count on all-cause mortality in adults (aged ≥18 years), via a previously published systematic review and expert knowledge of the field. We asked participating study investigators to process their participant-level data following a standardised protocol. The primary outcome was all-cause mortality collected from death certificates and country registries. We analysed the dose-response association of steps per day and stepping rate with all-cause mortality. We did Cox proportional hazards regression analyses using study-specific quartiles of steps per day and calculated hazard ratios (HRs) with inverse-variance weighted random effects models. FINDINGS: We identified 15 studies, of which seven were published and eight were unpublished, with study start dates between 1999 and 2018. The total sample included 47 471 adults, among whom there were 3013 deaths (10·1 per 1000 participant-years) over a median follow-up of 7·1 years ([IQR 4·3-9·9]; total sum of follow-up across studies was 297 837 person-years). Quartile median steps per day were 3553 for quartile 1, 5801 for quartile 2, 7842 for quartile 3, and 10 901 for quartile 4. Compared with the lowest quartile, the adjusted HR for all-cause mortality was 0·60 (95% CI 0·51-0·71) for quartile 2, 0·55 (0·49-0·62) for quartile 3, and 0·47 (0·39-0·57) for quartile 4. Restricted cubic splines showed progressively decreasing risk of mortality among adults aged 60 years and older with increasing number of steps per day until 6000-8000 steps per day and among adults younger than 60 years until 8000-10 000 steps per day. Adjusting for number of steps per day, comparing quartile 1 with q

Published
2022
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42. Physical activity, sedentary time and breast cancer risk : a Mendelian randomisation study

Author

Dixon-Suen, Suzanne C, Lewis, Sarah J, Martin, Richard M, English, Dallas R, Boyle, Terry, Giles, Graham G, Michailidou, Kyriaki, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Lush, Michael, Investigators, Abctb, Ahearn, Thomas U, Ambrosone, Christine B, Andrulis, Irene L, Anton-Culver, Hoda, Arndt, Volker, Aronson, Kristan J, Augustinsson, Annelie, Auvinen, Päivi, Beane Freeman, Laura E, Becher, Heiko, Beckmann, Matthias W, Behrens, Sabine, Bermisheva, Marina, Blomqvist, Carl, Bogdanova, Natalia V, Bojesen, Stig E, Bonanni, Bernardo, Brenner, Hermann, Brüning, Thomas, Buys, Saundra S, Camp, Nicola J, Campa, Daniele, Canzian, Federico, Castelao, Jose E, Cessna, Melissa H, Chang-Claude, Jenny, Chanock, Stephen J, Clarke, Christine L, Conroy, Don M, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Daly, Mary B, Devilee, Peter, Dörk, Thilo, Dwek, Miriam, Eccles, Diana M, Eliassen, A Heather, Engel, Christoph, Eriksson, Mikael, Evans, D Gareth, Fasching, Peter A, Fletcher, Olivia, Flyger, Henrik, Fritschi, Lin, Gabrielson, Marike, Gago-Dominguez, Manuela, García-Closas, Montserrat, García-Sáenz, José A, Goldberg, Mark S, Guénel, Pascal, Gündert, Melanie, Hahnen, Eric, Haiman, Christopher A, Häberle, Lothar, Håkansson, Niclas, Hall, Per, Hamann, Ute, Hart, Steven N, Harvie, Michelle, Hillemanns, Peter, Hollestelle, Antoinette, Hooning, Maartje J, Hoppe, Reiner, Hopper, John, Howell, Anthony, Hunter, David J, Jakubowska, Anna, Janni, Wolfgang, John, Esther M, Jung, Audrey, Kaaks, Rudolf, Keeman, Renske, Kitahara, Cari M, Koutros, Stella, Kraft, Peter, Kristensen, Vessela N, Kubelka-Sabit, Katerina, Kurian, Allison W, Lacey, James V, Lambrechts, Diether, Le Marchand, Loic, Lindblom, Annika, Loibl, Sibylle, Lubiński, Jan, Mannermaa, Arto, Manoochehri, Mehdi, Margolin, Sara, Martinez, Maria Elena, Mavroudis, Dimitrios, Menon, Usha, Mulligan, Anna Marie, Murphy, Rachel A, Collaborators, Nbcs, Nevanlinna, Heli, Nevelsteen, Ines, Newman, William G, Offit, Kenneth, Olshan, Andrew F, Olsson, Håkan, Orr, Nick, Patel, Alpa, Peto, Julian, Plaseska-Karanfilska, Dijana, Presneau, Nadege, Rack, Brigitte, Radice, Paolo, Rees-Punia, Erika, Rennert, Gad, Rennert, Hedy S, Romero, Atocha, Saloustros, Emmanouil, Sandler, Dale P, Schmidt, Marjanka K, Schmutzler, Rita K, Schwentner, Lukas, Scott, Christopher, Shah, Mitul, Shu, Xiao-Ou, Simard, Jacques, Southey, Melissa C, Stone, Jennifer, Surowy, Harald, Swerdlow, Anthony J, Tamimi, Rulla M, Tapper, William J, Taylor, Jack A, Terry, Mary Beth, Tollenaar, Rob A E M, Troester, Melissa A, Truong, Thérèse, Untch, Michael, Vachon, Celine M, Joseph, Vijai, Wappenschmidt, Barbara, Weinberg, Clarice R, Wolk, Alicja, Yannoukakos, Drakoulis, Zheng, Wei, Ziogas, Argyrios, Dunning, Alison M, Pharoah, Paul D P, Easton, Douglas F, Milne, Roger L, Lynch, Brigid M, Dixon-Suen, Suzanne C, Lewis, Sarah J, Martin, Richard M, English, Dallas R, Boyle, Terry, Giles, Graham G, Michailidou, Kyriaki, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Lush, Michael, Investigators, Abctb, Ahearn, Thomas U, Ambrosone, Christine B, Andrulis, Irene L, Anton-Culver, Hoda, Arndt, Volker, Aronson, Kristan J, Augustinsson, Annelie, Auvinen, Päivi, Beane Freeman, Laura E, Becher, Heiko, Beckmann, Matthias W, Behrens, Sabine, Bermisheva, Marina, Blomqvist, Carl, Bogdanova, Natalia V, Bojesen, Stig E, Bonanni, Bernardo, Brenner, Hermann, Brüning, Thomas, Buys, Saundra S, Camp, Nicola J, Campa, Daniele, Canzian, Federico, Castelao, Jose E, Cessna, Melissa H, Chang-Claude, Jenny, Chanock, Stephen J, Clarke, Christine L, Conroy, Don M, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Daly, Mary B, Devilee, Peter, Dörk, Thilo, Dwek, Miriam, Eccles, Diana M, Eliassen, A Heather, Engel, Christoph, Eriksson, Mikael, Evans, D Gareth, Fasching, Peter A, Fletcher, Olivia, Flyger, Henrik, Fritschi, Lin, Gabrielson, Marike, Gago-Dominguez, Manuela, García-Closas, Montserrat, García-Sáenz, José A, Goldberg, Mark S, Guénel, Pascal, Gündert, Melanie, Hahnen, Eric, Haiman, Christopher A, Häberle, Lothar, Håkansson, Niclas, Hall, Per, Hamann, Ute, Hart, Steven N, Harvie, Michelle, Hillemanns, Peter, Hollestelle, Antoinette, Hooning, Maartje J, Hoppe, Reiner, Hopper, John, Howell, Anthony, Hunter, David J, Jakubowska, Anna, Janni, Wolfgang, John, Esther M, Jung, Audrey, Kaaks, Rudolf, Keeman, Renske, Kitahara, Cari M, Koutros, Stella, Kraft, Peter, Kristensen, Vessela N, Kubelka-Sabit, Katerina, Kurian, Allison W, Lacey, James V, Lambrechts, Diether, Le Marchand, Loic, Lindblom, Annika, Loibl, Sibylle, Lubiński, Jan, Mannermaa, Arto, Manoochehri, Mehdi, Margolin, Sara, Martinez, Maria Elena, Mavroudis, Dimitrios, Menon, Usha, Mulligan, Anna Marie, Murphy, Rachel A, Collaborators, Nbcs, Nevanlinna, Heli, Nevelsteen, Ines, Newman, William G, Offit, Kenneth, Olshan, Andrew F, Olsson, Håkan, Orr, Nick, Patel, Alpa, Peto, Julian, Plaseska-Karanfilska, Dijana, Presneau, Nadege, Rack, Brigitte, Radice, Paolo, Rees-Punia, Erika, Rennert, Gad, Rennert, Hedy S, Romero, Atocha, Saloustros, Emmanouil, Sandler, Dale P, Schmidt, Marjanka K, Schmutzler, Rita K, Schwentner, Lukas, Scott, Christopher, Shah, Mitul, Shu, Xiao-Ou, Simard, Jacques, Southey, Melissa C, Stone, Jennifer, Surowy, Harald, Swerdlow, Anthony J, Tamimi, Rulla M, Tapper, William J, Taylor, Jack A, Terry, Mary Beth, Tollenaar, Rob A E M, Troester, Melissa A, Truong, Thérèse, Untch, Michael, Vachon, Celine M, Joseph, Vijai, Wappenschmidt, Barbara, Weinberg, Clarice R, Wolk, Alicja, Yannoukakos, Drakoulis, Zheng, Wei, Ziogas, Argyrios, Dunning, Alison M, Pharoah, Paul D P, Easton, Douglas F, Milne, Roger L, and Lynch, Brigid M

Abstract

OBJECTIVES: Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast cancer risk overall, pre/post-menopause, and by case-groups defined by tumour characteristics. METHODS: We performed two-sample inverse-variance-weighted MR using individual-level Breast Cancer Association Consortium case-control data from 130 957 European-ancestry women (69 838 invasive cases), and published UK Biobank data (n=91 105-377 234). Genetic instruments were single nucleotide polymorphisms (SNPs) associated in UK Biobank with wrist-worn accelerometer-measured overall physical activity (nsnps=5) or sedentary time (nsnps=6), or accelerometer-measured (nsnps=1) or self-reported (nsnps=5) vigorous physical activity. RESULTS: Greater genetically-predicted overall activity was associated with lower breast cancer overall risk (OR=0.59; 95% confidence interval (CI) 0.42 to 0.83 per-standard deviation (SD;~8 milligravities acceleration)) and for most case-groups. Genetically-predicted vigorous activity was associated with lower risk of pre/perimenopausal breast cancer (OR=0.62; 95% CI 0.45 to 0.87,≥3 vs. 0 self-reported days/week), with consistent estimates for most case-groups. Greater genetically-predicted sedentary time was associated with higher hormone-receptor-negative tumour risk (OR=1.77; 95% CI 1.07 to 2.92 per-SD (~7% time spent sedentary)), with elevated estimates for most case-groups. Results were robust to sensitivity analyses examining pleiotropy (including weighted-median-MR, MR-Egger). CONCLUSION: Our study provides strong evidence that greater overall physical activity, greater vigorous activity, and lower sedentary time are likely to reduce breast cancer r

Published
2022
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43. Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study

Author

Dixon-Suen, Suzanne C., Lewis, Sarah J., Martin, Richard M., English, Dallas R., Boyle, Terry, Giles, Graham G., Michailidou, Kyriaki, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Lush, Michael, Ahearn, Thomas U., Ambrosone, Christine B., Andrulis, Irene L., Anton-Culver, Hoda, Arndt, Volker, Aronson, Kristan J., Augustinsson, Annelie, Auvinen, Paivi, Beane Freeman, Laura E., Becher, Heiko, Beckmann, Matthias W., Behrens, Sabine, Bermisheva, Marina, Blomqvist, Carl, Bogdanova, Natalia, V, Bojesen, Stig E., Bonanni, Bernardo, Brenner, Hermann, Bruening, Thomas, Buys, Saundra S., Camp, Nicola J., Campa, Daniele, Canzian, Federico, Castelao, Jose E., Cessna, Melissa H., Chang-Claude, Jenny, Chanock, Stephen J., Clarke, Christine L., Conroy, Don M., Couch, Fergus J., Cox, Angela, Cross, Simon S., Czene, Kamila, Daly, Mary B., Devilee, Peter, Doerk, Thilo, Dwek, Miriam, Eccles, Diana M., Eliassen, A. Heather, Engel, Christoph, Eriksson, Mikael, Evans, D. Gareth, Fasching, Peter A., Fletcher, Olivia, Flyger, Henrik, Fritschi, Lin, Gabrielson, Marike, Gago-Dominguez, Manuela, Garcia-Closas, Montserrat, Garcia-Saenz, Jose A., Goldberg, Mark S., Guenel, Pascal, Guendert, Melanie, Hahnen, Eric, Haiman, Christopher A., Haeberle, Lothar, Hakansson, Niclas, Hall, Per, Hamann, Ute, Hart, Steven N., Harvie, Michelle, Hillemanns, Peter, Hollestelle, Antoinette, Hooning, Maartje J., Hoppe, Reiner, Hopper, John, Howell, Anthony, Hunter, David J., Jakubowska, Anna, Janni, Wolfgang, John, Esther M., Jung, Audrey, Kaaks, Rudolf, Keeman, Renske, Kitahara, Cari M., Koutros, Stella, Kraft, Peter, Kristensen, Vessela N., Kubelka-Sabit, Katerina, Kurian, Allison W., Lacey, James, V, Lambrechts, Diether, Le Marchand, Loic, Lindblom, Annika, Loibl, Sibylle, Lubinski, Jan, Mannermaa, Arto, Manoochehri, Mehdi, Margolin, Sara, Martinez, Maria Elena, Mavroudis, Dimitrios, Menon, Usha, Mulligan, Anna Marie, Murphy, Rachel A., Nevanlinna, Heli, Nevelsteen, Ines, Newman, William G., Offit, Kenneth, Olshan, Andrew F., Olsson, Hakan, Orr, Nick, Patel, Alpa, Peto, Julian, Plaseska-Karanfilska, Dijana, Presneau, Nadege, Rack, Brigitte, Radice, Paolo, Rees-Punia, Erika, Rennert, Gad, Rennert, Hedy S., Romero, Atocha, Saloustros, Emmanouil, Sandler, Dale P., Schmidt, Marjanka K., Schmutzler, Rita K., Schwentner, Lukas, Scott, Christopher, Shah, Mitul, Shu, Xiao-Ou, Simard, Jacques, Southey, Melissa C., Stone, Jennifer, Surowy, Harald, Swerdlow, Anthony J., Tamimi, Rulla M., Tapper, William J., Taylor, Jack A., Terry, Mary Beth, Tollenaar, Rob A. E. M., Troester, Melissa A., Truong, Therese, Untch, Michael, Vachon, Celine M., Joseph, Vijai, Wappenschmidt, Barbara, Weinberg, Clarice R., Wolk, Alicja, Yannoukakos, Drakoulis, Zheng, Wei, Ziogas, Argyrios, Dunning, Alison M., Pharoah, Paul D. P., Easton, Douglas F., Milne, Roger L., Lynch, Brigid M., Dixon-Suen, Suzanne C., Lewis, Sarah J., Martin, Richard M., English, Dallas R., Boyle, Terry, Giles, Graham G., Michailidou, Kyriaki, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Lush, Michael, Ahearn, Thomas U., Ambrosone, Christine B., Andrulis, Irene L., Anton-Culver, Hoda, Arndt, Volker, Aronson, Kristan J., Augustinsson, Annelie, Auvinen, Paivi, Beane Freeman, Laura E., Becher, Heiko, Beckmann, Matthias W., Behrens, Sabine, Bermisheva, Marina, Blomqvist, Carl, Bogdanova, Natalia, V, Bojesen, Stig E., Bonanni, Bernardo, Brenner, Hermann, Bruening, Thomas, Buys, Saundra S., Camp, Nicola J., Campa, Daniele, Canzian, Federico, Castelao, Jose E., Cessna, Melissa H., Chang-Claude, Jenny, Chanock, Stephen J., Clarke, Christine L., Conroy, Don M., Couch, Fergus J., Cox, Angela, Cross, Simon S., Czene, Kamila, Daly, Mary B., Devilee, Peter, Doerk, Thilo, Dwek, Miriam, Eccles, Diana M., Eliassen, A. Heather, Engel, Christoph, Eriksson, Mikael, Evans, D. Gareth, Fasching, Peter A., Fletcher, Olivia, Flyger, Henrik, Fritschi, Lin, Gabrielson, Marike, Gago-Dominguez, Manuela, Garcia-Closas, Montserrat, Garcia-Saenz, Jose A., Goldberg, Mark S., Guenel, Pascal, Guendert, Melanie, Hahnen, Eric, Haiman, Christopher A., Haeberle, Lothar, Hakansson, Niclas, Hall, Per, Hamann, Ute, Hart, Steven N., Harvie, Michelle, Hillemanns, Peter, Hollestelle, Antoinette, Hooning, Maartje J., Hoppe, Reiner, Hopper, John, Howell, Anthony, Hunter, David J., Jakubowska, Anna, Janni, Wolfgang, John, Esther M., Jung, Audrey, Kaaks, Rudolf, Keeman, Renske, Kitahara, Cari M., Koutros, Stella, Kraft, Peter, Kristensen, Vessela N., Kubelka-Sabit, Katerina, Kurian, Allison W., Lacey, James, V, Lambrechts, Diether, Le Marchand, Loic, Lindblom, Annika, Loibl, Sibylle, Lubinski, Jan, Mannermaa, Arto, Manoochehri, Mehdi, Margolin, Sara, Martinez, Maria Elena, Mavroudis, Dimitrios, Menon, Usha, Mulligan, Anna Marie, Murphy, Rachel A., Nevanlinna, Heli, Nevelsteen, Ines, Newman, William G., Offit, Kenneth, Olshan, Andrew F., Olsson, Hakan, Orr, Nick, Patel, Alpa, Peto, Julian, Plaseska-Karanfilska, Dijana, Presneau, Nadege, Rack, Brigitte, Radice, Paolo, Rees-Punia, Erika, Rennert, Gad, Rennert, Hedy S., Romero, Atocha, Saloustros, Emmanouil, Sandler, Dale P., Schmidt, Marjanka K., Schmutzler, Rita K., Schwentner, Lukas, Scott, Christopher, Shah, Mitul, Shu, Xiao-Ou, Simard, Jacques, Southey, Melissa C., Stone, Jennifer, Surowy, Harald, Swerdlow, Anthony J., Tamimi, Rulla M., Tapper, William J., Taylor, Jack A., Terry, Mary Beth, Tollenaar, Rob A. E. M., Troester, Melissa A., Truong, Therese, Untch, Michael, Vachon, Celine M., Joseph, Vijai, Wappenschmidt, Barbara, Weinberg, Clarice R., Wolk, Alicja, Yannoukakos, Drakoulis, Zheng, Wei, Ziogas, Argyrios, Dunning, Alison M., Pharoah, Paul D. P., Easton, Douglas F., Milne, Roger L., and Lynch, Brigid M.

Abstract

Objectives Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast cancer risk overall, pre/post-menopause, and by case-groups defined by tumour characteristics. Methods We performed two-sample inverse-variance-weighted MR using individual-level Breast Cancer Association Consortium case-control data from 130 957 European-ancestry women (69 838 invasive cases), and published UK Biobank data (n=91 105-377 234). Genetic instruments were single nucleotide polymorphisms (SNPs) associated in UK Biobank with wrist-worn accelerometer-measured overall physical activity (n(snps)=5) or sedentary time (n(snps)=6), or accelerometer-measured (n(snps)=1) or self-reported (n(snps)=5) vigorous physical activity. Results Greater genetically-predicted overall activity was associated with lower breast cancer overall risk (OR=0.59; 95% confidence interval (CI) 0.42 to 0.83 per-standard deviation (SD;similar to 8 milligravities acceleration)) and for most case-groups. Genetically-predicted vigorous activity was associated with lower risk of pre/perimenopausal breast cancer (OR=0.62; 95% CI 0.45 to 0.87,>= 3 vs. 0 self-reported days/week), with consistent estimates for most case-groups. Greater genetically-predicted sedentary time was associated with higher hormone-receptor-negative tumour risk (OR=1.77; 95% CI 1.07 to 2.92 per-SD (similar to 7% time spent sedentary)), with elevated estimates for most case-groups. Results were robust to sensitivity analyses examining pleiotropy (including weighted-median-MR, MR-Egger). Conclusion Our study provides strong evidence that greater overall physical activity, greater vigorous activity, and lower sedentary time are likely

Published
2022

44. Physical activity, sedentary time and breast cancer risk:a Mendelian randomisation study

Author

Dixon-Suen, Suzanne C., Lewis, Sarah J., Martin, Richard M., English, Dallas R., Boyle, Terry, Giles, Graham G., Michailidou, Kyriaki, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Lush, Michael, Ahearn, Thomas U., Ambrosone, Christine B., Andrulis, Irene L., Anton-Culver, Hoda, Arndt, Volker, Aronson, Kristan J., Augustinsson, Annelie, Auvinen, Päivi, Freeman, Laura E.Beane, Becher, Heiko, Beckmann, Matthias W., Behrens, Sabine, Bermisheva, Marina, Blomqvist, Carl, Bogdanova, Natalia V., Bojesen, Stig E., Bonanni, Bernardo, Brenner, Hermann, Brüning, Thomas, Buys, Saundra S., Camp, Nicola J., Campa, Daniele, Canzian, Federico, Castelao, Jose E., Cessna, Melissa H., Chang-Claude, Jenny, Chanock, Stephen J., Clarke, Christine L., Conroy, Don M., Couch, Fergus J., Cox, Angela, Cross, Simon S., Czene, Kamila, Daly, Mary B., Devilee, Peter, Dörk, Thilo, Dwek, Miriam, Eccles, Diana M., Eliassen, A. Heather, Engel, Christoph, Eriksson, Mikael, Evans, D. Gareth, Fasching, Peter A., Fletcher, Olivia, Flyger, Henrik, Fritschi, Lin, Gabrielson, Marike, Gago-Dominguez, Manuela, García-Closas, Montserrat, Goldberg, Mark S., Guénel, Pascal, Gündert, Melanie, Hahnen, Eric, Haiman, Christopher A., Häberle, Lothar, Håkansson, Niclas, Hall, Per, Hamann, Ute, Hart, Steven N., Harvie, Michelle, Hillemanns, Peter, Hollestelle, Antoinette, Hooning, Maartje J., Hoppe, Reiner, Hopper, John L., Howell, Anthony, Hunter, David J., Jakubowska, Anna, Janni, Wolfgang, John, Esther M., Jung, Audrey Y., Kaaks, Rudolf, Keeman, Renske, Kitahara, Cari M., Koutros, Stella, Kraft, Peter, Kristensen, Vessela N., Kubelka-Sabit, Katerina, Kurian, Allison W., Lacey, James V., Lambrechts, Diether, Marchand, Loic Le, Lindblom, Annika, Loibl, Sibylle, Lubiński, Jan, Mannermaa, Arto, Manoochehri, Mehdi, Margolin, Sara, Martinez, Maria Elena, Mavroudis, Dimitrios, Menon, Usha, Mulligan, Anna Marie, Murphy, Rachel A., Nevanlinna, Heli, Nevelsteen, Ines, Newman, William G., Offit, Kenneth, Olshan, Andrew F., Olsson, Håkan, Orr, Nick, Patel, Alpa V., Peto, Julian, Plaseska-Karanfilska, Dijana, Presneau, Nadege, Rack, Brigitte, Radice, Paolo, Rees-Punia, Erika, Rennert, Gad, Rennert, Hedy S., Romero, Atocha, Saloustros, Emmanouil, Sandler, Dale P., Schmidt, Marjanka K, Schmutzler, Rita K., Schwentner, Lukas, Scott, Christopher, Shah, Mitul, Shu, Xiao Ou, Simard, Jacques, Southey, Melissa C., Stone, Jennifer, Surowy, Harald, Swerdlow, Anthony J., Tamimi, Rulla M., Tapper, William J., Taylor, Jack A., Terry, Mary Beth, Tollenaar, Rob A.E.M., Troester, Melissa A., Truong, Thérèse, Untch, Michael, Vachon, Celine M., Joseph, Vijai, Wappenschmidt, Barbara, Weinberg, Clarice R., Wolk, Alicja, Yannoukakos, Drakoulis, Zheng, Wei, Ziogas, Argyrios, Dunning, Alison M., Pharoah, Paul D.P., Easton, Douglas F., Milne, Roger L., Lynch, Brigid M., Dixon-Suen, Suzanne C., Lewis, Sarah J., Martin, Richard M., English, Dallas R., Boyle, Terry, Giles, Graham G., Michailidou, Kyriaki, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Lush, Michael, Ahearn, Thomas U., Ambrosone, Christine B., Andrulis, Irene L., Anton-Culver, Hoda, Arndt, Volker, Aronson, Kristan J., Augustinsson, Annelie, Auvinen, Päivi, Freeman, Laura E.Beane, Becher, Heiko, Beckmann, Matthias W., Behrens, Sabine, Bermisheva, Marina, Blomqvist, Carl, Bogdanova, Natalia V., Bojesen, Stig E., Bonanni, Bernardo, Brenner, Hermann, Brüning, Thomas, Buys, Saundra S., Camp, Nicola J., Campa, Daniele, Canzian, Federico, Castelao, Jose E., Cessna, Melissa H., Chang-Claude, Jenny, Chanock, Stephen J., Clarke, Christine L., Conroy, Don M., Couch, Fergus J., Cox, Angela, Cross, Simon S., Czene, Kamila, Daly, Mary B., Devilee, Peter, Dörk, Thilo, Dwek, Miriam, Eccles, Diana M., Eliassen, A. Heather, Engel, Christoph, Eriksson, Mikael, Evans, D. Gareth, Fasching, Peter A., Fletcher, Olivia, Flyger, Henrik, Fritschi, Lin, Gabrielson, Marike, Gago-Dominguez, Manuela, García-Closas, Montserrat, Goldberg, Mark S., Guénel, Pascal, Gündert, Melanie, Hahnen, Eric, Haiman, Christopher A., Häberle, Lothar, Håkansson, Niclas, Hall, Per, Hamann, Ute, Hart, Steven N., Harvie, Michelle, Hillemanns, Peter, Hollestelle, Antoinette, Hooning, Maartje J., Hoppe, Reiner, Hopper, John L., Howell, Anthony, Hunter, David J., Jakubowska, Anna, Janni, Wolfgang, John, Esther M., Jung, Audrey Y., Kaaks, Rudolf, Keeman, Renske, Kitahara, Cari M., Koutros, Stella, Kraft, Peter, Kristensen, Vessela N., Kubelka-Sabit, Katerina, Kurian, Allison W., Lacey, James V., Lambrechts, Diether, Marchand, Loic Le, Lindblom, Annika, Loibl, Sibylle, Lubiński, Jan, Mannermaa, Arto, Manoochehri, Mehdi, Margolin, Sara, Martinez, Maria Elena, Mavroudis, Dimitrios, Menon, Usha, Mulligan, Anna Marie, Murphy, Rachel A., Nevanlinna, Heli, Nevelsteen, Ines, Newman, William G., Offit, Kenneth, Olshan, Andrew F., Olsson, Håkan, Orr, Nick, Patel, Alpa V., Peto, Julian, Plaseska-Karanfilska, Dijana, Presneau, Nadege, Rack, Brigitte, Radice, Paolo, Rees-Punia, Erika, Rennert, Gad, Rennert, Hedy S., Romero, Atocha, Saloustros, Emmanouil, Sandler, Dale P., Schmidt, Marjanka K, Schmutzler, Rita K., Schwentner, Lukas, Scott, Christopher, Shah, Mitul, Shu, Xiao Ou, Simard, Jacques, Southey, Melissa C., Stone, Jennifer, Surowy, Harald, Swerdlow, Anthony J., Tamimi, Rulla M., Tapper, William J., Taylor, Jack A., Terry, Mary Beth, Tollenaar, Rob A.E.M., Troester, Melissa A., Truong, Thérèse, Untch, Michael, Vachon, Celine M., Joseph, Vijai, Wappenschmidt, Barbara, Weinberg, Clarice R., Wolk, Alicja, Yannoukakos, Drakoulis, Zheng, Wei, Ziogas, Argyrios, Dunning, Alison M., Pharoah, Paul D.P., Easton, Douglas F., Milne, Roger L., and Lynch, Brigid M.

Abstract

Objectives Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast cancer risk overall, pre/post-menopause, and by case-groups defined by tumour characteristics. Methods We performed two-sample inverse-variance-weighted MR using individual-level Breast Cancer Association Consortium case-control data from 130 957 European-ancestry women (69 838 invasive cases), and published UK Biobank data (n=91 105-377 234). Genetic instruments were single nucleotide polymorphisms (SNPs) associated in UK Biobank with wrist-worn accelerometer-measured overall physical activity (n snps =5) or sedentary time (n snps =6), or accelerometer-measured (n snps =1) or self-reported (n snps =5) vigorous physical activity. Results Greater genetically-predicted overall activity was associated with lower breast cancer overall risk (OR=0.59; 95% confidence interval (CI) 0.42 to 0.83 per-standard deviation (SD;∼8 milligravities acceleration)) and for most case-groups. Genetically-predicted vigorous activity was associated with lower risk of pre/perimenopausal breast cancer (OR=0.62; 95% CI 0.45 to 0.87,≥3 vs. 0 self-reported days/week), with consistent estimates for most case-groups. Greater genetically-predicted sedentary time was associated with higher hormone-receptor-negative tumour risk (OR=1.77; 95% CI 1.07 to 2.92 per-SD (∼7% time spent sedentary)), with elevated estimates for most case-groups. Results were robust to sensitivity analyses examining pleiotropy (including weighted-median-MR, MR-Egger). Conclusion Our study provides strong evidence that greater overall physical activity, greater vigorous activity, and lower sedentary time a

Published
2022

45. American Cancer Society nutrition and physical activity guideline for cancer survivors

Author

Rock, Cheryl L., primary, Thomson, Cynthia A., additional, Sullivan, Kristen R., additional, Howe, Carol L., additional, Kushi, Lawrence H., additional, Caan, Bette J., additional, Neuhouser, Marian L., additional, Bandera, Elisa V., additional, Wang, Ying, additional, Robien, Kimberly, additional, Basen‐Engquist, Karen M., additional, Brown, Justin C., additional, Courneya, Kerry S., additional, Crane, Tracy E., additional, Garcia, David O., additional, Grant, Barbara L., additional, Hamilton, Kathryn K., additional, Hartman, Sheri J., additional, Kenfield, Stacey A., additional, Martinez, Maria Elena, additional, Meyerhardt, Jeffrey A., additional, Nekhlyudov, Larissa, additional, Overholser, Linda, additional, Patel, Alpa V., additional, Pinto, Bernardine M., additional, Platek, Mary E., additional, Rees‐Punia, Erika, additional, Spees, Colleen K., additional, Gapstur, Susan M., additional, and McCullough, Marjorie L., additional

Published
2022
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49. Abstract 13917: A Harmonized Meta-Analysis of the Associations of Steps per Day With Incident Cardiovascular Disease

Author

Paluch, Amanda E, primary, Bajpai, Shivangi, additional, Bassett, David R, additional, Chernofsky, Ariel, additional, Carnethon, Mercedes, additional, Dooley, Erin, additional, Ekelund, Ulf, additional, Evenson, Kelly R, additional, Pettee Gabriel, Kelley P, additional, Galuska, Deborah A, additional, Jefferis, Barbara J, additional, Kraus, William E, additional, Larson, Martin, additional, Lee, I-min M, additional, matthews, charles, additional, Newton, Robert L, additional, Omura, John D, additional, Palta, Priya, additional, Pieper, Carl, additional, Rees-Punia, Erika, additional, Pompeii, Lisa, additional, Rippon, Brady, additional, Spartano, Nicole L, additional, Ramachandran, Vasan S, additional, Yang, Shengping, additional, and Fulton, Janet E, additional

Published
2021
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50. Effects of School Gardening Lessons on Elementary School Children's Physical Activity and Sedentary Time.

Author

Rees-Punia, Erika, Holloway, Alicia, Knauft, David, and Schmidt, Michael D.

Subjects
PHYSICAL education, SCHOOL gardens, SCHOOL recess breaks, GARDENS & education, ELEMENTARY education
Abstract

Background: Recess and physical education time continue to diminish, creating a need for additional physical activity opportunities within the school environment. The use of school gardens as a teaching tool in elementary science and math classes has the potential to increase the proportion of time spent active throughout the school day. Methods: Teachers from 4 elementary schools agreed to teach 1 math or science lesson per week in the school garden. Student physical activity time was measured with ActiGraph GT3X accelerometers on 3 garden days and 3 no-garden days at each school. Direct observation was used to quantify the specific garden-related tasks during class. The proportion of time spent active and sedentary was compared on garden and nogarden days. Results: Seventy-four children wore accelerometers, and 75 were observed (86% participation). Children spent a significantly larger proportion of time active on garden days than no-garden days at 3 of the 4 schools. The proportion of time spent sedentary and active differed significantly across the 4 schools. Conclusions: Teaching lessons in the school garden may increase children's physical activity and decrease sedentary time throughout the school day and may be a strategy to promote both health and learning. [ABSTRACT FROM AUTHOR]

Published
2017
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