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311 results on '"Rees, Matthew G."'

1. Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition

Author

Shendy, Noha A. M., Bikowitz, Melissa, Sigua, Logan H., Zhang, Yang, Mercier, Audrey, Khashana, Yousef, Nance, Stephanie, Liu, Qi, Delahunty, Ian M., Robinson, Sarah, Goel, Vanshita, Rees, Matthew G., Ronan, Melissa A., Wang, Tingjian, Kocak, Mustafa, Roth, Jennifer A., Wang, Yingzhe, Freeman, Burgess B., Orr, Brent A., Abraham, Brian J., Roussel, Martine F., Schonbrunn, Ernst, Qi, Jun, and Durbin, Adam D.

Published
2024
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2. Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer

Author

Wasko, Urszula N., Jiang, Jingjing, Dalton, Tanner C., Curiel-Garcia, Alvaro, Edwards, A. Cole, Wang, Yingyun, Lee, Bianca, Orlen, Margo, Tian, Sha, Stalnecker, Clint A., Drizyte-Miller, Kristina, Menard, Marie, Dilly, Julien, Sastra, Stephen A., Palermo, Carmine F., Hasselluhn, Marie C., Decker-Farrell, Amanda R., Chang, Stephanie, Jiang, Lingyan, Wei, Xing, Yang, Yu C., Helland, Ciara, Courtney, Haley, Gindin, Yevgeniy, Muonio, Karl, Zhao, Ruiping, Kemp, Samantha B., Clendenin, Cynthia, Sor, Rina, Vostrejs, William P., Hibshman, Priya S., Amparo, Amber M., Hennessey, Connor, Rees, Matthew G., Ronan, Melissa M., Roth, Jennifer A., Brodbeck, Jens, Tomassoni, Lorenzo, Bakir, Basil, Socci, Nicholas D., Herring, Laura E., Barker, Natalie K., Wang, Junning, Cleary, James M., Wolpin, Brian M., Chabot, John A., Kluger, Michael D., Manji, Gulam A., Tsai, Kenneth Y., Sekulic, Miroslav, Lagana, Stephen M., Califano, Andrea, Quintana, Elsa, Wang, Zhengping, Smith, Jacqueline A. M., Holderfield, Matthew, Wildes, David, Lowe, Scott W., Badgley, Michael A., Aguirre, Andrew J., Vonderheide, Robert H., Stanger, Ben Z., Baslan, Timour, Der, Channing J., Singh, Mallika, and Olive, Kenneth P.

Published
2024
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3. Author Correction: Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer

Author

Wasko, Urszula N., Jiang, Jingjing, Dalton, Tanner C., Curiel-Garcia, Alvaro, Edwards, A. Cole, Wang, Yingyun, Lee, Bianca, Orlen, Margo, Tian, Sha, Stalnecker, Clint A., Drizyte-Miller, Kristina, Menard, Marie, Dilly, Julien, Sastra, Stephen A., Palermo, Carmine F., Hasselluhn, Marie C., Decker-Farrell, Amanda R., Chang, Stephanie, Jiang, Lingyan, Wei, Xing, Yang, Yu C., Helland, Ciara, Courtney, Haley, Gindin, Yevgeniy, Muonio, Karl, Zhao, Ruiping, Kemp, Samantha B., Clendenin, Cynthia, Sor, Rina, Vostrejs, William P., Hibshman, Priya S., Amparo, Amber M., Hennessey, Connor, Rees, Matthew G., Ronan, Melissa M., Roth, Jennifer A., Brodbeck, Jens, Tomassoni, Lorenzo, Bakir, Basil, Socci, Nicholas D., Herring, Laura E., Barker, Natalie K., Wang, Junning, Cleary, James M., Wolpin, Brian M., Chabot, John A., Kluger, Michael D., Manji, Gulam A., Tsai, Kenneth Y., Sekulic, Miroslav, Lagana, Stephen M., Califano, Andrea, Quintana, Elsa, Wang, Zhengping, Smith, Jacqueline A. M., Holderfield, Matthew, Wildes, David, Lowe, Scott W., Badgley, Michael A., Aguirre, Andrew J., Vonderheide, Robert H., Stanger, Ben Z., Baslan, Timour, Der, Channing J., Singh, Mallika, and Olive, Kenneth P.

Published
2024
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4. Targeting ROS production through inhibition of NADPH oxidases

Author

Reis, Joana, Gorgulla, Christoph, Massari, Marta, Marchese, Sara, Valente, Sergio, Noce, Beatrice, Basile, Lorenzo, Törner, Ricarda, Cox, III, Huel, Viennet, Thibault, Yang, Moon Hee, Ronan, Melissa M., Rees, Matthew G., Roth, Jennifer A., Capasso, Lucia, Nebbioso, Angela, Altucci, Lucia, Mai, Antonello, Arthanari, Haribabu, and Mattevi, Andrea

Published
2023
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5. The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity

Author

Baumgartner, Christina K., Ebrahimi-Nik, Hakimeh, Iracheta-Vellve, Arvin, Hamel, Keith M., Olander, Kira E., Davis, Thomas G. R., McGuire, Kathleen A., Halvorsen, Geoff T., Avila, Omar I., Patel, Chirag H., Kim, Sarah Y., Kammula, Ashwin V., Muscato, Audrey J., Halliwill, Kyle, Geda, Prasanthi, Klinge, Kelly L., Xiong, Zhaoming, Duggan, Ryan, Mu, Liang, Yeary, Mitchell D., Patti, James C., Balon, Tyler M., Mathew, Rebecca, Backus, Carey, Kennedy, Domenick E., Chen, Angeline, Longenecker, Kenton, Klahn, Joseph T., Hrusch, Cara L., Krishnan, Navasona, Hutchins, Charles W., Dunning, Jax P., Bulic, Marinka, Tiwari, Payal, Colvin, Kayla J., Chuong, Cun Lan, Kohnle, Ian C., Rees, Matthew G., Boghossian, Andrew, Ronan, Melissa, Roth, Jennifer A., Wu, Meng-Ju, Suermondt, Juliette S. M. T., Knudsen, Nelson H., Cheruiyot, Collins K., Sen, Debattama R., Griffin, Gabriel K., Golub, Todd R., El-Bardeesy, Nabeel, Decker, Joshua H., Yang, Yi, Guffroy, Magali, Fossey, Stacey, Trusk, Patricia, Sun, Im-Meng, Liu, Yue, Qiu, Wei, Sun, Qi, Paddock, Marcia N., Farney, Elliot P., Matulenko, Mark A., Beauregard, Clay, Frost, Jennifer M., Yates, Kathleen B., Kym, Philip R., and Manguso, Robert T.

Published
2023
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11. Screening in serum-derived medium reveals differential response to compounds targeting metabolism

Author

Abbott, Keene L., Ali, Ahmed, Casalena, Dominick, Do, Brian T., Ferreira, Raphael, Cheah, Jaime H., Soule, Christian K., Deik, Amy, Kunchok, Tenzin, Schmidt, Daniel R., Renner, Steffen, Honeder, Sophie E., Wu, Michelle, Chan, Sze Ham, Tseyang, Tenzin, Stoltzfus, Andrew T., Michel, Sarah L.J., Greaves, Daniel, Hsu, Peggy P., Ng, Christopher W., Zhang, Chelsea J., Farsidjani, Ali, Kent, Johnathan R., Madariaga, Maria Lucia L., Gramatikov, Iva Monique T., Matheson, Nicholas J., Lewis, Caroline A., Clish, Clary B., Rees, Matthew G., Roth, Jennifer A., Griner, Lesley Mathews, Muir, Alexander, Auld, Douglas S., and Vander Heiden, Matthew G.

Published
2023
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12. The insistent image, and, The Word : an exploration of the creative force of insistent mental imagery in the writing of short stories

Author

Rees, Matthew G., Gower, D. Jonathan, and Britton, David J.

Subjects
808.3
Abstract

The purpose of this research is to explore the phenomenon of insistent mental imagery as a creative force in the writing of short stories. The research has two elements. Firstly, the praxis of the creative work: experimental writing functioning as research, leading to an original body of work entitled The Word, a collection of twenty-one short stories amounting to 75,000 words unified by their association with Wales and the Marches and the inclination of their subject matter to the supernatural and the enigmatic. Secondly, this thesis features the gnosis, an essay titled 'The Insistent Image', which explores the creative force of mental imagery in the writing of short stories by noted exponents of the short story form and the influence of such imagery on the candidate's own short fiction. This essay will argue that the importance of imagery in short stories is felt not merely after the ending of a piece of a fiction, but in its formative stages, and tellingly so. This research contributes to our understanding of how and why short stories are written. It significantly widens discussion of the part played by mental imagery in the formative stages of short story writing, hitherto an area of relatively limited discourse and investigation. The author demonstrates the role of received mental imagery as an important driver in the writing of his own short fiction, also citing its influence on other writers and their stories. The case is made that mental imagery has a singular influence on fiction in the short form, consonant with the short story's occupation with moment and glimpse. The case is also made that as a form the short story provides the optimal window in prose fiction for what the author terms the insistent image to crystallize, spawn sibling imagery and shape the course of a text of fiction.

Published
2019
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14. Targeted Degradation of CDK9 Potently Disrupts the MYC Transcriptional Network

Author

Toure, Mohammed A, primary, Motoyama, Keisuke, additional, Xiang, Yichen, additional, Urgiles, Julie, additional, Kabinger, Florian, additional, Koglin, Ann-Sophie, additional, Iyer, Ramya S, additional, Gagnon, Kaitlyn, additional, Kumar, Amruth, additional, Ojeda, Samuel, additional, Harrison, Drew A, additional, Rees, Matthew G, additional, Roth, Jennifer A, additional, Ott, Christopher J, additional, Schiavoni, Richard, additional, Whittaker, Charles A, additional, Levine, Stuart S, additional, White, Forest M, additional, Calo, Eliezer, additional, Richters, André, additional, and Koehler, Angela N, additional

Published
2024
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15. Data from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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16. Supplementary Data File 2 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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17. Supplementary Figure 15 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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18. Supplementary Table 1 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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19. Supplementary Data File 1 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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20. Supplementary Methods from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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21. Supplementary Figure 2 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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22. Supplementary Table 2 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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23. Supplementary Figure 9 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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24. Supplementary Data File 3 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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25. Supplementary Figure 6 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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26. Supplementary Figure 3 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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27. Supplementary Figure 4 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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28. Supplementary Figure 8 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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29. Supplementary Figure 5 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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30. Supplementary Figure 7 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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32. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Author

Viswanathan, Vasanthi S, Ryan, Matthew J, Dhruv, Harshil D, Gill, Shubhroz, Eichhoff, Ossia M, Seashore-Ludlow, Brinton, Kaffenberger, Samuel D, Eaton, John K, Shimada, Kenichi, Aguirre, Andrew J, Viswanathan, Srinivas R, Chattopadhyay, Shrikanta, Tamayo, Pablo, Yang, Wan Seok, Rees, Matthew G, Chen, Sixun, Boskovic, Zarko V, Javaid, Sarah, Huang, Cherrie, Wu, Xiaoyun, Tseng, Yuen-Yi, Roider, Elisabeth M, Gao, Dong, Cleary, James M, Wolpin, Brian M, Mesirov, Jill P, Haber, Daniel A, Engelman, Jeffrey A, Boehm, Jesse S, Kotz, Joanne D, Hon, Cindy S, Chen, Yu, Hahn, William C, Levesque, Mitchell P, Doench, John G, Berens, Michael E, Shamji, Alykhan F, Clemons, Paul A, Stockwell, Brent R, and Schreiber, Stuart L

Subjects
Cancer, Cadherins, Cell Death, Cell Line, Tumor, Cell Lineage, Cell Transdifferentiation, Drug Resistance, Neoplasm, Epithelial-Mesenchymal Transition, Glutathione Peroxidase, Humans, Iron, Lipid Peroxidation, Lipid Peroxides, Male, Melanoma, Mesoderm, Neoplasms, Phospholipid Hydroperoxide Glutathione Peroxidase, Prostatic Neoplasms, Proteomics, Proto-Oncogene Proteins B-raf, Reproducibility of Results, Zinc Finger E-box-Binding Homeobox 1, General Science & Technology
Abstract

Plasticity of the cell state has been proposed to drive resistance to multiple classes of cancer therapies, thereby limiting their effectiveness. A high-mesenchymal cell state observed in human tumours and cancer cell lines has been associated with resistance to multiple treatment modalities across diverse cancer lineages, but the mechanistic underpinning for this state has remained incompletely understood. Here we molecularly characterize this therapy-resistant high-mesenchymal cell state in human cancer cell lines and organoids and show that it depends on a druggable lipid-peroxidase pathway that protects against ferroptosis, a non-apoptotic form of cell death induced by the build-up of toxic lipid peroxides. We show that this cell state is characterized by activity of enzymes that promote the synthesis of polyunsaturated lipids. These lipids are the substrates for lipid peroxidation by lipoxygenase enzymes. This lipid metabolism creates a dependency on pathways converging on the phospholipid glutathione peroxidase (GPX4), a selenocysteine-containing enzyme that dissipates lipid peroxides and thereby prevents the iron-mediated reactions of peroxides that induce ferroptotic cell death. Dependency on GPX4 was found to exist across diverse therapy-resistant states characterized by high expression of ZEB1, including epithelial-mesenchymal transition in epithelial-derived carcinomas, TGFβ-mediated therapy-resistance in melanoma, treatment-induced neuroendocrine transdifferentiation in prostate cancer, and sarcomas, which are fixed in a mesenchymal state owing to their cells of origin. We identify vulnerability to ferroptic cell death induced by inhibition of a lipid peroxidase pathway as a feature of therapy-resistant cancer cells across diverse mesenchymal cell-state contexts.

Published
2017

34. Supplemental Table 5 from A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma

Author

Hwang, Grace H., primary, Pazyra-Murphy, Maria F., primary, Seo, Hyuk-Soo, primary, Dhe-Paganon, Sirano, primary, Stopka, Sylwia A., primary, DiPiazza, Marina, primary, Sutter, Nizhoni, primary, Gero, Thomas W., primary, Volkert, Alison, primary, Ombelets, Lincoln, primary, Dittemore, Georgia, primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Agar, Nathalie Y.R., primary, Scott, David A., primary, and Segal, Rosalind A., primary

Published
2024
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35. Supplemental Table 2 from A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma

Author

Hwang, Grace H., primary, Pazyra-Murphy, Maria F., primary, Seo, Hyuk-Soo, primary, Dhe-Paganon, Sirano, primary, Stopka, Sylwia A., primary, DiPiazza, Marina, primary, Sutter, Nizhoni, primary, Gero, Thomas W., primary, Volkert, Alison, primary, Ombelets, Lincoln, primary, Dittemore, Georgia, primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Agar, Nathalie Y.R., primary, Scott, David A., primary, and Segal, Rosalind A., primary

Published
2024
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36. Supplementary Figures from A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma

Author

Hwang, Grace H., primary, Pazyra-Murphy, Maria F., primary, Seo, Hyuk-Soo, primary, Dhe-Paganon, Sirano, primary, Stopka, Sylwia A., primary, DiPiazza, Marina, primary, Sutter, Nizhoni, primary, Gero, Thomas W., primary, Volkert, Alison, primary, Ombelets, Lincoln, primary, Dittemore, Georgia, primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Agar, Nathalie Y.R., primary, Scott, David A., primary, and Segal, Rosalind A., primary

Published
2024
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37. Supplemental Table 4 from A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma

Author

Hwang, Grace H., primary, Pazyra-Murphy, Maria F., primary, Seo, Hyuk-Soo, primary, Dhe-Paganon, Sirano, primary, Stopka, Sylwia A., primary, DiPiazza, Marina, primary, Sutter, Nizhoni, primary, Gero, Thomas W., primary, Volkert, Alison, primary, Ombelets, Lincoln, primary, Dittemore, Georgia, primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Agar, Nathalie Y.R., primary, Scott, David A., primary, and Segal, Rosalind A., primary

Published
2024
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38. Supplementary Data from A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma

Author

Hwang, Grace H., primary, Pazyra-Murphy, Maria F., primary, Seo, Hyuk-Soo, primary, Dhe-Paganon, Sirano, primary, Stopka, Sylwia A., primary, DiPiazza, Marina, primary, Sutter, Nizhoni, primary, Gero, Thomas W., primary, Volkert, Alison, primary, Ombelets, Lincoln, primary, Dittemore, Georgia, primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Agar, Nathalie Y.R., primary, Scott, David A., primary, and Segal, Rosalind A., primary

Published
2024
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39. Supplemental Table 3 from A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma

Author

Hwang, Grace H., primary, Pazyra-Murphy, Maria F., primary, Seo, Hyuk-Soo, primary, Dhe-Paganon, Sirano, primary, Stopka, Sylwia A., primary, DiPiazza, Marina, primary, Sutter, Nizhoni, primary, Gero, Thomas W., primary, Volkert, Alison, primary, Ombelets, Lincoln, primary, Dittemore, Georgia, primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Agar, Nathalie Y.R., primary, Scott, David A., primary, and Segal, Rosalind A., primary

Published
2024
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40. Supplemental Table 6 from A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma

Author

Hwang, Grace H., primary, Pazyra-Murphy, Maria F., primary, Seo, Hyuk-Soo, primary, Dhe-Paganon, Sirano, primary, Stopka, Sylwia A., primary, DiPiazza, Marina, primary, Sutter, Nizhoni, primary, Gero, Thomas W., primary, Volkert, Alison, primary, Ombelets, Lincoln, primary, Dittemore, Georgia, primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Agar, Nathalie Y.R., primary, Scott, David A., primary, and Segal, Rosalind A., primary

Published
2024
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41. Supplemental Table 1 from A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma

Author

Hwang, Grace H., primary, Pazyra-Murphy, Maria F., primary, Seo, Hyuk-Soo, primary, Dhe-Paganon, Sirano, primary, Stopka, Sylwia A., primary, DiPiazza, Marina, primary, Sutter, Nizhoni, primary, Gero, Thomas W., primary, Volkert, Alison, primary, Ombelets, Lincoln, primary, Dittemore, Georgia, primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Agar, Nathalie Y.R., primary, Scott, David A., primary, and Segal, Rosalind A., primary

Published
2024
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42. Data from A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma

Author

Hwang, Grace H., primary, Pazyra-Murphy, Maria F., primary, Seo, Hyuk-Soo, primary, Dhe-Paganon, Sirano, primary, Stopka, Sylwia A., primary, DiPiazza, Marina, primary, Sutter, Nizhoni, primary, Gero, Thomas W., primary, Volkert, Alison, primary, Ombelets, Lincoln, primary, Dittemore, Georgia, primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Agar, Nathalie Y.R., primary, Scott, David A., primary, and Segal, Rosalind A., primary

Published
2024
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43. A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma

Author

Hwang, Grace H., primary, Pazyra-Murphy, Maria F., additional, Seo, Hyuk-Soo, additional, Dhe-Paganon, Sirano, additional, Stopka, Sylwia A., additional, DiPiazza, Marina, additional, Sutter, Nizhoni, additional, Gero, Thomas W., additional, Volkert, Alison, additional, Ombelets, Lincoln, additional, Dittemore, Georgia, additional, Rees, Matthew G., additional, Ronan, Melissa M., additional, Roth, Jennifer A., additional, Agar, Nathalie Y.R., additional, Scott, David A., additional, and Segal, Rosalind A., additional

Published
2024
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44. DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets

Author

Hanaford, Allison R, Archer, Tenley C, Price, Antoinette, Kahlert, Ulf D, Maciaczyk, Jarek, Nikkhah, Guido, Kim, Jong Wook, Ehrenberger, Tobias, Clemons, Paul A, Dančík, Vlado, Seashore-Ludlow, Brinton, Viswanathan, Vasanthi, Stewart, Michelle L, Rees, Matthew G, Shamji, Alykhan, Schreiber, Stuart, Fraenkel, Ernest, Pomeroy, Scott L, Mesirov, Jill P, Tamayo, Pablo, Eberhart, Charles G, and Raabe, Eric H

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Stem Cell Research, Pediatric Research Initiative, Brain Disorders, Orphan Drug, Neurosciences, Stem Cell Research - Nonembryonic - Non-Human, Rare Diseases, Stem Cell Research - Nonembryonic - Human, Brain Cancer, Cancer, Pediatric Cancer, Biotechnology, Pediatric, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Animals, Apoptosis, Biomarkers, Cell Line, Tumor, Cerebellar Neoplasms, Computational Biology, Computer Simulation, Cyclin-Dependent Kinases, Disease Models, Animal, Drug Discovery, Gene Expression Profiling, Genetic Predisposition to Disease, Humans, Medulloblastoma, Mice, Models, Biological, Neural Stem Cells, Phosphorylation, Piperazines, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins c-myc, Pyridines, Transcriptome, Tumor Suppressor Protein p53, Xenograft Model Antitumor Assays, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

PurposeWe used human stem and progenitor cells to develop a genetically accurate novel model of MYC-driven Group 3 medulloblastoma. We also developed a new informatics method, Disease-model Signature versus Compound-Variety Enriched Response ("DiSCoVER"), to identify novel therapeutics that target this specific disease subtype.Experimental designHuman neural stem and progenitor cells derived from the cerebellar anlage were transduced with oncogenic elements associated with aggressive medulloblastoma. An in silico analysis method for screening drug sensitivity databases (DiSCoVER) was used in multiple drug sensitivity datasets. We validated the top hits from this analysis in vitro and in vivoResultsHuman neural stem and progenitor cells transformed with c-MYC, dominant-negative p53, constitutively active AKT and hTERT formed tumors in mice that recapitulated Group 3 medulloblastoma in terms of pathology and expression profile. DiSCoVER analysis predicted that aggressive MYC-driven Group 3 medulloblastoma would be sensitive to cyclin-dependent kinase (CDK) inhibitors. The CDK 4/6 inhibitor palbociclib decreased proliferation, increased apoptosis, and significantly extended the survival of mice with orthotopic medulloblastoma xenografts.ConclusionsWe present a new method to generate genetically accurate models of rare tumors, and a companion computational methodology to find therapeutic interventions that target them. We validated our human neural stem cell model of MYC-driven Group 3 medulloblastoma and showed that CDK 4/6 inhibitors are active against this subgroup. Our results suggest that palbociclib is a potential effective treatment for poor prognosis MYC-driven Group 3 medulloblastoma tumors in carefully selected patients. Clin Cancer Res; 22(15); 3903-14. ©2016 AACR.

Published
2016

45. Discovering the anticancer potential of non-oncology drugs by systematic viability profiling

Author

Corsello, Steven M., Nagari, Rohith T., Spangler, Ryan D., Rossen, Jordan, Kocak, Mustafa, Bryan, Jordan G., Humeidi, Ranad, Peck, David, Wu, Xiaoyun, Tang, Andrew A., Wang, Vickie M., Bender, Samantha A., Lemire, Evan, Narayan, Rajiv, Montgomery, Philip, Ben-David, Uri, Garvie, Colin W., Chen, Yejia, Rees, Matthew G., Lyons, Nicholas J., McFarland, James M., Wong, Bang T., Wang, Li, Dumont, Nancy, O’Hearn, Patrick J., Stefan, Eric, Doench, John G., Harrington, Caitlin N., Greulich, Heidi, Meyerson, Matthew, Vazquez, Francisca, Subramanian, Aravind, Roth, Jennifer A., Bittker, Joshua A., Boehm, Jesse S., Mader, Christopher C., Tsherniak, Aviad, and Golub, Todd R.

Published
2020
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46. Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors

Author

Oberlick, Elaine M., Rees, Matthew G., Seashore-Ludlow, Brinton, Vazquez, Francisca, Nelson, Geoffrey M., Dharia, Neekesh V., Weir, Barbara A., Tsherniak, Aviad, Ghandi, Mahmoud, Krill-Burger, John M., Meyers, Robin M., Wang, Xiaofeng, Montgomery, Phil, Root, David E., Bieber, Jake M., Radko, Sandi, Cheah, Jaime H., Hon, C. Suk-Yee, Shamji, Alykhan F., Clemons, Paul A., Park, Peter J., Dyer, Michael A., Golub, Todd R., Stegmaier, Kimberly, Hahn, William C., Stewart, Elizabeth A., Schreiber, Stuart L., and Roberts, Charles W.M.

Published
2019
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47. Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers

Author

Payton, Marc, primary, Belmontes, Brian, additional, Hanestad, Kelly, additional, Moriguchi, Jodi, additional, Chen, Kui, additional, McCarter, John D., additional, Chung, Grace, additional, Ninniri, Maria Stefania, additional, Sun, Jan, additional, Manoukian, Raffi, additional, Chambers, Stuart, additional, Ho, Seok-Man, additional, Kurzeja, Robert J. M., additional, Edson, Katheryne Z., additional, Dahal, Upendra P., additional, Wu, Tian, additional, Wannberg, Sharon, additional, Beltran, Pedro J., additional, Canon, Jude, additional, Boghossian, Andrew S., additional, Rees, Matthew G., additional, Ronan, Melissa M., additional, Roth, Jennifer A., additional, Minocherhomji, Sheroy, additional, Bourbeau, Matthew P., additional, Allen, Jennifer R., additional, Coxon, Angela, additional, Tamayo, Nuria A., additional, and Hughes, Paul E., additional

Published
2023
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48. 4’-Ethynyl-2’-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress

Author

Calbert, Marissa L., primary, Chandramouly, Gurushankar, additional, Adams, Clare M., additional, Saez-Ayala, Magali, additional, Kent, Tatiana, additional, Tyagi, Mrityunjay, additional, Ayyadevara, V.S.S. Abhinav, additional, Wang, Yifan, additional, Krais, John J., additional, Gordon, John, additional, Atkins, Jessica, additional, Toma, Monika M., additional, Betzi, Stéphane, additional, Boghossian, Andrew S., additional, Rees, Matthew G., additional, Ronan, Melissa M., additional, Roth, Jennifer A., additional, Goldman, Aaron R., additional, Gorman, Nicole, additional, Mitra, Ramkrishna, additional, Childers, Wayne E., additional, Graña, Xavier, additional, Skorski, Tomasz, additional, Johnson, Neil, additional, Hurtz, Christian, additional, Morelli, Xavier, additional, Eischen, Christine M., additional, and Pomerantz, Richard T., additional

Published
2023
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49. Tumor-selective effects of active RAS inhibition in pancreatic ductal adenocarcinoma

Author

Wasko, Urszula N., primary, Jiang, Jingjing, additional, Curiel-Garcia, Alvaro, additional, Wang, Yingyun, additional, Lee, Bianca, additional, Orlen, Margo, additional, Drizyte-Miller, Kristina, additional, Menard, Marie, additional, Dilly, Julien, additional, Sastra, Stephen A., additional, Palermo, Carmine F., additional, Dalton, Tanner, additional, Hasselluhn, Marie C., additional, Decker-Farrell, Amanda R., additional, Chang, Stephanie, additional, Jiang, Lingyan, additional, Wei, Xing, additional, Yang, Yu C., additional, Helland, Ciara, additional, Courtney, Haley, additional, Gindin, Yevgeniy, additional, Zhao, Ruiping, additional, Kemp, Samantha B., additional, Clendenin, Cynthia, additional, Sor, Rina, additional, Vostrejs, Will, additional, Amparo, Amber A., additional, Hibshman, Priya S., additional, Rees, Matthew G., additional, Ronan, Melissa M., additional, Roth, Jennifer A., additional, Bakir, Basil, additional, Badgley, Michael A., additional, Chabot, John A., additional, Kluger, Michael D., additional, Manji, Gulam A., additional, Quintana, Elsa, additional, Wang, Zhengping, additional, Smith, Jacqueline A. M., additional, Holderfield, Matthew, additional, Wildes, David, additional, Aguirre, Andrew J., additional, Der, Channing J., additional, Vonderheide, Robert H., additional, Stanger, Ben Z., additional, Singh, Mallika, additional, and Olive, Kenneth P., additional

Published
2023
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50. Oncogenic cells of renal embryonic lineage sensitive to the small molecule inhibitor QC6352 display depletion of KDM4 levels and disruption of ribosome biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., additional, Fang, Jie, additional, Fleming, Andrew M., additional, Gil, Hyea Jin, additional, Boghossian, Andrew S., additional, Rees, Matthew G., additional, Ronan, Melissa M., additional, Roth, Jennifer A., additional, Morton, Christopher L., additional, Zambetti, Gerard P., additional, Davidoff, Andrew M., additional, Yang, Jun, additional, and Murphy, Andrew J., additional

Published
2023
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