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3,603 results on '"Rees, David"'

1. Impact of BCR::ABL1 single nucleotide variants on asciminib efficacy

Author

Innes, Andrew J., Hayden, Chloe, Orovboni, Victoria, Claudiani, Simone, Fernando, Fiona, Khan, Afzal, Rees, David, Byrne, Jennifer, Gallipoli, Paolo, Francis, Sebastian, Copland, Mhairi, Horne, Gillian, Raghavan, Manoj, Arnold, Claire, Collins, Angela, Cranfield, Tanya, Cunningham, Nicholas, Danga, Akila, Forsyth, Peter, Frewin, Rebecca, Garland, Paula, Hannah, Guy, Avenoso, Daniele, Hassan, Sandra, Huntly, Brian J. P., Husain, Jissan, Makkuni, Sudhakaran, Rothwell, Kate, Khorashad, Jamshid, Apperley, Jane F., and Milojkovic, Dragana

Published
2024
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5. On dynamical ordering in a 2D electron crystal confined in a narrow channel geometry

Author

Zou, Shan, Rees, David G., and Konstantinov, Denis

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

We present both time-averaged and time-resolved transport measurements of a two-dimensional electron (Wigner) crystal on the surface of superfluid helium confined in a narrow microchannel. We find that the field-current characteristics of the driven crystal obtained by the time-averaged measurements exhibit oscillations and negative differential conductivity. This unusual transport behavior was observed previously by Glasson et al. [Phys. Rev. Lett. 87, 176802 (2001)] and was attributed to a nonequilibrium transition of the electron system to a novel dynamically ordered phase of current filaments aligned along the channels. Contrarily to this explanation, our time-resolved transport measurements reveal that oscillating field-current characteristics appear due to dynamical decoupling (slipping) and recoupling (sticking) of the uniform electron crystal to the liquid helium substrate. Our result demonstrates that this unusual non-linear transport effect is intrinsic, does not depend on the device geometry, and is associated with the dynamical interaction of Wigner crystal with the surface excitations of the liquid substrate., Comment: 7 pages, 4 figures

Published
2021
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8. Diagnosis and management of pyruvate kinase deficiency: international expert guidelines

Author

Al-Samkari, Hanny, Shehata, Nadine, Lang-Robertson, Kelly, Bianchi, Paola, Glenthøj, Andreas, Sheth, Sujit, Neufeld, Ellis J, Rees, David C, Chonat, Satheesh, Kuo, Kevin H M, Rothman, Jennifer A, Barcellini, Wilma, van Beers, Eduard J, Pospíšilová, Dagmar, Shah, Ami J, van Wijk, Richard, Glader, Bertil, Mañú Pereira, Maria Del Mar, Andres, Oliver, Kalfa, Theodosia A, Eber, Stefan W, Gallagher, Patrick G, Kwiatkowski, Janet L, Galacteros, Frédéric, Lander, Carl, Watson, Alejandra, Elbard, Riyad, Peereboom, Dore, and Grace, Rachael F

Published
2024
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22. Defining global strategies to improve outcomes in sickle cell disease: a Lancet Haematology Commission

Author

Piel, Frédéric B, Rees, David C, DeBaun, Michael R, Nnodu, Obiageli, Ranque, Brigitte, Thompson, Alexis A, Ware, Russell E, Abboud, Miguel R, Abraham, Allistair, Ambrose, Emmanuela E, Andemariam, Biree, Colah, Roshan, Colombatti, Raffaella, Conran, Nicola, Costa, Fernando F, Cronin, Robert M, de Montalembert, Mariane, Elion, Jacques, Esrick, Erica, Greenway, Anthea L, Idris, Ibrahim M, Issom, David-Zacharie, Jain, Dipty, Jordan, Lori C, Kaplan, Zane S, King, Allison A, Lloyd-Puryear, Michele, Oppong, Samuel A, Sharma, Akshay, Sung, Lillian, Tshilolo, Leon, Wilkie, Diana J, and Ohene-Frempong, Kwaku

Published
2023
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30. A randomized, placebo-controlled, double-blind trial of canakinumab in children and young adults with sickle cell anemia

Author

Rees, David C., Kilinc, Yurdanur, Unal, Selma, Dampier, Carlton, Pace, Betty S., Kaya, Banu, Trompeter, Sara, Odame, Isaac, Mahlangu, Johnny, Unal, Sule, Brent, Julie, Grosse, Regine, Fuh, Beng R., Inusa, Baba P.D., Koren, Ariel, Leblebisatan, Goksel, Levin, Carina, McNamara, Elizabeth, Meiser, Karin, Hom, Douglas, and Oliver, Stephen J.

Published
2022
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31. Bistable Transport Properties of a Quasi-One-Dimensional Wigner Solid on Liquid Helium under Continuous Driving

Author

Rees, David G., Yeh, Sheng-Shiuan, Lee, Ban-Chen, Kono, Kimitoshi, and Lin, Juhn-Jong

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We investigate low-frequency fluctuations in the transport characteristics of a quasi-1D Wigner solid (WS) moving along a liquid helium substrate in response to a sinusoidal driving voltage. The fluctuations occur between distinct transport modes in which the decoupling of the WS from ripplonic polarons (or 'dimple lattice', DL) formed on the helium surface does, or does not, occur during each ac cycle. We demonstrate that a Gaussian-like distribution in the decoupling threshold force gives rise to this bistability, as the low-frequency switching occurs when the probability of decoupling during each ac cycle is small but finite. We attribute the distribution in the decoupling threshold force to the range of structural configurations allowed for the quasi-1D electron lattice, which influences the strength of the WS-DL coupling. Hence, the switching rate between the ac transport modes is extremely sensitive to the microscopic properties of the electron solid.

Published
2017
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34. Structural Order and Melting of a Quasi-One-Dimensional Electron System

Author

Rees, David G., Beysengulov, Niyaz R., Teranishi, Yoshiaki, Tsao, Chun-Shuo, Yeh, Sheng-Shiuan, Chiu, Shao-Pin, Lin, Yong-Han, Tayurskii, Dmitrii A., Lin, Juhn-Jong, and Kono, Kimitoshi

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We investigate the influence of confinement on the positional order of a quasi-1D electron system trapped on the surface of liquid helium. We find evidence that the melting of the Wigner solid (WS) depends on the confinement strength, as well as electron density and temperature. A reentrant solid-liquid-solid transition is observed for increasing electron density under constant electrostatic confinement. As the electron row number $N_y$ changes, varying commensurability results in a modulation of the WS order, even when $N_y$ is large (several tens). This is confirmed by Monte Carlo simulations.

Published
2016
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35. Stick-Slip Motion of the Wigner Solid on Liquid Helium

Author

Rees, David G., Beysengulov, Niyaz R., Lin, Juhn-Jong, and Kono, Kimitoshi

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Strongly Correlated Electrons
Abstract

We present time-resolved transport measurements of a Wigner solid (WS) on the surface of liquid Helium confined in a micron-scale channel. At rest, the WS is `dressed' by a cloud of quantised capillary waves (ripplons). Under a driving force, we find that repeated WS-ripplon decoupling leads to stick-slip current oscillations, the frequency of which can be tuned by adjusting the temperature, pressing electric field, or electron density. The WS on liquid He is a promising system for the study of polaron-like decoupling dynamics., Comment: 5 pages, 5 figures, and supplemental

Published
2016
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37. Impact of BCR::ABL1single nucleotide variants on asciminib efficacy

Author

Innes, Andrew J., Hayden, Chloe, Orovboni, Victoria, Claudiani, Simone, Fernando, Fiona, Khan, Afzal, Rees, David, Byrne, Jennifer, Gallipoli, Paolo, Francis, Sebastian, Copland, Mhairi, Horne, Gillian, Raghavan, Manoj, Arnold, Claire, Collins, Angela, Cranfield, Tanya, Cunningham, Nicholas, Danga, Akila, Forsyth, Peter, Frewin, Rebecca, Garland, Paula, Hannah, Guy, Avenoso, Daniele, Hassan, Sandra, Huntly, Brian J. P., Husain, Jissan, Makkuni, Sudhakaran, Rothwell, Kate, Khorashad, Jamshid, Apperley, Jane F., and Milojkovic, Dragana

Abstract

Asciminib is a potent and selective inhibitor of BCR::ABL1, with potential to avoid toxicity resulting from off-target kinase inhibition. Forty-nine patients treated with asciminib under a managed access program in the UK were evaluated for toxicity and response. Intolerance, rather than resistance (65% vs. 35%), was the most common reason for cessation of the last-line of treatment but asciminib was well tolerated, with most patients (29, 59%) remaining on treatment at a median of 14 months follow-up, and only 6 (12%) stopping for intolerance. Of 44 patients assessable for response, 29 (66%) achieved a complete cytogenetic response (CCyR) or better, with poorer responses seen in those stopping their last-line of therapy for resistance. Fewer patients with a prior history of a non-T315I-BCR::ABL1single nucleotide variant (BSNV), or a non-T315I-BSNV detectable at baseline achieved CCyR. Serial tracking of BSNV by next generation sequencing demonstrated clonal expansion of BSNV-harbouring populations, which in some settings was associated with resistance (E459K, F317L, F359I), while in others was seen in the context of ongoing response, often with intensified dosing (T315I, I502F). These data suggest that asciminib exerts selective pressure on some BSNV-harbouring populations in vivo, some of which may respond to intensified dosing.

Published
2024
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38. Diagnosis and management of pyruvate kinase deficiency: international expert guidelines

Author

Poli Van Creveldkliniek Medisch, Child Health, CDL Poli WKZ, CDL Cluster Speciële Diagnostiek, Circulatory Health, Al-Samkari, Hanny, Shehata, Nadine, Lang-Robertson, Kelly, Bianchi, Paola, Glenthøj, Andreas, Sheth, Sujit, Neufeld, Ellis J., Rees, David C., Chonat, Satheesh, Kuo, Kevin H.M., Rothman, Jennifer A., Barcellini, Wilma, van Beers, Eduard J., Pospíšilová, Dagmar, Shah, Ami J., van Wijk, Richard, Glader, Bertil, Mañú Pereira, Maria Del Mar, Andres, Oliver, Kalfa, Theodosia A., Eber, Stefan W., Gallagher, Patrick G., Kwiatkowski, Janet L., Galacteros, Frédéric, Lander, Carl, Watson, Alejandra, Elbard, Riyad, Peereboom, Dore, Grace, Rachael F., Poli Van Creveldkliniek Medisch, Child Health, CDL Poli WKZ, CDL Cluster Speciële Diagnostiek, Circulatory Health, Al-Samkari, Hanny, Shehata, Nadine, Lang-Robertson, Kelly, Bianchi, Paola, Glenthøj, Andreas, Sheth, Sujit, Neufeld, Ellis J., Rees, David C., Chonat, Satheesh, Kuo, Kevin H.M., Rothman, Jennifer A., Barcellini, Wilma, van Beers, Eduard J., Pospíšilová, Dagmar, Shah, Ami J., van Wijk, Richard, Glader, Bertil, Mañú Pereira, Maria Del Mar, Andres, Oliver, Kalfa, Theodosia A., Eber, Stefan W., Gallagher, Patrick G., Kwiatkowski, Janet L., Galacteros, Frédéric, Lander, Carl, Watson, Alejandra, Elbard, Riyad, Peereboom, Dore, and Grace, Rachael F.

Published
2024

39. Comparison of the scrape‐off layer two‐point model for deuterium and helium plasmas in JET ITER‐like wall low‐confinement plasma conditions.

Author

Rees, David, Sissonen, Joona, Groth, Mathias, Rikala, Vesa‐Pekka, Kumpulainen, Henri, Thomas, Beth, and Brix, Mathias

Subjects
*HELIUM plasmas, *PLASMA jets, *ION temperature, *DEUTERIUM plasma, *THOMSON scattering
Abstract

The hydrogenic two‐point model (H‐2PM), an analytical model for the scrape‐off layer that predicts a common electron and ion temperature and density along a flux tube from a target temperature and density, is adapted to a single‐species helium (He) model, preserving the 2PM assumptions and analytical nature. Across a range of densities and heating powers, the predicted Te$$ {T}_e $$ is within 20eV$$ 20\kern0.3em \mathrm{eV} $$ of upstream measurements by high‐resolution Thomson scattering (HRTS) for low‐confinement He plasmas performed in JET ITER‐like wall (JET‐ILW). For high‐recycling conditions, He‐2PM predictions of ne$$ {n}_e $$ were within 10% of the Li‐beam diagnostic measurements, excluding the near‐SOL, when assuming Zeff=1$$ {Z}_{\mathrm{eff}}=1 $$, suggesting the divertor SOL was not fully ionised in the JET‐ILW He plasmas. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Assessing The Potential for School Lunch Programme Ka Ora, Ka Ako to Enhance Education, Sustainability and Health Goals.

Author

McKelvie-Sebileau, Pippa, Swinburn, Boyd, Rees, David, Glassey, Rachael, Tipene-Leach, David, and Garton, Kelly

Subjects
SCHOOL food, GOVERNMENT policy, FOOD security
Abstract

The Ka Ora, Ka Ako school lunch programme introduced in 2020 provides nutritious lunches to around 220,000 students in low-advantage schools. While the food security impacts of this programme have been well documented, its potential to enhance outcomes in other areas of public policy is underappreciated. We conducted a policy analysis to map the programme's intersection with current public policy agendas in education, sustainability and health in Aotearoa New Zealand. We conclude that Ka Ora, Ka Ako can be a powerful platform to effect broad societal outcomes through alignment with school curricula, concerted effort to reduce carbon emissions, and commitment to delivering highly nutritious foods to all students in qualifying schools. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Upper and Lower Bounds to Pull-Out Loading of Inclined Hooked End Steel Fibres Embedded in Concrete.

Author

Rees, David W. A. and Abdallah, Sadoon

Subjects
SHEAR strength, TRANSVERSE strength (Structural engineering), FIBERS, STRUCTURAL design, STEEL
Abstract

Steel fibre-reinforced concrete (SFRC) consists of short, hooked steel fibres that are randomly distributed and oriented within the cementitious matrix. This paper presents a new analytical load-bounding approach that captures the tensile response of misaligned fibres embedded in the matrix. The contribution of fibres in bridging cracks to provide the required stress transfer relies on the orientation of the fibres in the concrete. Bridging fibres aligned with a crack are less effective than those inclined to it. Therefore, understanding the pull-out behaviour of misaligned fibres is a key factor in quantifying and optimising the design of SFRC in structural applications. In the laboratory, a single-oriented fibre embedded in a solid cylinder of concrete was subjected to a pull-out test, where the axis of the tensile force is aligned with the axis of the cylinder. Based on the observed behaviour, this paper presents a new analytical bounding approach to capture the pull-out response of misaligned hooked-end steel fibres embedded in a concrete matrix. The analysis was based on a transversely isotropic failure criterion assumed for the plasticity that occurs in the cold-drawn fibre. Lower and upper bounds to the loading failure were derived from fibre pull-out and fibre fracture, respectively. The division between bounds depended upon the fibre orientation, fibre diameter and the combined strengths of the steel and concrete. Bounding predictions were drawn from ratios between a fibre's shear strength and its transverse and axial uniaxial strengths, as found from a novel testing proposal. The two bounds were compared with new data and other experimental results published in the literature. The results showed that the region between the bounds captured the failure loads of embedded fibres with effective load-bearing orientations. A critical orientation was observed at maximum strength. The present interpretation of the plasticity occurring within off-axis, hooked-end steel fibres suggests that it is possible to optimise the strength of concrete using this method of reinforcement. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Comparison of OEDGE and EDGE2D‐EIRENE predictions of the scrape‐off layer conditions for attached plasmas.

Author

Rikala, Vesa‐Pekka, Groth, Mathias, Kumpulainen, Henri, and Rees, David

Subjects
ELECTRON temperature, ELECTRON density, ION temperature, COLLOIDS, FLUIDS
Abstract

Predictions of the scrape‐off layer (SOL) plasma conditions from the 2D multi‐fluid code EDGE2D‐EIRENE are compared to the OEDGE 1D fluid code for JET low‐confinement mode (L‐mode) plasmas. In the low‐recycling divertor conditions (divertor target plasma collisionality νe≈30$$ {\nu}_e\approx 30 $$), OEDGE and EDGE2D‐EIRENE agree on the electron temperature, the ion temperature, and the electron density within 10% in the low‐field side (LFS) divertor X‐point region (divertor SOL) and within 25% in the LFS midplane region. In high‐recycling conditions (νe≈55,000$$ {\nu}_e\approx 55,000 $$), the predictions of both codes agree on the electron temperature within 20%, while differences in the ion temperature and electron density increase to as high as 50% in the divertor SOL. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Will Suez shipping disruption derail hopes for rate cuts?

Author

Rees, David

Subjects
Shipping industry, Business, international
Abstract

Growing geopolitical tensions in the Middle East have begun to disrupt global supply chains. Following attacks by Houthi rebels on vessels passing through the Red Sea en route to the [...]

Published
2024

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