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3. Diagnostic findings in sinonasal aspergillosis in dogs in the United Kingdom: 475 cases (2011–2021).

Author

Prior, C., Swales, H., Sharman, M., Reed, N., Bommer, N., Kent, A., Glanemann, B., Clarke, K., Kortum, A., Kelly, D., Lea, C., Roberts, E., Rutherford, L., Tamborini, A., Murphy, K., Batchelor, D. J., Calleja, S., Burrow, R., Jamieson, P., and Best, M.

Subjects
INSPECTION & review, SYMPTOMS, FUNGAL cultures, ASPERGILLOSIS, PARANASAL sinuses
Abstract

Objectives: To describe the diagnostic tests used and their comparative performance in dogs diagnosed with sinonasal aspergillosis in the United Kingdom. A secondary objective was to describe the signalment, clinical findings and common clinicopathologic abnormalities in sinonasal aspergillosis. Materials and Methods: A multi‐centre retrospective survey was performed involving 23 referral centres in the United Kingdom to identify dogs diagnosed with sinonasal aspergillosis from January 2011 to December 2021. Dogs were included if fungal plaques were seen during rhinoscopy or if ancillary testing (via histopathology, culture, cytology, serology or PCR) was positive and other differential diagnoses were excluded. Results: A total of 662 cases were entered into the database across the 23 referral centres. Four hundred and seventy‐five cases met the study inclusion criteria. Of these, 419 dogs had fungal plaques and compatible clinical signs. Fungal plaques were not seen in 56 dogs with turbinate destruction that had compatible clinical signs and a positive ancillary test result. Ancillary diagnostics were performed in 312 of 419 (74%) dogs with observed fungal plaques permitting calculation of sensitivity of cytology as 67%, fungal culture 59%, histopathology 47% and PCR 71%. Clinical Significance: The sensitivities of ancillary diagnostics in this study were lower than previously reported challenging the clinical utility of such tests in sinonasal aspergillosis. Treatment and management decisions should be based on a combination of diagnostics including imaging findings, visual inspection, and ancillary testing, rather than ancillary tests alone. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Randomized Phase III Study Comparing Neoadjuvant Chemotherapy Followed by Surgery Versus Chemoradiation in Stage IB2-IIB Cervical Cancer: EORTC-55994

Author

Kenter, G, Greggi, S, Vergote, I, Katsaros, D, Kobierski, J, van Doorn, H, Landoni, F, van der Velden, J, Reed, N, Coens, C, van Luijk, I, Colombo, N, Steen-Banasik, E, Ottevanger, N, Casado, A, Kenter G. G., Greggi S., Vergote I., Katsaros D., Kobierski J., van Doorn H., Landoni F., van der Velden J., Reed N., Coens C., van Luijk I., Colombo N., Steen-Banasik E. v. d., Ottevanger N., Casado A., Kenter, G, Greggi, S, Vergote, I, Katsaros, D, Kobierski, J, van Doorn, H, Landoni, F, van der Velden, J, Reed, N, Coens, C, van Luijk, I, Colombo, N, Steen-Banasik, E, Ottevanger, N, Casado, A, Kenter G. G., Greggi S., Vergote I., Katsaros D., Kobierski J., van Doorn H., Landoni F., van der Velden J., Reed N., Coens C., van Luijk I., Colombo N., Steen-Banasik E. v. d., Ottevanger N., and Casado A.

Abstract

PURPOSE This multicenter trial by the European Organisation for Research and Treatment of Cancer Gynecological Cancer Group was motivated by conflicting evidence on the value of neoadjuvant chemotherapy before surgery compared with concomitant chemoradiotherapy (CCRT) in stage IB2-IIB cervical carcinoma.METHODSBetween May 2002 and January 2014, 626 patients with International Federation of Gynecology and Obstetrics stage IB2-IIb were randomly assigned between neoadjuvant chemotherapy followed by surgery (NACT-S; n = 314) and standard CCRT (n = 312). The primary end point was 5-year overall survival (OS) rate. Secondary end points were progression-free survival, OS, toxicity, and health-related quality of life (HRQOL).RESULTSAfter a median follow-up of 8.7 years, 198 patients (31.6%) died. Age, stage, and cell type were balanced in both arms. Protocol treatment was completed in 223 of 314 (71%) patients in NACT-S and 257 of 312(82%) in CCRT arms. Main reasons for incomplete protocol treatment were toxicity (30 of 314; 9.6%) and progressive disease (21 of 314; 6.7%) in the NACT-S arm and toxicity (23 of 312; 7.4%) and patient refusal (13 of 312; 4.2%) in the CCRT arm. Additional radiotherapy after completed NACT-S was given to 107 patients (48%), and additional surgery to 20 patients (8%) after completed CCRT. Short-term adverse events (AEs) â ‰¥grade 3 occurred more frequently with NACT-S (41% v 23%), and long-term AEs â ‰¥grade 3 more often with CCRT (21% v 15%). The 5-year OS was not significantly different between NACT-S (72%; 95% CI, 66 to 77) and CCRT (76%; 95% CI, 70 to 80).CONCLUSIONThis trial failed to demonstrate superiority in favor of the NACT-S arm but resulted in acceptable morbidity and HRQOL in both arms.

Published
2023

14. Randomized Phase III Study Comparing Neoadjuvant Chemotherapy Followed by Surgery Versus Chemoradiation in Stage IB2-IIB Cervical Cancer: EORTC-55994.

Author

Kenter, G.G., Greggi, S., Vergote, I., Katsaros, D., Kobierski, J., Doorn, H. van, Landoni, F., Velden, J. van der, Reed, N., Coens, C., Luijk, I. van, Colombo, N., Steen-Banasik, E.V., Ottevanger, N., Casado, A., Kenter, G.G., Greggi, S., Vergote, I., Katsaros, D., Kobierski, J., Doorn, H. van, Landoni, F., Velden, J. van der, Reed, N., Coens, C., Luijk, I. van, Colombo, N., Steen-Banasik, E.V., Ottevanger, N., and Casado, A.

Abstract

Item does not contain fulltext, PURPOSE: This multicenter trial by the European Organisation for Research and Treatment of Cancer Gynecological Cancer Group was motivated by conflicting evidence on the value of neoadjuvant chemotherapy before surgery compared with concomitant chemoradiotherapy (CCRT) in stage IB2-IIB cervical carcinoma. METHODS: Between May 2002 and January 2014, 626 patients with International Federation of Gynecology and Obstetrics stage IB2-IIb were randomly assigned between neoadjuvant chemotherapy followed by surgery (NACT-S; n = 314) and standard CCRT (n = 312). The primary end point was 5-year overall survival (OS) rate. Secondary end points were progression-free survival, OS, toxicity, and health-related quality of life (HRQOL). RESULTS: After a median follow-up of 8.7 years, 198 patients (31.6%) died. Age, stage, and cell type were balanced in both arms. Protocol treatment was completed in 223 of 314 (71%) patients in NACT-S and 257 of 312(82%) in CCRT arms. Main reasons for incomplete protocol treatment were toxicity (30 of 314; 9.6%) and progressive disease (21 of 314; 6.7%) in the NACT-S arm and toxicity (23 of 312; 7.4%) and patient refusal (13 of 312; 4.2%) in the CCRT arm. Additional radiotherapy after completed NACT-S was given to 107 patients (48%), and additional surgery to 20 patients (8%) after completed CCRT. Short-term adverse events (AEs) ≥grade 3 occurred more frequently with NACT-S (41% v 23%), and long-term AEs ≥grade 3 more often with CCRT (21% v 15%). The 5-year OS was not significantly different between NACT-S (72%; 95% CI, 66 to 77) and CCRT (76%; 95% CI, 70 to 80). CONCLUSION: This trial failed to demonstrate superiority in favor of the NACT-S arm but resulted in acceptable morbidity and HRQOL in both arms.

Published
2023

15. ESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer: diagnosis, treatment and follow-up

Author

Colombo, N., Creutzberg, C., Amant, F., Bosse, T., González-Martín, A., Ledermann, J., Marth, C., Nout, R., Querleu, D., Mirza, M.R., Sessa, C., Abal, M., Altundag, O., van Leeuwenhoek, Antoni, Banerjee, S., Casado, A., de Agustín, L.C., Cibula, D., del Campo, J.-M., Emons, G., Goffin, F., Greggi, S., Haie-Meder, C., Katsaros, D., Kesic, V., Kurzeder, C., Lax, S., Lécuru, F., Levy, T., Lorusso, D., Mäenpää, J., Matias-Guiu, X., Morice, P., Nijman, H.W., Powell, M., Reed, N., Rodolakis, A., Salvesen, H., Sehouli, J., Taylor, A., Westermann, A., and Zeimet, A.G.

Published
2016
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20. Cultural Weed Management Strategies in Flooded Rice: Effects of Rice Cultivar and Drill Row Width on Barnyardgrass [Echinochloa crus-galli (L.) P. Beauv.].

Author

Reed, N. H., Butts, T. R., Norsworthy, J. K., Hardke, J. T., Barber, L. T., Bond, J. A., Bowman, H. D., Davis, B. M., Dillon, T. W., and Kouame, K. B. J.

Subjects
WEEDS, WEED control, ECHINOCHLOA, RICE, HERBICIDE resistance, SMALL farms, CULTIVARS
Abstract

In a flooded Arkansas rice system, producers and consultants identified the most problematic weed they face is barnyardgrass [Echinochloa crus-galli (L.) P. Beauv.]. Due to the evolution of herbicide resistance and the overall hardiness of the weed, other control measures are needed for barnyardgrass in rice. The objective of this study was to evaluate the influence of rice cultivars and the manipulation of drill row width for barnyardgrass control in rice. Field experiments were conducted at the University of Arkansas System Division of Agriculture's Pine Bluff Small Farm Outreach Center, near Lonoke, Arkansas, Pine Tree Research Station, near Colt, Arkansas, and the Rohwer Research Station, near Watson, Arkansas in 2021 and 2022. The experiments were designed as randomized complete block split-plot designs (16 treatments) replicated 4 times with 4 nontreated controls for each drill width spacing. Each trial consisted of a whole plot factor of 4 drill row width spacings: 5, 7.5, 10, and 15 in. The subplot factor consisted of 4 cultivars: medium-grain inbred (CLM04), long-grain inbred (CLL16), long-grain hybrid (RT 7301), and FullPage long-grain hybrid (RT 7521 FP). Results indicated no interaction of drill row width spacing and rice cultivar for any response variables. A decrease in barnyardgrass density was observed for the 7.5-in. spacing compared to the 15-in. spacing across site-years for the 5- to 6-leaf (preflood) and preharvest rice stages. A 43% decrease in barnyardgrass density was observed for the hybrid cultivars compared to the inbred at the preharvest timing. Based on small unmanned aerial system (sUAS) imagery at panicle differentiation, there was a 20 percentage point decrease in canopy coverage from the 7.5 in. drill row width to the 15 in. width. This research provides insights on alternative weed management efforts through more precise drill row width spacing and cultivar selection in an Arkansas flooded rice system. [ABSTRACT FROM AUTHOR]

Published
2023

21. Herbicide-Coated Urea Efficacy in United States Mid-South Rice.

Author

Kouame, K. B. J., Butts, T. R., Davis, B. M., Collie, L. M., Dillon, T. W., Reed, N. H., Norsworthy, J. K., and Barber, L. T.

Subjects
WEEDS, UREA, YELLOW nutsedge, WEED control, HERBICIDES, RICE, SESBANIA
Abstract

Field experiments were conducted in 2022 at the University of Arkansas Pine Bluff Small Farm Outreach Center near Lonoke, Ark., to evaluate the impact of coating fertilizer with herbicides on weed control efficacy. The first study used three herbicide programs [florpyrauxifen-benzyl (Loyant), a premixture of florpyrauxifen-benzyl + penoxsulam (Novixid), and a mixture of halosulfuron (Permit) + florpyrauxifen-benzyl (Loyant)] applied either as directly coated on urea or as a foliar spray application following urea application, leading to a total of six treatments. Urea (46%), Loyant, Novixid, and Permit were applied at 68.96, 0.03, 0.06, and 0.01 lb ai/ac, respectively. A nontreated control that received an application of urea was also included for weed control evaluation purposes. In a second study, the effect of coating urea with the 4-hydroxyphenylpyruvate dioxygenase-(HPPD-) inhibiting herbicide benzobicyclon (Rogue) was evaluated for weed control. Benzobicyclon sprayed versus coated on urea was applied preflood, flood or post-flood (2 weeks after flood treatment) at 0.34 lb ai/ac. In the first study, barnyardgrass [Echinochloa crus-galli (L.) P. Beauv.], rice flatsedge (Cyperus iria L.), and yellow nutsedge (Cyperus esculentus L.) control were affected by treatments at 7, 14, and 22 days after application (DAA), while hemp sesbania [Sesbania herbacea (Mill.) McVaugh] control was affected only at 7 DAA. In most cases, Novixid sprayed foliarly and Novixid-coated urea provided near similar levels of control of barnyardgrass, rice flatsedge, yellow nutsedge, and hemp sesbania. In the second study, hemp sesbania and sprangletop (Diplachne spp) control were numerically improved with Rogue applied at flood compared to the other application timings. Also, Rogue-coated on urea at flood provided numerically greater control of both weeds, 15 and 29 days after flood, than did the herbicide when sprayed. As a result, Novixid-coated and Rogue-coated fertilizers may be viable options to maintain high levels of weed control on some of the most problematic Arkansas rice weeds while mitigating off-target herbicide movement. [ABSTRACT FROM AUTHOR]

Published
2023

22. Bed Width and Drill Spacing Effect on Weed Management in Furrow-Irrigated Rice.

Author

Davis, B. M., Butts, T. R., Reed, N. H., Barber, L. T., Norsworthy, J. K., Hardke, J. T., Bond, J. A., Bowman, H. D., and Kouame, K. B-J.

Subjects
WEED control, RICE, HYBRID rice, WEEDS, FARMERS, DIGITAL images, HERBICIDES
Abstract

Furrow-irrigated rice (Oryza sativa L.), or row rice, has increased in acreage in Arkansas in the past few years. This practice allows growers to potentially grow rice on steeper ground that would require a vast number of levees that is labor and time intensive. However, this non-traditional rice growing method has a weed management drawback. The removal of the flood as a means of weed control places additional pressure on other weed management strategies and potentially different herbicide programs. Therefore, the objectives of this research were to determine if the manipulation of drill row spacing and bed width would influence season-long weed control. Two studies were seeded with hybrid rice RT7521 FP in 2021 and 2022 at Lonoke and Pine Tree, Ark. to evaluate treatments that consisted of three bed widths (30-, 38-, and 60-in.) and four drill row spacings (5-, 7.5-, 10-, and 15-in.). Barnyardgrass [Echinochloa crus galli (L.) P. Beauv.] density was assessed at the 5- to 6-leaf rice stage and preharvest. Canopy closure was captured with aerial digital images from a small, unmanned aircraft system (sUAS) collected at the 3-6 leaf and panicle differentiation rice stages. Rough rice yield was harvested with a plot combine and adjusted to 13% moisture. In general, barnyardgrass densities were lower across narrower drill row spacings (=7.5-in.) and bed widths (30-in.) early in the season; however, little differences were seen at the later preharvest timing. Canopy closure responded similarly as narrower drill row spacing and bed width had greater canopy closure. Rough rice yield was impacted less by drill row spacing and bed width, but narrower drill row spacing and bed width had a slightly higher numerical yield increase. Early findings suggest that a grower choosing this method of rice management should choose the narrowest drill row spacing allowed by their equipment and the narrowest bed widths that they can obtain to maximize weed management efforts. [ABSTRACT FROM AUTHOR]

Published
2023

23. Outcomes for transplant-eligible, newly diagnosed Black patients (Pts) with multiple myeloma (MM): The Levine Cancer Institute (LCI) experience.

Author

Paul, Barry, primary, Atrash, Shebli, additional, Robinson, Myra M., additional, Jagosky, Megan, additional, Bhutani, Manisha, additional, Varga, Cindy, additional, Pineda-Roman, Mauricio, additional, Friend, Reed N., additional, Foureau, David, additional, Cassetta, Kristen, additional, Usmani, Saad Zafar, additional, and Voorhees, Peter M., additional

Published
2022
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24. ENETS standardized (synoptic) reporting for endoscopy in neuroendocrine tumors

Author

Borbath, I., Pape, U. -F., Deprez, P. H., Bartsch, D. K., Caplin, M., Falconi, M., Garcia-Carbonero, R., Grozinsky-Glasberg, S., Jensen, R. T., Arnold, R., Ruszniewski, P., Toumpanakis, C., Valle, J. W., O'Toole, D., Belli, S. H., Castano, J. P., Chen, J., Costa, F. P., Couvelard, A., de Herder, W. W., Deroose, C. M., Dromain, C., Faggiano, A., Falkerby, J., Fazio, N., Frilling, A., Grande, E., Hand, P., Hicks, R. J., Horsch, D., Howe, J. R., Kloppel, G., Kolarova, T., Kos-Kudla, B., Koumarianou, A., Krejs, G. J., Krenning, E. P., Krishna, B. A., Leyden, S., Masui, T., Niederle, B., Nieveen van Dijkum, E. J., Oberg, K., Pavel, M., Perren, A., Prasad, V., Ramage, J. K., Reed, N. S., Rindi, G., Gemelli, A., Rinke, A., Rothmund, M., Singh, S., Sundin, A., Velthuysen, M. F. V., Verslype, C., Vullierme, M. P., Welin, S., Wiedenmann, B., Zhao, H., Graduate School, Surgery, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de gastro-entérologie, and UCL - (SLuc) Unité d'oncologie médicale

Subjects
Cellular and Molecular Neuroscience, Neuroendocrine Tumors, Endocrinology, neuroendocrine neoplasms, Endocrine and Autonomic Systems, Endocrinology, Diabetes and Metabolism, Humans, Endoscopy, endoscopy, standardised reporting
Abstract

Despite efforts from various endoscopy societies, reporting in the field of endoscopy remains extremely heterogeneous. Harmonisation of clinical practice in endoscopy has been highlighted by application of many clinical practice guidelines and standards pertaining to the endoscopic procedures and reporting are underlined. The aim of the proposed "standardised reporting" is to (1) facilitate recognition of gastrointestinal neuroendocrine neoplasms (NEN) on initial endoscopy, (2) to enable interdisciplinary decision making for treatment by a multidisciplinary team, (3) to provide a basis for a standardised endoscopic follow-up which allows detection of recurrence or progression reliably, (4) to make endoscopic reports on NEN comparable between different units, and (5) to allow research collaboration between NEN centres in terms of consistency of their endoscopic data. The ultimate goal is to improve disease management, patient outcome and reduce the diagnostic burden on the side of the patient by ensuring the highest possible diagnostic accuracy and validity of endoscopic exams and possibly interventions.

Published
2022

27. Unmet Needs in Appendiceal Neuroendocrine Neoplasms

Author

Toumpanakis, C, Fazio, N, Janson, ET, Horsch, D, Pascher, A, Reed, N, O'Toole, D, van Dijkum, EN, Partelli, S, Rinke, A, Kos-Kudla, B, Costa, F, Pape, UF, Grozinsky-Glasberg, S, Scoazec, JY, Detlef, B, Rudolf, A, Eric, B, Lisa, B, Ivan, B, Jaume, C, Martyn, C, Jie, C, Frederico, C, Anne, C, Jaroslaw, BC, de Herder, W.W., Massimo, F, Jenny, F, Nicola, F, Diego, F, Andrea, F, Rocio, GC, Simona, G, Vera, G, Ashley, G, Dieter, H, Robert, J, Gregory, K, Gunter, K, Peter, KU, Beata, KK, Guenter, JK, Krenning, EP, Matthew, K, Steven, WJL, Elisabeth, NV, Manuel, OJ, Dermot, O, Ulrich-Frank, P, Di Stefano, P, Ellen, PM, Marc, P, John, R, Nicholas, R, Guido, R, Anja, R, Philippe, R, Halfdan, S, Anders, S, Jean-Yves, S, Babs, GT, Eva, TJ, Christos, T, Juan, V, Marie-Pierre, V, Staffan, W, Bertram, W, Internal Medicine, ENETS 2016 Munich Advisory Board, Toumpanakis, C., Fazio, N., Tiensuu Janson, E., Horsch, D., Pascher, A., Reed, N., O'Apostoole, D., Nieveen Van Dijkum, E., Partelli, S., Rinke, A., Kos-Kudla, B., Costa, F., Pape, U. -F., Grozinsky-Glasberg, S., and Scoazec, J. -Y.

Subjects
medicine.medical_specialty, Biomedical Research, Critical approach, Neuroendocrine Tumors/diagnosis, Endocrinology, Diabetes and Metabolism, Guidelines as Topic, 030209 endocrinology & metabolism, Aggressive disease, Appendix, 030218 nuclear medicine & medical imaging, Unmet needs, Biomedical Research/trends, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Endocrinology, Internal medicine, Epidemiology, medicine, Humans, Intensive care medicine, Appendiceal neuroendocrine neoplasm, Appendiceal Neoplasms/diagnosis, Endocrine and Autonomic Systems, business.industry, Clinical course, Right hemicolectomy, Retrospective cohort study, Prognosis, Carcinoid, Neuroendocrine tumour, Neuroendocrine Tumors, Appendiceal Neoplasms, Human medicine, Appendicectomy, business
Abstract

Appendiceal neuroendocrine neoplasms (ANEN) are mostly discovered coincidentally during appendicectomy and usually have a benign clinical course; thus, appendicectomy alone is considered curative. However, in some cases, a malignant potential is suspected, and therefore additional operations such as completion right hemicolectomy are considered. The existing European Neuroendocrine Tumour Society (ENETS) guidelines provide useful data about epidemiology and prognosis, as well as practical recommendations with regards to the risk factors for a more aggressive disease course and the indications for a secondary operation. However, these guidelines are based on heterogeneous and retrospective studies. Therefore, the evidence does not seem to be robust, and there are still unmet needs in terms of accurate epidemiology and overall prognosis, optimal diagnostic and follow-up strategy, as well as identified risk factors that would indicate a more aggressive surgical approach at the beginning and a more intense follow-up. In this review, we are adopting a critical approach of the ENETS guidelines and published series for ANEN, focusing on the above-noted “grey areas”.

Published
2019

29. Additional file 1 of The effect of missing data and imputation on the detection of bias in cognitive testing using differential item functioning methods

Author

Nichols, E., Deal, J. A., Swenor, B. K., Abraham, A. G., Armstrong, N. M., Bandeen-Roche, K., Carlson, M. C., Griswold, M., Lin, F. R., Mosley, T. H., Ramulu, P. Y., Reed, N. S., Sharrett, A. R., and Gross, A. L.

Abstract

Additional file 1: Supplementary Figure. Absolute value of the median error in DIF estimates due to missingnessrelated to cognitive test performance for hearing impairment, black race andmoderate to low education in the Atherosclerosis Risk in CommunitiesNeurocognitive Study (ARIC-NCS). Estimates are shown for scenarios with noimputation, hotdeck single imputation, Single Imputation by Chained Equations(SICE) and Multiple Imputation by Chained Equations (MICE).

Published
2022
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30. The Use of Fall Residuals for Ryegrass Management Ahead of Soybean.

Author

Reed, N. H., Butts, T. R., Norsworthy, J. K., Barber, L. T., Burgos, N. R., Davis, B. M., Dillon, T. W., Collie, L. M., and Kouame, K. B. J.

Subjects
WEEDS, ITALIAN ryegrass, RYEGRASSES, HERBICIDE resistance, LOLIUM perenne, SOYBEAN, HERBICIDES
Abstract

Italian ryegrass [Lolium perenne L. ssp. multiflorum (Lam.) Husnot] has become more problematic and difficult to control because it is resistant to multiple herbicides. Fall-applied residual herbicides have effectively controlled other winter annual weeds and could be another option in controlling Italian ryegrass. The objective of this study was to evaluate multiple residual herbicides for the control of Italian ryegrass in the fall and the following spring before planting soybean [Glycine max (L.) Merr.]. Before any weed emergence, a field experiment was initiated at the University of Arkansas System Division of Agriculture's Jackson County Extension Center near Newport, Ark., in the fall of 2021. Treatments in this experiment consisted of Anthem® Flex (4 fl oz/ac), Command® (20 fl oz/ac), Dual Magnum® (1.33 pt/ac), Outlook® (16 fl oz/ac), Prowl® (2.1 pt/ac), Treflan® (2 pt/ac), Warrant® (2.5 pt/ac), Warrant® (5 pt/ac), and Zidua® SC (3.75 fl oz/ac). Initial visual control of Italian ryegrass 14 days after application (DAA) (28 Oct. 2021) exceeded 95% for every herbicide treatment except for Prowl and the low rate of Warrant. Only Zidua SC, Anthem Flex, and Dual Magnum retained effective residual control at 60 DAA (13 Dec. 2021) (>95%) and 166 DAA (29 March 2022) (>90%). Overall, using Zidua SC, Anthem Flex, and Dual Magnum herbicides were the most effective options to control Italian ryegrass in the fall and following spring before planting soybean. These fall-applied treatments would improve overall Italian ryegrass management and delay the evolution of resistance to postemergence herbicides. [ABSTRACT FROM AUTHOR]

Published
2023

35. The effects of a home-based exercise intervention versus group exercise on fatigue and functional endurance in men with prostate cancer on androgen deprivation therapy: A non-inferiority randomized controlled trial

Author

Papadopoulos, E., primary, Santa Mina, D., additional, Ritvo, P., additional, Tomlinson, G., additional, Sabiston, C., additional, Krahn, M., additional, Durbano, S., additional, Chiarotto, J., additional, Matthew, A., additional, Warde, P., additional, O’Neill, M., additional, Culos-Reed, N., additional, and Alibhai, S., additional

Published
2021
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41. An international, phase III randomized trial in patients with mucinous epithelial ovarian cancer (mEOC/GOG 0241) with long-term follow-up: and experience of conducting a clinical trial in a rare gynecological tumor

Author

Gore, M, Hackshaw, A, Brady, WE, Penson, RT, Zaino, R, McCluggage, WG, Ganesan, R, Wilkinson, N, Perren, T, Montes, A, Summers, J, Lord, R, Dark, G, Rustin, G, Mackean, M, Reed, N, Kehoe, S, Frumovitz, M, Christensen, H, Feeney, A, Ledermann, J, and Gershenson, DM

Subjects
Adult, Internationality, Paclitaxel, Carcinoma, Ovarian Epithelial, Article, Carboplatin, Young Adult, Antineoplastic Combined Chemotherapy Protocols, Chemotherapy, Humans, Factorial design, Rare tumor trial, Capecitabine, Response Evaluation Criteria in Solid Tumors, Aged, Aged, 80 and over, Ovarian Neoplasms, Mucinous ovarian cancer, Middle Aged, Progression-Free Survival, Bevacizumab, Oxaliplatin, Survival Rate, Quality of Life, Female, Neoplasm Recurrence, Local, Neoplasms, Cystic, Mucinous, and Serous, Follow-Up Studies
Abstract

Objectives We evaluated four different treatment regimens for advanced-stage mucinous epithelial ovarian cancer. Methods We conducted a multicenter randomized factorial trial (UK and US). Patients were diagnosed with primary mEOC: FIGO stage II–IV or recurrence after stage I disease. Treatment arms were paclitaxel-carboplatin, oxaliplatin-capecitabine, paclitaxel-carboplatin-bevacizumab, or oxaliplatin-capecitabine-bevacizumab. Chemotherapy was given 3-weekly for 6 cycles, and bevacizumab (3-weekly) was continued as maintenance (for 12 cycles). Endpoints included overall-survival (OS), progression-free survival (PFS), toxicity and quality of life (QoL). Results The trial stopped after 50 patients were recruited due to slow accrual. Median follow-up was 59 months. OS hazard ratios (HR) for the two main comparisons were: 0.78 (p = 0.48) for Oxal-Cape vs. Pac-Carbo (each with/without bevacizumab), and 1.04 (p = 0.92) for bevacizumab vs. no bevacizumab. Corresponding PFS HRs were: 0.84 and 0.80. Retrospective central pathology review revealed only 45% (18/40) cases with available material had confirmed primary mEOC. Among these, OS HR for Oxal-Cape vs. Pac-Carbo was 0.36 (p = 0.14); PFS HR = 0.62 (p = 0.40). Grade 3–4 toxicity was seen in 61% Pac-Carbo, 61% Oxal-Cape, 54% Pac-Carbo-Bev, and 85% Oxal-Cape-Bev. QoL was similar between the four arms. Conclusion mEOC/GOG0241 represents an example of a randomized rare tumor trial. Logistical challenges led to early termination, including difficulties in local histopathological diagnosis and accessing drugs outside their labelled indication. There was misalignment between central funders who support clinical trials in rare cancers and the deprioritisation of such work by those managing and funding research at a local level. Rare cancer trials should include centralised pathology review before treatment. Clinical trial registry number: ISRCTN83438782., Highlights • mEOC/GOG-0241 is one of the first international rare tumor trials. • Oxaliplatin/capecitabine might be worth further study. Long-term follow-up is feasible in rare tumors. • Challenges were lack of local resources and funding for experimental licenced therapies.

Published
2019

45. Loss of TDP-43 function and rimmed vacuoles persist after T cell depletion in a xenograft model of sporadic inclusion body myositis

Author

Kerstin E. Braunstein, Russel Ka, Kathryn R. Wagner, Iago Pinal-Fernandez, Andrea M. Corse, Philip C. Wong, Jonathan P. Ling, Andrew L. Mammen, Reed N, Tsao W, Larman Hb, Ashley M. Wilson, Kastenschmidt Jm, Britson Ka, S. A. Villalta, Thomas E. Lloyd, Janelle Montagne, Ikenaga C, and Lyle W. Ostrow

Subjects
Pathology, medicine.medical_specialty, biology, Rimmed vacuoles, Skeletal muscle, Inflammation, Major histocompatibility complex, Exon, medicine.anatomical_structure, Downregulation and upregulation, medicine, biology.protein, Myocyte, medicine.symptom, CD8
Abstract

Sporadic inclusion body myositis (IBM) is the most common acquired muscle disease in adults over age 50, yet it remains unclear whether the disease is primarily driven by T cell-mediated autoimmunity. IBM muscle biopsies exhibit nuclear clearance and cytoplasmic aggregation of TDP-43 in muscle cells, a pathologic finding observed initially in neurodegenerative disease, and nuclear loss of TDP-43 in neurons causes aberrant RNA splicing. Here, we show that loss of TDP-43 splicing repression, as determined by inclusion of cryptic exons, occurs in skeletal muscle of IBM patients. Out of 119 muscle biopsies tested, RT-PCR-mediated detection of cryptic exon expression is 84% sensitive and 99% specific for diagnosing IBM, indicating utility as a functional and diagnostic biomarker. To determine the role of T cells in pathogenesis, we generated a novel xenograft model by transplanting human IBM muscle into the hindlimb of immunodeficient mice. Xenografts from IBM patients display robust regeneration of human myofibers and recapitulate both inflammatory and degenerative features of the disease. Myofibers in IBM xenografts are invaded by human, oligoclonal CD8+ T cells and exhibit MHC-I upregulation, rimmed vacuoles, mitochondrial pathology, p62-positive inclusions, and nuclear clearance and cytoplasmic aggregation of TDP-43, resulting in expression of cryptic exons. Depletion of human T cells within IBM xenografts by treating mice intraperitoneally with anti-CD3 (OKT3) suppresses MHC-I upregulation, but rimmed vacuoles and loss of TDP-43 function persist. These data suggest that myofiber degeneration occurs independent of T cells, and muscle cell-intrinsic mechanisms, such as loss of TDP-43 splicing repression, drive IBM pathogenesis.One Sentence SummaryDepletion of T cells in a xenograft model of sporadic inclusion body myositis suppresses inflammation but not TDP-43 pathology or muscle degeneration.

Published
2021

46. Psychological, psychophysiological and behavioural effects of participant-selected vs. researcher-selected music in simulated urban driving

Author

Karageorghis, C, Mouchlianitis, E, Payre, W, Kuan, G, Howard, L, Reed, N, and Parkes, A

Subjects
Adult, Male, Automobile Driving, media_common.quotation_subject, Applied psychology, Emotions, Physical Therapy, Sports Therapy and Rehabilitation, Human Factors and Ergonomics, Affect (psychology), Arousal, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Distraction, Personality, Humans, 0501 psychology and cognitive sciences, Safety, Risk, Reliability and Quality, Engineering (miscellaneous), 050107 human factors, media_common, 05 social sciences, Affective valence, simulation, 030210 environmental & occupational health, Mental demand, affect, personality, young drivers, Psychological aspects, Psychology, road safety, distraction, Music, Psychophysiology
Abstract

Copyright © 2021 The Author(s). We investigated the effect of participant-selected (PSel) and researcher-selected (RSel) music on urban driving behaviour in young men (N = 27; Mage = 20.6 years, SD = 1.9 years). A counterbalanced, within-subjects design was used with four simulated driving conditions: PSel fast-tempo music, PSel slow-tempo music, RSel music and an urban traffic-noise control. The between-subjects variable of personality (introverts vs. extroverts) was explored. The presence of PSel slow-tempo music and RSel music optimised affective valence and arousal for urban driving. NASA Task Load Index scores indicated that the urban traffic-noise control increased mental demand compared to PSel slow-tempo music. In the PSel slow-tempo condition, less use was made of the brake pedal. When compared to extroverts, introverts recorded lower mean speed and attracted lower risk ratings under PSel slow-tempo music. The utility of PSel slow-tempo and RSel music was demonstrated in terms of optimising affective state for simulated urban driving. UKRI Economic and Social Research Council grant awarded to the first and last authors (ES/R005559/1). The study was also supported by a research grant from the Direct Line Group (UK)

Published
2021

49. Weedy Rice Control When Using Single and Sequential Applications of Oxyfluorfen.

Author

Arnold, C. H., Norsworthy, J. K., Pritchett, S. L., Reed, N. H., Butts, T. R., and Barber, L. T.

Subjects
OXYFLUORFEN, HERBICIDE resistance, HERBICIDE application, RICE, WEED science, HERBICIDES
Abstract

Weedy rice in Arkansas is resistant to HRAC/WSSA group 1 and 2 herbicides that are commonly used for control. The ROXY® Rice Production System (RRPS) provides tolerance to herbicides containing oxyfluorfen. Oxyfluorfen is a Herbicide Resistance Action Committee/Weed Science Society of America (HRAC/WSSA) group 14 herbicide labeled for preemergence (PRE) and postemergence (POST) applications in many crops. Oxyfluorfen currently is not labeled for use in rice; however, the Roxy trait in the RRPS allows for applications of the herbicide. During the 2021 and 2022 growing seasons, two independent field trials were conducted at the University of Arkansas System Division of Agriculture's Rice Research and Extension Center near Stuttgart, Ark. The first experiment was designed to determine if there was a rate response for weedy rice control associated with oxyfluorfen applied POST at the 2-leaf growth stage of weedy rice. The second experiment was designed to determine the optimal rate of oxyfluorfen to use PRE and POST in a sequential program when the maximum annual rate could not exceed 1.5 lb ai/ac. For the rate response experiment, oxyfluorfen (ALB2024) was POST-applied at 0.5, 0.75, 1, 1.25, or 1.5 lb ai/ac when the weedy rice reached the 2-leaf growth stage. In the sequential application experiment, mixtures of clomazone and oxyfluorfen (ALB2023) (0.3 plus 0.5, 0.75, or 1 lb ai/ac, respectively) were applied PRE, followed by a POST application of oxyfluorfen that resulted in the total amount of the herbicide applied being 1.5 lb ai/ac. Weedy rice control for all treatments ranged from 57 to 73% for the rate response experiment at 35 days after treatment. In the sequential application experiment, oxyfluorfen applied PRE resulted in 46 and 70% weedy rice control at the lowest (0.5 lb ai/ac) and highest (1 lb ai/ac) oxyfluorfen rates, respectively. At 14 days after the final treatment, 78 to 81% weedy rice control was observed for all treatments when oxyfluorfen was applied sequentially. Oxyfluorfen could potentially serve to suppress weedy rice in a RRPS; however, oxyfluorfen alone will not be able to achieve complete control. [ABSTRACT FROM AUTHOR]

Published
2023

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