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3. CREST: phase III study of sasanlimab and Bacillus Calmette-Guérin for patients with Bacillus Calmette-Guérin-naïve high-risk non-muscle-invasive bladder cancer

Author

Steinberg, Gary D, primary, Shore, Neal D, additional, Redorta, Joan Palou, additional, Galsky, Matthew D, additional, Bedke, Jens, additional, Ku, Ja Hyeon, additional, Kretkowski, Michal, additional, Hu, Hailong, additional, Penkov, Konstantin, additional, Vermette, Jennifer J, additional, Tarazi, Jamal C, additional, Randall, Alison E, additional, Pierce, Kristen J, additional, Saltzstein, Daniel, additional, and Powles, Thomas B, additional

Published
2024
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4. Outcomes of Intracorporeal Urinary Diversion after Robot-Assisted Radical Cystectomy: Results from the International Robotic Cystectomy Consortium

Author

Wagner, Andrew, Saar, Matthias, Stockle, Michael, Redorta, Joan Palou, Richstone, Lee, Badani, Ketan, Scherr, Douglas, Khan, Hijab, Gaboardi, Franco, Rha, Koon-Ho, Kawa, Omar, Tan, Wei Shen, Schanne, Francis, Polakis, Vassilis, Weizer, Alon, Maatman, Thomas J., Pini, Giovannalberto, Peak, Taylor C., Kibel, Adam, Yuh, Bertram, Hussein, Ahmed A., May, Paul R., Jing, Zhe, Ahmed, Youssef E., Wijburg, Carl J., Canda, Abdulla Erdem, Dasgupta, Prokar, Shamim Khan, Mohammad, Menon, Mani, Peabody, James O., Hosseini, Abolfazl, Kelly, John, Mottrie, Alexandre, Kaouk, Jihad, Hemal, Ashok, Wiklund, Peter, and Guru, Khurshid A.

Published
2018
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6. Quality of surgical care can impact survival in patients with bladder cancer after robot-assisted radical cystectomy: results from the International Robotic Cystectomy Consortium

Author

Ahmed, Youssef, Hussein, Ahmed A., May, Paul R., Ahmad, Basel, Khan, Amir, Benkowski, John, Durrani, Ayesha, Khan, Saira, Kozlowski, Justen, Saar, Matthias, Wijburg, Carl J., Richstone, Lee, Wagner, Andrew, Yuh, Bertram, Redorta, Joan Palou, Dasgupta, Prokar, Khan, Mohammad Shamim, Menon, Mani, Peabody, James O., Hosseini, Abolfazl, Gaboardi, Franco, Pini, Giovannalberto, Schanne, Francis, Mottrie, Alexandre, Rha, Koon-ho, Hemal, Ashok, Stockle, Michael, Kelly, John, Tan, Wei Shen, Maatman, Thomas J., Poulakis, Vassilis, Kaouk, Jihad, Canda, Abdullah Erdem, Balbay, Mevlana Derya, Wiklund, Peter, and Guru, Khurshid A.

Published
2020
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7. PD21-06 ONCOLOGICAL OUTCOMES IN IMMUNOCOMPROMISED VS IMMUNOCOMPETENT PROSTATE CANCER PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS

Author

Sanguedolce, Francesco, primary, Tedde, Alessandro, additional, Baboudjian, Michael, additional, Uleri, Alessandro, additional, Verri, Paolo, additional, Basile, Giuseppe, additional, Gallioli, Andrea, additional, Territo, Angelo, additional, Suquilanda Piedra, Edgar Cristian, additional, Robalino Aldaz, Jorge Miguel, additional, Pérez, Jordi Huguet, additional, Gaya Sopena, Josep Maria, additional, Madonia, Massimo, additional, Redorta, Joan Palou, additional, and Breda, Alberto, additional

Published
2023
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8. A Multicenter Study of 2-year Outcomes Following Hyperthermia Therapy with Mitomycin C in Treating Non-Muscle Invasive Bladder Cancer: HIVEC-E

Author

Tan, Wei Phin, primary, Plata Bello, Ana, additional, Garcia Alvarez, Carlos, additional, Guerrero-Ramos, Félix, additional, González-Padilla, Daniel A., additional, Nzeh, Cajetan, additional, Manuel de la Morena, Jose, additional, de Torres, Ignacio Gonzalez Valcarcel, additional, Hendricksen, Kees, additional, Díaz Goizueta, Francisco Javier, additional, Del Álamo, Julio Fernandez, additional, Chiancone, Francesco, additional, Fedelini, Paolo, additional, Poggio, Massimiliano, additional, Porpiglia, Francesco, additional, Gonzalo Rodríguez, Victoria C., additional, Torres, Javier Montero, additional, Wilby, Daniel, additional, Robinson, Richard, additional, Sousa-Escandón, Alejandro, additional, Mata, Juan León, additional, Pontones Moreno, Jose L., additional, Molina, Francisco Delgados, additional, Adriazola Semino, Miguel A., additional, Stemberger, Andrew T., additional, Escudero, Jesús Calleja, additional, Redorta, Joan Palou, additional, and Tan, Wei Shen, additional

Published
2022
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9. How do endoscopic bladder tumor resection techniques affect pathology practice? EAU Section of Uro-Technology (ESUT) and Uropathology (ESUP) survey

Author

Guven, Selcuk, primary, Colecchia, Maurizio, additional, Oltulu, Pembe, additional, Bonfante, Giulia, additional, Enikeev, Dmitry, additional, Esen, Hasan, additional, Herrmann, Thomas, additional, Lusuardi, Lukas, additional, Micali, Salvatore, additional, Somani, Bashkar, additional, Skolarikos, Andreas, additional, Breda, Alberto, additional, Liatsikos, Evangelos, additional, Redorta, Joan Palou, additional, and Gozen, Ali Serdar, additional

Published
2022
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10. MP54-15 A MULTICENTER STUDY OF 2-YEAR OUTCOMES FOLLOWING HYPERTHERMIA THERAPY WITH MITOMYCIN C IN TREATING BCG UNRESPONSIVE NON-MUSCLE INVASIVE BLADDER CANCER: RECIRCULANT HYPERTHERMIC INTRAVESICAL CHEMOTHERAPY

Author

Stemberger, Andrew, primary, Tan, Wei Phin, additional, Bello, Ana Plata, additional, Garcia Alvarez, Juan Carlos, additional, Guerrero-Ramos, Félix, additional, González-Padilla, Daniel A., additional, Nzeh, Cajetan, additional, Manuel de la Morena, Jose, additional, Valcarcel de Torres, Ignacio Gonzalez, additional, Hendricksen, Kees, additional, Díaz-Goizueta, Francisco Javier, additional, Del Alamo, J. Fernandez, additional, Chiancone, Francesco, additional, Fedelini, Paolo, additional, Poggio, Massimiliano, additional, Porpiglia, Francesco, additional, Gonzalo Rodríguez, Victoria C., additional, Torres, Javier Montero, additional, Wilby, Daniel, additional, Robinson, Richard, additional, Sousa-Escandón, Alejandro, additional, León-Mata, Juan, additional, Pontones Moreno, Jose L., additional, Molina, Francisco Delgado, additional, Adriazola Semino, Miguel A., additional, Calleja-Escudero, Jesús, additional, Redorta, Joan Palou, additional, and Tan, Wei Shen, additional

Published
2022
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12. ASSESSMENT OF PATIENT CENTERED, CANCER SPECIFIC QUALITY METRICS IN ROBOT-ASSISTED RADICAL CYSTECTOMY: HOW DID WE PERFORM?: MP06-09

Author

Hussein, Ahmed, Peabody, James, Dibaj, Seyedeh, Wilding, Gregory, Mottrie, Alex, Hemal, Ashok, Scherr, Douglas, Schanne, Francis, Rha, Koon-Ho, Menon, Mani, Wiklund, Peter, Dasgupta, Prokar, Kahn, Shamim, Weizer, Alon, Redorta, Joan Palou, Richstone, Lee, Balbay, Derya M., Kibel, Adam, Kaouk, Jihad, Stockle, Michael, Woods, Michael, Hosseini, A K, Wilson, Timothy, Wijburg, Carl, Canda, Ali, and Guru, khurshid

Published
2016
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14. Endoscopic Management of Upper Urinary Tract Urothelial Carcinoma: Oncologic Outcomes and Prognostic Factors in a Contemporary Cohort

Author

Sanguedolce, Francesco, primary, Fontana, Matteo, additional, Turco, Morena, additional, Territo, Angelo, additional, Lucena, Josep Balañá, additional, Cortez, Julio Calderón, additional, Vanacore, Davide, additional, Meneghetti, Iacopo, additional, Gallioli, Andrea, additional, Gaya, Josep M., additional, Redorta, Joan Palou, additional, and Breda, Alberto, additional

Published
2021
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15. Clinical performance of serum isoform [-2]proPSA (p2PSA), and its derivatives %p2PSA and the Prostate Health Index, in men aged <60 years: results from a multicentric European study

Author

Fossati, Nicola, Lazzeri, Massimo, Haese, Alexander, McNicholas, Thomas, de la Taille, Alexandre, Buffi, Nicolò Maria, Lughezzani, Giovanni, Gadda, Giulio Maria, Lista, Giuliana, Larcher, Alessandro, Abrate, Alberto, Mistretta, Francesco, Bini, Vittorio, Redorta, Joan Palou, Graefen, Markus, and Guazzoni, Giorgio

Published
2015
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16. PD29-04 HISPANO-AMERICAN EXPERIENCE IN MINIMALLY INVASIVE PARTIAL NEPHRECTOMY

Author

Secin, Fernando Pablo, Cadiz, Octavio Castillo, García Marchiñena, Patricio Aitor, Navarro, Alberto Jurado, Rovegno, Agustin, Autran, Anamaria, Faba, Oscar Rodriguez, Redorta, Joan Palou, Rozanec, Jose, Featherstone, Marcelo, Holst, Pablo, Bragayrac, Luciano Nuñez, Sotelo, Rene, Faveretto, Ricardo, Zequi, Stenio, Maestro, Mario Álvarez, Piñeiro, Luis Martinez, Villoldo, Gustavo, Villaronga, Alberto, Clavijo, Diego Abreu, Mora, Ivar Vidal, Finkelstein, Diana, Monzo Gardiner, Juan Ignacio, Schatloff, Oscar, Porras, Andres Hernandez, Torres, Félix Santaella, Salas, Rodolfo Sanchez, Davila, Hugo Alberto, and Mavrich, Humberto Villavicencio

Published
2015
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17. Clinical performance of the Prostate Health Index (PHI) for the prediction of prostate cancer in obese men: data from the PROMEtheuS project, a multicentre European prospective study

Author

Abrate, Alberto, Lazzeri, Massimo, Lughezzani, Giovanni, Buffi, Nicolòmaria, Bini, Vittorio, Haese, Alexander, de la Taille, Alexandre, McNicholas, Thomas, Redorta, Joan Palou, Gadda, Giulio M., Lista, Giuliana, Kinzikeeva, Ella, Fossati, Nicola, Larcher, Alessandro, DellʼOglio, Paolo, Mistretta, Francesco, Freschi, Massimo, and Guazzoni, Giorgio

Published
2015
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18. P2PSA AND DERIVATIVES (%P2PSA AND PHI) ACCURATELY PREDICT PROSTATE CANCER IN OBESE MEN FROM A MULTICENTER PROSPECTIVE EUROPEAN STUDY: MP74-09

Author

Abrate, Alberto, Lazzeri, Massimo, Buffi, Nicolòmaria, Haese, Alexander, Taille, Alexandre de la, McNicholas, Thomas, Redorta, Joan Palou, Lughezzani, Giovanni, Gadda, Giulio Maria, Lista, Giuliana, Fossati, Nicola, Larcher, Alessandro, Kinzikeeva, Ella, DellʼOglio, Paolo, Mistretta, Francesco, Bini, Vittorio, Freschi, Massimo, Graefen, Markus, and Guazzoni, Giorgio

Published
2014
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19. EXTERNAL VALIDATION OF A PROSTATE HEALTH INDEX (PHI) BASED NOMOGRAM FOR PREDICTING PROSTATE CANCER AT EXTENDED BIOPSY IN A EUROPEAN MULTICENTER POPULATION: MP74-12

Author

Lughezzani, Giovanni, Lazzeri, Massimo, Haese, Alexander, McNicholas, Thomas, de la Taille, Alexandre, Buffi, Nicolòmaria, Lista, Giuliana, Kinzikeeva, Ella, Fossati, Nicola, Larcher, Alessandro, DellʼOglio, Paolo, Abrate, Alberto, Mistretta, Francesco, Bini, Vittorio, Redorta, Joan Palou, Graefen, Markus, and Guazzoni, Giorgio

Published
2014
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20. ONCOLOGICAL SAFETY AFTER ROBOT-ASSISTED RADICAL CYSTECTOMY: RESULTS FROM THE INTERNATIONAL ROBOTIC CYSTECTOMY CONSORTIUM: MP60-06

Author

Saar, Matthias, Raza, Syed Johar, Binkowski, John, Richstone, Lee, Wagner, Andrew, Wilson, Timothy, Redorta, Joan Palou, Dasgupta, Prokar, Peabody, James, Wiklund, Peter, Gaboardi, Franco, Mottrie, Alex, Siemer, Stephan, Pruthi, Raj, Weizer, Alon, Schanne, Francis, Guru, Khurshid, Rha, Koon-ho, Hemal, Ashok, Scherr, Douglas, and Stockle, Michael

Published
2014
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22. Additional file 2 of Quality of surgical care can impact survival in patients with bladder cancer after robot-assisted radical cystectomy: results from the International Robotic Cystectomy Consortium

Author

Ahmed, Youssef, Hussein, Ahmed A., May, Paul R., Ahmad, Basel, Khan, Amir, Benkowski, John, Durrani, Ayesha, Saira Khan, Kozlowski, Justen, Saar, Matthias, Wijburg, Carl J., Richstone, Lee, Wagner, Andrew, Yuh, Bertram, Redorta, Joan Palou, Prokar Dasgupta, Khan, Mohammad Shamim, Menon, Mani, Peabody, James O., Abolfazl Hosseini, Gaboardi, Franco, Giovannalberto Pini, Schanne, Francis, Mottrie, Alexandre, Koon-Ho Rha, Hemal, Ashok, Stockle, Michael, Kelly, John, Tan, Wei Shen, Maatman, Thomas J., Vassilis Poulakis, Kaouk, Jihad, Canda, Abdullah Erdem, Mevlana Derya Balbay, Wiklund, Peter, and Guru, Khurshid A.

Abstract

Additional file 2: Table S1. Life tables for RFS, DSS and OS for LAD (high vs low QCS) vs OCD (high vs low QCS).

Published
2020
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23. Additional file 1 of Quality of surgical care can impact survival in patients with bladder cancer after robot-assisted radical cystectomy: results from the International Robotic Cystectomy Consortium

Author

Ahmed, Youssef, Hussein, Ahmed A., May, Paul R., Ahmad, Basel, Khan, Amir, Benkowski, John, Durrani, Ayesha, Saira Khan, Kozlowski, Justen, Saar, Matthias, Wijburg, Carl J., Richstone, Lee, Wagner, Andrew, Yuh, Bertram, Redorta, Joan Palou, Prokar Dasgupta, Khan, Mohammad Shamim, Menon, Mani, Peabody, James O., Abolfazl Hosseini, Gaboardi, Franco, Giovannalberto Pini, Schanne, Francis, Mottrie, Alexandre, Koon-Ho Rha, Hemal, Ashok, Stockle, Michael, Kelly, John, Tan, Wei Shen, Maatman, Thomas J., Vassilis Poulakis, Kaouk, Jihad, Canda, Abdullah Erdem, Mevlana Derya Balbay, Wiklund, Peter, and Guru, Khurshid A.

Abstract

Additional file 1: Figure S1. Criteria included in QCS 22.

Published
2020
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24. Clinical performance of serum prostate-specific antigen isoform [-2]proPSA (p2PSA) and its derivatives, %p2PSA and the prostate health index (PHI), in men with a family history of prostate cancer: results from a multicentre European study, the PROMEtheuS project

Author

Lazzeri, Massimo, Haese, Alexander, Abrate, Alberto, de la Taille, Alexandre, Redorta, Joan Palou, McNicholas, Thomas, Lughezzani, Giovanni, Lista, Giuliana, Larcher, Alessandro, Bini, Vittorio, Cestari, Andrea, Buffi, Nicolòmaria, Graefen, Markus, Bosset, Olivier, Corvoisier, Philippe Le, Breda, Alberto, de la Torre, Pablo, Fowler, Linda, Roux, Jacques, and Guazzoni, Giorgio

Published
2013
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25. Impact of surgeon and volume on extended lymphadenectomy at the time of robot-assisted radical cystectomy: results from the International Robotic Cystectomy Consortium (IRCC)

Author

Marshall, Susan J., Hayn, Matthew H., Stegemann, Andrew P., Agarwal, Piyush K., Badani, Ketan K., Balbay, Derya M., Dasgupta, Prokar, Hemal, Ashok K., Hollenbeck, Brent K., Kibel, Adam S., Menon, Mani, Mottrie, Alex, Nepple, Kenneth, Pattaras, John G., Peabody, James O., Poulakis, Vassilis, Pruthi, Raj S., Redorta, Joan Palou, Rha, Koon-Ho, Richstone, Lee, Schanne, Francis, Scherr, Douglas S., Siemer, Stefan, Stöckle, Michael, Wallen, Eric M., Weizer, Alon Z., Wiklund, Peter, Wilson, Timothy, Woods, Michael, and Guru, Khurshid A.

Published
2013
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29. Outcomes of Intracorporeal Urinary Diversion after Robot-Assisted Radical Cystectomy: Results from the International Robotic Cystectomy Consortium

Author

Hussein, Ahmed A., May, Paul R., Jing, Zhe, Ahmed, Youssef E., Wijburg, Carl J., Canda, Abdulla Erdem, Dasgupta, Prokar, Shamim Khan, Mohammad, Menon, Mani, Peabody, James O., Hosseini, Abolfazl, Kelly, John, Mottrie, Alexandre, Kaouk, Jihad, Hemal, Ashok, Wiklund, Peter, Guru, Khurshid A., Wagner, Andrew, Saar, Matthias, Redorta, Joan Palou, Stockle, Michael, Richstone, Lee, Gaboardi, Franco, Badani, Ketan, Rha, Koon-Ho, Khan, Hijab, Kawa, Omar, Schanne, Francis, Polakis, Vassilis, Weizer, Alon, Scherr, Douglas, Pini, Giovannalberto, Tan, Wei Shen, Maatman, Thomas J., Kibel, Adam, Yuh, Bertram, and Peak, Taylor C.

Subjects
Male, medicine.medical_specialty, Urology, medicine.medical_treatment, International Cooperation, Operative Time, Urinary Bladder, 030232 urology & nephrology, Urinary Diversion, outcomes, Cystectomy, Patient Readmission, Extracorporeal, 03 medical and health sciences, cystectomy, 0302 clinical medicine, Postoperative Complications, Robotic Surgical Procedures, Risk Factors, medicine, Humans, Prospective Studies, intracorporeal, Aged, Retrospective Studies, Urinary bladder, business.industry, Urinary diversion, Perioperative, Robot-assisted, Middle Aged, Surgery, medicine.anatomical_structure, Outcome and Process Assessment, Health Care, Treatment Outcome, Robotic cystectomy, Urinary Bladder Neoplasms, diversion, 030220 oncology & carcinogenesis, Cohort, Female, business, human activities
Abstract

This study aimed to provide an update and compare perioperative outcomes and complications of intracorporeal and extracorporeal urinary diversion following robot-assisted radical cystectomy using data from the multi-institutional, prospectively maintained International Robotic Cystectomy Consortium database.We retrospectively reviewed the records of 2,125 patients from a total of 26 institutions. Intracorporeal urinary diversion was compared with extracorporeal urinary diversion. Multivariate logistic regression models using stepwise variable selection were fit to evaluate preoperative, operative and postoperative predictors of intracorporeal urinary diversion, operative time, high grade complications and 90-day hospital readmissions after robot-assisted radical cystectomy.In our cohort 1,094 patients (51%) underwent intracorporeal urinary diversion. These patients demonstrated shorter operative time (357 vs 400 minutes), less blood loss (300 vs 350 ml) and fewer blood transfusions (4% vs 19%, all p0.001). They experienced more high grade complications (13% vs 10%, p = 0.02). Intracorporeal urinary diversion use increased from 9% of all urinary diversions in 2005 to 97% in 2015. Complications after this procedure decreased significantly with time (p0.001). On multivariable analysis higher annual cystectomy volume (OR 1.02, 95% CI 1.01-1.03, p0.002), year of robot-assisted radical cystectomy (2013-2016 OR 68, 95% CI 44-105, p0.001) and American Society of Anesthesiologists® score less than 3 (OR 1.75, 95% CI 1.38-2.22, p0.001) were associated with undergoing intracorporeal urinary diversion. The procedure was associated with a shorter operative time of 27 minutes (p = 0.001).The use of intracorporeal urinary diversion has increased in the last decade. A higher annual institutional volume of robot-assisted radical cystectomy was associated with intracorporeal urinary diversion as well as with shorter operative time. Although intracorporeal urinary diversion was associated with higher grade complications than extracorporeal urinary diversion, they decreased with time.

Published
2017

31. Clinical performance of prostate health index in men with tPSA>10ng/ml: Results from a multicentric European study

Author

Lazzeri, Massimo, primary, Lughezzani, Giovanni, additional, Haese, Alexander, additional, McNicholas, Thomas, additional, de la Taille, Alexandre, additional, Buffi, Nicolò Maria, additional, Cardone, Pasquale, additional, Hurle, Rodolfo, additional, Casale, Paolo, additional, Bini, Vittorio, additional, Redorta, Joan Palou, additional, Graefen, Markus, additional, and Guazzoni, Giorgio, additional

Published
2016
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32. MP06-09 ASSESSMENT OF PATIENT CENTERED, CANCER SPECIFIC QUALITY METRICS IN ROBOT-ASSISTED RADICAL CYSTECTOMY: HOW DID WE PERFORM?

Author

Hussein, Ahmed, primary, Peabody, James, additional, Dibaj, Seyedeh, additional, Wilding, Gregory, additional, Mottrie, Alex, additional, Hemal, Ashok, additional, Scherr, Douglas, additional, Schanne, Francis, additional, Rha, Koon-Ho, additional, Menon, Mani, additional, Wiklund, Peter, additional, Dasgupta, Prokar, additional, Kahn, Shamim, additional, Weizer, Alon, additional, Redorta, Joan Palou, additional, Richstone, Lee, additional, Balbay, M. Derya, additional, Kibel, Adam, additional, Kaouk, Jihad, additional, Stockle, Michael, additional, Woods, Michael, additional, Hosseini, AK, additional, Wilson, Timothy, additional, Wijburg, Carl, additional, Canda, Ali, additional, and Guru, khurshid, additional

Published
2016
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33. Early Oncologic Failure after Robot-Assisted Radical Cystectomy: Results from the International Robotic Cystectomy Consortium.

Author

Hussein, Ahmed A., Saar, Matthias, May, Paul R., Wijburg, Carl J., Richstone, Lee, Wagner, Andrew, Wilson, Timothy, Yuh, Bertram, Redorta, Joan Palou, Dasgupta, Prokar, Khan, Mohammad Shamim, Menon, Mani, Peabody, James O., Hosseini, Abolfazl, Gaboardi, Franco, Mottrie, Alexandre, Rha, Koon-ho, Hemal, Ashok, Stockle, Michael, and Kelly, John

Subjects
SURGICAL robots, CYSTECTOMY, ONCOLOGIC surgery, SURGICAL complications, MEDICAL databases
Abstract

Purpose We sought to investigate the prevalence and variables associated with early oncologic failure. Materials and Methods We retrospectively reviewed the IRCC (International Radical Cystectomy Consortium) database of patients who underwent robot-assisted radical cystectomy since 2003. The final cohort comprised a total of 1,894 patients from 23 institutions in 11 countries. Early oncologic failure was defined as any disease relapse within 3 months of robot-assisted radical cystectomy. All institutions were surveyed for the pneumoperitoneum pressure used, breach of oncologic surgical principles, and techniques of specimen and lymph node removal. A multivariate model was fit to evaluate predictors of early oncologic failure. The Kaplan-Meier method was applied to depict disease specific and overall survival, and Cox proportional regression analysis was used to evaluate predictors of disease specific and overall survival. Results A total of 305 patients (22%) experienced disease relapse, which was distant in 220 (16%), local recurrence in 154 (11%), peritoneal carcinomatosis in 17 (1%) and port site recurrence in 5 (0.4%). Early oncologic failure developed in 71 patients (5%) at a total of 10 institutions. The incidence of early oncologic failure decreased from 10% in 2006 to 6% in 2015. On multivariate analysis the presence of any complication (OR 2.87, 95% CI 1.38–5.96, p = 0.004), pT3 or greater disease (OR 3.73, 95% CI 2.00–6.97, p <0.001) and nodal involvement (OR 2.14, 95% CI 1.21–3.80, p = 0.008) was a significant predictor of early oncologic failure. Patients with early oncologic failure demonstrated worse disease specific and overall survival (23% and 13%, respectively) at 1 and 3 years compared to patients who experienced later or no recurrences (log rank p <0.001). Conclusions The incidence of early oncologic failure following robot-assisted radical cystectomy has decreased with time. Disease related rather than technical related factors have a major role in early oncologic failure after robot-assisted radical cystectomy. [ABSTRACT FROM AUTHOR]

Published
2017
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34. Nonmuscle-invasive bladder cancer: what's changing and what has changed.

Author

Manikandan, Ramanitharan, Rodriguez, Oscar, Parada, Rubén, and Redorta, Joan Palou

Subjects
BLADDER cancer treatment, TRANSURETHRAL prostatectomy, CANCER invasiveness, BCG vaccines, MEDICAL quality control
Abstract

Purpose: Nonmuscle-invasive bladder cancer (NMIBC) is a challenging disease to manage primarily due to its varied clinical course. The management of NMIBC has witnessed a widespread change with respect to its diagnosis and treatment. Although transurethral resection (TUR) and adjuvant bacillus Calmette-Guerin (BCG) stills remain the cornerstone, newer protocols has come into vogue to achieve optimal care. On the basis of a literature review, we aimed to establish 'what changes has already occurred and what is expected in the future' in NMIBC. Methods: A Medline search was performed to identify the published literature with respect to diagnosis, treatment and future perspectives on NMIBC. Particular emphasis was directed to determinants such as the quality of TUR and the newer modifications, Re-TUR, current status of newer macroscopic and microscopic imaging, role of urinary biomarkers, clinical, histologic and molecular predictors of high-risk disease, administration of intravesical agents, salvage therapy in BCG recurrence and the current best practice guidelines were analyzed. Results and conclusions: Optimal TUR, restaging in select group, incorporation of newer endoscopic imaging and judicious administration of intravesical chemo-immunotherapeutic agents can contribute to better patient care. Although there is a plethora of urinary markers, there is insufficient evidence for their use in isolation. The future probably lies in identification of genetic markers to determine disease recurrence, nonresponders to standard treatment and early institution of alternative/targeted therapy. [ABSTRACT FROM AUTHOR]

Published
2017
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36. MP74-12 EXTERNAL VALIDATION OF A PROSTATE HEALTH INDEX (PHI) BASED NOMOGRAM FOR PREDICTING PROSTATE CANCER AT EXTENDED BIOPSY IN A EUROPEAN MULTICENTER POPULATION

Author

Lughezzani, Giovanni, primary, Lazzeri, Massimo, additional, Haese, Alexander, additional, McNicholas, Thomas, additional, de la Taille, Alexandre, additional, Buffi, Nicolòmaria, additional, Lista, Giuliana, additional, Kinzikeeva, Ella, additional, Fossati, Nicola, additional, Larcher, Alessandro, additional, Dell'Oglio, Paolo, additional, Abrate, Alberto, additional, Mistretta, Francesco, additional, Bini, Vittorio, additional, Redorta, Joan Palou, additional, Graefen, Markus, additional, and Guazzoni, Giorgio, additional

Published
2014
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37. MP74-09 P2PSA AND DERIVATIVES (%P2PSA AND PHI) ACCURATELY PREDICT PROSTATE CANCER IN OBESE MEN FROM A MULTICENTER PROSPECTIVE EUROPEAN STUDY

Author

Abrate, Alberto, primary, Lazzeri, Massimo, additional, Buffi, Nicolòmaria, additional, Haese, Alexander, additional, Taille, Alexandre de la, additional, McNicholas, Thomas, additional, Redorta, Joan Palou, additional, Lughezzani, Giovanni, additional, Gadda, Giulio Maria, additional, Lista, Giuliana, additional, Fossati, Nicola, additional, Larcher, Alessandro, additional, Kinzikeeva, Ella, additional, Dell'Oglio, Paolo, additional, Mistretta, Francesco, additional, Bini, Vittorio, additional, Freschi, Massimo, additional, Graefen, Markus, additional, and Guazzoni, Giorgio, additional

Published
2014
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38. MP60-06 ONCOLOGICAL SAFETY AFTER ROBOT-ASSISTED RADICAL CYSTECTOMY: RESULTS FROM THE INTERNATIONAL ROBOTIC CYSTECTOMY CONSORTIUM

Author

Saar, Matthias, primary, Raza, Syed Johar, additional, Binkowski, John, additional, Richstone, Lee, additional, Wagner, Andrew, additional, Wilson, Timothy, additional, Redorta, Joan Palou, additional, Dasgupta, Prokar, additional, Peabody, James, additional, Wiklund, Peter, additional, Gaboardi, Franco, additional, Mottrie, Alex, additional, Siemer, Stephan, additional, Pruthi, Raj, additional, Weizer, Alon, additional, Schanne, Francis, additional, Guru, Khurshid, additional, Rha, Koon-ho, additional, Hemal, Ashok, additional, Scherr, Douglas, additional, and Stockle, Michael, additional

Published
2014
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39. Analysis of Intracorporeal Compared with Extracorporeal Urinary Diversion After Robot-assisted Radical Cystectomy: Results from the International Robotic Cystectomy Consortium

Author

Ahmed, Kamran, primary, Khan, Shahid A., additional, Hayn, Matthew H., additional, Agarwal, Piyush K., additional, Badani, Ketan K., additional, Balbay, M. Derya, additional, Castle, Erik P., additional, Dasgupta, Prokar, additional, Ghavamian, Reza, additional, Guru, Khurshid A., additional, Hemal, Ashok K., additional, Hollenbeck, Brent K., additional, Kibel, Adam S., additional, Menon, Mani, additional, Mottrie, Alex, additional, Nepple, Kenneth, additional, Pattaras, John G., additional, Peabody, James O., additional, Poulakis, Vassilis, additional, Pruthi, Raj S., additional, Redorta, Joan Palou, additional, Rha, Koon-Ho, additional, Richstone, Lee, additional, Saar, Matthias, additional, Scherr, Douglas S., additional, Siemer, Stefan, additional, Stoeckle, Michael, additional, Wallen, Eric M., additional, Weizer, Alon Z., additional, Wiklund, Peter, additional, Wilson, Timothy, additional, Woods, Michael, additional, and Khan, Muhammad Shamim, additional

Published
2014
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41. 1407 IS ROBOT-ASSISTED RADICAL CYSTECTOMY EFFECTIVE FOR T3 BLADDER CANCER? RESULTS FROM THE INTERNATIONAL ROBOTIC CYSTECTOMY CONSORTIUM

Author

Hayn, Matthew H., primary, El-Nahas, Ahmed, additional, Stegemann, Andrew P., additional, Agarwal, Piyush K., additional, Badani, Ketan K., additional, Balbay, M. Derya, additional, Castle, Erik P., additional, Dasgupta, Prokar, additional, Ghavamian, Reza, additional, Hemal, Ashok K., additional, Hollenbeck, Brent K., additional, Josephson, David, additional, Kader, A. Karim, additional, Kahn, Shamim, additional, Kibel, Adam S., additional, Menon, Mani, additional, Mottrie, Alex, additional, Nepple, Kenneth, additional, Pattaras, John G., additional, Peabody, James O., additional, Poulakis, Vassilis, additional, Pruthi, Raj S., additional, Redorta, Joan Palou, additional, Rha, Koon-Ho, additional, Richstone, Lee, additional, Saar, Matthias, additional, Scherr, Douglas S., additional, Siemer, Stefan, additional, Stoeckle, Michael, additional, Wallen, Eric M., additional, Weizer, Alon Z., additional, Wiklund, Peter, additional, Wilson, Timothy, additional, Woods, Michael, additional, and Guru, Khurshid A., additional

Published
2012
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42. 1161 COMPARISON OF OUTCOMES BETWEEN INTRA-CORPOREAL AND EXTRA-CORPOREAL URINARY DIVERSION AFTER ROBOT-ASSISTED RADICAL CYSTECTOMY – THE IRCC RESULTS

Author

Ahmed, Kamran, primary, Hayn, Matthew H., additional, Stegemann, Andrew P., additional, Agarwal, Piyush K., additional, Badani, Ketan K., additional, Balbay, M. Derya, additional, Castle, Erik P., additional, Dasgupta, Prokar, additional, Ghavamian, Reza, additional, Guru, Khurshid A., additional, Hemal, Ashok K., additional, Hollenbeck, Brent K., additional, Josephson, David, additional, Kader, A. Karim, additional, Kibel, Adam S., additional, Menon, Mani, additional, Mottrie, Alex, additional, Nepple, Kenneth, additional, Pattaras, John G., additional, Peabody, James O., additional, Poulakis, Vassilis, additional, Pruthi, Raj S., additional, Redorta, Joan Palou, additional, Rha, Koon-Ho, additional, Richstone, Lee, additional, Saar, Matthias, additional, Scherr, Douglas S., additional, Siemer, Stefan, additional, Stoeckle, Michael, additional, Wallen, Eric M., additional, Weizer, Alon Z., additional, Wiklund, Peter, additional, Wilson, Timothy, additional, Woods, Michael, additional, and Kahn, Shamim, additional

Published
2012
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43. The Role of Laparoscopic and Robotic Cystectomy in the Management of Muscle-Invasive Bladder Cancer With Special Emphasis on Cancer Control and Complications

Author

Challacombe, Ben J., primary, Bochner, Bernard H., additional, Dasgupta, Prokar, additional, Gill, Inderbir, additional, Guru, Khurshid, additional, Herr, Harry, additional, Mottrie, Alexander, additional, Pruthi, Raj, additional, Redorta, Joan Palou, additional, and Wiklund, Peter, additional

Published
2011
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44. 1141 TOTAL INTRA-CORPOREAL URINARY DIVERSION AFTER ROBOT-ASSISTED RADICAL CYSTECTOMY: THE INTERNATIONAL ROBOTIC CYSTECTOMY CONSORTIUM RESULTS AFTER 134 CASES

Author

Guru, Khurshid A., primary, Hayn, Matthew H., additional, Stegemann, Andrew P., additional, Agarwal, Piyush K., additional, Balbay, M. Derya, additional, Mottrie, Alex, additional, Peabody, James O., additional, Poulakis, Vassilis, additional, Redorta, Joan Palou, additional, and Wiklund, Peter, additional

Published
2011
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45. 1415 PATHOLOGIC AND EARLY ONCOLOGIC OUTCOMES AFTER ROBOT-ASSISTED RADICAL CYSTECTOMY: RESULTS FROM THE INTERNATIONAL ROBOTIC CYSTECTOMY CONSORTIUM

Author

Hayn, Matthew H., primary, Stegemann, Andrew P., additional, Agarwal, Piyush K., additional, Badani, Ketan K., additional, Balbay, M. Derya, additional, Castle, Erik P., additional, Dasgupta, Prokar, additional, Hellenthal, Nicholas J., additional, Hemal, Ashok K., additional, Josephson, David, additional, Kader, A. Karim, additional, Kibel, Adam S., additional, Mottrie, Alex, additional, Nepple, Kenneth, additional, Pattaras, John G., additional, Peabody, James O., additional, Poulakis, Vassilis, additional, Pruthi, Raj S., additional, Redorta, Joan Palou, additional, Rha, Koon-Ho, additional, Richstone, Lee, additional, Saar, Matthias, additional, Scherr, Douglas S., additional, Siemer, Stefan, additional, Stoeckle, Michael, additional, Wallen, Eric M., additional, Wiklund, Peter, additional, Wilson, Timothy, additional, Woods, Michael, additional, Yuh, Bertram, additional, and Guru, Khurshid A., additional

Published
2011
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46. 1405 LYMPH NODE YIELD AND PREDICTORS OF EXTENDED LYMPHADENECTOMY AT THE TIME OF ROBOT-ASSISTED RADICAL CYSTECTOMY: RESULTS FROM THE INTERNATIONAL ROBOTIC CYSTECTOMY CONSORTIUM

Author

Marshall, Susan J., primary, Hayn, Matthew H., additional, Stegemann, Andrew P., additional, Agarwal, Piyush K., additional, Badani, Ketan K., additional, Balbay, M. Derya, additional, Castle, Erik P., additional, Dasgupta, Prokar, additional, Hemal, Ashok K., additional, Josephson, David, additional, Kader, A. Karim, additional, Kibel, Adam S., additional, Mottrie, Alex, additional, Nepple, Kenneth, additional, Pattaras, John G., additional, Peabody, James O., additional, Poulakis, Vassilis, additional, Pruthi, Raj S., additional, Redorta, Joan Palou, additional, Rha, Koon-Ho, additional, Richstone, Lee, additional, Saar, Matthias, additional, Scherr, Douglas S., additional, Siemer, Stefan, additional, Stoeckle, Michael, additional, Wallen, Eric M., additional, Wiklund, Peter, additional, Wilson, Timothy, additional, Woods, Michael, additional, Yuh, Bertram, additional, and Guru, Khurshid A., additional

Published
2011
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47. Reply from Authors re: Urs E. Studer, Laurence Collette. Robot-Assisted Cystectomy: Does It Meet Expectations? Eur Urol 2010;58:203–4

Author

Hayn, Matthew H., primary, Hussain, Abid, additional, Mansour, Ahmed M., additional, Andrews, Paul E., additional, Carpentier, Paul, additional, Castle, Erik, additional, Dasgupta, Prokar, additional, Rimington, Peter, additional, Thomas, Raju, additional, Khan, Shamim, additional, Kibel, Adam, additional, Kim, Hyung, additional, Manoharan, Murugesan, additional, Menon, Mani, additional, Mottrie, Alex, additional, Ornstein, David, additional, Peabody, James, additional, Pruthi, Raj, additional, Redorta, Joan Palou, additional, Richstone, Lee, additional, Schanne, Francis, additional, Stricker, Hans, additional, Wiklund, Peter, additional, Chandrasekhar, Rameela, additional, Wilding, Greg E., additional, and Guru, Khurshid A., additional

Published
2010
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48. Clinical performance of serum isoform [-2]pro PSA ( p2PSA), and its derivatives % p2PSA and the Prostate Health Index, in men aged <60 years: results from a multicentric European study.

Author

Fossati, Nicola, Lazzeri, Massimo, Haese, Alexander, McNicholas, Thomas, Taille, Alexandre, Buffi, Nicolò Maria, Lughezzani, Giovanni, Gadda, Giulio Maria, Lista, Giuliana, Larcher, Alessandro, Abrate, Alberto, Mistretta, Francesco, Bini, Vittorio, Redorta, Joan Palou, Graefen, Markus, and Guazzoni, Giorgio

Subjects
PROSTATE cancer, DIAGNOSIS, PROSTATE-specific antigen, MEN'S health, MULTIVARIATE analysis, BIOPSY
Abstract

Objectives To test the hypothesis that [-2]pro PSA ( p2PSA) and its derivatives are more accurate than total prostate-specific antigen ( tPSA), free prostate-specific antigen ( fPSA) and fPSA as percentage of tPSA (% fPSA) in detecting prostate cancer ( PCa) in men aged <60 years. Patients and Methods The analysis consisted of a nested case-control study from the PRO- PSA Multicentric European Study ( PROMEtheuS) project. The primary outcomes were measures of sensibility, specificity and accuracy of serum p2PSA, p2PSA as percentage of fPSA (% p2PSA) and Beckman Coulter prostate health index ( PHI) in men aged <60 years who had undergone a prostate biopsy. The potential reduction in the number of unnecessary biopsies and the characteristics of the potentially missed PCa cases were reported as secondary outcomes. Multivariate logistic regression models were complemented by predictive accuracy and decision-curve analyses. Results Of the 1036 patients enrolled in the PROMEtheus project, 238 (22.9%) were aged < 60 years. PCa was found in 67 subjects (28.1%); p2PSA, % p2PSA and PHI values were significantly higher ( P < 0.001) among these subjects, while no differences were found in tPSA, fPSA and % fPSA values. On univariate analysis, % p2PSA (area under the curve [ AUC]: 0.704) and PHI ( AUC: 0.7) were the most accurate predictors, and these significantly outperformed tPSA ( AUC: 0.549), fPSA ( AUC: 0.511) and % fPSA ( AUC: 0.557) in the prediction of PCa at biopsy ( P ≤ 0.001). In multivariate logistic regression models, % p2PSA and PHI achieved independent predictor status and significantly increased the accuracy of multivariate models by 6.3 and 7.6%, respectively ( P ≤ 0.05). Conclusion PHI and % p2PSA are more accurate than the reference standard tests in predicting PCa in young men. [ABSTRACT FROM AUTHOR]

Published
2015
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49. International Robotic Radical Cystectomy Consortium: A way forward.

Author

Raza, Syed Johar, Field, Erinn, Kibel, Adam S., Mottrie, Alex, Weizer, Alon Z., Wagner, Andrew, Hemal, Ashok K., Scherr, Douglas S., Schanne, Francis, Gaboardi, Franco, Guan Wu, Peabody, James O., Koauk, Jihad, Redorta, Joan Palou, Pattaras, John G., Rha, Koon-Ho, Richstone, Lee, Balbay, M. Derya, Menon, Mani, and Hayn, Mathew

Subjects
CYSTECTOMY, BLADDER tumors, DATABASES, DIFFUSION of innovations, ENDOSCOPIC surgery, SURGICAL excision, HEALTH, LYMPH node surgery, HEALTH outcome assessment, PROSTATECTOMY, ROBOTICS, TREATMENT effectiveness
Abstract

Robot-assisted radical cystectomy (RARC) is an emerging operative alternative to open surgery for the management of invasive bladder cancer. Studies from single institutions provide limited data due to the small number of patients. In order to better understand the related outcomes, a world-wide consortium was established in 2006 of patients undergoing RARC, called the International Robotic Cystectomy Consortium (IRCC). Thus far, the IRCC has reported its findings on various areas of operative interest and continues to expand its capacity to include other operative modalities and transform it into the International Radical Cystectomy Consortium. This article summarizes the findings of the IRCC and highlights the future direction of the consortium. [ABSTRACT FROM AUTHOR]

Published
2014
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50. Clinical performance of serum prostate-specific antigen isoform [-2] proPSA ( p2PSA) and its derivatives, % p2PSA and the prostate health index ( PHI), in men with a family history of prostate cancer: results from a multicentre European study, the PROMEtheuS project

Author

Lazzeri, Massimo, Haese, Alexander, Abrate, Alberto, Taille, Alexandre, Redorta, Joan Palou, McNicholas, Thomas, Lughezzani, Giovanni, Lista, Giuliana, Larcher, Alessandro, Bini, Vittorio, Cestari, Andrea, Buffi, Nicolòmaria, Graefen, Markus, Bosset, Olivier, Corvoisier, Philippe Le, Breda, Alberto, Torre, Pablo, Fowler, Linda, Roux, Jacques, and Guazzoni, Giorgio

Subjects
PROSTATE-specific antigen, PROSTATE cancer, BIOPSY, CASE-control method, LOGISTIC regression analysis
Abstract

Objectives To test the sensitivity, specificity and accuracy of serum prostate-specific antigen isoform [-2] proPSA ( p2PSA), % p2PSA and the prostate health index ( PHI), in men with a family history of prostate cancer ( PCa) undergoing prostate biopsy for suspected PCa., To evaluate the potential reduction in unnecessary biopsies and the characteristics of potentially missed cases of PCa that would result from using serum p2PSA, %p2 PSA and PHI., Patients and Methods The analysis consisted of a nested case-control study from the PRO-PSA Multicentric European Study, the PROMEtheuS project., All patients had a first-degree relative (father, brother, son) with PCa., Multivariable logistic regression models were complemented by predictive accuracy analysis and decision-curve analysis., Results Of the 1026 patients included in the PROMEtheuS cohort, 158 (15.4%) had a first-degree relative with PCa. p2PSA, % p2PSA and PHI values were significantly higher ( P < 0.001), and free/total PSA (% fPSA) values significantly lower ( P < 0.001) in the 71 patients with PCa (44.9%) than in patients without PCa., Univariable accuracy analysis showed % p2PSA (area under the receiver-operating characteristic curve [ AUC]: 0.733) and PHI ( AUC: 0.733) to be the most accurate predictors of PCa at biopsy, significantly outperforming total PSA ([ tPSA] AUC: 0.549), free PSA ([ fPSA] AUC: 0.489) and % fPSA ( AUC: 0.600) ( P ≤ 0.001)., For % p2PSA a threshold of 1.66 was found to have the best balance between sensitivity and specificity (70.4 and 70.1%; 95% confidence interval [ CI]: 58.4-80.7 and 59.4-79.5 respectively). A PHI threshold of 40 was found to have the best balance between sensitivity and specificity (64.8 and 71.3%, respectively; 95% CI 52.5-75.8 and 60.6-80.5)., At 90% sensitivity, the thresholds for % p2PSA and PHI were 1.20 and 25.5, with a specificity of 37.9 and 25.5%, respectively. At a % p2PSA threshold of 1.20, a total of 39 (24.8%) biopsies could have been avoided, but two cancers with a Gleason score ( GS) of 7 would have been missed. At a PHI threshold of 25.5 a total of 27 (17.2%) biopsies could have been avoided and two (3.8%) cancers with a GS of 7 would have been missed., In multivariable logistic regression models, % p2PSA and PHI achieved independent predictor status and significantly increased the accuracy of multivariable models including PSA and prostate volume by 8.7 and 10%, respectively ( P ≤ 0.001)., p2PSA, %p2 PSA and PHI were directly correlated with Gleason score (ρ: 0.247, P = 0.038; ρ: 0.366, P = 0.002; ρ: 0.464, P < 0.001, respectively)., Conclusions % p2PSA and PHI are more accurate than tPSA, fPSA and % fPSA in predicting PCa in men with a family history of PCa., Consideration of % p2PSA and PHI results in the avoidance of several unnecessary biopsies., p2PSA, % p2PSA and PHI correlate with cancer aggressiveness. [ABSTRACT FROM AUTHOR]

Published
2013
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