Search

Your search keyword '"Redondo, Marina"' showing total 47 results
Start Over Author "Redondo, Marina"
47 results on '"Redondo, Marina"'

1. Donor Lung Preservation at 10 °C: Clinical and Logistical Impact

Author

Gil Barturen, Mariana, Laporta Hernández, Rosalía, Romero Berrocal, Antonio, Pérez Redondo, Marina, Gómez Lozano, Natalia, Martín López, Javier, Royuela Vicente, Ana, Romero Román, Alejandra, Hoyos Mejía, Lucas, Crowley Carrasco, Silvana, Gómez de Antonio, David, Naranjo Gómez, Jose Manuel, Córdoba Peláez, Mar, Novoa, Nuria María, and Campo-Cañaveral de la Cruz, Jose Luis

Published
2024
Full Text
View/download PDF

2. The international experience of in-situ recovery of the DCD heart: a multicentre retrospective observational study

Author

Patel, Nirav, Sanghera, Rohan, Kapetanos, Constantinos, Rubino, Antonio, Bhagra, Sai, Martinez-Marin, Luis-Alberto, Allen, Jordan, John, Chindu, Normington, Daniel, Tsui, Steven, Page, Aravinda, Chow, Vanessa, McMaster, William, Pérez-Blanco, Alicia, Torres, Elisabeth, Cuenca, José, Mosteiro, Fernando, Farrero, Marta, Sandoval, Elena, Camino, Manuela, Jáurena, Juan, Sbraga, Fabrizio, Oliver, Eva, Quintana, Antonio, Morant, Vincente, Estébanez, Belen, Rocafort, Álvaro, Cobo, Manuel, Nistal, Francisco, Gómez-Bueno, Manuel, Pérez-Redondo, Marina, Neyrinck, Arne, Monbaliu, Diethard, Ceulemans, Laurens, Louca, John, Öchsner, Marco, Shah, Ashish, Hoffman, Jordan, Debose-Scarlett, Alexandra, Vilchez, Francisco González, Garrido, Iris, Royo-Villanova, Mario, Domínguez-Gil, Beatriz, Smith, Deane, James, Leslie, Moazami, Nader, Rega, Filip, Brouckaert, Janne, Van Cleemput, Johan, Vandendriessche, Katrien, Tchana-Sato, Vincent, Bandiougou, Diawara, Urban, Marian, Manara, Alex, Berman, Marius, Messer, Simon, and Large, Stephen

Published
2023
Full Text
View/download PDF

5. Donación en asistolia controlada: cómo iniciar un programa

Author

Villar-García, Susana, Martín-López, Carlos E., Pérez-Redondo, Marina, Hernández-Pérez, Francisco J., Martínez-López, Daniel, de Villarreal-Soto, Juan E., Ríos-Rosado, Elsa C., Vera-Puente, Beatriz, Ospina-Mosquera, Víctor M., Serrano-Fiz, Santiago, and Forteza-Gil, Alberto

Published
2022
Full Text
View/download PDF

6. Outcomes after lung transplantation from selected donors older than 70 years in a single centre: time to close the debate?

Author

Romero Román, Alejandra, primary, Gil Barturen, Mariana, additional, Crowley Carrasco, Silvana, additional, Hoyos Mejía, Lucas, additional, Naranjo Gómez, Jose Manuel, additional, Córdoba Peláez, Mar, additional, Pérez Redondo, Marina, additional, Royuela Vicente, Ana, additional, García Fadul, Christian, additional, Gómez de Antonio, David, additional, Novoa, Nuria María, additional, and Campo-Cañaveral de la Cruz, Jose Luis, additional

Published
2024
Full Text
View/download PDF

7. Improved short-term outcomes of kidney transplants in controlled donation after the circulatory determination of death with the use of normothermic regional perfusion

Author

Padilla, María, Coll, Elisabeth, Fernández-Pérez, Cristina, Pont, Teresa, Ruiz, Ángel, Pérez-Redondo, Marina, Oliver, Eva, Atutxa, Lander, Manciño, José M., Daga, Domingo, Miñambres, Eduardo, Moya, José, Vidal, Bárbara, Dueñas-Jurado, José M., Mosteiro, Fernando, Rodríguez-Salgado, Alberto, Fernández-García, Esperanza, Lara, Ramón, Hernández-Marrero, Domingo, Estébanez, Belén, Rodríguez-Ferrero, María Luisa, Barber, María, García-López, Fernando, Andrés, Amado, Santiago, Carlos, Zapatero, Ana, Badenes, Rafael, Carrizosa, Francisco, Blanco, José J., Bernal, José L., Elola, Francisco J., Vidal, Cristina, Terrón, Christel, Castro, Pablo, Comas, Jordi, and Domínguez-Gil, Beatriz

Published
2021
Full Text
View/download PDF

8. Malignancies in Deceased Organ Donors: The Spanish Experience

Author

Mahíllo, Beatriz, Martín, Silvia, Molano, Esteban, Navarro, Aurora, Castro, Pablo, Pont, Teresa, Andrés, Amado, Galán, Juan, López, Montserrat, Oliver, Eva, Martínez, Adolfo, Mosteiro, Fernando, Roque, Rebeca, Pérez-Redondo, Marina, Cid-Cumplido, Manuela, Ballesteros, María A., Daga, Domingo, Quindós, Brígida, Sancho, Micaela, Royo-Villanova, Mario, Bernabé, Esther, Muñoz, Raúl, Chacón, José Ignacio, Coll, Elisabeth, and Domínguez-Gil, Beatriz

Published
2022
Full Text
View/download PDF

9. Systemic Inflammation Differences in Brain-vs. Circulatory-Dead Donors: Impact on Lung Transplant Recipients.

Author

Sandiumenge, Alberto, Bello, Irene, Coll-Torres, Elisabeth, Gomez-Brey, Aroa, Franco-Jarava, Clara, Miñambres, Eduardo, Pérez-Redondo, Marina, Mosteiro, Fernando, Sánchez-Moreno, Laura, Crowley, Silvana, Fieira, Eva, Suberviola, Borja, Alan Mazo, Cristopher, Agustí, Alvar, and Pont, Teresa

Subjects
LUNG transplantation, INFLAMMATION, BRAIN death, INTERLEUKIN-10, KIDNEY transplantation, INTERLEUKIN-6
Abstract

Brain death triggers a systemic inflammatory response. Whether systemic inflammation is different in lung donors after brain- (DBD) or circulatory-death (DCD) is unknown, but this may potentially increase the incidence of primary graft dysfunction (PGD) after lung transplantation. We compared the plasma levels of interleukin (IL)-6, IL-8, IL-10 and TNF-α in BDB and DCD and their respective recipients, as well as their relationship with PGD and mortality after LT. A prospective, observational, multicenter, comparative, cohort-nested study that included 40 DBD and 40 DCD lung donors matched and their respective recipients. Relevant clinical information and blood samples were collected before/during lung retrieval in donors and before/during/after (24, 48 and 72 h) LT in recipients. Incidence of PGD and short-term mortality after LT was recorded. Plasma levels of all determined cytokines were numerically higher in DBD than in DCD donors and reached statistical significance for IL-6, IL-10 and IL-8. In recipients with PGD the donor’s plasma levels of TNF-α were higher. The postoperative mortality rate was very low and similar in both groups. DBD is associated with higher systemic inflammation than DCD donors, and higher TNF-α plasma levels in donors are associated with a higher incidence of PGD [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

10. Outcomes after lung transplantation from selected donors older than 70 years in a single centre: time to close the debate?

Author

Román, Alejandra Romero, Barturen, Mariana Gil, Carrasco, Silvana Crowley, Mejía, Lucas Hoyos, Gómez, Jose Manuel Naranjo, Peláez, Mar Córdoba, Redondo, Marina Pérez, Vicente, Ana Royuela, Fadul, Christian García, Antonio, David Gómez de, Novoa, Nuria María, and Cruz, Jose Luis Campo-Cañaveral de la

Subjects
LUNG transplantation, HOMOGRAFTS, FORCED expiratory volume, PROPENSITY score matching, KIDNEY transplantation, PULMONARY function tests
Abstract

Open in new tab Download slide OBJECTIVES The aim of this study was to compare the outcomes of lung transplantations using grafts from donors aged over 70 years against those performed using younger donors. METHODS This retrospective single-centre analysis includes lung transplants conducted at our institution from January 2014 to June 2022. Lung recipients were classified into 2 groups based on donor age (group A <70 years; group B ≥70 years). Variables regarding demographics, peri and postoperative outcomes and survival were included. The statistical analysis approach included univariable analysis, propensity score matching to address imbalances in donor variables (smoking status), recipient characteristics (sex, age, diagnosis and lung allocation score) and calendar period and survival analysis. RESULTS A total of 353 lung transplants were performed in this period, 47 (13.3%) using grafts from donors aged over 70 years. Donors in group B were more frequently women (70.2% vs 51.6%, P  = 0.017), with less smoking history (22% vs 43%, P  = 0.002) and longer mechanical ventilation time (3 vs 2 days, P  = 0.025). Recipients in group B had a higher lung allocation score (37.5 vs 35, P  = 0.035). Postoperative variables were comparable between both groups, except for pulmonary function tests. Group B demonstrated lower forced expiratory volume 1 s levels (2070 vs 2580 ml, P  = 0.001). The propensity score matching showed a lower chance of chronic lung allograft dysfunction by 12% for group B. One-, three- and five-year survival was equal between the groups. CONCLUSIONS The use of selected expanded-criteria donors aged over 70 years did not result in increased postoperative morbidity, early mortality or survival in this study. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

11. Transplantation of a heart donated after circulatory death via thoraco-abdominal normothermic regional perfusion and results from the first Spanish case

Author

Pérez Redondo, Marina, Alcántara Carmona, Sara, Villar García, Susana, Forteza Gil, Alberto, Villanueva Fernández, Héctor, Hernández-Pérez, Francisco José, Campo-Cañaveral de la Cruz, José Luis, Velasco Calvo, Rocío, Segovia-Cubero, Javier, Alonso Menárguez, Beatriz, del Río Gallegos, Francisco, Coll, Elisabeth, Domínguez-Gil González, Beatriz, and Rubio Muñoz, Juan José

Published
2020
Full Text
View/download PDF

13. The international experience of in-situ recovery of the DCD heart: a multicentre retrospective observational study

Author

Louca, John, primary, Öchsner, Marco, additional, Shah, Ashish, additional, Hoffman, Jordan, additional, Vilchez, Francisco González, additional, Garrido, Iris, additional, Royo-Villanova, Mario, additional, Domínguez-Gil, Beatriz, additional, Smith, Deane, additional, James, Leslie, additional, Moazami, Nader, additional, Rega, Filip, additional, Brouckaert, Janne, additional, Van Cleemput, Johan, additional, Vandendriessche, Katrien, additional, Tchana-Sato, Vincent, additional, Bandiougou, Diawara, additional, Urban, Marian, additional, Manara, Alex, additional, Berman, Marius, additional, Messer, Simon, additional, Large, Stephen, additional, Patel, Nirav, additional, Sanghera, Rohan, additional, Kapetanos, Constantinos, additional, Rubino, Antonio, additional, Bhagra, Sai, additional, Martinez-Marin, Luis-Alberto, additional, Allen, Jordan, additional, John, Chindu, additional, Normington, Daniel, additional, Tsui, Steven, additional, Page, Aravinda, additional, Chow, Vanessa, additional, McMaster, William, additional, Pérez-Blanco, Alicia, additional, Torres, Elisabeth, additional, Cuenca, José, additional, Mosteiro, Fernando, additional, Farrero, Marta, additional, Sandoval, Elena, additional, Camino, Manuela, additional, Jáurena, Juan, additional, Sbraga, Fabrizio, additional, Oliver, Eva, additional, Quintana, Antonio, additional, Morant, Vincente, additional, Estébanez, Belen, additional, Rocafort, Álvaro, additional, Cobo, Manuel, additional, Nistal, Francisco, additional, Gómez-Bueno, Manuel, additional, Pérez-Redondo, Marina, additional, Neyrinck, Arne, additional, Monbaliu, Diethard, additional, and Ceulemans, Laurens, additional

Published
2023
Full Text
View/download PDF

15. Interrupted versus continuous suture for bronchial anastomosis in lung transplantation: does it matter?

Author

Gil Barturen, Mariana, primary, Campo-Cañaveral de la Cruz, Jose Luis, additional, Crowley Carrasco, Silvana, additional, Romero Román, Alejandra, additional, Hoyos Mejía, Lucas, additional, Peyró, María, additional, Díaz Nuevo, Gema, additional, López García-Gallo, Cristina, additional, Pérez Redondo, Marina, additional, Royuela Vicente, Ana, additional, Tanaka, Shin, additional, Naranjo Gómez, Jose Manuel, additional, Córdoba Peláez, Mar, additional, Varela de Ugarte, Andrés, additional, and Gómez de Antonio, David, additional

Published
2022
Full Text
View/download PDF

16. Project of Support to Controlled Donation after Circulatory Death Through a Normothermal Regional Perfusion Mobile Equipment for Hospitals of the Community of Madrid. Spain. Start-Up and Preliminary Result

Author

Redondo, Marina Pérez, Simón, Inmaculada Fernández, Vallhonrat, Inés Lipperheide, Rey, Cándido Pardo, López, Alfonso Ortega, Fernández, Héctor Villanueva, Carmona, Sara Alcántara, Romero, Manuel González, José, Rubio Muñoz Juan, and del Río Gallegos, Francisco

Published
2018
Full Text
View/download PDF

17. Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals

Author

Inmunología, microbiología y parasitología, Immunologia, mikrobiologia eta parasitologia, Goikoetxea Usandizaga, Naroa, Serrano Maciá, Marina, Delgado, Teresa C., Simón Espinosa, Jorge, Fernández Ramos, David, Barriales, Diego, Cornide, María E., Jiménez, Mónica, Pérez Redondo, Marina, Lachiondo Ortega, Sofía, Rodríguez Agudo, Rubén, Bizkarguenaga, Maider, Diego Zalamea, Juan, Pasco, Samuel T., Caballero Díaz, Daniel, Alfano, Benedetta, Bravo Garmendia, Miren, González Recio, Irene, Mercado Gómez, María, Gil Pitarch, Clàudia, Mabe Alvarez, Jon, Gracia Sancho, Jordi, Abecia Aliende, Leticia, Lorenzo, Oscar, Martín Sanz, Paloma, Abrescia, Nicola A.G., Sabio, Guadalupe, Rincón, Mercedes, Anguita Castillo, Juan de Dios, Miñambres, Eduardo, Martín, César, Berenguer, Marina, Fabregat, Isabel, Casado, Marta, Peralta, Carmen, Varela Rey, Marta, Martínez Chantar, María Luz, Inmunología, microbiología y parasitología, Immunologia, mikrobiologia eta parasitologia, Goikoetxea Usandizaga, Naroa, Serrano Maciá, Marina, Delgado, Teresa C., Simón Espinosa, Jorge, Fernández Ramos, David, Barriales, Diego, Cornide, María E., Jiménez, Mónica, Pérez Redondo, Marina, Lachiondo Ortega, Sofía, Rodríguez Agudo, Rubén, Bizkarguenaga, Maider, Diego Zalamea, Juan, Pasco, Samuel T., Caballero Díaz, Daniel, Alfano, Benedetta, Bravo Garmendia, Miren, González Recio, Irene, Mercado Gómez, María, Gil Pitarch, Clàudia, Mabe Alvarez, Jon, Gracia Sancho, Jordi, Abecia Aliende, Leticia, Lorenzo, Oscar, Martín Sanz, Paloma, Abrescia, Nicola A.G., Sabio, Guadalupe, Rincón, Mercedes, Anguita Castillo, Juan de Dios, Miñambres, Eduardo, Martín, César, Berenguer, Marina, Fabregat, Isabel, Casado, Marta, Peralta, Carmen, Varela Rey, Marta, and Martínez Chantar, María Luz

Abstract

[EN] Background and Aims Hepatic ischemia-reperfusion injury (IRI) is the leading cause of early posttransplantation organ failure as mitochondrial respiration and ATP production are affected. A shortage of donors has extended liver donor criteria, including aged or steatotic livers, which are more susceptible to IRI. Given the lack of an effective treatment and the extensive transplantation waitlist, we aimed at characterizing the effects of an accelerated mitochondrial activity by silencing methylation-controlled J protein (MCJ) in three preclinical models of IRI and liver regeneration, focusing on metabolically compromised animal models. Approach and Results Wild-type (WT), MCJ knockout (KO), and Mcj silenced WT mice were subjected to 70% partial hepatectomy (Phx), prolonged IRI, and 70% Phx with IRI. Old and young mice with metabolic syndrome were also subjected to these procedures. Expression of MCJ, an endogenous negative regulator of mitochondrial respiration, increases in preclinical models of Phx with or without vascular occlusion and in donor livers. Mice lacking MCJ initiate liver regeneration 12 h faster than WT and show reduced ischemic injury and increased survival. MCJ knockdown enables a mitochondrial adaptation that restores the bioenergetic supply for enhanced regeneration and prevents cell death after IRI. Mechanistically, increased ATP secretion facilitates the early activation of Kupffer cells and production of TNF, IL-6, and heparin-binding EGF, accelerating the priming phase and the progression through G(1)/S transition during liver regeneration. Therapeutic silencing of MCJ in 15-month-old mice and in mice fed a high-fat/high-fructose diet for 12 weeks improves mitochondrial respiration, reduces steatosis, and overcomes regenerative limitations. Conclusions Boosting mitochondrial activity by silencing MCJ could pave the way for a protective approach after major liver resection or IRI, especially in metabolically compromised, IRI-susceptible o

Published
2022

18. Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals

Author

Goikoetxea-Usandizaga, Naroa, Serrano-Maciá, Marina, Delgado, Teresa C., Simón, Jorge, Fernández-Ramos, David, Barriales, Diego, Cornide, Maria E., Jiménez, Mónica, Pérez-Redondo, Marina, Lachiondo-Ortega, Sofía, Rodríguez-Agudo, Rubén, Bizkarguenaga, Maider, Zalamea, Juan Diego, Pasco, Samuel T., Caballero-Díaz, Daniel, Alfano, Benedetta, Bravo, Miren, González-Recio, Irene, Mercado-Gomez, María, Gil-Pitarch, Clàudia, Mabe, Jon, Gracia-Sancho, Jordi, Abecia, Leticia, Lorenzo, Óscar, Martín-Sanz, Paloma, Abrescia, Nicola G. A., Sabio, Guadalupe, Rincón, Mercedes, Anguita, Juan, Miñambres, Eduardo, Martín, César, Berenguer, Marina, Fabregat, Isabel, Casado, Marta, Peralta, Carmen, Varela-Rey, Marta, Martínez-Chantar, María Luz, Goikoetxea-Usandizaga, Naroa, Serrano-Maciá, Marina, Delgado, Teresa C., Simón, Jorge, Fernández-Ramos, David, Barriales, Diego, Cornide, Maria E., Jiménez, Mónica, Pérez-Redondo, Marina, Lachiondo-Ortega, Sofía, Rodríguez-Agudo, Rubén, Bizkarguenaga, Maider, Zalamea, Juan Diego, Pasco, Samuel T., Caballero-Díaz, Daniel, Alfano, Benedetta, Bravo, Miren, González-Recio, Irene, Mercado-Gomez, María, Gil-Pitarch, Clàudia, Mabe, Jon, Gracia-Sancho, Jordi, Abecia, Leticia, Lorenzo, Óscar, Martín-Sanz, Paloma, Abrescia, Nicola G. A., Sabio, Guadalupe, Rincón, Mercedes, Anguita, Juan, Miñambres, Eduardo, Martín, César, Berenguer, Marina, Fabregat, Isabel, Casado, Marta, Peralta, Carmen, Varela-Rey, Marta, and Martínez-Chantar, María Luz

Abstract

[Background and aims ]Hepatic ischemia-reperfusion injury (IRI) is the leading cause of early posttransplantation organ failure as mitochondrial respiration and ATP production are affected. A shortage of donors has extended liver donor criteria, including aged or steatotic livers, which are more susceptible to IRI. Given the lack of an effective treatment and the extensive transplantation waitlist, we aimed at characterizing the effects of an accelerated mitochondrial activity by silencing methylation-controlled J protein (MCJ) in three preclinical models of IRI and liver regeneration, focusing on metabolically compromised animal models., [Approach and results] Wild-type (WT), MCJ knockout (KO), and Mcj silenced WT mice were subjected to 70% partial hepatectomy (Phx), prolonged IRI, and 70% Phx with IRI. Old and young mice with metabolic syndrome were also subjected to these procedures. Expression of MCJ, an endogenous negative regulator of mitochondrial respiration, increases in preclinical models of Phx with or without vascular occlusion and in donor livers. Mice lacking MCJ initiate liver regeneration 12 h faster than WT and show reduced ischemic injury and increased survival. MCJ knockdown enables a mitochondrial adaptation that restores the bioenergetic supply for enhanced regeneration and prevents cell death after IRI. Mechanistically, increased ATP secretion facilitates the early activation of Kupffer cells and production of TNF, IL-6, and heparin-binding EGF, accelerating the priming phase and the progression through G1 /S transition during liver regeneration. Therapeutic silencing of MCJ in 15-month-old mice and in mice fed a high-fat/high-fructose diet for 12 weeks improves mitochondrial respiration, reduces steatosis, and overcomes regenerative limitations., [Conclusions] Boosting mitochondrial activity by silencing MCJ could pave the way for a protective approach after major liver resection or IRI, especially in metabolically compromised, IRI-susceptible organs.

Published
2022

19. Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals

Author

Goikoetxea‐Usandizaga, Naroa, primary, Serrano‐Maciá, Marina, additional, Delgado, Teresa C., additional, Simón, Jorge, additional, Fernández Ramos, David, additional, Barriales, Diego, additional, Cornide, Maria E., additional, Jiménez, Mónica, additional, Pérez‐Redondo, Marina, additional, Lachiondo‐Ortega, Sofia, additional, Rodríguez‐Agudo, Rubén, additional, Bizkarguenaga, Maider, additional, Zalamea, Juan Diego, additional, Pasco, Samuel T., additional, Caballero‐Díaz, Daniel, additional, Alfano, Benedetta, additional, Bravo, Miren, additional, González‐Recio, Irene, additional, Mercado‐Gómez, Maria, additional, Gil‐Pitarch, Clàudia, additional, Mabe, Jon, additional, Gracia‐Sancho, Jordi, additional, Abecia, Leticia, additional, Lorenzo, Óscar, additional, Martín‐Sanz, Paloma, additional, Abrescia, Nicola G. A., additional, Sabio, Guadalupe, additional, Rincón, Mercedes, additional, Anguita, Juan, additional, Miñambres, Eduardo, additional, Martín, César, additional, Berenguer, Marina, additional, Fabregat, Isabel, additional, Casado, Marta, additional, Peralta, Carmen, additional, Varela‐Rey, Marta, additional, and Martínez‐Chantar, María Luz, additional

Published
2021
Full Text
View/download PDF

20. Interrupted versus continuous suture for bronchial anastomosis in lung transplantation: does it matter?

Author

Barturen, Mariana Gil, Cruz, Jose Luis Campo-Cañaveral de la, Carrasco, Silvana Crowley, Román, Alejandra Romero, Mejía, Lucas Hoyos, Peyró, María, Nuevo, Gema Díaz, García-Gallo, Cristina López, Redondo, Marina Pérez, Vicente, Ana Royuela, Tanaka, Shin, Gómez, Jose Manuel Naranjo, Peláez, Mar Córdoba, Ugarte, Andrés Varela de, and Antonio, David Gómez de

Subjects
LUNG transplantation, SURGICAL anastomosis, OPERATIVE surgery, HEART transplantation, SUTURES
Abstract

Open in new tab Download slide OBJECTIVES Bronchial anastomotic complications remain a major concern in lung transplantation. We aim to compare 2 different techniques, continuous suture (CS) versus interrupted suture (IS) by analysing airway complications requiring intervention. METHODS Lung transplantations between January 2015 and December 2020 were included. Airway complications requiring intervention were classified following the 2018 International Society for Heart and Lung Transplantation consensus and analysed comparing 3 groups of patients according to surgical technique: group A, both anastomosis performed with CS; group B, both with interrupted; and group C, IS for 1 side and CS for the contralateral side. RESULTS A total of 461 anastomoses were performed in 245 patients. The incidence of airway complications requiring intervention was 5.7% [95% confidence interval (CI): 2.8–8.6] per patient (14/245) and 3.7% (95% CI: 2.0–5.4) per anastomosis (17/461). Complications that required intervention were present in 5 out of 164 (3.1%) anastomosis with interrupted technique, and in 12/240 (5%) with CS. No significant differences were found between techniques (P  = 0.184). No statistical differences were found among group A, B or C in terms of incidence of anastomotic complications, demographics, transplant outcomes or overall survival (log-rank P  = 0.513). In a multivariable analysis, right laterality was significantly associated to complications requiring intervention (OR 3.7 [95% CI: 1.1–12.3], P  = 0.030). Endoscopic treatment was successful in 12 patients (85.7%). Retransplantation was necessary in 2 patients. CONCLUSIONS In summary, although it seems that anastomotic complications requiring intervention occur more frequently with CS, there are no statistical differences compared to IS. Endoscopic treatment offers good outcomes in most of the airway complications after lung transplantation. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

21. Lung transplantation from uncontrolled and controlled donation after circulatory death: similar outcomes to brain death donors

Author

Campo‐Cañaveral de la Cruz, Jose Luis, primary, Crowley Carrasco, Silvana, additional, Tanaka, Shin, additional, Romero Román, Alejandra, additional, Hoyos Mejía, Lucas, additional, Gil Barturen, Mariana, additional, Sánchez Calle, Álvaro, additional, García Fadul, Christian, additional, Aguilar Pérez, Myriam, additional, Pérez Redondo, Marina, additional, Naranjo Gómez, Jose Manuel, additional, Royuela, Ana, additional, Córdoba Peláez, Mar, additional, Varela de Ugarte, Andrés, additional, and Gómez de Antonio, David, additional

Published
2021
Full Text
View/download PDF

23. Economic Impact of Free Trade Agreements on the EU Agri-Food Sector

Author

Ferrari, Emanuele, Chatzopoulos, Thomas, Domínguez, Ignacio Pérez, Boulanger, Pierre, Boysen-Urban, Kirsten, Himics, Mihaly, M'barek, Robert, and Redondo, Marina Pinilla

Subjects
ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS, International Relations/Trade, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, Agribusiness, InformationSystems_MISCELLANEOUS
Abstract

Session ID 4714, Paper# 18430

Published
2021
Full Text
View/download PDF

24. Revisión bibliográfica acerca de la eficacia de la infiltración epidural en el tratamiento de la hernia discal lumbar

Author

León Redondo, Marina, Valverde García, José Antonio, Baticón Escudero, Pedro Miguel, and Universidad de Valladolid. Facultad de Medicina

Subjects
Infiltración epidural, Dolor radicular lumbosacro, 3207.14 Osteopatología
Abstract

El dolor radicular lumbosacro, conocido como ciática, es un síndrome que afecta a aquellos pacientes que refieren dolor irradiado a miembros inferiores,debido a una alteración en la raíz del nervio espinal. La causa más frecuente de este daño es la hernia discal lumbar.En cuanto a los tratamientos de la hernia discal lumbar, pueden ser, en primer lugar, MÉDICO que incluye fármacos, posibilidad de rehabilitación y tratamiento en la unidad del dolor, recomendándose las infiltraciones epidurales, y en segundo lugar, tratamiento QUIRÚRGICO.Las infiltraciones epidurales, en este caso de corticosteroides, consisten en la administración de estos en el espacio epidural, para reducir el proceso inflamatorio local que se produce alrededor del nervio y en consecuencia aliviar los síntomas. Hay tres tipos de vías, caudal, interlaminar y transforaminal,siendo estas dos últimas las más utilizadas. En la mayoría de los ensayos clínicos revisados, se encontró una evidencia de calidad moderada a favor dela infiltración de esteroides a nivel epidural., Grado en Medicina

Published
2021

25. Post-transplant outcomes of standard and extended criteria donation after circulatory death donor lungs categorized by donation after brain death lung criteria

Author

Tanaka, Shin, primary, Campo-Cañaveral de la Cruz, Jose Luis, additional, Barturen, Mariana Gil, additional, Carrasco, Silvana Crowley, additional, Román, Alejandra Romero, additional, León, María Trujillo Sánchez de, additional, Mejía, Lucas Hoyos, additional, Gómez, Jose Manuel Naranjo, additional, Peláez, Mar Córdoba, additional, Calle, Álvaro Sánchez, additional, Redondo, Marina Pérez, additional, Fadul, Christian García, additional, Ugarte, Andrés Varela de, additional, and de-Antonio, David Gómez-, additional

Published
2021
Full Text
View/download PDF

26. The Premonitory Urge for Tics Scale in a large sample of children and adolescents:psychometric properties in a developmental context. An EMTICS study

Author

Openneer, Thaïra J.C., Tárnok, Zsanett, Bognar, Emese, Benaroya-Milshtein, Noa, Garcia-Delgar, Blanca, Morer, Astrid, Steinberg, Tamar, Hoekstra, Pieter J., Dietrich, Andrea, Apter, Alan, Baglioni, Valentina, Ball, Juliane, Bodmer, Benjamin, Burger, Bianka, Buse, Judith, Cardona, Francesco, Correa Vela, Marta, Debes, Nanette M., Ferro, Maria Cristina, Fremer, Carolin, Gulisano, Mariangela, Hagen, Annelieke, Hagstrøm, Julie, Hedderly, Tammy J., Heyman, Isobel, Huyser, Chaim, Madruga-Garrido, Marcos, Marotta, Anna, Mir, Pablo, Müller, Norbert, Müller-Vahl, Kirsten, Münchau, Alexander, Nagy, Peter, Neri, Valeria, Pellico, Alessandra, Plessen, Kerstin J., Porcelli, Cesare, Redondo, Marina, Rizzo, Renata, Roessner, Veit, Ruhrman, Daphna, Schnell, Jaana M.L., Silvestri, Paola Rosaria, Skov, Liselotte, Tagwerker Gloor, Friederike, Tübing, Jennifer, Turner, Victoria L., Visscher, Frank, and the EMTICS collaborative group, Apter, A., Baglioni, V., Ball, J., Benaroya-Milshtein, N., Bodmer, B., Bognar, E., Burger, B., Buse, J., Cardona, F., Correa Vela, M., Debes, N.M., Dietrich, A., Ferro, M.C., Fremer, C., Garcia-Delgar, B., Gulisano, M., Hagen, A., Hagstrøm, J., Hedderly, T.J., Heyman, I., Hoekstra, P.J., Huyser, C., Madruga-Garrido, M., Marotta, A., Mir, P., Morer, A., Müller, N., Müller-Vahl, K., Münchau, A., Nagy, P., Neri, V., Openneer, TJC, Pellico, A., Plessen, K.J., Porcelli, C., Redondo, M., Rizzo, R., Roessner, V., Ruhrman, D., Schnell, JML, Silvestri, P.R., Skov, L., Steinberg, T., Tagwerker Gloor, F., Tárnok, Z., Tübing, J., Turner, V.L., Visscher, F., ANS - Cellular & Molecular Mechanisms, Child Psychiatry, ANS - Amsterdam Neuroscience, and Clinical Cognitive Neuropsychiatry Research Program (CCNP)

Subjects
Sensory phenomena, Male, Tourette syndrome, THERAPY, Severity of Illness Index, Obsessive-compulsive symptoms, 0302 clinical medicine, Quality of life, QUALITY-OF-LIFE, Developmental and Educational Psychology, Child and adolescent psychiatry, 030212 general & internal medicine, ADULT PATIENTS, Child, Premonitory Urge for Tics Scale (PUTS), Obsessive–compulsive symptoms, Premonitory urges, Psychometric properties, General Medicine, Original Contribution, Psychiatry and Mental health, Child, Preschool, Female, medicine.symptom, Psychology, Clinical psychology, medicine.medical_specialty, Tics, Adolescent, Psychometrics, DISORDERS, QUESTIONNAIRE, Context (language use), 03 medical and health sciences, OBSESSIVE-COMPULSIVE SCALE, medicine, SENSORY PHENOMENA, Humans, TOURETTE-SYNDROME, HABIT REVERSAL, Reproducibility of Results, medicine.disease, SEVERITY, Sample size determination, Tic Disorders, Pediatrics, Perinatology and Child Health, Chronic Tic Disorder, 030217 neurology & neurosurgery
Abstract

Premonitory urges are uncomfortable physical sensations preceding tics that occur in most individuals with a chronic tic disorder. The Premonitory Urge for Tics Scale (PUTS) is the most frequently used self-report measure to assess the severity of premonitory urges. We aimed to evaluate the psychometric properties of the PUTS in the largest sample size to date (n = 656), in children aged 3–16 years, from the baseline measurement of the longitudinal European Multicenter Tics in Children Study (EMTICS). Our psychometric evaluation was done in three age-groups: children aged 3–7 years (n = 103), children between 8 and 10 years (n = 253), and children aged 11–16 years (n = 300). The PUTS exhibited good internal reliability in children and adolescents, also under the age of 10, which is younger than previously thought. We observed significant but small correlations between the severity of urges and severity of tics and obsessive–compulsive symptoms, and between severity of urges and ratings of attention-deficit/hyperactivity disorder and internalizing and externalizing behaviors, however, only in children of 8–10 years. Consistent with previous results, the 10th item of the PUTS correlated less with the rest of the scale compared to the other items and, therefore, should not be used as part of the questionnaire. We found a two-factor structure of the PUTS in children of 11 years and older, distinguishing between sensory phenomena related to tics, and mental phenomena as often found in obsessive–compulsive disorder. The age-related differences observed in this study may indicate the need for the development of an age-specific questionnaire to assess premonitory urges. Electronic supplementary material The online version of this article (10.1007/s00787-019-01450-1) contains supplementary material, which is available to authorized users.

Published
2020

27. Effect on the donor lungs of using abdominal normothermic regional perfusion in controlled donation after circulatory death

Author

Tanaka, Shin, primary, Luis Campo-Cañaveral de la Cruz, Jose, additional, Crowley Carrasco, Silvana, additional, Romero Román, Alejandra, additional, Hoyos Mejía, Lucas, additional, Manuel NaranjoGómez, Jose, additional, Córdoba Peláez, Mar, additional, Sánchez Calle, Álvaro, additional, Gil Barturen, Mariana, additional, Pérez Redondo, Marina, additional, García Fadul, Christian, additional, Varela de Ugarte, Andrés, additional, and Gómez-de-Antonio, David, additional

Published
2020
Full Text
View/download PDF

28. Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals.

Author

Goikoetxea‐Usandizaga, Naroa, Serrano‐Maciá, Marina, Delgado, Teresa C., Simón, Jorge, Fernández Ramos, David, Barriales, Diego, Cornide, Maria E., Jiménez, Mónica, Pérez‐Redondo, Marina, Lachiondo‐Ortega, Sofia, Rodríguez‐Agudo, Rubén, Bizkarguenaga, Maider, Zalamea, Juan Diego, Pasco, Samuel T., Caballero‐Díaz, Daniel, Alfano, Benedetta, Bravo, Miren, González‐Recio, Irene, Mercado‐Gómez, Maria, and Gil‐Pitarch, Clàudia

Published
2022
Full Text
View/download PDF

29. Antibodies to neuronal surface proteins in Tourette Syndrome: Lack of evidence in a European paediatric cohort

Author

Anastasiou, Zacharias, Apter, Alan, Bartolini, Erika, Benaroya-Milshtein, Noa, Bodmer, Benjamin, Bognar, Emese, Burger, Bianka, Correa Vela, Marta, Creti, Roberta, Dietrich, Andrea, Debes, Nanette M., Efstratiou, Androulla, Cristina Ferro, Maria, Fremer, Carolin, Garcia-Delgar, Blanca, Gariup, Maria, Georgitsi, Marianthi, Gulisano, Mariangela, Hagen, Annelieke, Hagstrøm, Julie, Hedderly, Tammy J., Heyman, Isobel, Hoekstra, Pieter J., Huyser, Chaim, Imperi, Monica, Karagiannidis, Iordanis, Laviola, Giovanni, Macri, Simone, Madruga-Garrido, Marcos, Margarit, Immaculada, Marotta, Anna, Martino, Davide, Meier, Ute C., Mir, Pablo, Moll, Natalie, Morer, Astrid, Müller-Vahl, Kirsten, Münchau, Alexander, Nagy, Peter, Neri, Valeria, Openneer, Thaïra J.C., Orefici, Graziella, Paschou, Peristera, Pellico, Alessandra, Porcelli, Cesare, Redondo, Marina, Rizzo, Renata, Roazzi, Paolo, Roessner, Veit, Ruhrman, Daphna, Schnell, Jaana M.L., Schrag, Anette, Schütze, Gregor A., Schwarz, Markus J., Rosaria Silvestri, Paola, Skov, Liselotte, Steinberg, Tamar, Stöber, Sara, Tallon, Marco, Tarnok, Zsanett, Baglioni, V., Coutinho, E., Menassa, D.A., Giannoccaro, M.P., Jacobson, L., Buttiglione, M., Petruzzelli, O., Cardona, F., and Vincent, A.

Published
2019
Full Text
View/download PDF

30. Transplantation of a Heart Donated After Circulatory Death via Thoraco-Abdominal Normothermic Regional Perfusion.&nbsp;Results from the first Spanish case.&nbsp;

Author

Redondo, Marina Pérez, primary, Carmona, Sara Alcántara, additional, García, Susana Villar, additional, Gil, Alberto Forteza, additional, Fernández, Hector Villanueva, additional, Hernández-Pérez, Francisco José, additional, Cruz, Jose Luis Campo-Cañaveral de la, additional, Calvo, Rocío Velasco, additional, Segovia-Cubero, Javier, additional, Menárguez, Beatriz Alonso, additional, Gallegos, Francisco del Río, additional, Coll, Elisabeth, additional, Gonzalez, Beatriz Domínguez-Gil, additional, and Muñoz, Juan José Rubio, additional

Published
2020
Full Text
View/download PDF

31. Transplantation of a Heart Donated After Circulatory Death via Thoraco-Abdominal Normothermic Regional Perfusion. Results from the first Spanish case.

Author

Redondo, Marina Pérez, primary, Carmona, Sara Alcántara, additional, García, Susana Villar, additional, Gil, Alberto Forteza, additional, Fernández, Hector Villanueva, additional, Hernández-Pérez, Francisco José, additional, Cruz, Jose Luis Campo-Cañaveral de la, additional, Calvo, Rocío Velasco, additional, Segovia-Cubero, Javier, additional, Menárguez, Beatriz Alonso, additional, Gallegos, Francisco del Río, additional, Coll, Elisabeth, additional, Gonzalez, Beatriz Domínguez-Gil, additional, and Muñoz, Juan José Rubio, additional

Published
2020
Full Text
View/download PDF

32. Implementation of a mobile team to provide normothermic regional perfusion in controlled donation after circulatory death: Pilot study and first results

Author

Pérez Redondo, Marina, primary, Alcántara Carmona, Sara, additional, Fernández Simón, Inmaculada, additional, Villanueva Fernández, Héctor, additional, Ortega López, Alfonso, additional, Pardo Rey, Cándido, additional, Duerto Álvarez, Jorge, additional, Lipperheide Vallhonrat, Inés, additional, González Romero, Manuel, additional, Ballesteros Ortega, Daniel, additional, Río Gallegos, Francisco, additional, and Rubio Muñoz, Juan José, additional

Published
2020
Full Text
View/download PDF

33. MCJ: A therapeutic target in hepatic ischemia and reperfusion injury

Author

Goikoetxea-Usandizaga, Naroa, Fernández-Ramos, David, Serrano-Maciá, Marina, Eugenia Cornide, Maria, Jimenez-Castro, Monica, Alfano, Bennedetta, Sáenz de Urturi, Diego, Gonzalez-Romero, Francisco, Gutiérrez de Juan, Virginia, Rodríguez-Iruretagoyena, Begoña, Cardoso Delgado, Teresa, Lopitz-Otsoa, Fernando, Barbier Torres, Lucia, Fernández-Tussy, Pablo, Simón, Jorge, Martín, Paloma, Anguita, Juan, Perez Redondo, Marina, Miñambres, Eduardo, Lu, Shelly C., Mato, José M., Sabio, Guadalupe, Peralta, Carmen, Aspichueta, Patricia, Casado, Marta, Martín, César, Varela-Rey, Marta, and Martínez-Chantar, María Luz

Abstract

Trabajo presentado en The International Liver Congress, celebrado en Viena (Austria) del 10 al 14 de abril de 2019., [Background and aims]: Ischemia/reperfusion (IR) injury, a frequent pathological process during liver resection, is a leading cause of post transplantation organ dysfunction. The extent of the injury can determine the success of the procedure and the survival of the patient. Therefore, attenuation of pathology caused by the injury and improving liver function after the procedure would be critical for clinicians to diminish IR injury prevalence and improve the outcome. Mitochondria play a key role in liver homeostasis; indeed, more functional mitochondria induce hepatic regeneration. MCJ, also known as DNACJ15, is an endogenous negative regulator of complex I, located in the mitochondrial electron transport chain. While under normal conditions MCJ deficiency does not result in an altered phenotype in mice, its absence improves mitochondrial activity without increasing mitochondrial ROS. We present MCJ as a new target to minimize hepatic damage caused by IR injury and enhance the efficiency of liver regeneration during liver resection., [Method]: Partial hepatectomies (PH) and PH combined with IR injuries were performed in MCJ-KO mice and in WT mice after MCJ silencing., [Results]: We observed that the lack of MCJ reduced liver damage and induced hepatic regeneration after IR injury; MCJ-KO mice showed lower levels of Caspase 3 and a significantly higher Cyclin D1 expression. Moreover, we saw an improved metabolic response to hepatic insufficiency and an accelerated cell cycle progression during liver resection, which led to a faster recovery of the hepatic mass. In the initial phase after the PH, glucagon response was amplified in MCJ-KO mice, characterized by increased cAMP and AKT signaling, along with higher Ca+2 release from the endoplasmic reticulum (ER), glycogen synthase kinase (GSK-3beta) inhibition and nuclear factorKbeta (NFKbeta) translocation to the nucleus. In the proliferative phase, ablation of MCJ accelerated the induction of proliferative markers. Indeed, after MCJ silencing, an improved phenotype was detected in an aging mice model that underwent partial hepatectomy. Hepatic insufficiency was ameliorated, PCNA expression increased and steatosis reverted. Importantly, the combined procedure of PH and IR injury that resemble liver transplant procedure resulted in a 100% survival rate for MCJ-KO mice while just the 33% of MCJ-WT mice survived the operation. Increased levels of MCJ were found in liver biopsies from all liver donors at 60 minutes after normothermic regional perfusion (nRP) was started., [Conclusion]: Overall, MCJ silencing during liver resection emerges as a promising therapy for IR injury and restoration of hepatic mass.

Published
2019

34. Mindfulness en las aulas: estudio sobre su influencia en la capacidad atencional del alumnado de Bachillerato

Author

Melià Redondo, Marina, Aguirre Garcia-Carpintero, Arecia, and Universitat Jaume I. Departament de Pedagogia i Didàctica de les Ciències Socials, la Llengua i la Literatura

Subjects
rendimiento académico, concentration, Máster Universitario en Profesor/a de Educación Secundaria Obligatoria y Bachillerato, Formación Profesional y Enseñanzas de Idiomas, students, Master's Degree in Secondary Education, Vocational Training and Language Teaching, educación secundaria, academic performance, atención, Màster Universitari en Professor/a d'Educació Secundària Obligatòria i Batxillerat, Formació Professional i Ensenyaments d'Idiomes, mindfullness, concentración, attention, actitud, atención plena, relaxation, alumnado, attitude, secondary education, estudiantes, relajación
Abstract

Treball Final de Màster Universitari en Professor/a d'Educació Secundària Obligatòria i Batxillerat, Formació Professional i Ensenyaments d'Idiomes. Codi SAP139. Curs: 2017/2018 Se entiende por mindfulness el prestar atención de forma deliberada, en el momento presente y sin juzgar. El objetivo de este trabajo es valorar los posibles cambios en la capacidad atencional del alumnado de 1º de Bachiller, antes y después de la aplicación de un programa mindfulness, en la asignatura de Biología, a través de un análisis comparativo. Para ello se realiza una investigación educativa caracterizada por la combinación de métodos cualitativos y cuantitativos, junto con una fundamentación que avala la incorporación del mindfulness en el contexto educativo. Los niveles atencionales del grupo de estudio se evalúan mediante instrumentos cuantitativos y cualitativos de recogida de datos. El análisis de los valores estadísticos obtenidos muestran un incremento significativo en los valores atencionales del grupo experimental y mejoras en la concentración, atención y bienestar en el alumnado, así como una disminución del estrés. Los resultados hallados confirman la utilidad de las técnicas de conciencia plena como estrategias útiles y efectivas para mejorar la capacidad atencional, y suponen un apoyo empírico para su incorporación y utilización en el ámbito educativo Mindfulness means to pay attention deliberately, in the present moment and without judgment. The objective of this work is to assess the possible changes in the attention capacity of 1st of Bachelor students, before and after the application of a mindfulness program, in the subject of Biology, through a comparative analysis. To this end, a rigorous educational research is carried out characterized by the combination of qualitative and quantitative methods, together with a theoretical foundation that supports the incorporation of mindfulness in the educational context. The attention levels of the study group are evaluated through different quantitative and qualitative data collection instruments. The analysis of the statisticians showed a significant increase in the attentional values of the experimental group and improvements in concentration, attention and well-being in the students, as well as a decrease in stress. The results found confirm the usefulness of the techniques of full consciousness as useful and effective strategies to improve the attentional capacity and suppose an empirical support for their incorporation and use in the educational field

Published
2018

35. Characteristics and outcome of patients with solid tumour requiring admission to the intensive care unit. Usefulness of three severity score systems

Author

Pérez Pérez, María Lucía, primary, Gonzaga López, Ana, additional, Balandín Moreno, Bárbara, additional, Maximiano Alonso, Constanza, additional, Palacios Castañeda, Diego, additional, Ferreres Franco, José, additional, García Sanz, Javier, additional, Villanueva Fernández, Héctor, additional, Valdivia de la Fuente, Miguel, additional, Ortega López, Alfonso, additional, Alcántara Carmona, Sara, additional, Pérez Redondo, Marina, additional, and Royuela Vicente, Ana, additional

Published
2019
Full Text
View/download PDF

36. Antibodies to neuronal surface proteins in Tourette Syndrome: Lack of evidence in a European paediatric cohort

Author

Baglioni, V., primary, Coutinho, E., additional, Menassa, D.A., additional, Giannoccaro, M.P., additional, Jacobson, L., additional, Buttiglione, M., additional, Petruzzelli, O., additional, Cardona, F., additional, Vincent, A., additional, Anastasiou, Zacharias, additional, Apter, Alan, additional, Bartolini, Erika, additional, Benaroya-Milshtein, Noa, additional, Bodmer, Benjamin, additional, Bognar, Emese, additional, Burger, Bianka, additional, Correa Vela, Marta, additional, Creti, Roberta, additional, Dietrich, Andrea, additional, Debes, Nanette M., additional, Efstratiou, Androulla, additional, Cristina Ferro, Maria, additional, Fremer, Carolin, additional, Garcia-Delgar, Blanca, additional, Gariup, Maria, additional, Georgitsi, Marianthi, additional, Gulisano, Mariangela, additional, Hagen, Annelieke, additional, Hagstrøm, Julie, additional, Hedderly, Tammy J., additional, Heyman, Isobel, additional, Hoekstra, Pieter J., additional, Huyser, Chaim, additional, Imperi, Monica, additional, Karagiannidis, Iordanis, additional, Laviola, Giovanni, additional, Macri, Simone, additional, Madruga-Garrido, Marcos, additional, Margarit, Immaculada, additional, Marotta, Anna, additional, Martino, Davide, additional, Meier, Ute C., additional, Mir, Pablo, additional, Moll, Natalie, additional, Morer, Astrid, additional, Müller-Vahl, Kirsten, additional, Münchau, Alexander, additional, Nagy, Peter, additional, Neri, Valeria, additional, Openneer, Thaïra J.C., additional, Orefici, Graziella, additional, Paschou, Peristera, additional, Pellico, Alessandra, additional, Porcelli, Cesare, additional, Redondo, Marina, additional, Rizzo, Renata, additional, Roazzi, Paolo, additional, Roessner, Veit, additional, Ruhrman, Daphna, additional, Schnell, Jaana M.L., additional, Schrag, Anette, additional, Schütze, Gregor A., additional, Schwarz, Markus J., additional, Rosaria Silvestri, Paola, additional, Skov, Liselotte, additional, Steinberg, Tamar, additional, Stöber, Sara, additional, Tallon, Marco, additional, and Tarnok, Zsanett, additional

Published
2019
Full Text
View/download PDF

37. PS-034-MCJ: A therapeutic target in hepatic ischemia and reperfusion injury

Author

Goikoetxea, Naroa, primary, Ramos, David Fernández, additional, Serrano-Macia, Marina, additional, Cornide, Maria Eugenia, additional, Jiménez-Castro, Mónica, additional, Alfano, Bennedetta, additional, Urturi, Diego Saenz de, additional, Gonzalez-Romero, Francisco, additional, de Juan, Virginia Gutiérrez, additional, Iruretagoyena, Begoña Rodriguez, additional, Delgado, Teresa Cardoso, additional, Otsoa, Fernando Lopitz, additional, Torres, Lucía Barbier, additional, Tussy, Pablo Fernández, additional, Simón, Jorge, additional, Martín, Paloma, additional, Anguita, Juan, additional, Redondo, Marina Perez, additional, Miñambres, Eduardo, additional, Lu, Shelly C., additional, Mato, José M., additional, Sabio, Guadalupe, additional, Peralta, Carmen, additional, Aspichueta, Patricia, additional, Casado, Marta, additional, Martin, Cesar, additional, Varela-Rey, Marta, additional, and Martínez-Chantar, María Luz, additional

Published
2019
Full Text
View/download PDF

38. Effect on the donor lungs of using abdominal normothermic regional perfusion in controlled donation after circulatory death.

Author

Tanaka, Shin, Cruz, Jose Luis Campo-Cañaveral de la, Carrasco, Silvana Crowley, Román, Alejandra Romero, Mejía, Lucas Hoyos, NaranjoGómez, Jose Manuel, Peláez, Mar Córdoba, Calle, Álvaro Sánchez, Barturen, Mariana Gil, Redondo, Marina Pérez, Fadul, Christian García, Ugarte, Andrés Varela de, and Gómez-de-Antonio, David

Subjects
ISOLATION perfusion, LUNGS, LUNG transplantation, TRANSPLANTATION of organs, tissues, etc., HOSPITAL mortality, BK virus, REPERFUSION injury
Abstract

Open in new tab Download slide Open in new tab Download slide OBJECTIVES Controlled donation after circulatory death (cDCD) donors are becoming a common source of organs for transplantation globally. However, the graft survival rate of cDCD abdominal organs is inferior to that of organs from brain-dead donors. The rapid retrieval (RR) technique is used by most donor organ procurement teams. The abdominal normothermic regional perfusion (A-NRP) technique has been implemented to minimize warm ischaemic damage to the abdominal organs. However, there is limited information on the effect of A-NRP on the quality of the donor lungs. This study aimed to compare lung transplantation outcomes using lungs procured from cDCD donors using the A-NRP and abdominal RR techniques. METHODS A single-centre retrospective analysis of consecutive transplant recipients of cDCD lungs from June 2013 to December 2019 was performed. The recipients were divided into 2 cohorts according to the abdominal procurement technique used. The recipient and donor characteristics (age, sex, cause of brain injury, warm ischaemic time, diagnosis, lung allocation score and other factors), incidence of primary graft dysfunction and early survival were monitored. RESULTS Twenty-eight consecutive lung transplantation recipients were identified (median age 59 years; 61% male); 14 recipients received lungs using the A-NRP and 14 using abdominal RR for abdominal organ retrieval. There were no significant differences in the baseline characteristics, primary graft dysfunction (P  =   0.70), hospital mortality (P  =   1.0) and 1-year survival rate (P  =   1.0) between the 2 groups. CONCLUSIONS No difference was observed in lung transplantation outcomes irrespective of the abdominal organ procurement technique used (A-NRP or abdominal RR). [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

39. Local low-dose urokinase thrombolysis for the management of haemodynamically stable pulmonary embolism with right ventricular dysfunction

Author

Alcántara Carmona, Sara, primary, Pérez Redondo, Marina, additional, Nombela Franco, Luis, additional, González Costero, Rocío, additional, Balandín Moreno, Bárbara, additional, Valdivia de la Fuente, Miguel, additional, Méndez Alonso, Santiago, additional, García Suárez, Agustín, additional, and Royuela, Ana, additional

Published
2018
Full Text
View/download PDF

47. Association of SARS-CoV-2 immunoserology and vaccination status with myocardial infarction severity and outcome.

Author

Blasco A, Royuela A, García-Gómez S, Gómez-Lozano N, Sánchez-Arjona A, de la Fuente J, Anel J, Sánchez-Galarraga I, Pérez-Redondo M, González E, and Silva L

Abstract

Background: The COVID-19 pandemic adversely affected the severity and prognosis of patients with acute myocardial infarction (MI) caused by atherothrombosis (type 1 MI). The effect, if any, of COVID-19 vaccination and natural SARS-CoV2 serologic immunity in these patients is unclear. Our aim was to analyze the association between the severity and outcome of patients with type 1 MI and their previous SARS-CoV2 vaccination and serostatus., Methods: A single-center retrospective cohort study conducted between March 1, 2020 and March 1, 2023. Clinical and follow-up information was collected from medical records and patients. Total antibodies (IgM, IgA, IgG) to nucleocapsid (N) antigens were measured by ECLIA (electrochemiluminescence-based immunoassay) to test the immune response to natural infection. If positive, IgM and IgG antibodies to spike (S) surface antigens were measured by CLIA to test the immune response to vaccine or natural infection. Multivariable logistic regression analysis was performed, adjusting for age, sex, hypertension, diabetes, and dyslipidemia., Results: Total sample of 949 patients, 656 with ST-segment elevation MI (STEMI) and 293 with non-ST-segment elevation MI (NSTEMI). Mean age was 64 (SD 13) years, 80 % men. Pre-admission vaccination status was: ≥ 1 dose, 53 % of patients; complete vaccination, 49 %; first booster dose, 25 %. The majority (84 %) of vaccines administered were mRNA-based. Six months after MI, 92 (9.7 %) patients had a major adverse cardiac event (MACE) and 50 died; 11 % of patients had severe heart failure or cardiogenic shock (Killip III-IV) after STEMI. Vaccinated patients with STEMI and positive serology (Pos/Vax group) had a higher risk of Killip III-IV on admission: OR 2.63 (1.27-5.44), p = 0.010. SARS-CoV-2 S-specific IgG titers were highest in this group (median > 2080 AU/mL, [IQR 1560- >2080] vs 91 [32-198] in the unvaccinated group). In the overall sample, a higher incidence of 6-month MACE was not demonstrated (OR 1.89 [0.98-3.61], p = 0.055)., Conclusions: The combination of vaccination and natural SARS-CoV2 infection was associated with the development of severe heart failure and cardiogenic shock in patients with STEMI, possibly related to an increased serological response., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: ANA BLASCO reports article publishing charges was provided by the Foundation for Biomedical Research of the Hospital Universitario Puerta de Hierro Majadahonda. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results