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2,550 results on '"Reddy, P. S."'

10. Meta-analysis of genome-wide association studies for cancer therapy-related cardiovascular dysfunction and functional mapping highlight an intergenic region close to TP63

Author

Martínez-Campelo, L., Blanco-Verea, A., López-Fernández, T., Martínez-Monzonís, A., Buño, A., Mazón, P., Zamora, P., Norton, N., Reddy, J. S., Velasco-Ruiz, A., González-Neira, A., Vulsteke, C., Alonso-Gordoa, T., Cruz, R., Diz-de Almeida, S., Carracedo, A., González-Juanatey, JR., López-Sendón, J., and Brion, M.

Published
2024
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11. Gliovascular transcriptional perturbations in Alzheimer’s disease reveal molecular mechanisms of blood brain barrier dysfunction

Author

İş, Özkan, Wang, Xue, Reddy, Joseph S., Min, Yuhao, Yilmaz, Elanur, Bhattarai, Prabesh, Patel, Tulsi, Bergman, Jeremiah, Quicksall, Zachary, Heckman, Michael G., Tutor-New, Frederick Q., Can Demirdogen, Birsen, White, Launia, Koga, Shunsuke, Krause, Vincent, Inoue, Yasuteru, Kanekiyo, Takahisa, Cosacak, Mehmet Ilyas, Nelson, Nastasia, Lee, Annie J., Vardarajan, Badri, Mayeux, Richard, Kouri, Naomi, Deniz, Kaancan, Carnwath, Troy, Oatman, Stephanie R., Lewis-Tuffin, Laura J., Nguyen, Thuy, Carrasquillo, Minerva M., Graff-Radford, Jonathan, Petersen, Ronald C., Jr Jack, Clifford R., Kantarci, Kejal, Murray, Melissa E., Nho, Kwangsik, Saykin, Andrew J., Dickson, Dennis W., Kizil, Caghan, Allen, Mariet, and Ertekin-Taner, Nilüfer

Published
2024
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20. Impact of Covid-19 Pandemic on Water Pollution in Indian Rivers -- A Case Study

Author

Mahadikar, Amardeepak, Anand, Krishna, and Reddy, Chandra S.

Subjects
Physics - Physics and Society
Abstract

Some of the important critical parameters for assessing the water quality like pH (Hydrogen ion concentration), DO (Dissolved Oxygen), BOD (Biological Oxygen Demand), etc., were monitored at different locations in some major Indian rivers. The results obtained from the study reveals that the critical parameters had increasing values in some monitoring locations, decreasing values, and no variation in values at some other places. It is recommended to have a pH value above 7, higher values of DO, lower values of BOD & FCC (Faecal Coliform Content) for improved water quality. Overall, the water quality improved in most Indian rivers. There was no discharge of industrial wastes, hotels/restaurants wastes, immersing of idols during religious festivals, etc., to the rivers during the COVID-19 lockdown. Therefore, enforcement of strict regulations by the Government of India for disposal of wastes produced from industrial & domestic activities can significantly reduce the water pollution levels in the Indian rivers., Comment: 5 pages, 7 figures, 8 tables

Published
2023
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26. Evaluation of the Efficacy of Neo-endo, Hyflex Re-treatment File Systems and H-Files for Removing Gutta-Percha From Root Canal Treated Tooth by Using Stereomicroscope—An In Vitro Study

Author

Karunakar P, Ranga Reddy M S, Karteek Basa Srinivas, Lakshmi Charan Reddy Chavva, Swetha Chigurupati, Racha Kundana, and Waheed Sumaiya

Subjects
h-files, hyflex™, neo-endo, pro-taper universal, retreatment, Pharmacy and materia medica, RS1-441, Analytical chemistry, QD71-142
Abstract

AimTo evaluate the efficacy of Neo-endo, Hyflextm retreatment file systems, and H-files for removing gutta-percha from root canal treated tooth. Materials and MethodsThirty extracted single-rooted human teeth with a single canal were opted. The shaping of the root canals was done with pro-taper universal files and later obturated. The samples were grouped based on the file system chosen for removing the obturating material: Group I-H-files; Group II-Neo-endo retreatment files; Group III-Hyflex™ retreatment files. The quantity of remaining gutta-percha still present after the retreatment procedure was assessed under a stereomicroscope. One-way Analysis of Variance (ANOVA) was used to statistically analyze the data. ResultsHyflex™ files left less remaining filling material than with Neo-endo and H-files. ConclusionThe Hyflex™ retreatment files were most efficient in removing the gutta-percha from the root canal.

Published
2024
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31. Cross species systems biology discovers glial DDR2, STOM, and KANK2 as therapeutic targets in progressive supranuclear palsy

Author

Min, Yuhao, Wang, Xue, İş, Özkan, Patel, Tulsi A., Gao, Junli, Reddy, Joseph S., Quicksall, Zachary S., Nguyen, Thuy, Lin, Shu, Tutor-New, Frederick Q., Chalk, Jessica L., Mitchell, Adriana O., Crook, Julia E., Nelson, Peter T., Van Eldik, Linda J., Golde, Todd E., Carrasquillo, Minerva M., Dickson, Dennis W., Zhang, Ke, Allen, Mariet, and Ertekin-Taner, Nilüfer

Published
2023
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33. Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder

Author

Bauer, Michael, Glenn, Tasha, Achtyes, Eric D., Alda, Martin, Agaoglu, Esen, Altınbaş, Kürsat, Andreassen, Ole A., Angelopoulos, Elias, Ardau, Raffaella, Aydin, Memduha, Ayhan, Yavuz, Baethge, Christopher, Bauer, Rita, Baune, Bernhard T., Balaban, Ceylan, Becerra-Palars, Claudia, Behere, Aniruddh P., Behere, Prakash B., Belete, Habte, Belete, Tilahun, Belizario, Gabriel Okawa, Bellivier, Frank, Belmaker, Robert H., Benedetti, Francesco, Berk, Michael, Bersudsky, Yuly, Bicakci, Şule, Birabwa-Oketcho, Harriet, Bjella, Thomas D., Brady, Conan, Cabrera, Jorge, Cappucciati, Marco, Castro, Angela Marianne Paredes, Chen, Wei-Ling, Cheung, Eric Y. W., Chiesa, Silvia, Crowe, Marie, Cuomo, Alessandro, Dallaspezia, Sara, Del Zompo, Maria, Desai, Pratikkumar, Dodd, Seetal, Etain, Bruno, Fagiolini, Andrea, Fellendorf, Frederike T., Ferensztajn-Rochowiak, Ewa, Fiedorowicz, Jess G., Fountoulakis, Kostas N., Frye, Mark A., Geoffroy, Pierre A., Gitlin, Michael J., Gonzalez-Pinto, Ana, Gottlieb, John F., Grof, Paul, Haarman, Bartholomeus C. M., Harima, Hirohiko, Hasse-Sousa, Mathias, Henry, Chantal, Hoffding, Lone, Houenou, Josselin, Imbesi, Massimiliano, Isometsä, Erkki T., Ivkovic, Maja, Janno, Sven, Johnsen, Simon, Kapczinski, Flávio, Karakatsoulis, Gregory N., Kardell, Mathias, Kessing, Lars Vedel, Kim, Seong Jae, König, Barbara, Kot, Timur L., Koval, Michael, Kunz, Mauricio, Lafer, Beny, Landén, Mikael, Larsen, Erik R., Lenger, Melanie, Licht, Rasmus W., Lopez-Jaramillo, Carlos, MacKenzie, Alan, Madsen, Helle Østergaard, Madsen, Simone Alberte Kongstad A., Mahadevan, Jayant, Mahardika, Agustine, Manchia, Mirko, Marsh, Wendy, Martinez-Cengotitabengoa, Monica, Martini, Julia, Martiny, Klaus, Mashima, Yuki, McLoughlin, Declan M., Meesters, Ybe, Melle, Ingrid, Meza-Urzúa, Fátima, Mikolas, Pavol, Mok, Yee Ming, Monteith, Scott, Moorthy, Muthukumaran, Morken, Gunnar, Mosca, Enrica, Mozzhegorov, Anton A., Munoz, Rodrigo, Mythri, Starlin V., Nacef, Fethi, Nadella, Ravi K., Nakanotani, Takako, Nielsen, René Ernst, O’Donovan, Claire, Omrani, Adel, Osher, Yamima, Ouali, Uta, Pantovic-Stefanovic, Maja, Pariwatcharakul, Pornjira, Petite, Joanne, Petzold, Johannes, Pfennig, Andrea, Ruiz, Yolanda Pica, Pinna, Marco, Pompili, Maurizio, Porter, Richard J., Quiroz, Danilo, Rabelo-da-Ponte, Francisco Diego, Ramesar, Raj, Rasgon, Natalie, Ratta-apha, Woraphat, Ratzenhofer, Michaela, Redahan, Maria, Reddy, M. S., Reif, Andreas, Reininghaus, Eva Z., Richards, Jenny Gringer, Ritter, Philipp, Rybakowski, Janusz K., Sathyaputri, Leela, Scippa, Angela M., Simhandl, Christian, Smith, Daniel, Smith, José, Stackhouse, Jr, Paul W., Stein, Dan J., Stilwell, Kellen, Strejilevich, Sergio, Su, Kuan-Pin, Subramaniam, Mythily, Sulaiman, Ahmad Hatim, Suominen, Kirsi, Tanra, Andi J., Tatebayashi, Yoshitaka, Teh, Wen Lin, Tondo, Leonardo, Torrent, Carla, Tuinstra, Daniel, Uchida, Takahito, Vaaler, Arne E., Vieta, Eduard, Viswanath, Biju, Yoldi-Negrete, Maria, Yalcinkaya, Oguz Kaan, Young, Allan H., Zgueb, Yosra, and Whybrow, Peter C.

Published
2023
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35. Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer’s disease related proteins

Author

Oatman, Stephanie R., Reddy, Joseph S., Quicksall, Zachary, Carrasquillo, Minerva M., Wang, Xue, Liu, Chia-Chen, Yamazaki, Yu, Nguyen, Thuy T., Malphrus, Kimberly, Heckman, Michael, Biswas, Kristi, Nho, Kwangsik, Baker, Matthew, Martens, Yuka A., Zhao, Na, Kim, Jun Pyo, Risacher, Shannon L., Rademakers, Rosa, Saykin, Andrew J., DeTure, Michael, Murray, Melissa E., Kanekiyo, Takahisa, Dickson, Dennis W., Bu, Guojun, Allen, Mariet, and Ertekin-Taner, Nilüfer

Published
2023
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39. Coronavirus Disease Update on Epidemiology, Virology, and Prevention.

Author

Banava, Sepideh, Gansky, Stuart A, and Reddy, Michael S

Subjects
Clinical Research, Prevention, Infectious Diseases, Biodefense, Emerging Infectious Diseases, Vaccine Related, Infection, Good Health and Well Being, COVID-19, Humans, Pandemics, SARS-CoV-2
Abstract

In March 2020, the World Health Organization declared COVID-19 as the first coronavirus-initiated pandemic. COVID-19's fast-paced global spread with a broad range of clinical manifestations compelled health regulatory organizations, public health professionals, and researchers to update their information about the disease and provide individual- and community-based guidelines, solutions, and regulations to break the disease cycle, mitigate person-to-person transmission, and reduce cross-contamination in healthcare settings. In this review, the authors provide known facts and updated information about SARS-CoV-2 virology and its new variants, transmission routes, reported clinical symptoms, epidemiology, and infection control and prevention guidelines with a focus on a hierarchy of controls in dental settings.

Published
2021

43. Effect of Magnetisation of Bulk Superconductors on Permanent Magnets for Reversible Braking Applications

Author

Goona, Nithin, Reddy, P. S., and Sashidhar, S.

Subjects
Condensed Matter - Superconductivity
Abstract

Magnetisation of superconductors are often measured under isothermal and uniform magnetic fields. Magnetisation measurements in an unrestricted thermodynamic state and in non uniform magnetic fields naturally emerge from permanent magnets in comparison with size of superconducting bulk are needed for practical applications. A stationary Type II superconductor bulk sample is magnetised (FC and ZFC) at liquid nitrogen temperatures in the presence of a stationary permanent magnet. Magnetic field produced by magnetised superconductor and permanent magnet as a function of distance are measured along a straight line, a supposed path of another moving permanent magnet. A moving magnet is introduced and moved along the same straight line. Force acting on moving magnet as a function of distance are measured due to magnetisation in superconductor and stationary magnet. Both field and force measurements are quasi static. These experimental results combined with simulation results show insight in to the transfer of energy stored in magnetisation to thermal energy and the effect of rate of this energy transfer in AC response of superconductors which are otherwise not possible with isothermal studies. A possible application of reversible braking with bulk superconductors for motors and generators is explored. Future similar measurements with Type I superconductor would provide more insights in to this study., Comment: PASREG 2019

Published
2019

44. Proline-rich domain of human ALIX contains multiple TSG101-UEV interaction sites and forms phosphorylation-mediated reversible amyloids

Author

Elias, Ruben D, Ma, Wen, Ghirlando, Rodolfo, Schwieters, Charles D, Reddy, Vijay S, and Deshmukh, Lalit

Subjects
Biochemistry and Cell Biology, Biological Sciences, Generic health relevance, Amino Acid Motifs, Amyloid, Binding Sites, Calcium-Binding Proteins, Cell Cycle Proteins, DNA-Binding Proteins, Endosomal Sorting Complexes Required for Transport, Humans, Phosphorylation, Proline, Protein Binding, Protein Domains, Transcription Factors, intrinsically disordered protein, posttranslational modifications, amyloids, NMR, signal transduction
Abstract

Proline-rich domains (PRDs) are among the most prevalent signaling modules of eukaryotes but often unexplored by biophysical techniques as their heterologous recombinant expression poses significant difficulties. Using a "divide-and-conquer" approach, we present a detailed investigation of a PRD (166 residues; ∼30% prolines) belonging to a human protein ALIX, a versatile adaptor protein involved in essential cellular processes including ESCRT-mediated membrane remodeling, cell adhesion, and apoptosis. In solution, the N-terminal fragment of ALIX-PRD is dynamically disordered. It contains three tandem sequentially similar proline-rich motifs that compete for a single binding site on its signaling partner, TSG101-UEV, as evidenced by heteronuclear NMR spectroscopy. Global fitting of relaxation dispersion data, measured as a function of TSG101-UEV concentration, allowed precise quantitation of these interactions. In contrast to the soluble N-terminal portion, the C-terminal tyrosine-rich fragment of ALIX-PRD forms amyloid fibrils and viscous gels validated using dye-binding assays with amyloid-specific probes, congo red and thioflavin T (ThT), and visualized by transmission electron microscopy. Remarkably, fibrils dissolve at low temperatures (2 to 6 °C) or upon hyperphosphorylation with Src kinase. Aggregation kinetics monitored by ThT fluorescence shows that charge repulsion dictates phosphorylation-mediated fibril dissolution and that the hydrophobic effect drives fibril formation. These data illuminate the mechanistic interplay between interactions of ALIX-PRD with TSG101-UEV and polymerization of ALIX-PRD and its central role in regulating ALIX function. This study also demonstrates the broad functional repertoires of PRDs and uncovers the impact of posttranslational modifications in the modulation of reversible amyloids.

Published
2020

45. Unravelling the Stability and Capsid Dynamics of the Three Virions of Brome Mosaic Virus Assembled Autonomously In Vivo.

Author

Chakravarty, Antara, Reddy, Vijay S, and Rao, ALN

Subjects
Bromovirus, Virion, Capsid, Capsid Proteins, RNA, Bacterial, RNA, Viral, Peptide Mapping, Virus Replication, Virus Assembly, Genome, Viral, Agrobacterium, MALDI-TOF, RNA virus, capsid dynamics, genome packaging, stability, RNA, Bacterial, Viral, Genome, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Virology
Abstract

Viral capsids are dynamic assemblies that undergo controlled conformational transitions to perform various biological functions. The replication-derived four-molecule RNA progeny of Brome mosaic virus (BMV) is packaged by a single capsid protein (CP) into three types of morphologically indistinguishable icosahedral virions with T=3 quasisymmetry. Type 1 (B1V) and type 2 (B2V) virions package genomic RNA1 and RNA2, respectively, while type 3 (B3+4V) virions copackage genomic RNA3 (B3) and its subgenomic RNA4 (sgB4). In this study, the application of a robust Agrobacterium-mediated transient expression system allowed us to assemble each virion type separately in planta Experimental approaches analyzing the morphology, size, and electrophoretic mobility failed to distinguish between the virion types. Thermal denaturation analysis and protease-based peptide mass mapping experiments were used to analyze stability and the conformational dynamics of the individual virions, respectively. The crystallographic structure of the BMV capsid shows four trypsin cleavage sites (K65, R103, K111, and K165 on the CP subunits) exposed on the exterior of the capsid. Irrespective of the digestion time, while retaining their capsid structural integrity, B1V and B2V released a single peptide encompassing amino acids 2 to 8 of the N-proximal arginine-rich RNA binding motif. In contrast, B3+4V capsids were unstable with trypsin, releasing several peptides in addition to the peptides encompassing four predicted sites exposed on the capsid exterior. These results, demonstrating qualitatively different dynamics for the three types of BMV virions, suggest that the different RNA genes they contain may have different translational timing and efficiency and may even impart different structures to their capsids.IMPORTANCE The majority of viruses contain RNA genomes protected by a shell of capsid proteins. Although crystallographic studies show that viral capsids are static structures, accumulating evidence suggests that, in solution, virions are highly dynamic assemblies. The three genomic RNAs (RNA1, -2, and -3) and a single subgenomic RNA (RNA4) of Brome mosaic virus (BMV), an RNA virus pathogenic to plants, are distributed among three physically homogeneous virions. This study examines the thermal stability by differential scanning fluorimetry (DSF) and capsid dynamics by matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) analyses following trypsin digestion of the three virions assembled separately in vivo using the Agrobacterium-mediated transient expression approach. The results provide compelling evidence that virions packaging genomic RNA1 and -2 are distinct from those copackaging RNA3 and -4 in their stability and dynamics, suggesting that RNA-dependent capsid dynamics play an important biological role in the viral life cycle.

Published
2020

48. Ten years of generative adversarial nets (GANs): a survey of the state-of-the-art

Author

Tanujit Chakraborty, Ujjwal Reddy K S, Shraddha M Naik, Madhurima Panja, and Bayapureddy Manvitha

Subjects
adversarial learning, image generation, deep learning, model evaluation and selection, generative adversarial networks, artificial intelligence., Computer engineering. Computer hardware, TK7885-7895, Electronic computers. Computer science, QA75.5-76.95
Abstract

Generative adversarial networks (GANs) have rapidly emerged as powerful tools for generating realistic and diverse data across various domains, including computer vision and other applied areas, since their inception in 2014. Consisting of a discriminative network and a generative network engaged in a minimax game, GANs have revolutionized the field of generative modeling. In February 2018, GAN secured the leading spot on the ‘Top Ten Global Breakthrough Technologies List’ issued by the Massachusetts Science and Technology Review. Over the years, numerous advancements have been proposed, leading to a rich array of GAN variants, such as conditional GAN, Wasserstein GAN, cycle-consistent GAN, and StyleGAN, among many others. This survey aims to provide a general overview of GANs, summarizing the latent architecture, validation metrics, and application areas of the most widely recognized variants. We also delve into recent theoretical developments, exploring the profound connection between the adversarial principle underlying GAN and Jensen–Shannon divergence while discussing the optimality characteristics of the GAN framework. The efficiency of GAN variants and their model architectures will be evaluated along with training obstacles as well as training solutions. In addition, a detailed discussion will be provided, examining the integration of GANs with newly developed deep learning frameworks such as transformers, physics-informed neural networks, large language models, and diffusion models. Finally, we reveal several issues as well as future research outlines in this field.

Published
2024
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