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1. Safety and pharmacokinetics of subcutaneous administration of broadly neutralizing anti-HIV-1 monoclonal antibodies (bNAbs), given to HIV-1 exposed, uninfected neonates and infants: study protocol for a phase I trial

Author

Goga, Ameena, Ramraj, Trisha, Naidoo, Logashvari, Daniels, Brodie, Matlou, Masefetsane, Chetty, Terusha, Dassaye, Reshmi, Ngandu, Nobubelo K., Galli, Laura, Reddy, Tarylee, Seocharan, Ishen, Ndlangamandla, Qondeni, September, Qholokazi, Ngcobo, Nokwanda, Reddy, Mayuri, Cafun-Naidoo, Tamon, Woeber, Kubashni, Jeenarain, Nitesha, Imamdin, Rabia, Maharajh, Keshnee, Ramjeth, Ashmintha, Bhengu, Thobile, Clarence, Emma, Van de Perre, Philippe, Tylleskär, Thorkild, Nagot, Nicolas, Moles, Jean-Pierre, Moore, Penny L., Mkhize, Nonhlanhla N., Gama, Lucio, Dispinseri, Stefania, Biswas, Priscilla, and Scarlatti, Gabriella

Published
2024
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2. Switch to long-acting cabotegravir and rilpivirine in virologically suppressed adults with HIV in Africa (CARES): week 48 results from a randomised, multicentre, open-label, non-inferiority trial

Author

Mugerwa, Henry, Tamale, William, Yiga, Joshua, Asaasira, Susan Esther, Kinyera, Nigel, Nambi, Christine, Nakiboneka, Dridah Luyirika, Kabatana, Rose, Kiyimba, Winfred, Ategeka, Gilbert, Yawe, Ibrahim, Alinaitwe, Adolf, Zawedde, Aidah, Wasswa, George, Arinda, Allan, Rweyora, Angela, Kangah, Mary Goretti, Cresswell, Fiona, Castelnuovo, Barbara, Kaimal, Arvind, Ogwal, Patience, Muhumuza, Neville, Okwero, Max, Ayebare, Peruth, Nakate, Vivian, Asienzo, Jesca, Mayanja, Hamza, Laker, Eva, Shah, Reena, Riunga, Felix, Onyango, Peter Odhiambo, Wanja, Josephine, Sayed, Shaheen, Gohil, Jaimini, Mungathia, Isaiah, Githuka, Alfred Mburu, Kibwage, Haron, Siika, Abraham Mosigisi, Wambui, Charity Kanyoro, Kirui, Viola Cherotich, Kipyego, Jairus, Sang, Natalie, Mokaya, Martha Mokeira Bisieri, Chepkorir, Consolata, Mboya, Chris Sande, Tonui, Ronald, Njulu, Florence, Kaziga, Hilda, Kosgei, Josphat, Sawe, Fredrick, Omol, Magdaline Adhiambo, Riziki, Faith, Daud, Ibrahim, Kimetto, Leelgo, Okumu, Billy Omalla, Lipuku, Francis, Sokhela, Simiso, Venter, Francois, Moller, Karlien, Nzuza, Nompumelelo, Ramela, Gontse, Tom, Noxolo, Nyamuzihwa, Tsitsi, Macholo, Philadelphia, Macebele, Hlamulani, Akpomiemie, Godspower, Naidoo, Logashvari, Jeenarain, Nitesha, Hurbans, Nivriti, Reddy, Mayuri, Mphisa, Gerald Thsepo, Kityo, Cissy, Paton, Nicholas, Mambule, Ivan Kiggundu, Opiyo, Kimton, Musaazi, Joseph, Otike, Caroline, Kabanyoro, Ritah, Sekajja, Francis, Nantumbwe, Sandra, Sekabira, Harriet, Ocitti, Paul, Ouma, Benson, Nankya, Immaculate, Ainembabazi, Pamela, Lötter, Melissa, Mohamed, Saeeda, Herbst, Madel, Peters, Tarryn, Mehta, Heena, Khan, Shaguftha, Kruger, Marlien, van Rein-van der Horst, Willemijn, Addo Boateng, Fafa, Van Solingen, Rodica, Vandermeulen, Kati, Van Eygen, Veerle, Crauwels, Herta, Luo, Donghan, Votto, Donna, Idahosa, Awhonukeh, Mwendia, Fridah, Klasko-Foster, Lynne, Bondal, Malavika, Eshun-Wilsonova, Ingrid, Mohammed, Perry, Spreen, William, D'Amico, Ronald, Kaleebu, Pontiano, Ojoo, Sylvia, Katana, Milly, Moosa, Yunus, Phiri, Sam, Munderi, Paula, Hill, Andrew, Mambule, Ivan K, Siika, Abraham, Möller, Karlien, Wambui, Charity, and Paton, Nicholas I

Published
2024
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4. Switch to long-acting cabotegravir and rilpivirine in virologically suppressed adults with HIV in Africa (CARES): week 48 results from a randomised, multicentre, open-label, non-inferiority trial

Author

Kityo, Cissy, primary, Mambule, Ivan K, additional, Musaazi, Joseph, additional, Sokhela, Simiso, additional, Mugerwa, Henry, additional, Ategeka, Gilbert, additional, Cresswell, Fiona, additional, Siika, Abraham, additional, Kosgei, Josphat, additional, Shah, Reena, additional, Naidoo, Logashvari, additional, Opiyo, Kimton, additional, Otike, Caroline, additional, Möller, Karlien, additional, Kaimal, Arvind, additional, Wambui, Charity, additional, Van Eygen, Veerle, additional, Mohammed, Perry, additional, Addo Boateng, Fafa, additional, Paton, Nicholas I, additional, Tamale, William, additional, Yiga, Joshua, additional, Asaasira, Susan Esther, additional, Kinyera, Nigel, additional, Nambi, Christine, additional, Nakiboneka, Dridah Luyirika, additional, Kabatana, Rose, additional, Kiyimba, Winfred, additional, Yawe, Ibrahim, additional, Alinaitwe, Adolf, additional, Zawedde, Aidah, additional, Wasswa, George, additional, Arinda, Allan, additional, Rweyora, Angela, additional, Kangah, Mary Goretti, additional, Castelnuovo, Barbara, additional, Ogwal, Patience, additional, Muhumuza, Neville, additional, Okwero, Max, additional, Ayebare, Peruth, additional, Nakate, Vivian, additional, Asienzo, Jesca, additional, Mayanja, Hamza, additional, Laker, Eva, additional, Riunga, Felix, additional, Onyango, Peter Odhiambo, additional, Wanja, Josephine, additional, Sayed, Shaheen, additional, Gohil, Jaimini, additional, Mungathia, Isaiah, additional, Githuka, Alfred Mburu, additional, Kibwage, Haron, additional, Siika, Abraham Mosigisi, additional, Wambui, Charity Kanyoro, additional, Kirui, Viola Cherotich, additional, Kipyego, Jairus, additional, Sang, Natalie, additional, Mokaya, Martha Mokeira Bisieri, additional, Chepkorir, Consolata, additional, Mboya, Chris Sande, additional, Tonui, Ronald, additional, Njulu, Florence, additional, Kaziga, Hilda, additional, Sawe, Fredrick, additional, Omol, Magdaline Adhiambo, additional, Riziki, Faith, additional, Daud, Ibrahim, additional, Kimetto, Leelgo, additional, Okumu, Billy Omalla, additional, Lipuku, Francis, additional, Venter, Francois, additional, Moller, Karlien, additional, Nzuza, Nompumelelo, additional, Ramela, Gontse, additional, Tom, Noxolo, additional, Nyamuzihwa, Tsitsi, additional, Macholo, Philadelphia, additional, Macebele, Hlamulani, additional, Akpomiemie, Godspower, additional, Jeenarain, Nitesha, additional, Hurbans, Nivriti, additional, Reddy, Mayuri, additional, Mphisa, Gerald Thsepo, additional, Kityo, Cissy, additional, Paton, Nicholas, additional, Mambule, Ivan Kiggundu, additional, Kabanyoro, Ritah, additional, Sekajja, Francis, additional, Nantumbwe, Sandra, additional, Sekabira, Harriet, additional, Ocitti, Paul, additional, Ouma, Benson, additional, Nankya, Immaculate, additional, Ainembabazi, Pamela, additional, Lötter, Melissa, additional, Mohamed, Saeeda, additional, Herbst, Madel, additional, Peters, Tarryn, additional, Mehta, Heena, additional, Khan, Shaguftha, additional, Kruger, Marlien, additional, van Rein-van der Horst, Willemijn, additional, Van Solingen, Rodica, additional, Vandermeulen, Kati, additional, Crauwels, Herta, additional, Luo, Donghan, additional, Votto, Donna, additional, Idahosa, Awhonukeh, additional, Mwendia, Fridah, additional, Klasko-Foster, Lynne, additional, Bondal, Malavika, additional, Eshun-Wilsonova, Ingrid, additional, Spreen, William, additional, D'Amico, Ronald, additional, Kaleebu, Pontiano, additional, Ojoo, Sylvia, additional, Katana, Milly, additional, Moosa, Yunus, additional, Phiri, Sam, additional, Munderi, Paula, additional, and Hill, Andrew, additional

Published
2024
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5. Yield and Utility of Routine Epilepsy Panel Genetic Testing Among Young Patients With Seizures.

Author

Grew, Emily, Reddy, Mayuri, Reichner, Hayley, Kim, Jinsoo, Salam, Misbah, and Hashim, Anjum

Subjects
*GENETIC testing, *RECESSIVE genes, *EPILEPSY, *SEIZURES (Medicine), *CHILD patients, *MAGNETIC resonance imaging
Abstract

Objective: We examined the yield of routine epilepsy panel genetic testing in pediatric patients. Methods: We retrospectively reviewed epilepsy genetic panel results routinely performed in the hospital or clinic on patients <8 years old from July 2021 to July 2023. We evaluated demographics, family history, seizure type, severity, and frequency, development, tone and movement abnormalities, dysmorphism, and electroencephalography (EEG) or magnetic resonance imaging (MRI) results as predictors of results. Results: 65 patients were included with mean age 4.5 years. Sixty percent of patients were male; 11 patients had pathogenic variants (16.9%), 7 were carriers for autosomal recessive conditions (10.8%), 36 had variants of uncertain significance (55.4%), and 11 tested negative (16.9%). Pathogenic variants and variants of uncertain significance were unassociated with demographics, clinical features, imaging, or family history. Conclusion: Variants identified have potential implications for treatment (SCN1), comorbidity screening (TSC1), reproduction (ATAD1, PSAT1, and CLN8), and prognostication (FOXG1). Patients not routinely screened for a genetic cause of epilepsy by our standard practices had clinically relevant results. [ABSTRACT FROM AUTHOR]

Published
2024
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7. A Cross Sectional Study on Behavioural Pattern and Its Association with Various Factors among Children Living in Orphanages in Chitradurga, Karnataka, India.

Author

Reddy, Mayuri Reddy and Salam, Sameeya Furmeen

Subjects
ORPHANS, CHILD mental health services, ORPHANAGES, MENTAL illness, CROSS-sectional method
Abstract

Background: Orphans are the most underprivileged groups in each society. Children who live in orphanage have significantly higher rates of growth and development problems, serious mental health problems, and difficulties accessing health services. Therefore, there is a need to address the needs of this vulnerable group. This study was conducted with the objective to assess the behavioral pattern of children and its association with various factors in the orphanage. Methods: A Cross Sectional Study was conducted among orphanage children for a period of one year and a total of 297 children between the ages of 6-16 years were included in the study.Their behaviour pattern was assessed using the Strength and Difficulties Questionnaire (SDQ) scale devised by Goodman which includes emotional symptoms, conduct problems, hyperactivity, peer problems and pro social behavior. Data was analyzed using the SPSS version 20. Conclusion: The study revealed that among the various behavioral problems, Peer problems (68.4%) were most frequently reported, followed by Conduct problems (33.7%). The results also shown that the association between child’s age and emotional problems was statistically significant at F value (1.819), p value (0.05) as the age advances the child has more emotional problems. [ABSTRACT FROM AUTHOR]

Published
2023
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