Search

Your search keyword '"Reddy, Elluri Seetharami"' showing total 20 results
Start Over Author "Reddy, Elluri Seetharami"
20 results on '"Reddy, Elluri Seetharami"'

1. Severe disease during both primary and secondary dengue virus infections in pediatric populations

Author

Aggarwal, Charu, Ahmed, Hasan, Sharma, Pragati, Reddy, Elluri Seetharami, Nayak, Kaustuv, Singla, Mohit, Maheshwari, Deepti, Chawla, Yadya M., Panda, Harekrushna, Rai, Ramesh Chandra, Gunisetty, Sivaram, Priyamvada, Lalita, Bhaumik, Siddhartha Kumar, Ahamed, Syed Fazil, Vivek, Rosario, Bhatnagar, Priya, Singh, Prabhat, Kaur, Manpreet, Dixit, Kritika, Kumar, Sanjeev, Gottimukkala, Kamal, Saini, Keshav, Bajpai, Prashant, Sreekanth, Gopinathan Pillai, Mammen, Shobha, Rajan, Anand, Verghese, Valsan Philip, Abraham, Asha Mary, Shah, Paresh, Alagarasu, Kalichamy, Yu, Tianwei, Davis, Carl W., Wrammert, Jens, Ansari, Aftab, Antia, Rustom, Kabra, Sushil Kumar, Medigeshi, Guruprasad R., Ahmed, Rafi, Lodha, Rakesh, Shet, Anita, Chandele, Anmol, and Murali-Krishna, Kaja

Published
2024
Full Text
View/download PDF

2. Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response

Author

Patel, Anamika, Kumar, Sanjeev, Lai, Lilin, Chakravarthy, Chennareddy, Valanparambil, Rajesh, Reddy, Elluri Seetharami, Gottimukkala, Kamalvishnu, Bajpai, Prashant, Raju, Dinesh Ravindra, Edara, Venkata Viswanadh, Davis-Gardner, Meredith E., Linderman, Susanne, Dixit, Kritika, Sharma, Pragati, Mantus, Grace, Cheedarla, Narayanaiah, Verkerke, Hans P., Frank, Filipp, Neish, Andrew S., Roback, John D., Davis, Carl W., Wrammert, Jens, Ahmed, Rafi, Suthar, Mehul S., Sharma, Amit, Murali-Krishna, Kaja, Chandele, Anmol, and Ortlund, Eric A.

Published
2023
Full Text
View/download PDF

3. Regional Variation of the CD4 and CD8 T Cell Epitopes Conserved in Circulating Dengue Viruses and Shared with Potential Vaccine Candidates.

Author

Chawla, Yadya M., Bajpai, Prashant, Saini, Keshav, Reddy, Elluri Seetharami, Patel, Ashok Kumar, Murali-Krishna, Kaja, and Chandele, Anmol

Subjects
DENGUE viruses, T cells, EPITOPES, CD8 antigen, CD4 antigen, VACCINE trials, FENITROTHION
Abstract

As dengue expands globally and many vaccines are under trials, there is a growing recognition of the need for assessing T cell immunity in addition to assessing the functions of neutralizing antibodies during these endeavors. While several dengue-specific experimentally validated T cell epitopes are known, less is understood about which of these epitopes are conserved among circulating dengue viruses and also shared by potential vaccine candidates. As India emerges as the epicenter of the dengue disease burden and vaccine trials commence in this region, we have here aligned known dengue specific T cell epitopes, reported from other parts of the world with published polyprotein sequences of 107 dengue virus isolates available from India. Of the 1305 CD4 and 584 CD8 epitopes, we found that 24% and 41%, respectively, were conserved universally, whereas 27% and 13% were absent in any viral isolates. With these data, we catalogued epitopes conserved in circulating dengue viruses from India and matched them with each of the six vaccine candidates under consideration (TV003, TDEN, DPIV, CYD-TDV, DENVax and TVDV). Similar analyses with viruses from Thailand, Brazil and Mexico revealed regional overlaps and variations in these patterns. Thus, our study provides detailed and nuanced insights into regional variation that should be considered for itemization of T cell responses during dengue natural infection and vaccine design, testing and evaluation. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

4. Functional and transcriptional heterogeneity within the massively expanding HLADR + CD38 + CD8 T cell population in acute febrile dengue patients

Author

Singh, Prabhat, primary, Bajpai, Prashant, additional, Maheshwari, Deepti, additional, Chawla, Yadya M., additional, Saini, Keshav, additional, Reddy, Elluri Seetharami, additional, Gottimukkala, Kamalvishnu, additional, Nayak, Kaustuv, additional, Gunisetty, Sivaram, additional, Aggarwal, Charu, additional, Jain, Shweta, additional, Verma, Chaitanya, additional, Singla, Paras, additional, Soneja, Manish, additional, Wig, Naveet, additional, Murali-Krishna, Kaja, additional, and Chandele, Anmol, additional

Published
2023
Full Text
View/download PDF

5. Analysis of dengue specific memory B cells, neutralizing antibodies and binding antibodies in healthy adults from India

Author

Gunisetty, Sivaram, Nayak, Kaustuv, Chandra Rai, Ramesh, Chawla, Yadya, Reddy, Elluri Seetharami, Aggarwal, Charu, Maheshwari, Deepti, Panda, Harekrushna, Ansari, Nasim Akhtar, Singh, Prabhat, Kaur, Manpreet, Dixit, Kritika, Sharma, Pragati, Bhatnagar, Priya, Priyamvada, Lalita, Bhaumik, Siddhartha Kumar, Ahamed, Syed Fazil, Vivek, Rosario, Ray, Pratima, Shet, Anita, Coshic, Poonam, Lodha, Rakesh, Kabra, Sushil Kumar, Afroze, Dil, Yousuf, Adfar, Ahmed, Rafi, Murali-Krishna, Kaja, and Chandele, Anmol

Published
2019
Full Text
View/download PDF

6. Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response

Author

Patel, Anamika, primary, Kumar, Sanjeev, additional, Lai, Lilin, additional, Chakravarthy, Chennareddy, additional, Valanparambil, Rajesh, additional, Reddy, Elluri Seetharami, additional, Gottimukkala, Kamalvishnu, additional, Bajpai, Prashant, additional, Raju, Dinesh Ravindra, additional, Edara, Venkata Viswanadh, additional, Davis-Gardner, Meredith E., additional, Linderman, Susanne, additional, Dixit, Kritika, additional, Sharma, Pragati, additional, Mantus, Grace, additional, Cheedarla, Narayanaiah, additional, Verkerke, Hans P., additional, Frank, Filipp, additional, Neish, Andrew S., additional, Roback, John D., additional, Davis, Carl W., additional, Wrammert, Jens, additional, Ahmed, Rafi, additional, Suthar, Mehul S., additional, Sharma, Amit, additional, Murali-Krishna, Kaja, additional, Chandele, Anmol, additional, and Ortlund, Eric A., additional

Published
2022
Full Text
View/download PDF

7. Structural insights for neutralization of Omicron variants BA.1, BA.2, BA.4, and BA.5 by a broadly neutralizing SARS-CoV-2 antibody

Author

Kumar, Sanjeev, primary, Patel, Anamika, additional, Lai, Lilin, additional, Chakravarthy, Chennareddy, additional, Valanparambil, Rajesh, additional, Reddy, Elluri Seetharami, additional, Gottimukkala, Kamalvishnu, additional, Davis-Gardner, Meredith E., additional, Edara, Venkata Viswanadh, additional, Linderman, Susanne, additional, Nayak, Kaustuv, additional, Dixit, Kritika, additional, Sharma, Pragati, additional, Bajpai, Prashant, additional, Singh, Vanshika, additional, Frank, Filipp, additional, Cheedarla, Narayanaiah, additional, Verkerke, Hans P., additional, Neish, Andrew S., additional, Roback, John D., additional, Mantus, Grace, additional, Goel, Pawan Kumar, additional, Rahi, Manju, additional, Davis, Carl W., additional, Wrammert, Jens, additional, Godbole, Sucheta, additional, Henry, Amy R., additional, Douek, Daniel C., additional, Suthar, Mehul S., additional, Ahmed, Rafi, additional, Ortlund, Eric, additional, Sharma, Amit, additional, Murali-Krishna, Kaja, additional, and Chandele, Anmol, additional

Published
2022
Full Text
View/download PDF

8. Structural insights for neutralization of BA.1 and BA.2 Omicron variants by a broadly neutralizing SARS-CoV-2 antibody

Author

Kumar, Sanjeev, primary, Patel, Anamika, additional, Lai, Lilin, additional, Chakravarthy, Chennareddy, additional, Valanparambil, Rajesh, additional, Davis-Gardner, Meredith E., additional, Edara, Venkata Viswanadh, additional, Linderman, Susanne, additional, Reddy, Elluri Seetharami, additional, Gottimukkala, Kamalvishnu, additional, Nayak, Kaustuv, additional, Bajpai, Prashant, additional, Singh, Vanshika, additional, Frank, Filipp, additional, Cheedarla, Narayanaiah, additional, Verkerke, Hans P., additional, Neish, Andrew S., additional, Roback, John D., additional, Mantus, Grace, additional, Goel, Pawan Kumar, additional, Rahi, Manju, additional, Davis, Carl W., additional, Wrammert, Jens, additional, Suthar, Mehul S., additional, Ahmed, Rafi, additional, Ortlund, Eric, additional, Sharma, Amit, additional, Murali-Krishna, Kaja, additional, and Chandele, Anmol, additional

Published
2022
Full Text
View/download PDF

10. Immunophenotyping and Transcriptional Profiling of Human Plasmablasts in Dengue

Author

Aggarwal, Charu, primary, Saini, Keshav, additional, Reddy, Elluri Seetharami, additional, Singla, Mohit, additional, Nayak, Kaustuv, additional, Chawla, Yadya M., additional, Maheshwari, Deepti, additional, Singh, Prabhat, additional, Sharma, Pragati, additional, Bhatnagar, Priya, additional, Kumar, Sanjeev, additional, Gottimukkala, Kamalvishnu, additional, Panda, Harekrushna, additional, Gunisetty, Sivaram, additional, Davis, Carl W., additional, Kissick, Haydn Thomas, additional, Kabra, Sushil Kumar, additional, Lodha, Rakesh, additional, Medigeshi, Guruprasad R., additional, Ahmed, Rafi, additional, Murali-Krishna, Kaja, additional, and Chandele, Anmol, additional

Published
2021
Full Text
View/download PDF

11. Characterization of neutralizing versus binding antibodies and memory B cells in COVID-19 recovered individuals from India

Author

Nayak, Kaustuv, primary, Gottimukkala, Kamalvishnu, additional, Kumar, Sanjeev, additional, Reddy, Elluri Seetharami, additional, Edara, Venkata Viswanadh, additional, Kauffman, Robert, additional, Floyd, Katharine, additional, Mantus, Grace, additional, Savargaonkar, Deepali, additional, Goel, Pawan Kumar, additional, Arora, Satyam, additional, Rahi, Manju, additional, Davis, Carl W., additional, Linderman, Susanne, additional, Wrammert, Jens, additional, Suthar, Mehul S., additional, Ahmed, Rafi, additional, Sharma, Amit, additional, Murali-Krishna, Kaja, additional, and Chandele, Anmol, additional

Published
2021
Full Text
View/download PDF

12. Characterization of neutralizing versus binding antibodies and memory B cells in COVID-19 recovered individuals from India

Author

Nayak, Kaustuv, primary, Gottimukkala, Kamalvishnu, additional, Kumar, Sanjeev, additional, Reddy, Elluri Seetharami, additional, Edara, Venkata Viswanadh, additional, Kauffman, Robert, additional, Floyd, Katharine, additional, Mantus, Grace, additional, Savargaonkar, Deepali, additional, Goel, Pawan Kumar, additional, Arora, Satyam, additional, Rahi, Manju, additional, Davis, Carl W, additional, Linderman, Susanne, additional, Wrammert, Jens, additional, Suthar, Mehul S, additional, Ahmed, Rafi, additional, Sharma, Amit, additional, Murali-Krishna, Kaja, additional, and Chandele, Anmol, additional

Published
2020
Full Text
View/download PDF

13. Human immunity to chikungunya infection

Author

NAYAK, KAUSTUV, primary, Jain, Vineet, additional, Kaur, Manpreet, additional, Khan, Naushad, additional, Rai, Ramesh Chandra, additional, Dixit, Kritika, additional, Sagar, Rohit, additional, Gupta, Shipra, additional, Islamuddin, Mohammad, additional, Verma, Anil, additional, Maheshwari, Deepti, additional, Aggarwal, Charu, additional, Chawla, Yadya, additional, Reddy, Elluri Seetharami, additional, Panda, Harekrushna, additional, Sharma, Pragati, additional, Bhatnagar, Priya, additional, Singh, Prabhat, additional, Ratageri, Vinod H, additional, Chandele, Anmol, additional, Ray, Pratima, additional, and Muralikrishna, Kaja, additional

Published
2020
Full Text
View/download PDF

14. Antibody response patterns in chikungunya febrile phase predict protection versus progression to chronic arthritis

Author

Nayak, Kaustuv, primary, Jain, Vineet, additional, Kaur, Manpreet, additional, Khan, Naushad, additional, Gottimukkala, Kamalvishnu, additional, Aggarwal, Charu, additional, Sagar, Rohit, additional, Gupta, Shipra, additional, Rai, Ramesh Chandra, additional, Dixit, Kritika, additional, Islamuddin, Mohammad, additional, Khan, Wajihul Hasan, additional, Verma, Anil, additional, Maheshwari, Deepti, additional, Chawla, Yadya M., additional, Reddy, Elluri Seetharami, additional, Panda, Harekrushna, additional, Sharma, Pragati, additional, Bhatnagar, Priya, additional, Singh, Prabhat, additional, Raghavendhar B, Siva, additional, Patel, Ashok Kumar, additional, Ratageri, Vinod H., additional, Chandele, Anmol, additional, Ray, Pratima, additional, and Murali-Krishna, Kaja, additional

Published
2020
Full Text
View/download PDF

15. An HIV-1 Broadly Neutralizing Antibody from a Clade C-Infected Pediatric Elite Neutralizer Potently Neutralizes the Contemporaneous and Autologous Evolving Viruses

Author

Kumar, Sanjeev, primary, Panda, Harekrushna, additional, Makhdoomi, Muzamil Ashraf, additional, Mishra, Nitesh, additional, Safdari, Haaris Ahsan, additional, Chawla, Himanshi, additional, Aggarwal, Heena, additional, Reddy, Elluri Seetharami, additional, Lodha, Rakesh, additional, Kumar Kabra, Sushil, additional, Chandele, Anmol, additional, Dutta, Somnath, additional, and Luthra, Kalpana, additional

Published
2019
Full Text
View/download PDF

16. An HIV-1 broadly neutralizing antibody from a clade C infected pediatric elite neutralizer potently neutralizes the contemporaneous and autologous evolving viruses

Author

Kumar, Sanjeev, primary, Panda, Harekrushna, additional, Makhdoomi, Muzamil Ashraf, additional, Mishra, Nitesh, additional, Safdari, Haaris Ahsan, additional, Aggarwal, Heena, additional, Reddy, Elluri Seetharami, additional, Lodha, Rakesh, additional, Kabra, Sushil Kumar, additional, Chandele, Anmol, additional, Dutta, Somnath, additional, and Luthra, Kalpana, additional

Published
2018
Full Text
View/download PDF

17. Characterization of Human CD8 T Cell Responses in Dengue Virus-Infected Patients from India

Author

Chandele, Anmol, primary, Sewatanon, Jaturong, additional, Gunisetty, Sivaram, additional, Singla, Mohit, additional, Onlamoon, Nattawat, additional, Akondy, Rama S., additional, Kissick, Haydn Thomas, additional, Nayak, Kaustuv, additional, Reddy, Elluri Seetharami, additional, Kalam, Haroon, additional, Kumar, Dhiraj, additional, Verma, Anil, additional, Panda, HareKrushna, additional, Wang, Siyu, additional, Angkasekwinai, Nasikarn, additional, Pattanapanyasat, Kovit, additional, Chokephaibulkit, Kulkanya, additional, Medigeshi, Guruprasad R., additional, Lodha, Rakesh, additional, Kabra, Sushil, additional, Ahmed, Rafi, additional, and Murali-Krishna, Kaja, additional

Published
2016
Full Text
View/download PDF

18. Functional and transcriptional heterogeneity within the massively expanding HLADR+CD38+ CD8 T cell population in acute febrile dengue patients.

Author

Singh, Prabhat, Bajpai, Prashant, Maheshwari, Deepti, Chawla, Yadya M., Saini, Keshav, Reddy, Elluri Seetharami, Gottimukkala, Kamalvishnu, Nayak, Kaustuv, Gunisetty, Sivaram, Aggarwal, Charu, Jain, Shweta, Verma, Chaitanya, Singla, Paras, Soneja, Manish, Wig, Naveet, Murali-Krishna, Kaja, and Chandele, Anmol

Subjects
*T cells, *CELL populations, *CD8 antigen, *T cell receptors, *DENGUE, *DENGUE viruses, *T-cell exhaustion, *FENITROTHION
Abstract

CD8 T cells are important tools for protection against intracellularly replicating pathogens such as viruses. Previous studies showed that a discrete population of HLADR and CD38-expressing CD8 T cells expands massively during the acute febrile phase of human dengue virus infection--but very few of these cells secrete IFNγ upon in vitro stimulation with dengue peptides. To gain a better understanding of what other cytokines/chemokines do these massively expanding HLADR+CD38+ CD8 T cells express, we performed RNA seq of sorted HLADR+CD38+ CD8 T cell subsets after peptide stimulation. A majority of these peptide-stimulated HLADR+CD38+ CD8 T cells were CD69- IFNγ-, nearly a third were CD69+ IFNγ-, whereas very few (<10%) were CD69+ IFNγ+. The CD69- IFNγ- subset was enriched for the expression of key genes implicated in the negative regulation of T cell receptor (TCR) signaling and T-cell exhaustion, attraction of B cells and other lymphocytes, and cytokines related to Tc17/T-reg lineages or those that are implicated in immunosuppression/immunomodulatory and anti-inflammatory activities and angiogenesis. The CD69+ IFNγ- subset showed enriched transcription of key genes implicated in cytotoxic effector functions as well as costimulatory and signaling adaptors implicated in fine balancing of T cell receptor signaling. The CD69+ IFNγ+ subset largely shared the transcriptional profile with the CD69+ IFNγsubset--but with relatively more pronounced expression along with additional genes such as chemokines XCL1/XCL2. Our findings showing distinct functional subsets among these massively expanding CD8 T cells in dengue CD8 T cells warrant further studies to carefully examine the precise role of these T cell subsets in protection against dengue. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

19. Plant dehydroascorbate reductase moonlights as membrane integrated ion channel.

Author

Das, Bhaba Krishna, Khan, Wajahat Ali, Sreekumar, Sreeshma Nellootil, Ponraj, Kannapiran, Achary, V. Mohan Murali, Reddy, Elluri Seetharami, Balasubramaniam, D., Chandele, Anmol, Reddy, Malireddy K., and Arockiasamy, Arulandu

Subjects
*CHLORIDE channels, *ION channels, *PLANT plasma membranes, *MONONUCLEAR leukocytes, *BILAYER lipid membranes, *CELL membranes, *PEARL millet
Abstract

Plant dehydroascorbate reductases (DHARs) are only known as soluble antioxidant enzymes of the ascorbate-glutathione pathway. They recycle ascorbate from dehydroascorbate, thereby protecting plants from oxidative stress and the resulting cellular damage. DHARs share structural GST fold with human chloride intracellular channels (HsCLICs) which are dimorphic proteins that exists in soluble enzymatic and membrane integrated ion channel forms. While the soluble form of DHAR has been extensively studied, the existence of a membrane integrated form remains unknown. We demonstrate for the first time using biochemistry, immunofluorescence confocal microscopy, and bilayer electrophysiology that Pennisetum glaucum DHAR (PgDHAR) is dimorphic and is localized to the plant plasma membrane. In addition, membrane translocation increases under induced oxidative stress. Similarly, HsCLIC1 translocates more into peripheral blood mononuclear cells (PBMCs) plasma membrane under induced oxidative stress conditions. Moreover, purified soluble PgDHAR spontaneously inserts and conducts ions in reconstituted lipid bilayers, and the addition of detergent facilitates insertion. In addition to the well-known soluble enzymatic form, our data provides conclusive evidence that plant DHAR also exists in a novel membrane-integrated form. Thus, the structure of DHAR ion channel form will help gain deeper insights into its function across various life forms. [Display omitted] • Plant dehydroascorbate reductase (DHAR) is dimorphic and bifunctional. • Pennisetum glaucum DHAR (PgDHAR) moonlights as a membrane integrated channel. • PgDHAR and HsCLIC1 membrane translocation increases under induced oxidative stress. • Soluble PgDHAR spontaneously inserts and conducts ions in planar lipid bilayers. • Detergent facilitates PgDHAR channel insertion. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

20. Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response.

Author

Patel A, Kumar S, Lai L, Chakravarthy C, Valanparambil R, Reddy ES, Gottimukkala K, Bajpai P, Raju DR, Edara VV, Davis-Gardner ME, Linderman S, Dixit K, Sharma P, Mantus G, Cheedarla N, Verkerke HP, Frank F, Neish AS, Roback JD, Davis CW, Wrammert J, Ahmed R, Suthar MS, Sharma A, Murali-Krishna K, Chandele A, and Ortlund EA

Abstract

A detailed understanding of the molecular features of the neutralizing epitopes developed by viral escape mutants is important for predicting and developing vaccines or therapeutic antibodies against continuously emerging SARS-CoV-2 variants. Here, we report three human monoclonal antibodies (mAbs) generated from COVID-19 recovered individuals during first wave of pandemic in India. These mAbs had publicly shared near germline gene usage and potently neutralized Alpha and Delta, but poorly neutralized Beta and completely failed to neutralize Omicron BA.1 SARS-CoV-2 variants. Structural analysis of these three mAbs in complex with trimeric spike protein showed that all three mAbs are involved in bivalent spike binding with two mAbs targeting class-1 and one targeting class-4 Receptor Binding Domain (RBD) epitope. Comparison of immunogenetic makeup, structure, and function of these three mAbs with our recently reported class-3 RBD binding mAb that potently neutralized all SARS-CoV-2 variants revealed precise antibody footprint, specific molecular interactions associated with the most potent multi-variant binding / neutralization efficacy. This knowledge has timely significance for understanding how a combination of certain mutations affect the binding or neutralization of an antibody and thus have implications for predicting structural features of emerging SARS-CoV-2 escape variants and to develop vaccines or therapeutic antibodies against these.

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results