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4. Burden of Uncontrolled Severe Asthma With and Without Elevated Type-2 Inflammatory Biomarkers

Author

del Olmo, Ricardo, Anderson, Gary, Reddel, Helen, Rabahi, Marcelo, McIvor, Andrew, Sadatsafavi, Mohsen, Weinreich, Ulla, Burgel, Pierre-Régis, Devouassoux, Gilles, Papi, Alberto, Inoue, Hiromasa, Rendon, Adrián, van den Berge, Maarten, Beasley, Richard, García-Navarro, Alvar Agusti, Faner, Rosa, Rivera, José Olaguibel, Janson, Christer, Bilińska-Izydorczyk, Magdalena, Fagerås, Malin, Fihn-Wikander, Titti, Franzén, Stefan, Keen, Christina, Ostridge, Kristoffer, Chalmers, James, Harrison, Timothy, Pavord, Ian, Price, David, Azim, Adnan, Belton, Laura, Blé, Francois-Xavier, Erhard, Clement, Gairy, Kerry, Hughes, Rod, Lassi, Glenda, Müllerová, Hana, Rapsomaniki, Eleni, Scott, Ian Christopher, Chipps, Bradley, Christenson, Stephanie, Make, Barry, Tomaszewski, Erin, Benhabib, Gabriel, Ruiz, Xavier Bocca, Lisanti, Raul Eduardo, Marino, Gustavo, Mattarucco, Walter, Nogueira, Juan, Parody, Maria, Pascale, Pablo, Rodriguez, Pablo, Silva, Damian, Svetliza, Graciela, Victorio, Carlos F., Rolon, Roxana Willigs, Yañez, Anahi, Baines, Stuart, Bowler, Simon, Bremner, Peter, Bull, Sheetal, Carroll, Patrick, Chaalan, Mariam, Farah, Claude, Hammerschlag, Gary, Hancock, Kerry, Harrington, Zinta, Katsoulotos, Gregory, Kim, Joshua, Langton, David, Lee, Donald, Peters, Matthew, Prassad, Lakshman, Sajkov, Dimitar, Santiago, Francis, Simpson, Frederick Graham, Tai, Sze, Thomas, Paul, Wark, Peter, Delfini Cançado, José Eduardo, Cunha, Thúlio, Lima, Marina, Cardoso, Alexandre Pinto, FitzGerald, J. Mark, Anees, Syed, Bertley, John, Bell, Alan, Cheema, Amarjit, Chouinard, Guy, Csanadi, Michael, Dhar, Anil, Dhillon, Ripple, Kanawaty, David, Kelly, Allan, Killorn, William, Landry, Daniel, Luton, Robert, Mandhane, Piushkumar, Pek, Bonavuth, Petrella, Robert, Stollery, Daniel, Wang, Chen, Chen, Meihua, Chen, Yan, Gu, Wei, Christopher Hui, Kim Ming, Li, Manxiang, Li, Shiyue, Lijun, Ma, Qin, Guangyue, Song, Weidong, Tan, Wei, Tang, Yijun, Wang, Tan, Wen, Fuqiang, Wu, Feng, Xiang, PingChao, Xiao, Zuke, Xiong, Shengdao, Yang, Jinghua, Yang, Jingping, Zhang, Caiqing, Zhang, Min, Zhang, Ping, Zhang, Wei, Zheng, Xiaohe, Zhu, Dan, Bueno, Carlos Matiz, Grimaldos, Fabio Bolivar, Arboleda, Alejandra Cañas, Molina de Salazar, Dora, Bendstrup, Elisabeth, Hilberg, Ole, Kjellerup, Carsten, Raherison, Chantal, Bonniaud, Philippe, Brun, Olivier, Chouaid, Christos, Couturaud, Francis, de Blic, Jacques, Debieuvre, Didier, Delsart, Dominique, Demaegdt, Axelle, Demoly, Pascal, Deschildre, Antoine, Egron, Carole, Falchero, Lionel, Goupil, François, Kessler, Romain, Le Roux, Pascal, Mabire, Pascal, Mahay, Guillaume, Martinez, Stéphanie, Melloni, Boris, Moreau, Laurent, Riviere, Emilie, Roux-Claudé, Pauline, Soulier, Michel, Vignal, Guillaume, Yaici, Azzedine, Bals, Robert, Aries, Sven Philip, Beck, Ekkehard, Deimling, Andreas, Feimer, Jan, Grimm-Sachs, Vera, Groth, Gesine, Herth, Felix, Hoheisel, Gerhard, Kanniess, Frank, Lienert, Thomas, Mronga, Silke, Reinhardt, Jörg, Schlenska, Christian, Stolpe, Christoph, Teber, Ishak, Timmermann, Hartmut, Ulrich, Thomas, Velling, Peter, Wehgartner-Winkler, Sabina, Welling, Juergen, Winkelmann, Ernst-Joachim, Barbetta, Carlo, Braido, Fulvio, Cardaci, Vittorio, Clini, Enrico Maria, Costantino, Maria Teresa, Cuttitta, Giuseppina, di Gioacchino, Mario, Fois, Alessandro, Foschino-Barbaro, Maria Pia, Gammeri, Enrico, Inchingolo, Riccardo, Lavorini, Federico, Molino, Antonio, Nucera, Eleonora, Patella, Vincenzo, Pesci, Alberto, Ricciardolo, Fabio, Rogliani, Paola, Sarzani, Riccardo, Vancheri, Carlo, Vincenti, Rigoletta, Endo, Takeo, Fujita, Masaki, Hara, Yu, Horiguchi, Takahiko, Hosoi, Keita, Ide, Yumiko, Inomata, Minehiko, Inoue, Koji, Inoue, Sumito, Kato, Motokazu, Kawasaki, Masayuki, Kawayama, Tomotaka, Kita, Toshiyuki, Kobayashi, Kanako, Koto, Hiroshi, Nishi, Koichi, Saito, Junpei, Shimizu, Yasuo, Shirai, Toshihiro, Sugihara, Naruhiko, Takahashi, Ken-ichi, Tashimo, Hiroyuki, Tomii, Keisuke, Yamada, Takashi, Yanai, Masaru, Rendon, Adrian, Javier, Ruth Cerino, Peregrina, Alfredo Domínguez, Corzo, Marco Fernández, Gonzalez, Efraín Montano, Ramírez-Venegas, Alejandra, Boersma, Willem, Djamin, R.S., Eijsvogel, Michiel, Franssen, Frits, Goosens, Martijn, Graat-Verboom, Lidwien, Veen, Johannes in 't, Janssen, Rob, Kuppens, Kim, van de Ven, Mario, Bakke, Per, Brunstad, Ole Petter, Einvik, Gunnar, Høines, Kristian Jong, Khusrawi, Alamdar, Oien, Torbjorn, Yoon, Ho Joo, Chang, Yoon-Seok, Cho, Young Joo, Hwang, Yong Il, Kim, Woo Jin, Koh, Young-Il, Lee, Byung-Jae, Lee, Kwan-Ho, Lee, Sang-Pyo, Lee, Yong Chul, Lim, Seong Yong, Min, Kyung Hun, Oh, Yeon-Mok, Park, Choon-Sik, Park, Hae-Sim, Park, Heung-Woo, Rhee, Chin Kook, Yoon, Hyoung-Kyu, Andújar, Rubén, Anoro, Laura, García, María Buendía, Mozo, Paloma Campo, Campos, Sergio, Maldonado, Francisco Casas, Martínez, Manuel Castilla, Serrano, Carolina Cisneros, Casanova, Lorena Comeche, Corbacho, Dolores, Del Campo Matías, Felix, Echave-Sustaeta, Jose, Corral, Gloria Francisco, Setién, Pedro Gamboa, Clemente, Marta García, Núñez, Ignacio García, Robaina, Jose García, Salmones, Mercedes García, Marín Trigo, Jose Maria, Fernandez, Marta Nuñez, Palomo, Sara Nuñez, Pérez de Llano, Luis, Bastida, Ana Pueyo, Rañó, Ana, González-Moro, José Rodríguez, Reig, Albert Roger, Garrido, José Velasco, Curiac, Dan, Lif-Tiberg, Cornelia, Luts, Anders, Råhlen, Lennart, Rustscheff, Stefan, Adams, Frances, Bradman, Drew, Broughton, Emma, Cosgrove, John, Flood-Page, Patrick, Fuller, Elizabeth, Hartley, David, Hattotuwa, Keith, Jones, Gareth, Lewis, Keir, McGarvey, Lorcan, Morice, Alyn, Pandya, Preeti, Patel, Manish, Roy, Kay, Sathyamurthy, Ramamurthy, Thiagarajan, Swaminathan, Turner, Alice, Vestbo, Jorgen, Wedzicha, Wisia, Wilkinson, Tom, Wilson, Pete, Al-Asadi, Lo’Ay, Anholm, James, Averill, Francis, Bansal, Sandeep, Baptist, Alan, Campbell, Colin, Campos, Michael A., Crook, Gretchen, DeLeon, Samuel, Eid, Alain, Epstein, Ellen, Fritz, Stephen, Harris, Hoadley, Hewitt, Mitzie, Holguin, Fernando, Hudes, Golda, Jackson, Richard, Kaufman, Alan, Kaufman, David, Klapholz, Ari, Krishna, Harshavardhan, Lee, Daria, Lin, Robert, Maselli-Caceres, Diego, Mehta, Vinay, Moy, James N., Nwokoro, Ugo, Parikh, Purvi, Parikh, Sudhir, Perrino, Frank, Ruhlmann, James, Sassoon, Catherine, Settipane, Russell A., Sousa, Daniel, Sriram, Peruvemba, Wachs, Richard, Ding, Bo, Chen, Stephanie, Quinton, Anna, Cook, William, and Reddel, Helen K.

Published
2024
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5. A pragmatic cluster randomized controlled trial of early intervention for chronic obstructive pulmonary disease by practice nurse-general practitioner teams: Study Protocol

Author

Bunker Jeremy M, Reddel Helen K, Dennis Sarah M, Middleton Sandy, Van Schayck CP, Crockett Alan J, Hasan Iqbal, Hermiz Oshana, Vagholkar Sanjyot, Marks Guy B, and Zwar Nicholas A

Subjects
Medicine (General), R5-920
Abstract

Abstract Background Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of disability, hospitalization, and premature mortality. General practice is well placed to diagnose and manage COPD, but there is a significant gap between evidence and current practice, with a low level of awareness and implementation of clinical practice guidelines. Under-diagnosis of COPD is a world-wide problem, limiting the benefit that could potentially be achieved through early intervention strategies such as smoking cessation, dietary advice, and exercise. General practice is moving towards more structured chronic disease management, and the increasing involvement of practice nurses in delivering chronic care. Design A pragmatic cluster randomised trial will test the hypothesis that intervention by a practice nurse-general practitioner (GP) team leads to improved health-related quality of life and greater adherence with clinical practice guidelines for patients with newly-diagnosed COPD, compared with usual care. Forty general practices in greater metropolitan Sydney Australia will be recruited to identify patients at risk of COPD and invite them to attend a case finding appointment. Practices will be randomised to deliver either practice nurse-GP partnership care, or usual care, to patients newly-diagnosed with COPD. The active intervention will involve the practice nurse and GP working in partnership with the patient in developing and implementing a care plan involving (as appropriate), smoking cessation, immunisation, pulmonary rehabilitation, medication review, assessment and correction of inhaler technique, nutritional advice, management of psycho-social issues, patient education, and management of co-morbidities. The primary outcome measure is health-related quality of life, assessed with the St George’s Respiratory Questionnaire 12 months after diagnosis. Secondary outcome measures include validated disease-specific and general health related quality of life measures, smoking and immunisation status, medications, inhaler technique, and lung function. Outcomes will be assessed by project officers blinded to patients’ randomization groups. Discussion This study will use proven case-finding methods to identify patients with undiagnosed COPD in general practice, where improved care has the potential for substantial benefit in health and healthcare utilization. The study provides the capacity to trial a new model of team-based assessment and management of newly diagnosed COPD in Australian primary care. Trial registration ACTRN12610000592044

Published
2012
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6. Experiences of community pharmacists involved in the delivery of a specialist asthma service in Australia

Author

Emmerton Lynne M, Smith Lorraine, LeMay Kate S, Krass Ines, Saini Bandana, Bosnic-Anticevich Sinthia Z, Reddel Helen K, Burton Deborah L, Stewart Kay, and Armour Carol L

Subjects
Pharmacy, Asthma, Disease management service, Experiences, Feedback, Public aspects of medicine, RA1-1270
Abstract

Abstract Background The role of community pharmacists in disease state management has been mooted for some years. Despite a number of trials of disease state management services, there is scant literature into the engagement of, and with, pharmacists in such trials. This paper reports pharmacists’ feedback as providers of a Pharmacy Asthma Management Service (PAMS), a trial coordinated across four academic research centres in Australia in 2009. We also propose recommendations for optimal involvement of pharmacists in academic research. Methods Feedback about the pharmacists’ experiences was sought via their participation in either a focus group or telephone interview (for those unable to attend their scheduled focus group) at one of three time points. A semi-structured interview guide focused discussion on the pharmacists’ training to provide the asthma service, their interactions with health professionals and patients as per the service protocol, and the future for this type of service. Focus groups were facilitated by two researchers, and the individual interviews were shared between three researchers, with data transcribed verbatim and analysed manually. Results Of 93 pharmacists who provided the PAMS, 25 were involved in a focus group and seven via telephone interview. All pharmacists approached agreed to provide feedback. In general, the pharmacists engaged with both the service and research components, and embraced their roles as innovators in the trial of a new service. Some experienced challenges in the recruitment of patients into the service and the amount of research-related documentation, and collaborative patient-centred relationships with GPs require further attention. Specific service components, such as the spirometry, were well received by the pharmacists and their patients. Professional rewards included satisfaction from their enhanced practice, and pharmacists largely envisaged a future for the service. Conclusions The PAMS provided pharmacists an opportunity to become involved in an innovative service delivery model, supported by the researchers, yet trained and empowered to implement the clinical service throughout the trial period and beyond. The balance between support and independence appeared crucial in the pharmacists’ engagement with the trial. Their feedback was overwhelmingly positive, while useful suggestions were identified for future academic trials.

Published
2012
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7. Overall asthma control achieved with budesonide/formoterol maintenance and reliever therapy for patients on different treatment steps

Author

Östlund Ollie, Peterson Stefan, Jenkins Christine R, Humbert Marc, Buhl Roland, Reddel Helen K, Quirce Santiago, Bateman Eric D, Harrison Tim W, O'Byrne Paul M, Sears Malcolm R, and Eriksson Göran S

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Abstract Background Adjusting medication for uncontrolled asthma involves selecting one of several options from the same or a higher treatment step outlined in asthma guidelines. We examined the relative benefit of introducing budesonide/formoterol (BUD/FORM) maintenance and reliever therapy (Symbicort SMART® Turbuhaler®) in patients previously prescribed treatments from Global Initiative for Asthma (GINA) Steps 2, 3 or 4. Methods This is a post hoc analysis of the results of five large clinical trials (>12000 patients) comparing BUD/FORM maintenance and reliever therapy with other treatments categorised by treatment step at study entry. Both current clinical asthma control during the last week of treatment and exacerbations during the study were examined. Results At each GINA treatment step, the proportion of patients achieving target levels of current clinical control were similar or higher with BUD/FORM maintenance and reliever therapy compared with the same or a higher fixed maintenance dose of inhaled corticosteroid/long-acting β2-agonist (ICS/LABA) (plus short-acting β2-agonist [SABA] as reliever), and rates of exacerbations were lower at all treatment steps in BUD/FORM maintenance and reliever therapy versus same maintenance dose ICS/LABA (P < 0.01) and at treatment Step 4 versus higher maintenance dose ICS/LABA (P < 0.001). BUD/FORM maintenance and reliever therapy also achieved significantly higher rates of current clinical control and significantly lower exacerbation rates at most treatment steps compared with a higher maintenance dose ICS + SABA (Steps 2-4 for control and Steps 3 and 4 for exacerbations). With all treatments, the proportion of patients achieving current clinical control was lower with increasing treatment steps. Conclusions BUD/FORM maintenance and reliever therapy may be a preferable option for patients on Steps 2 to 4 of asthma guidelines requiring a more effective treatment and, compared with other fixed dose alternatives, is most effective in the higher treatment steps.

Published
2011
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8. Global access and patient safety in the transition to environmentally friendly respiratory inhalers: the Global Initiative for Asthma perspective

Author

Levy, Mark L, Bateman, Eric D, Allan, Keith, Bacharier, Leonard B, Bonini, Matteo, Boulet, Louis-Philippe, Bourdin, Arnaud, Brightling, Chris, Brusselle, Guy, Buhl, Roland, Chakaya, Muhwa Jeremiah, Cruz, Alvaro A, Drazen, Jeffrey, Ducharme, Francine M, Duijts, Liesbeth, Fleming, Louise, Inoue, Hiromasa, Ko, Fanny W S, Krishnan, Jerry A, Masekela, Refiloe, Mortimer, Kevin, Pitrez, Paulo, Salvi, Sundeep, Sheikh, Aziz, Reddel, Helen K, and Yorgancıoğlu, Arzu

Published
2023
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9. Cluster Analyses From the Real-World NOVELTY Study: Six Clusters Across the Asthma-COPD Spectrum

Author

Olmo, Ricardo del, Anderson, Gary, Reddel, Helen, Rabahi, Marcelo, McIvor, Andrew, Sadatsafavi, Mohsen, Weinreich, Ulla, Burgel, Pierre-Régis, Devouassoux, Gilles, Papi, Alberto, Inoue, Hiromasa, Rendon, Adrián, van den Berge, Maarten, Beasley, Richard, García-Navarro, Alvar Agusti, Faner, Rosa, Olaguibel Rivera, José, Janson, Christer, Bilińska-Izydorczyk, Magdalena, Fagerås, Malin, Fihn-Wikander, Titti, Franzén, Stefan, Keen, Christina, Ostridge, Kristoffer, Chalmers, James, Harrison, Timothy, Pavord, Ian, Price, David, Azim, Adnan, Belton, Laura, Blé, Francois-Xavier, Erhard, Clement, Gairy, Kerry, Hughes, Rod, Lassi, Glenda, Müllerová, Hana, Rapsomaniki, Eleni, Scott, Ian Christopher, Chipps, Bradley, Christenson, Stephanie, Make, Barry, Tomaszewski, Erin, Benhabib, Gabriel, Ruiz, Xavier Bocca, Lisanti, Raul Eduardo, Marino, Gustavo, Mattarucco, Walter, Nogueira, Juan, Parody, Maria, Pascale, Pablo, Rodriguez, Pablo, Silva, Damian, Svetliza, Graciela, Victorio, Carlos F., Rolon, Roxana Willigs, Yañez, Anahi, Baines, Stuart, Bowler, Simon, Bremner, Peter, Bull, Sheetal, Carroll, Patrick, Chaalan, Mariam, Farah, Claude, Hammerschlag, Gary, Hancock, Kerry, Harrington, Zinta, Katsoulotos, Gregory, Kim, Joshua, Langton, David, Lee, Donald, Peters, Matthew, Prassad, Lakshman, Sajkov, Dimitar, Santiago, Francis, Simpson, Frederick Graham, Tai, Sze, Thomas, Paul, Wark, Peter, Cançado, José Eduardo Delfini, Cunha, Thúlio, Lima, Marina, Cardoso, Alexandre Pinto, FitzGerald, J. Mark, Anees, Syed, Bertley, John, Bell, Alan, Cheema, Amarjit, Chouinard, Guy, Csanadi, Michael, Dhar, Anil, Dhillon, Ripple, Kanawaty, David, Kelly, Allan, Killorn, William, Landry, Daniel, Luton, Robert, Mandhane, Piushkumar, Pek, Bonavuth, Petrella, Robert, Stollery, Daniel, Wang, Chen, Chen, Meihua, Chen, Yan, Gu, Wei, Christopher Hui, Kim Ming, Li, Manxiang, Li, Shiyue, Lijun, Ma, Qin, Guangyue, Song, Weidong, Tan, Wei, Tang, Yijun, Wang, Tan, Wen, Fuqiang, Wu, Feng, Xiang, PingChao, Xiao, Zuke, Xiong, Shengdao, Yang, Jinghua, Yang, Jingping, Zhang, Caiqing, Zhang, Min, Zhang, Ping, Zhang, Wei, Zheng, Xiaohe, Zhu, Dan, Bueno, Carlos Matiz, Grimaldos, Fabio Bolivar, Arboleda, Alejandra Cañas, de Salazar, Dora Molina, Bendstrup, Elisabeth, Hilberg, Ole, Kjellerup, Carsten, Raherison, Chantal, Bonniaud, Philippe, Brun, Olivier, Chouaid, Christos, Couturaud, Francis, de Blic, Jacques, Debieuvre, Didier, Delsart, Dominique, Demaegdt, Axelle, Demoly, Pascal, Deschildre, Antoine, Egron, Carole, Falchero, Lionel, Goupil, François, Kessler, Romain, Le Roux, Pascal, Mabire, Pascal, Mahay, Guillaume, Martinez, Stéphanie, Melloni, Boris, Moreau, Laurent, Riviere, Emilie, Roux-Claudé, Pauline, Soulier, Michel, Vignal, Guillaume, Yaici, Azzedine, Bals, Robert, Aries, Sven Philip, Beck, Ekkehard, Deimling, Andreas, Feimer, Jan, Grimm-Sachs, Vera, Groth, Gesine, Herth, Felix, Hoheisel, Gerhard, Kanniess, Frank, Lienert, Thomas, Mronga, Silke, Reinhardt, Jörg, Schlenska, Christian, Stolpe, Christoph, Teber, Ishak, Timmermann, Hartmut, Ulrich, Thomas, Velling, Peter, Wehgartner-Winkler, Sabina, Welling, Juergen, Winkelmann, Ernst-Joachim, Barbetta, Carlo, Braido, Fulvio, Cardaci, Vittorio, Clini, Enrico Maria, Costantino, Maria Teresa, Cuttitta, Giuseppina, di Gioacchino, Mario, Fois, Alessandro, Foschino-Barbaro, Maria Pia, Gammeri, Enrico, Inchingolo, Riccardo, Lavorini, Federico, Molino, Antonio, Nucera, Eleonora, Patella, Vincenzo, Pesci, Alberto, Ricciardolo, Fabio, Rogliani, Paola, Sarzani, Riccardo, Vancheri, Carlo, Vincenti, Rigoletta, Endo, Takeo, Fujita, Masaki, Hara, Yu, Horiguchi, Takahiko, Hosoi, Keita, Ide, Yumiko, Inomata, Minehiko, Inoue, Koji, Inoue, Sumito, Kato, Motokazu, Kawasaki, Masayuki, Kawayama, Tomotaka, Kita, Toshiyuki, Kobayashi, Kanako, Koto, Hiroshi, Nishi, Koichi, Saito, Junpei, Shimizu, Yasuo, Shirai, Toshihiro, Sugihara, Naruhiko, Takahashi, Ken-ichi, Tashimo, Hiroyuki, Tomii, Keisuke, Yamada, Takashi, Yanai, Masaru, Rendon, Adrian, Cerino Javier, Ruth, Domínguez Peregrina, Alfredo, Fernández Corzo, Marco, Montano Gonzalez, Efraín, Ramírez-Venegas, Alejandra, Boersma, Willem, Djamin, R.S., Eijsvogel, Michiel, Franssen, Frits, Goosens, Martijn, Graat-Verboom, Lidwien, Veen, Johannes in 't, Janssen, Rob, Kuppens, Kim, van de Ven, Mario, Bakke, Per, Brunstad, Ole Petter, Einvik, Gunnar, Høines, Kristian Jong, Khusrawi, Alamdar, Oien, Torbjorn, Yoon, Ho Joo, Chang, Yoon-Seok, Cho, Young Joo, Hwang, Yong Il, Kim, Woo Jin, Koh, Young-Il, Lee, Byung-Jae, Lee, Kwan-Ho, Lee, Sang-Pyo, Lee, Yong Chul, Lim, Seong Yong, Min, Kyung Hun, Oh, Yeon-Mok, Park, Choon-Sik, Park, Hae-Sim, Park, Heung-Woo, Rhee, Chin Kook, Yoon, Hyoung-Kyu, García-Navarro, Alvar Agustí, Andújar, Rubén, Anoro, Laura, Buendía García, María, Mozo, Paloma Campo, Campos, Sergio, Casas Maldonado, Francisco, Castilla Martínez, Manuel, Cisneros Serrano, Carolina, Comeche Casanova, Lorena, Corbacho, Dolores, Campo Matías, Felix Del, Echave-Sustaeta, Jose, Corral, Gloria Francisco, Gamboa Setién, Pedro, García Clemente, Marta, Núñez, Ignacio García, García Robaina, Jose, García Salmones, Mercedes, Marín Trigo, Jose Maria, Fernandez, Marta Nuñez, Palomo, Sara Nuñez, Pérez de Llano, Luis, Pueyo Bastida, Ana, Rañó, Ana, Rodríguez González-Moro, José, Reig, Albert Roger, Velasco Garrido, José, Curiac, Dan, Lif-Tiberg, Cornelia, Luts, Anders, Råhlen, Lennart, Rustscheff, Stefan, Adams, Frances, Bradman, Drew, Broughton, Emma, Cosgrove, John, Flood-Page, Patrick, Fuller, Elizabeth, Hartley, David, Hattotuwa, Keith, Jones, Gareth, Lewis, Keir, McGarvey, Lorcan, Morice, Alyn, Pandya, Preeti, Patel, Manish, Roy, Kay, Sathyamurthy, Ramamurthy, Thiagarajan, Swaminathan, Turner, Alice, Vestbo, Jørgen, Wedzicha, Wisia, Wilkinson, Tom, Wilson, Pete, Al-Asadi, Lo’Ay, Anholm, James, Averill, Francis, Bansal, Sandeep, Baptist, Alan, Campbell, Colin, Campos, Michael A., Crook, Gretchen, DeLeon, Samuel, Eid, Alain, Epstein, Ellen, Fritz, Stephen, Harris, Hoadley, Hewitt, Mitzie, Holguin, Fernando, Hudes, Golda, Jackson, Richard, Kaufman, Alan, Kaufman, David, Klapholz, Ari, Krishna, Harshavardhan, Lee, Daria, Lin, Robert, Maselli-Caceres, Diego, Mehta, Vinay, Moy, James N., Nwokoro, Ugo, Parikh, Purvi, Parikh, Sudhir, Perrino, Frank, Ruhlmann, James, Sassoon, Catherine, Settipane, Russell A., Sousa, Daniel, Sriram, Peruvemba, Wachs, Richard, Bansal, Aruna T., Agustí, Alvar, Fageras, Malin, Alacqua, Marianna, and Reddel, Helen K.

Published
2023
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10. Diagnostic Performance of a Machine Learning Algorithm (Asthma/Chronic Obstructive Pulmonary Disease [COPD] Differentiation Classification) Tool Versus Primary Care Physicians and Pulmonologists in Asthma, COPD, and Asthma/COPD Overlap

Author

Kocks, Janwillem W.H., Cao, Hui, Holzhauer, Björn, Kaplan, Alan, FitzGerald, J. Mark, Kostikas, Konstantinos, Price, David, Reddel, Helen K., Tsiligianni, Ioanna, Vogelmeier, Claus F., Bostel, Sebastien, and Mastoridis, Paul

Published
2023
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12. Comorbidities Modify the Phenotype but Not the Treatment Effectiveness to Mepolizumab in Severe Eosinophilic Asthma

Author

Baraket, Melissa, Bardin, Philip, Bowden, Jeffrey J., Bowler, Simon, Chien, Jimmy, Chung, Li Ping, Grainge, Christopher, Harkness, Nicholas, Harrington, Zinta, Jenkins, Christine, Katsoulotos, Gregory P., McDonald, Vanessa M., Lee, Joy, Peters, Matthew, Reddel, Helen K., Reynolds, Paul N., Sivakumaran, Pathmanathan, Upham, John W., Wark, Peter A.B., Kritikos, Vicky, Harvey, Erin S., Stevens, Sean, Katelaris, Constance H., Langton, David, Rimmer, Janet, Farah, Claude S., Gillman, Andrew, Hew, Mark, Radhakrishna, Naghmeh, Thomas, Dennis, and Gibson, Peter G.

Published
2023
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13. The burden of mild asthma: Clinical burden and healthcare resource utilisation in the NOVELTY study

Author

Benhabib, Gabriel, Mandhane, Piushkumar, Ruiz, Xavier Bocca, McIvor, Andrew, Olmo, Ricardo del, Pek, Bonavuth, Lisanti, Raul Eduardo, Petrella, Robert, Marino, Gustavo, Stollery, Daniel, Mattarucco, Walter, Chen, Meihua, Nogueira, Juan, Chen, Yan, Parody, Maria, Gu, Wei, Pascale, Pablo, Hui, Kim Ming Christopher, Rodriguez, Pablo, Li, Manxiang, Silva, Damian, Li, Shiyue, Svetliza, Graciela, Ma, Lijun, Victorio, Carlos F., Qin, Guangyue, Rolon, Roxana Willigs, Song, Weidong, Yañez, Anahi, Tan, Wei, Baines, Stuart, Tang, Yijun, Bowler, Simon, Wang, Chen, Bremner, Peter, Wang, Tan, Bull, Sheetal, Wen, Fuqiang, Carroll, Patrick, Wu, Feng, Chaalan, Mariam, Xiang, PingChao, Farah, Claude, Xiao, Zuke, Hammerschlag, Gary, Xiong, Shengdao, Hancock, Kerry, Yang, Jinghua, Harrington, Zinta, Yang, Jingping, Katsoulotos, Gregory, Zhang, Caiqing, Kim, Joshua, Zhang, Min, Langton, David, Zhang, Ping, Lee, Donald, Zhang, Wei, Peters, Matthew, Zheng, Xiaohe, Prassad, Lakshman, Zhu, Dan, Reddel, Helen, Bolivar Grimaldos, Fabio, Sajkov, Dimitar, Arboleda, Alejandra Cañas, Santiago, Francis, Bueno, Carlos Matiz, Simpson, Frederick Graham, Molina de Salazar, Dora, Tai, Sze, Bendstrup, Elisabeth, Thomas, Paul, Hilberg, Ole, Wark, Peter, Kjellerup, Carsten, Cançado, José Eduardo Delfini, Weinreich, Ulla, Cunha, Thúlio, Bonniaud, Philippe, Lima, Marina, Brun, Olivier, Cardoso, Alexandre Pinto, Burgel, Pierre-Régis, Rabahi, Marcelo, Chouaid, Christos, Anees, Syed, Couturaud, Francis, Bertley, John, de Blic, Jacques, Bell, Alan, Debieuvre, Didier, Cheema, Amarjit, Delsart, Dominique, Chouinard, Guy, Demaegdt, Axelle, Csanadi, Michael, Demoly, Pascal, Dhar, Anil, Deschildre, Antoine, Dhillon, Ripple, Devouassoux, Gilles, FitzGerald, J. Mark, Egron, Carole, Kanawaty, David, Falchero, Lionel, Kelly, Allan, Goupil, François, Killorn, William, Kessler, Romain, Landry, Daniel, Le Roux, Pascal, Luton, Robert, Mabire, Pascal, Mahay, Guillaume, Ide, Yumiko, Martinez, Stéphanie, Inomata, Minehiko, Melloni, Boris, Inoue, Hiromasa, Moreau, Laurent, Inoue, Koji, Raherison, Chantal, Inoue, Sumito, Riviere, Emilie, Kato, Motokazu, Roux-Claudé, Pauline, Kawasaki, Masayuki, Soulier, Michel, Kawayama, Tomotaka, Vignal, Guillaume, Kita, Toshiyuki, Yaici, Azzedine, Kobayashi, Kanako, Aries, Sven Philip, Koto, Hiroshi, Bals, Robert, Nishi, Koichi, Beck, Ekkehard, Saito, Junpei, Deimling, Andreas, Shimizu, Yasuo, Feimer, Jan, Shirai, Toshihiro, Grimm-Sachs, Vera, Sugihara, Naruhiko, Groth, Gesine, Takahashi, Ken-ichi, Herth, Felix, Tashimo, Hiroyuki, Hoheisel, Gerhard, Tomii, Keisuke, Kanniess, Frank, Yamada, Takashi, Lienert, Thomas, Yanai, Masaru, Mronga, Silke, Javier, Ruth Cerino, Reinhardt, Jörg, Domínguez Peregrina, Alfredo, Schlenska, Christian, Corzo, Marco Fernández, Stolpe, Christoph, Montano Gonzalez, Efraín, Teber, Ishak, Ramírez-Venegas, Alejandra, Timmermann, Hartmut, Rendon, Adrian, Ulrich, Thomas, Boersma, Willem, Velling, Peter, Djamin, R.S., Wehgartner-Winkler, Sabina, Eijsvogel, Michiel, Welling, Juergen, Franssen, Frits, Winkelmann, Ernst-Joachim, Goosens, Martijn, Barbetta, Carlo, Graat-Verboom, Lidwien, Braido, Fulvio, Veen, Johannes in 't, Cardaci, Vittorio, Janssen, Rob, Clini, Enrico Maria, Kuppens, Kim, Costantino, Maria Teresa, van den Berge, Maarten, Cuttitta, Giuseppina, van de Ven, Mario, di Gioacchino, Mario, Brunstad, Ole Petter, Fois, Alessandro, Einvik, Gunnar, Foschino-Barbaro, Maria Pia, Høines, Kristian Jong, Gammeri, Enrico, Khusrawi, Alamdar, Inchingolo, Riccardo, Oien, Torbjorn, Lavorini, Federico, Chang, Yoon-Seok, Molino, Antonio, Cho, Young Joo, Nucera, Eleonora, Hwang, Yong Il, Papi, Alberto, Kim, Woo Jin, Patella, Vincenzo, Koh, Young-Il, Pesci, Alberto, Lee, Byung-Jae, Ricciardolo, Fabio, Lee, Kwan-Ho, Rogliani, Paola, Lee, Sang-Pyo, Sarzani, Riccardo, Lee, Yong Chul, Vancheri, Carlo, Lim, Seong Yong, Vincenti, Rigoletta, Min, Kyung Hun, Endo, Takeo, Oh, Yeon-Mok, Fujita, Masaki, Park, Choon-Sik, Hara, Yu, Park, Hae-Sim, Horiguchi, Takahiko, Park, Heung-Woo, Hosoi, Keita, Rhee, Chin Kook, Yoon, Ho Joo, Morice, Alyn, Yoon, Hyoung-Kyu, Pandya, Preeti, García-Navarro, Alvar Agusti, Patel, Manish, Andújar, Rubén, Roy, Kay, Anoro, Laura, Sathyamurthy, Ramamurthy, García, María Buendía, Thiagarajan, Swaminathan, Mozo, Paloma Campo, Turner, Alice, Campos, Sergio, Vestbo, Jorgen, Maldonado, Francisco Casas, Wedzicha, Wisia, Castilla Martínez, Manuel, Wilkinson, Tom, Serrano, Carolina Cisneros, Wilson, Pete, Comeche Casanova, Lorena, Al-Asadi, Lo’Ay, Corbacho, Dolores, Anholm, James, Campo Matías, Felix Del, Averill, Frank, Echave-Sustaeta, Jose, Bansal, Sandeep, Corral, Gloria Francisco, Baptist, Alan, Gamboa Setién, Pedro, Campbell, Colin, García Clemente, Marta, Campos, Michael A., Núñez, Ignacio García, Chipps, Bradley, Robaina, Jose García, Crook, Gretchen, García Salmones, Mercedes, DeLeon, Samuel, Marín Trigo, Jose Maria, Eid, Alain, Fernandez, Marta Nuñez, Epstein, Ellen, Palomo, Sara Nuñez, Fritz, Stephen, Olaguibel Rivera, José, Harris, Hoadley, de Llano, Luis Pérez, Hewitt, Mitzie, Pueyo Bastida, Ana, Holguin, Fernando, Rañó, Ana, Hudes, Golda, Rodríguez González-Moro, José, Jackson, Richard, Reig, Albert Roger, Kaufman, Alan, Velasco Garrido, José, Kaufman, David, Curiac, Dan, Klapholz, Ari, Janson, Christer, Krishna, Harshavardhan, Lif-Tiberg, Cornelia, Lee, Daria, Luts, Anders, Lin, Robert, Råhlen, Lennart, Maselli-Caceres, Diego, Rustscheff, Stefan, Mehta, Vinay, Adams, Frances, Moy, James N., Bradman, Drew, Nwokoro, Ugo, Broughton, Emma, Parikh, Purvi, Cosgrove, John, Parikh, Sudhir, Flood-Page, Patrick, Perrino, Frank, Fuller, Elizabeth, Ruhlmann, James, Harrison, Timothy, Sassoon, Catherine, Hartley, David, Settipane, Russell A., Hattotuwa, Keith, Sousa, Daniel, Jones, Gareth, Sriram, Peruvemba, Lewis, Keir, Wachs, Richard, McGarvey, Lorcan, Golam, Sarowar Muhammad, Beasley, Richard, FitzGerald, J Mark, Harrison, Tim, Hughes, Rod, Müllerová, Hana, Olaguibel, José María, Rapsomaniki, Eleni, Reddel, Helen K., and Sadatsafavi, Mohsen

Published
2022
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14. Frequent productive cough: Symptom burden and future exacerbation risk among patients with asthma and/or COPD in the NOVELTY study

Author

Benhabib, Gabriel, Ruiz, Xavier Bocca, Olmo, Ricardo del, Lisanti, Raul Eduardo, Marino, Gustavo, Mattarucco, Walter, Nogueira, Juan, Parody, Maria, Pascale, Pablo, Rodriguez, Pablo, Silva, Damian, Svetliza, Graciela, Victorio, Carlos F., Rolon, Roxana Willigs, Yañez, Anahi, Baines, Stuart, Bowler, Simon, Bremner, Peter, Bull, Sheetal, Carroll, Patrick, Chaalan, Mariam, Farah, Claude, Hammerschlag, Gary, Hancock, Kerry, Harrington, Zinta, Katsoulotos, Gregory, Kim, Joshua, Langton, David, Lee, Donald, Peters, Matthew, Prassad, Lakshman, Reddel, Helen, Sajkov, Dimitar, Santiago, Francis, Simpson, Frederick Graham, Tai, Sze, Thomas, Paul, Wark, Peter, Delfini Cançado, José Eduardo, Cunha, Thúlio, Lima, Marina, Cardoso, Alexandre Pinto, Rabahi, Marcelo, Anees, Syed, Bertley, John, Bell, Alan, Cheema, Amarjit, Chouinard, Guy, Csanadi, Michael, Dhar, Anil, Dhillon, Ripple, FitzGerald, J. Mark, Kanawaty, David, Kelly, Allan, Killorn, William, Landry, Daniel, Luton, Robert, Mandhane, Piushkumar, McIvor, Andrew, Pek, Bonavuth, Petrella, Robert, Stollery, Daniel, Chen, Meihua, Chen, Yan, Gu, Wei, Christopher Hui, Kim Ming, Li, Manxiang, Li, Shiyue, Lijun, Ma, Qin, Guangyue, Song, Weidong, Tan, Wei, Tang, Yijun, Wang, Chen, Wang, Tan, Wen, Fuqiang, Wu, Feng, Xiang, PingChao, Xiao, Zuke, Xiong, Shengdao, Yang, Jinghua, Yang, Jingping, Zhang, Caiqing, Zhang, Min, Zhang, Ping, Zhang, Wei, Zheng, Xiaohe, Zhu, Dan, Grimaldos, Fabio Bolivar, Arboleda, Alejandra Cañas, Bueno, Carlos Matiz, Molina de Salazar, Dora, Bendstrup, Elisabeth, Hilberg, Ole, Kjellerup, Carsten, Weinreich, Ulla, Bonniaud, Philippe, Brun, Olivier, Burgel, Pierre-Régis, Chouaid, Christos, Couturaud, Francis, de Blic, Jacques, Debieuvre, Didier, Delsart, Dominique, Demaegdt, Axelle, Demoly, Pascal, Deschildre, Antoine, Devouassoux, Gilles, Egron, Carole, Falchero, Lionel, Goupil, François, Kessler, Romain, Le Roux, Pascal, Mabire, Pascal, Mahay, Guillaume, Martinez, Stéphanie, Melloni, Boris, Moreau, Laurent, Raherison, Chantal, Riviere, Emilie, Roux-Claudé, Pauline, Soulier, Michel, Vignal, Guillaume, Yaici, Azzedine, Aries, Sven Philip, Bals, Robert, Beck, Ekkehard, Deimling, Andreas, Feimer, Jan, Grimm-Sachs, Vera, Groth, Gesine, Herth, Felix, Hoheisel, Gerhard, Kanniess, Frank, Lienert, Thomas, Mronga, Silke, Reinhardt, Jörg, Schlenska, Christian, Stolpe, Christoph, Teber, Ishak, Timmermann, Hartmut, Ulrich, Thomas, Velling, Peter, Wehgartner-Winkler, Sabina, Welling, Juergen, Winkelmann, Ernst-Joachim, Barbetta, Carlo, Braido, Fulvio, Cardaci, Vittorio, Clini, Enrico Maria, Costantino, Maria Teresa, Cuttitta, Giuseppina, di Gioacchino, Mario, Fois, Alessandro, Foschino-Barbaro, Maria Pia, Gammeri, Enrico, Inchingolo, Riccardo, Lavorini, Federico, Molino, Antonio, Nucera, Eleonora, Papi, Alberto, Patella, Vincenzo, Pesci, Alberto, Ricciardolo, Fabio, Rogliani, Paola, Sarzani, Riccardo, Vancheri, Carlo, Vincenti, Rigoletta, Endo, Takeo, Fujita, Masaki, Hara, Yu, Horiguchi, Takahiko, Hosoi, Keita, Ide, Yumiko, Inomata, Minehiko, Inoue, Hiromasa, Inoue, Koji, Inoue, Sumito, Kato, Motokazu, Kawasaki, Masayuki, Kawayama, Tomotaka, Kita, Toshiyuki, Kobayashi, Kanako, Koto, Hiroshi, Nishi, Koichi, Saito, Junpei, Shimizu, Yasuo, Shirai, Toshihiro, Sugihara, Naruhiko, Takahashi, Ken-ichi, Tashimo, Hiroyuki, Tomii, Keisuke, Yamada, Takashi, Yanai, Masaru, Javier, Ruth Cerino, Peregrina, Alfredo Domínguez, Corzo, Marco Fernández, Gonzalez, Efraín Montano, Ramírez-Venegas, Alejandra, Rendon, Adrian, Boersma, Willem, Djamin, R.S., Eijsvogel, Michiel, Franssen, Frits, Goosens, Martijn, Graat-Verboom, Lidwien, Veen, Johannes in 't, Janssen, Rob, Kuppens, Kim, van den Berge, Maarten, van de Ven, Mario, Brunstad, Ole Petter, Einvik, Gunnar, Høines, Kristian Jong, Khusrawi, Alamdar, Oien, Torbjorn, Chang, Yoon-Seok, Cho, Young Joo, Hwang, Yong Il, Kim, Woo Jin, Koh, Young-Il, Lee, Byung-Jae, Lee, Kwan-Ho, Lee, Sang-Pyo, Lee, Yong Chul, Lim, Seong Yong, Min, Kyung Hun, Oh, Yeon-Mok, Park, Choon-Sik, Park, Hae-Sim, Park, Heung-Woo, Rhee, Chin Kook, Yoon, Ho Joo, Yoon, Hyoung-Kyu, García-Navarro, Alvar Agusti, Andújar, Rubén, Anoro, Laura, García, María Buendía, Mozo, Paloma Campo, Campos, Sergio, Maldonado, Francisco Casas, Martínez, Manuel Castilla, Serrano, Carolina Cisneros, Casanova, Lorena Comeche, Corbacho, Dolores, Del Campo Matías, Felix, Echave-Sustaeta, Jose, Corral, Gloria Francisco, Setién, Pedro Gamboa, Clemente, Marta García, Núñez, Ignacio García, Robaina, Jose García, Salmones, Mercedes García, Marín Trigo, Jose Maria, Fernandez, Marta Nuñez, Palomo, Sara Nuñez, Rivera, José Olaguibel, Pérez de Llano, Luis, Bastida, Ana Pueyo, Rañó, Ana, González-Moro, José Rodríguez, Reig, Albert Roger, Garrido, José Velasco, Curiac, Dan, Janson, Christer, Lif-Tiberg, Cornelia, Luts, Anders, Råhlen, Lennart, Rustscheff, Stefan, Adams, Frances, Bradman, Drew, Broughton, Emma, Cosgrove, John, Flood-Page, Patrick, Fuller, Elizabeth, Harrison, Timothy, Hartley, David, Hattotuwa, Keith, Jones, Gareth, Lewis, Keir, McGarvey, Lorcan, Morice, Alyn, Pandya, Preeti, Patel, Manish, Roy, Kay, Sathyamurthy, Ramamurthy, Thiagarajan, Swaminathan, Turner, Alice, Vestbo, Jorgen, Wedzicha, Wisia, Wilkinson, Tom, Wilson, Pete, Al-Asadi, Lo’Ay, Anholm, James, Averill, Frank, Bansal, Sandeep, Baptist, Alan, Campbell, Colin, Campos, Michael A., Chipps, Bradley, Crook, Gretchen, DeLeon, Samuel, Eid, Alain, Epstein, Ellen, Fritz, Stephen, Harris, Hoadley, Hewitt, Mitzie, Holguin, Fernando, Hudes, Golda, Jackson, Richard, Kaufman, Alan, Kaufman, David, Klapholz, Ari, Krishna, Harshavardhan, Lee, Daria, Lin, Robert, Maselli-Caceres, Diego, Mehta, Vinay, Moy, James N., Nwokoro, Ugo, Parikh, Purvi, Parikh, Sudhir, Perrino, Frank, Ruhlmann, James, Sassoon, Catherine, Settipane, Russell A., Sousa, Daniel, Sriram, Peruvemba, Wachs, Richard, Hughes, Rod, Rapsomaniki, Eleni, Keen, Christina, Make, Barry J., Tomaszewski, Erin L., Müllerová, Hana, and Reddel, Helen K.

Published
2022
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15. Prevalence and burden of difficult‐to‐treat and severe asthma in Australia: A national population survey.

Author

Davis, Sharon R., Ampon, Rosario D., Poulos, Leanne M., Lee, Taehoon, Marks, Guy B., Toelle, Brett G., and Reddel, Helen K.

Subjects
DEMOGRAPHIC surveys, EMERGENCY room visits, ASTHMA, ASTHMATICS, COVID-19, WHEEZE, ANXIETY sensitivity, FEAR of dentists
Abstract

Background and Objective: Most evidence about difficult‐to‐treat and severe asthma (DTTA) comes from clinical trials and registries. We aimed to identify people with DTTA from a large nationally representative asthma population and describe their characteristics and healthcare utilization compared with people whose asthma was not 'difficult‐to‐treat'. Methods: We conducted a cross‐sectional survey of Australians aged ≥18 years with current asthma from large web‐based survey panels. Enrolment was stratified by gender, age‐group and state/territory based on national population data for people with asthma. Difficult‐to‐treat or severe asthma was defined by poor symptom control, exacerbations and/or oral corticosteroid/biologic use despite medium/high‐dose inhaled therapy. Outcomes included exacerbations, healthcare utilization, multimorbidity, quality of life and coronavirus disease of 2019 (COVID‐19)‐related behaviour. Weighted data were analysed using SAS version 9.4. Results: The survey was conducted in February–March 2021. The weighted sample comprised 6048 adults with current asthma (average age 47.3 ± SD 18.1 years, 59.9% female), with 1313 (21.7%) satisfying ≥1 DTTA criteria. Of these, 50.4% had very poorly controlled symptoms (Asthma Control Test ≤15), 36.2% were current smokers, and 85.4% had ≥1 additional chronic condition, most commonly anxiety/depression. More than twice as many participants with DTTA versus non‐DTTA had ≥1 urgent general practitioner (GP) visit (61.4% vs. 27.5%, OR 4.8 [4.2–5.5, p < 0.0001]), or ≥1 emergency room visit (41.9% vs. 17.9%, OR 3.8 [3.3–4.4, p < 0.0001]) in the previous 12 months. Conclusion: Our findings emphasize the burden of uncontrolled symptoms, current smoking, multimorbidity and healthcare utilization in people with DTTA in the community, who may be under‐represented in registries or clinical trials. In this cross‐sectional study of a nationally‐representative population of 6048 adults with current asthma, 21.7% had difficult‐to‐treat asthma. Burden for patients and health system was seen in poor general health status, poor asthma symptom control, frequent urgent GP and emergency department (ED)/hospital visits and high prevalence of multimorbidity, particularly anxiety and/or depression. See relatededitorial [ABSTRACT FROM AUTHOR]

Published
2024
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17. Global Initiative for Asthma Strategy 2021: Executive Summary and Rationale for Key Changes

Author

Reddel, Helen K., Bacharier, Leonard B., Bateman, Eric D., Brightling, Christopher E., Brusselle, Guy G., Buhl, Roland, Cruz, Alvaro A., Duijts, Liesbeth, Drazen, Jeffrey M., FitzGerald, J. Mark, Fleming, Louise J., Inoue, Hiromasa, Ko, Fanny W., Krishnan, Jerry A., Levy, Mark L., Lin, Jiangtao, Mortimer, Kevin, Pitrez, Paulo M., Sheikh, Aziz, Yorgancioglu, Arzu A., and Boulet, Louis-Philippe

Published
2022
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20. Mepolizumab and Oral Corticosteroid Stewardship: Data from the Australian Mepolizumab Registry

Author

Thomas, Dennis, Harvey, Erin S., McDonald, Vanessa M., Stevens, Sean, Upham, John W., Katelaris, Constance H., Kritikos, Vicky, Gillman, Andrew, Harrington, John, Hew, Mark, Bardin, Philip, Peters, Matthew, Reynolds, Paul N., Langton, David, Baraket, Melissa, Bowden, Jeffrey J., Bowler, Simon, Chien, Jimmy, Chung, Li Ping, Farah, Claude S., Grainge, Christopher, Jenkins, Christine, Katsoulotos, Gregory P., Lee, Joy, Radhakrishna, Naghmeh, Reddel, Helen K., Rimmer, Janet, Sivakumaran, Pathmanathan, Wark, Peter A.B., and Gibson, Peter G.

Published
2021
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23. American Thoracic Society/National Heart, Lung, and Blood Institute Asthma-Chronic Obstructive Pulmonary Disease Overlap Workshop Report.

Author

Woodruff, Prescott G, van den Berge, Maarten, Boucher, Richard C, Brightling, Christopher, Burchard, Esteban G, Christenson, Stephanie A, Han, MeiLan K, Holtzman, Michael J, Kraft, Monica, Lynch, David A, Martinez, Fernando D, Reddel, Helen K, Sin, Don D, Washko, George R, Wenzel, Sally E, Punturieri, Antonello, Freemer, Michelle M, and Wise, Robert A

Subjects
Lung, Asthma, Pulmonary Disease, Chronic Obstructive, Diagnostic Imaging, Societies, Medical, United States, National Heart, Lung, and Blood Institute (U.S.), asthma, chronic obstructive pulmonary disease, overlap, Clinical Research, Chronic Obstructive Pulmonary Disease, Respiratory, Medical and Health Sciences, Respiratory System
Abstract

Asthma and chronic obstructive pulmonary disease (COPD) are highly prevalent chronic obstructive lung diseases with an associated high burden of disease. Asthma, which is often allergic in origin, frequently begins in infancy or childhood with variable airflow obstruction and intermittent wheezing, cough, and dyspnea. Patients with COPD, in contrast, are usually current or former smokers who present after the age of 40 years with symptoms (often persistent) including dyspnea and a productive cough. On the basis of age and smoking history, it is often easy to distinguish between asthma and COPD. However, some patients have features compatible with both diseases. Because clinical studies typically exclude these patients, their underlying disease mechanisms and appropriate treatment remain largely uncertain. To explore the status of and opportunities for research in this area, the NHLBI, in partnership with the American Thoracic Society, convened a workshop of investigators in San Francisco, California on May 14, 2016. At the workshop, current understanding of asthma-COPD overlap was discussed among clinicians, pathologists, radiologists, epidemiologists, and investigators with expertise in asthma and COPD. They considered knowledge gaps in our understanding of asthma-COPD overlap and identified strategies and research priorities that will advance its understanding. This report summarizes those discussions.

Published
2017

25. Predictive value of blood eosinophils and exhaled nitric oxide in adults with mild asthma: a prespecified subgroup analysis of an open-label, parallel-group, randomised controlled trial

Author

Corin, Andrew, Helm, Colin, Poudel, Bhuwan, Sheahan, Davitt, Sheahan, Pamela, Bennett, Miriam, Chang, Caterina, Ellis, Hollie, Hancox, Bob, Hopping, Sandra, Tuffery, Christine, Ramsahai, James Michael, Simpson, Jodie, Wark, Peter, Aliani, Maria, Genco, Maddalena, Capozzolo, Alberto, Carone, Mauro, Maini, Elisa, Mancin, Jenny, Meriggi, Antonio, Perfetti, Luca, Cherubino, Francesca, Spanevello, Antonio, Visca, Dina, Zampogna, Elisabetta, Baggott, Christina, Beasley, Richard, Braithwaite, Irene, Eathorne, Allie, Ebmeier, Stefan, Fingleton, James, Hardy, Jo, Holliday, Mark, Houghton, Claire, Oldfield, Karen, Pilcher, Janine, Sabbagh, Donah, Semprini, Alex, Williams, Mathew, Harrison, Tim, Shaw, Karen, Mackisack, Summer, Montgomery, Barney, Autridge, Karen, Joseph, Joanna, Moon, Stella, Quinn, Dean, Millar-Coote, Dean, Reid, Jim, Bellini, Federico, Marchi, Martina, Morandi, Luca, Padovani, Marianna, Papi, Alberto, Scalet, Daniela, Borg, Katie, Connolly, Clare, Gittins, Anna, Hynes, Gareth, Jeffers, Helen, Pavord, Ian, Shrimanker, Rahul, Foxley, Gloria, Guevara-Rattray, Elyse, Milne, Stephen, Reddel, Helen, Toelle, Brett, Pavord, Ian D, Reddel, Helen K, Hancox, Robert J, and Weatherall, Mark

Published
2020
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33. Cluster Analyses From the Real-World NOVELTY Study: Six Clusters Across the Asthma-COPD Spectrum

Author

Hughes, Rod, primary, Rapsomaniki, Eleni, additional, Bansal, Aruna T., additional, Vestbo, Jørgen, additional, Price, David, additional, Agustí, Alvar, additional, Beasley, Richard, additional, Fageras, Malin, additional, Alacqua, Marianna, additional, Papi, Alberto, additional, Müllerová, Hana, additional, Reddel, Helen K., additional, Olmo, Ricardo del, additional, Anderson, Gary, additional, Reddel, Helen, additional, Rabahi, Marcelo, additional, McIvor, Andrew, additional, Sadatsafavi, Mohsen, additional, Weinreich, Ulla, additional, Burgel, Pierre-Régis, additional, Devouassoux, Gilles, additional, Inoue, Hiromasa, additional, Rendon, Adrián, additional, van den Berge, Maarten, additional, García-Navarro, Alvar Agusti, additional, Faner, Rosa, additional, Olaguibel Rivera, José, additional, Janson, Christer, additional, Bilińska-Izydorczyk, Magdalena, additional, Fagerås, Malin, additional, Fihn-Wikander, Titti, additional, Franzén, Stefan, additional, Keen, Christina, additional, Ostridge, Kristoffer, additional, Chalmers, James, additional, Harrison, Timothy, additional, Pavord, Ian, additional, Azim, Adnan, additional, Belton, Laura, additional, Blé, Francois-Xavier, additional, Erhard, Clement, additional, Gairy, Kerry, additional, Hughes, Rod, additional, Lassi, Glenda, additional, Scott, Ian Christopher, additional, Chipps, Bradley, additional, Christenson, Stephanie, additional, Make, Barry, additional, Tomaszewski, Erin, additional, Benhabib, Gabriel, additional, Ruiz, Xavier Bocca, additional, Lisanti, Raul Eduardo, additional, Marino, Gustavo, additional, Mattarucco, Walter, additional, Nogueira, Juan, additional, Parody, Maria, additional, Pascale, Pablo, additional, Rodriguez, Pablo, additional, Silva, Damian, additional, Svetliza, Graciela, additional, Victorio, Carlos F., additional, Rolon, Roxana Willigs, additional, Yañez, Anahi, additional, Baines, Stuart, additional, Bowler, Simon, additional, Bremner, Peter, additional, Bull, Sheetal, additional, Carroll, Patrick, additional, Chaalan, Mariam, additional, Farah, Claude, additional, Hammerschlag, Gary, additional, Hancock, Kerry, additional, Harrington, Zinta, additional, Katsoulotos, Gregory, additional, Kim, Joshua, additional, Langton, David, additional, Lee, Donald, additional, Peters, Matthew, additional, Prassad, Lakshman, additional, Sajkov, Dimitar, additional, Santiago, Francis, additional, Simpson, Frederick Graham, additional, Tai, Sze, additional, Thomas, Paul, additional, Wark, Peter, additional, Cançado, José Eduardo Delfini, additional, Cunha, Thúlio, additional, Lima, Marina, additional, Cardoso, Alexandre Pinto, additional, FitzGerald, J. Mark, additional, Anees, Syed, additional, Bertley, John, additional, Bell, Alan, additional, Cheema, Amarjit, additional, Chouinard, Guy, additional, Csanadi, Michael, additional, Dhar, Anil, additional, Dhillon, Ripple, additional, Kanawaty, David, additional, Kelly, Allan, additional, Killorn, William, additional, Landry, Daniel, additional, Luton, Robert, additional, Mandhane, Piushkumar, additional, Pek, Bonavuth, additional, Petrella, Robert, additional, Stollery, Daniel, additional, Wang, Chen, additional, Chen, Meihua, additional, Chen, Yan, additional, Gu, Wei, additional, Christopher Hui, Kim Ming, additional, Li, Manxiang, additional, Li, Shiyue, additional, Lijun, Ma, additional, Qin, Guangyue, additional, Song, Weidong, additional, Tan, Wei, additional, Tang, Yijun, additional, Wang, Tan, additional, Wen, Fuqiang, additional, Wu, Feng, additional, Xiang, PingChao, additional, Xiao, Zuke, additional, Xiong, Shengdao, additional, Yang, Jinghua, additional, Yang, Jingping, additional, Zhang, Caiqing, additional, Zhang, Min, additional, Zhang, Ping, additional, Zhang, Wei, additional, Zheng, Xiaohe, additional, Zhu, Dan, additional, Bueno, Carlos Matiz, additional, Grimaldos, Fabio Bolivar, additional, Arboleda, Alejandra Cañas, additional, de Salazar, Dora Molina, additional, Bendstrup, Elisabeth, additional, Hilberg, Ole, additional, Kjellerup, Carsten, additional, Raherison, Chantal, additional, Bonniaud, Philippe, additional, Brun, Olivier, additional, Chouaid, Christos, additional, Couturaud, Francis, additional, de Blic, Jacques, additional, Debieuvre, Didier, additional, Delsart, Dominique, additional, Demaegdt, Axelle, additional, Demoly, Pascal, additional, Deschildre, Antoine, additional, Egron, Carole, additional, Falchero, Lionel, additional, Goupil, François, additional, Kessler, Romain, additional, Le Roux, Pascal, additional, Mabire, Pascal, additional, Mahay, Guillaume, additional, Martinez, Stéphanie, additional, Melloni, Boris, additional, Moreau, Laurent, additional, Riviere, Emilie, additional, Roux-Claudé, Pauline, additional, Soulier, Michel, additional, Vignal, Guillaume, additional, Yaici, Azzedine, additional, Bals, Robert, additional, Aries, Sven Philip, additional, Beck, Ekkehard, additional, Deimling, Andreas, additional, Feimer, Jan, additional, Grimm-Sachs, Vera, additional, Groth, Gesine, additional, Herth, Felix, additional, Hoheisel, Gerhard, additional, Kanniess, Frank, additional, Lienert, Thomas, additional, Mronga, Silke, additional, Reinhardt, Jörg, additional, Schlenska, Christian, additional, Stolpe, Christoph, additional, Teber, Ishak, additional, Timmermann, Hartmut, additional, Ulrich, Thomas, additional, Velling, Peter, additional, Wehgartner-Winkler, Sabina, additional, Welling, Juergen, additional, Winkelmann, Ernst-Joachim, additional, Barbetta, Carlo, additional, Braido, Fulvio, additional, Cardaci, Vittorio, additional, Clini, Enrico Maria, additional, Costantino, Maria Teresa, additional, Cuttitta, Giuseppina, additional, di Gioacchino, Mario, additional, Fois, Alessandro, additional, Foschino-Barbaro, Maria Pia, additional, Gammeri, Enrico, additional, Inchingolo, Riccardo, additional, Lavorini, Federico, additional, Molino, Antonio, additional, Nucera, Eleonora, additional, Patella, Vincenzo, additional, Pesci, Alberto, additional, Ricciardolo, Fabio, additional, Rogliani, Paola, additional, Sarzani, Riccardo, additional, Vancheri, Carlo, additional, Vincenti, Rigoletta, additional, Endo, Takeo, additional, Fujita, Masaki, additional, Hara, Yu, additional, Horiguchi, Takahiko, additional, Hosoi, Keita, additional, Ide, Yumiko, additional, Inomata, Minehiko, additional, Inoue, Koji, additional, Inoue, Sumito, additional, Kato, Motokazu, additional, Kawasaki, Masayuki, additional, Kawayama, Tomotaka, additional, Kita, Toshiyuki, additional, Kobayashi, Kanako, additional, Koto, Hiroshi, additional, Nishi, Koichi, additional, Saito, Junpei, additional, Shimizu, Yasuo, additional, Shirai, Toshihiro, additional, Sugihara, Naruhiko, additional, Takahashi, Ken-ichi, additional, Tashimo, Hiroyuki, additional, Tomii, Keisuke, additional, Yamada, Takashi, additional, Yanai, Masaru, additional, Rendon, Adrian, additional, Cerino Javier, Ruth, additional, Domínguez Peregrina, Alfredo, additional, Fernández Corzo, Marco, additional, Montano Gonzalez, Efraín, additional, Ramírez-Venegas, Alejandra, additional, Boersma, Willem, additional, Djamin, R.S., additional, Eijsvogel, Michiel, additional, Franssen, Frits, additional, Goosens, Martijn, additional, Graat-Verboom, Lidwien, additional, Veen, Johannes in 't, additional, Janssen, Rob, additional, Kuppens, Kim, additional, van de Ven, Mario, additional, Bakke, Per, additional, Brunstad, Ole Petter, additional, Einvik, Gunnar, additional, Høines, Kristian Jong, additional, Khusrawi, Alamdar, additional, Oien, Torbjorn, additional, Yoon, Ho Joo, additional, Chang, Yoon-Seok, additional, Cho, Young Joo, additional, Hwang, Yong Il, additional, Kim, Woo Jin, additional, Koh, Young-Il, additional, Lee, Byung-Jae, additional, Lee, Kwan-Ho, additional, Lee, Sang-Pyo, additional, Lee, Yong Chul, additional, Lim, Seong Yong, additional, Min, Kyung Hun, additional, Oh, Yeon-Mok, additional, Park, Choon-Sik, additional, Park, Hae-Sim, additional, Park, Heung-Woo, additional, Rhee, Chin Kook, additional, Yoon, Hyoung-Kyu, additional, García-Navarro, Alvar Agustí, additional, Andújar, Rubén, additional, Anoro, Laura, additional, Buendía García, María, additional, Mozo, Paloma Campo, additional, Campos, Sergio, additional, Casas Maldonado, Francisco, additional, Castilla Martínez, Manuel, additional, Cisneros Serrano, Carolina, additional, Comeche Casanova, Lorena, additional, Corbacho, Dolores, additional, Campo Matías, Felix Del, additional, Echave-Sustaeta, Jose, additional, Corral, Gloria Francisco, additional, Gamboa Setién, Pedro, additional, García Clemente, Marta, additional, Núñez, Ignacio García, additional, García Robaina, Jose, additional, García Salmones, Mercedes, additional, Marín Trigo, Jose Maria, additional, Fernandez, Marta Nuñez, additional, Palomo, Sara Nuñez, additional, Pérez de Llano, Luis, additional, Pueyo Bastida, Ana, additional, Rañó, Ana, additional, Rodríguez González-Moro, José, additional, Reig, Albert Roger, additional, Velasco Garrido, José, additional, Curiac, Dan, additional, Lif-Tiberg, Cornelia, additional, Luts, Anders, additional, Råhlen, Lennart, additional, Rustscheff, Stefan, additional, Adams, Frances, additional, Bradman, Drew, additional, Broughton, Emma, additional, Cosgrove, John, additional, Flood-Page, Patrick, additional, Fuller, Elizabeth, additional, Hartley, David, additional, Hattotuwa, Keith, additional, Jones, Gareth, additional, Lewis, Keir, additional, McGarvey, Lorcan, additional, Morice, Alyn, additional, Pandya, Preeti, additional, Patel, Manish, additional, Roy, Kay, additional, Sathyamurthy, Ramamurthy, additional, Thiagarajan, Swaminathan, additional, Turner, Alice, additional, Wedzicha, Wisia, additional, Wilkinson, Tom, additional, Wilson, Pete, additional, Al-Asadi, Lo’Ay, additional, Anholm, James, additional, Averill, Francis, additional, Bansal, Sandeep, additional, Baptist, Alan, additional, Campbell, Colin, additional, Campos, Michael A., additional, Crook, Gretchen, additional, DeLeon, Samuel, additional, Eid, Alain, additional, Epstein, Ellen, additional, Fritz, Stephen, additional, Harris, Hoadley, additional, Hewitt, Mitzie, additional, Holguin, Fernando, additional, Hudes, Golda, additional, Jackson, Richard, additional, Kaufman, Alan, additional, Kaufman, David, additional, Klapholz, Ari, additional, Krishna, Harshavardhan, additional, Lee, Daria, additional, Lin, Robert, additional, Maselli-Caceres, Diego, additional, Mehta, Vinay, additional, Moy, James N., additional, Nwokoro, Ugo, additional, Parikh, Purvi, additional, Parikh, Sudhir, additional, Perrino, Frank, additional, Ruhlmann, James, additional, Sassoon, Catherine, additional, Settipane, Russell A., additional, Sousa, Daniel, additional, Sriram, Peruvemba, additional, and Wachs, Richard, additional

Published
2023
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37. The reality of managing asthma in sub-Saharan Africa – Priorities and strategies for improving care

Author

Mortimer, Kevin, Masekela, Refiloe, Ozoh, Obianuju B, Bateman, Eric Donn, Nantanda, Rebecca, Yorgancıoğlu, Arzu A., Chakaya, Jeremiah, and Reddel, Helen K.

Subjects
Asthma, Low-middle-income country, Asthma guideline, Global initiative for asthma, Asthma medication
Abstract

Asthma is the most common non-communicable disease in children and remains one of the most common throughout the life course. The great majority of the burden of this disease is seen in low-income and middle-income countries (LMICs), which have disproportionately high asthma-related mortality relative to asthma prevalence. This is particularly true for many countries in sub-Saharan Africa. Although inhaled asthma treatments (particularly those containing inhaled corticosteroids) markedly reduce asthma morbidity and mortality, a substantial proportion of the children, adolescents, and adults with asthma in LMICs do not get to benefit from these, due to poor availability and affordability. In this review, we consider the reality faced by clinicians managing asthma in the primary and secondary care in sub-Saharan Africa and suggest how we might go about making diagnosis and treatment decisions in a range of resource-constrained scenarios. We also provide recommendations for research and policy, to help bridge the gap between current practice in sub-Saharan Africa and Global Initiative for Asthma (GINA) recommended diagnostic processes and treatment for children, adolescents, and adults with asthma.

Published
2022

40. Symptom Burden, Health Status, and Productivity in Patients with Uncontrolled and Controlled Severe Asthma in NOVELTY

Author

Ding,Bo, Chen,Stephanie, Srivastava,Divyansh, Quinton,Anna, Cook,William, Papi,Alberto, and Reddel,Helen K

Subjects
Journal of Asthma and Allergy
Abstract

Bo Ding,1 Stephanie Chen,2 Divyansh Srivastava,3 Anna Quinton,4 William Cook,2 Alberto Papi,5 Helen K Reddel,6on behalf of the NOVELTY Scientific Community and the NOVELTY study investigators1BioPharmaceuticals Medical, AstraZeneca, Gothenburg, Sweden; 2BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, MD, USA; 3ZS Associates, Pune, India; 4BioPharmaceuticals Business Unit, AstraZeneca, Cambridge, UK; 5Department of Translational Medicine, Università di Ferrara, Ferrara, Italy; 6The Woolcock Institute of Medical Research and the University of Sydney, Sydney, NSW, AustraliaCorrespondence: Bo Ding, AstraZeneca, Pepparedsleden 1, Mölndal, SE 431 83, Gothenburg, Sweden, Tel +46 31 776 2406, Email bo.ding@astrazeneca.comBackground: Few studies have quantified symptom burden, health status, and productivity in patients with uncontrolled and controlled severe asthma. Up-to-date, real-world, global evidence is needed.Objective: To quantify symptom burden, health status, and productivity in patients with uncontrolled and controlled severe asthma using baseline data from the NOVEL observational longiTudinal studY (NOVELTY; NCT02760329).Methods: NOVELTY included patients aged ≥ 18 years (or ≥ 12 years in some countries) from primary care and specialist centres in 19 countries, with a physician-assigned diagnosis of asthma, asthma+chronic obstructive pulmonary disease (COPD), or COPD. Disease severity was physician-assessed. Uncontrolled severe asthma was defined by an Asthma Control Test (ACT) score < 20 and/or severe physician-reported exacerbations in the previous year; controlled severe asthma required an ACT score ≥ 20 and no severe exacerbations. Assessment of symptom burden included Respiratory Symptoms Questionnaire (RSQ) and ACT score. Assessment of health status included St George’s Respiratory Questionnaire (SGRQ), EuroQoL 5 Dimensions 5 Levels Health Questionnaire (EQ-5D-5L) index value, and EQ-5D-5L Visual Analog Score (EQ-VAS). Assessment of productivity loss included absenteeism, presenteeism, overall work impairment, and activity impairment.Results: Of 1652 patients with severe asthma, asthma was uncontrolled in 1078 (65.3%; mean age 52.6 years, 65.8% female) and controlled in 315 (19.1%; mean age 55.2 years, 56.5% female). With uncontrolled versus controlled severe asthma, symptom burden was higher (mean RSQ score 7.7 vs 2.5), health status more impaired (mean SGRQ total score 47.5 vs 22.4; mean EQ-5D-5L index value 0.68 vs 0.90; mean EQ-VAS score 64.1 vs 78.1), and productivity lower (presenteeism 29.3% vs 10.5%).Conclusion: Our findings highlight the symptom burden of uncontrolled severe asthma compared with controlled severe asthma and its impact on patient health status and productivity, and support the need for interventions to improve control of severe asthma.Graphical Abstract: Keywords: asthma control, health status, productivity, symptom burden, symptom control, uncontrolled severe asthma

Published
2023

41. A Call for the United States to Accelerate the Implementation of Reliever Combination Inhaled Corticosteroid–Formoterol Inhalers in Asthma

Author

Krings, James G., primary, Gerald, Joe K., additional, Blake, Kathryn V., additional, Krishnan, Jerry A., additional, Reddel, Helen K., additional, Bacharier, Leonard B., additional, Dixon, Anne E., additional, Sumino, Kaharu, additional, Gerald, Lynn B., additional, Brownson, Ross C., additional, Persell, Stephen D., additional, Clemens, Conrad J., additional, Hiller, Katherine M., additional, Castro, Mario, additional, and Martinez, Fernando D., additional

Published
2023
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42. Budesonide/formoterol maintenance and reliever therapy versus fluticasone/salmeterol fixed-dose treatment in patients with COPD

Author

Muiser, Susan, primary, Imkamp, Kai, additional, Seigers, Dianne, additional, Halbersma, Nynke J, additional, Vonk, Judith M, additional, Luijk, Bart H D, additional, Braunstahl, Gert-Jan, additional, van den Berg, Jan-Willem, additional, Kroesen, Bart-Jan, additional, Kocks, Janwillem W H, additional, Heijink, Irene H, additional, Reddel, Helen K, additional, Kerstjens, Huib A M, additional, and van den Berge, Maarten, additional

Published
2023
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43. Respiratory Symptoms, Disease Burden, and Quality of Life in Australian Adults According to GOLD Spirometry Grades: Data from the BOLD Australia Study

Author

Zhou,Yijun, Ampon,Maria, Abramson,Michael, James,Alan, Maguire,Graeme P, Wood-Baker,Richard, Johns,David, Marks,Guy B, Reddel,Helen K, Toelle,Brett G, Zhou,Yijun, Ampon,Maria, Abramson,Michael, James,Alan, Maguire,Graeme P, Wood-Baker,Richard, Johns,David, Marks,Guy B, Reddel,Helen K, and Toelle,Brett G

Abstract

Yijun Zhou,1 Maria R Ampon,2 Michael J Abramson,3 Alan L James,4 Graeme P Maguire,5 Richard Wood-Baker,6 David P Johns,6 Guy B Marks,1,7 Helen K Reddel,2,8,9 Brett G Toelle1,8,9 1The Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia; 2Australian Centre for Airways Disease Monitoring, The Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia; 3School of Public Health & Preventive Medicine, Monash University, Melbourne, VIC, Australia; 4Sir Charles Gairdner Hospital, Perth, WA, Australia; 5Curtin Medical School, Curtin University, Perth, WA, Australia; 6Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; 7South Western Sydney Clinical School, University of New South Wales, Sydney, NSW, Australia; 8Faculty of Medicine, Health and Human Science, Macquarie University, Sydney, NSW, Australia; 9Sydney Local Health District, Sydney, NSW, AustraliaCorrespondence: Brett G Toelle, Woolcock Institute of Medical Research, 431 Glebe Point Road, Glebe, NSW, 2037, Australia, Email brett.toelle@woolcock.org.auPurpose: Population data on the burden of chronic obstructive pulmonary disease (COPD) are often based on patient-reported diagnoses of COPD, emphysema or chronic bronchitis, without spirometry. We aimed to investigate the relationship between health burden, quality of life and severity of airway obstruction in Australian adults aged ≥ 40 years.Methods: We used data from the BOLD Australia study, which included randomly selected adults aged ≥ 40 years from six study sites to reflect the sociodemographic and geographic diversity of the Australian population (n = 3522). Participants with post-bronchodilator airflow limitation (ratio of forced expiratory volume in 1 second FEV1 to forced vital capacity < 0.7) were grouped by GOLD spirometry grades 1– 4. Quality of life was assessed with Short Form 12 (SF-12) Health Survey Questionnaire. Health bu

Published
2023

44. Budesonide/formoterol maintenance and reliever therapy versus fluticasone/salmeterol fixed-dose treatment in patients with COPD

Author

Longziekten, Infection & Immunity, Muiser, Susan, Imkamp, Kai, Seigers, Dianne, Halbersma, Nynke J., Vonk, Judith M., Luijk, Bart H.D., Braunstahl, Gert Jan, Van Den Berg, Jan Willem, Kroesen, Bart Jan, Kocks, Janwillem W.H., Heijink, Irene H., Reddel, Helen K., Kerstjens, Huib A.M., Van Den Berge, Maarten, Longziekten, Infection & Immunity, Muiser, Susan, Imkamp, Kai, Seigers, Dianne, Halbersma, Nynke J., Vonk, Judith M., Luijk, Bart H.D., Braunstahl, Gert Jan, Van Den Berg, Jan Willem, Kroesen, Bart Jan, Kocks, Janwillem W.H., Heijink, Irene H., Reddel, Helen K., Kerstjens, Huib A.M., and Van Den Berge, Maarten

Published
2023

47. Diagnostic performance of a machine-learning algorithm (Asthma/COPD Differentiation Classification; AC/DC) tool versus primary care physicians and pulmonologists in asthma, COPD and ACO

Author

Kocks, Janwillem W.H., primary, Cao, Hui, additional, Holzhauer, Björn, additional, Kaplan, Alan, additional, FitzGerald, J. Mark, additional, Kostikas, Konstantinos, additional, Price, David, additional, Reddel, Helen K., additional, Tsiligianni, Ioanna, additional, Vogelmeier, Claus F., additional, Bostel, Sebastien, additional, and Mastoridis, Paul, additional

Published
2023
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