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29 results on '"Redchenko, Irina"'

1. Phenotype and Reactivity of Lymphocytes Expanded from Benign Prostate Hyperplasic Tissues and Prostate Cancer

Author

Ahmed, Ritaparna, primary, Lozano, Leyder Elena, additional, Anastasio, Amandine, additional, Lofek, Sebastien, additional, Mastelic-Gavillet, Beatris, additional, Navarro Rodrigo, Blanca, additional, Nguyen, Sylvain, additional, Dartiguenave, Florence, additional, Rodrigues-Dias, Sonia-Cristina, additional, Cesson, Valérie, additional, Valério, Massimo, additional, Roth, Beat, additional, Kandalaft, Lana Elias, additional, Redchenko, Irina, additional, Hill, Adrian Vivian Sinton, additional, Harari, Alexandre, additional, Romero, Pedro, additional, Derré, Laurent, additional, and Viganó, Selena, additional

Published
2023
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3. Heterologous prime-boost vaccination targeting MAGE-type antigens promotes tumor T-cell infiltration and improves checkpoint blockade therapy

Author

McAuliffe, James, primary, Chan, Hok Fung, additional, Noblecourt, Laurine, additional, Ramirez-Valdez, Ramiro Andrei, additional, Pereira-Almeida, Vinnycius, additional, Zhou, Yaxuan, additional, Pollock, Emily, additional, Cappuccini, Federica, additional, Redchenko, Irina, additional, Hill, Adrian VS, additional, Leung, Carol Sze Ki, additional, and Van den Eynde, Benoit J, additional

Published
2021
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5. Heterologous prime-boost vaccination targeting MAGE-type antigens promotes tumor T-cell infiltration and improves checkpoint blockade therapy.

Author

UCL - SSS/DDUV/GECE - Génétique cellulaire, McAuliffe, James, Chan, Hok Fung, Noblecourt, Laurine, Ramirez-Valdez, Ramiro Andrei, Pereira-Almeida, Vinnycius, Zhou, Yaxuan, Pollock, Emily, Cappuccini, Federica, Redchenko, Irina, Hill, Adrian Vs, Leung, Carol Sze Ki, Van den Eynde, Benoît, UCL - SSS/DDUV/GECE - Génétique cellulaire, McAuliffe, James, Chan, Hok Fung, Noblecourt, Laurine, Ramirez-Valdez, Ramiro Andrei, Pereira-Almeida, Vinnycius, Zhou, Yaxuan, Pollock, Emily, Cappuccini, Federica, Redchenko, Irina, Hill, Adrian Vs, Leung, Carol Sze Ki, and Van den Eynde, Benoît

Abstract

The clinical benefit of immune checkpoint blockade (ICB) therapy is often limited by the lack of pre-existing CD8 T cells infiltrating the tumor. In principle, CD8 T-cell infiltration could be promoted by therapeutic vaccination. However, this remains challenging given the paucity of vaccine platforms able to induce the strong cytotoxic CD8 T-cell response required to reject tumors. A therapeutic cancer vaccine that induces a robust cytotoxic CD8 T-cell response against shared tumor antigens and can be combined with ICB could improve the outcome of cancer immunotherapy. Here, we developed a heterologous prime-boost vaccine based on a chimpanzee adenovirus (ChAdOx1) and a modified vaccinia Ankara (MVA) encoding MAGE-type antigens, which are tumor-specific shared antigens expressed in different tumor types. The mouse MAGE-type antigen P1A was used as a surrogate to study the efficacy of the vaccine in combination with ICB in murine tumor models expressing the P1A antigen. To characterize the vaccine-induced immune response, we performed flow cytometry and transcriptomic analyses. The ChAdOx1/MVA vaccine displayed strong immunogenicity with potent induction of CD8 T cells. When combined with anti-Programmed Cell Death Protein 1 (PD-1), the vaccine induced superior tumor clearance and survival in murine tumor models expressing P1A compared with anti-PD-1 alone. Remarkably, ChAdOx1/MVA P1A vaccination promoted CD8 T-cell infiltration in the tumors, and drove inflammation in the tumor microenvironment, turning 'cold' tumors into 'hot' tumors. Single-cell transcriptomic analysis of the P1A-specific CD8 T cells revealed an expanded population of stem-like T cells in the spleen after the combination treatment as compared with vaccine alone, and a reduced PD-1 expression in the tumor CD8 T cells. These findings highlight the synergistic potency of ChAdOx1/MVA MAGE vaccines combined with anti-PD-1 for cancer therapy, and establish the foundation for clinical translation of thi

Published
2021

8. Safety and immunogenicity of novel 5T4 viral vectored vaccination regimens in early stage prostate cancer: a phase I clinical trial

Author

Cappuccini, Federica, primary, Bryant, Richard, additional, Pollock, Emily, additional, Carter, Lucy, additional, Verrill, Clare, additional, Hollidge, Julianne, additional, Poulton, Ian, additional, Baker, Megan, additional, Mitton, Celia, additional, Baines, Andrea, additional, Meier, Armin, additional, Schmidt, Guenter, additional, Harrop, Richard, additional, Protheroe, Andrew, additional, MacPherson, Ruth, additional, Kennish, Steven, additional, Morgan, Susan, additional, Vigano, Selena, additional, Romero, Pedro J, additional, Evans, Thomas, additional, Catto, James, additional, Hamdy, Freddie, additional, Hill, Adrian V S, additional, and Redchenko, Irina, additional

Published
2020
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9. Phase I/II open label nonrandomized safety and efficacy study of the viral vectored ChAdOx1-MVA 5T4 immunotherapy in combination with PD-1 checkpoint blockade in intermediate-risk localized or locally advanced prostate cancer and advanced metastatic prostate cancer.

Author

Tuthill, Mark, primary, Cappuccini, Federica, additional, Bryant, Richard John, additional, Poulton, Ian, additional, Pollock, Emily, additional, Carter, Lucy, additional, Verrill, Clare, additional, Meier, Armin, additional, Schmidt, Günter, additional, Catto, James WF, additional, Evans, Tom, additional, Gillessen, Silke, additional, Protheroe, Andrew, additional, Hamdy, Freddie, additional, Hill, Adrian V.S., additional, and Redchenko, Irina, additional

Published
2020
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10. Safety and exceptional immunogenicity of novel 5T4 viral vectored vaccination regimes in early stage prostate cancer: a phase I clinical trial

Author

Cappuccini, Federica, primary, Bryant, Richard, additional, Pollock, Emily, additional, Carter, Lucy, additional, Verrill, Clare, additional, Hollidge, Julianne, additional, Poulton, Ian, additional, Baker, Megan, additional, Mitton, Celia, additional, Baines, Andrea, additional, Meier, Armin, additional, Schmidt, Guenter, additional, Harrop, Richard, additional, Protheroe, Andrew, additional, MacPherson, Ruth, additional, Kennish, Steven, additional, Morgan, Susan, additional, Vigano, Selena, additional, Romero, Pedro, additional, Evans, Thomas, additional, Catto, James W.F., additional, Hamdy, Freddie, additional, Hill, Adrian V.S., additional, and Redchenko, Irina, additional

Published
2020
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13. VANCE: First-in-human phase I study of a novel ChAdOx1-MVA 5T4 vaccine in low and intermediate risk prostate cancer.

Author

Redchenko, Irina, primary, Cappuccini, Federica, additional, Pollock, Emily, additional, Bryant, Richard John, additional, Carter, Lucy, additional, Verrill, Clare, additional, Hollidge, Julianne, additional, Goodwin, Louise, additional, Harrop, Richard, additional, Romero, Pedro Julio, additional, Vigano, Selena, additional, Evans, Tom, additional, Catto, James, additional, Hamdy, Freddie, additional, and Hill, Adrian V.S., additional

Published
2018
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14. 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two

Author

Ager, Casey, Reilley, Matthew, Nicholas, Courtney, Bartkowiak, Todd, Jaiswal, Ashvin, Curran, Michael, Albershardt, Tina C., Bajaj, Anshika, Archer, Jacob F., Reeves, Rebecca S., Ngo, Lisa Y., Berglund, Peter, ter Meulen, Jan, Denis, Caroline, Ghadially, Hormas, Arnoux, Thomas, Chanuc, Fabien, Fuseri, Nicolas, Wilkinson, Robert W., Wagtmann, Nicolai, Morel, Yannis, Andre, Pascale, Atkins, Michael B., Carlino, Matteo S., Ribas, Antoni, Thompson, John A., Choueiri, Toni K., Hodi, F. Stephen, Hwu, Wen-Jen, McDermott, David F., Atkinson, Victoria, Cebon, Jonathan S., Fitzharris, Bernie, Jameson, Michael B., McNeil, Catriona, Hill, Andrew G., Mangin, Eric, Ahamadi, Malidi, van Vugt, Marianne, van Zutphen, Mariëlle, Ibrahim, Nageatte, Long, Georgina V., Gartrell, Robyn, Blake, Zoe, Simoes, Ines, Fu, Yichun, Saito, Takuro, Qian, Yingzhi, Lu, Yan, Saenger, Yvonne M., Budhu, Sadna, De Henau, Olivier, Zappasodi, Roberta, Schlunegger, Kyle, Freimark, Bruce, Hutchins, Jeff, Barker, Christopher A., Wolchok, Jedd D., Merghoub, Taha, Burova, Elena, Allbritton, Omaira, Hong, Peter, Dai, Jie, Pei, Jerry, Liu, Matt, Kantrowitz, Joel, Lai, Venus, Poueymirou, William, MacDonald, Douglas, Ioffe, Ella, Mohrs, Markus, Olson, William, Thurston, Gavin, Capasso, Cristian, Frascaro, Federica, Carpi, Sara, Tähtinen, Siri, Feola, Sara, Fusciello, Manlio, Peltonen, Karita, Martins, Beatriz, Sjöberg, Madeleine, Pesonen, Sari, Ranki, Tuuli, Kyruk, Lukasz, Ylösmäki, Erkko, Cerullo, Vincenzo, Cerignoli, Fabio, Xi, Biao, Guenther, Garret, Yu, Naichen, Muir, Lincoln, Zhao, Leyna, Abassi, Yama, Cervera-Carrascón, Víctor, Siurala, Mikko, Santos, João, Havunen, Riikka, Parviainen, Suvi, Hemminki, Akseli, Dalgleish, Angus, Mudan, Satvinder, DeBenedette, Mark, Plachco, Ana, Gamble, Alicia, Grogan, Elizabeth W., Krisko, John, Tcherepanova, Irina, Nicolette, Charles, Dhupkar, Pooja, Yu, Ling, Kleinerman, Eugenie S., Gordon, Nancy, Grenga, Italia, Lepone, Lauren, Gameiro, Sofia, Knudson, Karin M., Fantini, Massimo, Tsang, Kwong, Hodge, James, Donahue, Renee, Schlom, Jeffrey, Evans, Elizabeth, Bussler, Holm, Mallow, Crystal, Reilly, Christine, Torno, Sebold, Scrivens, Maria, Foster, Cathie, Howell, Alan, Balch, Leslie, Knapp, Alyssa, Leonard, John E., Paris, Mark, Fisher, Terry, Hu-Lieskovan, Siwen, Smith, Ernest, Zauderer, Maurice, Fogler, William, Franklin, Marilyn, Thayer, Matt, Saims, Dan, Magnani, John L., Gong, Jian, Gray, Michael, Fromm, George, de Silva, Suresh, Giffin, Louise, Xu, Xin, Rose, Jason, Schreiber, Taylor H., Gameiro, Sofia R., Clavijo, Paul E., Allen, Clint T., Hodge, James W., Tsang, Kwong Y., Grogan, Jane, Manieri, Nicholas, Chiang, Eugene, Caplazi, Patrick, Yadav, Mahesh, Hagner, Patrick, Chiu, Hsiling, Waldman, Michelle, Klippel, Anke, Thakurta, Anjan, Pourdehnad, Michael, Gandhi, Anita, Henrich, Ian, Quick, Laura, Young, Rob, Chou, Margaret, Hotson, Andrew, Willingham, Stephen, Ho, Po, Choy, Carmen, Laport, Ginna, McCaffery, Ian, Miller, Richard, Tipton, Kimberly A., Wong, Kenneth R., Singson, Victoria, Wong, Chihunt, Chan, Chanty, Huang, Yuanhiu, Liu, Shouchun, Richardson, Jennifer H., Kavanaugh, W. Michael, West, James, Irving, Bryan A., Jaini, Ritika, Loya, Matthew, Eng, Charis, Johnson, Melissa L., Adjei, Alex A., Opyrchal, Mateusz, Ramalingam, Suresh, Janne, Pasi A., Dominguez, George, Gabrilovich, Dmitry, de Leon, Laura, Hasapidis, Jeannette, Diede, Scott J., Ordentlich, Peter, Cruickshank, Scott, Meyers, Michael L., Hellmann, Matthew D., Kalinski, Pawel, Zureikat, Amer, Edwards, Robert, Muthuswamy, Ravi, Obermajer, Nataša, Urban, Julie, Butterfield, Lisa H., Gooding, William, Zeh, Herbert, Bartlett, David, Zubkova, Olga, Agapova, Larissa, Kapralova, Marina, Krasovskaia, Liudmila, Ovsepyan, Armen, Lykov, Maxim, Eremeev, Artem, Bokovanov, Vladimir, Grigoryeva, Olga, Karpov, Andrey, Ruchko, Sergey, Shuster, Alexandr, Khalil, Danny N., Campesato, Luis Felipe, Li, Yanyun, Lazorchak, Adam S., Patterson, Troy D., Ding, Yueyun, Sasikumar, Pottayil, Sudarshan, Naremaddepalli, Gowda, Nagaraj, Ramachandra, Raghuveer, Samiulla, Dodheri, Giri, Sanjeev, Eswarappa, Rajesh, Ramachandra, Murali, Tuck, David, Wyant, Timothy, Leshem, Jasmin, Liu, Xiu-fen, Bera, Tapan, Terabe, Masaki, Bossenmaier, Birgit, Niederfellner, Gerhard, Reiter, Yoram, Pastan, Ira, Xia, Leiming, Xia, Yang, Hu, Yangyang, Wang, Yi, Bao, Yangyi, Dai, Fu, Huang, Shiang, Hurt, Elaine, Hollingsworth, Robert E., Lum, Lawrence G., Chang, Alfred E., Wicha, Max S., Li, Qiao, Mace, Thomas, Makhijani, Neil, Talbert, Erin, Young, Gregory, Guttridge, Denis, Conwell, Darwin, Lesinski, Gregory B., Gonzales, Rodney JM Macedo, Huffman, Austin P., Wang, Ximi K., Reshef, Ran, MacKinnon, Andy, Chen, Jason, Gross, Matt, Marguier, Gisele, Shwonek, Peter, Sotirovska, Natalija, Steggerda, Susanne, Parlati, Francesco, Makkouk, Amani, Bennett, Mark K., Emberley, Ethan, Huang, Tony, Li, Weiqun, Neou, Silinda, Pan, Alison, Zhang, Jing, Zhang, Winter, Marshall, Netonia, Marron, Thomas U., Agudo, Judith, Brown, Brian, Brody, Joshua, McQuinn, Christopher, Farren, Matthew, Komar, Hannah, Shakya, Reena, Ludwug, Thomas, Morillon, Y. Maurice, Hammond, Scott A., Greiner, John W., Nath, Pulak R., Schwartz, Anthony L., Maric, Dragan, Roberts, David D., Naing, Aung, Papadopoulos, Kyriakos P., Autio, Karen A., Wong, Deborah J., Patel, Manish, Falchook, Gerald, Pant, Shubham, Ott, Patrick A., Whiteside, Melinda, Patnaik, Amita, Mumm, John, Janku, Filip, Chan, Ivan, Bauer, Todd, Colen, Rivka, VanVlasselaer, Peter, Brown, Gail L., Tannir, Nizar M., Oft, Martin, Infante, Jeffrey, Lipson, Evan, Gopal, Ajay, Neelapu, Sattva S., Armand, Philippe, Spurgeon, Stephen, Leonard, John P., Sanborn, Rachel E., Melero, Ignacio, Gajewski, Thomas F., Maurer, Matthew, Perna, Serena, Gutierrez, Andres A., Clynes, Raphael, Mitra, Priyam, Suryawanshi, Satyendra, Gladstone, Douglas, Callahan, Margaret K., Crooks, James, Brown, Sheila, Gauthier, Audrey, de Boisferon, Marc Hillairet, MacDonald, Andrew, Brunet, Laura Rosa, Rothwell, William T., Bell, Peter, Wilson, James M., Sato-Kaneko, Fumi, Yao, Shiyin, Zhang, Shannon S., Carson, Dennis A., Guiducci, Cristina, Coffman, Robert L., Kitaura, Kazutaka, Matsutani, Takaji, Suzuki, Ryuji, Hayashi, Tomoko, Cohen, Ezra E. W., Schaer, David, Li, Yanxia, Dobkin, Julie, Amatulli, Michael, Hall, Gerald, Doman, Thompson, Manro, Jason, Dorsey, Frank Charles, Sams, Lillian, Holmgaard, Rikke, Persaud, Krishnadatt, Ludwig, Dale, Surguladze, David, Kauh, John S., Novosiadly, Ruslan, Kalos, Michael, Driscoll, Kyla, Pandha, Hardev, Ralph, Christy, Harrington, Kevin, Curti, Brendan, Akerley, Wallace, Gupta, Sumati, Melcher, Alan, Mansfield, David, Kaufman, David R., Schmidt, Emmett, Grose, Mark, Davies, Bronwyn, Karpathy, Roberta, Shafren, Darren, Shamalov, Katerina, Cohen, Cyrille, Sharma, Naveen, Allison, James, Shekarian, Tala, Valsesia-Wittmann, Sandrine, Caux, Christophe, Marabelle, Aurelien, Slomovitz, Brian M., Moore, Kathleen M., Youssoufian, Hagop, Posner, Marshall, Tewary, Poonam, Brooks, Alan D., Xu, Ya-Ming, Wijeratne, Kithsiri, Gunatilaka, Leslie A. A., Sayers, Thomas J., Vasilakos, John P., Alston, Tesha, Dovedi, Simon, Elvecrog, James, Grigsby, Iwen, Herbst, Ronald, Johnson, Karen, Moeckly, Craig, Mullins, Stefanie, Siebenaler, Kristen, SternJohn, Julius, Tilahun, Ashenafi, Tomai, Mark A., Vogel, Katharina, Vietsch, Eveline E., Wellstein, Anton, Wythes, Martin, Crosignani, Stefano, Tumang, Joseph, Alekar, Shilpa, Bingham, Patrick, Cauwenberghs, Sandra, Chaplin, Jenny, Dalvie, Deepak, Denies, Sofie, De Maeseneire, Coraline, Feng, JunLi, Frederix, Kim, Greasley, Samantha, Guo, Jie, Hardwick, James, Kaiser, Stephen, Jessen, Katti, Kindt, Erick, Letellier, Marie-Claire, Li, Wenlin, Maegley, Karen, Marillier, Reece, Miller, Nichol, Murray, Brion, Pirson, Romain, Preillon, Julie, Rabolli, Virginie, Ray, Chad, Ryan, Kevin, Scales, Stephanie, Srirangam, Jay, Solowiej, Jim, Stewart, Al, Streiner, Nicole, Torti, Vince, Tsaparikos, Konstantinos, Zheng, Xianxian, Driessens, Gregory, Gomes, Bruno, Kraus, Manfred, Xu, Chunxiao, Zhang, Yanping, Kradjian, Giorgio, Qin, Guozhong, Qi, Jin, Xu, Xiaomei, Marelli, Bo, Yu, Huakui, Guzman, Wilson, Tighe, Rober, Salazar, Rachel, Lo, Kin-Ming, English, Jessie, Radvanyi, Laszlo, Lan, Yan, Postow, Michael, Senbabaoglu, Yasin, Gasmi, Billel, Zhong, Hong, Liu, Cailian, Hirschhorhn-Cymerman, Daniel, Zha, Yuanyuan, Malnassy, Gregory, Fulton, Noreen, Park, Jae-Hyun, Stock, Wendy, Nakamura, Yusuke, Liu, Hongtao, Ju, Xiaoming, Kosoff, Rachelle, Ramos, Kimberly, Coder, Brandon, Petit, Robert, Princiotta, Michael, Perry, Kyle, Zou, Jun, Arina, Ainhoa, Fernandez, Christian, Zheng, Wenxin, Beckett, Michael A., Mauceri, Helena J., Fu, Yang-Xin, Weichselbaum, Ralph R., Lewis, Whitney, Han, Yanyan, Wu, Yeting, Yang, Chou, Huang, Jing, Wu, Dongyun, Li, Jin, Liang, Xiaoling, Zhou, Xiangjun, Hou, Jinlin, Hassan, Raffit, Jahan, Thierry, Antonia, Scott J., Kindler, Hedy L., Alley, Evan W., Honarmand, Somayeh, Liu, Weiqun, Leong, Meredith L., Whiting, Chan C., Nair, Nitya, Enstrom, Amanda, Lemmens, Edward E., Tsujikawa, Takahiro, Kumar, Sushil, Coussens, Lisa M., Murphy, Aimee L., Brockstedt, Dirk G., Koch, Sven D., Sebastian, Martin, Weiss, Christian, Früh, Martin, Pless, Miklos, Cathomas, Richard, Hilbe, Wolfgang, Pall, Georg, Wehler, Thomas, Alt, Jürgen, Bischoff, Helge, Geissler, Michael, Griesinger, Frank, Kollmeier, Jens, Papachristofilou, Alexandros, Doener, Fatma, Fotin-Mleczek, Mariola, Hipp, Madeleine, Hong, Henoch S., Kallen, Karl-Josef, Klinkhardt, Ute, Stosnach, Claudia, Scheel, Birgit, Schroeder, Andreas, Seibel, Tobias, Gnad-Vogt, Ulrike, Zippelius, Alfred, Park, Ha-Ram, Ahn, Yong-Oon, Kim, Tae Min, Kim, Soyeon, Kim, Seulki, Lee, Yu Soo, Keam, Bhumsuk, Kim, Dong-Wan, Heo, Dae Seog, Pilon-Thomas, Shari, Weber, Amy, Morse, Jennifer, Kodumudi, Krithika, Liu, Hao, Mullinax, John, Sarnaik, Amod A., Pike, Luke, Bang, Andrew, Balboni, Tracy, Taylor, Allison, Spektor, Alexander, Wilhite, Tyler, Krishnan, Monica, Cagney, Daniel, Alexander, Brian, Aizer, Ayal, Buchbinder, Elizabeth, Awad, Mark, Ghandi, Leena, Schoenfeld, Jonathan, Lessey-Morillon, Elizabeth, Ridnour, Lisa, Segal, Neil H., Sharma, Manish, Le, Dung T., Ferris, Robert L., Zelenetz, Andrew D., Levy, Ronald, Lossos, Izidore S., Jacobson, Caron, Ramchandren, Radhakrishnan, Godwin, John, Colevas, A. Dimitrios, Meier, Roland, Krishnan, Suba, Gu, Xuemin, Neely, Jaclyn, Timmerman, John, Vanpouille-Box, Claire I., Formenti, Silvia C., Demaria, Sandra, Wennerberg, Erik, Mediero, Aranzazu, Cronstein, Bruce N., Gustafson, Michael P., DiCostanzo, AriCeli, Wheatley, Courtney, Kim, Chul-Ho, Bornschlegl, Svetlana, Gastineau, Dennis A., Johnson, Bruce D., Dietz, Allan B., MacDonald, Cameron, Bucsek, Mark, Qiao, Guanxi, Hylander, Bonnie, Repasky, Elizabeth, Turbitt, William J., Xu, Yitong, Mastro, Andrea, Rogers, Connie J., Withers, Sita, Wang, Ziming, Khuat, Lam T., Dunai, Cordelia, Blazar, Bruce R., Longo, Dan, Rebhun, Robert, Grossenbacher, Steven K., Monjazeb, Arta, Murphy, William J., Rowlinson, Scott, Agnello, Giulia, Alters, Susan, Lowe, David, Scharping, Nicole, Menk, Ashley V., Whetstone, Ryan, Zeng, Xue, Delgoffe, Greg M., Santos, Patricia M., Shi, Jian, Delgoffe, Greg, Nagasaka, Misako, Sukari, Ammar, Byrne-Steele, Miranda, Pan, Wenjing, Hou, Xiaohong, Brown, Brittany, Eisenhower, Mary, Han, Jian, Collins, Natalie, Manguso, Robert, Pope, Hans, Shrestha, Yashaswi, Boehm, Jesse, Haining, W. Nicholas, Cron, Kyle R., Sivan, Ayelet, Aquino-Michaels, Keston, Orecchioni, Marco, Bedognetti, Davide, Hendrickx, Wouter, Fuoco, Claudia, Spada, Filomena, Sgarrella, Francesco, Cesareni, Gianni, Marincola, Francesco, Kostarelos, Kostas, Bianco, Alberto, Delogu, Lucia, Roelands, Jessica, Boughorbel, Sabri, Decock, Julie, Presnell, Scott, Wang, Ena, Marincola, Franco M., Kuppen, Peter, Ceccarelli, Michele, Rinchai, Darawan, Chaussabel, Damien, Miller, Lance, Nguyen, Andrew, Sanborn, J. Zachary, Vaske, Charles, Rabizadeh, Shahrooz, Niazi, Kayvan, Benz, Steven, Patel, Shashank, Restifo, Nicholas, White, James, Angiuoli, Sam, Sausen, Mark, Jones, Sian, Sevdali, Maria, Simmons, John, Velculescu, Victor, Diaz, Luis, Zhang, Theresa, Sims, Jennifer S., Barton, Sunjay M., Kadenhe-Chiweshe, Angela, Dela Cruz, Filemon, Turk, Andrew T., Mazzeo, Christopher F., Kung, Andrew L., Bruce, Jeffrey N., Yamashiro, Darrell J., Connolly, Eileen P., Baird, Jason, Crittenden, Marka, Friedman, David, Xiao, Hong, Leidner, Rom, Bell, Bryan, Young, Kristina, Gough, Michael, Bian, Zhen, Kidder, Koby, Liu, Yuan, Curran, Emily, Chen, Xiufen, Corrales, Leticia P., Kline, Justin, Aguilar, Ethan G., Guerriero, Jennifer, Sotayo, Alaba, Ponichtera, Holly, Pourzia, Alexandra, Schad, Sara, Carrasco, Ruben, Lazo, Suzan, Bronson, Roderick, Letai, Anthony, Kornbluth, Richard S., Gupta, Sachin, Termini, James, Guirado, Elizabeth, Stone, Geoffrey W., Meyer, Christina, Helming, Laura, Wilson, Nicholas, Hofmeister, Robert, Neubert, Natalie J., Tillé, Laure, Barras, David, Soneson, Charlotte, Baumgaertner, Petra, Rimoldi, Donata, Gfeller, David, Delorenzi, Mauro, Fuertes Marraco, Silvia A., Speiser, Daniel E., Abraham, Tara S., Xiang, Bo, Magee, Michael S., Waldman, Scott A., Snook, Adam E., Blogowski, Wojciech, Zuba-Surma, Ewa, Budkowska, Marta, Salata, Daria, Dolegowska, Barbara, Starzynska, Teresa, Chan, Leo, Somanchi, Srinivas, McCulley, Kelsey, Lee, Dean, Buettner, Nico, Shi, Feng, Myers, Paisley T., Curbishley, Stuart, Penny, Sarah A., Steadman, Lora, Millar, David, Speers, Ellen, Ruth, Nicola, Wong, Gabriel, Thimme, Robert, Adams, David, Cobbold, Mark, Thomas, Remy, Al-Muftah, Mariam, Wong, Michael KK, Morse, Michael, Clark, Joseph I., Kaufman, Howard L., Daniels, Gregory A., Hua, Hong, Rao, Tharak, Dutcher, Janice P., Kang, Kai, Saunthararajah, Yogen, Velcheti, Vamsidhar, Kumar, Vikas, Anwar, Firoz, Verma, Amita, Chheda, Zinal, Kohanbash, Gary, Sidney, John, Okada, Kaori, Shrivastav, Shruti, Carrera, Diego A., Liu, Shuming, Jahan, Naznin, Mueller, Sabine, Pollack, Ian F., Carcaboso, Angel M., Sette, Alessandro, Hou, Yafei, Okada, Hideho, Field, Jessica J., Zeng, Weiping, Shih, Vincent FS, Law, Che-Leung, Senter, Peter D., Gardai, Shyra J., Okeley, Nicole M., Abelin, Jennifer G., Saeed, Abu Z., Malaker, Stacy A., Shabanowitz, Jeffrey, Ward, Stephen T., Hunt, Donald F., Profusek, Pam, Wood, Laura, Shepard, Dale, Grivas, Petros, Kapp, Kerstin, Volz, Barbara, Oswald, Detlef, Wittig, Burghardt, Schmidt, Manuel, Sefrin, Julian P., Hillringhaus, Lars, Lifke, Valeria, Lifke, Alexander, Skaletskaya, Anna, Ponte, Jose, Chittenden, Thomas, Setiady, Yulius, Sivado, Eva, Thomas, Vincent, El Alaoui, Meddy, Papot, Sébastien, Dumontet, Charles, Dyson, Mike, McCafferty, John, El Alaoui, Said, Bommareddy, Praveen K., Zloza, Andrew, Kohlhapp, Frederick, Silk, Ann W., Jhawar, Sachin, Paneque, Tomas, Newman, Jenna, Beltran, Pedro, Cao, Felicia, Hong, Bang-Xing, Rodriguez-Cruz, Tania, Song, Xiao-Tong, Gottschalk, Stephen, Calderon, Hugo, Illingworth, Sam, Brown, Alice, Fisher, Kerry, Seymour, Len, Champion, Brian, Eriksson, Emma, Wenthe, Jessica, Hellström, Ann-Charlotte, Paul-Wetterberg, Gabriella, Loskog, Angelica, Milenova, Ioanna, Ståhle, Magnus, Jarblad-Leja, Justyna, Ullenhag, Gustav, Dimberg, Anna, Moreno, Rafael, Alemany, Ramon, Goyal, Sharad, Silk, Ann, Mehnert, Janice, Gabrail, Nashat, Bryan, Jennifer, Medina, Daniel, Mitchell, Leah, Yagiz, Kader, Lopez, Fernando, Mendoza, Daniel, Munday, Anthony, Gruber, Harry, Jolly, Douglas, Fuhrmann, Steven, Radoja, Sasa, Tan, Wei, Pourchet, Aldo, Frey, Alan, Mohr, Ian, Mulvey, Matthew, Andtbacka, Robert H. I., Ross, Merrick, Agarwala, Sanjiv, Grossmann, Kenneth, Taylor, Matthew, Vetto, John, Neves, Rogerio, Daud, Adil, Khong, Hung, Meek, Stephanie M., Ungerleider, Richard, Welden, Scott, Tanaka, Maki, Williams, Matthew, Hallmeyer, Sigrun, Fox, Bernard, Feng, Zipei, Paustian, Christopher, Bifulco, Carlo, Zafar, Sadia, Hemminki, Otto, Bramante, Simona, Vassilev, Lotta, Wang, Hongjie, Lieber, Andre, Hemmi, Silvio, de Gruijl, Tanja, Kanerva, Anna, Ansari, Tameem, Sundararaman, Srividya, Roen, Diana, Lehmann, Paul, Bloom, Anja C., Bender, Lewis H., Walters, Ian B., Berzofsky, Jay A., Chapelin, Fanny, Ahrens, Eric T., DeFalco, Jeff, Harbell, Michael, Manning-Bog, Amy, Scholz, Alexander, Zhang, Danhui, Baia, Gilson, Tan, Yann Chong, Sokolove, Jeremy, Kim, Dongkyoon, Williamson, Kevin, Chen, Xiaomu, Colrain, Jillian, Santo, Gregg Espiritu, Nguyen, Ngan, Volkmuth, Wayne, Greenberg, Norman, Robinson, William, Emerling, Daniel, Drake, Charles G., Petrylak, Daniel P., Antonarakis, Emmanuel S., Kibel, Adam S., Chang, Nancy N., Vu, Tuyen, Campogan, Dwayne, Haynes, Heather, Trager, James B., Sheikh, Nadeem A., Quinn, David I., Kirk, Peter, Addepalli, Murali, Chang, Thomas, Zhang, Ping, Konakova, Marina, Hagihara, Katsunobu, Pai, Steven, VanderVeen, Laurie, Obalapur, Palakshi, Kuo, Peiwen, Quach, Phi, Fong, Lawrence, Charych, Deborah H., Zalevsky, Jonathan, Langowski, John L., Kirksey, Yolanda, Nutakki, Ravi, Kolarkar, Shalini, Pena, Rhoneil, Hoch, Ute, Doberstein, Stephen K., Cha, John, Mallon, Zach, Perez, Myra, McDaniel, Amanda, Anand, Snjezana, Uecker, Darrin, Nuccitelli, Richard, Wieckowski, Eva, Muthuswamy, Ravikumar, Ravindranathan, Roshni, Renrick, Ariana N., Thounaojam, Menaka, Thomas, Portia, Pellom, Samuel, Shanker, Anil, Dudimah, Duafalia, Brooks, Alan, Su, Yu-Lin, Adamus, Tomasz, Zhang, Qifang, Nechaev, Sergey, Kortylewski, Marcin, Wei, Spencer, Anderson, Clark, Tang, Chad, Schoenhals, Jonathan, Tsouko, Efrosini, Heymach, John, de Groot, Patricia, Chang, Joe, Hess, Kenneth R., Diab, Adi, Sharma, Padmanee, Hong, David, Welsh, James, Parsons, Andrea J., Leleux, Jardin, Ascarateil, Stephane, Koziol, Marie Eve, Bai, Dina, Dai, Peihong, Wang, Weiyi, Yang, Ning, Shuman, Stewart, Deng, Liang, Dillon, Patrick, Petroni, Gina, Brenin, David, Bullock, Kim, Olson, Walter, Smolkin, Mark E., Smith, Kelly, Nail, Carmel, Slingluff, Craig L., Sharma, Meenu, Fa’ak, Faisal, Janssen, Louise, Khong, Hiep, Xiao, Zhilan, Hailemichael, Yared, Singh, Manisha, Vianden, Christina, Overwijk, Willem W., Facciabene, Andrea, Stefano, Pierini, Chongyung, Fang, Rafail, Stavros, Nielsen, Michael, Vanderslice, Peter, Woodside, Darren G., Market, Robert V., Biediger, Ronald J., Marathi, Upendra K., Hollevoet, Kevin, Geukens, Nick, Declerck, Paul, Joly, Nathalie, McIntosh, Laura, Paramithiotis, Eustache, Rizell, Magnus, Sternby, Malin, Andersson, Bengt, Karlsson-Parra, Alex, Kuai, Rui, Ochyl, Lukasz, Schwendeman, Anna, Moon, James, Deng, Weiwen, Hudson, Thomas E., Hanson, Bill, Rae, Chris S., Burrill, Joel, Skoble, Justin, Katibah, George, deVries, Michele, Lauer, Peter, Dubensky, Thomas W., Chen, Xin, Zhou, Li, Ren, Xiubao, Aggarwal, Charu, Mangrolia, Drishty, Cohen, Roger, Weinstein, Gregory, Morrow, Matthew, Bauml, Joshua, Kraynyak, Kim, Boyer, Jean, Yan, Jian, Lee, Jessica, Humeau, Laurent, Oyola, Sandra, Duff, Susan, Weiner, David, Yang, Zane, Bagarazzi, Mark, McNeel, Douglas G., Eickhoff, Jens, Jeraj, Robert, Staab, Mary Jane, Straus, Jane, Rekoske, Brian, Liu, Glenn, Melssen, Marit, Grosh, William, Varhegyi, Nikole, Galeassi, Nadejda, Deacon, Donna H., Gaughan, Elizabeth, Ghisoli, Maurizio, Barve, Minal, Mennel, Robert, Wallraven, Gladice, Manning, Luisa, Senzer, Neil, Nemunaitis, John, Ogasawara, Masahiro, Ota, Shuichi, Peace, Kaitlin M., Hale, Diane F., Vreeland, Timothy J., Jackson, Doreen O., Berry, John S., Trappey, Alfred F., Herbert, Garth S., Clifton, Guy T., Hardin, Mark O., Toms, Anne, Qiao, Na, Litton, Jennifer, Peoples, George E., Mittendorf, Elizabeth A., Ghamsari, Lila, Flano, Emilio, Jacques, Judy, Liu, Biao, Havel, Jonathan, Makarov, Vladimir, Chan, Timothy A., Flechtner, Jessica B., Facciponte, John, Ugel, Stefano, De Sanctis, Francesco, Coukos, George, Paris, Sébastien, Pottier, Agnes, Levy, Laurent, Lu, Bo, Cappuccini, Federica, Pollock, Emily, Bryant, Richard, Hamdy, Freddie, Hill, Adrian, Redchenko, Irina, Sultan, Hussein, Kumai, Takumi, Fesenkova, Valentyna, Celis, Esteban, Fernando, Ingrid, Palena, Claudia, David, Justin M., Gabitzsch, Elizabeth, Jones, Frank, Gulley, James L., Herranz, Mireia Uribe, Wada, Hiroshi, Shimizu, Atsushi, Osada, Toshihiro, Fukaya, Satoshi, Sasaki, Eiji, Abolhalaj, Milad, Askmyr, David, Lundberg, Kristina, Albrekt, Ann-Sofie, Greiff, Lennart, Lindstedt, Malin, Flies, Dallas B., Higuchi, Tomoe, Ornatowski, Wojciech, Harris, Jaryse, Adams, Sarah F., Aguilera, Todd, Rafat, Marjan, Castellini, Laura, Shehade, Hussein, Kariolis, Mihalis, Jang, Dadi, vonEbyen, Rie, Graves, Edward, Ellies, Lesley, Rankin, Erinn, Koong, Albert, Giaccia, Amato, Ajina, Reham, Wang, Shangzi, Smith, Jill, Pierobon, Mariaelena, Jablonski, Sandra, Petricoin, Emanuel, Weiner, Louis M., Sherry, Lorcan, Waller, John, Anderson, Mark, Bigley, Alison, Bernatchez, Chantale, Haymaker, Cara, Kluger, Harriet, Tetzlaff, Michael, Jackson, Natalie, Gergel, Ivan, Tagliaferri, Mary, Hwu, Patrick, Snzol, Mario, Hurwitz, Michael, Barberi, Theresa, Martin, Allison, Suresh, Rahul, Barakat, David, Harris-Bookman, Sarah, Drake, Charles, Friedman, Alan, Berkey, Sara, Downs-Canner, Stephanie, Edwards, Robert P., Curiel, Tyler, Odunsi, Kunle, Bruno, Tullia C., Moore, Brandon, Squalls, Olivia, Ebner, Peggy, Waugh, Katherine, Mitchell, John, Franklin, Wilbur, Merrick, Daniel, McCarter, Martin, Palmer, Brent, Kern, Jeffrey, Vignali, Dario, Slansky, Jill, Chan, Anissa S. H., Qiu, Xiaohong, Fraser, Kathryn, Jonas, Adria, Ottoson, Nadine, Gordon, Keith, Kangas, Takashi O., Leonardo, Steven, Ertelt, Kathleen, Walsh, Richard, Uhlik, Mark, Graff, Jeremy, Bose, Nandita, Gupta, Ravi, Mandloi, Nitin, Paul, Kiran, Patil, Ashwini, Sathian, Rekha, Mohan, Aparna, Manoharan, Malini, Chaudhuri, Amitabha, Chen, Yu, Lin, Jing, Ye, Yun-bin, Xu, Chun-wei, Chen, Gang, Guo, Zeng-qing, Komarov, Andrey, Chenchik, Alex, Makhanov, Michael, Frangou, Costa, Zheng, Yi, Coltharp, Carla, Unfricht, Darryn, Dilworth, Ryan, Fridman, Leticia, Liu, Linying, Rajopadhye, Milind, Miller, Peter, Concha-Benavente, Fernando, Bauman, Julie, Trivedi, Sumita, Srivastava, Raghvendra, Ohr, James, Heron, Dwight, Duvvuri, Uma, Kim, Seungwon, Torrey, Heather, Mera, Toshi, Okubo, Yoshiaki, Vanamee, Eva, Foster, Rosemary, Faustman, Denise, Stack, Edward, Izaki, Daisuke, Beck, Kristen, Jia, Dan Tong, Armenta, Paul, White-Stern, Ashley, Marks, Douglas, Taback, Bret, Horst, Basil, Glickman, Laura Hix, Kanne, David B., Gauthier, Kelsey S., Desbien, Anthony L., Francica, Brian, Leong, Justin L., Sung, Leonard, Metchette, Ken, Kasibhatla, Shailaja, Pferdekamper, Anne Marie, Zheng, Lianxing, Cho, Charles, Feng, Yan, McKenna, Jeffery M., Tallarico, John, Bender, Steven, Ndubaku, Chudi, McWhirter, Sarah M., Gugel, Elena Gonzalez, Bell, Charles J. M., Munk, Adiel, Muniz, Luciana, Bhardwaj, Nina, Zhao, Fei, Evans, Kathy, Xiao, Christine, Holtzhausen, Alisha, Hanks, Brent A., Scholler, Nathalie, Yin, Catherine, Van der Meijs, Pien, Prantner, Andrew M., Krejsa, Cecile M., Smith, Leia, Johnson, Brian, Branstetter, Daniel, Stein, Paul L., Jaen, Juan C., Tan, Joanne BL, Chen, Ada, Park, Timothy, Powers, Jay P., Sexton, Holly, Xu, Guifen, Young, Steve W., Schindler, Ulrike, Deng, Wentao, Klinke, David John, Komar, Hannah M., Serpa, Gregory, Elnaggar, Omar, Hart, Philip, Schmidt, Carl, Dillhoff, Mary, Jin, Ming, Ostrowski, Michael C., Koti, Madhuri, Au, Katrina, Peterson, Nichole, Truesdell, Peter, Reid-Schachter, Gillian, Graham, Charles, Craig, Andrew, Francis, Julie-Ann, Kotlan, Beatrix, Balatoni, Timea, Farkas, Emil, Toth, Laszlo, Ujhelyi, Mihaly, Savolt, Akos, Doleschall, Zoltan, Horvath, Szabolcs, Eles, Klara, Olasz, Judit, Csuka, Orsolya, Kasler, Miklos, Liszkay, Gabriella, Barnea, Eytan, Blakely, Collin, Flynn, Patrick, Goodman, Reid, Bueno, Raphael, Sugarbaker, David, Jablons, David, Broaddus, V. Courtney, West, Brian, Kunk, Paul R., Obeid, Joseph M., Winters, Kevin, Pramoonjago, Patcharin, Stelow, Edward B., Bauer, Todd W., Rahma, Osama E., Lamble, Adam, Kosaka, Yoko, Huang, Fei, Saser, Kate A., Adams, Homer, Tognon, Christina E., Laderas, Ted, McWeeney, Shannon, Loriaux, Marc, Tyner, Jeffery W., Druker, Brian J., Lind, Evan F., Liu, Zhuqing, Lu, Shanhong, Kane, Lawrence P., Shayan, Gulidanna, Femel, Julia, Lane, Ryan, Booth, Jamie, Lund, Amanda W., Rodriguez, Anthony, Engelhard, Victor H., Metelli, Alessandra, Wu, Bill X., Fugle, Caroline W., Saleh, Rachidi, Sun, Shaoli, Wu, Jennifer, Liu, Bei, Li, Zihai, Morris, Zachary S., Guy, Emily I., Heinze, Clinton, Kler, Jasdeep, Gressett, Monica M., Werner, Lauryn R., Gillies, Stephen D., Korman, Alan J., Loibner, Hans, Hank, Jacquelyn A., Rakhmilevich, Alexander L., Harari, Paul M., Sondel, Paul M., Huelsmann, Erica, Broucek, Joseph, Brech, Dorothee, Straub, Tobias, Irmler, Martin, Beckers, Johannes, Buettner, Florian, Schaeffeler, Elke, Schwab, Matthias, Noessner, Elfriede, Wolfreys, Alison, Da Costa, Andre, Silva, John, Crosby, Andrea, Staelens, Ludovicus, Craggs, Graham, Cauvin, Annick, Mason, Sean, Paterson, Alison M., Lake, Andrew C., Armet, Caroline M., O’Connor, Rachel W., Hill, Jonathan A., Normant, Emmanuel, Adam, Ammar, Biniszkiewicz, Detlev M., Chappel, Scott C., Palombella, Vito J., Holland, Pamela M., Becker, Annette, Leleti, Manmohan R., Newcomb, Eric, Tan, Joanne B. L., Rapisuwon, Suthee, Radfar, Arash, Gardner, Kellie, Gibney, Geoffrey, Atkins, Michael, Rennier, Keith R., Crowder, Robert, Wang, Ping, Pachynski, Russell K., Carrero, Rosa M. Santana, Rivas, Sarai, Beceren-Braun, Figen, Anthony, Scott, Schluns, Kimberly S., Sawant, Deepali, Chikina, Maria, Yano, Hiroshi, Workman, Creg, Salerno, Elise, Mauldin, Ileana, Deacon, Donna, Shea, Sofia, Pinczewski, Joel, Gajewski, Thomas, Spranger, Stefani, Horton, Brendan, Suzuki, Akiko, Leland, Pamela, Joshi, Bharat H., Puri, Raj K., Sweis, Randy F., Bao, Riyue, Luke, Jason, Theodoraki, Marie-Nicole, Mogundo, Frances-Mary, Won, Haejung, Moreira, Dayson, Gao, Chan, Zhao, Xingli, Duttagupta, Priyanka, Jones, Jeremy, D’Apuzzo, Massimo, and Pal, Sumanta

Subjects
Meeting Abstracts
Published
2016

16. 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two

Author

Ager, Casey, primary, Reilley, Matthew, additional, Nicholas, Courtney, additional, Bartkowiak, Todd, additional, Jaiswal, Ashvin, additional, Curran, Michael, additional, Albershardt, Tina C., additional, Bajaj, Anshika, additional, Archer, Jacob F., additional, Reeves, Rebecca S., additional, Ngo, Lisa Y., additional, Berglund, Peter, additional, ter Meulen, Jan, additional, Denis, Caroline, additional, Ghadially, Hormas, additional, Arnoux, Thomas, additional, Chanuc, Fabien, additional, Fuseri, Nicolas, additional, Wilkinson, Robert W., additional, Wagtmann, Nicolai, additional, Morel, Yannis, additional, Andre, Pascale, additional, Atkins, Michael B., additional, Carlino, Matteo S., additional, Ribas, Antoni, additional, Thompson, John A., additional, Choueiri, Toni K., additional, Hodi, F. Stephen, additional, Hwu, Wen-Jen, additional, McDermott, David F., additional, Atkinson, Victoria, additional, Cebon, Jonathan S., additional, Fitzharris, Bernie, additional, Jameson, Michael B., additional, McNeil, Catriona, additional, Hill, Andrew G., additional, Mangin, Eric, additional, Ahamadi, Malidi, additional, van Vugt, Marianne, additional, van Zutphen, Mariëlle, additional, Ibrahim, Nageatte, additional, Long, Georgina V., additional, Gartrell, Robyn, additional, Blake, Zoe, additional, Simoes, Ines, additional, Fu, Yichun, additional, Saito, Takuro, additional, Qian, Yingzhi, additional, Lu, Yan, additional, Saenger, Yvonne M., additional, Budhu, Sadna, additional, De Henau, Olivier, additional, Zappasodi, Roberta, additional, Schlunegger, Kyle, additional, Freimark, Bruce, additional, Hutchins, Jeff, additional, Barker, Christopher A., additional, Wolchok, Jedd D., additional, Merghoub, Taha, additional, Burova, Elena, additional, Allbritton, Omaira, additional, Hong, Peter, additional, Dai, Jie, additional, Pei, Jerry, additional, Liu, Matt, additional, Kantrowitz, Joel, additional, Lai, Venus, additional, Poueymirou, William, additional, MacDonald, Douglas, additional, Ioffe, Ella, additional, Mohrs, Markus, additional, Olson, William, additional, Thurston, Gavin, additional, Capasso, Cristian, additional, Frascaro, Federica, additional, Carpi, Sara, additional, Tähtinen, Siri, additional, Feola, Sara, additional, Fusciello, Manlio, additional, Peltonen, Karita, additional, Martins, Beatriz, additional, Sjöberg, Madeleine, additional, Pesonen, Sari, additional, Ranki, Tuuli, additional, Kyruk, Lukasz, additional, Ylösmäki, Erkko, additional, Cerullo, Vincenzo, additional, Cerignoli, Fabio, additional, Xi, Biao, additional, Guenther, Garret, additional, Yu, Naichen, additional, Muir, Lincoln, additional, Zhao, Leyna, additional, Abassi, Yama, additional, Cervera-Carrascón, Víctor, additional, Siurala, Mikko, additional, Santos, João, additional, Havunen, Riikka, additional, Parviainen, Suvi, additional, Hemminki, Akseli, additional, Dalgleish, Angus, additional, Mudan, Satvinder, additional, DeBenedette, Mark, additional, Plachco, Ana, additional, Gamble, Alicia, additional, Grogan, Elizabeth W., additional, Krisko, John, additional, Tcherepanova, Irina, additional, Nicolette, Charles, additional, Dhupkar, Pooja, additional, Yu, Ling, additional, Kleinerman, Eugenie S., additional, Gordon, Nancy, additional, Grenga, Italia, additional, Lepone, Lauren, additional, Gameiro, Sofia, additional, Knudson, Karin M., additional, Fantini, Massimo, additional, Tsang, Kwong, additional, Hodge, James, additional, Donahue, Renee, additional, Schlom, Jeffrey, additional, Evans, Elizabeth, additional, Bussler, Holm, additional, Mallow, Crystal, additional, Reilly, Christine, additional, Torno, Sebold, additional, Scrivens, Maria, additional, Foster, Cathie, additional, Howell, Alan, additional, Balch, Leslie, additional, Knapp, Alyssa, additional, Leonard, John E., additional, Paris, Mark, additional, Fisher, Terry, additional, Hu-Lieskovan, Siwen, additional, Smith, Ernest, additional, Zauderer, Maurice, additional, Fogler, William, additional, Franklin, Marilyn, additional, Thayer, Matt, additional, Saims, Dan, additional, Magnani, John L., additional, Gong, Jian, additional, Gray, Michael, additional, Fromm, George, additional, de Silva, Suresh, additional, Giffin, Louise, additional, Xu, Xin, additional, Rose, Jason, additional, Schreiber, Taylor H., additional, Gameiro, Sofia R., additional, Clavijo, Paul E., additional, Allen, Clint T., additional, Hodge, James W., additional, Tsang, Kwong Y., additional, Grogan, Jane, additional, Manieri, Nicholas, additional, Chiang, Eugene, additional, Caplazi, Patrick, additional, Yadav, Mahesh, additional, Hagner, Patrick, additional, Chiu, Hsiling, additional, Waldman, Michelle, additional, Klippel, Anke, additional, Thakurta, Anjan, additional, Pourdehnad, Michael, additional, Gandhi, Anita, additional, Henrich, Ian, additional, Quick, Laura, additional, Young, Rob, additional, Chou, Margaret, additional, Hotson, Andrew, additional, Willingham, Stephen, additional, Ho, Po, additional, Choy, Carmen, additional, Laport, Ginna, additional, McCaffery, Ian, additional, Miller, Richard, additional, Tipton, Kimberly A., additional, Wong, Kenneth R., additional, Singson, Victoria, additional, Wong, Chihunt, additional, Chan, Chanty, additional, Huang, Yuanhiu, additional, Liu, Shouchun, additional, Richardson, Jennifer H., additional, Kavanaugh, W. Michael, additional, West, James, additional, Irving, Bryan A., additional, Jaini, Ritika, additional, Loya, Matthew, additional, Eng, Charis, additional, Johnson, Melissa L., additional, Adjei, Alex A., additional, Opyrchal, Mateusz, additional, Ramalingam, Suresh, additional, Janne, Pasi A., additional, Dominguez, George, additional, Gabrilovich, Dmitry, additional, de Leon, Laura, additional, Hasapidis, Jeannette, additional, Diede, Scott J., additional, Ordentlich, Peter, additional, Cruickshank, Scott, additional, Meyers, Michael L., additional, Hellmann, Matthew D., additional, Kalinski, Pawel, additional, Zureikat, Amer, additional, Edwards, Robert, additional, Muthuswamy, Ravi, additional, Obermajer, Nataša, additional, Urban, Julie, additional, Butterfield, Lisa H., additional, Gooding, William, additional, Zeh, Herbert, additional, Bartlett, David, additional, Zubkova, Olga, additional, Agapova, Larissa, additional, Kapralova, Marina, additional, Krasovskaia, Liudmila, additional, Ovsepyan, Armen, additional, Lykov, Maxim, additional, Eremeev, Artem, additional, Bokovanov, Vladimir, additional, Grigoryeva, Olga, additional, Karpov, Andrey, additional, Ruchko, Sergey, additional, Shuster, Alexandr, additional, Khalil, Danny N., additional, Campesato, Luis Felipe, additional, Li, Yanyun, additional, Lazorchak, Adam S., additional, Patterson, Troy D., additional, Ding, Yueyun, additional, Sasikumar, Pottayil, additional, Sudarshan, Naremaddepalli, additional, Gowda, Nagaraj, additional, Ramachandra, Raghuveer, additional, Samiulla, Dodheri, additional, Giri, Sanjeev, additional, Eswarappa, Rajesh, additional, Ramachandra, Murali, additional, Tuck, David, additional, Wyant, Timothy, additional, Leshem, Jasmin, additional, Liu, Xiu-fen, additional, Bera, Tapan, additional, Terabe, Masaki, additional, Bossenmaier, Birgit, additional, Niederfellner, Gerhard, additional, Reiter, Yoram, additional, Pastan, Ira, additional, Xia, Leiming, additional, Xia, Yang, additional, Hu, Yangyang, additional, Wang, Yi, additional, Bao, Yangyi, additional, Dai, Fu, additional, Huang, Shiang, additional, Hurt, Elaine, additional, Hollingsworth, Robert E., additional, Lum, Lawrence G., additional, Chang, Alfred E., additional, Wicha, Max S., additional, Li, Qiao, additional, Mace, Thomas, additional, Makhijani, Neil, additional, Talbert, Erin, additional, Young, Gregory, additional, Guttridge, Denis, additional, Conwell, Darwin, additional, Lesinski, Gregory B., additional, Gonzales, Rodney JM Macedo, additional, Huffman, Austin P., additional, Wang, Ximi K., additional, Reshef, Ran, additional, MacKinnon, Andy, additional, Chen, Jason, additional, Gross, Matt, additional, Marguier, Gisele, additional, Shwonek, Peter, additional, Sotirovska, Natalija, additional, Steggerda, Susanne, additional, Parlati, Francesco, additional, Makkouk, Amani, additional, Bennett, Mark K., additional, Emberley, Ethan, additional, Huang, Tony, additional, Li, Weiqun, additional, Neou, Silinda, additional, Pan, Alison, additional, Zhang, Jing, additional, Zhang, Winter, additional, Marshall, Netonia, additional, Marron, Thomas U., additional, Agudo, Judith, additional, Brown, Brian, additional, Brody, Joshua, additional, McQuinn, Christopher, additional, Farren, Matthew, additional, Komar, Hannah, additional, Shakya, Reena, additional, Ludwug, Thomas, additional, Morillon, Y. Maurice, additional, Hammond, Scott A., additional, Greiner, John W., additional, Nath, Pulak R., additional, Schwartz, Anthony L., additional, Maric, Dragan, additional, Roberts, David D., additional, Naing, Aung, additional, Papadopoulos, Kyriakos P., additional, Autio, Karen A., additional, Wong, Deborah J., additional, Patel, Manish, additional, Falchook, Gerald, additional, Pant, Shubham, additional, Ott, Patrick A., additional, Whiteside, Melinda, additional, Patnaik, Amita, additional, Mumm, John, additional, Janku, Filip, additional, Chan, Ivan, additional, Bauer, Todd, additional, Colen, Rivka, additional, VanVlasselaer, Peter, additional, Brown, Gail L., additional, Tannir, Nizar M., additional, Oft, Martin, additional, Infante, Jeffrey, additional, Lipson, Evan, additional, Gopal, Ajay, additional, Neelapu, Sattva S., additional, Armand, Philippe, additional, Spurgeon, Stephen, additional, Leonard, John P., additional, Sanborn, Rachel E., additional, Melero, Ignacio, additional, Gajewski, Thomas F., additional, Maurer, Matthew, additional, Perna, Serena, additional, Gutierrez, Andres A., additional, Clynes, Raphael, additional, Mitra, Priyam, additional, Suryawanshi, Satyendra, additional, Gladstone, Douglas, additional, Callahan, Margaret K., additional, Crooks, James, additional, Brown, Sheila, additional, Gauthier, Audrey, additional, de Boisferon, Marc Hillairet, additional, MacDonald, Andrew, additional, Brunet, Laura Rosa, additional, Rothwell, William T., additional, Bell, Peter, additional, Wilson, James M., additional, Sato-Kaneko, Fumi, additional, Yao, Shiyin, additional, Zhang, Shannon S., additional, Carson, Dennis A., additional, Guiducci, Cristina, additional, Coffman, Robert L., additional, Kitaura, Kazutaka, additional, Matsutani, Takaji, additional, Suzuki, Ryuji, additional, Hayashi, Tomoko, additional, Cohen, Ezra E. W., additional, Schaer, David, additional, Li, Yanxia, additional, Dobkin, Julie, additional, Amatulli, Michael, additional, Hall, Gerald, additional, Doman, Thompson, additional, Manro, Jason, additional, Dorsey, Frank Charles, additional, Sams, Lillian, additional, Holmgaard, Rikke, additional, Persaud, Krishnadatt, additional, Ludwig, Dale, additional, Surguladze, David, additional, Kauh, John S., additional, Novosiadly, Ruslan, additional, Kalos, Michael, additional, Driscoll, Kyla, additional, Pandha, Hardev, additional, Ralph, Christy, additional, Harrington, Kevin, additional, Curti, Brendan, additional, Akerley, Wallace, additional, Gupta, Sumati, additional, Melcher, Alan, additional, Mansfield, David, additional, Kaufman, David R., additional, Schmidt, Emmett, additional, Grose, Mark, additional, Davies, Bronwyn, additional, Karpathy, Roberta, additional, Shafren, Darren, additional, Shamalov, Katerina, additional, Cohen, Cyrille, additional, Sharma, Naveen, additional, Allison, James, additional, Shekarian, Tala, additional, Valsesia-Wittmann, Sandrine, additional, Caux, Christophe, additional, Marabelle, Aurelien, additional, Slomovitz, Brian M., additional, Moore, Kathleen M., additional, Youssoufian, Hagop, additional, Posner, Marshall, additional, Tewary, Poonam, additional, Brooks, Alan D., additional, Xu, Ya-Ming, additional, Wijeratne, Kithsiri, additional, Gunatilaka, Leslie A. A., additional, Sayers, Thomas J., additional, Vasilakos, John P., additional, Alston, Tesha, additional, Dovedi, Simon, additional, Elvecrog, James, additional, Grigsby, Iwen, additional, Herbst, Ronald, additional, Johnson, Karen, additional, Moeckly, Craig, additional, Mullins, Stefanie, additional, Siebenaler, Kristen, additional, SternJohn, Julius, additional, Tilahun, Ashenafi, additional, Tomai, Mark A., additional, Vogel, Katharina, additional, Vietsch, Eveline E., additional, Wellstein, Anton, additional, Wythes, Martin, additional, Crosignani, Stefano, additional, Tumang, Joseph, additional, Alekar, Shilpa, additional, Bingham, Patrick, additional, Cauwenberghs, Sandra, additional, Chaplin, Jenny, additional, Dalvie, Deepak, additional, Denies, Sofie, additional, De Maeseneire, Coraline, additional, Feng, JunLi, additional, Frederix, Kim, additional, Greasley, Samantha, additional, Guo, Jie, additional, Hardwick, James, additional, Kaiser, Stephen, additional, Jessen, Katti, additional, Kindt, Erick, additional, Letellier, Marie-Claire, additional, Li, Wenlin, additional, Maegley, Karen, additional, Marillier, Reece, additional, Miller, Nichol, additional, Murray, Brion, additional, Pirson, Romain, additional, Preillon, Julie, additional, Rabolli, Virginie, additional, Ray, Chad, additional, Ryan, Kevin, additional, Scales, Stephanie, additional, Srirangam, Jay, additional, Solowiej, Jim, additional, Stewart, Al, additional, Streiner, Nicole, additional, Torti, Vince, additional, Tsaparikos, Konstantinos, additional, Zheng, Xianxian, additional, Driessens, Gregory, additional, Gomes, Bruno, additional, Kraus, Manfred, additional, Xu, Chunxiao, additional, Zhang, Yanping, additional, Kradjian, Giorgio, additional, Qin, Guozhong, additional, Qi, Jin, additional, Xu, Xiaomei, additional, Marelli, Bo, additional, Yu, Huakui, additional, Guzman, Wilson, additional, Tighe, Rober, additional, Salazar, Rachel, additional, Lo, Kin-Ming, additional, English, Jessie, additional, Radvanyi, Laszlo, additional, Lan, Yan, additional, Postow, Michael, additional, Senbabaoglu, Yasin, additional, Gasmi, Billel, additional, Zhong, Hong, additional, Liu, Cailian, additional, Hirschhorhn-Cymerman, Daniel, additional, Zha, Yuanyuan, additional, Malnassy, Gregory, additional, Fulton, Noreen, additional, Park, Jae-Hyun, additional, Stock, Wendy, additional, Nakamura, Yusuke, additional, Liu, Hongtao, additional, Ju, Xiaoming, additional, Kosoff, Rachelle, additional, Ramos, Kimberly, additional, Coder, Brandon, additional, Petit, Robert, additional, Princiotta, Michael, additional, Perry, Kyle, additional, Zou, Jun, additional, Arina, Ainhoa, additional, Fernandez, Christian, additional, Zheng, Wenxin, additional, Beckett, Michael A., additional, Mauceri, Helena J., additional, Fu, Yang-Xin, additional, Weichselbaum, Ralph R., additional, Lewis, Whitney, additional, Han, Yanyan, additional, Wu, Yeting, additional, Yang, Chou, additional, Huang, Jing, additional, Wu, Dongyun, additional, Li, Jin, additional, Liang, Xiaoling, additional, Zhou, Xiangjun, additional, Hou, Jinlin, additional, Hassan, Raffit, additional, Jahan, Thierry, additional, Antonia, Scott J., additional, Kindler, Hedy L., additional, Alley, Evan W., additional, Honarmand, Somayeh, additional, Liu, Weiqun, additional, Leong, Meredith L., additional, Whiting, Chan C., additional, Nair, Nitya, additional, Enstrom, Amanda, additional, Lemmens, Edward E., additional, Tsujikawa, Takahiro, additional, Kumar, Sushil, additional, Coussens, Lisa M., additional, Murphy, Aimee L., additional, Brockstedt, Dirk G., additional, Koch, Sven D., additional, Sebastian, Martin, additional, Weiss, Christian, additional, Früh, Martin, additional, Pless, Miklos, additional, Cathomas, Richard, additional, Hilbe, Wolfgang, additional, Pall, Georg, additional, Wehler, Thomas, additional, Alt, Jürgen, additional, Bischoff, Helge, additional, Geissler, Michael, additional, Griesinger, Frank, additional, Kollmeier, Jens, additional, Papachristofilou, Alexandros, additional, Doener, Fatma, additional, Fotin-Mleczek, Mariola, additional, Hipp, Madeleine, additional, Hong, Henoch S., additional, Kallen, Karl-Josef, additional, Klinkhardt, Ute, additional, Stosnach, Claudia, additional, Scheel, Birgit, additional, Schroeder, Andreas, additional, Seibel, Tobias, additional, Gnad-Vogt, Ulrike, additional, Zippelius, Alfred, additional, Park, Ha-Ram, additional, Ahn, Yong-Oon, additional, Kim, Tae Min, additional, Kim, Soyeon, additional, Kim, Seulki, additional, Lee, Yu Soo, additional, Keam, Bhumsuk, additional, Kim, Dong-Wan, additional, Heo, Dae Seog, additional, Pilon-Thomas, Shari, additional, Weber, Amy, additional, Morse, Jennifer, additional, Kodumudi, Krithika, additional, Liu, Hao, additional, Mullinax, John, additional, Sarnaik, Amod A., additional, Pike, Luke, additional, Bang, Andrew, additional, Balboni, Tracy, additional, Taylor, Allison, additional, Spektor, Alexander, additional, Wilhite, Tyler, additional, Krishnan, Monica, additional, Cagney, Daniel, additional, Alexander, Brian, additional, Aizer, Ayal, additional, Buchbinder, Elizabeth, additional, Awad, Mark, additional, Ghandi, Leena, additional, Schoenfeld, Jonathan, additional, Lessey-Morillon, Elizabeth, additional, Ridnour, Lisa, additional, Segal, Neil H., additional, Sharma, Manish, additional, Le, Dung T., additional, Ferris, Robert L., additional, Zelenetz, Andrew D., additional, Levy, Ronald, additional, Lossos, Izidore S., additional, Jacobson, Caron, additional, Ramchandren, Radhakrishnan, additional, Godwin, John, additional, Colevas, A. Dimitrios, additional, Meier, Roland, additional, Krishnan, Suba, additional, Gu, Xuemin, additional, Neely, Jaclyn, additional, Timmerman, John, additional, Vanpouille-Box, Claire I., additional, Formenti, Silvia C., additional, Demaria, Sandra, additional, Wennerberg, Erik, additional, Mediero, Aranzazu, additional, Cronstein, Bruce N., additional, Gustafson, Michael P., additional, DiCostanzo, AriCeli, additional, Wheatley, Courtney, additional, Kim, Chul-Ho, additional, Bornschlegl, Svetlana, additional, Gastineau, Dennis A., additional, Johnson, Bruce D., additional, Dietz, Allan B., additional, MacDonald, Cameron, additional, Bucsek, Mark, additional, Qiao, Guanxi, additional, Hylander, Bonnie, additional, Repasky, Elizabeth, additional, Turbitt, William J., additional, Xu, Yitong, additional, Mastro, Andrea, additional, Rogers, Connie J., additional, Withers, Sita, additional, Wang, Ziming, additional, Khuat, Lam T., additional, Dunai, Cordelia, additional, Blazar, Bruce R., additional, Longo, Dan, additional, Rebhun, Robert, additional, Grossenbacher, Steven K., additional, Monjazeb, Arta, additional, Murphy, William J., additional, Rowlinson, Scott, additional, Agnello, Giulia, additional, Alters, Susan, additional, Lowe, David, additional, Scharping, Nicole, additional, Menk, Ashley V., additional, Whetstone, Ryan, additional, Zeng, Xue, additional, Delgoffe, Greg M., additional, Santos, Patricia M., additional, Shi, Jian, additional, Delgoffe, Greg, additional, Nagasaka, Misako, additional, Sukari, Ammar, additional, Byrne-Steele, Miranda, additional, Pan, Wenjing, additional, Hou, Xiaohong, additional, Brown, Brittany, additional, Eisenhower, Mary, additional, Han, Jian, additional, Collins, Natalie, additional, Manguso, Robert, additional, Pope, Hans, additional, Shrestha, Yashaswi, additional, Boehm, Jesse, additional, Haining, W. Nicholas, additional, Cron, Kyle R., additional, Sivan, Ayelet, additional, Aquino-Michaels, Keston, additional, Orecchioni, Marco, additional, Bedognetti, Davide, additional, Hendrickx, Wouter, additional, Fuoco, Claudia, additional, Spada, Filomena, additional, Sgarrella, Francesco, additional, Cesareni, Gianni, additional, Marincola, Francesco, additional, Kostarelos, Kostas, additional, Bianco, Alberto, additional, Delogu, Lucia, additional, Roelands, Jessica, additional, Boughorbel, Sabri, additional, Decock, Julie, additional, Presnell, Scott, additional, Wang, Ena, additional, Marincola, Franco M., additional, Kuppen, Peter, additional, Ceccarelli, Michele, additional, Rinchai, Darawan, additional, Chaussabel, Damien, additional, Miller, Lance, additional, Nguyen, Andrew, additional, Sanborn, J. Zachary, additional, Vaske, Charles, additional, Rabizadeh, Shahrooz, additional, Niazi, Kayvan, additional, Benz, Steven, additional, Patel, Shashank, additional, Restifo, Nicholas, additional, White, James, additional, Angiuoli, Sam, additional, Sausen, Mark, additional, Jones, Sian, additional, Sevdali, Maria, additional, Simmons, John, additional, Velculescu, Victor, additional, Diaz, Luis, additional, Zhang, Theresa, additional, Sims, Jennifer S., additional, Barton, Sunjay M., additional, Kadenhe-Chiweshe, Angela, additional, Dela Cruz, Filemon, additional, Turk, Andrew T., additional, Mazzeo, Christopher F., additional, Kung, Andrew L., additional, Bruce, Jeffrey N., additional, Yamashiro, Darrell J., additional, Connolly, Eileen P., additional, Baird, Jason, additional, Crittenden, Marka, additional, Friedman, David, additional, Xiao, Hong, additional, Leidner, Rom, additional, Bell, Bryan, additional, Young, Kristina, additional, Gough, Michael, additional, Bian, Zhen, additional, Kidder, Koby, additional, Liu, Yuan, additional, Curran, Emily, additional, Chen, Xiufen, additional, Corrales, Leticia P., additional, Kline, Justin, additional, Aguilar, Ethan G., additional, Guerriero, Jennifer, additional, Sotayo, Alaba, additional, Ponichtera, Holly, additional, Pourzia, Alexandra, additional, Schad, Sara, additional, Carrasco, Ruben, additional, Lazo, Suzan, additional, Bronson, Roderick, additional, Letai, Anthony, additional, Kornbluth, Richard S., additional, Gupta, Sachin, additional, Termini, James, additional, Guirado, Elizabeth, additional, Stone, Geoffrey W., additional, Meyer, Christina, additional, Helming, Laura, additional, Wilson, Nicholas, additional, Hofmeister, Robert, additional, Neubert, Natalie J., additional, Tillé, Laure, additional, Barras, David, additional, Soneson, Charlotte, additional, Baumgaertner, Petra, additional, Rimoldi, Donata, additional, Gfeller, David, additional, Delorenzi, Mauro, additional, Fuertes Marraco, Silvia A., additional, Speiser, Daniel E., additional, Abraham, Tara S., additional, Xiang, Bo, additional, Magee, Michael S., additional, Waldman, Scott A., additional, Snook, Adam E., additional, Blogowski, Wojciech, additional, Zuba-Surma, Ewa, additional, Budkowska, Marta, additional, Salata, Daria, additional, Dolegowska, Barbara, additional, Starzynska, Teresa, additional, Chan, Leo, additional, Somanchi, Srinivas, additional, McCulley, Kelsey, additional, Lee, Dean, additional, Buettner, Nico, additional, Shi, Feng, additional, Myers, Paisley T., additional, Curbishley, Stuart, additional, Penny, Sarah A., additional, Steadman, Lora, additional, Millar, David, additional, Speers, Ellen, additional, Ruth, Nicola, additional, Wong, Gabriel, additional, Thimme, Robert, additional, Adams, David, additional, Cobbold, Mark, additional, Thomas, Remy, additional, Al-Muftah, Mariam, additional, Wong, Michael KK, additional, Morse, Michael, additional, Clark, Joseph I., additional, Kaufman, Howard L., additional, Daniels, Gregory A., additional, Hua, Hong, additional, Rao, Tharak, additional, Dutcher, Janice P., additional, Kang, Kai, additional, Saunthararajah, Yogen, additional, Velcheti, Vamsidhar, additional, Kumar, Vikas, additional, Anwar, Firoz, additional, Verma, Amita, additional, Chheda, Zinal, additional, Kohanbash, Gary, additional, Sidney, John, additional, Okada, Kaori, additional, Shrivastav, Shruti, additional, Carrera, Diego A., additional, Liu, Shuming, additional, Jahan, Naznin, additional, Mueller, Sabine, additional, Pollack, Ian F., additional, Carcaboso, Angel M., additional, Sette, Alessandro, additional, Hou, Yafei, additional, Okada, Hideho, additional, Field, Jessica J., additional, Zeng, Weiping, additional, Shih, Vincent FS, additional, Law, Che-Leung, additional, Senter, Peter D., additional, Gardai, Shyra J., additional, Okeley, Nicole M., additional, Abelin, Jennifer G., additional, Saeed, Abu Z., additional, Malaker, Stacy A., additional, Shabanowitz, Jeffrey, additional, Ward, Stephen T., additional, Hunt, Donald F., additional, Profusek, Pam, additional, Wood, Laura, additional, Shepard, Dale, additional, Grivas, Petros, additional, Kapp, Kerstin, additional, Volz, Barbara, additional, Oswald, Detlef, additional, Wittig, Burghardt, additional, Schmidt, Manuel, additional, Sefrin, Julian P., additional, Hillringhaus, Lars, additional, Lifke, Valeria, additional, Lifke, Alexander, additional, Skaletskaya, Anna, additional, Ponte, Jose, additional, Chittenden, Thomas, additional, Setiady, Yulius, additional, Sivado, Eva, additional, Thomas, Vincent, additional, El Alaoui, Meddy, additional, Papot, Sébastien, additional, Dumontet, Charles, additional, Dyson, Mike, additional, McCafferty, John, additional, El Alaoui, Said, additional, Bommareddy, Praveen K., additional, Zloza, Andrew, additional, Kohlhapp, Frederick, additional, Silk, Ann W., additional, Jhawar, Sachin, additional, Paneque, Tomas, additional, Newman, Jenna, additional, Beltran, Pedro, additional, Cao, Felicia, additional, Hong, Bang-Xing, additional, Rodriguez-Cruz, Tania, additional, Song, Xiao-Tong, additional, Gottschalk, Stephen, additional, Calderon, Hugo, additional, Illingworth, Sam, additional, Brown, Alice, additional, Fisher, Kerry, additional, Seymour, Len, additional, Champion, Brian, additional, Eriksson, Emma, additional, Wenthe, Jessica, additional, Hellström, Ann-Charlotte, additional, Paul-Wetterberg, Gabriella, additional, Loskog, Angelica, additional, Milenova, Ioanna, additional, Ståhle, Magnus, additional, Jarblad-Leja, Justyna, additional, Ullenhag, Gustav, additional, Dimberg, Anna, additional, Moreno, Rafael, additional, Alemany, Ramon, additional, Goyal, Sharad, additional, Silk, Ann, additional, Mehnert, Janice, additional, Gabrail, Nashat, additional, Bryan, Jennifer, additional, Medina, Daniel, additional, Mitchell, Leah, additional, Yagiz, Kader, additional, Lopez, Fernando, additional, Mendoza, Daniel, additional, Munday, Anthony, additional, Gruber, Harry, additional, Jolly, Douglas, additional, Fuhrmann, Steven, additional, Radoja, Sasa, additional, Tan, Wei, additional, Pourchet, Aldo, additional, Frey, Alan, additional, Mohr, Ian, additional, Mulvey, Matthew, additional, Andtbacka, Robert H. I., additional, Ross, Merrick, additional, Agarwala, Sanjiv, additional, Grossmann, Kenneth, additional, Taylor, Matthew, additional, Vetto, John, additional, Neves, Rogerio, additional, Daud, Adil, additional, Khong, Hung, additional, Meek, Stephanie M., additional, Ungerleider, Richard, additional, Welden, Scott, additional, Tanaka, Maki, additional, Williams, Matthew, additional, Hallmeyer, Sigrun, additional, Fox, Bernard, additional, Feng, Zipei, additional, Paustian, Christopher, additional, Bifulco, Carlo, additional, Zafar, Sadia, additional, Hemminki, Otto, additional, Bramante, Simona, additional, Vassilev, Lotta, additional, Wang, Hongjie, additional, Lieber, Andre, additional, Hemmi, Silvio, additional, de Gruijl, Tanja, additional, Kanerva, Anna, additional, Ansari, Tameem, additional, Sundararaman, Srividya, additional, Roen, Diana, additional, Lehmann, Paul, additional, Bloom, Anja C., additional, Bender, Lewis H., additional, Walters, Ian B., additional, Berzofsky, Jay A., additional, Chapelin, Fanny, additional, Ahrens, Eric T., additional, DeFalco, Jeff, additional, Harbell, Michael, additional, Manning-Bog, Amy, additional, Scholz, Alexander, additional, Zhang, Danhui, additional, Baia, Gilson, additional, Tan, Yann Chong, additional, Sokolove, Jeremy, additional, Kim, Dongkyoon, additional, Williamson, Kevin, additional, Chen, Xiaomu, additional, Colrain, Jillian, additional, Santo, Gregg Espiritu, additional, Nguyen, Ngan, additional, Volkmuth, Wayne, additional, Greenberg, Norman, additional, Robinson, William, additional, Emerling, Daniel, additional, Drake, Charles G., additional, Petrylak, Daniel P., additional, Antonarakis, Emmanuel S., additional, Kibel, Adam S., additional, Chang, Nancy N., additional, Vu, Tuyen, additional, Campogan, Dwayne, additional, Haynes, Heather, additional, Trager, James B., additional, Sheikh, Nadeem A., additional, Quinn, David I., additional, Kirk, Peter, additional, Addepalli, Murali, additional, Chang, Thomas, additional, Zhang, Ping, additional, Konakova, Marina, additional, Hagihara, Katsunobu, additional, Pai, Steven, additional, VanderVeen, Laurie, additional, Obalapur, Palakshi, additional, Kuo, Peiwen, additional, Quach, Phi, additional, Fong, Lawrence, additional, Charych, Deborah H., additional, Zalevsky, Jonathan, additional, Langowski, John L., additional, Kirksey, Yolanda, additional, Nutakki, Ravi, additional, Kolarkar, Shalini, additional, Pena, Rhoneil, additional, Hoch, Ute, additional, Doberstein, Stephen K., additional, Cha, John, additional, Mallon, Zach, additional, Perez, Myra, additional, McDaniel, Amanda, additional, Anand, Snjezana, additional, Uecker, Darrin, additional, Nuccitelli, Richard, additional, Wieckowski, Eva, additional, Muthuswamy, Ravikumar, additional, Ravindranathan, Roshni, additional, Renrick, Ariana N., additional, Thounaojam, Menaka, additional, Thomas, Portia, additional, Pellom, Samuel, additional, Shanker, Anil, additional, Dudimah, Duafalia, additional, Brooks, Alan, additional, Su, Yu-Lin, additional, Adamus, Tomasz, additional, Zhang, Qifang, additional, Nechaev, Sergey, additional, Kortylewski, Marcin, additional, Wei, Spencer, additional, Anderson, Clark, additional, Tang, Chad, additional, Schoenhals, Jonathan, additional, Tsouko, Efrosini, additional, Heymach, John, additional, de Groot, Patricia, additional, Chang, Joe, additional, Hess, Kenneth R., additional, Diab, Adi, additional, Sharma, Padmanee, additional, Hong, David, additional, Welsh, James, additional, Parsons, Andrea J., additional, Leleux, Jardin, additional, Ascarateil, Stephane, additional, Koziol, Marie Eve, additional, Bai, Dina, additional, Dai, Peihong, additional, Wang, Weiyi, additional, Yang, Ning, additional, Shuman, Stewart, additional, Deng, Liang, additional, Dillon, Patrick, additional, Petroni, Gina, additional, Brenin, David, additional, Bullock, Kim, additional, Olson, Walter, additional, Smolkin, Mark E., additional, Smith, Kelly, additional, Nail, Carmel, additional, Slingluff, Craig L., additional, Sharma, Meenu, additional, Fa’ak, Faisal, additional, Janssen, Louise, additional, Khong, Hiep, additional, Xiao, Zhilan, additional, Hailemichael, Yared, additional, Singh, Manisha, additional, Vianden, Christina, additional, Overwijk, Willem W., additional, Facciabene, Andrea, additional, Stefano, Pierini, additional, Chongyung, Fang, additional, Rafail, Stavros, additional, Nielsen, Michael, additional, Vanderslice, Peter, additional, Woodside, Darren G., additional, Market, Robert V., additional, Biediger, Ronald J., additional, Marathi, Upendra K., additional, Hollevoet, Kevin, additional, Geukens, Nick, additional, Declerck, Paul, additional, Joly, Nathalie, additional, McIntosh, Laura, additional, Paramithiotis, Eustache, additional, Rizell, Magnus, additional, Sternby, Malin, additional, Andersson, Bengt, additional, Karlsson-Parra, Alex, additional, Kuai, Rui, additional, Ochyl, Lukasz, additional, Schwendeman, Anna, additional, Moon, James, additional, Deng, Weiwen, additional, Hudson, Thomas E., additional, Hanson, Bill, additional, Rae, Chris S., additional, Burrill, Joel, additional, Skoble, Justin, additional, Katibah, George, additional, deVries, Michele, additional, Lauer, Peter, additional, Dubensky, Thomas W., additional, Chen, Xin, additional, Zhou, Li, additional, Ren, Xiubao, additional, Aggarwal, Charu, additional, Mangrolia, Drishty, additional, Cohen, Roger, additional, Weinstein, Gregory, additional, Morrow, Matthew, additional, Bauml, Joshua, additional, Kraynyak, Kim, additional, Boyer, Jean, additional, Yan, Jian, additional, Lee, Jessica, additional, Humeau, Laurent, additional, Oyola, Sandra, additional, Duff, Susan, additional, Weiner, David, additional, Yang, Zane, additional, Bagarazzi, Mark, additional, McNeel, Douglas G., additional, Eickhoff, Jens, additional, Jeraj, Robert, additional, Staab, Mary Jane, additional, Straus, Jane, additional, Rekoske, Brian, additional, Liu, Glenn, additional, Melssen, Marit, additional, Grosh, William, additional, Varhegyi, Nikole, additional, Galeassi, Nadejda, additional, Deacon, Donna H., additional, Gaughan, Elizabeth, additional, Ghisoli, Maurizio, additional, Barve, Minal, additional, Mennel, Robert, additional, Wallraven, Gladice, additional, Manning, Luisa, additional, Senzer, Neil, additional, Nemunaitis, John, additional, Ogasawara, Masahiro, additional, Ota, Shuichi, additional, Peace, Kaitlin M., additional, Hale, Diane F., additional, Vreeland, Timothy J., additional, Jackson, Doreen O., additional, Berry, John S., additional, Trappey, Alfred F., additional, Herbert, Garth S., additional, Clifton, Guy T., additional, Hardin, Mark O., additional, Toms, Anne, additional, Qiao, Na, additional, Litton, Jennifer, additional, Peoples, George E., additional, Mittendorf, Elizabeth A., additional, Ghamsari, Lila, additional, Flano, Emilio, additional, Jacques, Judy, additional, Liu, Biao, additional, Havel, Jonathan, additional, Makarov, Vladimir, additional, Chan, Timothy A., additional, Flechtner, Jessica B., additional, Facciponte, John, additional, Ugel, Stefano, additional, De Sanctis, Francesco, additional, Coukos, George, additional, Paris, Sébastien, additional, Pottier, Agnes, additional, Levy, Laurent, additional, Lu, Bo, additional, Cappuccini, Federica, additional, Pollock, Emily, additional, Bryant, Richard, additional, Hamdy, Freddie, additional, Hill, Adrian, additional, Redchenko, Irina, additional, Sultan, Hussein, additional, Kumai, Takumi, additional, Fesenkova, Valentyna, additional, Celis, Esteban, additional, Fernando, Ingrid, additional, Palena, Claudia, additional, David, Justin M., additional, Gabitzsch, Elizabeth, additional, Jones, Frank, additional, Gulley, James L., additional, Herranz, Mireia Uribe, additional, Wada, Hiroshi, additional, Shimizu, Atsushi, additional, Osada, Toshihiro, additional, Fukaya, Satoshi, additional, Sasaki, Eiji, additional, Abolhalaj, Milad, additional, Askmyr, David, additional, Lundberg, Kristina, additional, Albrekt, Ann-Sofie, additional, Greiff, Lennart, additional, Lindstedt, Malin, additional, Flies, Dallas B., additional, Higuchi, Tomoe, additional, Ornatowski, Wojciech, additional, Harris, Jaryse, additional, Adams, Sarah F., additional, Aguilera, Todd, additional, Rafat, Marjan, additional, Castellini, Laura, additional, Shehade, Hussein, additional, Kariolis, Mihalis, additional, Jang, Dadi, additional, vonEbyen, Rie, additional, Graves, Edward, additional, Ellies, Lesley, additional, Rankin, Erinn, additional, Koong, Albert, additional, Giaccia, Amato, additional, Ajina, Reham, additional, Wang, Shangzi, additional, Smith, Jill, additional, Pierobon, Mariaelena, additional, Jablonski, Sandra, additional, Petricoin, Emanuel, additional, Weiner, Louis M., additional, Sherry, Lorcan, additional, Waller, John, additional, Anderson, Mark, additional, Bigley, Alison, additional, Bernatchez, Chantale, additional, Haymaker, Cara, additional, Kluger, Harriet, additional, Tetzlaff, Michael, additional, Jackson, Natalie, additional, Gergel, Ivan, additional, Tagliaferri, Mary, additional, Hwu, Patrick, additional, Snzol, Mario, additional, Hurwitz, Michael, additional, Barberi, Theresa, additional, Martin, Allison, additional, Suresh, Rahul, additional, Barakat, David, additional, Harris-Bookman, Sarah, additional, Drake, Charles, additional, Friedman, Alan, additional, Berkey, Sara, additional, Downs-Canner, Stephanie, additional, Edwards, Robert P., additional, Curiel, Tyler, additional, Odunsi, Kunle, additional, Bruno, Tullia C., additional, Moore, Brandon, additional, Squalls, Olivia, additional, Ebner, Peggy, additional, Waugh, Katherine, additional, Mitchell, John, additional, Franklin, Wilbur, additional, Merrick, Daniel, additional, McCarter, Martin, additional, Palmer, Brent, additional, Kern, Jeffrey, additional, Vignali, Dario, additional, Slansky, Jill, additional, Chan, Anissa S. H., additional, Qiu, Xiaohong, additional, Fraser, Kathryn, additional, Jonas, Adria, additional, Ottoson, Nadine, additional, Gordon, Keith, additional, Kangas, Takashi O., additional, Leonardo, Steven, additional, Ertelt, Kathleen, additional, Walsh, Richard, additional, Uhlik, Mark, additional, Graff, Jeremy, additional, Bose, Nandita, additional, Gupta, Ravi, additional, Mandloi, Nitin, additional, Paul, Kiran, additional, Patil, Ashwini, additional, Sathian, Rekha, additional, Mohan, Aparna, additional, Manoharan, Malini, additional, Chaudhuri, Amitabha, additional, Chen, Yu, additional, Lin, Jing, additional, Ye, Yun-bin, additional, Xu, Chun-wei, additional, Chen, Gang, additional, Guo, Zeng-qing, additional, Komarov, Andrey, additional, Chenchik, Alex, additional, Makhanov, Michael, additional, Frangou, Costa, additional, Zheng, Yi, additional, Coltharp, Carla, additional, Unfricht, Darryn, additional, Dilworth, Ryan, additional, Fridman, Leticia, additional, Liu, Linying, additional, Rajopadhye, Milind, additional, Miller, Peter, additional, Concha-Benavente, Fernando, additional, Bauman, Julie, additional, Trivedi, Sumita, additional, Srivastava, Raghvendra, additional, Ohr, James, additional, Heron, Dwight, additional, Duvvuri, Uma, additional, Kim, Seungwon, additional, Torrey, Heather, additional, Mera, Toshi, additional, Okubo, Yoshiaki, additional, Vanamee, Eva, additional, Foster, Rosemary, additional, Faustman, Denise, additional, Stack, Edward, additional, Izaki, Daisuke, additional, Beck, Kristen, additional, Jia, Dan Tong, additional, Armenta, Paul, additional, White-Stern, Ashley, additional, Marks, Douglas, additional, Taback, Bret, additional, Horst, Basil, additional, Glickman, Laura Hix, additional, Kanne, David B., additional, Gauthier, Kelsey S., additional, Desbien, Anthony L., additional, Francica, Brian, additional, Leong, Justin L., additional, Sung, Leonard, additional, Metchette, Ken, additional, Kasibhatla, Shailaja, additional, Pferdekamper, Anne Marie, additional, Zheng, Lianxing, additional, Cho, Charles, additional, Feng, Yan, additional, McKenna, Jeffery M., additional, Tallarico, John, additional, Bender, Steven, additional, Ndubaku, Chudi, additional, McWhirter, Sarah M., additional, Gugel, Elena Gonzalez, additional, Bell, Charles J. M., additional, Munk, Adiel, additional, Muniz, Luciana, additional, Bhardwaj, Nina, additional, Zhao, Fei, additional, Evans, Kathy, additional, Xiao, Christine, additional, Holtzhausen, Alisha, additional, Hanks, Brent A., additional, Scholler, Nathalie, additional, Yin, Catherine, additional, Van der Meijs, Pien, additional, Prantner, Andrew M., additional, Krejsa, Cecile M., additional, Smith, Leia, additional, Johnson, Brian, additional, Branstetter, Daniel, additional, Stein, Paul L., additional, Jaen, Juan C., additional, Tan, Joanne BL, additional, Chen, Ada, additional, Park, Timothy, additional, Powers, Jay P., additional, Sexton, Holly, additional, Xu, Guifen, additional, Young, Steve W., additional, Schindler, Ulrike, additional, Deng, Wentao, additional, Klinke, David John, additional, Komar, Hannah M., additional, Serpa, Gregory, additional, Elnaggar, Omar, additional, Hart, Philip, additional, Schmidt, Carl, additional, Dillhoff, Mary, additional, Jin, Ming, additional, Ostrowski, Michael C., additional, Koti, Madhuri, additional, Au, Katrina, additional, Peterson, Nichole, additional, Truesdell, Peter, additional, Reid-Schachter, Gillian, additional, Graham, Charles, additional, Craig, Andrew, additional, Francis, Julie-Ann, additional, Kotlan, Beatrix, additional, Balatoni, Timea, additional, Farkas, Emil, additional, Toth, Laszlo, additional, Ujhelyi, Mihaly, additional, Savolt, Akos, additional, Doleschall, Zoltan, additional, Horvath, Szabolcs, additional, Eles, Klara, additional, Olasz, Judit, additional, Csuka, Orsolya, additional, Kasler, Miklos, additional, Liszkay, Gabriella, additional, Barnea, Eytan, additional, Blakely, Collin, additional, Flynn, Patrick, additional, Goodman, Reid, additional, Bueno, Raphael, additional, Sugarbaker, David, additional, Jablons, David, additional, Broaddus, V. Courtney, additional, West, Brian, additional, Kunk, Paul R., additional, Obeid, Joseph M., additional, Winters, Kevin, additional, Pramoonjago, Patcharin, additional, Stelow, Edward B., additional, Bauer, Todd W., additional, Rahma, Osama E., additional, Lamble, Adam, additional, Kosaka, Yoko, additional, Huang, Fei, additional, Saser, Kate A., additional, Adams, Homer, additional, Tognon, Christina E., additional, Laderas, Ted, additional, McWeeney, Shannon, additional, Loriaux, Marc, additional, Tyner, Jeffery W., additional, Druker, Brian J., additional, Lind, Evan F., additional, Liu, Zhuqing, additional, Lu, Shanhong, additional, Kane, Lawrence P., additional, Shayan, Gulidanna, additional, Femel, Julia, additional, Lane, Ryan, additional, Booth, Jamie, additional, Lund, Amanda W., additional, Rodriguez, Anthony, additional, Engelhard, Victor H., additional, Metelli, Alessandra, additional, Wu, Bill X., additional, Fugle, Caroline W., additional, Saleh, Rachidi, additional, Sun, Shaoli, additional, Wu, Jennifer, additional, Liu, Bei, additional, Li, Zihai, additional, Morris, Zachary S., additional, Guy, Emily I., additional, Heinze, Clinton, additional, Kler, Jasdeep, additional, Gressett, Monica M., additional, Werner, Lauryn R., additional, Gillies, Stephen D., additional, Korman, Alan J., additional, Loibner, Hans, additional, Hank, Jacquelyn A., additional, Rakhmilevich, Alexander L., additional, Harari, Paul M., additional, Sondel, Paul M., additional, Huelsmann, Erica, additional, Broucek, Joseph, additional, Brech, Dorothee, additional, Straub, Tobias, additional, Irmler, Martin, additional, Beckers, Johannes, additional, Buettner, Florian, additional, Schaeffeler, Elke, additional, Schwab, Matthias, additional, Noessner, Elfriede, additional, Wolfreys, Alison, additional, Da Costa, Andre, additional, Silva, John, additional, Crosby, Andrea, additional, Staelens, Ludovicus, additional, Craggs, Graham, additional, Cauvin, Annick, additional, Mason, Sean, additional, Paterson, Alison M., additional, Lake, Andrew C., additional, Armet, Caroline M., additional, O’Connor, Rachel W., additional, Hill, Jonathan A., additional, Normant, Emmanuel, additional, Adam, Ammar, additional, Biniszkiewicz, Detlev M., additional, Chappel, Scott C., additional, Palombella, Vito J., additional, Holland, Pamela M., additional, Becker, Annette, additional, Leleti, Manmohan R., additional, Newcomb, Eric, additional, Tan, Joanne B. L., additional, Rapisuwon, Suthee, additional, Radfar, Arash, additional, Gardner, Kellie, additional, Gibney, Geoffrey, additional, Atkins, Michael, additional, Rennier, Keith R., additional, Crowder, Robert, additional, Wang, Ping, additional, Pachynski, Russell K., additional, Carrero, Rosa M. Santana, additional, Rivas, Sarai, additional, Beceren-Braun, Figen, additional, Anthony, Scott, additional, Schluns, Kimberly S., additional, Sawant, Deepali, additional, Chikina, Maria, additional, Yano, Hiroshi, additional, Workman, Creg, additional, Salerno, Elise, additional, Mauldin, Ileana, additional, Deacon, Donna, additional, Shea, Sofia, additional, Pinczewski, Joel, additional, Gajewski, Thomas, additional, Spranger, Stefani, additional, Horton, Brendan, additional, Suzuki, Akiko, additional, Leland, Pamela, additional, Joshi, Bharat H., additional, Puri, Raj K., additional, Sweis, Randy F., additional, Bao, Riyue, additional, Luke, Jason, additional, Theodoraki, Marie-Nicole, additional, Mogundo, Frances-Mary, additional, Won, Haejung, additional, Moreira, Dayson, additional, Gao, Chan, additional, Zhao, Xingli, additional, Duttagupta, Priyanka, additional, Jones, Jeremy, additional, D’Apuzzo, Massimo, additional, and Pal, Sumanta, additional

Published
2016
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17. The Human Vaccines Project: A roadmap for cancer vaccine development

Author

Romero, Pedro, primary, Banchereau, Jacques, additional, Bhardwaj, Nina, additional, Cockett, Mark, additional, Disis, Mary L., additional, Dranoff, Glenn, additional, Gilboa, Eli, additional, Hammond, Scott A., additional, Hershberg, Robert, additional, Korman, Alan J., additional, Kvistborg, Pia, additional, Melief, Cornelis, additional, Mellman, Ira, additional, Palucka, A. Karolina, additional, Redchenko, Irina, additional, Robins, Harlan, additional, Sallusto, Federica, additional, Schenkelberg, Theodore, additional, Schoenberger, Stephen, additional, Sosman, Jeffrey, additional, Türeci, Özlem, additional, Van den Eynde, Benoît, additional, Koff, Wayne, additional, and Coukos, George, additional

Published
2016
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18. Vaccination of colorectal cancer patients with TroVax given alongside chemotherapy (5-fluorouracil, leukovorin and irinotecan) is safe and induces potent immune responses

Author

Harrop, Richard, primary, Drury, Noel, additional, Shingler, William, additional, Chikoti, Priscilla, additional, Redchenko, Irina, additional, Carroll, Miles W., additional, Kingsman, Susan M., additional, Naylor, Stuart, additional, Griffiths, Richard, additional, Steven, Neil, additional, and Hawkins, Robert E., additional

Published
2007
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19. Vaccination of Colorectal Cancer Patients with Modified Vaccinia Ankara Encoding the Tumor Antigen 5T4 (TroVax) Given Alongside Chemotherapy Induces Potent Immune Responses

Author

Harrop, Richard, primary, Drury, Noel, additional, Shingler, William, additional, Chikoti, Priscilla, additional, Redchenko, Irina, additional, Carroll, Miles W., additional, Kingsman, Susan M., additional, Naylor, Stuart, additional, Melcher, Alan, additional, Nicholls, Joanna, additional, Wassan, Harpreet, additional, Habib, Nagy, additional, and Anthoney, Alan, additional

Published
2007
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20. Vaccination of Colorectal Cancer Patients with Modified Vaccinia Ankara Delivering the Tumor Antigen 5T4 (TroVax) Induces Immune Responses which Correlate with Disease Control: A Phase I/II Trial

Author

Harrop, Richard, primary, Connolly, Noel, additional, Redchenko, Irina, additional, Valle, Juan, additional, Saunders, Mark, additional, Ryan, Matthew G., additional, Myers, Kevin A., additional, Drury, Noel, additional, Kingsman, Susan M., additional, Hawkins, Robert E., additional, and Carroll, Miles W., additional

Published
2006
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22. Vaccination Against the Tumour Associated Antigen 5T4 Induces Immune Responses in Advanced Colorectal Cancer Patients: Results Phase I/II Clinical Trial with Recombinant Modified Vaccinia Virus Ankara(TroVax)

Author

Hawkins, Robert, primary, Connolly, Noel, additional, Harrop, Richard, additional, Redchenko, Irina, additional, Ryan, Matthew, additional, Drury, Noel, additional, Kelleher, Michelle, additional, Kingsman, Sue, additional, and Carroll, Miles, additional

Published
2004
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23. Monitoring of Human Immunological Responses to Vaccinia Virus.

Author

Walker, John M., Isaacs, Stuart N., Harrop, Richard, Ryan, Matthew G., Golding, Hana, Redchenko, Irina, and Carroll, Miles W.

Abstract

For the last 30 yr, interest in vaccinia virus immune monitoring has focused on the use of the vaccinia virus as a recombinant vaccine vector and the potential detrimental effect of antivector immunity on subsequent vaccination with a recombinant vaccinia virus. However, interest in this area has intensified after the publication of reports suggesting that smallpox may be a major pathogen selected for bioterrorist activities. Owing to the unacceptably high incidence of complications induced by previous effective smallpox vaccine strains, alternative safer strains (e.g., modified vaccinia Ankara [MVA]) are being assessed for their antigenicity in clinical trials. The exact immune effector mechanism responsible for vaccine-induced protection to smallpox infection has not been fully elucidated, although it is believed that neutralizing antibody plays a major role. This chapter describes a simple enzyme-linked immunosorbent assay (ELISA) to quantify vaccinia virus antibody titer. Additionally, to define serum-neutralizing activity, both a classical plaque reduction assay and a high-throughput 96-well plate method based on reduction of recombinant vaccinia virus expressed β-galactosidase is described. Furthermore, details are given for a T-cell proliferation assay, primarily for monitoring T-helper CD4 activity and an enzyme-linked immunospot (ELISPOT) assay for CD8 analysis. The use of reliable immunological assays is vital in assessing the potential efficacy of new vaccines to protect against smallpox infection. [ABSTRACT FROM AUTHOR]

Published
2004
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26. Active treatment of murine tumors with a highly attenuated vaccinia virus expressing the tumor associated antigen 5T4 (TroVax) is CD4+ T cell dependent and antibody mediated.

Author

Harrop, Richard, Ryan, Matthew G., Myers, Kevin A., Redchenko, Irina, Kingsman, Susan M., and Carroll, Miles W.

Subjects
TUMORS, RODENTS, T cells, IMMUNOGLOBULINS, VIRUSES, MURINE sarcoma viruses
Abstract

5T4 is a tumor associated antigen that is expressed on the surface of a wide spectrum of human adenocarcinomas. The highly attenuated virus, modified vaccinia Ankara, has been engineered to express human 5T4 (h5T4). In a pre-clinical murine model, the recombinant virus (TroVax) induces protection against challenge with CT26–h5T4 (a syngeneic tumor line expressing h5T4). Anti-tumor activity is long lived, with protection still evident 6 months after the final vaccination. In a therapeutic setting, injection of mice with TroVax results in a reduction in tumor burden of >90%. Depletion of CD8+ T cells has no effect upon therapy in the active treatment model, whereas depletion of CD4+ T cells completely abrogates anti-tumor activity. In a prophylactic setting, depletion of CD4+ and CD8+ T cells after the induction of a h5T4 immune response has no deleterious effect on protection following challenge with CT26–h5T4. In light of these studies, the role of antibodies in protection against tumor challenge was investigated. 5T4 specific polyclonal serum decreased tumor burden by approximately 70%. Thus, we conclude that CD4+ T cells are essential for the induction of a protective immune response and that antibodies are the likely effector moiety in this xenogeneic murine tumor model. [ABSTRACT FROM AUTHOR]

Published
2006
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27. Human CD8+T Cell Responses to EBV EBNA1: HLA Class I Presentation of the (Gly-Ala)–Containing Protein Requires Exogenous Processing

Author

Blake, Neil, Lee, Steven, Redchenko, Irina, Thomas, Wendy, Steven, Neil, Leese, Alison, Steigerwald-Mullen, Patty, Kurilla, Michael G, Frappier, Lori, and Rickinson, Alan

Abstract

Epstein-Barr virus (EBV)–induced cytotoxic T lymphocyte (CTL) responses have been detected against many EBV antigens but not the nuclear antigen EBNA1; this has been attributed to the presence of a glycine-alanine repeat (GAr) domain in the protein. Here we describe the isolation of human CD8+CTL clones recognizing EBNA1-specific peptides in the context of HLA-B35.01 and HLA-A2.03. Using these clones, we show that full-length EBNA1 is not presented when expressed endogenously in target cells, whereas the GAr-deleted form is presented efficiently. However, when supplied as an exogenous antigen, the full-length protein can be presented on HLA class I molecules by a TAP-independent pathway; this may explain how EBNA1-specific CTLs are primed in vivo.

Published
1997
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29. Monitoring of human immunological responses to vaccinia virus.

Author

Harrop R, Ryan MG, Golding H, Redchenko I, and Carroll MW

Subjects
CD8-Positive T-Lymphocytes immunology, Enzyme-Linked Immunosorbent Assay, Humans, Immune System, Neutralization Tests, Smallpox Vaccine administration & dosage, Vaccinia virus physiology, Antibodies, Viral blood, Smallpox Vaccine immunology, Vaccinia immunology, Vaccinia virus immunology
Abstract

For the last 30 yr, interest in vaccinia virus immune monitoring has focused on the use of the vaccinia virus as a recombinant vaccine vector and the potential detrimental effect of antivector immunity on subsequent vaccination with a recombinant vaccinia virus. However, interest in this area has intensified after the publication of reports suggesting that smallpox may be a major pathogen selected for bioterrorist activities. Owing to the unacceptably high incidence of complications induced by previous effective smallpox vaccine strains, alternative safer strains (e.g., modified vaccinia Ankara [MVA]) are being assessed for their antigenicity in clinical trials. The exact immune effector mechanism responsible for vaccine-induced protection to smallpox infection has not been fully elucidated, although it is believed that neutralizing antibody plays a major role. This chapter describes a simple enzyme-linked immunosorbent assay (ELISA) to quantify vaccinia virus antibody titer. Additionally, to define serum-neutralizing activity, both a classical plaque reduction assay and a high-throughput 96-well plate method based on reduction of recombinant vaccinia virus expressed beta-galactosidase is described. Furthermore, details are given for a T-cell proliferation assay, primarily for monitoring T-helper CD4 activity and an enzyme-linked immunospot (ELISPOT) assay for CD8 analysis. The use of reliable immunological assays is vital in assessing the potential efficacy of new vaccines to protect against smallpox infection.

Published
2004
Full Text
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