47 results on '"Reche-Frutos J"'
Search Results
2. Assessment of vision-related quality of life and depression and anxiety rates in patients with neovascular age-related macular degeneration
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Fernández-Vigo, J.I., Burgos-Blasco, B., Calvo-González, C., Escobar-Moreno, M.J., Shi, H., Jiménez-Santos, M., Valverde-Megías, A., Reche-Frutos, J., López-Guajardo, L., and Donate-López, J.
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- 2021
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3. Comparison of Goldmann applanation and dynamic contour tonometry measurements: Effects of corneal morphometry
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Sáenz-Francés, F., García-Catalán, R., Jerez-Fidalgo, M., Fernández-Vidal, A., Martínez-de-la-Casa, J.M., Méndez-Hernández, C., Santos-Bueso, E., Reche-Frutos, J., García-Sánchez, J., and García-Feijoo, J.
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- 2011
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4. Assessment of the perception of healthcare barriers and the impact of intravitreal injections on neovascular age-related macular degeneration
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Fernández-Vigo, J.I., primary, Burgos-Blasco, B., additional, Calvo-González, C., additional, Escobar, M.J., additional, Shi, H., additional, Jiménez-Santos, M., additional, Valverde-Megías, A., additional, Reche-Frutos, J., additional, López-Guajardo, L., additional, and Donate-López, J., additional
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- 2021
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5. Evaluación de la percepción de las barreras en la asistencia sanitaria y del impacto de las inyecciones intravítreas en la degeneración macular asociada a la edad neovascular
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Fernández-Vigo, J.I., primary, Burgos-Blasco, B., additional, Calvo-González, C., additional, Escobar, M.J., additional, Shi, H., additional, Jiménez-Santos, M., additional, Valverde-Megías, A., additional, Reche-Frutos, J., additional, López-Guajardo, L., additional, and Donate-López, J., additional
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- 2021
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6. Evaluación de la calidad de vida y la presencia de síntomas de depresión y ansiedad en pacientes con degeneración macular asociada a la edad neovascular
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Fernández-Vigo, J.I., primary, Burgos-Blasco, B., additional, Calvo-González, C., additional, Escobar-Moreno, M.J., additional, Shi, H., additional, Jiménez-Santos, M., additional, Valverde-Megías, A., additional, Reche-Frutos, J., additional, López-Guajardo, L., additional, and Donate-López, J., additional
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- 2021
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7. Angle-closure glaucoma after piggyback intraocular lens implantation
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GARCÍA-FEIJOO, J., SÁENZ-FRANCÉS, F., MARTÍNEZ-DE-LA-CASA, J. M., MÉNDEZ-HERNÁNDEZ, C., FERNÁNDEZ-VIDAL, A., ELÍAS-DE-TEJADA, M., RECHE-FRUTOS, J., and GARCÍA-SÁNCHEZ, J.
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- 2008
8. Short-term anatomic effect of ranibizumab for polypoidal choroidal vasculopathy
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RECHE-FRUTOS, J., CALVO-GONZALEZ, C., DONATE-LOPEZ, J., GARCIA-FEIJOO, J., LEILA, M., and GARCIA-SANCHEZ, J.
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- 2008
9. Combined Pegaptanib sodium (Macugen) and photodynamic therapy in predominantly classic juxtafoveal choroidal neovascularisation in age related macular degeneration
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Calvo-González, C, Reche-Frutos, J, Donate-López, J, García-Feijoó, J, Leila, M, Fernández-Pérez, C, and Garcia-Sánchez, J
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- 2008
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10. Retinal angiomatous proliferation reactivation 6 months after high-dose intravitreal acetonide triamcinolone and photodynamic therapy
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RECHE-FRUTOS, J., CALVO-GONZALEZ, C., DONATE-LOPEZ, J., GARCIA-FEIJOO, J., SAENZ-FRANCES, F., FERNANDEZ-PEREZ, C., and GARCIA-SANCHEZ, J.
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- 2007
11. Comparison of Goldmann applanation and dynamic contour tonometry measurements: Effects of corneal morphometry
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Federico Saenz-Frances, Julian Garcia-Feijoo, A. Fernandez-Vidal, Reche-Frutos J, Carmen Mendez-Hernandez, Julián García-Sánchez, M. Jerez-Fidalgo, Enrique Santos-Bueso, Jose M. Martinez-de-la-Casa, and R. García-Catalán
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Tonometría de contorno dinámico ,Male ,medicine.medical_specialty ,Multivariate statistics ,Intraocular pressure ,Intraclass correlation ,Glaucoma ,Goldmann applanation tonometry ,Cornea ,Tonometry, Ocular ,Bias ,Ophthalmology ,Humans ,Medicine ,Intraocular Pressure ,Aged ,Anthropometry ,business.industry ,Age Factors ,Healthy subjects ,Reproducibility of Results ,Confounding Factors, Epidemiologic ,General Medicine ,Middle Aged ,medicine.disease ,Dynamic contour tonometry ,Confidence interval ,Tonometría de aplanación de Goldmann ,Multivariate Analysis ,Female ,Ocular Hypertension ,business - Abstract
Objetivos: Determinar la concordancia entre la presión intraocular (PIO) medida mediante tonometría de aplanación de Goldmann (TAG) y tonometría de contorno dinámico (TCD). Métodos: La PIO se midió mediante TAG y TCD en 63 ojos de 63 voluntarios sanos. La concordancia se determinó mediante coeficiente de correlación intraclase (CCI). Se empleó el método de Passing-Bablok para establecer la presencia de sesgos proporcionales y/o sistemáticos. El análisis de regresión multvariable se empleó para determinar si las diferencias estaban condicionadas por la potencia de los ejes mayor y menor de la córnea, por su orientación, por el grosor corneal central (GCC) y por la edad. Resultados: El CCI fue 0,57 (intervalo de confianza [IC] al 95%: 0,29-0,74). La diferencia media entre los dos instrumentos fue 1,68 mmHg (TCD menos TAG) (IC 95%: 0,92-2,44). El análisis de Passing-Bablok (X=DCT, Y=GAT) reveló la presencia de un sesgo sistemático (A=-14,35, IC 95%: -24,51-[-9,14]) y otro proporcional (B=1,74, IC 95%: 1,43-2,26). El análisis de regresión multivariable mostró una total independencia del TCD de las características corneales mientras que la TAG estaba afectada por el GCC (B=0,042 CI 95%: 0,002-0,082). Conclusiones: La TCD se mostró independiente de las características morfométricas de la córnea mientras que la TAG se afectó por el GCC. Objectives: To compare intraocular pressure (IOP) measurements made by Goldmann applanation tonometry (GAT) and dynamic contour tonometry (DCT). Methods: IOPs were measured by GAT and DCT in 63 eyes of 63 healthy subjects. A comparison was made by intraclass correlation coefficient. Passing-Bablok plot was constructed to establish the existence of systematic and/or proportional biases. Multivariate regression analysis was used to examine whether the measurements of both instruments were affected by the power of the steepest and flattest corneal axes, their orientation, age or central corneal thickness (CCT). Results: The intra-class correlations (ICCs) were 0.57 (95% confidence interval (95% CI): 0.29-0.74). Mean differences were 1.68 (DCT minus GAT) (95% CI: 0.92-2.44). Passing-Bablok analysis (X=DCT, Y=GAT) revealed a systematic bias (A=-14.35, 95% CI: -24.51-[-9.14]) and a proportional bias (B=1.74, 95% CI: 1.43-2.26). Multivariate regression analysis revealed that the DCT was independent of the corneal characteristics analysed while GAT was biased by CCT (B=0.042, 95% CI: 0.002-0.082). Conclusions: While GAT was biased by corneal CCT; DCT readings were independent of corneal morphometry.
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- 2011
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12. Concordancia entre la tonometría de aplanación de Goldmann y la tonometría de contorno dinámico: efectos de la morfometría corneal
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Jose M. Martinez-de-la-Casa, Julian Garcia-Feijoo, Enrique Santos-Bueso, R. García-Catalán, A. Fernandez-Vidal, Reche-Frutos J, Federico Saenz-Frances, Carmen Mendez-Hernandez, Julián García-Sánchez, and M. Jerez-Fidalgo
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Tonometría de contorno dinámico ,Ophthalmology ,Tonometría de aplanación de Goldmann ,Glaucoma - Abstract
Resumen Objetivos Determinar la concordancia entre la presion intraocular (PIO) medida mediante tonometria de aplanacion de Goldmann (TAG) y tonometria de contorno dinamico (TCD). Metodos La PIO se midio mediante TAG y TCD en 63 ojos de 63 voluntarios sanos. La concordancia se determino mediante coeficiente de correlacion intraclase (CCI). Se empleo el metodo de Passing-Bablok para establecer la presencia de sesgos proporcionales y/o sistematicos. El analisis de regresion multvariable se empleo para determinar si las diferencias estaban condicionadas por la potencia de los ejes mayor y menor de la cornea, por su orientacion, por el grosor corneal central (GCC) y por la edad. Resultados El CCI fue 0,57 (intervalo de confianza [IC] al 95%: 0,29-0,74). La diferencia media entre los dos instrumentos fue 1,68 mmHg (TCD menos TAG) (IC 95%: 0,92-2,44). El analisis de Passing-Bablok (X=DCT, Y=GAT) revelo la presencia de un sesgo sistematico (A=-14,35, IC 95%: -24,51-[-9,14]) y otro proporcional (B=1,74, IC 95%: 1,43-2,26). El analisis de regresion multivariable mostro una total independencia del TCD de las caracteristicas corneales mientras que la TAG estaba afectada por el GCC (B=0,042 CI 95%: 0,002-0,082). Conclusiones La TCD se mostro independiente de las caracteristicas morfometricas de la cornea mientras que la TAG se afecto por el GCC.
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- 2011
13. Choroidal metastasis from a breast carcinoma: Diagnosis and follow-up with optical coherence tomography and fluorescein angiography and autofluorescence with HRA-II (Heidelberg Retina Angiograph)
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Pérez-Álvarez, M.J., Arriola-Villalobos, P., Reche-Frutos, J., and García-Sánchez, J.
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genetic structures ,OCT ,Choroidal metastasis ,Metástasis coroideas ,sense organs ,HRA-II ,Fluorescein Angiography ,AFG ,eye diseases - Abstract
Caso clínico: Mujer de 69 años que desarrolló metástasis coroideas unilaterales a partir de un carcinoma de mama, tratado con cirugía y quimioterapia. Evaluamos la resolución del desprendimiento seroso retiniano mediante tomografía de coherencia óptica (OCT) y angiofluoresceingrafía (AFG) tras quimioterapia y radioterapia externa, y la posterior recidiva en el nervio óptico. Discusión: La OCT resulta útil en el diagnóstico de cambios secundarios retinianos, aunque su valor es más limitado en la localización inicial de las lesiones. Sin embargo, es de gran utilidad en el seguimiento. La autofluorescencia permite detectar actividad exudativa tumoral, incluso sin cambios evidentes en AFG u OCT. Clinical case: A 69-year-old woman developed choroidal metastasis from a breast carcinoma 2 years after the initial diagnosis, surgery and chemotherapy. After treatment with palliative chemotherapy and external radiotherapy, we used fluorescein angiography (FA) and optical coherence tomography (OCT) to evaluate the resolution of the serous retinal detachment, as well as a later relapse in the optic nerve. Discussion: OCT is useful in the follow-up of choroidal metastasis after treatment. However, OCT imaging is limited by the initial choroidal location of metastasis. The autofluorescence can detect exudative tumoral activity even without obvious changes in OCT or FA.
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- 2009
14. Photodynamic therapy in severe chronic central serous chorioretinopaty
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Reche-Frutos, J., Calvo-González, C., Donate-López, J., Sáenz-Francés-San-Baldomero, F., Cerván-López, I., García-Feijoó, J., and García-Sánchez, J.
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optical coherence tomography ,genetic structures ,angiografía con verde de indocianina ,chronic central serous chorioretinopathy ,choroidal hyperpermeability ,Terapia fotodinámica ,coriorretinopatía serosa central crónica ,tomografía de coherencia óptica ,sense organs ,eye diseases ,hipermeabilidad coroidea ,Photodynamic therapy ,indocyanine green angiography - Abstract
Objetivo: Determinar la eficacia y seguridad de la terapia fotodinámica en coriorretinopatía serosa central crónica (CSC) Métodos: Se incluyen pacientes con formas crónicas de CSC y signos de actividad de la enfermedad tratados con terapia fotodinámica. Se lleva a cabo una exploración oftamológica completa incluyendo la medida de mejor agudeza visual corregida (MAVC) en optotipo ETDRS, angiografía con fluoresceína (AFG) y verde de indocianina (AVI) y tomografía de coherencia óptica (OCT). El objetivo primario del estudio es determinar el cambio medio en agudeza visual. Resultados: Se han incluido 11 ojos de 11 pacientes. La MAVC media ha pasado de 20/76 a 20/64. El 35% de los ojos mejoraron su MAVC en dos o más líneas, en el 45% se mantuvo estable y el 18% perdieron dos o más líneas. En todos los casos se redujo la hiperpermeabilidad coroidea y en un 80% el desprendimiento de retina neurosensorial. Todos los pacientes recibieron un solo tratamiento salvo un caso que requirió dos por la aparición de una neovascularización coroidea (NVC). En otro caso se apreció incremento de la atrofia sobre el epitelio pigmentario de la retina (EPR). El seguimiento medio ha sido de 11 meses. Conclusiones: La administración de TFD en pacientes con CSC crónica mejora especialmente los signos de actividad de la enfermedad, como la hiperpermeabilidad coroidea o el desprendimiento de retina neurosensorial. La mejoría en la agudeza visual, sin embargo, no es constante, probablemente debido a la alteración en el EPR. Objective: To determine the efficacy of Photodynamic Therapy (PDT) in chronic Central Serous Chorioretinopathy (CSC). Methods: Patients diagnosed with chronic CSC, with clinical evidence of activity and treated with Photodynamic Therapy, are included in this report. All were assessed by a complete ophthalmological examination, including assessment of the best corrected visual acuity (BCVA) using an ETDRS chart, fluorescein and indocyanine angiography and optical coherence tomography (OCT). The main objective of the study was to determine the mean visual acuity change. Results: 11 eyes of 11 patients were included in the study, which had a mean follow-up period of 11 months. The mean BCVA increased from 20/76 to 20/64. 35% of eyes improved their BCVA by 2 lines or more, 45% remained stable and 18% lost 2 lines or more. Choroidal hyperpermeability was reduced in every case. Neurosensorial retinal detachment decreased in 80% of cases. Only one eye received a second PDT treatment due to choroidal neovascularization. An increase of atrophy over the Retinal Pigment Epithelium (RPE) was observed in another patient. Conclusions: PDT can reduce the clinical signs of activity, such as choroidal hyperpermeability or neurosensorial retinal detachment, in patients affected by chronic CSC. However, the increase in visual acuity is variable, probably due to the extent of RPE damage.
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- 2008
15. Terapia fotodinámica en estrías angioides
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Elías-de-Tejada, M., Calvo-González, C., Reche-Frutos, J., Donate-López, J., and García-Sánchez, J.
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Estrías angioides ,Angioid streaks ,photodynamic therapy ,neovascularización coroidea ,terapia fotodinámica ,choroidal neovascularization - Abstract
Objetivo: Evaluar la eficacia y seguridad de la Terapia Fotodinámica (TFD) en la neovascularización coroidea (NVC) asociada a estrías angioides (EA). Métodos: Se realiza un estudio retrospectivo de ocho pacientes (once ojos) diagnosticados de EA, que presentan neovascularización subfoveal, yuxtafoveal o extrafoveal, tratada al menos una vez con TFD. Se obtiene la mejor agudeza visual corregida (MAVC), retinografía así como angiografía con fluoresceína (AFG), antes y después del tratamiento para valorar su eficacia. El seguimiento medio fue de 13,2 meses. Resultados: Diez ojos presentaban membranas subfoveales, un ojo yuxtafoveal y otro extrafoveal. Tras la TFD, la AV se mantuvo igual en dos pacientes, aumentó en un paciente y disminuyó en ocho pacientes. En cuanto a la respuesta angiográfica, nueve ojos presentaron respuesta fibrótica tras una sesión de TFD, mientras que en dos ojos persistió exudación. Hubo tres casos de recidiva de la NVC. Conclusiones: La TFD en la NVC asociada a EA no parece alterar el curso de esta enfermedad, sólo enlentece su progresión. Objetive: To evaluate the efficacy and safety of photodynamic therapy in choroidal neovascularization associated with angioid streaks. Methods: We performed a retrospective study of eleven eyes (eight patients) with subfoveal, juxtafoveal or extrafoveal neovascularization, which received at least one session of photodynamic therapy. Treatment efficacy was evaluated by visual acuity (VA) testing, color photography and fluorescein angiography. The mean follow-up was 13.2 months. Results: Ten eyes presented subfoveal neovascularization, one eye presented juxtafoveal and another eye extrafoveal neovascularization. VA was unchanged in two patients, increased in one patient, and decreased in eight patients following photodynamic therapy. Nine eyes presented conversion to a fibrotic disciform lesion, whereas leakage persisted in two eyes after one session of photodynamic therapy. Recurrence of choroidal neovascularization appeared in three eyes. Conclusions: Photodynamic therapy in choroidal neovascularization related to angioid streaks does not appear to alter the course of this disease, but it does slow its progression.
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- 2007
16. Bilateral papilledema secondary to chronic lymphocytic leukaemia
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Sáenz-Francés, F., Calvo-González, C., Reche-Frutos, J., Donate-López, J., Huelga-Zapico, E., García-Sánchez, J., and García-Feijoó, J.
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leucemia linfática crónica ,Chronic lymphocytic leukaemia ,genetic structures ,Leucemia linfocítica crónica ,papiledema ,leukaemic infiltration ,infiltración leucémica ,papilledema ,nervio óptico ,eye diseases ,optic nerve - Abstract
Caso clínico: Varón de 65 que consulta por pérdida de agudeza visual bilateral. Había sido diagnosticado de leucemia linfocítica crónica hacía 2 años y se encontraba sin tratamiento. Su agudeza visual era de 20/200 en el ojo derecho y 20/63 en el izquierdo y presentaba edema bilateral de papila. Se realizaron tomografía axial computerizada y resonancia magnética orbital y cerebral encontrándose una masa orbitaria con extensión al etmoides e infiltración de ambos nervios ópticos cuya biopsia reveló leucemia linfocítica crónica. Discusión: La infiltración leucémica del nervio óptico y del sistema nervioso central es extremadamente rara en la leucemia linfocítica crónica al contrario de lo que sucede en las formas agudas. La infiltración del nervio óptico es la manifestación oftalmológica leucémica que implica mayor trascendencia clínica y terapéutica por amenazar seriamente la función visual y ser tratable. Case report: We present the case of a 65-year-old man who was seen in the casualty department complaining of bilateral visual loss. His past medical history was unremarkable except for chronic lymphocytic leukaemia diagnosed two years previously: he was no longer receiving treatment for this disorder. His visual acuity was 20/200 in the right eye and 20/63 in the left eye and he had a bilateral papilledema. Computed tomography and magnetic resonance imaging of the brain and orbit were performed and showed an infiltrative mass in the orbit with extension to the ethmoid bone and both optic nerves. Biopsy of the mass was compatible with chronic lymphocytic leukaemia. Discussion: Leukaemic infiltration of the optic nerve and central nervous system is a rare complication of chronic lymphocytic leukaemia, although it is common in the acute forms of this disease. Optic nerve infiltration is the most important ophthalmologic manifestation of leukaemia because it threatens vision and it is treatable.
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- 2007
17. Edema bilateral del nervio óptico por leucemia linfocítica crónica
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Juan Donate-Lopez, Reche-Frutos J, García-Feijoó J, García-Sánchez J, Calvo-González C, Sáenz-Francés F, and Huelga-Zapico E
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leucemia linfática crónica ,Lymphocytic leukaemia ,Leukaemic infiltration ,Visual acuity ,genetic structures ,business.industry ,papiledema ,Ethmoid bone ,nervio óptico ,eye diseases ,Agudeza visual ,Ophthalmology ,Left eye ,Leucemia linfocítica crónica ,Optic nerve ,Medicine ,infiltración leucémica ,Bilateral papilledema ,medicine.symptom ,business ,Nuclear medicine - Abstract
espanolCaso clinico: Varon de 65 que consulta por perdida de agudeza visual bilateral. Habia sido diagnosticado de leucemia linfocitica cronica hacia 2 anos y se encontraba sin tratamiento. Su agudeza visual era de 20/200 en el ojo derecho y 20/63 en el izquierdo y presentaba edema bilateral de papila. Se realizaron tomografia axial computerizada y resonancia magnetica orbital y cerebral encontrandose una masa orbitaria con extension al etmoides e infiltracion de ambos nervios opticos cuya biopsia revelo leucemia linfocitica cronica. Discusion: La infiltracion leucemica del nervio optico y del sistema nervioso central es extremadamente rara en la leucemia linfocitica cronica al contrario de lo que sucede en las formas agudas. La infiltracion del nervio optico es la manifestacion oftalmologica leucemica que implica mayor trascendencia clinica y terapeutica por amenazar seriamente la funcion visual y ser tratable. EnglishCase report: We present the case of a 65-year-old man who was seen in the casualty department complaining of bilateral visual loss. His past medical history was unremarkable except for chronic lymphocytic leukaemia diagnosed two years previously: he was no longer receiving treatment for this disorder. His visual acuity was 20/200 in the right eye and 20/63 in the left eye and he had a bilateral papilledema. Computed tomography and magnetic resonance imaging of the brain and orbit were performed and showed an infiltrative mass in the orbit with extension to the ethmoid bone and both optic nerves. Biopsy of the mass was compatible with chronic lymphocytic leukaemia. Discussion: Leukaemic infiltration of the optic nerve and central nervous system is a rare complication of chronic lymphocytic leukaemia, although it is common in the acute forms of this disease. Optic nerve infiltration is the most important ophthalmologic manifestation of leukaemia because it threatens vision and it is treatable.
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- 2007
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18. Drusas del nervio óptico y defectos campimétricos severos
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Calvo-González, C., Santos-Bueso, E., Díaz-Valle, D., Reche-Frutos, J., Moriche-Carretero, M., Benítez-Del-Castillo, J.M., and García-Sánchez, J.
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sonography ,defectos campimétricos ,campimetric defects ,Drusas nervio óptico ,Optic nerve drusen ,ecografía - Abstract
Objetivo: Las drusas del nervio óptico deben ser incluidas en el diagnóstico diferencial de pseudopapiledema, ya que pueden resultar difícilmente identificables mediante funduscopia. Por ello se hace necesaria la utilización de la ecografía, como gold standard en su diagnóstico. Se ha correlacionado la severidad de las drusas papilares con la reducción del espesor de la capa de fibras nerviosas medidas por tomografía óptica de coherencia y con la existencia de defectos importantes en el campo visual. Demostrar la existencia de una alteración campimétrica asociada a la presencia de drusas del nervio óptico extensas. Métodos: Estudio descriptivo prospectivo de campimetrías realizadas por una serie de 5 pacientes afectos de drusas del nervio óptico severas diagnosticadas mediante ultrasonografía. Resultados: Se han observado defectos campimétricos destacables de diversa severidad en todos los pacientes estudiados, que oscilan entre escalón nasal y defectos de hemicampos severos. Conclusiones: Los pacientes afectos de drusas papilares profundas presentan con frecuencia alteraciones en su campo visual de profundidad variable, por lo que los autores recomiendan un seguimiento campimétrico y/o con tomografía de coherencia óptica en estos casos. Purpose: Optic nerve drusen needs to be included in the differential diagnosis of pseudopapilledema. As the identification of this entity by funduscopy may be difficult, ultrasonography has thus become the gold standard for its diagnosis. Severe optic nerve drusen has been correlated with a reduction of the nerve fiber layer measured by optic coherence tomography and with the presence of serious visual field defects. To demonstrate the relationship between extensive optic nerve drusen and visual field defects. Method: A prospective observational study of the visual fields of a series of 5 patients with severe optic nerve drusen diagnosed by ultrasonography. Results: Visual field defects of widely differing severity, from inferior nasal quadrant to severe hemivisual field defects, were described in each patient studied. Conclusions: Visual field defects of diverse severity are common in patients with deep optic nerve drusen. For that reason ultrasonography and/or optical coherence tomography is highly recommended where such visual field defects exist.
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- 2006
19. Tomografía de coherencia óptica en la retinopatía por eclipse
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Calvo-González, C., Reche-Frutos, J., Santos-Bueso, E., Díaz-Valle, D., Benítez-Del-Castillo, J.M., and García-Sánchez, J.
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Retinopatía solar ,optical coherence tomography ,Solar retinopathy ,tomografía coherencia óptica - Abstract
Caso clínico: Se describe el caso de un paciente que sufrió pérdida visual aguda tras visualización directa y mantenida de un eclipse solar. El diagnóstico se realiza principalmente mediante tomografía de coherencia óptica. Discusión: La retinopatía solar es actualmente una causa poco frecuente de pérdida visual. No obstante, se describen algunos casos, especialmente tras la visualización de eclipses de sol. La tomografía de coherencia óptica constituye una prueba diagnóstica adecuada para detectar alteraciones, de forma característica, en las capas más externas de la retina, secundarias a la exposición solar constante. Case report: We describe the case of a patient suffering from acute visual loss soon after watching a solar eclipse. Optical coherence tomography was the main diagnostic tool used. Discussion: Solar retinopathy is now an unusual cause of visual loss, although there are still some cases diagnosed, especially after viewing solar eclipses. Optical coherence tomography is suitable for detecting permanent retinal injuries related to solar exposure, with the outer retinal layers being typically affected.
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- 2006
20. Intravitreal ranibizumab (Lucentis®) in the treatment of choroidal neovascular membrane secondary to punctate inner choroidopathy
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Valverde Megías, A., Arriola Villalobos, P., Reche Frutos, J., Donate López, J., Calvo González, C., and García Feijoo, J.
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- 2010
- Full Text
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21. Concordancia entre la tonometría de aplanación de Goldmann y la tonometría de contorno dinámico: efectos de la morfometría corneal
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Sáenz-Francés, F., primary, García-Catalán, R., additional, Jerez-Fidalgo, M., additional, Fernández-Vidal, A., additional, Martínez-de-la-Casa, J.M., additional, Méndez-Hernández, C., additional, Santos-Bueso, E., additional, Reche-Frutos, J., additional, García-Sánchez, J., additional, and García-Feijoo, J., additional
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- 2011
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22. Ranibizumab (Lucentis®) intravítreo en el tratamiento de membrana neovascular coroidea secundaria a coroidopatía punctata interna
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Valverde Megías, A., primary, Arriola Villalobos, P., additional, Reche Frutos, J., additional, Donate López, J., additional, Calvo González, C., additional, and García Feijoo, J., additional
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- 2010
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- View/download PDF
23. Metástasis coroideas de carcinoma de mama: Diagnóstico y seguimiento mediante tomografía de coherencia óptica y angiofluoresceingrafía y autofluorescencia con HRA-II (Heidelberg Retina Angiograph)
- Author
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Pérez-Álvarez, M.J., primary, Arriola-Villalobos, P., additional, Reche-Frutos, J., additional, and García-Sánchez, J., additional
- Published
- 2009
- Full Text
- View/download PDF
24. Terapia fotodinámica en coriorretinopatía serosa central crónica severa
- Author
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Reche-Frutos, J., primary, Calvo-González, C., additional, Donate-López, J., additional, Sáenz-Francés-San-Baldomero, F., additional, Cerván-López, I., additional, García-Feijoó, J., additional, and García-Sánchez, J., additional
- Published
- 2008
- Full Text
- View/download PDF
25. Combined Pegaptanib sodium (Macugen) and photodynamic therapy in predominantly classic juxtafoveal choroidal neovascularisation in age related macular degeneration
- Author
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Calvo-Gonzalez, C, primary, Reche-Frutos, J, additional, Donate-Lopez, J, additional, Garcia-Feijoo, J, additional, Leila, M, additional, Fernandez-Perez, C, additional, and Garcia-Sanchez, J, additional
- Published
- 2007
- Full Text
- View/download PDF
26. Terapia fotodinámica en estrías angioides
- Author
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Elías-de-Tejada, M., primary, Calvo-González, C., additional, Reche-Frutos, J., additional, Donate-López, J., additional, and García-Sánchez, J., additional
- Published
- 2007
- Full Text
- View/download PDF
27. Photodynamic therapy in non-subfoveal choroidal neovascularization secondary to pathological myopia: 1-year outcome
- Author
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Reche-Frutos, J., primary, Calvo-Gonzalez, C., additional, Donate-Lopez, J., additional, Garcia-Feijoo, J., additional, Wasfy, M, additional, Saenz-Frances, F, additional, Fernandez-Perez, C, additional, and Garcia-Sanchez, J, additional
- Published
- 2007
- Full Text
- View/download PDF
28. Edema bilateral del nervio óptico por leucemia linfocítica crónica
- Author
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Sáenz-Francés, F., primary, Calvo-González, C., additional, Reche-Frutos, J., additional, Donate-López, J., additional, Huelga-Zapico, E., additional, García-Sánchez, J., additional, and García-Feijoó, J., additional
- Published
- 2007
- Full Text
- View/download PDF
29. Tomografía de coherencia óptica en la retinopatía por eclipse
- Author
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Calvo-González, C., primary, Reche-Frutos, J., additional, Santos-Bueso, E., additional, Díaz-Valle, D., additional, Benítez-Del-Castillo, J.M., additional, and García-Sánchez, J., additional
- Published
- 2006
- Full Text
- View/download PDF
30. Drusas del nervio óptico y defectos campimétricos severos
- Author
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Calvo-González, C., primary, Santos-Bueso, E., additional, Díaz-Valle, D., additional, Reche-Frutos, J., additional, Moriche-Carretero, M., additional, Benítez-Del-Castillo, J.M., additional, and García-Sánchez, J., additional
- Published
- 2006
- Full Text
- View/download PDF
31. Bilateral papilledema secondary to chronic lymphocytic leukaemia,Edema bilateral del nervio óptico por leucemia linfocítica crónica
- Author
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Federico Saenz-Frances, Calvo-González, C., Reche-Frutos, J., Donate-López, J., Huelga-Zapico, E., García-Sánchez, J., and García-Feijoó, J.
32. Photodynamic therapy in severe chronic central serous chorioretinopaty,Terapia fotodinámica en coriorretinopatía serosa central crónica severa
- Author
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Reche-Frutos, J., Calvo-González, C., JUAN DONATE, Sáenz-Francés-San-Baldomero, F., Cerván-López, I., García-Feijoó, J., and García-Sánchez, J.
33. Indocyanine green angiography findings in patients with neovascular age-related macular degeneration refractory to ranibizumab switched to aflibercept.
- Author
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Calvo-Gonzalez C, Reche-Frutos J, Fernández-Vigo JI, Donate-López J, Serrano-García I, and Fernández-Pérez C
- Subjects
- Aged, Angiogenesis Inhibitors administration & dosage, Coloring Agents pharmacology, Drug Substitution, Female, Follow-Up Studies, Fundus Oculi, Humans, Intravitreal Injections, Male, Prospective Studies, Vascular Endothelial Growth Factor A antagonists & inhibitors, Wet Macular Degeneration drug therapy, Fluorescein Angiography methods, Indocyanine Green pharmacology, Macula Lutea pathology, Ranibizumab administration & dosage, Receptors, Vascular Endothelial Growth Factor administration & dosage, Recombinant Fusion Proteins administration & dosage, Visual Acuity, Wet Macular Degeneration diagnosis
- Abstract
Purpose: To describe indocyanine green angiography (ICGA) and visual acuity (VA) results in patients with neovascular age-related macular degeneration (nAMD) refractory to ranibizumab switched to aflibercept., Methods: This study is a prospective interventional case series. Thirty-two eyes of 32 patients with nAMD showing a poor response after at least 24 months of ranibizumab were switched to aflibercept. Twenty eyes had type I choroidal neovascularization (CNV group), and 12 eyes had polypoidal choroidal vasculopathy (PCV group). After an initial loading dose of three monthly aflibercept injections, treatment was continued on a treat-and-extend basis. ICGA was performed just before the first aflibercept injection (baseline) and 12 and 24 months later. The variables recorded were: closure of polyps and lesion area, VA, number of aflibercept injections, dry macula, and pigment epithelium detachment., Results: The following means were recorded in the CNV and PCV groups, respectively: number of ranibizumab injections 20.4 ± 11.2 and 22.4 ± 12.9 (p = 0.740); baseline VA (before aflibercept) 73.2 ± 9.1 and 70.3 ± 13.7 letters (p = 0.654); and final VA 73.0 ± 7.6 and 69.3 ± 15.6 letters (p = 0.509). VA remained stable (p = 0.761 and 0.964) after 15.5 ± 3 and 15.1 ± 3.5 aflibercept injections (p = 0.244). At 24 months, dry macula was noted in 40 to 50% of the eyes (p = 0.620). Complete resolution of polyps was observed in 58% at 12 months and 92% at 24 months., Conclusions: In patients with nAMD refractory to ranibizumab, aflibercept was effective at maintaining VA and closing numerous polyps. In half of the patients, dry macula was observed at 24 months.
- Published
- 2019
- Full Text
- View/download PDF
34. Long-Term Outcomes of Two Different Initial Dosing Regimens of Intravitreal Ranibizumab Used to Treat Myopic Choroidal Neovascularization.
- Author
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Calvo-González C, Reche-Frutos J, Fernández-Vigo JI, Sáenz-Francés F, Fernández-Pérez C, and García-Feijóo J
- Subjects
- Adult, Aged, Aged, 80 and over, Angiogenesis Inhibitors administration & dosage, Choroidal Neovascularization diagnosis, Choroidal Neovascularization etiology, Dose-Response Relationship, Drug, Female, Follow-Up Studies, Humans, Intravitreal Injections, Male, Middle Aged, Myopia, Degenerative diagnosis, Retina pathology, Retrospective Studies, Time Factors, Tomography, Optical Coherence, Treatment Outcome, Young Adult, Choroidal Neovascularization drug therapy, Myopia, Degenerative complications, Ranibizumab administration & dosage, Visual Acuity
- Abstract
Purpose: To compare two different initial dosing regimens of intravitreal ranibizumab used to treat myopic choroidal neovascularization., Methods: A total of 61 eyes of 56 patients were treated: 26 eyes received a single injection followed by treatment pro re nata (1+ PRN), while 35 eyes first received 3 consecutive monthly injections (3+ PRN)., Results: The mean follow-up was 53 ± 16 months. The visual acuities were 51.9 ± 16.2 letters with 3+ PRN and 53 ± 22.4 letters with 1+ PRN at baseline (p = 0.824); 69.5 ± 12.3 and 69 ± 15.1 letters, respectively, at 12 months; and 67.1 ± 16.2 and 66.4 ± 19.7 letters, respectively, at the end of follow-up (p = 0.877). Mean survival until first retreatment after the loading dose was 36.9 ± 6.1 months with 3+ PRN and 19.2 ± 5.4 months with 1+ PRN (p < 0.001)., Conclusions: Both dosing regimens led to similar visual outcomes. For eyes given a single injection in the first quarter, retreatment was needed appreciably earlier., (© 2017 S. Karger AG, Basel.)
- Published
- 2017
- Full Text
- View/download PDF
35. Retinal nerve fiber layer thickness changes in patients with age-related macular degeneration treated with intravitreal ranibizumab.
- Author
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Martinez-de-la-Casa JM, Ruiz-Calvo A, Saenz-Frances F, Reche-Frutos J, Calvo-Gonzalez C, Donate-Lopez J, and Garcia-Feijoo J
- Subjects
- Aged, Aged, 80 and over, Cohort Studies, Female, Fourier Analysis, Humans, Intraocular Pressure drug effects, Intravitreal Injections, Macular Degeneration pathology, Macular Degeneration physiopathology, Male, Middle Aged, Nerve Fibers pathology, Prospective Studies, Ranibizumab, Retina pathology, Tomography, Optical Coherence methods, Angiogenesis Inhibitors administration & dosage, Antibodies, Monoclonal, Humanized administration & dosage, Macular Degeneration drug therapy, Nerve Fibers drug effects, Retina drug effects
- Abstract
Purpose: To assess the effects of intravitreal ranibizumab therapy on intraocular pressure (IOP) and retinal nerve fiber (RNFL) thickness., Methods: Forty-nine eyes of 49 patients with neovascular age-related macular degeneration (AMD) treated with intravitreal ranibizumab injections and 27 fellow eyes not requiring treatment were followed for 1 year. RNFL thickness, as measured by Fourier domain optical coherence tomography, and IOP were determined pre- and postinjection., Results: After 12 months, the mean number of injections received was 4.8 ± 1.6. The incidence of IOP elevations (>5 mm Hg over baseline) observed at the time of injection was 0.4%. Baseline RNFL thickness was 105.7 ± 12.2 μm in the treatment group compared with 101.8 ± 11.6 μm in the control group (P = 0.176). At the end of follow-up, significant RNFL thinning was noted in the treatment group (100.2 ± 11.0 μm, P < 0.001), whereas no differences were found in the control group (100.5 ± 10.8 μm, P = 0.477)., Conclusions: Intravitreal ranibizumab injections used to treat AMD caused a significant change in RNFL thickness after 12 months of follow-up.
- Published
- 2012
- Full Text
- View/download PDF
36. Ranibizumab in retinal angiomatous proliferation (RAP): influence of RAP stage on visual outcome.
- Author
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Reche-Frutos J, Calvo-Gonzalez C, Pérez-Trigo S, Fernandez-Perez C, Donate-Lopez J, and Garcia-Feijoo J
- Subjects
- Aged, 80 and over, Angiogenesis Inhibitors therapeutic use, Antibodies, Monoclonal, Humanized therapeutic use, Female, Fluorescein Angiography, Humans, Indocyanine Green, Intravitreal Injections, Macular Degeneration classification, Macular Degeneration physiopathology, Male, Prospective Studies, Ranibizumab, Retinal Neovascularization classification, Retinal Neovascularization physiopathology, Retreatment, Tomography, Optical Coherence, Treatment Outcome, Vascular Endothelial Growth Factor A antagonists & inhibitors, Angiogenesis Inhibitors administration & dosage, Antibodies, Monoclonal, Humanized administration & dosage, Macular Degeneration drug therapy, Retinal Neovascularization drug therapy, Visual Acuity physiology
- Abstract
Purpose: To evaluate the influence of retinal angiomatous proliferation (RAP) stage on visual and anatomic outcome after ranibizumab (Lucentis®)., Methods: This was a prospective study on consecutively diagnosed RAP eyes at the Hospital Clínico San Carlos, Madrid. Best-corrected visual acuity (BCVA) and optical coherence tomography (OCT) are performed monthly. Indocyanine green angiography (ICG) and fluorescein angiography (FA) are performed at baseline and every 3 months thereafter. A starting dose of a monthly ranibizumab injection in the first 3 months is followed by retreatment in case of intraretinal edema, subretinal fluid, or pigment epithelium detachment (PED) in OCT, increased leakage in FA, or a hot spot in ICG., Results: A total of 53 eyes from 49 patients were included. The mean change in BCVA at 12 months was +7.3, +0.83, and -2.1 letters in stages IIA (21 cases), II B (18 cases), and III (14 cases), respectively. After adjusting the change in BCVA according to baseline BCVA, ß coefficient was -6.012 letters (p=0.025) in stage IIB and -9.762 letters (p=0.003) in stage III vs stage IIA. Four cases had a retinal pigment epithelium tear after injection of ranibizumab., Conclusions: Patients in stage II without PED have a better visual and anatomic evolution than patients in stage II with PED and stage III.
- Published
- 2011
- Full Text
- View/download PDF
37. Comparing corneal variables in healthy subjects and patients with primary open-angle glaucoma.
- Author
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Saenz-Frances F, Garcia-Feijó J, Jañez L, Borrego-Sanz L, Martinez de la Casa JM, Fernandez-Vidal A, Mendez-Hernández C, Santos-Bueso E, Reche-Frutos J, and Garcia-Sánchez J
- Subjects
- Anthropometry, Area Under Curve, Cornea diagnostic imaging, Cross-Sectional Studies, Gonioscopy, Humans, ROC Curve, Ultrasonography, Visual Fields, Cornea pathology, Glaucoma, Open-Angle diagnosis
- Abstract
Purpose: This study was designed to identify possible differences between healthy subjects and patients with primary open-angle glaucoma (POAG) in keratometry, central corneal thickness, overall corneal thickness, mean thickness of a circular zone centered at the corneal apex of 1-mm radius (zone I), and mean thickness of several concentric rings also centered at the apex of 1-mm width (zones II to VI, respectively)., Methods: These variables were recorded in 126 healthy subjects and 130 patients with POAG. Corneal thicknesses and the power of the flattest and steepest axes were compared between the two populations using a t-test and the position of the flattest axis using a Mann-Whitney U test. A binary logistic regression procedure was used to determine the diagnostic capacity of the corneal variables using the area under the receiver operator characteristic curve (AUC) to select the best regression equation., Results: Significant differences between subjects and patients were detected in mean corneal thickness and in mean thicknesses of zones I to VI. The logistic regression model included as predictors the mean corneal thickness and the mean thicknesses of zones IV and VI; for this model, the AUC was 0.711, sensitivity was 67.7%, and specificity was 65.5%., Conclusions: Healthy subjects and glaucoma patients differ significantly in terms of mean overall corneal thickness and thicknesses of the corneal zones I to VI defined here. The variables mean corneal thickness and mean thicknesses of zones IV and VI are able to discriminate between subjects with or without glaucoma.
- Published
- 2011
- Full Text
- View/download PDF
38. Intravitreal ranibizumab for myopic choroidal neovascularization: factors predictive of visual outcome and need for retreatment.
- Author
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Calvo-Gonzalez C, Reche-Frutos J, Donate J, Fernandez-Perez C, and Garcia-Feijoo J
- Subjects
- Antibodies, Monoclonal, Humanized, Choroidal Neovascularization diagnosis, Choroidal Neovascularization physiopathology, Female, Fluorescein Angiography, Follow-Up Studies, Humans, Intravitreal Injections, Macula Lutea pathology, Male, Middle Aged, Myopia diagnosis, Myopia physiopathology, Prospective Studies, Ranibizumab, Retreatment, Risk Factors, Tomography, Optical Coherence, Treatment Outcome, Antibodies, Monoclonal therapeutic use, Choroidal Neovascularization drug therapy, Myopia drug therapy, Visual Acuity physiology
- Abstract
Purpose: To identify predictive factors for visual outcome and need for retreatment after treating myopic choroidal neovascularization (CNV) with ranibizumab., Design: A prospective interventional case series., Methods: Sixty-seven eyes of 67 patients with myopic CNV were treated with 3 intravitreal ranibizumab injections given monthly. Best-corrected visual acuity (BCVA) and optical coherence tomography-determined central macular thickness (CMT) were recorded monthly during follow-up. Fluorescein angiography changes and the number of injections needed were also assessed., Results: Mean follow-up was 15.9 months. Mean BCVA improved by 7.8 letters after the first injection, 12.5 letters after 3 injections, and 12 letters by end follow-up. In 53 eyes (79.1%), BCVA improved; 40.3% gained more than 15 letters. No differences were detected in visual outcome between treatment-naïve and previously treated patients. Myopic CNV area and greatest linear dimension had diminished at the study end. The mean reduction in CMT was 93.6 μm. The mean number of injections given was 4.2. A total of 53.7% of eyes received only 3 injections. Through regression analysis, baseline BCVA (P = .006) and myopic CNV location (P = .026) were significantly correlated with BCVA at the end of follow-up. Myopic CNV location (P = .023) and prior treatment (P = .047) were significantly linked to the number of injections given. No major complications arose., Conclusion: An initial treatment regimen of 3 monthly ranibizumab injections seems effective and safe to treat myopic CNV. Baseline BCVA and myopic CNV location emerged as predictive factors for visual outcome. A need for retreatment was associated with myopic CNV location and prior treatment., (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Published
- 2011
- Full Text
- View/download PDF
39. Early neovascular bridging of choroidal neovascularization after ranibizumab treatment.
- Author
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Reche-Frutos J, Calvo-Gonzalez C, Donate-Lopez J, and Garcia-Feijoo J
- Subjects
- Adult, Aged, Antibodies, Monoclonal administration & dosage, Antibodies, Monoclonal, Humanized, Choroidal Neovascularization diagnosis, Choroidal Neovascularization etiology, Choroidal Neovascularization physiopathology, Disease Progression, Drug Administration Schedule, Female, Fluorescein Angiography, Follow-Up Studies, Fovea Centralis pathology, Fundus Oculi, Humans, Injections, Male, Ophthalmoscopy, Ranibizumab, Visual Acuity drug effects, Antibodies, Monoclonal adverse effects, Choroidal Neovascularization drug therapy, Choroiditis complications, Macular Degeneration complications, Myopia, Degenerative complications
- Abstract
Background: To report three cases of early choroidal neovascularization (CNV) bridging after ranibizumab treatment., Methods: Three patients with two separated foci of CNV secondary to age-related macular degeneration (ARMD), pathologic myopia and multifocal choroiditis were treated with monthly injections of ranibizumab por a period of 3 months., Results: All three cases showed early coalescence across the fovea of the two neovascular foci, already 1 month after the first ranibizumab injection. Best-corrected visual acuity (BCVA) decreased in the three cases more than 20 letters due to early foveal involvement., Conclusions: Two different foci of CNV show a great tendency to decrease patients' vision because of neovascular bridging with foveal implication.
- Published
- 2009
- Full Text
- View/download PDF
40. Intravitreal pegabtanib sodium in choroidal neovascularization secondary to angioid streaks.
- Author
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Molina Guilabert I, Calvo-González C, Reche-Frutos J, Donate-López J, García-Feijoó J, Leila M, and García-Sánchez J
- Subjects
- Adult, Edema complications, Edema diagnosis, Fluorescein Angiography, Humans, Injections, Male, Retinal Detachment complications, Retinal Detachment diagnosis, Retinal Diseases complications, Retinal Diseases diagnosis, Tomography, Optical Coherence, Vitreous Body, Angiogenesis Inhibitors administration & dosage, Angioid Streaks complications, Aptamers, Nucleotide administration & dosage, Choroidal Neovascularization drug therapy, Choroidal Neovascularization etiology
- Published
- 2009
- Full Text
- View/download PDF
41. [Choroidal metastasis from a breast carcinoma. Diagnosis and follow-up with optical coherence tomography and fluorescein angiography and autofluorescence with HRA-II (Heidelberg Retina Angiograph)].
- Author
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Pérez-Alvarez MJ, Arriola-Villalobos P, Reche-Frutos J, and García-Sánchez J
- Subjects
- Aged, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Breast Neoplasms drug therapy, Breast Neoplasms surgery, Carcinoma, Ductal, Breast complications, Carcinoma, Ductal, Breast diagnosis, Carcinoma, Ductal, Breast drug therapy, Carcinoma, Ductal, Breast radiotherapy, Choroid Neoplasms complications, Choroid Neoplasms diagnosis, Choroid Neoplasms drug therapy, Choroid Neoplasms radiotherapy, Combined Modality Therapy, Cyclophosphamide administration & dosage, Cyclophosphamide analogs & derivatives, Doxorubicin administration & dosage, Female, Fluorescein Angiography, Fluorouracil administration & dosage, Humans, Lymph Node Excision, Mastectomy, Radical, Optic Nerve Neoplasms secondary, Palliative Care, Retinal Detachment etiology, Tomography, Optical Coherence, Breast Neoplasms pathology, Carcinoma, Ductal, Breast secondary, Choroid Neoplasms secondary
- Abstract
Clinical Case: A 69-year-old woman developed choroidal metastasis from a breast carcinoma 2 years after the initial diagnosis, surgery and chemotherapy. After treatment with palliative chemotherapy and external radiotherapy, we used fluorescein angiography (FA) and optical coherence tomography (OCT) to evaluate the resolution of the serous retinal detachment, as well as a later relapse in the optic nerve., Discussion: OCT is useful in the follow-up of choroidal metastasis after treatment. However, OCT imaging is limited by the initial choroidal location of metastasis. The autofluorescence can detect exudative tumoral activity even without obvious changes in OCT or FA.
- Published
- 2009
- Full Text
- View/download PDF
42. Intravitreal bevacizumab (Avastin) for radiation retinopathy neovascularization.
- Author
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Arriola-Villalobos P, Donate-López J, Calvo-González C, Reche-Frutos J, Alejandre-Alba N, and Díaz-Valle D
- Subjects
- Adult, Angiogenesis Inhibitors administration & dosage, Antibodies, Monoclonal administration & dosage, Antibodies, Monoclonal, Humanized, Bevacizumab, Humans, Injections, Male, Retinal Neovascularization etiology, Vitreous Body, Angiogenesis Inhibitors therapeutic use, Antibodies, Monoclonal therapeutic use, Carcinoma, Adenoid Cystic radiotherapy, Maxillary Sinus Neoplasms radiotherapy, Radiation Injuries complications, Retinal Neovascularization drug therapy
- Published
- 2008
- Full Text
- View/download PDF
43. [Photodynamic therapy in severe chronic central serous chorioretinopaty].
- Author
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Reche-Frutos J, Calvo-González C, Donate-López J, Sáenz-Francés-San-Baldomero F, Cerván-López I, García-Feijoó J, and García-Sánchez J
- Subjects
- Adult, Choroid Diseases complications, Chronic Disease, Female, Humans, Male, Middle Aged, Retinal Diseases complications, Severity of Illness Index, Choroid Diseases drug therapy, Photochemotherapy, Retinal Diseases drug therapy
- Abstract
Objective: To determine the efficacy of Photodynamic Therapy (PDT) in chronic Central Serous Chorioretinopathy (CSC)., Methods: Patients diagnosed with chronic CSC, with clinical evidence of activity and treated with Photodynamic Therapy, are included in this report. All were assessed by a complete ophthalmological examination, including assessment of the best corrected visual acuity (BCVA) using an ETDRS chart, fluorescein and indocyanine angiography and optical coherence tomography (OCT). The main objective of the study was to determine the mean visual acuity change., Results: 11 eyes of 11 patients were included in the study, which had a mean follow-up period of 11 months. The mean BCVA increased from 20/76 to 20/64. 35% of eyes improved their BCVA by 2 lines or more, 45% remained stable and 18% lost 2 lines or more. Choroidal hyperpermeability was reduced in every case. Neurosensorial retinal detachment decreased in 80% of cases. Only one eye received a second PDT treatment due to choroidal neovascularization. An increase of atrophy over the Retinal Pigment Epithelium (RPE) was observed in another patient., Conclusions: PDT can reduce the clinical signs of activity, such as choroidal hyperpermeability or neurosensorial retinal detachment, in patients affected by chronic CSC. However, the increase in visual acuity is variable, probably due to the extent of RPE damage.
- Published
- 2008
- Full Text
- View/download PDF
44. [Photodynamic therapy in angioid streaks].
- Author
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Elías-de-Tejada M, Calvo-González C, Reche-Frutos J, Donate-López J, and García-Sánchez J
- Subjects
- Aged, Female, Humans, Male, Middle Aged, Retrospective Studies, Choroidal Neovascularization therapy, Photochemotherapy
- Abstract
Objective: To evaluate the efficacy and safety of photodynamic therapy in choroidal neovascularization associated with angioid streaks., Methods: We performed a retrospective study of eleven eyes (eight patients) with subfoveal, juxtafoveal or extrafoveal neovascularization, which received at least one session of photodynamic therapy. Treatment efficacy was evaluated by visual acuity (VA) testing, color photography and fluorescein angiography. The mean follow-up was 13.2 months., Results: Ten eyes presented subfoveal neovascularization, one eye presented juxtafoveal and another eye extrafoveal neovascularization. VA was unchanged in two patients, increased in one patient, and decreased in eight patients following photodynamic therapy. Nine eyes presented conversion to a fibrotic disciform lesion, whereas leakage persisted in two eyes after one session of photodynamic therapy. Recurrence of choroidal neovascularization appeared in three eyes., Conclusions: Photodynamic therapy in choroidal neovascularization related to angioid streaks does not appear to alter the course of this disease, but it does slow its progression.
- Published
- 2007
- Full Text
- View/download PDF
45. [Bilateral papilledema secondary to chronic lymphocytic leukaemia].
- Author
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Sáenz-Francés F, Calvo-González C, Reche-Frutos J, Donate-López J, Huelga-Zapico E, García-Sánchez J, and García-Feijoó J
- Subjects
- Aged, Humans, Leukemia, Lymphocytic, Chronic, B-Cell pathology, Leukemic Infiltration pathology, Male, Optic Disk pathology, Leukemia, Lymphocytic, Chronic, B-Cell complications, Papilledema etiology
- Abstract
Case Report: We present the case of a 65-year-old man who was seen in the casualty department complaining of bilateral visual loss. His past medical history was unremarkable except for chronic lymphocytic leukaemia diagnosed two years previously: he was no longer receiving treatment for this disorder. His visual acuity was 20/200 in the right eye and 20/63 in the left eye and he had a bilateral papilledema. Computed tomography and magnetic resonance imaging of the brain and orbit were performed and showed an infiltrative mass in the orbit with extension to the ethmoid bone and both optic nerves. Biopsy of the mass was compatible with chronic lymphocytic leukaemia., Discussion: Leukaemic infiltration of the optic nerve and central nervous system is a rare complication of chronic lymphocytic leukaemia, although it is common in the acute forms of this disease. Optic nerve infiltration is the most important ophthalmologic manifestation of leukaemia because it threatens vision and it is treatable.
- Published
- 2007
- Full Text
- View/download PDF
46. [Optical coherence tomography in solar eclipse retinopathy].
- Author
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Calvo-González C, Reche-Frutos J, Santos-Bueso E, Díaz-Valle D, Benítez-del-Castillo JM, and García-Sánchez J
- Subjects
- Adult, Humans, Male, Solar System, Retinal Diseases etiology, Sunlight adverse effects, Tomography, Optical Coherence
- Abstract
Case Report: We describe the case of a patient suffering from acute visual loss soon after watching a solar eclipse. Optical coherence tomography was the main diagnostic tool used., Discussion: Solar retinopathy is now an unusual cause of visual loss, although there are still some cases diagnosed, especially after viewing solar eclipses. Optical coherence tomography is suitable for detecting permanent retinal injuries related to solar exposure, with the outer retinal layers being typically affected.
- Published
- 2006
47. [Optic nerve drusen and deep visual fields defects].
- Author
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Calvo-González C, Santos-Bueso E, Díaz-Valle D, Reche-Frutos J, Moriche-Carretero M, Benítez-Del-Castillo JM, and García-Sánchez J
- Subjects
- Adult, Aged, Female, Humans, Male, Middle Aged, Prospective Studies, Severity of Illness Index, Ultrasonography, Optic Disk Drusen complications, Optic Disk Drusen diagnostic imaging, Vision Disorders complications, Visual Fields
- Abstract
Purpose: Optic nerve drusen needs to be included in the differential diagnosis of pseudopapilledema. As the identification of this entity by funduscopy may be difficult, ultrasonography has thus become the gold standard for its diagnosis. Severe optic nerve drusen has been correlated with a reduction of the nerve fiber layer measured by optic coherence tomography and with the presence of serious visual field defects. To demonstrate the relationship between extensive optic nerve drusen and visual field defects., Method: A prospective observational study of the visual fields of a series of 5 patients with severe optic nerve drusen diagnosed by ultrasonography., Results: Visual field defects of widely differing severity, from inferior nasal quadrant to severe hemivisual field defects, were described in each patient studied., Conclusions: Visual field defects of diverse severity are common in patients with deep optic nerve drusen. For that reason ultrasonography and/or optical coherence tomography is highly recommended where such visual field defects exist.
- Published
- 2006
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