1. Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations.
- Author
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Santiago RP, Figueiredo CVB, Fiuza LM, Yahouédéhou SCMA, Oliveira RM, Aleluia MM, Carvalho SP, Fonseca CA, Nascimento VML, Rocha LC, Guarda CC, and Gonçalves MS
- Subjects
- Adolescent, Biomarkers metabolism, Cell Proliferation, Child, Cholesterol metabolism, Cholesterol, LDL, Female, Genotype, Humans, Inflammation, Linkage Disequilibrium, Male, Pneumonia metabolism, Prognosis, Proteoglycans blood, Receptors, Transforming Growth Factor beta blood, Young Adult, Anemia, Sickle Cell blood, Anemia, Sickle Cell genetics, Haplotypes, Hemoglobins metabolism, Lipids chemistry, Polymorphism, Single Nucleotide, Proteoglycans genetics, Receptors, Transforming Growth Factor beta genetics
- Abstract
Individuals with sickle cell disease (SCD) present both chronic and acute inflammatory events. The TGF- β pathway is known to play a role in immune response, angiogenesis, inflammation, hematopoiesis, vascular inflammation, and cell proliferation. Polymorphisms in the transforming growth factor-beta receptor 3 ( TGFBR3 ) gene have been linked to several inflammatory diseases. This study investigated associations between two TGFBR3 haplotypes and classical laboratory parameters, as well as clinical manifestations, in SCD. We found that individuals with the GG haplotype presented higher levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides, non-HDL cholesterol, total proteins, and globulin than individuals with non-GG haplotypes. In addition, the GG haplotype was associated with a previous history of pneumonia. Individuals with the CGG haplotype presented increased plateletcrit, TC, LDL-C levels, and non-HDL cholesterol. The CCG haplotype was also associated with a previous history of pneumonia. Our findings suggest that individuals with the GG and CGG haplotypes of TGFBR3 present important alterations in lipid profile., Competing Interests: The authors declare that there is no conflict of interest regarding the publication of this paper., (Copyright © 2020 Rayra P. Santiago et al.)
- Published
- 2020
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