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20 results on '"Recalde, Alice"'

1. Functional Epicardial Conduction Disturbances Due to a SCN5A Variant Associated With Brugada Syndrome

Author

Renard, Estelle, Walton, Richard D., Benoist, David, Brette, Fabien, Bru-Mercier, Gilles, Chaigne, Sébastien, Charron, Sabine, Constantin, Marion, Douard, Matthieu, Dubes, Virginie, Guillot, Bastien, Hof, Thomas, Magat, Julie, Martinez, Marine E., Michel, Cindy, Pallares-Lupon, Néstor, Pasdois, Philippe, Récalde, Alice, Vaillant, Fanny, Sacher, Frédéric, Labrousse, Louis, Rogier, Julien, Kyndt, Florence, Baudic, Manon, Schott, Jean-Jacques, Barc, Julien, Probst, Vincent, Sarlandie, Marine, Marionneau, Céline, Ashton, Jesse L., Hocini, Mélèze, Haïssaguerre, Michel, and Bernus, Olivier

Published
2023
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2. Inhibition of EPAC1 signaling pathway alters atrial electrophysiology and prevents atrial fibrillation

Author

Guillot, Bastien, primary, Boileve, Arthur, additional, Walton, Richard, additional, Harfoush, Alexandre, additional, Conte, Caroline, additional, Sainte-Marie, Yannis, additional, Charron, Sabine, additional, Bernus, Olivier, additional, Recalde, Alice, additional, Sallé, Laurent, additional, Brette, Fabien, additional, and Lezoualc’h, Frank, additional

Published
2023
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3. Regional Differences in Ca2+ Signaling and Transverse-Tubules across Left Atrium from Adult Sheep

Author

Cros, Caroline, primary, Douard, Matthieu, additional, Chaigne, Sebastien, additional, Pasqualin, Come, additional, Bru-Mercier, Gilles, additional, Recalde, Alice, additional, Pascarel-Auclerc, Caroline, additional, Hof, Thomas, additional, Haïssaguerre, Michel, additional, Hocini, Meleze, additional, Jaïs, Pierre, additional, Bernus, Olivier, additional, and Brette, Fabien, additional

Published
2023
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5. Regional Differences in Ca 2+ Signaling and Transverse-Tubules across Left Atrium from Adult Sheep.

Author

Cros, Caroline, Douard, Matthieu, Chaigne, Sebastien, Pasqualin, Come, Bru-Mercier, Gilles, Recalde, Alice, Pascarel-Auclerc, Caroline, Hof, Thomas, Haïssaguerre, Michel, Hocini, Meleze, Jaïs, Pierre, Bernus, Olivier, and Brette, Fabien

Subjects
LEFT heart atrium, REGIONAL differences, PULMONARY veins, ENDOCARDIUM, ATRIAL fibrillation
Abstract

Cardiac excitation-contraction coupling can be different between regions of the heart. Little is known at the atria level, specifically in different regions of the left atrium. This is important given the role of cardiac myocytes from the pulmonary vein sleeves, which are responsible for ectopic activity during atrial fibrillation. In this study, we present a new method to isolate atrial cardiac myocytes from four different regions of the left atrium of a large animal model, sheep, highly relevant to humans. Using collagenase/protease we obtained calcium-tolerant atrial cardiac myocytes from the epicardium, endocardium, free wall and pulmonary vein regions. Calcium transients were slower (time to peak and time to decay) in free wall and pulmonary vein myocytes compared to the epicardium and endocardium. This is associated with lower t-tubule density. Overall, these results suggest regional differences in calcium transient and t-tubule density across left atria, which may play a major role in the genesis of atrial fibrillation. [ABSTRACT FROM AUTHOR]

Published
2023
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6. BH4 Increases nNOS Activity and Preserves Left Ventricular Function in Diabetes

Author

Carnicer, Ricardo, primary, Duglan, Drew, additional, Ziberna, Klemen, additional, Recalde, Alice, additional, Reilly, Svetlana, additional, Simon, Jillian N., additional, Mafrici, Simona, additional, Arya, Ritu, additional, Roselló-Lletí, Esther, additional, Chuaiphichai, Surawee, additional, Tyler, Damian, additional, Lygate, Craig A., additional, Channon, Keith M., additional, and Casadei, Barbara, additional

Published
2021
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10. Mutual Regulation of Epicardial Adipose Tissue and Myocardial Redox State by PPAR-gamma/Adiponectin Signalling

Author

Antonopoulos, Alexios S., Margaritis, Marios, Verheule, Sander, Recalde, Alice, Sanna, Fabio, Herdman, Laura, Psarros, Costas, Nasrallah, Hussein, Coutinho, Patricia, Akoumianakis, Ioannis, Brewer, Alison C., Sayeed, Rana, Krasopoulos, George, Petrou, Mario, Tarun, Akansha, Tousoulis, Dimitris, Shah, Ajay M., Casadei, Barbara, Channon, Keith M., Antoniades, Charalambos, RS: CARIM - R2.11 - Experimental atrial fibrillation, Fysiologie, and Promovendi CD

Subjects
obesity, adiponectin, myocardium, oxidative stress, adipose tissue
Abstract

Rationale: Adiponectin has anti-inflammatory effects in experimental models, but its role in the regulation of myocardial redox state in humans is unknown. Although adiponectin is released from epicardial adipose tissue (EpAT), it is unclear whether it exerts any paracrine effects on the human myocardium. Objective: To explore the cross talk between EpAT-derived adiponectin and myocardial redox state in the human heart. Methods and Results: EpAT and atrial myocardium were obtained from 306 patients undergoing coronary artery bypass grafting. Functional genetic polymorphisms that increase ADIPOQ expression (encoding adiponectin) led to reduced myocardial nicotinamide adenine dinucleotide phosphate oxidase-derived O-2(-), whereas circulating adiponectin and ADIPOQ expression in EpAT were associated with elevated myocardial O-2(-). In human atrial tissue, we demonstrated that adiponectin suppresses myocardial nicotinamide adenine dinucleotide phosphate oxidase activity, by preventing AMP kinase-mediated translocation of Rac1 and p47(phox) from the cytosol to the membranes. Induction of O-2(-) production in H9C2 cardiac myocytes led to the release of a transferable factor able to induce peroxisome proliferator-activated receptor-gamma-mediated upregulation of ADIPOQ expression in cocultured EpAT. Using a NOX2 transgenic mouse and a pig model of rapid atrial pacing, we found that oxidation products (such as 4-hydroxynonenal) released from the heart trigger peroxisome proliferator-activated receptor-gamma-mediated upregulation of ADIPOQ in EpAT. Conclusions: We demonstrate for the first time in humans that adiponectin directly decreases myocardial nicotinamide adenine dinucleotide phosphate oxidase activity via endocrine or paracrine effects. Adiponectin expression in EpAT is controlled by paracrine effects of oxidation products released from the heart. These effects constitute a novel defense mechanism of the heart against myocardial oxidative stress.

Published
2016

11. Mutual Regulation of Epicardial Adipose Tissue and Myocardial Redox State by PPAR-gamma/Adiponectin Signalling

Author

Antonopoulos, Alexios S. Margaritis, Marios Verheule, Sander and Recalde, Alice Sanna, Fabio Herdman, Laura Psarros, Costas and Nasrallah, Hussein Coutinho, Patricia Akoumianakis, Ioannis and Brewer, Alison C. Sayeed, Rana Krasopoulos, George and Petrou, Mario Tarun, Akansha Tousoulis, Dimitris Shah, Ajay M. Casadei, Barbara Channon, Keith M. Antoniades, Charalambos

Abstract

Rationale: Adiponectin has anti-inflammatory effects in experimental models, but its role in the regulation of myocardial redox state in humans is unknown. Although adiponectin is released from epicardial adipose tissue (EpAT), it is unclear whether it exerts any paracrine effects on the human myocardium. Objective: To explore the cross talk between EpAT-derived adiponectin and myocardial redox state in the human heart. Methods and Results: EpAT and atrial myocardium were obtained from 306 patients undergoing coronary artery bypass grafting. Functional genetic polymorphisms that increase ADIPOQ expression (encoding adiponectin) led to reduced myocardial nicotinamide adenine dinucleotide phosphate oxidase-derived O-2(-), whereas circulating adiponectin and ADIPOQ expression in EpAT were associated with elevated myocardial O-2(-). In human atrial tissue, we demonstrated that adiponectin suppresses myocardial nicotinamide adenine dinucleotide phosphate oxidase activity, by preventing AMP kinase-mediated translocation of Rac1 and p47(phox) from the cytosol to the membranes. Induction of O-2(-) production in H9C2 cardiac myocytes led to the release of a transferable factor able to induce peroxisome proliferator-activated receptor-gamma-mediated upregulation of ADIPOQ expression in cocultured EpAT. Using a NOX2 transgenic mouse and a pig model of rapid atrial pacing, we found that oxidation products (such as 4-hydroxynonenal) released from the heart trigger peroxisome proliferator-activated receptor-gamma-mediated upregulation of ADIPOQ in EpAT. Conclusions: We demonstrate for the first time in humans that adiponectin directly decreases myocardial nicotinamide adenine dinucleotide phosphate oxidase activity via endocrine or paracrine effects. Adiponectin expression in EpAT is controlled by paracrine effects of oxidation products released from the heart. These effects constitute a novel defense mechanism of the heart against myocardial oxidative stress.

Published
2016

13. Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase

Author

Reilly, Svetlana N., primary, Liu, Xing, additional, Carnicer, Ricardo, additional, Recalde, Alice, additional, Muszkiewicz, Anna, additional, Jayaram, Raja, additional, Carena, Maria Cristina, additional, Wijesurendra, Rohan, additional, Stefanini, Matilde, additional, Surdo, Nicoletta C., additional, Lomas, Oliver, additional, Ratnatunga, Chandana, additional, Sayeed, Rana, additional, Krasopoulos, George, additional, Rajakumar, Timothy, additional, Bueno-Orovio, Alfonso, additional, Verheule, Sander, additional, Fulga, Tudor A., additional, Rodriguez, Blanca, additional, Schotten, Ulrich, additional, and Casadei, Barbara, additional

Published
2016
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15. Mutual Regulation of Epicardial Adipose Tissue and Myocardial Redox State by PPAR-γ/Adiponectin Signalling

Author

Antonopoulos, Alexios S., primary, Margaritis, Marios, additional, Verheule, Sander, additional, Recalde, Alice, additional, Sanna, Fabio, additional, Herdman, Laura, additional, Psarros, Costas, additional, Nasrallah, Hussein, additional, Coutinho, Patricia, additional, Akoumianakis, Ioannis, additional, Brewer, Alison C., additional, Sayeed, Rana, additional, Krasopoulos, George, additional, Petrou, Mario, additional, Tarun, Akansha, additional, Tousoulis, Dimitris, additional, Shah, Ajay M., additional, Casadei, Barbara, additional, Channon, Keith M., additional, and Antoniades, Charalambos, additional

Published
2016
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16. Loss of Myocardial nNOS Mediated by Upregulation of miR-31 in Human Atria Contributes to Begetting of Atrial Fibrillation

Author

Liu, Xing, primary, Reilly, Svetlana, additional, Carnicer, Ricardo, additional, Recalde, Alice, additional, Muszkiewicz, Anna, additional, Jayaram, Raja, additional, Cristina Carena, Maria, additional, Stefanini, Matilde, additional, Wijesurendra, Rohan, additional, Lomas, Oliver, additional, Sayeed, Rana, additional, Krasopoulos, George, additional, Bueno-Orovio, Alfonso, additional, Rodriguez, Blanca, additional, and Casadei, Barbara, additional

Published
2016
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19. Abstract 5448: Regulatory T Cells Control Post-Ischemic Neovascularization

Author

Zouggari, Yasmine, primary, Ait-Oufella, Hafid, additional, Waeckel, Ludovic, additional, Vilar, José, additional, Loinard, Céline, additional, Cochain, Clément, additional, Recalde, Alice, additional, Duriez, Micheline, additional, Levy, Bernard, additional, Lutgens, Esther, additional, Mallat, Ziad, additional, and Silvestre, Jean-Sebastien, additional

Published
2008
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