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This research presents a study on the production of biojet fuel using crude palm kernel oil (CPKO) as a novel source. The aim of the research is to explore an efficient and high-throughput process for biojet production from CPKO. The experiment was conducted using a reactor packed with 5 wt% platinum on carbon (Pt/C). Several key operating variables, such as reaction temperature, hydrogen-to-nitrogen ratio, pressure, gas flow rate, and CPKO flow rate, were investigated to optimize the yield of liquid product and biojet fuel. The optimal conditions determined were a reaction temperature of 400 °C, pressure of 500 psi, CPKO flow rate of 0.02 mL/min, hydrogen-to-nitrogen ratio of 75:25, and gas flow rate of 25 mL/min. Under these conditions, the biojet fuel yield reached 59 %, with a productivity of 330.6 gproduct/gcat-h. The results demonstrated superior production performance compared to other existing processes in the field.

Currently, there is a lack of evidence for empiric use of antimicrobial agents in most patients with COVID-19 in outpatient and hospital settings as the overall proportion of secondary bacterial infections in COVID-19 is quite low. This literature review summarizes data on changes in antimicrobial resistance over the course of COVID-19 pandemic, especially in nosocomial ESKAPE pathogens. The other significant consequences of excessive and unnecessary administration of antibiotics to COVID-19 patients including risk of Clostridioides difficile infection and adverse effects of antimicrobial agents are also discussed.

Sylwia Lipko-Godlewska,1 Željana Bolanča,2,3 Lucie Kalinová,4 Irēna Kermen,5 Boris Onisak,6 Ildikó Papp,7 Margarita Rebrov,8 Greta Valančienė9 1Private Practice, Cracow, Poland; 2University Clinical Hospital Center “Sestre Milosrdnice”, Zagreb, Croatia; 3Private Clinic Milojević, Zagreb, Croatia; 4Nemocnice Bulovka, Praha, Czech Republic; 5Private Practice, Riga, Latvia; 6Nobilis, Maribor, Slovenia; 7Koruti Orvosesztetikai Centrum, Budapest, Hungary; 8East-Tallinn Central Hospital, Tallinn, Estonia; 9Private Practice, Kaunas, LithuaniaCorrespondence: Sylwia Lipko-GodlewskaPrivate Practice, 30th Kasztelanska St., No. 2, Cracow, 30-116, PolandTel +48 660 483 865Email sgodlewska@gmail.comAbstract: The use of hyaluronic acid fillers in aesthetic medicine has changed over the years and the procedure became one of the most common in the world. Understanding the ageing process of the face and the anatomical interrelationships in the face have dramatically influenced the use of the hyaluronic acid fillers and the assessment of the patient. It was supported by a new technology of products and by the delivery of tools (eg, blunt cannulas), face imaging, and innovative injection techniques. The whole-face approach challenges the practitioner to look at the face as a whole, and the patient to trust and rely on the treatment plan. Over the years, we have understood, that the most important outcome of aesthetic procedures is what does the whole face look like not static but in motion, and how do people read emotions from it. Nowadays, the result changes “the face information” and makes aesthetic procedures more satisfactory. In this manuscript, we reviewed essentials of the current treatment approach including patient’s consultations, product selection and injection techniques used in different parts of the face. One size fits none; thus, we provided a general overview of hyaluronic acid fillers used in different indications and presented several treatment approaches to each region of the face.Keywords: hyaluronic acid, whole-face approach, aesthetic medicine

The French thinker Louis Althusser is known primarily as a founder of Structural Marxism - a philosophical trend that originated in the 60s and 70s of the 20th century and based on the new interpretation of Marx's theory. This approach calls into question the lack of independent status of the political within the Marxist intellectual tradition, which was often expressed in the economic interpretation of any political process. In addition, Althusser was also the founder of his own scientific school, the influence of which was experienced by many key representatives of modern political philosophy. The purpose of this research is to characterize the evolution of the post-Althusserian political philosophy on the basis of comparing the ideas of some of its representatives with the source texts of Althusser. The author of the article, relying on the hermeneutical method of P. Riker, tries to build a general genealogy of various trends of post-Althusserianism, analyzing the works of such thinkers as E. Balibar, A. Negri, J. Ranciere, A. Badiou, E. Laclau, and Ch. Mouffe. The study reveals that the most significant differences between the approaches of these authors are in their original interpretations of policy and the political as fundamental concepts of political philosophy. Based on a comparative analysis, the author of the article identifies three key directions of modern post-Althusserianism and comes to the conclusion that their representatives rely on Althusser's works belonging to different periods of his oeuvre. Further divergence in interpretation of the Althusserian legacy occurred under the influence of other directions of socio-political philosophy, including Workerism (or Operaismo), theories of G. Deleuze, A. Gramsci, and C. Schmitt. Eventually, all this has led to the formation of various approaches to the definition of the political in the post-Althusserian paradigm.

The theoretical analysis of the maximum pressure on the soil of tractor tires with different methods of tractor ballasting is presented. The mathematical model of an empty and liquid ballasted agricultural tire is presented. Problem. As the standards of the running systems of mobile agricultural machinery on the soil limit the maximum pressure of wheeled trac-tors on the soil, there is a contradiction between high traction efficiency and harmful effects on the envi-ronment. The goal of the research is to perform a comparative analysis of the maximum tire pressure on the soil with two methods of increasing the trac-tor's weight: by installing cast iron ballast and filling the tires with ballast liquid. In solving the final goal, a methodology that provided the analytical methods for evaluating the effect of the tire filling with ballast fluid on its stiffness, load capacity and the area of contact area with the soil, is used. As a result it has been found that the tire stiffness increases by 3.5–5.5% when filled with 75% and practically does not change when filled with 40% by liquid ballasting. Cast iron ballasting is a versatile way to increase tractor weight, with maximum soil pressure 4.5–6.5% lower than tire liquid filling. Options for 75% and 40% liquid ballast for the use of water and calcium chloride solution as ballast liquid are considered. The originality of the work is to determine the maxi-mum pressure on the soil of the agricultural tire ballasted with liquid and to compare it with traditional cast iron ballasting by the level of maximum pressure on the topsoil. The practical value of the work is, at the stage of designing or upgrading the wheeled tractor, to provide recommendations on possible method of the tractor ballasting, taking into account the agro–environmental requirements for maximum soil pressure.

The paper reveals the influence exerted on the development of post vitro grape mother plants and various microzones found on the Ust-Donetsk sand massif. The differences in the microzones were in the fertility level and a number of soil properties. The considerable influence provided by the growing conditions not only on the development of plants but also on the survival rate and life expectancy of mother bushes observed during the use of mother plants for 17 years has been noted. To ensure effective land management, a detailed site study and, depending on the differences identified, the use of precision farming techniques is required before laying out the parent plants. The reason for this is that sandy soils, in general, have a high degree of heterogeneity due to physical and chemical characteristics such as flowability, susceptibility to wind transport, low organic substance content, and cation exchange capacity.

The article examines the current mechanism of state management of the regional agroindustrial complex, studies the business processes of entrepreneurship in the agro-industrial complex of Russia and suggests methods to increase their activity. A digital methodology for making and optimizing management decisions is proposed, based on a multi-criteria assessment of an operating enterprise, district, region as a system that allows optimizing their activities.

Averyan Vasylyev,1 Valentina Molostvova,2 Boris A Rebrov,3 Janina Makarova,4 Andrey Zaritskey,5 Vadim Ptushkin,6 Raigul Ramazanova,7 Yuriy Popovych,8 Orest Tsyapka,9 Evgeny Pashanov10 1CIS Medical, GlaxoSmithKline, Kiev, Ukraine; 2Regional Clinical Hospital No. 1, Khabarovsk, Russia; 3Lugansk Regional Clinical Hospital, Lugansk, Ukraine; 4Russia Medical Department, GlaxoSmithKline, Moscow, Russia; 5Oncohaematology Department, Almazov Federal Heart, Blood and Endocrinology Centre, Saint Petersburg, Russia; 6S.P. Botkin Hospital, Moscow, Russia; 7Kazakh Scientific Research Institute of Oncology and Radiology, Almaty, Kazakhstan; 8Zakarpatskaya Regional Clinical Hospital, Zakarpatskaya, Ukraine; 9Institute of Blood Pathology and Transfusion Medicine, Lviv, Ukraine; 10Novartis Pharma LLC, Moscow, Russia Purpose: The LEUKOSPECT study aimed to describe health service utilization and to estimate the direct medical costs (DMCs) of chronic lymphocytic leukemia (CLL) in 2013 in the adult population of three post-Soviet countries – Russia, Ukraine, and Kazakhstan. As oncologic medical care is provided by federal state-owned, specialized medical institutions, the cost estimation in this study primarily informs from a state budget perspective. Patients’ contributions to medical costs were not included in the cost evaluation.Patients and methods: This was a multinational, multicenter, retrospective study conducted in eight specialized centers (four in Russia, three in Ukraine, and one in Kazakhstan). The investigators captured data from the medical documents of all adult patients with an established CLL diagnosis before December 31, 2013, and who made at least one visit to their respective center between January 1 and December 31, 2013.Results: A total of 319 adult CLL patients were enrolled (124 in Kazakhstan, 106 in Russia, and 89 in Ukraine). In 2013, the DMCs of CLL management (without CLL therapy) were €215.40 in Kazakhstan, €1,342.20 in Russia, and €13,260.70 in Ukraine. Hospitalizations formed the largest proportion of total cost: 18.1%, 23.1%, and 40.4%, respectively. The mean cost of CLL medical treatment was €13,580.60 (Russia), €399.40 (Kazakhstan), and €7,453.00 (Ukraine).Conclusion: CLL treatment standards varied across the selected countries; higher usage of biologic therapy was noted in Russia. Future research is needed to assess DMCs which include CLL treatment, which is another essential factor contributing to CLL DMCs. Keywords: chronic lymphocytic leukemia, standard of care, direct medical cost, Russia, Ukraine, Kazakhstan

This work is devoted to the investigation of the possibility of the use of Ru-containing catalysts on the basis of polymeric matrix of hypercrosslinked polystyrene (HPS) in the hydrogenation of levulinic acid (LA) to gamma-valerolactone (GVL). HPS-based Ru-containing catalysts were synthesized at variation of HPS type (MN100 bearing amino groups or MN270 without functional groups) and metal content. Catalyst 5%-Ru/MN100 was shown to compete with commercial 5%-Ru/C and to allow carrying out the hydrogenation of LA in aqueous medium with high yields of GVL (more than 99%).

Measurement of the central aortic pressure and the augmentation may have additional benefits for characterizing the state of the cardiovascular system than the only stiffness of the vascular wall. The purpose of the study is to assess the changes of indicators of central aortic pressure and arterial stiffness in women of early postmenopausal period, against the background of the prolonged use of menopausal hormone therapy 1 mg E2 / 2mg DRSP. Material and Methods. The study included 162 women in early postmenopause. The subjects were divided into 2 groups: primary — 84 patients, which was appointed menopausal hormone therapy 1 mg E2 / 2mg of DRSP (drug "Angelique", Bayer), control group — 78 women who did not receive menopausal hormone therapy. The duration of observation is 5.2 years. ABPM was performed with the evaluation indicators of arterial stiffness (RWTT, Alx, ASI, AASI, (dP/dt) max.), central aortic pressure, aoPW. Results. Initial aoPW increase was detected in 15 (21.4%) women of the main group and in 19 (24.3%) control group patients (p=0,4). The women in both groups showed an increase to the end of the study aoPW more pronounced in women of control group. Increasing falls detected in 25 (29.7%) women of the main group and in 25 (32%) women of control group (p=0.84). It was noted that in women in both groups a significant decrease of central aortic pressure has been matched. In women of the main group to the end of the study there was a reduction in pulse pressure from 38,4±6,2 to 35,3±4,19mm Hg (p

The article represents the history of the Hospital Therapy Department at the Saratov State Medical University served as a basis for new departments' organization. The stages of its development are highlighted.

The article describes the perspective forms of the student scientific society sessions. Interdepartmental and inter-university conferences open new opportunities for a comprehensive interdisciplinary approach to a particular scientific problem, broadening the knowledge horizon and facilitating the acquisition of the students' discussion and speech experience. Intellectual game as one of the new active forms of the student scientific society sessions was developed at the Department of Hospital Therapy in order to increase the interest to the discipline "Internal Diseases" and involve new students in the scientific activity of the department.

The article represents the history of the first Department of Therapy at the University founded in September 1911 and describes the stages of its development.

The article discusses the effect of a cross-linked copolymer of potassium and ammonium salts of acrylic acid “Aquasin” on in vitro revitalized grape plants when adapting to non-sterile conditions and growing completion before planting in open ground. The research was carried out on the basis of VNIIViV named after Ya.I. Potapenko on the indigenous Don variety Krasnostop Zolotovsky and the indigenous Crimean variety Kandavasta. The aim of the study was to study the usage effectiveness of super absorbents (hydrogels) for the post vitro stage. As a result, the positive effect of adding the water-retaining agent Aquasin to the substrate on the growth and development of plants was noted. This was especially reflected in such indicators as ripening and the shoots’ diameter. In addition, the possibility of preliminary saturation of the super absorbent with immunostimulants or fertilizers is of interest.

The aim of the study was to evaluate the incidence of chronic kidney disease (CKD) in patients with chronic back pain and nonsteroidal anti-inflammatory drugs (NSAIDs) intake not less than a year, and to study the interrelation between CKD, peculiarities of pain and its treatment. Material and Methods. 91 patients with axial spondyloarthri-tis — ax-SpA(ankylosing spondylitis and non-radiographic ax-SpA) and 35 patients with degenerative diseases of the spine (DDS) with NSADs intake not less than 1 year were involved in the study. The control group included healthy volunteers who did not took NSAIDs during the last year (n=51). By age, gender, factors of cardiovascular risk, GFR in patients with ax-SpA, DDS and controls were comparable. The activity of pain was evaluated according to the accepted recommendations. The index of NSAID intake as calculated for the preceding year. Results. GFR in patients with ax-SpAwas 87,0 [77,25; 102,0] ml/min/1,73 m2, 11 (18%) patients showed a reduction in GFR of less than 60 ml/ min/1,73m2. In patients with DDS GFR was 87,5 [65,5; 97,0] ml/min / 1,73 m 2 (p=0,27), decreased GFR of less than 60 ml/min / 1,73 m2 was detected in 3 (15%) patients. The ratio of albumin / creatinine urine in patients with ax-SpA was 35,8 [25,46; 43,4] mg/g, in patients DDS —207,1 [91,66; 244,59] mg/g (p

The results of studies on the development of culture medium for initiation grape meristems into in vitro culture in order to increase their regenerative capacity during recovery from chronic diseases are presented. In the improved medium, in comparison with analogs, the total content of macro salts was reduced and their ratio was optimized, taking into account their consumption and the characteristics of their absorption from the nutrient solution by the grape plant. In the course of testing the new culture medium, its effectiveness has been established for grape varieties from various ecological and geographical groups. A higher and more stable percentage of survival and regeneration of extremely small meristems have been established against the background of various modifications of the recipe for the traditionally used culture medium of Murashige and Skoog.

An influence of different sucrose concentrations in the culture media on the photosynthetic parameters, photosynthetic apparatus related genes expression, oxidative processes and acclimation of grape plants cultured in vitro was examined in this article. An increase of the sucrose concentration in the culture media resulted in a reduced expression of several photosynthetic genes. The most effective functioning of the photosynthetic apparatus was discovered by a decreased amount of surcose in culture media. An increase of the sucrose concentration in the culture media disrupts pigments synthesis, particularly carotenoids, which can be a cause of the secondary oxidative stress formation and grape plants growth reduction during acclimation.

Results of researches on development of substrate for input of meristems of grapes are provided to the culture of in vitro for the purpose of increase in their regenerative ability at improvement from chronic diseases. In the advanced environment in comparison with analogs the general content of macrosalts was reduced and their ratio taking into account consumption and features of their absorption from nutrient solution is optimized by grape plant. During tests of new substrate its efficiency for grapes grades from various environmental-geographical groups was established. Higher and stable percent of survival and regeneration of extremely small meristems, against the background of various modifications of copy-book of traditionally applied substrate of Murasige and Skuga is established.

The scale-up of a radiofrequency (RF) heated micro trickle bed reactor for hydrogenation of 2-methyl-3-butyne-2-ol (MBY) over a Pd/TiO2 catalyst has been performed. The axial and radial temperature profiles were calculated using a 2D convection and conduction heat transfer model. The effect of the reactor length, tube diameter and number of parallel tubes on the temperature non-uniformity parameter has been studied. The axial scale-up was achieved by repeating a single periodic unit consisting of one heating and one catalytic zone along the reactor length. The catalyst loading can be increased by an order of magnitude following this approach. A radial temperature difference of 2 K was developed in a reactor with an inner diameter of 15 mm. The scale-up by numbering up allows the accommodation of seven parallel tubes inside a single RF coil. It creates a 7 K difference in the average temperature between the central and the outer tubes which results in a 5% difference in MBY conversion. An overall scale-up factor of near 700 is achieved which corresponds to a production rate of 0.5 kg of product/day.

The article is devoted to the technical analysis of building ceramics referring to the Saltovo-Mayatskaya archaeological culture. Several groups of building material were investigated. They were obtained in the course of archaeological excavations and collecting on the territory of the Semikarakor hill fort site, the Pravoberezhny Tsimlyansk hill fort site, and some other Khazar Khaganate monuments dated by 2nd half of the 8th – early 10th centuries, as well as on the territory of former Cossack settlements, where the bricks were used secondarily. The results of laboratory research and testing of various construction materials of the Saltovo period are represented in the article: burnt and adobe bricks, tiles, ceramides, etc. The qualitative indicators of these materials and their comparative evaluations are cited. The technological parameters and processes applied in the manufacture of building ceramics are reconstructed. The methods currently used to assess the quality and to control production processes of modern building ceramics, were applied to test the archaeological samples submitted. The different kind of raw materials and finished products resulting from their usage are characterized. An attempt was made to reproduce the process of building ceramics manufacture typical of the Khazar Khaganate period using experimental archeology methods. The experimental reconstruction of manufacturing and firing of the Semikarakor-Sarkel type bricks in the laboratory and field conditions is described.

The article discusses the succession of teaching of basic and clinical (therapeutic) disciplines in higher medical school: the urgency and necessity of interdisciplinary cooperation, its form, expected results, existing obstacles and ways to overcome them. The experience cathedral groups in the implementation of the process and prospects of further interdisciplinary cooperation in teaching basic science education and internal medicine.

Objective: to estimate the structure and frequency of detection of secondary diseases in patients with neurological manifestations of HIV infection. Materials and methods. The study involved 304 patients infected with HIV. Results. The defeat of the nervous system in HIV infection occur encephalopathy, cerebral vascular lesions, meningitis, subacute encephalitis, secondary CNS lesions. The number of CD4-lymphocytes in HIV-infected patients with neurological disorders was significantly lower. Most of them have comorbid diseases. The most commonly diagnosed hepatitis С and B, herpes, cytomegalovirus infection, chlamydia, Candida, toxoplasmosis and tuberculosis, mixed infection. Hepatitis В and С and herpes are the most widely represented in patients with HIV-induced encephalopathy and cerebrovascular form of HIV. The presence of cytomegalovirus infection is correlated with the development of subacute encephalitis. Conclusion. Manifestations of nervous system pathology in HIV polymorphic and correlated with the presence of secondary comorbid pathology. Such conditions are due to underlying disease immunological parameters.

The article describes the experience of the organization of Olympiad in Internal medicine at the medical university for senior students and clinical residents. The paper presents the possibility of Olympiad in Internal medicine at the medical university is a modern educational technology that increases interest to the disciplines and motivation to professional development and formation of professional competencies. Such type of Olympiad helps future therapeutics to improve in their specialty and to form a personal reserve for the future work in the medical and research team, promotes continuity between students and postgraduate trainers in higher professional medical education.

Introduction. Patients with rheumatoid arthritis (RA) suffer from psychosocial maladaptation due to pain syndrome, limitation of activity with loss of ability to work and social connections. The presence of anxiety-depressive disorders (ADD) increases the incapacity of patients with RA in the first five years of illness from 25.0 to 50.0% Aim. Optimize RA treatment at an early stage (eRA) in combination with ADD, using a ramipril inhibitor of the angiotensin converting enzyme (ACE) in the treatment complex. Materials and methods. The examination of 179 patients with undifferentiated arthritis that was treated at the rheumatologic department of the Luhansk Regional Clinical Hospital revealed 95 people with eRA. The age of patients ranged from 22 to 59 years (on average, 41.27 ± 10.41 years), among them 16.8% of men and 83.2% of women aged 40.3 ± 9.22 years and 41.2 ± 10, 27 years old respectively. The duration of the disease – 1-28 months. RA diagnosis was verified according to the criteria of ASR/EULAR, 2010. The psychological status of all the patients was assessed using questionnaires of proven validity: the scale of hospital anxiety and depression (Hospital Anxiety and Depression Scale, HADS); the presence and severity of depression were assessed on Beck’s scale. Results. It has been established that patients with eRA with ADD due to complex treatment using ramipril are likely to decrease the morning stiffness, the number of painful and edematous joints, the health status according to VAS and HAQ (p

The aim of the study was to determine correlation between arterial blood pressure daily rhythm and daily profile of arterial stiffness in male patients with chronic obstructive pulmonary disease (COPD) and arterial hypertension. Materials et methods: Prospective investigation comprised 45 male patients with COPD and arterial hypertension. Individuals of 40 years younger and 80 years elder, patients with diabetes, stroke, angina pectoris, or heart infarction, vascular diseases, and exacerbation of chronic disease, bronchial and pulmonary diseases of other etiology were excluded from the analyses. Comparison group included 47 patients with essential arterial hypertension and without chronic respiratory diseases closely similar on general parameters with patients from main clinical series. Twenty-four-hour arterial blood pressure monitoring (ABPM) and daily arterial stiffness monitoring were performed using BPLab® MnSDP-2 apparatus (Petr Telegin, Russian Federation). Results: Patients with COPD combined with arterial hypertension with raised arterial stiffness measures prevail over individuals in essential hypertension group. There is pathological alteration of the ABPM circadian rhythm and raised «Pressure load» values in raised arterial stiffness group. Conclusion: We found ABPM raised parameters in patients with COPD and arterial hypertension. It confirms necessity of ABPM in daily arterial stiffness assessment in patients with COPD.

The research goal is to determine low-frequency AMF effect on dissolution of urinary stone material in vitro in water with human urinary stones (oxalate type). Materials and Methods. The structural changes in aqueous solutions may occur when exposed to low-frequency alternating magnetic fields (AMF). It depends on chemical composition of the solutions under the study. Results. Organic components (63.1 %), leading to the density decrease of the solution, urea (18.8%), leading to its increase, and oxalic acid (19.7%) have been determined in stone composition. The decrease of transmittance T (%) by the time of oxalate dissolution has indicated increase in concentration of dissolved sample. The sample has been exposed to AMF of 2-9 Hz on the background of the control sample. The growth of this dependence with AMF increasing of 11-22 Hz has established less concentration of dissolved sample in the test solution than in the control one. Conclusion. The main task has been to determine the influence of AMF of 2-22 Hz on solubility of urinary stones placed in water for an hour. The article is to conclude that maximal solubility of oxalate mineral sample by AMF of 2-22 Hz has been reached. It is 14% more than in the control solution. The effectiveness of AMF influence on solubility of organomineral decreases with frequency increasing. It has been confirmed by photometric and areometric measurements.

We have presented the review of literature devoted to the problem of pancreatogenic diabetes mellitus. We have found up that prevalence of pancreatogenic diabetes mellitus needs to be adjusted. In analyzed literature the influence of localization of structural changes of pancreatic tissue on risk of diabetes mellitus development is studied insufficiently. In the result of our literature analysis we have detected that treatment of pancreatogenic diabetes mellitus up to date is not unified and is mostly descriptive, what indicates on necessity of further investigations in order to optimize and increase the efficacy of its treatment.

Aim: to evaluate arterial wall rigidity, clinical condition and prognosis in active and standard therapy of patients with chronic heart failure (CHF). Materials and methods. A total of 211 patients with CHF experienced Q-wave myocardial infarction was enrolled in the study. At admission to the hospital all patients were randomized into two groups. Patients of the first group (n=106) were managed actively after discharge from the hospital, patients of the second group (n=105) were managed conventionally after discharge from the hospital. Patients were observed for three years. Re-sults. Over three year-investigation actively managed patients demonstrated significant (p

This review provides a general overview of recent applications of magnetic nanoparticles for controlled radiofrequency (RF) heating in catalytic synthesis, mass transfer enhancement in laminar flow and magnetic separation. By directly delivering RF energy to magnetic materials, issues such as long heating periods and energy losses can be minimized. The main mechanisms of RF heating are briefly reviewed. The effect of nanoparticles size, shape and composition on the efficiency of RF heating is discussed. RF energy has been shown to be effective in many applications, however, it is still not used in chemicals due to high equipment costs.

Aim. To investigated endothelial dysfunction in patients with systemic lupus erythematosus (SLE), depending on different activity, duration of disease and different type of therapy. Methods. We examined 77 patients with SLE during 1 year. We administered puls therapy with high dose glucocorticoids and cyclophosphamide in the 33 patients. 44 patients were given low dose steroids orally or hydroxychloroquine. We investigated the number of circulating endothelial cells in peripheral blood. Vasoactive function was assessed in reactive hyperemia test, antitrombogenic function with short-lived ischemia was examined. Results. Patients with SLE demonstrated endothelial damage, its antitrombogenic and vasodilatation function was reduced especially in high activity of disease. Pulse therapy improved endothelial function after 12-month treatment periods. The activity of the SLE decreased what was associated with reduced endothelial damage. Also vasodilatation function improved, but anticoagulant activity was without changes. Conclusion. It is necessary to administer pulse therapy according to the right indication despite potential danger of steroids and cyclophosphamide on endothelial function. Probably pulse therapy should be used with vasoprotective drugs in order to improve anticoagulant function

The article presents the research results on the role of leading clinical predictors in follow-up prognosis for patients with ischemic heart disease. The inefficiency of socialization in a non-terminal condition is formed by means of insufficiency of somatic, psychological and social resources in patients. Thus clinical predictors have no significant value

The research goal is to present the clinical observation that shows possibility of combination of low clinical and laboratory activity of psoriatic arthritis with 1) a large amount of exrtaarticular manifestations; 2) severe lesion of internal organs; 3) development of nephritis and hepatitis; 4) cardiovascular system pathology. The possibilities of different diagnostic and therapeutic methods have been considered in the article

Objective: to found the dyslipidemia in patients with psoriatic arthritis and to study the connection between dyslipidemia and cardiovascular risk factors, atherosclerosis and inflammation activity. 40 persons with PsA without cardiovascular diseases were involved in the study, 25 healthy people were examined like controls. Activity of PsA was learned by DAS, Likert index, Ritchie Arthicular Index, Number of swelling joints (NSJ), ESR, C-reactive protein (CRP) and fibrinogen. Total cholesterol, triglycerides, low and high density lipoprotein cholesterol, hypertension, body mass index, individual cardiac history were performed like cardiovascular risk markers. The ultrasound measuring the thickness of intima-media layer (IML) in carotid arteries was performed to subclinical atherosclerosis study. Increase of total cholesterol, triglycerides and low density lipoprotein cholesterol level was found in patients with PsA comparative with controls. There was prevalence of high and moderate increase of total cholesterol in patients with PsA, and in controls only low increase was measured. Correlation between total cholesterol and NSJ, fibrinogen, hypertension and IML was found. Low density lipoproteins were tingly interrelated with ESR, hypertension and IML. Very low density lipoproteins were connected with age of disease beginning, hypertension and IML, and triglycerides-with hypertension, enthesitis and dactilitis. Dyslipidemia in patients with PsA characterizes by total cholesterol, triglycerides, low density lipoprotein cholesterol increase, but not high density lipoprotein decrease. There is the connection between dyslipidemia in PsA and inflammation activity, arterial hypertension and IML

The paper shows the topicality of the transition from the metering system for oil products at fuel depots and gas stations, organized with the help of automated measuring instruments, to the use of automated information and measurement systems for oil products metering (IMS OP) of a new generation. The structure diagram of the IMS OP is presented, the implementation of which allows solving the problem of formation of the normalized value of the unbalance between the actual results of measuring the mass of OP in the technological chain “Supplier - Distribution system – Consumer” and the current document flow. The basic algorithm of IMS OP operation is presented, as well as the results of its approbation as a part of IMS OP at the fuel depot of the Dno station of the October Railway.

The article describes core criteria, which define efficient application of energy accumulators in railway traction power supply system. Installation points for energy accumulators in electric power system of train electric drivers, where application is most effective, are identified. These points are railway sub-stations, electric traction network and traction power system. The main types of energy accumulators, which essentially can be used on railway transport in traction power system – traction sub-stations and traction network, electric motive power, are examined. They can be used on railway transport and. The quality factors of work for traction energy power and electric motive power are presented, improvement of which can be performed using energy accumulators. International experience of energy accumulators application for railway transport is presented. Russian developments and implementation of energy accumulators from domestic manufacturers are examined, both in the traction power system and in the electric rolling stock. The polygons for the most efficient use of energy storage in the traction power supplying system are identified.

The work presents the results of experiments on the diamond gas-jet synthesis from methane and hydrogen mixture, flowing from coaxial channels under the following conditions: temperature of the hydrogen activating surface of 2400 K, pressure in the deposition chamber of 20 Torr, different gas fluxes, and different CH4 concentrations. The Direct Simulation Monte Carlo method for numerical analysis of experiments was applied.

Algorithm of the direct simulation Monte Carlo method for the flow of hydrogen and methane mixture in a cylindrical channel is developed. Heterogeneous reactions on tungsten channel surfaces are included into the model. Their effects on flows are analyzed. A one-dimensional approach based on the solution of equilibrium chemical kinetics equations is used to analyze gas-phase methane decomposition. The obtained results may be useful for optimization of gas-dynamic sources of activated gas diamond synthesis.