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5. Contributors

Author

Aguiar, Barroso, primary, Bjelić, Ljiljana Stojanović, additional, Chlebicki, Andrzej, additional, de Carvalho, H. Paiva, additional, Dias, Marta, additional, Falkinham, Joseph O., additional, Farooqi, Zia Ur Rahman, additional, Gomes, Bianca, additional, Gomes, Inês B., additional, Ilić, Predrag, additional, Isola, Daniela, additional, Ivanov, Volodymyr, additional, Jerónimo, Alexandre, additional, Kocić, Đorđe, additional, Lima, Nelson, additional, Markić, Dragana Nešković, additional, Medina-Armijo, Cristy, additional, Menteşe, Sibel, additional, Mesquita, N., additional, Mira, Ana Rita, additional, Oliveira, Ketlyn, additional, Pacheco-Torgal, Fernando, additional, Pereira, Maria A., additional, Petrović, Nenad, additional, Pimenta, Raquel, additional, Pinheiro, A.C., additional, Ponte, Tomás, additional, Portugal, A., additional, Prenafeta-Boldú, Francesc X., additional, Reboux, Gabriel, additional, Ribeiro, Edna, additional, Rocchi, Steffi, additional, Simões, Lúcia C., additional, Simões, Manuel, additional, Soares, Célia, additional, Soares, F., additional, Spisak, Wojciech, additional, Stabnikov, Viktor, additional, Tiago, I., additional, Trovão, J., additional, and Viegas, Carla, additional

Published
2022
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13. Immunological Methods

Author

Reboux, Gabriel, Magy, Nadine, Dalphin, Jean-Charles, Baert, A. L., editor, Sartor, K., editor, De Vuyst, Paul, editor, and Gevenois, Pierre Alain, editor

Published
2006
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20. Factors associated with Pneumocystis colonization and circulating genotypes in chronic obstructive pulmonary disease patients with acute exacerbation or at stable state and their homes

Author

Gantois, Nausicaa, primary, Lesaffre, Aymerick, additional, Durand-Joly, Isabelle, additional, Bautin, Nathalie, additional, Le Rouzic, Olivier, additional, Nseir, Saad, additional, Reboux, Gabriel, additional, Scherer, Emeline, additional, Aliouat, El Moukhtar, additional, Fry, Stéphanie, additional, Gosset, Philippe, additional, and Fréalle, Emilie, additional

Published
2021
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21. Indoor microbial environment and asthma outcomes in childhood

Author

Bédard, Annabelle, primary, Rocchi, Steffi, additional, Khan, Sadia, additional, Dufourg, Marie-Noelle, additional, Delmas, Marie-Christine, additional, Charles, Marie-Aline, additional, Scherer, Emeline, additional, Reboux, Gabriel, additional, Raherison-Semjen, Chantal, additional, Millon, Laurence, additional, and Leynaert, Bénédicte, additional

Published
2021
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22. Whispers of change in childhood asthma: findings in the French ELFE cohort

Author

Khan, Sadia, primary, Ouaalaya, El Hassane, additional, Leynaert, Bénédicte, additional, De Blic, Jacques, additional, Marguet, Christophe, additional, Deschildre, Antoine, additional, Dufourg, Marie-Noëlle, additional, Bois, Corinne, additional, Charles, Marie-Aline, additional, Delmas, Marie Christine, additional, Divaret Chauveau, Amandine, additional, Scherer, Emeline, additional, Rocchi, Steffi, additional, Reboux, Gabriel, additional, Millon, Laurence, additional, and Raherison Semjen, Chantal, additional

Published
2021
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26. Home environment exposure assessment in hypersensitivity pneumonitis

Author

Rooijackers, Jos M., Zaat, Vanessa, Veltkamp, Marcel, Meijer, Martin, Houbraken, Jos, Scherer, Emeline, Reboux, Gabriel, Grutters, Jan, Rooijackers, Jos M., Zaat, Vanessa, Veltkamp, Marcel, Meijer, Martin, Houbraken, Jos, Scherer, Emeline, Reboux, Gabriel, and Grutters, Jan

Published
2020

28. Longitudinal study of anti-Candida albicans mucosal immunity against aspartic proteinases in HIV-infected patients

Author

Millon, Laurence, Drobacheff, Christine, Piarroux, Renaud, Monod, Michel, Reboux, Gabriel, Laurent, Rene, and Meillet, Dominique

Subjects
Oral mucosa -- Physiological aspects, Thrush (Mouth disease) -- Research, HIV infection -- Complications, Candida albicans -- Physiological aspects, Health
Abstract

Many HIV patients produce antibodies in their saliva against enzymes produced by Candida albicans. Unfortunately, the antibodies are not completely effective in preventing Candida infection of the oral mucosa, a condition commonly known as thrush.

Published
2001

31. External validation of Asthma prediction tool in the French ELFE cohort

Author

Khan, Sadia, primary, Leynaert, Bénédicte, additional, Rocchi, Steffi, additional, Deblic, Jacques, additional, Marguet, Christophe, additional, Deschildre, Antoine, additional, Scherer, Emeline, additional, Reboux, Gabriel, additional, Delmas, Marie Christine, additional, Dufourg, Marie-Noëlle, additional, Bois, Corinne, additional, Charles, Marie-Aline, additional, Divaret-Chauveau, Amandine, additional, Millon, Laurence, additional, and Raherison, Chantal, additional

Published
2020
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36. Indoor Microbiome: Quantification of Exposure and Association with Geographical Location, Meteorological Factors, and Land Use in France

Author

Rocchi, Steffi, primary, Reboux, Gabriel, additional, Scherer, Emeline, additional, Laboissière, Audrey, additional, Zaros, Cécile, additional, Rouzet, Adeline, additional, Valot, Benoit, additional, Khan, Sadia, additional, Dufourg, Marie-Noëlle, additional, Leynaert, Bénédicte, additional, Raherison, Chantal, additional, and Millon, Laurence, additional

Published
2020
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40. Factors associated with Pneumocystis colonization and circulating genotypes in chronic obstructive pulmonary disease patients with acute exacerbation or at stable state and their homes.

Author

Gantois, Nausicaa, Lesaffre, Aymerick, Durand-Joly, Isabelle, Bautin, Nathalie, Rouzic, Olivier Le, Nseir, Saad, Reboux, Gabriel, Scherer, Emeline, Aliouat, El Moukhtar, Fry, Stéphanie, Gosset, Philippe, and Fréalle, Emilie

Abstract

Pneumocystis jirovecii colonization is frequent during chronic obstructive pulmonary disease (COPD) and patients constitute potential contributors to its interhuman circulation. However, the existence of an environmental reservoir cannot be excluded. We assessed the prevalence and factors associated with Pneumocystis colonization during COPD, and studied circulation between patients and their domestic environment. Pneumocystis molecular detection and mtLSU genotyping were performed in oro-pharyngeal washes (OPW) sampled in 58 patients with COPD acute exacerbation, and in indoor dust, sampled in patients' homes using electrostatic dust collectors (EDCs). Lung and systemic inflammation was assessed. Pneumocystis carriage was evaluated in 28 patients after 18 months at stable state. Pneumocystis was detected in 11/58 OPWs during exacerbation (19.0%). Colonized patients presented a significantly lower body mass index, and higher serum IL-17 and CD62P. One patient presented positive detection of typable isolates in both OPW and EDC, with both isolates harboring mtLSU genotype 3. Pneumocystis genotype 1 was further detected in EDCs from three non-colonized patients and one colonized patient with non-typable isolate. Genotypes 1 and 2 were predominant in clinical isolates (both 42%), with genotype 3 representing 16% of isolates. Pneumocystis was detected in 3/28 patients at stable state (10.7%). These data suggest that Pneumocystis colonization could be facilitated by a lower BMI and be related to acute alteration of lung function during COPD exacerbation. It also suggests Th17 pathway and platelet activation could be involved in the anti- Pneumocystis response during colonization. Last, Pneumocystis detection in EDCs supports its potential persistence in indoor dust. Lay Summary Chronic obstructive pulmonary disease patients tend to be more frequently colonized by Pneumocystis during exacerbation (19.0%) than at stable state (10.7%). Factors associated with colonization include lower BMI, higher IL-17, and CD62P. Pneumocystis detection in patients' dwellings suggests potential persistence in indoor dust. [ABSTRACT FROM AUTHOR]

Published
2022
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44. Mould exposure in indoor environments: The French ANSES recommendations to reinforce measures for preventing mould growth and the impact on human health

Author

Keirsbulck, Marion, Aschan-Leygonie, Christina, Bayeux, Thomas, Bex, Valerie, Boulanger, Gabrielle, Bretagne, Stéphane, Caillaud, D., Colleville, A-C., Fourneau, C., Frealle, Emilie, Ginestet, Stéphane, Lecoq, Laetitia, Leynaert, B., Nadif, Rachel, F., Oswald, Reboux, Gabriel, Roussel, S., Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Environnement, Ville, Société (EVS), École normale supérieure de Lyon (ENS de Lyon)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Lumière - Lyon 2 (UL2)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-École Nationale des Travaux Publics de l'État (ENTPE)-École nationale supérieure d'architecture de Lyon (ENSAL)-Centre National de la Recherche Scientifique (CNRS), Service de parasitologie [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Laboratoire Matériaux et Durabilité des constructions (LMDC), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Physiopathologie et Epidemiologie de l'Insuffisance Respiratoire, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Environnement Ville Société (EVS), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-École nationale supérieure d'architecture de Lyon (ENSAL)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École Nationale des Travaux Publics de l'État (ENTPE)-Université Jean Monnet [Saint-Étienne] (UJM)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université Lumière - Lyon 2 (UL2)-École normale supérieure - Lyon (ENS Lyon), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Body, Salima, Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-École nationale supérieure d'architecture de Lyon (ENSAL)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), École normale supérieure - Lyon (ENS Lyon)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet [Saint-Étienne] (UJM)-École Nationale des Travaux Publics de l'État (ENTPE)-École nationale supérieure d'architecture de Lyon (ENSAL)-Centre National de la Recherche Scientifique (CNRS), Institut National des Sciences Appliquées (INSA)-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées (INSA)-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées

Subjects
[SHS] Humanities and Social Sciences, ComputingMilieux_MISCELLANEOUS, [SHS]Humanities and Social Sciences
Abstract

International audience

Published
2018

45. Wheezing phenotypes and risk factors in early life: The ELFE cohort

Author

Hallit , Souheil, Leynaert , Bénédicte, Delmas , Marie Christine, Rocchi , Steffi, De Blic , Jacques, Marguet , Christophe, Scherer , Émeline, Dufourg , Marie Noelle, Bois , Corinne, Reboux , Gabriel, Millon , Laurence, Charles , Marie Aline, Raherison , Chantal, Fehrenbach , Heinz, Bordeaux population health ( BPH ), Université de Bordeaux ( UB ) -Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Physiopathologie et Epidemiologie de l'Insuffisance Respiratoire, Université Paris Diderot - Paris 7 ( UPD7 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Santé publique France [Saint-Maurice] ( SPF ), Agence Nationale de la Santé Publique [Saint-Maurice] ( ANSP ), Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ) -Centre National de la Recherche Scientifique ( CNRS ), Service de parasitologie et mycologie [CHU de Besançon], Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ), CHU Necker - Enfants Malades [AP-HP], Service de pédiatrie médicale et médecine de l'adolescent [Rouen], CHU Rouen-Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Normandie Université ( NU ), INSERM-INED U822, Institut National de la Santé et de la Recherche Médicale, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Santé publique France [Saint-Maurice] (SPF), Agence Nationale de la Santé Publique [Saint-Maurice] (ANSP), Laboratoire Chrono-environnement - CNRS - UFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie et Epidémiologie des Maladies Respiratoires (PHERE (UMR_S_1152 / U1152)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Université Paris Diderot - Paris 7 - UFR Sciences du Vivant (UPD7 UFR Sciences du Vivant), Université Paris Diderot - Paris 7 (UPD7), Santé publique France - French National Public Health Agency [Saint-Maurice, France], Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Service de pédiatrie néonatale et réanimation - neuropédiatrie [CHU Rouen], Normandie Université (NU)-Normandie Université (NU)-Hôpital Charles Nicolle [Rouen]-Université de Rouen Normandie (UNIROUEN), Etude longitudinale française depuis l'enfance (UMS : Ined-Inserm-EFS) (ELFE), Institut national d'études démographiques (INED)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de parasitologie et mycologie [CHRU de Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Laboratoire Chrono-environnement (UMR 6249) (LCE), Hôpital Charles Nicolle [Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, and Admin, Oskar

Subjects
Male, Pulmonology, Physiology, Maternal Health, Eczema, lcsh:Medicine, Pathology and Laboratory Medicine, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Cohort Studies, Families, Pregnancy, Risk Factors, Surveys and Questionnaires, Allergies, Medicine and Health Sciences, Coughing, Longitudinal Studies, lcsh:Science, Children, Rhinitis, Allergic Diseases, Smoking, Obstetrics and Gynecology, Phenotype, Research Design, Maternal Exposure, Female, France, Algorithms, Research Article, Allergic Rhinitis, Immunology, Bronchi, Dermatology, Research and Analysis Methods, [ SDV.EE.SANT ] Life Sciences [q-bio]/Ecology, environment/Health, Signs and Symptoms, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, Diagnostic Medicine, Hypersensitivity, Humans, Secretion, Respiratory Sounds, Family Health, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, Siblings, lcsh:R, Biology and Life Sciences, Infant, Correction, Rhinology, Respiration Disorders, Asthma, Otorhinolaryngology, Cough, Age Groups, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, People and Places, Nasal Diseases, Women's Health, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Population Groupings, Clinical Immunology, lcsh:Q, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Clinical Medicine, Physiological Processes
Abstract

International audience; Objective: Different phenotypes of wheezing have been described to date but not in early life. We aim to describe wheezing phenotypes between the ages of two months and one year, and assess risk factors associated with these wheezing phenotypes in a large birth cohort.Methods: We studied 18,041 infants from the ELFE (French Longitudinal Study of Children) birth cohort. Parents reported wheezing and respiratory symptoms at two and 12 months, and answered a complete questionnaire (exposure during pregnancy, parental allergy).Results: Children with no symptoms (controls) accounted for 77.2%, 2.1% had had wheezing at two months but no wheezing at one year (intermittent), 2.4% had persistent wheezing, while 18.3% had incident wheezing at one year. Comparing persistent wheezing to controls showed that having one sibling (ORa = 2.19) or 2 siblings (ORa = 2.23) compared to none, nocturnal cough (OR = 5.2), respiratory distress (OR = 4.1) and excess bronchial secretions (OR = 3.47) at two months, reflux in the child at 2 months (OR = 1.55), maternal history of asthma (OR = 1.46) and maternal smoking during pregnancy (OR = 1.57) were significantly associated with persistent wheezing. These same factors, along with cutaneous rash in the child at 2 months (OR = 1.13) and paternal history of asthma (OR = 1.32) were significantly associated with increased odds of incident wheezing. Having one sibling (ORa = 1.9) compared to none, nocturnal cough at 2 months (OR = 1.76) and excess bronchial secretions at 2 months (OR = 1.65) were significantly associated with persistent compared to intermittent wheezing.Conclusion: Respiratory symptoms (cough, respiratory distress, and excessive bronchial secretion) were significantly associated with a high risk of persistent wheezing at one year. Smoking exposure during pregnancy was also a risk factor for persistent and incident wheezing

Published
2018

47. Effects of smoking and asthma in pregnant women

Author

Khan, Sadia, primary, Deschildre, Antoine, additional, De Blic, Jacques, additional, Marguet, Christophe, additional, Scherer, Emeline, additional, Reboux, Gabriel, additional, Delmas, Marie-Christine, additional, Leynaert, Benedicte, additional, Rocchi, Steffi, additional, Millon, Laurence, additional, Dufourg, Marie-Noelle, additional, Bois, Corinne, additional, Charles, Marie-Aline, additional, and Raherison, Chantal, additional

Published
2019
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50. Emergence of Aspergillus fumigatus azole resistance in azole-naïve patients with chronic obstructive pulmonary disease and their homes.

Author

Dauchy, C, Bautin, N, Nseir, S, Reboux, Gabriel, Wintjens, René, Le Rouzic, O, Sendid, B, Viscogliosi, Eric, Le Pape, P, Arendrup, Maiken Cavling Avling M.C., Gosset, Philippe, Fry, S, Fréalle, E, Dauchy, C, Bautin, N, Nseir, S, Reboux, Gabriel, Wintjens, René, Le Rouzic, O, Sendid, B, Viscogliosi, Eric, Le Pape, P, Arendrup, Maiken Cavling Avling M.C., Gosset, Philippe, Fry, S, and Fréalle, E

Abstract

Azole-resistant Aspergillus fumigatus (ARAF) has been reported in patients with chronic obstructive pulmonary disease (COPD) but has not been specifically assessed so far. Here, we evaluated ARAF prevalence in azole-naïve COPD patients and their homes, and assessed whether CYP51A mutations were similar in clinical and environmental reservoirs. Sixty respiratory samples from 41 COPD patients with acute exacerbation and environmental samples from 36 of these patient's homes were prospectively collected. A. fumigatus was detected in respiratory samples from 11 of 41 patients (27%) and in 15 of 36 domiciles (42%). Cyp51A sequencing and selection on itraconazole medium of clinical (n = 68) and environmental (n = 48) isolates yielded ARAF detection in 1 of 11 A. fumigatus colonized patients with COPD (9%) and 2 of 15 A. fumigatus-positive patient's homes (13%). The clinical isolate had no CYP51A mutation. Two environmental isolates from two patients harbored TR34/L98H mutation, and one had an H285Y mutation. Coexistence of different cyp51A genotypes and/or azole resistance profiles was detected in 3 of 8 respiratory and 2 of 10 environmental samples with more than one isolate, confirming the need for a systematic screening of all clinically relevant isolates. The high prevalence of ARAF in patients with COPD and their homes supports the need for further studies to assess the prevalence of azole resistance in patients with Aspergillus diseases in Northern France., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2018

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