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Introduction Post-transplant lymphoproliferative disorders (PTLDs) comprise a heterogeneous group of Epstein-Barr virus (EBV)-positive or negative lymphoid or plasmacytic lesions in solid organ or hematopoietic stem cell (HSC) transplant recipients. Although PTLDs in adults have been extensively studied, the clinicopathologic features of monomorphic B-cell PTLD in children, particularly EBV-negative forms, are still poorly understood. Methods We retrospectively reviewed all our pediatric cases of monomorphic B-cell PTLDs diagnosed in the past 10 years. Clinical data were reviewed. Pathologic data including histologic types and EBV status were analyzed. Additional immunohistochemical stains, FISH studies, and TP53 gene mutational status were performed. Results 4 of 18 cases were EBV-negative. All 4 EBV-negative cases were strikingly confined to the gastrointestinal (GI) tract or abdominal lymph nodes, while tumors in EBV-positive cases were found at various anatomic sites; 2 of 4 EBV-negative cases carried mutations in TP53 gene. Our cohort also included 2 rare types of PTLD, one plasmablastic lymphoma and one high-grade B-cell lymphoma, not otherwise specified (HGBL, NOS). Conclusion We report that monomorphic B-cell PTLDs in children have distinctive clinical and pathological features. More studies are needed to clarify whether and how much these pediatric PTLDs differ from their adult counterparts.

Background Huntington’s disease (HD) is a genetically inherited, autosomal dominant neurodegenerative disease which results in movement disorder, neuropsychiatric symptoms and cognitive deficits. While the clinical effects of HD have been independently implicated in forensic risk, there are few studies exploring the issue of forensic risk in HD. Aims To compare forensic risk factors in two HD patient groups (in-patients and out-patients). Methods Data was collected through a retrospective review of case notes for two subject groups, hospital in-patients at an HD specialist ward (n = 18) and out-patients living in the community (n = 10). Information was gathered regarding forensic history and incidents of physical aggression along with demographic details including legal status, gender and age. Fisher’s exact tests and regression analyses assessed relationships between the prevalence of forensic history and physical aggression with gender and patient status i.e. in-patient or out-patient. Results Fisher’s exact tests demonstrated that gender and patient status were independent of both forensic history and physical aggression. Kendall’s tau-b tests further supported these findings with no significant correlations found, with the exception of forensic history and patient status (inpatient vs. outpatient) which demonstrated a weak to moderate correlation (0.304, p Conclusion The current study provides preliminary evidence to suggest that there is no correlation between HD and an increased forensic risk within the HD population. However, it was more likely that the hospital in-patients had a forensic history.