Search

Your search keyword '"Rebecca Moos"' showing total 4 results
Start Over Author "Rebecca Moos"
4 results on '"Rebecca Moos"'

1. Human-Biomonitoring derived exposure and Daily Intakes of Bisphenol A and their associations with neurodevelopmental outcomes among children of the Polish Mother and Child Cohort Study

Author

Mercè Garí, Rebecca Moos, Daniel Bury, Monika Kasper-Sonnenberg, Agnieszka Jankowska, Aleksandra Andysz, Wojciech Hanke, Dennis Nowak, Stephan Bose-O’Reilly, Holger M. Koch, and Kinga Polanska

Subjects
Birth cohort, Bisphenol A, Children, Daily Intake, Neurodevelopment, Poland, Industrial medicine. Industrial hygiene, RC963-969, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Bisphenol A (BPA) is an industrial chemical mostly used in the manufacture of plastics, resins and thermal paper. Several studies have reported adverse health effects with BPA exposures, namely metabolic disorders and altered neurodevelopment in children, among others. The aim of this study was to explore BPA exposure, its socio-demographic and life-style related determinants, and its association with neurodevelopmental outcomes in early school age children from Poland. Methods A total of 250 urine samples of 7 year-old children from the Polish Mother and Child Cohort Study (REPRO_PL) were analyzed for BPA concentrations using high performance liquid chromatography with online sample clean-up coupled to tandem mass spectrometry (online-SPE-LC-MS/MS). Socio-demographic and lifestyle-related data was collected by questionnaires or additional biomarker measurements. Emotional and behavioral symptoms in children were assessed using mother-reported Strengths and Difficulties Questionnaire (SDQ). Cognitive and psychomotor development was evaluated by Polish adaptation of the Intelligence and Development Scales (IDS) performed by trained psychologists. Results Urinary BPA concentrations and back-calculated daily intakes (medians of 1.8 μg/l and 46.3 ng/kg bw/day, respectively) were similar to other European studies. Urinary cotinine levels and body mass index, together with maternal educational level and socio-economic status, were the main determinants of BPA levels in Polish children. After adjusting for confounding factors, BPA has been found to be positively associated with emotional symptoms (β: 0.14, 95% CI: 0.022; 0.27). Cognitive and psychomotor development were not found to be related to BPA levels. Conclusions This study represents the first report of BPA levels and their determinants in school age children in Poland. The exposure level was found to be related to child emotional condition, which can have long-term consequences including social functioning and scholastic achievements. Further monitoring of this population in terms of overall chemical exposure is required.

Published
2021
Full Text
View/download PDF

2. Correction: Human-Biomonitoring derived exposure and Daily Intakes of Bisphenol A and their associations with neurodevelopmental outcomes among children of the Polish Mother and Child Cohort Study

Author

Mercè Garí, Rebecca Moos, Daniel Bury, Monika Kasper-Sonnenberg, Agnieszka Jankowska, Aleksandra Andysz, Wojciech Hanke, Dennis Nowak, Stephan Bose-O’Reilly, Holger M. Koch, and Kinga Polańska

Subjects
Industrial medicine. Industrial hygiene, RC963-969, Public aspects of medicine, RA1-1270
Published
2023
Full Text
View/download PDF

4. Quantitative matrix-assisted laser desorption ionization-time-of-flight mass spectrometry analysis of synthetic polymers and peptides

Author

Lukas Hyzak, Friederike von Rath, Siegmar Gäb, Oliver J. Schmitz, Michaela Wirtz, Rebecca Moos, David Melchior, Michael Köhler, Volker Wulf, and Hans-Willi Kling

Subjects
MALDI imaging, chemistry.chemical_classification, Analyte, Chromatography, Maltosides, Polymers, Analytical chemistry, Chemie, Polymer, Mass spectrometry, Stainless Steel, Analytical Chemistry, law.invention, chemistry.chemical_compound, Raffinose, chemistry, law, Ionization, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Crystallization, Peptides, Quantitative analysis (chemistry)
Abstract

Matrix-assisted laser desorption ionization (MALDI) is a very powerful and widely used mass spectrometric technique to ionize high molecular weight compounds. The most commonly used dried droplet (DD) technique can lead to a concentration distribution of the analyte on the target and is therefore often not suitable for reproducible analyses. We developed a new solvent-free deposition technique, called compressed sample (CS), to prevent the distribution of the analytes caused by the crystallization of the compounds. The CS technique presented in this work allows the quantitative analysis of synthetic polymers such as derivatized maltosides with correlation coefficients of 0.999 and peptides up to 3500 Da with correlation coefficients of at least 0.982 without the use of stable-isotope-labeled standards.

Published
2011

Catalog

Books, media, physical & digital resources
See catalog results