Search

This essay examines the ways that controversial texts were read by reader-critics who sought to engage with their reading in new ways in the eighteenth century. It takes as its primary example An Apology for the Life of George Anne Bellamy (1785), the autobiography of a woman actor in mid-eighteenth-century Britain. Bellamy was praised for her sentiment but criticized for her representation of facts, despite the fact that where her descriptions can be corroborated they are generally accurate. In addition to examining published critical reactions, this essay looks in depth at the annotations of two early readers in a surviving copy of the book to document how hostile readers read works like Bellamy's Apology in order to judge, correct, or otherwise speak back to the author in a kind of dialogue. This essay suggests that women writers like Bellamy were particularly susceptible to the hostile reader because of more general distrust of women as reporters of fact, and that hostile readers were particularly interested in controversial texts that prompted engagement. [ABSTRACT FROM AUTHOR]

Copyright of Publishing Journal is the property of Wuhan University, School of Information Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Solid cancers constitute a tremendous burden on global healthcare, requiring a deeper understanding of the molecular mechanisms underlying cancer development and progression. Epigenetic changes, notably N6-methyladenosine (m6A) RNA methylation, have emerged as important contributors to the biology of solid tumors in recent years. This epigenetic mark dynamically affects gene expression at the post-transcriptional level and modulates a variety of cellular processes, making it a focus of research in the context of solid tumors. m6A modification patterns are dysregulated in a variety of solid cancers, including ovarian, breast, lung, colorectal, pancreatic, and others. This dysregulated m6A landscape has been shown to induce significant changes in the expression of oncogenes, tumor suppressors, and genes involved in cancer stem cells, metastasis, and treatment resistance. In solid tumors, the interaction of m6A "writers" (e.g., METTL3, METTL14, and others), "erasers" (e.g., ALKBH5, FTO), and "readers" (e.g., members of YTHDF proteins and others) delicately changes the m6A methylome. Targeting m6A regulators as a potential therapeutic method to control gene expression and prevent tumor development seems a novel strategy. To enhance treatment results, advances in this area of research have led to the development of targeted treatments aiming at restoring or altering m6A alteration patterns in solid tumors. [ABSTRACT FROM AUTHOR]

Literary reading is under transformation. Digital devices supplement traditional paper books with e-books and audiobooks, and at the same time, ubiquitous digital connection challenges focused reading. Based on a qualitative interview study with adult leisure readers, this article explores how affordances offered by digital technologies influence reading habits. Informants demonstrate how e-books and audiobooks enhance reading experiences, as digital affordances influence the how and the when of literary consumption. Three prominent findings are stated. (1) Readers adapt reading mode to the situation, and experienced readers have developed strategies to maximise the ultimate combination of title, format and reading conditions. (2) Digital reading favours lighter texts. This dimension is more substantial for audiobooks, relating to the wide choice of combining audiobooks with other activities. (3) Being devoted readers motivates people to develop strategies to ensure further reading. These strategies effectively make readers practically and temporally disconnect to immerse in literature. [ABSTRACT FROM AUTHOR]

RNA modification is an essential component of the epitranscriptome, regulating RNA metabolism and cellular functions. Several types of RNA modifications have been identified to date; they include N6-methyladenosine (m6A), N1-methyladenosine (m1A), 5-methylcytosine (m5C), N7-methylguanosine (m7G), N6,2′-O-dimethyladenosine (m6Am), N4-acetylcytidine (ac4C), etc. RNA modifications, mediated by regulators including writers, erasers, and readers, are associated with carcinogenesis, tumor microenvironment, metabolic reprogramming, immunosuppression, immunotherapy, chemotherapy, etc. A novel perspective indicates that regulatory subunits and post-translational modifications (PTMs) are involved in the regulation of writer, eraser, and reader functions in mediating RNA modifications, tumorigenesis, and anticancer therapy. In this review, we summarize the advances made in the knowledge of different RNA modifications (especially m6A) and focus on RNA modification regulators with functions modulated by a series of factors in cancer, including regulatory subunits (proteins, noncoding RNA or peptides encoded by long noncoding RNA) and PTMs (acetylation, SUMOylation, lactylation, phosphorylation, etc.). We also delineate the relationship between RNA modification regulator functions and carcinogenesis or cancer progression. Additionally, inhibitors that target RNA modification regulators for anticancer therapy and their synergistic effect combined with immunotherapy or chemotherapy are discussed. [ABSTRACT FROM AUTHOR]

This article reviews three books and uses these as motivation to consider the changing conditions for the discourse communities which define musicology and its companion disciplines. More specifically, the books inspire a re-evaluation of the contemporary conditions of musical experience, activity, and research in a digitally oriented sound–word publishing world. The article notes a growing body of disciplinary literature that interacts with, or presumes, the presence of a particular readership that not only reads, but actively listens, while reading. It encourages a more aurally directed way of writing and suggests that musicology and its companion disciplines should continue to explore more coherent ways to link words to music. [ABSTRACT FROM AUTHOR]

Cancer treatment has always been a challenge for humanity. The inadequacies of current technologies underscore the limitations of our efforts against this disease. Nevertheless, the advent of targeted therapy has introduced a promising avenue, furnishing us with more efficacious tools. Consequently, researchers have turned their attention toward epigenetics, offering a novel perspective in this realm. The investigation of epigenetics has brought RNA readers to the forefront, as they play pivotal roles in recognizing and regulating RNA functions. Recently, the development of inhibitors targeting these RNA readers has emerged as a focal point in research and holds promise for further strides in targeted therapy. In this review, we comprehensively summarize various types of inhibitors targeting RNA readers, including non-coding RNA (ncRNA) inhibitors, small-molecule inhibitors, and other potential inhibitors. We systematically elucidate their mechanisms in suppressing cancer progression by inhibiting readers, aiming to present inhibitors of readers at the current stage and provide more insights into the development of anticancer drugs. [ABSTRACT FROM AUTHOR]

Copyright of Revista Didasc@lia: Didáctica y Educación is the property of Universitaria de Las Tunas, Centro de Estudios de Didactica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Strategic Universe Journal / Univers Strategic is the property of Dimitrie Cantemir Christian University, Institute for Security Studies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In 2016, Beninese police moved onto the university campus in Abomey-Calavi to control the violent student demonstrations which led to the invalidation of the 2015-16 academic year in the Faculté des Lettres, Arts et Sciences Humaines and the turmoil that turn of events subsequently risked causing. This local form of censorship was amplified by nationwide breaches of freedom of speech and opinion. How did the university react to all this? Certain teachers and students used educational activities as a pretext for overcoming the drastic restrictions to their freedoms. This article argues that the analysis of purposefully selected dramatic fiction can be employed in the critique of genuine infringements to freedom, and also in the identification of ways in which individuals overcome those infringements. Participant observation and the concept known as the "Horizon of Social Expectation" are applied to dramaturgical texts. The first part of the article provides a brief description of the political context, the strategic positioning of contributors and their respective levels of involvement in the pedagogical experience. This contextualisation then leads to the second part: a presentation of the results of the analysis conducted on paratextual data and the two dramaturgical categories of the theatrical text itself. [ABSTRACT FROM AUTHOR]

The Romanian migration of the last decades has generated in the world, but especially in Europe, a significant population of Romanian origin, but far from the cultural sources in Romania. The appearance of activities that would bring together the Romanian community appeared inevitable; among them, the initiatives of some Romanian libraries were born naturally, in various forms, sometimes structured on local public libraries or just as personal initiatives. The present article maps and evaluates several European cases of Romanian libraries: three in the Kingdom of the Netherlands and one in Prague, which already has countless branches, especially in the European Union. The investigation shows a strong connection between the Romanian libraries and their communities, especially with the parents of minor children, and a strong appreciation of these libraries' educational and social impact. [ABSTRACT FROM AUTHOR]

The purpose of this article is to clarify the evolving connotations of “readers” and “books” in public libraries, centers on a thriving segment of library patrons – minor readers. Taking the services for minors in Guangdong China as an example, the study examines and discusses how public libraries can play a proactive role in forging effective connections between readers and books, hence promoting the sustainable development of library services. The author has come to the conclusion that public libraries worldwide must proactively adapt to the ever-evolving environment, cutting-edge technologies, and emerging information needs.

This paper reports on how 92 parochial incumbents, 80 assistant clergy, and 94 Readers in the dioceses of Exeter and Truro rated the importance of various tasks in their ministries, how well they felt equipped to do those tasks, and their priorities for ministry and training. Preaching, leading worship, and pastoral care were rated as most important, while management and administration, talking about giving and raising money, and speaking up on local issues were rated as least important. The largest gaps between importance of a task and being equipped for it were supporting personal wellbeing for incumbents, equipping disciples for assistant clergy, and bringing others to faith for Readers. Top ministry priorities were equipping lay ministries, team working, and supporting evangelists; lowest priorities were remaining faithful to received traditions, maintaining the parish system, and developing digital ministries. [ABSTRACT FROM AUTHOR]

The aim of this research is to introduce the famous readers in Egypt from the beginning of the fifth century Hijri to the end of the seventh century Hijri, and to classify them into categories to assist those looking for biographies of prominent readers over different periods and regions. The research problem lies in the challenge of collecting biographical information about readers from biographical and categorization books, individually extracting readers of each region of Egypt, and then ordering them by time which would require a considerable amount of time and effort. Therefore, it was decided to present biographies of readers based on a specific time period and location, using biographical books of readers and their categories. The importance of the research lies in studying the categories of famous readers in Egypt, explaining their circumstances, biographies, and highlighting the distinct features of the recitation movement in Egypt. The research methodology follows a historical-inductive approach in arranging the biographies of readers, focusing on prominent readers of the Egyptian school from the beginning of the fifth century Hijri until the end of the seventh century Hijri, and attributing them to the regions they resided in, visited, taught in, or traveled to. The research is organized into an introduction and a preface that define categories, readers, reciters, and the school, divided into two chapters. The first chapter delves into the introduction of recitation in Egypt, its spread, its influence on and by other schools, prevalent narrations in Egypt since the Islamic era. The second chapter presents the categories of readers of the Egyptian school from the beginning of the fifth century Hijri to the end of the seventh century Hijri, and concludes with the scientific output of readers in Egypt during this period. The study closes with conclusions, such as the Egyptians' keenness on receiving and reciting the Quran since the advent of Islam in Egypt, the significant impact of prominent reciters like Warsh in establishing the Egyptian school, documenting its relationships with other schools, and the esteemed status of the Egyptian school due to its distinguished figures who devoted their lives to serving the Quran and its sciences. Finally, the research ends with recommendations, emphasizing the importance of scholars' interest in the science of readers' categories in various countries and across different eras. Furthermore, it recommends dedicating more studies and research to this field. The research includes an index of sources, references, and a subject index. [ABSTRACT FROM AUTHOR]

This article traces the conceptual origins of Newton's draft scholia to Propositions IV through IX of Book III of the Principia to a manuscript booklet of observational data. By coordinating passages marked by dog-eared pages in Newton's books with his correspondence and working papers, it is possible to date these references to a time when he was still actively working on the Principia itself. This provides the basis for a new interpretation of Newton's uses of Egyptian and Graeco-Roman antiquity to counter rival histories of astronomy and philosophy influenced by Descartes. [ABSTRACT FROM AUTHOR]

Copyright of Álabe is the property of Alabe and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Sosiologia is the property of Westermarck Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This research sought to discover how readers of crime fiction novels interact with these texts utilizing a co-creative lens. A qualitative online survey was conducted on three popular crime fiction websites and the responses were analyzed using thematic analysis. It was found that, in contrast to prior research, crime fiction novel readers do not simply view crime fiction as a puzzle to be solved. Instead, they place a high degree of importance on the substantive elements of the fiction such as the quality and details of the plot, setting, and the characters constructed by the author. These findings indicate that crime fiction novel authors should note that their readers desire a more general and pleasurable reading experience than was previously thought. [ABSTRACT FROM AUTHOR]

This study applies Carolin Gebauer's theory of fictional present to short fiction, focusing on Alice Munro's "In sight of the lake" (2012) which is rendered in present-tense narration. Gebauer identifies immersive, rhetoric, communicative, and synchronizing functions for the use of present tense in narratives. The paper investigates how all these contribute to the thematic function. It detects instabilities on the story level (between characters) and tensions on the discourse level(between text and readers).The examination of generic, narratological, rhetoric, and affective tensions in Munro's story reveals the cognitive operations that fictional present activates in the mind of readers and thereby ironizes their social imaginary of the fourth age. [ABSTRACT FROM AUTHOR]

Background: Over-the-counter (OTC) diagnostic testing is on the rise with many in vitro diagnostic tests being lateral flow assays (LFAs). A growing number of these are adopting reader technologies, which provides an alternative to visual readouts for results interpretation, allowing for improved accessibility of OTC diagnostics. As the reader technology market develops, there are many technologies entering the market, but no clear, single solution has yet been identified. The purpose of this research is to identify and discuss important parameters for the assessment of LFA reader technologies for consideration by manufacturers or researchers. Methods: As part of The National Institute of Biomedical Imaging and Bioengineering's Rapid Acceleration of Diagnostics (RADx) Tech program, reader manufacturers were interviewed to investigate the current state of reader technology development through several parameters identified as important industry standards. Readers were categorized by technology type and parameters including cost, detection method, multiplex capabilities, assay type, maturity, and use case were all assessed. Results: Fifteen reader manufacturers were identified and interviewed, and information on a total of 19 technologies was assessed. Reader technology type was found to be predictive of other attributes, whether the reader is smart technology only, a standalone reader, a reader with smart technology required, or a reader with smart technology optional. Conclusions: Pairing reader technology with OTC diagnostic tests is important for improving existing COVID-19 tests and can be utilized in other diagnostics as the OTC use case grows in popularity. Reader technology type, which is predictive of core reader attributes, should be considered when selecting a reader technology for a specific LFA test within the context of regulatory guidance. As diagnostics increase in complexity, readers provide solutions to accessibility challenges, facilitate public health reporting, and ease the transition to multiplex testing, therefore increasing market availability.

Abstract N1-methyladenosine (m1A) is a post-transcriptionally modified RNA molecule that plays a pivotal role in the regulation of various biological functions and activities. Especially in cancer cell invasion, proliferation and cell cycle regulation. Over recent years, there has been a burgeoning interest in investigating the m1A modification of RNA. Most studies have focused on the regulation of m1A in cancer enrichment areas and different regions. This review provides a comprehensive overview of the methodologies employed for the detection of m1A modification. Furthermore, this review delves into the key players in m1A modification, known as the “writers,” “erasers,” and “readers.” m1A modification is modified by the m1A methyltransferases, or writers, such as TRMT6, TRMT61A, TRMT61B, TRMT10C, NML, and, removed by the demethylases, or erasers, including FTO and ALKBH1, ALKBH3. It is recognized by m1A-binding proteins YTHDF1, TYHDF2, TYHDF3, and TYHDC1, also known as “readers”. Additionally, we explore the intricate relationship between m1A modification and its regulators and their implications for the development and progression of specific types of cancer, we discuss how m1A modification can potentially facilitate the discovery of novel approaches for cancer diagnosis, treatment, and prognosis. Our summary of m1A methylated adenosine modification detection methods and regulatory mechanisms in various cancers provides useful insights for cancer diagnosis, treatment, and prognosis. Video Abstract

The article uses and develops the ideas of the famous literary historian M. Zerov, which relate to Ukrainian sentimentalism. His experience in the scientific interpretation of G. Kvitka's work made it possible to determine ways of optimally engaging the possibilities of literary life to reveal the influence of such social factors as charity, women's education and upbringing, on the writer's creative practice. The relevance of the outlined approach is due to the need to overcome simplification in the understanding of our classical cultural heritage, the need to clarify knowledge about Ukrainian sentimentalism by expanding the scope of researched facts and their objective study. On the basis of the analysis of biographical and cultural-aesthetic material, the motives that guided the Ukrainian sentimentalist were identified and described, as well as his worldview and aesthetic priorities were clarified. Biographical facts were analyzed separately, testifying to G. Kvitka's special interest in the organization of the women's institute in Kharkiv and his awareness of the need for literary texts that would meet the aesthetic demands of the institute's female students. Some attention is paid to clarifying the dependence of the writer on the notions of sentimentalism concerning the criteria of "truthfulness" of an artistic work. It is pointed out the groundlessness of involving Kvitka's prose in realism, as some Soviet researchers and their followers once tried to do. The hypothesis is proposed, according to which H. Kvitka's sentimental prose appeared precisely as an organic continuation and development of his charitable and educational work, the kinship of these types of activities is separately substantiated, and their common ideological basis is emphasized. The role of H. Kvitka in the formation of the Ukrainian female readership was noted, features of his works that contributed to this are highlighted. As a perspective for further studies, it is proposed to find out exactly how the literary and spiritual heritage of sentimentalism is presented in the modern cultural life of Ukrainians.

BJPsych Bulletin was first established as the Bulletin of the Royal College of Psychiatrists in 1977. Since then, it has extended its influence within the field, and it is now the go-to journal for practical clinical considerations in psychiatry, and mental health more widely. It stands together with the wider family of RCPsych journals – BJPsych, BJPsych Advances, BJPsych Open and BJPsych International – and offers a number of distinct advantages for readers and authors. I commend it to you.

Ding Mo is a prolific online female writer, whose works involve themes such as suspense love, science fiction, romance, and the workplace, with suspense love as the main focus. Ding Mo, an online writer with a background in science and engineering, has always adhered to the original intention of "writing should always have a fragrance of ink". Her works are characterized by outstanding writing style, natural plot, and special attention to detail setting and atmosphere enhancement. Her creation also adheres to the purpose of "making works closer to the local style of China", and her works are popular among readers due to their strong sense of reality. As a platinum writer of the Reading Group, Ding Mo has always focused on and paid attention to the development of Chinese online literature, believing that "middle-level and new writers are the future of online literature", which reflects the expectations and concern of a senior online writer for the growth of young writers. [ABSTRACT FROM AUTHOR]

N1-methyladenosine (m1A) is a post-transcriptionally modified RNA molecule that plays a pivotal role in the regulation of various biological functions and activities. Especially in cancer cell invasion, proliferation and cell cycle regulation. Over recent years, there has been a burgeoning interest in investigating the m1A modification of RNA. Most studies have focused on the regulation of m1A in cancer enrichment areas and different regions. This review provides a comprehensive overview of the methodologies employed for the detection of m1A modification. Furthermore, this review delves into the key players in m1A modification, known as the "writers," "erasers," and "readers." m1A modification is modified by the m1A methyltransferases, or writers, such as TRMT6, TRMT61A, TRMT61B, TRMT10C, NML, and, removed by the demethylases, or erasers, including FTO and ALKBH1, ALKBH3. It is recognized by m1A-binding proteins YTHDF1, TYHDF2, TYHDF3, and TYHDC1, also known as "readers". Additionally, we explore the intricate relationship between m1A modification and its regulators and their implications for the development and progression of specific types of cancer, we discuss how m1A modification can potentially facilitate the discovery of novel approaches for cancer diagnosis, treatment, and prognosis. Our summary of m1A methylated adenosine modification detection methods and regulatory mechanisms in various cancers provides useful insights for cancer diagnosis, treatment, and prognosis. Cgy29QUiz7vJ-gsCtujnZr Video Abstract [ABSTRACT FROM AUTHOR]

Between 1910 and 1912, La Buena Lectura was published. It was a newspaper from Antioquia funded by the Sociedad de San Vicente de Paul. On its pages emerge reading protocols that search for the conquest of public reason by Catholicism. As a result, an interpretative community of intellectual people arose educating a lector community to read without affection or emotion and with a high sense of duty. This use of reading takes structural components from catechism and materializes without doubt as a fundamental moment in the history of the practices and the formation of readers in Colombia. [ABSTRACT FROM AUTHOR]

This article attempts to identify Hobbes's reading and understanding of Plato's writings by looking at the first seven direct references to Platonic dialogues in the Hobbesian corpus, which range from 1629–42, including Hobbes's unpublished manuscript writings. By analysing these references it is determined that Hobbes is likely to have had first hand knowledge of Plato, from a Latin and/or Greek edition of Plato's complete works. The references to Plato's works in Hobbes's writings are eclectic and philological for the most part, and serve to demonstrate the depth and range of his reading of Plato. It is only by 1642 that Hobbes makes a clear statement of his commitment to a Platonic principle, viz. that knowledge is memory. In the second half of the article I shall then argue that this principle is a foundational aspect of Hobbes's philosophy, and that its Platonic origins thus help us to understand both Hobbes's philosophical system and the different ways in which an "Oxford Platonism" emerged in the seventeenth century. [ABSTRACT FROM AUTHOR]

Copyright of Jurisprudence Faculty Journal / Magallaẗ Kulliyyaẗ Al-fiqh is the property of Republic of Iraq Ministry of Higher Education & Scientific Research (MOHESR) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Álabe is the property of Alabe and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

On holidays and weekends, we can notice a large rush at shopping centres in metro areas. This is exacerbated when there are substantial discounts and deals. By applying the notion of internet of thing (IoT) for concerning all things in the grocery store, an automated smart shopping system is created. Each product within such scheme had an economical radio frequency identification (RFID) tag positioned with it. Once an item has been added to a smart cart, the information about the merchandise is quickly read by the RFID reader on the cart. The outcome is, direct invoicing is done out from shopping cart, saving clients from having to wait in a long line at the checkout. The product's expiration date is also displayed and broken products can be determined by their weight. As a result, expired and damaged products will not be taken into account when calculating the cost. Furthermore, this system gains the addition of smart shelves incorporating RFID readers which may check stock and possibly update a central server. Inventory control becomes simpler as a result. Finally, cashier stations could verify a customer's purchase. As a result, billing may be done right in the trolley, saving clients a lot of time. [ABSTRACT FROM AUTHOR]

Cancer treatment has always been a challenge for humanity. The inadequacies of current technologies underscore the limitations of our efforts against this disease. Nevertheless, the advent of targeted therapy has introduced a promising avenue, furnishing us with more efficacious tools. Consequently, researchers have turned their attention toward epigenetics, offering a novel perspective in this realm. The investigation of epigenetics has brought RNA readers to the forefront, as they play pivotal roles in recognizing and regulating RNA functions. Recently, the development of inhibitors targeting these RNA readers has emerged as a focal point in research and holds promise for further strides in targeted therapy. In this review, we comprehensively summarize various types of inhibitors targeting RNA readers, including non-coding RNA (ncRNA) inhibitors, small-molecule inhibitors, and other potential inhibitors. We systematically elucidate their mechanisms in suppressing cancer progression by inhibiting readers, aiming to present inhibitors of readers at the current stage and provide more insights into the development of anticancer drugs.

The digital transformation has revolutionized the media industry, reshaping the way news is consumed and challenging the dominance of traditional printed publications. As technology continues to advance at an unprecedented pace, it is crucial to examine the evolving landscape of news publishing and understand the preferences and behaviors of readers in the context of digital and printed newspaper formats. This research article presents a comparative analysis of reader opinions on a significant Croatian e-publication over a five-year period, aiming to explore the impact of digital transformation on readers' perceptions, engagement, and preferences between online and traditional printed content. By delving into the advantages, challenges, and trends associated with e-publications and printed editions, this study provides valuable insights into the dynamic relationship between readers and news publications in the digital era. [ABSTRACT FROM AUTHOR]

In this short piece, I want to reflect on the status, relevance and future of the academic journal. They emerged at a point when middle class European men were beginning to produce a cumulative body of knowledge using paper technologies, editorial boards and professional associations to legitimate their discoveries. Three hundred years later, the global university system, the financial interests of global knowledge corporations, and the occupational interests of university workers has supported a huge explosion of journals as markers of status, providers of data about who writes and who cites, and profitable ways of extracting value from university library budgets. This journal, though it has published much which is critical about such a system, is entirely parasitic on this set of financial and occupational interests. As Organization enters its fourth decade, might it be possible to be clearer concerning what services it provides and for who? If we think of it, as my mother-in-law once presciently suggested, as a magazine, can we be more explicit about what stories and features we are selling, and who our readers are? In other words, should we try to be more magazine? [ABSTRACT FROM AUTHOR]

Derek Pearsall wrote influentially about the contexts in which Middle English romances were transmitted, paying particular attention to large manuscript "libraries" offering mixed edification and diversion. Two copies of Sir Orfeo, a romance in which he was especially interested, survive in just such contexts, in capacious anthologies. The third copy, however, in London, British Library MS Harley 3810, section I, is rather different, and has attracted less attention. This article discusses the features of this section of Harley 3810, its relationship to the other sections of the manuscript, and what can be hypothesized about its early readership and circulation. Unlike the other manuscripts in which Sir Orfeo appears, this small-format anthology has the characteristics of a pocket-book. [ABSTRACT FROM AUTHOR]

Esophageal carcinoma (EC) is always diagnosed at advanced stage and its the mortality rate remains high. The patients usually miss the best opportunity for treatment because of non-specific symptoms and the survival rates are low. N6-methyladenosine (m6A) the predominant modification in eukaryotic messenger RNA(mRNA), serves vital roles in numerous bioprocess. This chemical modification is dynamic, reversible and consists of three regulators: m6A methyltransferases (writers), demethylases (erasers) and m6A-binding proteins (readers). Recently, a growing number of evidences have indicated relationships between m6A and EC. Whereas, lacking of cognition about the molecular mechanism of m6A modification in esophageal carcinoma. We will focus on the biological function roles of m6A modification in the tumorigenesis and development of EC. Recent studies showed that immunotherapy had a positive impact on EC. The relationship between m6A and immunotherapy in EC deserves further research and discussion. We will also discuss the potential clinical applications regarding diagnosis, treatment and prognosis of m6A modification for EC and provide perspectives for further studies. [ABSTRACT FROM AUTHOR]

Based on lurking observation on profiles and channels of four literary influencers, the aim of this article is to analyze some discourses about readers' preferences and experiences regarding reading supports. The flexibility of these subjects is observed, as they read both in print and digitally, recognizing both advantages and disadvantages. However, even though they are digital natives, they show a special interest in print, upon a relationship of affection, consumption and the search to leave reading experiences traces in the printed object. [ABSTRACT FROM AUTHOR]