280 results on '"Reade, M"'
Search Results
2. The Australian defence force medical specialist program: Past, present and future
- Author
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Mahoney, Adam John, Reade, M, Young, I, Butson, B, Storey, A, and Bender, K
- Published
- 2022
3. Autologous fresh whole blood transfusion training - a narrative review and report of u.S. Military experience
- Author
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Chan, D L, Fritz, D, Nessler, T, Santoy, L, Peterson, W, and Reade, M
- Published
- 2023
4. The Most Important Questions in the Current Practice of Transfusion of Critically Bleeding Patients
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Flint, A. W., Winearls, J., Reade, M. C., and Vincent, Jean-Louis, Series Editor
- Published
- 2023
- Full Text
- View/download PDF
5. Whose side are you on?: Complexities arising from the non-combatant status of military medical personnel
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Reade, M C
- Published
- 2023
6. Nebulized Therapeutics for COVID-19 Pneumonia in Critical Care
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Dhanani, J., Reade, M. C., and Vincent, Jean-Louis, Series Editor
- Published
- 2022
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7. Developing a grounded theory for interprofessional collaboration acquisition using facilitator and actor perspectives in simulated wilderness medical emergencies
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Smith, H A, Reade, M, Maar, M, and Jeeves, N
- Published
- 2017
8. Evaluating Quality in Trauma Systems
- Author
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Mahoney, A. J., Reade, M. C., and Vincent, Jean-Louis, Series Editor
- Published
- 2020
- Full Text
- View/download PDF
9. Intracranial pressure monitoring in patients with acute brain injury in the intensive care unit (SYNAPSE-ICU): an international, prospective observational cohort study
- Author
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Abdelaty, M., Abed Maillard, S., Ahmed, H., Albrecht, L., Alsudani, A., Amundarain, E.D., Anand, S., Andersen, J.B., Anglada, M., Arabi, Y, Aragao, I., Arias Verdu, M.D., Asehnoune, K., Assunção, F., Audibert, G., Badenes, R., Bajracharya, T., Banco, P., Batista, D., Bertellini, E., Berty Gutiérrez, H., Besch, G., Biston, P., Blandino Ortiz, A., Blazquez, V., Bloria, S., Bonetti, C., Bresil, P., Brunetti, I., Buldini, V., Caillard, A., Calamai, I., Carbonara, M., Caricato, A., Casadio, M.C., Casanova, M., Cavaleiro, P., Celaya Lopez, M., Chan, C.Y., Chauhan, R., Cinotti, R., Corral, L., Cortegiani, A., Cotoia, A., Crippa, I.A., Davidovich, V., Del Bianco, S., Diakaki, C., Dibu, J., Dimoula, A., Domeniconi, G., Dominguez, L.J.Y., Dovbysh, N., Duque, P., Eddelien, H.S., Efthymiou, A., Egmose Larsen, T., Elhadi, M., Favre Eva, E., Fencl, M., Forjan, P., Freitas, R., Fuest, K., Fumale, M., Gakuba, C., Galarza, L., García, M.F., Gasca López, G.A., Gelormini, C., Gempeler, A., Giannopoulos, A., Giménez, M.E., Giugni, A., Glorieux, D., Gonzalez Perez, M.I., Gradisek, P., Grandis, M., Griesdale, D., Gritsan, A., Grotheer, S., Gupta, D., Hallt, E.D., Hawthorne, C., Helbok, R., Holm, M.O., Iasonidou, C., Idowu, O., Ioannoni, E., Izzi, A., Jibaja, M., Kafle, P., Kandamby, D.H., Khan, M.M., Khomiakov, S., Kilapong, B., Kletecka, J., Kojder, K., Kolias, A., Kontoudaki, E., Koukoulitsios, G., Kovac, N., Kozar, S., Krieg, S.M., Kurtz, P., Kyriazopoulos, G., Lamperti, M., Lavicka, P., Lencastre, L., Levin, M., Lightfoot, R., Lindner, A., López Ojeda, P., Lores, A., Lucca, M., Luthra, A., Magni, F., Majholm, B., Makris, D., Maldonado, F., Marudi, A., Maskey, S., Mebis, L., Mejia-Mantilla, J.H., Mendoza, R., Milivojevic, N., Miroz, J.P., Monleon, B., Montes, J.M., Morelli, P., Motta, A., Mouloudi, E., Muehlschlegel, S., Ñamendys Silva, S.A., Nardai, G., Nilam, K., Olson, D., Ozair, A., Pacheco, C., Padilla Juan, J., Palli, E., Panda, N., Pantelas, N., Pariente, L., Pearson, D., Pérez-Araos, R., Picetti, E., Pinedo Portilla, J.L., Pons, B., Pozzi, F., Provaznikova, E., Quartarone, M.C., Quintard, H., Rajbanshi, L., Reade, M., Ribaric, S.F., Rigamonti, A., Rivera, L.L., Roberts, J., Roka, Y.B., Sabelnikovs, O., Sapra, H., Schaller, S.J., Sekhon, M., Sellami, W., Seppelt, I., Serrano, A., Sharma, K., Shrestha, G.S., Shum, H.P., Silva, S., Simoes, M., Sivakumar, S., Siviter, R., Skola, J., Škoti, M., Smitt, M., Soley, R., Sonneville, R., Soragni, A., Soyer, B., Spatenkova, V., Stamou, E.E., Stival, E., Olson, Z., Tánczos, K., Thompson, C., Thomsen, J., Tsikriki, S., Van De Velde, S., Videtta, W., Villa, F., Vrbica, K., Vrettou, C., Westy Hoffmeyer, H., Wolf, S., Yasin Wayhs, S., Zerbi, S.M., Robba, Chiara, Graziano, Francesca, Rebora, Paola, Elli, Francesca, Giussani, Carlo, Oddo, Mauro, Meyfroidt, Geert, Helbok, Raimund, Taccone, Fabio S, Prisco, Lara, Vincent, Jean-Louis, Suarez, Jose I, Stocchetti, Nino, and Citerio, Giuseppe
- Published
- 2021
- Full Text
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10. Resuscitation Fluid Choices to Preserve the Endothelial Glycocalyx
- Author
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Milford, E. M., Reade, M. C., and Vincent, Jean-Louis, Series Editor
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- 2019
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11. Central α2-adrenoreceptor Agonists in Intensive Care
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Liu, D., Reade, M. C., and Vincent, Jean-Louis, editor
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- 2018
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12. Making the Best Use of Simulation Training in Critical Care Medicine
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Mahoney, A., Vassiliadis, J., Reade, M. C., and Vincent, Jean-Louis, editor
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- 2017
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13. Application of clinical governance in a role 2E hospital: The 2nd General Health Battalion experience
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Linwood, R, Duff, N, Flint, C, Reade, M, Krohn, P, Williams, A, and McCall, B
- Published
- 2017
14. Optimal Temperature Management in Trauma: Warm, Cool or In-between?
- Author
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Reade, M. C., Lumsden-Steel, M., and Vincent, Jean-Louis, editor
- Published
- 2015
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15. Dexmedetomidine and Propofol Sedation in Critically Ill Patients and Dose-associated 90-Day Mortality: A Secondary Cohort Analysis of a Randomized Controlled Trial (SPICE III)
- Author
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Shehabi, Yahya, primary, Serpa Neto, Ary, additional, Bellomo, Rinaldo, additional, Howe, Belinda D., additional, Arabi, Yaseen M., additional, Bailey, Michael, additional, Bass, Frances E., additional, Bin Kadiman, Suhaini, additional, McArthur, Colin J., additional, Reade, Michael C., additional, Seppelt, Ian M., additional, Takala, Jukka, additional, Wise, Matt P., additional, Webb, Steve A., additional, Mashonganyika, C., additional, McKee, H., additional, Tonks, A., additional, Donnelly, A., additional, Hemmings, N., additional, O’Kane, S., additional, Blakemore, A., additional, Butler, M., additional, Cowdrey, K., additional, Dalton, J., additional, Gilder, E., additional, Long, S., additional, McCarthy, L., additional, McGuinness, S., additional, Parke, R., additional, Chen, Y., additional, McArthur, C., additional, McConnochie, R., additional, Newby, L., additional, Bellomo, R., additional, Eastwood, G., additional, Peck, L., additional, Young, H., additional, Boschert, C., additional, Edington, J., additional, Fletcher, J., additional, Smith, J., additional, Nand, K., additional, Raza, A., additional, Sara, T., additional, Bennett-Britton, J., additional, Bewley, J., additional, Bodenham, V., additional, Cole, L., additional, Driver, K., additional, Grimmer, L., additional, Howie, L., additional, Searles, C., additional, Sweet, K., additional, Webster, D., additional, van Berkel, A., additional, Connor, H., additional, Dennett, J., additional, van Der Graaff, M., additional, Henderson, S., additional, Mehrtens, J., additional, Miller, K., additional, Minto, E., additional, Morris, A., additional, Noble, S., additional, Parker, K., additional, Bulfin, L., additional, Hart, N., additional, Shepherd, K., additional, Vij, S., additional, Dickson, S., additional, Elloway, E., additional, Ferguson, C., additional, Jackson, R., additional, MacNaughton, P., additional, Marner, M., additional, Squire, R., additional, Waddy, S., additional, Wafer, P., additional, Welbourne, J., additional, Ashcroft, P., additional, Chambler, D., additional, Dukes, S., additional, Harris, A., additional, Horton, S., additional, Sharpe, S., additional, Williams, P., additional, Williams, S., additional, Bailey, M., additional, Blazquez, E., additional, France, D., additional, Hutchison, R., additional, O’Connor, A., additional, Comadira, G., additional, Gough, M., additional, Tallott, M., additional, Bastick, M., additional, Cameron, R., additional, Donovan, S., additional, Ellis, K., additional, Gaur, A., additional, Gregory, R., additional, Naumoff, J., additional, Turner, E., additional, White, M., additional, Au, K. F. J., additional, Fratzia, J., additional, Treloar, S., additional, Lim, C. H., additional, Maseeda, Y., additional, Tan, A. P., additional, Tang, C. L., additional, Yong, C. Y., additional, Akaltan, M., additional, Berger, S., additional, Blaser, D., additional, Fazlija, L., additional, Jong, M. L., additional, Lensch, M., additional, Ludwig, R., additional, Merz, T., additional, Nettelbeck, K., additional, Roth, M., additional, Schafer, M., additional, Takala, J., additional, Wehr, A., additional, Zacharias, D., additional, Amran, R., additional, Ashraf, H. N., additional, Azmi, N., additional, Basri, N., additional, Burhanuddin, H., additional, Hadinata, Y., additional, Hamdan, A., additional, Kadiman, S., additional, Rashid, A. I. Y. M., additional, Sabran, I. N., additional, Sulaiman, S., additional, Zabidi, I. N., additional, Al-Dawood, A., additional, Aljuaid, M., additional, Anizi, H. Al, additional, Saeedi, A. Al, additional, Arabi, Y., additional, Dbsawy, M., additional, Deeb, A., additional, Hegazy, M., additional, Magdi, I., additional, Clarey, E., additional, Corcoran, E., additional, Finney, C., additional, Harris, C., additional, Hopkins, P., additional, Noble, H., additional, Thompson, L., additional, Williams, T., additional, Dumlao, L. A., additional, Bassam, R., additional, Hassan, M. A., additional, Naseem, N., additional, Al-Kurdi, M. H., additional, Al-Harthy, A. M., additional, Bernard, S., additional, Sebafundi, L., additional, Serban, C., additional, Lim, S. K., additional, Mazidah, N., additional, Saidin, N., additional, Sjamsuddin, N., additional, Tan, I. T. A., additional, Zabidi, N., additional, Brain, M., additional, Mineall, S., additional, Kanhere, M., additional, Soar, N., additional, Kadir, N. Abd, additional, Abdullah, N. H., additional, Awang, R., additional, Emperan, Z., additional, Husin, N. S., additional, Ismail, N. I., additional, Ismail, S. Z., additional, Khadzali, F. N. A. Mohd, additional, Norddin, M. F., additional, Aguila, J., additional, Bold, C., additional, Clatworthy, B., additional, Dias, A., additional, Hogan, C., additional, Kazemi, A., additional, Lai, V., additional, Song, R., additional, Williams, A., additional, Bhatia, D., additional, Elliot, S., additional, Galt, P., additional, Lavrans, K., additional, Ritchie, P., additional, Wang, A., additional, Gresham, R., additional, Lowrey, J., additional, Masters, K., additional, Palejs, P., additional, Seppelt, I., additional, Symonds, F., additional, Weisbrodt, L., additional, Whitehead, C., additional, Babio-Galan, M., additional, Calder, V., additional, Clement, I., additional, Harrison, A., additional, McCullagh, I., additional, Scott, C., additional, Bevan, R., additional, Caniba, S., additional, Hacking, D., additional, Maher, L., additional, Azzolini, M. L., additional, Beccaria, P., additional, Colombo, S., additional, Landoni, G., additional, Leggieri, C., additional, Luca, C., additional, Mamo, D., additional, Moizo, E., additional, Monti, G., additional, Mucci, M., additional, Zangrillo, A., additional, Albania, M., additional, Arora, S., additional, Shi, Y., additional, Abudayah, A., additional, Almekhlafi, G., additional, Al Amodi, E., additional, Al Samarrai, S., additional, Badawi, M., additional, Caba, R. Cubio, additional, Elffaki, O., additional, Mandourah, Y., additional, Valerio, J., additional, Joyce, C., additional, Meyer, J., additional, Saylor, E., additional, Venkatesh, B., additional, Venz, E., additional, Walsham, J., additional, Wetzig, K., additional, Khoo, T. M., additional, Liew, J. E. S., additional, Sakthi, A. N., additional, Zulkurnain, A., additional, Bamford, A., additional, Bergin, C., additional, Carrera, R., additional, Cooper, L., additional, Despy, L., additional, Harkett, S., additional, Mee, L., additional, Reeves, E., additional, Snelson, C., additional, Spruce, E., additional, Cooper, G., additional, Hodgson, R., additional, Pearson, D., additional, Rosbergen, M., additional, Ali, M. N., additional, Bahar, N. I., additional, Ismail, A., additional, Ismail, W. N. W., additional, Samat, N. M., additional, Piah, N. S. M., additional, Rahman, R. Abd, additional, Duroux, M., additional, Ratcliffe, M., additional, Warhurst, T., additional, Buehner, U., additional, Williams, E., additional, Jacques, N., additional, Keating, L., additional, Macgill, S., additional, Tamang, K. L., additional, Tolan, N., additional, Walden, A., additional, Bower, R., additional, Cranshaw, J., additional, Molloy, K., additional, Pitts, S., additional, Butler, J., additional, Dunlop, R., additional, Fourie, C., additional, Jarrett, P., additional, Lassig-Smith, M., additional, Livermore, A., additional, O’Donoghue, S., additional, Reade, M., additional, Starr, T., additional, Stuart, J., additional, Campbell, L., additional, Phillips, M., additional, Stephens, D., additional, Thomas, J., additional, Cooper, D., additional, McAllister, R., additional, Andrew, G., additional, Barclay, L., additional, Dawson, H., additional, Griffith, D. M., additional, Hope, D., additional, Wojcik, G., additional, McCulloch, C., additional, Paterson, R., additional, Ascough, L., additional, Paisley, C., additional, Patrick-Heselton, J., additional, Shaw, D., additional, Waugh, V., additional, Williams, K., additional, Welters, I., additional, Barge, D., additional, Jordan, A., additional, MacIsaac, C., additional, Rechnitzer, T., additional, Bass, F., additional, Gatward, J., additional, Hammond, N., additional, Janin, P., additional, Stedman, W., additional, Yarad, E., additional, Razak, N. A., additional, Dzulkipli, N., additional, Jong, S. L., additional, Asen, K., additional, Voon, W. L., additional, Liew, S., additional, Ball, J., additional, Barnes, V., additional, Dalton, C., additional, Farnell-Ward, S., additional, Farrah, H., additional, Maher, K., additional, Mellinghoff, J., additional, Ryan, C., additional, Shirley, P., additional, Conlon, L., additional, Glover, A., additional, Martin-Loeches, I., additional, O’Toole, E., additional, Ewan, J., additional, Ferrier, J., additional, Litton, E., additional, Webb, S. A., additional, Berry, W., additional, Blanco Alonso, U., additional, Bociek, A., additional, Campos, S., additional, Jawara, S., additional, Hanks, F., additional, Kelly, A., additional, Lei, K., additional, McKenzie, C., additional, Ostermann, M., additional, Wan, R., additional, Al-Soufi, S., additional, Leow, S., additional, McCann, K., additional, Reynolds, C., additional, Brickell, K., additional, Fahey, C., additional, Hays, L., additional, Hyde, N., additional, Nichol, A., additional, Ryan, D., additional, Brailsford, J., additional, Buckley, A., additional, Forbes, L., additional, Maguire, T., additional, Moore, J., additional, Murray, L., additional, Ghosh, A., additional, Park, M., additional, Said, S., additional, Visser, A., additional, Abidin, H. Z., additional, Ali, S., additional, Hassan, M. H., additional, Omar, S. C., additional, Shukeri, W. F. W., additional, Brealey, D., additional, Bercades, G., additional, Blackburn, E., additional, Macallum, N., additional, Macklin, A., additional, Ryu, J. H., additional, Tam, K., additional, Smyth, D., additional, Arif, A., additional, Bassford, C., additional, Morgan, C., additional, Swann, C., additional, Ward, G., additional, Wild, L., additional, Bone, A., additional, Elderkin, T., additional, Green, D., additional, Sach, D., additional, Salerno, T., additional, Simpson, N., additional, Brohi, F., additional, Clark, M., additional, Williams, L., additional, Brooks, J., additional, Cocks, E., additional, Cole, J., additional, Curtin, J., additional, Davies, R., additional, Hill, H., additional, Morgan, M., additional, Palmer, N., additional, Whitton, C., additional, Wise, M., additional, Baskaran, P., additional, Hasan, M. S., additional, Tham, L. Y., additional, Sol Cruz, R., additional, Dinsdale, D., additional, Edney, S., additional, Firkin, C., additional, FitzJohn, F., additional, Hill, G., additional, Hunt, A., additional, Hurford, S., additional, Jones, G., additional, Judd, H., additional, Latimer-Bell, C., additional, Lawrence, C., additional, Lesona, E., additional, Navarra, L., additional, Robertson, Y., additional, Smellie, H., additional, Vucago, A. M., additional, Young, P., additional, Clark, P., additional, Kong, J., additional, Ho, J., additional, Nayyar, V., additional, and Skelly, C., additional
- Published
- 2023
- Full Text
- View/download PDF
16. Where to Next in Combat Casualty Care Research?
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Pritchard, A. M., Higgs, A. R., Reade, M. C., and Vincent, Jean-Louis, editor
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- 2014
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- View/download PDF
17. Standardized Reporting, Registration, and a Multicenter, Multispecies Approach to Preclinical (Animal) Trials
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Reade, M. C., Kirkman, E., and Vincent, Jean-Louis, editor
- Published
- 2013
- Full Text
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18. A New Understanding of Coagulopathy in Trauma
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Reade, M. C., Holley, A. D., and Vincent, Jean-Louis, editor
- Published
- 2012
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19. The Impact of Chronic Disease on Response to Infection
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Reade, M. C., Milbrandt, E. B., Angus, D. C., and Vincent, Jean-Louis, editor
- Published
- 2007
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20. Comparison of two measures of behavior change in children after day surgery
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Cravero, J, Lee-Archer, PF, Gibbons, K, Reade, M, von Ungern-Sternberg, BS, Long, D, Cravero, J, Lee-Archer, PF, Gibbons, K, Reade, M, von Ungern-Sternberg, BS, and Long, D
- Abstract
BACKGROUND: A contemporary, well-validated instrument for the measurement of behavior change in children after general anesthesia is lacking. The Post Hospitalization Behavior Questionnaire for Ambulatory Surgery (PHBQ-AS) has been developed as an updated version of the original Post Hospitalization Behavior Questionnaire (PHBQ) to better reflect the current patient population and modern anesthetic practices. AIMS: To assess the reliability of the PHBQ-AS and determine concurrent validity with another measure of child behavior, the Strength and Difficulties Questionnaire (SDQ). METHODS: We compared the PHBQ-AS with the SDQ in 248 children presenting for day-case surgery. A baseline SDQ measurement was taken prior to surgery, and then, both scales were administered on days 3, 14, and 28 postsurgery. RESULTS: The PHBQ-AS demonstrated good reliability in terms of internal consistency with a Cronbach's alpha of 0.79 and split-half correlation with Spearman Brown adjustment of 0.85. There was weak correlation with the SDQ on day 3 postoperatively (Pearson's r = 0.201), moderate correlation on day 14 (Pearson's r = 0.421), and weak-to-moderate correlation on day 28 (Pearson's r = 0.340). A cut-off score of 3.2 on the PHBQ-AS for the diagnosis of negative behavior demonstrated equivalence with the SDQ results; however, the SDQ results remained relatively constant throughout the study period and reflected the expected rate of increased risk of problem behavior in children. CONCLUSIONS: The PHBQ-AS showed good reliability but only had weak-to-moderate correlation with another measure of child behavior, the SDQ. Further validation is required before the PHBQ-AS is used for the routine measurement of behavior change in children after anesthesia, or alternatively, a new instrument needs to be developed in order for research to advance in this area.
- Published
- 2022
21. A systematic review and meta-analysis of early goal-directed therapy for septic shock: the ARISE, ProCESS and ProMISe Investigators
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Angus, D. C., Barnato, A. E., Bell, D., Bellomo, R., Chong, C.-R., Coats, T. J., Davies, A., Delaney, A., Harrison, D. A., Holdgate, A., Howe, B., Huang, D. T., Iwashyna, T., Kellum, J. A., Peake, S. L., Pike, F., Reade, M. C., Rowan, K. M., Singer, M., Webb, S. A. R., Weissfeld, L. A., Yealy, D. M., and Young, J. D.
- Published
- 2015
- Full Text
- View/download PDF
22. Efficacy and safety of fibrinogen concentrate in trauma patients—a systematic review☆,☆☆,★
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Aubron, C., Reade, M. C., Fraser, J. F., and Cooper, D. J.
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- 2014
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- View/download PDF
23. On a Subclass of Bazilevič Functions
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Eenigenburg, P. J., Miller, S. S., Mocanu, P. T., and Reade, M. O.
- Published
- 1974
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- View/download PDF
24. Intracranial pressure monitoring in patients with acute brain injury in the intensive care unit (SYNAPSE-ICU): an international, prospective observational cohort study
- Author
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Robba, Chiara, primary, Graziano, Francesca, additional, Rebora, Paola, additional, Elli, Francesca, additional, Giussani, Carlo, additional, Oddo, Mauro, additional, Meyfroidt, Geert, additional, Helbok, Raimund, additional, Taccone, Fabio S, additional, Prisco, Lara, additional, Vincent, Jean-Louis, additional, Suarez, Jose I, additional, Stocchetti, Nino, additional, Citerio, Giuseppe, additional, Abdelaty, M., additional, Abed Maillard, S., additional, Ahmed, H., additional, Albrecht, L., additional, Alsudani, A., additional, Amundarain, E.D., additional, Anand, S., additional, Andersen, J.B., additional, Anglada, M., additional, Arabi, Y, additional, Aragao, I., additional, Arias Verdu, M.D., additional, Asehnoune, K., additional, Assunção, F., additional, Audibert, G., additional, Badenes, R., additional, Bajracharya, T., additional, Banco, P., additional, Batista, D., additional, Bertellini, E., additional, Berty Gutiérrez, H., additional, Besch, G., additional, Biston, P., additional, Blandino Ortiz, A., additional, Blazquez, V., additional, Bloria, S., additional, Bonetti, C., additional, Bresil, P., additional, Brunetti, I., additional, Buldini, V., additional, Caillard, A., additional, Calamai, I., additional, Carbonara, M., additional, Caricato, A., additional, Casadio, M.C., additional, Casanova, M., additional, Cavaleiro, P., additional, Celaya Lopez, M., additional, Chan, C.Y., additional, Chauhan, R., additional, Cinotti, R., additional, Corral, L., additional, Cortegiani, A., additional, Cotoia, A., additional, Crippa, I.A., additional, Davidovich, V., additional, Del Bianco, S., additional, Diakaki, C., additional, Dibu, J., additional, Dimoula, A., additional, Domeniconi, G., additional, Dominguez, L.J.Y., additional, Dovbysh, N., additional, Duque, P., additional, Eddelien, H.S., additional, Efthymiou, A., additional, Egmose Larsen, T., additional, Elhadi, M., additional, Favre Eva, E., additional, Fencl, M., additional, Forjan, P., additional, Freitas, R., additional, Fuest, K., additional, Fumale, M., additional, Gakuba, C., additional, Galarza, L., additional, García, M.F., additional, Gasca López, G.A., additional, Gelormini, C., additional, Gempeler, A., additional, Giannopoulos, A., additional, Giménez, M.E., additional, Giugni, A., additional, Glorieux, D., additional, Gonzalez Perez, M.I., additional, Gradisek, P., additional, Grandis, M., additional, Griesdale, D., additional, Gritsan, A., additional, Grotheer, S., additional, Gupta, D., additional, Hallt, E.D., additional, Hawthorne, C., additional, Helbok, R., additional, Holm, M.O., additional, Iasonidou, C., additional, Idowu, O., additional, Ioannoni, E., additional, Izzi, A., additional, Jibaja, M., additional, Kafle, P., additional, Kandamby, D.H., additional, Khan, M.M., additional, Khomiakov, S., additional, Kilapong, B., additional, Kletecka, J., additional, Kojder, K., additional, Kolias, A., additional, Kontoudaki, E., additional, Koukoulitsios, G., additional, Kovac, N., additional, Kozar, S., additional, Krieg, S.M., additional, Kurtz, P., additional, Kyriazopoulos, G., additional, Lamperti, M., additional, Lavicka, P., additional, Lencastre, L., additional, Levin, M., additional, Lightfoot, R., additional, Lindner, A., additional, López Ojeda, P., additional, Lores, A., additional, Lucca, M., additional, Luthra, A., additional, Magni, F., additional, Majholm, B., additional, Makris, D., additional, Maldonado, F., additional, Marudi, A., additional, Maskey, S., additional, Mebis, L., additional, Mejia-Mantilla, J.H., additional, Mendoza, R., additional, Milivojevic, N., additional, Miroz, J.P., additional, Monleon, B., additional, Montes, J.M., additional, Morelli, P., additional, Motta, A., additional, Mouloudi, E., additional, Muehlschlegel, S., additional, Ñamendys Silva, S.A., additional, Nardai, G., additional, Nilam, K., additional, Olson, D., additional, Ozair, A., additional, Pacheco, C., additional, Padilla Juan, J., additional, Palli, E., additional, Panda, N., additional, Pantelas, N., additional, Pariente, L., additional, Pearson, D., additional, Pérez-Araos, R., additional, Picetti, E., additional, Pinedo Portilla, J.L., additional, Pons, B., additional, Pozzi, F., additional, Provaznikova, E., additional, Quartarone, M.C., additional, Quintard, H., additional, Rajbanshi, L., additional, Reade, M., additional, Ribaric, S.F., additional, Rigamonti, A., additional, Rivera, L.L., additional, Roberts, J., additional, Roka, Y.B., additional, Sabelnikovs, O., additional, Sapra, H., additional, Schaller, S.J., additional, Sekhon, M., additional, Sellami, W., additional, Seppelt, I., additional, Serrano, A., additional, Sharma, K., additional, Shrestha, G.S., additional, Shum, H.P., additional, Silva, S., additional, Simoes, M., additional, Sivakumar, S., additional, Siviter, R., additional, Skola, J., additional, Škoti, M., additional, Smitt, M., additional, Soley, R., additional, Sonneville, R., additional, Soragni, A., additional, Soyer, B., additional, Spatenkova, V., additional, Stamou, E.E., additional, Stival, E., additional, Olson, Z., additional, Tánczos, K., additional, Thompson, C., additional, Thomsen, J., additional, Tsikriki, S., additional, Van De Velde, S., additional, Videtta, W., additional, Villa, F., additional, Vrbica, K., additional, Vrettou, C., additional, Westy Hoffmeyer, H., additional, Wolf, S., additional, Yasin Wayhs, S., additional, and Zerbi, S.M., additional
- Published
- 2021
- Full Text
- View/download PDF
25. Early sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial.
- Author
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Abidin H.Z., Hassan M.H., Omar S.C., Shukeri W.F.W., Brealey D., Bercades G., Blackburn E., Macallum N., Macklin A., Ryu J.H., Tam K., Smyth D., Arif A., Bassford C., Morgan C., Swann C., Ward G., Wild L., Bone A., Elderkin T., Green D., Sach D., Salerno T., Simpson N., Brohi F., Clark M., Williams L., Brooks J., Cocks E., Cole J., Curtin J., Davies R., Hill H., Morgan M., Palmer N., Whitton C., Wise M., Baskaran P., Hasan M.S., Tham L.Y., Cruz R.S., Dinsdale D., Edney S., Firkin C., FitzJohn F., Hill G., Hunt A., Hurford S., Jones G., Judd H., Latimer-Bell C., Lawrence C., Lesona E., Navarra L., Robertson Y., Smellie H., Vucago A.M., Young P., Dawson H., Griffith D.M., Paterson R., Clark P., Kong J., Ho J., Nayyar V., Skelly C., Shehabi Y., Serpa Neto A., Howe B.D., Arabi Y.M., Bass F.E., Kadiman S.B., McArthur C.J., Reade M.C., Seppelt I.M., Wise M.P., Mashonganyika C., McKee H., Tonks A., Donnelly A., Hemmings N., O'Kane S., Blakemore A., Butler M., Cowdrey K., Dalton J., Gilder E., Long S., McCarthy L., McGuinness S., Parke R., Chen Y., McArthur C., McConnochie R., Newby L., Bellomo R., Eastwood G., Peck L., Young H., Boschert C., Edington J., Fletcher J., Nand K., Raza A., Sara T., Bennett-Britton J., Bewley J., Bodenham V., Cole L., Driver K., Grimmer L., Howie L., Searles C., Sweet K., Webster D., van Berkel A., Connor H., Dennett J., van Der Graaff M., Henderson S., Mehrtens J., Miller K., Minto E., Morris A., Noble S., Parker K., Hart N., Shepherd K., Vij S., Dickson S., Elloway E., Ferguson C., Jackson R., MacNaughton P., Marner M., Squire R., Waddy S., Wafer P., Welbourne J., Ashcroft P., Chambler D., Dukes S., Harris A., Horton S., Sharpe S., Williams P., Williams S., Bailey M., Blazquez E., France D., Hutchison R., Comadira G., Gough M., Tallott M., Bastick M., Cameron R., Donovan S., Gaur A., Gregory R., Naumoff J., Turner E., White M., Au K.F.J., Fratzia J., Treloar S., Lim C.H., Maseeda Y., Tan A.P., Tang C.L., Yong C.Y., Akaltan M., Berger S., Blaser D., Fazlija L., Jong M.L., Lensch M., Ludwig R., Merz T., Nettelbeck K., Roth M., Schafer M., Takala J., Wehr A., Zacharias D., Amran R., Ashraf H.N., Azmi N., Basri N., Burhanuddin H., Hadinata Y., Hamdan A., Kadiman S., Rashid A.I.Y.M., Sabran I.N., Sulaiman S., Zabidi I.N., Al-Dawood A., Aljuaid M., Al Anizi H., Al Saeedi A., Arabi Y., Dbsawy M., Deeb A., Hegazy M., Magdi I., Corcoran E., Finney C., Dumlao L.A., Bassam R., Hassan M.A., Naseem N., Al-Kurdi M.H., Al-Harthy A.M., Bernard S., Sebafundi L., Serban C., Lim S.K., Mazidah N., Saidin N., Sjamsuddin N., Tan I.T.A., Zabidi N., Brain M., Mineall S., Kanhere M., Soar N., Kadir N.A., Abdullah N.H., Awang R., Emperan Z., Husin N.S., Ismail N.I., Ismail S.Z., Khadzali F.N.A.M., Norddin M.F., Aguila J., Bold C., Clatworthy B., Dias A., Hogan C., Kazemi A., Lai V., Song R., Williams A., Bhatia D., Bulfin L., Elliot S., Galt P., Lavrans K., Ritchie P., Wang A., Gresham R., Lowrey J., Masters K., Palejs P., Seppelt I., Symonds F., Weisbrodt L., Whitehead C., Babio-Galan M., Calder V., Clement I., Harrison A., McCullagh I., Scott C., Bevan R., Caniba S., Hacking D., Maher L., Azzolini M.L., Beccaria P., Colombo S., Landoni G., Leggieri C., Luca C., Mamo D., Moizo E., Monti G., Mucci M., Zangrillo A., Albania M., Arora S., Shi Y., Abudayah A., Almekhlafi G., Al Amodi E., Al Samarrai S., Badawi M., Caba R.C., Elffaki O., Mandourah Y., Valerio J., Joyce C., Meyer J., Saylor E., Venkatesh B., Venz E., Walsham J., Wetzig K., Clarey E., Harris C., Hopkins P., Noble H., Thompson L., Williams T., Khoo T.M., Liew J.E.S., Sakthi A.N., Zulkurnain A., Bamford A., Bergin C., Carrera R., Cooper L., Despy L., Ellis K., Harkett S., Mee L., Reeves E., Snelson C., Spruce E., Cooper G., Hodgson R., Pearson D., Rosbergen M., Ali M.N., Bahar N.I., Ismail A., Ismail W.N.W., Samat N.M., Piah N.S.M., Rahman R.A., Duroux M., Ratcliffe M., Warhurst T., Buehner U., Williams E., Jacques N., Keating L., Macgill S., Tamang K.L., Tolan N., Walden A., Bower R., Cranshaw J., Molloy K., Pitts S., Butler J., Dunlop R., Fourie C., Jarrett P., Lassig-Smith M., Livermore A., O'Donoghue S., Reade M., Starr T., Stuart J., Campbell L., Phillips M., Stephens D., Thomas J., Cooper D., McAllister R., Andrew G., Barclay L., Hope D., Wojcik G., McCulloch C., Ascough L., Paisley C., Patrick-Heselton J., Shaw D., Waugh V., Williams K., Welters I., Barge D., Jordan A., MacIsaac C., Rechnitzer T., Bass F., Gatward J., Hammond N., Janin P., O'Connor A., Stedman W., Yarad E., Razak N.A., Dzulkipli N., Jong S.L., Asen K., Voon W.L., Liew S., Ball J., Barnes V., Dalton C., Farnell-Ward S., Farrah H., Maher K., Mellinghoff J., Ryan C., Shirley P., Conlon L., Glover A., Martin-Loeches I., O'Toole E., Ewan J., Ferrier J., Litton E., Webb S.A., Berry W., Alonso U.B., Bociek A., Campos S., Jawara S., Hanks F., Kelly A., Lei K., McKenzie C., Ostermann M., Wan R., Al-Soufi S., Leow S., McCann K., Reynolds C., Brickell K., Fahey C., Hays L., Hyde N., Nichol A., Ryan D., Brailsford J., Buckley A., Forbes L., Maguire T., Moore J., Murray L., Ghosh A., Park M., Said S., Smith J., Visser A., Ali S., Abidin H.Z., Hassan M.H., Omar S.C., Shukeri W.F.W., Brealey D., Bercades G., Blackburn E., Macallum N., Macklin A., Ryu J.H., Tam K., Smyth D., Arif A., Bassford C., Morgan C., Swann C., Ward G., Wild L., Bone A., Elderkin T., Green D., Sach D., Salerno T., Simpson N., Brohi F., Clark M., Williams L., Brooks J., Cocks E., Cole J., Curtin J., Davies R., Hill H., Morgan M., Palmer N., Whitton C., Wise M., Baskaran P., Hasan M.S., Tham L.Y., Cruz R.S., Dinsdale D., Edney S., Firkin C., FitzJohn F., Hill G., Hunt A., Hurford S., Jones G., Judd H., Latimer-Bell C., Lawrence C., Lesona E., Navarra L., Robertson Y., Smellie H., Vucago A.M., Young P., Dawson H., Griffith D.M., Paterson R., Clark P., Kong J., Ho J., Nayyar V., Skelly C., Shehabi Y., Serpa Neto A., Howe B.D., Arabi Y.M., Bass F.E., Kadiman S.B., McArthur C.J., Reade M.C., Seppelt I.M., Wise M.P., Mashonganyika C., McKee H., Tonks A., Donnelly A., Hemmings N., O'Kane S., Blakemore A., Butler M., Cowdrey K., Dalton J., Gilder E., Long S., McCarthy L., McGuinness S., Parke R., Chen Y., McArthur C., McConnochie R., Newby L., Bellomo R., Eastwood G., Peck L., Young H., Boschert C., Edington J., Fletcher J., Nand K., Raza A., Sara T., Bennett-Britton J., Bewley J., Bodenham V., Cole L., Driver K., Grimmer L., Howie L., Searles C., Sweet K., Webster D., van Berkel A., Connor H., Dennett J., van Der Graaff M., Henderson S., Mehrtens J., Miller K., Minto E., Morris A., Noble S., Parker K., Hart N., Shepherd K., Vij S., Dickson S., Elloway E., Ferguson C., Jackson R., MacNaughton P., Marner M., Squire R., Waddy S., Wafer P., Welbourne J., Ashcroft P., Chambler D., Dukes S., Harris A., Horton S., Sharpe S., Williams P., Williams S., Bailey M., Blazquez E., France D., Hutchison R., Comadira G., Gough M., Tallott M., Bastick M., Cameron R., Donovan S., Gaur A., Gregory R., Naumoff J., Turner E., White M., Au K.F.J., Fratzia J., Treloar S., Lim C.H., Maseeda Y., Tan A.P., Tang C.L., Yong C.Y., Akaltan M., Berger S., Blaser D., Fazlija L., Jong M.L., Lensch M., Ludwig R., Merz T., Nettelbeck K., Roth M., Schafer M., Takala J., Wehr A., Zacharias D., Amran R., Ashraf H.N., Azmi N., Basri N., Burhanuddin H., Hadinata Y., Hamdan A., Kadiman S., Rashid A.I.Y.M., Sabran I.N., Sulaiman S., Zabidi I.N., Al-Dawood A., Aljuaid M., Al Anizi H., Al Saeedi A., Arabi Y., Dbsawy M., Deeb A., Hegazy M., Magdi I., Corcoran E., Finney C., Dumlao L.A., Bassam R., Hassan M.A., Naseem N., Al-Kurdi M.H., Al-Harthy A.M., Bernard S., Sebafundi L., Serban C., Lim S.K., Mazidah N., Saidin N., Sjamsuddin N., Tan I.T.A., Zabidi N., Brain M., Mineall S., Kanhere M., Soar N., Kadir N.A., Abdullah N.H., Awang R., Emperan Z., Husin N.S., Ismail N.I., Ismail S.Z., Khadzali F.N.A.M., Norddin M.F., Aguila J., Bold C., Clatworthy B., Dias A., Hogan C., Kazemi A., Lai V., Song R., Williams A., Bhatia D., Bulfin L., Elliot S., Galt P., Lavrans K., Ritchie P., Wang A., Gresham R., Lowrey J., Masters K., Palejs P., Seppelt I., Symonds F., Weisbrodt L., Whitehead C., Babio-Galan M., Calder V., Clement I., Harrison A., McCullagh I., Scott C., Bevan R., Caniba S., Hacking D., Maher L., Azzolini M.L., Beccaria P., Colombo S., Landoni G., Leggieri C., Luca C., Mamo D., Moizo E., Monti G., Mucci M., Zangrillo A., Albania M., Arora S., Shi Y., Abudayah A., Almekhlafi G., Al Amodi E., Al Samarrai S., Badawi M., Caba R.C., Elffaki O., Mandourah Y., Valerio J., Joyce C., Meyer J., Saylor E., Venkatesh B., Venz E., Walsham J., Wetzig K., Clarey E., Harris C., Hopkins P., Noble H., Thompson L., Williams T., Khoo T.M., Liew J.E.S., Sakthi A.N., Zulkurnain A., Bamford A., Bergin C., Carrera R., Cooper L., Despy L., Ellis K., Harkett S., Mee L., Reeves E., Snelson C., Spruce E., Cooper G., Hodgson R., Pearson D., Rosbergen M., Ali M.N., Bahar N.I., Ismail A., Ismail W.N.W., Samat N.M., Piah N.S.M., Rahman R.A., Duroux M., Ratcliffe M., Warhurst T., Buehner U., Williams E., Jacques N., Keating L., Macgill S., Tamang K.L., Tolan N., Walden A., Bower R., Cranshaw J., Molloy K., Pitts S., Butler J., Dunlop R., Fourie C., Jarrett P., Lassig-Smith M., Livermore A., O'Donoghue S., Reade M., Starr T., Stuart J., Campbell L., Phillips M., Stephens D., Thomas J., Cooper D., McAllister R., Andrew G., Barclay L., Hope D., Wojcik G., McCulloch C., Ascough L., Paisley C., Patrick-Heselton J., Shaw D., Waugh V., Williams K., Welters I., Barge D., Jordan A., MacIsaac C., Rechnitzer T., Bass F., Gatward J., Hammond N., Janin P., O'Connor A., Stedman W., Yarad E., Razak N.A., Dzulkipli N., Jong S.L., Asen K., Voon W.L., Liew S., Ball J., Barnes V., Dalton C., Farnell-Ward S., Farrah H., Maher K., Mellinghoff J., Ryan C., Shirley P., Conlon L., Glover A., Martin-Loeches I., O'Toole E., Ewan J., Ferrier J., Litton E., Webb S.A., Berry W., Alonso U.B., Bociek A., Campos S., Jawara S., Hanks F., Kelly A., Lei K., McKenzie C., Ostermann M., Wan R., Al-Soufi S., Leow S., McCann K., Reynolds C., Brickell K., Fahey C., Hays L., Hyde N., Nichol A., Ryan D., Brailsford J., Buckley A., Forbes L., Maguire T., Moore J., Murray L., Ghosh A., Park M., Said S., Smith J., Visser A., and Ali S.
- Abstract
Purpose: To quantify potential heterogeneity of treatment effect (HTE), of early sedation with dexmedetomidine (DEX) compared with usual care, and identify patients who have a high probability of lower or higher 90-day mortality according to age, and other identified clusters. Method(s): Bayesian analysis of 3904 critically ill adult patients expected to receive invasive ventilation > 24 h and enrolled in a multinational randomized controlled trial comparing early DEX with usual care sedation. Result(s): HTE was assessed according to age and clusters (based on 12 baseline characteristics) using a Bayesian hierarchical models. DEX was associated with lower 90-day mortality compared to usual care in patients > 65 years (odds ratio [OR], 0.83 [95% credible interval [CrI] 0.68-1.00], with 97.7% probability of reduced mortality across broad categories of illness severity. Conversely, the probability of increased mortality in patients = 65 years was 98.5% (OR 1.26 [95% CrI 1.02-1.56]. Two clusters were identified: cluster 1 (976 patients) mostly operative, and cluster 2 (2346 patients), predominantly non-operative. There was a greater probability of benefit with DEX in cluster 1 (OR 0.86 [95% CrI 0.65-1.14]) across broad categories of age, with 86.4% probability that DEX is more beneficial in cluster 1 than cluster 2. Conclusion(s): In critically ill mechanically ventilated patients, early sedation with dexmedetomidine exhibited a high probability of reduced 90-day mortality in older patients regardless of operative or non-operative cluster status. Conversely, a high probability of increased 90-day mortality was observed in younger patients of non-operative status. Further studies are needed to confirm these findings.Copyright © 2021, Crown.
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- 2021
26. Aussie KIDS SAVE LIVES: A position statement from the Australian Resuscitation Council and supported by stakeholders
- Author
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Bray, J, Acworth, J, Page, G, Parr, M, Morley, P, Cameron, A, Carey, C, Celenza, A, Christiansen, R, Considine, Julie, Douglas, N, Dunbabin, T, Eastwood, K, Finn, J, Flemming-Judge, E, Gale, M, Grantham, H, Kidd, T, Leman, P, Liley, H, Macneil, F, Morrison, A, Murphy, M, Nation, K, Nicholson, M, Pearn, J, Ray, C, Reade, M, Scarff, C, Scott, T, Smith, T, Stub, D, Sunderasan, L, Thio, M, Bray, J, Acworth, J, Page, G, Parr, M, Morley, P, Cameron, A, Carey, C, Celenza, A, Christiansen, R, Considine, Julie, Douglas, N, Dunbabin, T, Eastwood, K, Finn, J, Flemming-Judge, E, Gale, M, Grantham, H, Kidd, T, Leman, P, Liley, H, Macneil, F, Morrison, A, Murphy, M, Nation, K, Nicholson, M, Pearn, J, Ray, C, Reade, M, Scarff, C, Scott, T, Smith, T, Stub, D, Sunderasan, L, and Thio, M
- Abstract
Every year 25 000 Australians experience a cardiac arrest in our community, but only 12% survive. The faster cardiopulmonary resuscitation and defibrillation, known as basic life support (BLS), is commenced, the greater the chance of survival. Currently, only half of the Australian adults are trained in BLS. The Australian Resuscitation Council and key stakeholder organisations believe that the best way to ensure all Australians know how to save a life is by mandating BLS education and training in our schools. This ‘Aussie KIDS SAVE LIVES’ position statement outlines our strategy to help facilitate the introduction of a programme of regular BLS training into the Australian school curriculum.
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- 2021
27. The effect of dexmedetomidine on postoperative behaviour change in children: a randomised controlled trial (vol 75, pg 1461, 2020)
- Author
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Lee-Archer, PF, von Ungern-Sternberg, BS, Reade, M, Lee-Archer, PF, von Ungern-Sternberg, BS, and Reade, M
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- 2021
28. Intracranial pressure monitoring in patients with acute brain injury in the intensive care unit (SYNAPSE-ICU): an international, prospective observational cohort study
- Author
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Robba, C., Graziano, F., Rebora, P., Elli, F., Giussani, C., Oddo, M., Meyfroidt, G., Helbok, R., Taccone, F. S., Prisco, L., Vincent, J. -L., Suarez, J. I., Stocchetti, N., Citerio, G., Abdelaty, M., Abed Maillard, S., Ahmed, H., Albrecht, L., Alsudani, A., Amundarain, E. D., Anand, S., Andersen, J. B., Anglada, M., Arabi, Y., Aragao, I., Arias Verdu, M. D., Asehnoune, K., Assuncao, F., Audibert, G., Badenes, R., Bajracharya, T., Banco, P., Batista, D., Bertellini, E., Berty Gutierrez, H., Besch, G., Biston, P., Blandino Ortiz, A., Blazquez, V., Bloria, S., Bonetti, C., Bresil, P., Brunetti, I., Buldini, V., Caillard, A., Calamai, I., Carbonara, M., Caricato, Anselmo, Casadio, M. C., Casanova, M., Cavaleiro, P., Celaya Lopez, M., Chan, C. Y., Chauhan, R., Cinotti, R., Corral, L., Cortegiani, A., Cotoia, A., Crippa, I. A., Davidovich, V., Del Bianco, S., Diakaki, C., Dibu, J., Dimoula, A., Domeniconi, G., Dominguez, L. J. Y., Dovbysh, N., Duque, P., Eddelien, H. S., Efthymiou, A., Egmose Larsen, T., Elhadi, M., Favre Eva, E., Fencl, M., Forjan, P., Freitas, R., Fuest, K., Fumale, M., Gakuba, C., Galarza, L., Garcia, M. F., Gasca Lopez, G. A., Gelormini, C., Gempeler, A., Giannopoulos, A., Gimenez, M. E., Giugni, A., Glorieux, D., Gonzalez Perez, M. I., Gradisek, P., Grandis, M., Griesdale, D., Gritsan, A., Grotheer, S., Gupta, D., Hallt, E. D., Hawthorne, C., Holm, M. O., Iasonidou, C., Idowu, O., Ioannoni, E., Izzi, A., Jibaja, M., Kafle, P., Kandamby, D. H., Khan, M. M., Khomiakov, S., Kilapong, B., Kletecka, J., Kojder, K., Kolias, A., Kontoudaki, E., Koukoulitsios, G., Kovac, N., Kozar, S., Krieg, S. M., Kurtz, P., Kyriazopoulos, G., Lamperti, M., Lavicka, P., Lencastre, L., Levin, M., Lightfoot, R., Lindner, A., Lopez Ojeda, P., Lores, A., Lucca, M., Luthra, A., Magni, F., Majholm, B., Makris, D., Maldonado, F., Marudi, A., Maskey, S., Mebis, L., Mejia-Mantilla, J. H., Mendoza, R., Milivojevic, N., Miroz, J. P., Monleon, B., Montes, J. M., Morelli, P., Motta, A., Mouloudi, E., Muehlschlegel, S., Namendys Silva, S. A., Nardai, G., Nilam, K., Olson, D., Ozair, A., Pacheco, C., Padilla Juan, J., Palli, E., Panda, N., Pantelas, N., Pariente, L., Pearson, D., Perez-Araos, R., Picetti, E., Pinedo Portilla, J. L., Pons, B., Pozzi, F., Provaznikova, E., Quartarone, M. C., Quintard, H., Rajbanshi, L., Reade, M., Ribaric, S. F., Rigamonti, A., Rivera, L. L., Roberts, J., Roka, Y. B., Sabelnikovs, O., Sapra, H., Schaller, S. J., Sekhon, M., Sellami, W., Seppelt, I., Serrano, A., Sharma, K., Shrestha, G. S., Shum, H. P., Silva, S., Simoes, M., Sivakumar, S., Siviter, R., Skola, J., Skoti, M., Smitt, M., Soley, R., Sonneville, R., Soragni, A., Soyer, B., Spatenkova, V., Stamou, E. E., Stival, Eleonora, Olson, Z., Tanczos, K., Thompson, C., Thomsen, J., Tsikriki, S., Van De Velde, S., Videtta, W., Villa, F., Vrbica, K., Vrettou, C., Westy Hoffmeyer, H., Wolf, S., Yasin Wayhs, S., Zerbi, S. M., Caricato A. (ORCID:0000-0001-5929-120X), Stival E., Robba, C., Graziano, F., Rebora, P., Elli, F., Giussani, C., Oddo, M., Meyfroidt, G., Helbok, R., Taccone, F. S., Prisco, L., Vincent, J. -L., Suarez, J. I., Stocchetti, N., Citerio, G., Abdelaty, M., Abed Maillard, S., Ahmed, H., Albrecht, L., Alsudani, A., Amundarain, E. D., Anand, S., Andersen, J. B., Anglada, M., Arabi, Y., Aragao, I., Arias Verdu, M. D., Asehnoune, K., Assuncao, F., Audibert, G., Badenes, R., Bajracharya, T., Banco, P., Batista, D., Bertellini, E., Berty Gutierrez, H., Besch, G., Biston, P., Blandino Ortiz, A., Blazquez, V., Bloria, S., Bonetti, C., Bresil, P., Brunetti, I., Buldini, V., Caillard, A., Calamai, I., Carbonara, M., Caricato, Anselmo, Casadio, M. C., Casanova, M., Cavaleiro, P., Celaya Lopez, M., Chan, C. Y., Chauhan, R., Cinotti, R., Corral, L., Cortegiani, A., Cotoia, A., Crippa, I. A., Davidovich, V., Del Bianco, S., Diakaki, C., Dibu, J., Dimoula, A., Domeniconi, G., Dominguez, L. J. Y., Dovbysh, N., Duque, P., Eddelien, H. S., Efthymiou, A., Egmose Larsen, T., Elhadi, M., Favre Eva, E., Fencl, M., Forjan, P., Freitas, R., Fuest, K., Fumale, M., Gakuba, C., Galarza, L., Garcia, M. F., Gasca Lopez, G. A., Gelormini, C., Gempeler, A., Giannopoulos, A., Gimenez, M. E., Giugni, A., Glorieux, D., Gonzalez Perez, M. I., Gradisek, P., Grandis, M., Griesdale, D., Gritsan, A., Grotheer, S., Gupta, D., Hallt, E. D., Hawthorne, C., Holm, M. O., Iasonidou, C., Idowu, O., Ioannoni, E., Izzi, A., Jibaja, M., Kafle, P., Kandamby, D. H., Khan, M. M., Khomiakov, S., Kilapong, B., Kletecka, J., Kojder, K., Kolias, A., Kontoudaki, E., Koukoulitsios, G., Kovac, N., Kozar, S., Krieg, S. M., Kurtz, P., Kyriazopoulos, G., Lamperti, M., Lavicka, P., Lencastre, L., Levin, M., Lightfoot, R., Lindner, A., Lopez Ojeda, P., Lores, A., Lucca, M., Luthra, A., Magni, F., Majholm, B., Makris, D., Maldonado, F., Marudi, A., Maskey, S., Mebis, L., Mejia-Mantilla, J. H., Mendoza, R., Milivojevic, N., Miroz, J. P., Monleon, B., Montes, J. M., Morelli, P., Motta, A., Mouloudi, E., Muehlschlegel, S., Namendys Silva, S. A., Nardai, G., Nilam, K., Olson, D., Ozair, A., Pacheco, C., Padilla Juan, J., Palli, E., Panda, N., Pantelas, N., Pariente, L., Pearson, D., Perez-Araos, R., Picetti, E., Pinedo Portilla, J. L., Pons, B., Pozzi, F., Provaznikova, E., Quartarone, M. C., Quintard, H., Rajbanshi, L., Reade, M., Ribaric, S. F., Rigamonti, A., Rivera, L. L., Roberts, J., Roka, Y. B., Sabelnikovs, O., Sapra, H., Schaller, S. J., Sekhon, M., Sellami, W., Seppelt, I., Serrano, A., Sharma, K., Shrestha, G. S., Shum, H. P., Silva, S., Simoes, M., Sivakumar, S., Siviter, R., Skola, J., Skoti, M., Smitt, M., Soley, R., Sonneville, R., Soragni, A., Soyer, B., Spatenkova, V., Stamou, E. E., Stival, Eleonora, Olson, Z., Tanczos, K., Thompson, C., Thomsen, J., Tsikriki, S., Van De Velde, S., Videtta, W., Villa, F., Vrbica, K., Vrettou, C., Westy Hoffmeyer, H., Wolf, S., Yasin Wayhs, S., Zerbi, S. M., Caricato A. (ORCID:0000-0001-5929-120X), and Stival E.
- Abstract
Background: The indications for intracranial pressure (ICP) monitoring in patients with acute brain injury and the effects of ICP on patients’ outcomes are uncertain. The aims of this study were to describe current ICP monitoring practises for patients with acute brain injury at centres around the world and to assess variations in indications for ICP monitoring and interventions, and their association with long-term patient outcomes. Methods: We did a prospective, observational cohort study at 146 intensive care units (ICUs) in 42 countries. We assessed for eligibility all patients aged 18 years or older who were admitted to the ICU with either acute brain injury due to primary haemorrhagic stroke (including intracranial haemorrhage or subarachnoid haemorrhage) or traumatic brain injury. We included patients with altered levels of consciousness at ICU admission or within the first 48 h after the brain injury, as defined by the Glasgow Coma Scale (GCS) eye response score of 1 (no eye opening) and a GCS motor response score of at least 5 (not obeying commands). Patients not admitted to the ICU or with other forms of acute brain injury were excluded from the study. Between-centre differences in use of ICP monitoring were quantified by using the median odds ratio (MOR). We used the therapy intensity level (TIL) to quantify practice variations in ICP interventions. Primary endpoints were 6 month mortality and 6 month Glasgow Outcome Scale Extended (GOSE) score. A propensity score method with inverse probability of treatment weighting was used to estimate the association between use of ICP monitoring and these 6 month outcomes, independently of measured baseline covariates. This study is registered with ClinicalTrial.gov, NCT03257904. Findings: Between March 15, 2018, and April 30, 2019, 4776 patients were assessed for eligibility and 2395 patients were included in the study, including 1287 (54%) with traumatic brain injury, 587 (25%) with intracranial haemorrhage, and 52
- Published
- 2021
29. Experiences of medical practitioners in the Australian Defence Force on live tissue trauma training
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Mahoney, Adam, Reade, M C, and Moffat, M
- Abstract
IntroductionCare of battle casualties is a central role of military medical practitioners. Historically, certain trauma procedural skills have been learnt through live tissue training. However, faced with opposition from community members and academics, who argue equivalence of non-animal alternatives, this is now being phased out. This study explores Australian military medical practitioners’ experiences of and attitudes towards live tissue training.MethodWe performed a phenomenologically driven qualitative exploration of individuals’ experiences of live tissue trauma training. 32 medical officers volunteered for the study. In-depth interviews were conducted with 15 practitioners (60% Army, 20% Air Force, 20% Navy; 33% surgical, 53% critical care, 13% general practice). Qualitative data were subjected to content analysis, with key themes identified using manual and computer-assisted coding.ResultsLive tissue training was valued by military medical practitioners, particularly because of the realistic feel of tissues and physiological responsiveness to treatment. Learner-perceived value of live tissue training was higher for complex skills and those requiring delicate tissue handling. 100% of surgeons and critical care doctors regarded live tissue as the only suitable model for learning repair of penetrating cardiac injury. Live tissue training was felt to enhance self-efficacy, particularly for rarely applied skills. Though conscious of the social and ethical context of live tissue training, >90% of participants reported positive emotional responses to live tissue training.ConclusionIn contrast to published research, live tissue training was thought by participants to possess characteristics that are not yet replicable using alternative learning aids. The experienced positive values of live tissue training should inform the decision to move towards non-animal alternatives.
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- 2023
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30. The effect of dexmedetomidine on vasopressor requirements in patients with septic shock: A subgroup analysis of the Sedation Practice in Intensive Care Evaluation [SPICE III] Trial.
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Webb S.A., Cioccari L., Luethi N., Bailey M., Messmer A.S., Proimos H.K., Peck L., Young H., Eastwood G.M., Merz T.M., Jakob S.M., Arabi Y., Erickson S., Shehabi Y., Howe B., Bellomo R., Arabi Y.M., Bass F., Kadiman S., McArthur C., Reade M., Seppelt I., Takala J., Wise M.P., Bailey M.J., Howe B.D., Murray L., Singh V., Webb S.A., Cioccari L., Luethi N., Bailey M., Messmer A.S., Proimos H.K., Peck L., Young H., Eastwood G.M., Merz T.M., Jakob S.M., Arabi Y., Erickson S., Shehabi Y., Howe B., Bellomo R., Arabi Y.M., Bass F., Kadiman S., McArthur C., Reade M., Seppelt I., Takala J., Wise M.P., Bailey M.J., Howe B.D., Murray L., and Singh V.
- Abstract
Background: Septic shock is associated with decreased vasopressor responsiveness. Experimental data suggest that central alpha2-agonists like dexmedetomidine (DEX) increase vasopressor responsiveness and reduce catecholamine requirements in septic shock. However, DEX may also cause hypotension and bradycardia. Thus, it remains unclear whether DEX is hemodynamically safe or helpful in this setting. Method(s): In this post hoc subgroup analysis of the Sedation Practice in Intensive Care Evaluation (SPICE III) trial, an international randomized trial comparing early sedation with dexmedetomidine to usual care in critically patients receiving mechanical ventilation, we studied patients with septic shock admitted to two tertiary ICUs in Australia and Switzerland. The primary outcome was vasopressor requirements in the first 48 h after randomization, expressed as noradrenaline equivalent dose (NEq [mug/kg/min] = noradrenaline + adrenaline + vasopressin/0.4). Result(s): Between November 2013 and February 2018, 417 patients were recruited into the SPICE III trial at both sites. Eighty-three patients with septic shock were included in this subgroup analysis. Of these, 44 (53%) received DEX and 39 (47%) usual care. Vasopressor requirements in the first 48 h were similar between the two groups. Median NEq dose was 0.03 [0.01, 0.07] mug/kg/min in the DEX group and 0.04 [0.01, 0.16] mug/kg/min in the usual care group (p = 0.17). However, patients in the DEX group had a lower NEq/MAP ratio, indicating lower vasopressor requirements to maintain the target MAP. Moreover, on adjusted multivariable analysis, higher dexmedetomidine dose was associated with a lower NEq/MAP ratio. Conclusion(s): In critically ill patients with septic shock, patients in the DEX group received similar vasopressor doses in the first 48 h compared to the usual care group. On multivariable adjusted analysis, dexmedetomidine appeared to be associated with lower vasopressor requirements to maintain the target
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- 2020
31. The effect of dexmedetomidine on postoperative behaviour change in children: a randomised controlled trial
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Lee-Archer, P. F., von Ungern-Sternberg, B. S., Reade, M., Betts, M., Haenke, D., Keys, A., Rance, T., Gibbons, K., Long, D., Lee-Archer, P. F., von Ungern-Sternberg, B. S., Reade, M., Betts, M., Haenke, D., Keys, A., Rance, T., Gibbons, K., and Long, D.
- Abstract
Children may develop changes in their behaviour following general anaesthesia. Some examples of negative behaviour include temper tantrums and nightmares, as well as sleep and eating disorders. The aim of this study was to determine whether dexmedetomidine reduces the incidence of negative behaviour change after anaesthesia for day case surgery in children aged two to seven years. Children were randomly allocated to one of three groups: a premedication group received 2 mg.kg-1 intranasal dexmedetomidine; an intra-operative group received 1 mg.kg-1 intravenous dexmedetomidine; and a control group. The primary outcome was the incidence of negative behaviour on postoperative day 3 using the Post-Hospitalisation Behaviour Questionnaire for Ambulatory Surgery (PHBQ-AS) and the Strength and Difficulties Questionnaire (SDQ). Secondary outcomes included: the incidence of negative behaviour on postoperative days 14 and 28; anxiety at induction; emergence delirium; pain; length of recovery and hospital stay; and any adverse events. The data for 247 patients were analysed. Negative behaviour change on postoperative day 3 was similar between all three groups when measured with the PHBQ-AS (47%, 44% and 51% respectively; adjusted p=0.99) and the SDQ (median scores 7.5, 6.0 and 8.0 respectively; adjusted p=0.99). The incidence of negative behaviour in the group who received dexmedetomidine intra-operatively was less at postoperative day 28 (15% compared with 36% in the dexmedetomidine premedication group and 41% in the control group, p<0.001). We conclude that dexmedetomidine does not reduce the incidence of negative behaviour on postoperative day 3 in two to seven-year olds having day case procedures.
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- 2020
32. The effect of dexmedetomidine on postoperative behaviour change in children: a randomised controlled trial
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Lee-Archer, PF, von Ungern-Sternberg, BS, Reade, M, Betts, M, Haenke, D, Keys, A, Rance, T, Gibbons, K, Long, D, Lee-Archer, PF, von Ungern-Sternberg, BS, Reade, M, Betts, M, Haenke, D, Keys, A, Rance, T, Gibbons, K, and Long, D
- Abstract
Children may develop changes in their behaviour following general anaesthesia. Some examples of negative behaviour include temper tantrums and nightmares, as well as sleep and eating disorders. The aim of this study was to determine whether dexmedetomidine reduces the incidence of negative behaviour change after anaesthesia for day case surgery in children aged two to seven years. Children were randomly allocated to one of three groups: a premedication group received 2 mg.kg-1 intranasal dexmedetomidine; an intra-operative group received 1 mg.kg-1 intravenous dexmedetomidine; and a control group. The primary outcome was the incidence of negative behaviour on postoperative day 3 using the Post-Hospitalisation Behaviour Questionnaire for Ambulatory Surgery (PHBQ-AS) and the Strength and Difficulties Questionnaire (SDQ). Secondary outcomes included: the incidence of negative behaviour on postoperative days 14 and 28; anxiety at induction; emergence delirium; pain; length of recovery and hospital stay; and any adverse events. The data for 247 patients were analysed. Negative behaviour change on postoperative day 3 was similar between all three groups when measured with the PHBQ-AS (47%, 44% and 51% respectively; adjusted p=0.99) and the SDQ (median scores 7.5, 6.0 and 8.0 respectively; adjusted p=0.99). The incidence of negative behaviour in the group who received dexmedetomidine intra-operatively was less at postoperative day 28 (15% compared with 36% in the dexmedetomidine premedication group and 41% in the control group, p<0.001). We conclude that dexmedetomidine does not reduce the incidence of negative behaviour on postoperative day 3 in two to seven-year olds having day case procedures.
- Published
- 2020
33. The JET high frequency pellet injector project
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Geraud, Alain, Dentan, M., Whitehead, A., Butcher, P., Communal, D., Faisse, F., Gedney, J., Gros, G., Guillaume, D., Hackett, L., Hennion, V., Homfray, D., Lucock, R., McKivitt, J., Sibbald, M., Portafaix, C., Perin, J.P., Reade, M., Sands, D., Saille, A., Symonds, I., M.Watson, Worth, L., and Vinyar, I.
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- 2007
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34. Blood pressure monitoring in aeromedical care
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Reade, M. C. and Corkeron, M. A.
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- 2013
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35. RE. Autologous Fresh Whole Blood Transfusion Training -- a Narrative Review and Report of U.S. Military Experience.
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Chan, D. L. and Reade, M. C.
- Subjects
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EDUCATION of military personnel , *NEEDLESTICK injuries , *AUTOTRANSFUSION of blood , *MEDICAL errors , *BLOODBORNE infections , *BLOOD transfusion reaction , *SIMULATION methods in education , *MILITARY service , *DISEASE risk factors - Published
- 2024
36. Experiences of medical practitioners in the Australian Defence Force on live tissue trauma training
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Mahoney, Adam, primary, Reade, M C, additional, and Moffat, M, additional
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- 2020
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37. The effect of dexmedetomidine on postoperative behaviour change in children: a randomised controlled trial
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Lee‐Archer, P. F., primary, von Ungern‐Sternberg, B. S., additional, Reade, M., additional, Betts, M., additional, Haenke, D., additional, Keys, A., additional, Rance, T., additional, Gibbons, K., additional, and Long, D., additional
- Published
- 2020
- Full Text
- View/download PDF
38. Over view of major traumatic injury in Australia––Implications for trauma system design
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Cameron, P.A., primary, Fitzgerald, M.C., additional, Curtis, K., additional, McKie, E., additional, Gabbe, B., additional, Earnest, A., additional, Christey, G., additional, Clarke, C., additional, Crozier, J., additional, Dinh, M., additional, Ellis, D.Y., additional, Howard, T., additional, Joseph, A.P., additional, McDermott, K., additional, Matthew, J., additional, Ogilvie, R., additional, Pollard, C., additional, Rao, S., additional, Reade, M., additional, Rushworth, N., additional, and Zalstein, S., additional
- Published
- 2020
- Full Text
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39. Temporary epicardial pacing after cardiac surgery: a practical review: Part 2: Selection of epicardial pacing modes and troubleshooting
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Reade, M. C.
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- 2007
40. Temporary epicardial pacing after cardiac surgery: a practical review: Part 1: General considerations in the management of epicardial pacing
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Reade, M. C.
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- 2007
41. Nitric oxide synthase is downregulated, while haem oxygenase is increased, in patients with septic shock
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Reade, M. C., Millo, J. L., Young, J. D., and Boyd, C. A. R.
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- 2005
42. Early Results From the ‘Diggers to Veterans’ Longitudinal Study of Australian Men who Served in the First World War Short-and Long-Term Mortality of Early Enlisters
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McCalman, J, Kippen, R, McMeeken, J, Hopper, J, Reade, M, McCalman, J, Kippen, R, McMeeken, J, Hopper, J, and Reade, M
- Abstract
As the world marks the centenaries of the First World War, we still know remarkably little about the life course effects of military service. This paper reports on the first iteration of a cradle-to-grave dataset of men who enlisted and served overseas in the First World War from the state of Victoria, Australia. It examines mortality during military service and in civilian life and finds that mortality in both cases was strongly correlated with individual characteristics. Tall men and young single men were more likely to die in the war. In civilian life, mortality followed closely the pattern for Australian men, and was again highly correlated with individual characteristics and social class.
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- 2019
43. The Australian Trauma Registry
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Fitzgerald, MC, Curtis, K, Cameron, PA, Ford, JE, Howard, TS, Crozier, JA, Fitzgerald, A, Gruen, RL, Pollard, C, Martin, B, Clarke, C, Read, D, Christey, G, McDermott, K, Reade, M, Rushworth, N, Judson, R, Zalstein, S, Vallmuur, K, Rao, S, Joseph, T, Mathew, J, Dinh, M, Civil, I, Gabbe, B, Harrison, J, Morgan, M, McLellan, S, Isles, S, Mckie, E, Fitzgerald, MC, Curtis, K, Cameron, PA, Ford, JE, Howard, TS, Crozier, JA, Fitzgerald, A, Gruen, RL, Pollard, C, Martin, B, Clarke, C, Read, D, Christey, G, McDermott, K, Reade, M, Rushworth, N, Judson, R, Zalstein, S, Vallmuur, K, Rao, S, Joseph, T, Mathew, J, Dinh, M, Civil, I, Gabbe, B, Harrison, J, Morgan, M, McLellan, S, Isles, S, and Mckie, E
- Abstract
INTRODUCTION: Injuries are a major cause of disability and lost productivity. The case for a national trauma registry has been recognized by the Australian Commission on Safety and Quality in Health Care and at a policy level. BACKGROUND: The need was flagged in 1993 by the Royal Australasian College of Surgeons and the Australasian Trauma Society. In 2003, the Centre of National Research and Disability funded the Australian and New Zealand National Trauma Registry Consortium, which produced three consecutive annual reports. The bi-national trauma minimum dataset was also developed during this time. Operations were suspended thereafter. METHOD: In response to sustained lobbying the Australian Trauma Quality Improvement Program including the Australian Trauma Registry (ATR) commenced in 2012, with data collection from 26 major trauma centres. An inaugural report was released in late 2014. RESULT: The Federal Government provided funding in December 2016 enabling the work of the ATR to continue. Data are currently being collected for cases that meet inclusion criteria with dates of injury in the 2017-2018 financial year. Since implementation, the number of submitted records has been increased from fewer than 7000 per year to over 8000 as completeness has improved. Four reports have been released and are available to stakeholders. CONCLUSION: The commitment shown by the College, other organizations and individuals to the vision of a national trauma registry has been consistent since 1993. The ATR is now well placed to improve the care of injured people.
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- 2019
44. l-Arginine Transport across the Basal Plasma Membrane of the Syncytiotrophoblast of the Human Placenta from Normal and Preeclamptic Pregnancies
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Speake, P F., Glazier, J D., Ayuk, P T.-Y., Reade, M, Sibley, C P., and D’Souza, S W.
- Published
- 2003
45. Of mice and men (and rats): implications of species and stimulus differences for the interpretation of studies of nitric oxide in sepsis
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Reade, M. C. and Young, J. D.
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- 2003
46. Resuscitating academic anaesthesia – or trying to breathe life into a dead corpse?
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Reade, M.
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- 2002
47. On the Minimum of Re[f(z)/z] for Univalent Functions
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Reade, M. O., primary and Silverman, H., additional
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- 1991
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48. Sedation intensity in the first 48 hours of mechanical ventilation and 180-day mortality: A multinational prospective longitudinal cohort study.
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Weisbrodt L., Shehabi Y., Chamberlain J., Bicknell A., Roberts B., Casey E., Cheng A., Inskip D., Myburgh J., Holmes J., Santamaria J., Smith R., Nair P., Reynolds C., Johnson B., Sterba M., Wong K.K., Venugopal S., Rai V., Shahnaz M., Ramoo V., Jose S., Ozturk O., Ramlee S.N.Z., Foon B.S., Amran R., Narula R.K.A., Md Ramly E.S., Hapiz K.A., I-Liang L., Morad M.H.C., Ali M.N., Raihan H.N., Azizum S.I., Suzana Y., Haryati H., Zawati S.S., Ismeev J.N., Zulkarnain M.A., Omar M., Omar S.A., Ismail S.R., Hassan N., Zakaria Z., Mohtar S., Ahmad M., Suai W., Ai Li W., Lan J.S., Rohayah S.S., Mahadir F., Lian T.S., Zain M.M., Ahmad N., Mahazir K., Bakar A.A., Nan H.W., Tan Ai Ping S., Ngan S.C.L., Har L.C., Hassan J., Brown J., Gilders E., Parke R., McArthur C., Newby L., Simmonds C., Henderson S., Mehrtens J., Browne T., Cubis D., Goodson J., Nelson S., MacKle D., Pecher S., Ti L., Lim D., Wong Y., Ho B., Chia N., Yi N., Kalyanasundaram G., Webb S., Bellomo R., Kadiman S., Ti L.K., Howe B., Reade M.C., Khoo T.M., Alias A., Wong Y.-L., Mukhopadhyay A., Webb S.A., Green M., Bailey M.J., Ibrom E., Maher C., Mashonganyika C., McKee H., Bennett V., Cooper D.J., Vallance S., Eastwood G., Peck L., Reade M., Young H., Eliott S., Mercer I., Sidhu J., Whitfield A., Ding G., Hatfield P., Smith K., Coles T., Dennett J., Summers T., Ruther A., Anderson R., Jones E., Milliss D., Wong H., Botha J., Allsop S., Kanhere M., Wood J., Hogan C., Tai J., Williams T., Buckley A., Garrett P., McDonald S., Cuzner C., Seppelt I., Bass F., Edhouse P., Sana M., Weisbrodt L., Shehabi Y., Chamberlain J., Bicknell A., Roberts B., Casey E., Cheng A., Inskip D., Myburgh J., Holmes J., Santamaria J., Smith R., Nair P., Reynolds C., Johnson B., Sterba M., Wong K.K., Venugopal S., Rai V., Shahnaz M., Ramoo V., Jose S., Ozturk O., Ramlee S.N.Z., Foon B.S., Amran R., Narula R.K.A., Md Ramly E.S., Hapiz K.A., I-Liang L., Morad M.H.C., Ali M.N., Raihan H.N., Azizum S.I., Suzana Y., Haryati H., Zawati S.S., Ismeev J.N., Zulkarnain M.A., Omar M., Omar S.A., Ismail S.R., Hassan N., Zakaria Z., Mohtar S., Ahmad M., Suai W., Ai Li W., Lan J.S., Rohayah S.S., Mahadir F., Lian T.S., Zain M.M., Ahmad N., Mahazir K., Bakar A.A., Nan H.W., Tan Ai Ping S., Ngan S.C.L., Har L.C., Hassan J., Brown J., Gilders E., Parke R., McArthur C., Newby L., Simmonds C., Henderson S., Mehrtens J., Browne T., Cubis D., Goodson J., Nelson S., MacKle D., Pecher S., Ti L., Lim D., Wong Y., Ho B., Chia N., Yi N., Kalyanasundaram G., Webb S., Bellomo R., Kadiman S., Ti L.K., Howe B., Reade M.C., Khoo T.M., Alias A., Wong Y.-L., Mukhopadhyay A., Webb S.A., Green M., Bailey M.J., Ibrom E., Maher C., Mashonganyika C., McKee H., Bennett V., Cooper D.J., Vallance S., Eastwood G., Peck L., Reade M., Young H., Eliott S., Mercer I., Sidhu J., Whitfield A., Ding G., Hatfield P., Smith K., Coles T., Dennett J., Summers T., Ruther A., Anderson R., Jones E., Milliss D., Wong H., Botha J., Allsop S., Kanhere M., Wood J., Hogan C., Tai J., Williams T., Buckley A., Garrett P., McDonald S., Cuzner C., Seppelt I., Bass F., Edhouse P., and Sana M.
- Abstract
Objectives: In the absence of a universal definition of light or deep sedation, the level of sedation that conveys favorable outcomes is unknown. We quantified the relationship between escalating intensity of sedation in the first 48 hours of mechanical ventilation and 180-day survival, time to extubation, and delirium. Design(s): Harmonized data from prospective multicenter international longitudinal cohort studies Setting: Diverse mix of ICUs. Patient(s): Critically ill patients expected to be ventilated for longer than 24 hours. Intervention(s): Richmond Agitation Sedation Scale and pain were assessed every 4 hours. Delirium and mobilization were assessed daily using the Confusion Assessment Method of ICU and a standardized mobility assessment, respectively. Measurements and Main Results: Sedation intensity was assessed using a Sedation Index, calculated as the sum of negative Richmond Agitation Sedation Scale measurements divided by the total number of assessments. We used multivariable Cox proportional hazard models to adjust for relevant covariates. We performed subgroup and sensitivity analysis accounting for immortal time bias using the same variables within 120 and 168 hours. The main outcome was 180-day survival. We assessed 703 patients in 42 ICUs with a mean (sd) Acute Physiology and Chronic Health Evaluation II score of 22.2 (8.5) with 180-day mortality of 32.3% (227). The median (interquartile range) ventilation time was 4.54 days (2.47-8.43 d). Delirium occurred in 273 (38.8%) of patients. Sedation intensity, in an escalating dose-dependent relationship, independently predicted increased risk of death (hazard ratio [95% CI], 1.29 [1.15-1.46]; p < 0.001, delirium hazard ratio [95% CI], 1.25 [1.10-1.43]), p value equals to 0.001 and reduced chance of early extubation hazard ratio (95% CI) 0.80 (0.73-0.87), p value of less than 0.001. Agitation level independently predicted subsequent delirium hazard ratio [95% CI], of 1.25 (1.04-1.49), p value equals to
- Published
- 2018
49. Strategies to Reduce Inappropriate Laboratory Blood Test Orders in Intensive Care Are Effective and Safe: A Before-And-After Quality Improvement Study
- Author
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Dhanani, J. A., Barnett, A. G., Lipman, J., Reade, M. C., Dhanani, J. A., Barnett, A. G., Lipman, J., and Reade, M. C.
- Abstract
Unnecessary pathology tests performed in intensive care units (ICU) might lead to increased costs of care and potential patient harm due to unnecessary phlebotomy. We hypothesised that a multimodal intervention program could result in a safe and effective reduction in the pathology tests ordered in our ICU. We conducted a single-centre pre- and post-study using multimodal interventions to address commonly ordered routine tests. The study was performed during the same six month period (August to February) over three years: 2012 to 2013 (pre-intervention), 2013 to 2014 (intervention) and 2014 to 2015 (post-intervention). Interventions consisted of staff education, designing new pathology forms, consultant-led pathology test ordering and intensive monitoring for a six-month period. The results of the study showed that there was a net savings of over A$213,000 in the intervention period and A$175,000 in the post-intervention period compared to the pre-intervention period. There was a 28% reduction in the tests performed in the intervention period (P <0.0001 compared to pre-intervention period) and 26% in the post-intervention period (P <0.0001 compared to pre-intervention period). There were no ICU or hospital mortality differences between the groups. There were no significant haemoglobin differences between the groups. A multimodal intervention safely reduced pathology test ordering in the ICU, resulting in substantial cost savings.
- Published
- 2018
50. Early repeat computed tomographic imaging in transferred trauma and neurosurgical patients: Incidence, indications and impact
- Author
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Blazak, P, Hacking, C, Presneill, J, Reade, M, Blazak, P, Hacking, C, Presneill, J, and Reade, M
- Abstract
INTRODUCTION: Computed tomographic (CT) imaging is widely available in Australian rural and remote hospitals and is often performed prior to patient transfer to definitive tertiary hospital care. We hypothesised that critically ill trauma and neurosurgical patients might have CT scans repeated after interhospital transfer and that the utility of this practice might be low in relation to the additional financial cost and radiation exposure. METHODS: We conducted a retrospective review of clinical records to determine the proportion of trauma and neurosurgical patients transferred to our tertiary ICU from other hospitals between 1 June 2013 and 30 June 2014 who underwent a repeat CT scan. The additional effective radiation dose was estimated using the dose length product method and the Australian Medicare Benefits Schedule was used to estimate the associated cost. RESULTS: Of the 247 patients transferred for trauma and neurosurgical indications, many (144; 58%) had undergone CT imaging at the referring hospital. Repeat scans were performed in 60 (42%) already imaged patients (24% of all transferred patients), most frequently for changed clinical indications. While in 11 (18%) of those 60 already imaged patients the repeat scan led to an identifiable change in management, for another 13 (22%) patients the repeat scans appeared to be potentially avoidable. The median cost of a repeat scan was AU$250 and the median additional effective radiation dose was 2.74 mSv per patient. CONCLUSION: Repeat CT scans for patients already imaged prior to transfer were relatively common, occurring mostly for apparently valid clinical reasons. However, the additional radiation risk and financial cost of these repeat scans appeared on retrospective audit to be potentially avoidable in approximately one in five cases.
- Published
- 2018
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