Search

Your search keyword '"Rea, Federico"' showing total 1,724 results
Start Over Author "Rea, Federico"
1,724 results on '"Rea, Federico"'

3. Long-term adherence to polytherapy in heart failure patients: a novel approach emphasising the importance of secondary prevention

Author

Fontana, Nicole, Savaré, Laura, Rea, Federico, Di Angelantonio, Emanuele, and Ieva, Francesca

Subjects
Statistics - Applications
Abstract

Heart failure (HF) is a severe and costly clinical syndrome associated with increased healthcare costs and a high burden of mortality and morbidity. Although drug therapy is the mainstay of treatment for heart failure, non-adherence to prescribed therapies is common and is associated with worse health outcomes and increased hospitalizations. In this study, we propose a novel approach using Latent Markov models to analyze drug adherence to polytherapy over time using a secondary database. Our methodology enables us to evaluate patients' drug utilization behaviour, identify complex behavioural patterns, and incorporate them into predictive models to improve clinical outcomes. The significance of adhering to prescribed therapies for patients' prognosis has been highlighted in this study. Our findings show that adherent patients gained an additional ten months of life over a seven-year follow-up period compared to non-adherent patients. This underscores the importance of secondary prevention and continuous monitoring of heart failure patients. These procedures are crucial for identifying areas of improvement and promoting better adherence to prescribed therapies., Comment: 15 pages; 5 figures; 4 tables

Published
2023

5. Gram-negative bacterial colonizations before bilateral lung transplant. The impact of ‘targeted’ versus ‘standard’ surgical prophylaxis

Author

Congedi, Sabrina, Peralta, Arianna, Muraro, Luisa, Biscaro, Martina, Pettenuzzo, Tommaso, Sella, Nicolò, Crociani, Silvia, Tagne, Arméla Anne-Sabine, Caregnato, Ida, Monteleone, Francesco, Rossi, Elisa, Roca, Gabriella, Manfrin, Silvia, Marinello, Serena, Mazzitelli, Maria, Dell’Amore, Andrea, Cattelan, Annamaria, Rea, Federico, Navalesi, Paolo, and Boscolo, Annalisa

Published
2024
Full Text
View/download PDF

10. A Multicenter Retrospective Case-Control Study on Simple vs Extended Sleeve Lobectomies

Author

Campisi, Alessio, Dell’Amore, Andrea, Faccioli, Eleonora, Fang, Wentao, Chen, Tangbin, Ji, Chunyu, Gabryel, Piotr, Sielewicz, Magdalena, Piwkowski, Cezary, Park, Samina, Kim, Young Tae, Bongiolatti, Stefano, Mugnaini, Giovanni, Voltolini, Luca, Catelli, Chiara, Giovannetti, Riccardo, Infante, Maurizio, Bertolaccini, Luca, Spaggiari, Lorenzo, Ehrsam, Jonas, Schöb, Othmar, Inci, Ilhan, and Rea, Federico

Published
2024
Full Text
View/download PDF

15. Survival Outcome After Surgery in Patients With Thymoma Distant Recurrence

Author

Chiappetta, Marco, Sassorossi, Carolina, Nachira, Dania, Lococo, Filippo, Meacci, Elisa, Ruffini, Enrico, Guerrera, Francesco, Lyberis, Paraskevas, Aprile, Vittorio, Lucchi, Marco, Ambrogi, Marcello Carlo, Bacchin, Diana, Dell’Amore, Andrea, Marino, Carlotta, Comacchio, Giovannimaria, Roca, Gabriella, Rea, Federico, and Margaritora, Stefano

Published
2024
Full Text
View/download PDF

21. Assessing the role of phosphorylated S6 ribosomal protein in the pathological diagnosis of pulmonary antibody-mediated rejection

Author

Lunardi, Francesca, Vedovelli, Luca, Pezzuto, Federica, Le Pavec, Jerome, Dorfmuller, Peter, Ivanovic, Marina, Pena, Tahuanty, Wassilew, Katharina, Perch, Michael, Hirschi, Sandrine, Chenard, Marie-Pierre, Sosa, Rebecca A., Goddard, Martin, Neil, Desley, Montero-Fernandez, Angeles, Rice, Alexandra, Cozzi, Emanuele, Rea, Federico, Levine, Deborah J., Roux, Antoine, Fishbein, Gregory A., and Calabrese, Fiorella

Published
2024
Full Text
View/download PDF

22. Sex Differences in Outcomes of Intravenous Thrombolysis in Acute Ischemic Stroke Patients with Preadmission Use of Antiplatelets

Author

Noseda, Roberta, Rea, Federico, Pagnamenta, Alberto, Agazzi, Pamela, Bianco, Giovanni, Sihabdeen, Shairin, Seiffge, David, Michel, Patrik, Nedeltchev, Krassen, Bonati, Leo, Kägi, Georg, Niederhauser, Julien, Nyffeler, Thomas, Luft, Andreas, Wegener, Susanne, Schelosky, Ludwig, Medlin, Friedrich, Rodic, Biljana, Peters, Nils, Renaud, Susanne, Mono, Marie-Luise, Carrera, Emmanuel, Fischer, Urs, Ceschi, Alessandro, and Cereda, Carlo Walter

Published
2023
Full Text
View/download PDF

30. A multicentric evaluation of pediatric lung transplantation in Italy

Author

Schiavon, Marco, Camagni, Stefania, Venuta, Federico, Rosso, Lorenzo, Boffini, Massimo, Parisi, Francesco, Bertani, Alessandro, Meloni, Federica, Paladini, Piero, Faccioli, Eleonora, Colledan, Michele, Diso, Daniele, Cattaneo, Margherita, Scalini, Fabrizio, Alfieri, Sara, Giunta, Domenica, Morosini, Monica, Luzzi, Luca, Lorenzoni, Giulia, Dell'Amore, Andrea, and Rea, Federico

Published
2023
Full Text
View/download PDF

36. Multidrug-Resistant and Extended-Spectrum β-Lactamase Gram-Negative Bacteria in Bilateral Lung Transplant Recipients: Incidence, Risk Factors, and In-Hospital Mortality

Author

Boscolo, Annalisa, Sella, Nicolò, Pettenuzzo, Tommaso, De Cassai, Alessandro, Crociani, Silvia, Schiavolin, Chiara, Simoni, Caterina, Geraldini, Federico, Lorenzoni, Giulia, Faccioli, Eleonora, Fortarezza, Francesco, Lunardi, Francesca, Giraudo, Chiara, Dell’Amore, Andrea, Cattelan, Annamaria, Calabrese, Fiorella, Gregori, Dario, Rea, Federico, and Navalesi, Paolo

Published
2022
Full Text
View/download PDF

43. Protective action of natural and induced immunization against the occurrence of delta or alpha variants of SARS-CoV-2 infection: a test-negative case-control study

Author

Corrao, Giovanni, Franchi, Matteo, Rea, Federico, Cereda, Danilo, Barone, Antonio, Borriello, Catia Rosanna, Della Valle, Petra Giulia, Ercolanoni, Michele, Fortino, Ida, Jara, Jose, Leoni, Olivia, Mazziotta, Francesco, Pierini, Elisabetta, Preziosi, Giuseppe, Tirani, Marcello, Galli, Massimo, Bertolaso, Guido, Pavesi, Giovanni, and Bortolan, Francesco

Published
2022
Full Text
View/download PDF

47. Cost‐effectiveness of outpatient adherence to recommendations for monitoring of patients hospitalized for heart failure.

Author

Corrao, Giovanni, Rea, Federico, Iommi, Marica, Lallo, Adele, Fantaci, Giovanna, Di Martino, Mirko, Davoli, Marina, Leoni, Olivia, Pompili, Marco, Scondotto, Salvatore, De Luca, Giovanni, Carle, Flavia, Lorusso, Stefano, Giordani, Cristina, Di Lenarda, Andrea, and Maggioni, Aldo Pietro

Subjects
SURVIVAL rate, HEART failure patients, MEDICAL care costs, MINERALOCORTICOID receptors, OUTPATIENT medical care
Abstract

Aims: A set of indicators to assess the quality of care for patients hospitalized for heart failure was developed by an expert working group of the Italian Health Ministry. Because a better performance profile measured using these indicators does not necessarily translate to better outcomes, a study to validate these indicators through their relationship with measurable clinical outcomes and healthcare costs supported by the Italian National Health System was carried out. Methods and results: Residents of four Italian regions (Lombardy, Marche, Lazio, and Sicily) who were newly hospitalized for heart failure (irrespective of stage and New York Heart Association class) during 2014–2015 entered in the cohort and followed up until 2019. Adherence to evidence‐based recommendations [i.e. renin–angiotensin–aldosterone system (RAS) inhibitors, beta‐blockers, mineralocorticoid receptor antagonists (MRAs), and echocardiograms (ECCs)] experienced during the first year after index discharge was assessed. Composite clinical outcomes (cardiovascular hospital admissions and all‐cause mortality) and healthcare costs (hospitalizations, drugs, and outpatient services) were assessed during the follow‐up. The restricted mean survival time at 5 years (denoted as the number of months free from clinical outcomes), the hazard of clinical outcomes (according to the Cox model), and average annual healthcare cost (expressed in euros per person‐year) were compared between adherent and non‐adherent patients. A non‐parametric bootstrap method based on 1000 resamples was used to account for uncertainty in cost‐effectiveness estimates. A total of 41 406 patients were included in this study (46.3% males, mean age 76.9 ± 9.4 years). Adherence to RAS inhibitors, beta‐blockers, MRAs, and ECCs were 64%, 57%, 62%, and 20% among the cohort members, respectively. Compared with non‐adherent patients, those who adhered to ECCs, RAS inhibitors, beta‐blockers, and MRAs experienced (i) a delay in the composite outcome of 1.6, 1.9, 1.6, and 0.6 months and reduced risks of 9% (95% confidence interval, 2–14%), 11% (7–14%), 8% (5–11%), and 4% (−1–8%), respectively; and (ii) lower (€262, €92, and €571 per year for RAS inhibitors, beta‐blockers, and MRAs, respectively) and higher costs (€511 per year for ECC). Adherence to RAS inhibitors, beta‐blockers, and MRAs showed a delay in the composite outcome and a saving of costs in 98%, 84%, and 93% of the 1000 bootstrap replications, respectively. Conclusions: Strict monitoring of patients with heart failure through regular clinical examinations and drug therapies should be considered the cornerstone of national guidelines and audits. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

48. Time Trends in Liver-Related Mortality in People With and Without Diabetes: Results From a Population-Based Study.

Author

Ciardullo, Stefano, Morabito, Gabriella, Rea, Federico, Savaré, Laura, Perseghin, Gianluca, and Corrao, Giovanni

Subjects
PEOPLE with diabetes, MEDICAL care use, DEATH rate, CANCER-related mortality, LIVER diseases
Abstract

Context Patients with diabetes are at increased risk of dying from liver-related events, but little is known on whether this increased risk has changed in recent years. Objective The aim of the present study is to describe time trends in cause-specific liver-related mortality in people with and without diabetes from the general Italian population. Methods Data were retrieved from the health care utilization databases of Lombardy, a region of Italy that accounts for about 16% (almost 10 million) of its population. Annual cause-specific mortality rates and proportionate mortality were computed among individuals with and without diabetes from 2010 to 2019. Liver-related deaths were categorized as viral, alcohol related, and nonviral nonalcohol related (NVNA). Results Liver diseases were responsible for 2% and 1% of deaths in people with and without diabetes (2019). Among patients with diabetes, the crude mortality rate for liver diseases decreased from 1.13 to 0.64 deaths per 1000 person-years from 2010 to 2019. The largest proportion of liver-related deaths was attributable to NVNA diseases and it increased from 63% in 2010 to 68% in 2019, with a corresponding relative reduction of viral causes (from 27% to 23%). The standardized mortality ratio for patients with diabetes was 3.35 (95% CI 2.96-3.76) for NVNA, 1.66 (95% CI 1.33-2.01) for viral hepatitis, and 1.61 (95% CI 1.13-2.17) for alcoholic liver disease and it remained relatively stable over time. Excess mortality risk in patients with diabetes for liver-related mortality was higher than for cardiovascular mortality and cancer. Conclusion While liver-related mortality rates decreased significantly among patients with diabetes, NVNA causes made up the majority of cases. Excess mortality for liver-related causes in patients with diabetes compared with controls remained constant in the studied period. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

49. Comparative Analysis of Comprehensive Genomic Profile in Thymomas and Recurrent Thymomas Reveals Potentially Actionable Mutations for Target Therapies.

Author

Lococo, Filippo, De Paolis, Elisa, Evangelista, Jessica, Dell'Amore, Andrea, Giannarelli, Diana, Chiappetta, Marco, Campanella, Annalisa, Sassorossi, Carolina, Cancellieri, Alessandra, Calabrese, Fiorella, Conca, Alessandra, Vita, Emanuele, Minucci, Angelo, Bria, Emilio, Castello, Angelo, Urbani, Andrea, Rea, Federico, Margaritora, Stefano, and Scambia, Giovanni

Subjects
GENETIC profile, PROPENSITY score matching, GENOMICS, CELL cycle, INDIVIDUALIZED medicine
Abstract

Molecular profiles of thymomas and recurrent thymomas are far from being defined. Herein, we report an analysis of a comprehensive genetic profile (CGP) in a highly selected cohort of recurrent thymomas. Among a cohort of 426 thymomas, the tissue was available in 23 recurrent tumors for matching the biomolecular results obtained from primary and relapse samples. A control group composed of non-recurrent thymoma patients was selected through a propensity score match analysis. CGP was performed using the NGS Tru-SightOncology assay to evaluate TMB, MSI, and molecular alterations in 523 genes. CGP does not differ when comparing initial tumor with tumor relapse. A significantly higher frequency of cell cycle control genes alterations (100.0% vs. 57.1%, p = 0.022) is detected in patients with early recurrence (<32 months) compared to late recurrent cases. The CGPs were similar in recurrent thymomas and non-recurrent thymomas. Finally, based on NGS results, an off-label treatment or clinical trial could be potentially proposed in >50% of cases (oncogenic Tier-IIC variants). In conclusion, CGPs do not substantially differ between initial tumor vs. tumor recurrence and recurrent thymomas vs. non-recurrent thymomas. Cell cycle control gene alterations are associated with an early recurrence after thymectomy. Multiple target therapies are potentially available by performing a comprehensive CGP, suggesting that a precision medicine approach on these patients could be further explored. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

50. Is There a Link between Chronic Obstructive Pulmonary Disease and Lung Adenocarcinoma? A Clinico-Pathological and Molecular Study.

Author

Lunardi, Francesca, Nardo, Giorgia, Lazzarini, Elisabetta, Tzorakoleftheraki, Sofia-Eleni, Comacchio, Giovanni Maria, Fonzi, Eugenio, Tebaldi, Michela, Vedovelli, Luca, Pezzuto, Federica, Fortarezza, Francesco, Schiavon, Marco, Rea, Federico, Indraccolo, Stefano, and Calabrese, Fiorella

Subjects
NUCLEOTIDE sequencing, OBSTRUCTIVE lung diseases, CHRONIC obstructive pulmonary disease, RAS oncogenes, LUNG cancer
Abstract

Chronic Obstructive Pulmonary Disease (COPD) and lung cancer are strictly related. To date, it is unknown if COPD-associated cancers are different from the tumors of non-COPD patients. The main goal of the study was to compare the morphological/molecular profiles of lung adenocarcinoma (LUAD) samples of COPD, non-COPD/smokers and non-COPD/non-smokers, and to investigate if a genetic instability also characterized non-pathological areas. This study included 110 patients undergoing surgery for a LUAD, divided into three groups: COPD/smoker LUAD (38), non-COPD/smoker LUAD (54) and non-COPD/non-smoker LUAD (18). The tissue samples were systemically evaluated by pathologists and analyzed using a 30-gene Next Generation Sequencing (NGS) panel. In a subset of patients, tissues taken far from the neoplasia were also included. The non-COPD/smoker LUAD were characterized by a higher proliferative index (p = 0.001), while the non-COPD/non-smoker LUAD showed higher percentages of lepidic pattern (p = 0.008), lower necrosis, higher fibrosis, and a significantly lower mutation rate in the KRAS and PIK3CA genes. Interestingly, the same gene mutations were found in pathological and normal areas exclusively in the COPD/smokers and non-COPD/smokers. COPD/smoker LUAD seem to be similar to non-COPD/smoker LUAD, particularly for the genetic background. A less aggressive cancer phenotype was confirmed in non-COPD/non-smokers. The genetic alterations detected in normal lungs from smokers with and without COPD reinforce the importance of screening to detect early neoplastic lesions. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results